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EC Tree
The taxonomic range for the selected organisms is: Rattus norvegicus The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
mevalonate diphosphate decarboxylase, mevalonate pyrophosphate decarboxylase, diphosphomevalonate decarboxylase, mevalonate-5-pyrophosphate decarboxylase, mevalonate 5-diphosphate decarboxylase, pyrophosphomevalonate decarboxylase, scmdd, 5-pyrophosphomevalonate decarboxylase, scmdd1, scmdd2,
more
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Mevalonate pyrophosphate decarboxylase
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5-Pyrophosphomevalonate decarboxylase
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Decarboxylase, pyrophosphomevalonate
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Mevalonate (diphospho)decarboxylase
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mevalonate 5'-diphosphate decarboxylase
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Mevalonate 5-diphosphate decarboxylase
Mevalonate pyrophosphate decarboxylase
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Mevalonate-5-pyrophosphate decarboxylase
Pyrophosphomevalonate decarboxylase
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Pyrophosphomevalonic acid decarboxylase
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Mevalonate 5-diphosphate decarboxylase
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Mevalonate 5-diphosphate decarboxylase
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Mevalonate-5-pyrophosphate decarboxylase
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Mevalonate-5-pyrophosphate decarboxylase
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ATP:(R)-5-diphosphomevalonate carboxy-lyase (adding ATP; isopentenyl-diphosphate-forming)
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ATP + 5-diphosphomevalonate
ADP + phosphate + isopentenyl diphosphate + CO2
additional information
?
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ATP + 5-diphosphomevalonate
ADP + phosphate + isopentenyl diphosphate + CO2
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-
?
ATP + 5-diphosphomevalonate
ADP + phosphate + isopentenyl diphosphate + CO2
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-
-
?
ATP + 5-diphosphomevalonate
ADP + phosphate + isopentenyl diphosphate + CO2
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?
ATP + 5-diphosphomevalonate
ADP + phosphate + isopentenyl diphosphate + CO2
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?
ATP + 5-diphosphomevalonate
ADP + phosphate + isopentenyl diphosphate + CO2
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?
ATP + 5-diphosphomevalonate
ADP + phosphate + isopentenyl diphosphate + CO2
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?
ATP + 5-diphosphomevalonate
ADP + phosphate + isopentenyl diphosphate + CO2
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enzyme activity is increased by 5fold after feeding young rats 2.5% cholestyramine for ten days to four weeks
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?
additional information
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major enzyme involved in cholesterol biosynthesis in rat liver
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?
additional information
?
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the enzyme is involved in cholesterol biosynthesis
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?
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ATP + 5-diphosphomevalonate
ADP + phosphate + isopentenyl diphosphate + CO2
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enzyme activity is increased by 5fold after feeding young rats 2.5% cholestyramine for ten days to four weeks
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?
additional information
?
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additional information
?
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major enzyme involved in cholesterol biosynthesis in rat liver
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?
additional information
?
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the enzyme is involved in cholesterol biosynthesis
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?
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Mg2+
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divalent metal ion required, Mg2+, Mn2+ or Co2+
Co2+
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divalent metal ion required, Mg2+, Mn2+ or Co2+
Co2+
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Mn2+ and Co2+ are the best activators for the 45000 MW enzyme form
Mn2+
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divalent metal ion required, Mg2+, Mn2+ or Co2+
Mn2+
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Mn2+ is the best activator for the 37000 MW enzyme form
Mn2+
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Mn2+ and Co2+ are the best activators for the 45000 MW enzyme form
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(2E)-3,7-dimethylocta-2,6-dien-1-yl 2-(4-hydroxy-4-methyl-6-oxotetrahydro-2H-pyran-2-yl)ethyl diphosphate
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(2E)-3,7-dimethylocta-2,6-dien-1-yl 4-(4-hydroxy-4-methyl-6-oxotetrahydro-2H-pyran-2-yl)butyl diphosphate
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1-(diphosphenyloxy)-3,4-dimethylpentan-3-ol
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1-(diphosphenyloxy)-3-methylpentan-3-ol
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1-(diphosphenyloxy)-5-fluoro-3-methylpentan-3-ol
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2,2-difluoromevalonate 5-diphosphate
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2-fluoromevalonate 5-diphosphate
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irreversible inhibitor
24S-hydroxycholesterol
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down-regulates the expression
3-ethyl-2-fluoro-3,5-dihydroxy-pentanate 5-diphosphate
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4-(diphosphenyloxy)-2-methylbutan-2-ol
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4-(diphosphenyloxy)-2-phenylbutan-2-ol
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P'-geranyl 2-fluoromevalonate 5-diphosphate
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irreversible inhibitor
P'-geranyl 3,5,8-trihydroxy-3-methyloctanate 8-diphosphate
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additional information
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probucol decreases mevalonate pyrophosphate decarboxylase in the rat liver
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0.02 - 0.92
5-diphosphomevalonate
0.02
5-diphosphomevalonate
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0.02
5-diphosphomevalonate
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37000 MW enzyme form
0.0227
5-diphosphomevalonate
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45000 MW enzyme form
0.036
5-diphosphomevalonate
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0.036
5-diphosphomevalonate
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wild type enzyme
0.71
5-diphosphomevalonate
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45000 MW enzyme form
0.75
5-diphosphomevalonate
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mutant enzyme K27A
0.92
5-diphosphomevalonate
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mutant enzyme R154A
0.00053
ATP
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0.53
ATP
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wild type enzyme
0.8
ATP
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37000 MW enzyme form
1.4
ATP
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mutant enzyme R154A
1.87
ATP
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mutant enzyme K27A
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0.00302
2-fluoromevalonate 5-diphosphate
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in 100 mM Tris buffer, pH 7.5, at 25°C
0.0046
P'-geranyl 2-fluoromevalonate 5-diphosphate
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in 100 mM Tris buffer, pH 7.5, at 25°C
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0.0026
(2E)-3,7-dimethylocta-2,6-dien-1-yl 2-(4-hydroxy-4-methyl-6-oxotetrahydro-2H-pyran-2-yl)ethyl diphosphate
Rattus norvegicus
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0.0065
(2E)-3,7-dimethylocta-2,6-dien-1-yl 4-(4-hydroxy-4-methyl-6-oxotetrahydro-2H-pyran-2-yl)butyl diphosphate
Rattus norvegicus
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0.12
1-(diphosphenyloxy)-3,4-dimethylpentan-3-ol
Rattus norvegicus
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0.08
1-(diphosphenyloxy)-3-methylpentan-3-ol
Rattus norvegicus
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0.05
1-(diphosphenyloxy)-5-fluoro-3-methylpentan-3-ol
Rattus norvegicus
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0.0075
2,2-difluoromevalonate 5-diphosphate
Rattus norvegicus
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0.02
3-ethyl-2-fluoro-3,5-dihydroxy-pentanate 5-diphosphate
Rattus norvegicus
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0.06
4-(diphosphenyloxy)-2-methylbutan-2-ol
Rattus norvegicus
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0.14
4-(diphosphenyloxy)-2-phenylbutan-2-ol
Rattus norvegicus
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0.002
P'-geranyl 3,5,8-trihydroxy-3-methyloctanate 8-diphosphate
Rattus norvegicus
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additional information
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additional information
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7
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37000 MW form and 45000 MW form
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4 - 9
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about 35% of maximal activity at pH 4 and at pH 9, 37000 MW enzyme form
6 - 9
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pH 6: about 35% of maximal activity, pH 9: about 30% of maximal activity, 45000 MW enzyme form
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UniProt
brenda
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brenda
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brenda
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brenda
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brenda
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brenda
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brenda
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brenda
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brenda
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low activity
brenda
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brenda
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low activity
brenda
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brenda
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brenda
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brenda
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brenda
highest expression in liver
brenda
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low activity
brenda
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in female rat the activity is lower than in male rat
brenda
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brenda
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in female rats the activity is higher than in male animals
brenda
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decrease in activity when rats are fasted, fed with a diet containing 2% cholesterol or made diabetic, increase in activity when the animals are fed with a diet containing 3% cholestyramine
brenda
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lower activity of mevalonate-diphosphate decarboxylase is responsible for the reduced cholesterol biosynthesis in the liver of stroke-prone spontaneously hypertensive rat
brenda
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from animals fed a diet containing cholestyramine and pravastin
brenda
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predominantly located in
brenda
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37000 Da and 45000 Da enzyme species
brenda
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brenda
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contains a small amount of the 45000 Da enzyme species, but not the 37000 Da species. The 45000 Da enzyme species is localized in the matrix
brenda
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MVD1_RAT
401
0
43893
Swiss-Prot
other Location (Reliability: 2 )
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37000
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2 * 37000, enzyme form is induced by the diet containing cholestyramine and pravastin, SDS-PAGE
45000
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2 * 45000, SDS-PAGE
45000
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x * 45000, SDS-PAGE
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additional information
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a diet containing 5% cholestyramine and 0.1% pravastatin induces a new enzyme species of 37000 Da
dimer
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2 * 45000, SDS-PAGE
dimer
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2 * 37000, enzyme form is induced by the diet containing cholestyramine and pravastin, SDS-PAGE
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additional information
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intracellular glycosylation does not contribute to the difference between the 45000 MW form and the 37000 MW form of the enzyme
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stabilized by phenylmethylsulfonyl fluoride, aprotinin and leupeptin
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-20°C or -73°C, rat liver homogenate with 0.1 mM leupeptin, 0.75 mg/l aprotinin, 0.1 mM phenylmethylsulfonyl fluoride, 15 mM EDTA, 15 mM EGTA, stable for over 3 months
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2 enzyme forms: MW 37000 and MW 45000. The MW 37000 enzyme form is induced by the diet containing cholestyramine and pravastin
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nickel metal affinity column chromatography
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expressed in Escherichia coli BL21(DE3) cells
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MPD mRNA expression in liver and MPD protein in brain of stroke-prone spontaneously hypertensive rats is significantly reduced
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medicine
the upregulation of microRNA-214 and downregulation of mevalonate diphosphate decarboxylase transcription in the liver both play a role in the development of hypocholesterolemia in stroke-prone spontaneously hypertensive rats
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Jabalquinto, A.M.; Cardemil, E.
The effect of diabetes, nutritional factors, and sex on rat liver and kidney mevalonate kinase, mevalonate-5-phosphate kinase, and mevalonate-5-pyrophosphate decarboxylase
Arch. Biochem. Biophys.
210
132-139
1981
Rattus norvegicus
brenda
Toth, M.J.; Huwyler, L.; Park, J.
Purification of rat liver mevalonate pyrophosphate decarboxylase
Prep. Biochem. Biotechnol.
26
47-51
1996
Rattus norvegicus
brenda
Michihara, A.; Sawamura, M.; Nara, Y.; Ikeda, K.; Yamori, Y.
Purification and characterization of two mevalonate pyrophosphate decarboxylases from rat liver: a novel molecular species of 37 kDa
J. Biochem.
122
647-654
1997
Rattus norvegicus
brenda
Hulcher, F.H.
Modification of the radiochemical assay of rat liver mevalonate-5-diphosphate decarboxylase and induction and stabilization of the activity
Biochem. Biophys. Res. Commun.
181
1449-1455
1991
Rattus norvegicus
brenda
Sawamura, M.; Nara, Y.; Yamori, Y.
Liver mevalonate 5-pyrophosphate decarboxylase is responsible for reduced serum cholesterol in stroke-prone spontaneously hypertensive rat
J. Biol. Chem.
267
6051-6055
1992
Rattus norvegicus
brenda
Michihara, A.; Akasaki, K.; Yamori, Y.; Tsuji, H.
Tissue distribution of a major mevalonate pyrophosphate decarboxylase in rats
Biol. Pharm. Bull.
24
1231-1234
2001
Rattus norvegicus
brenda
Michihara, A.; Sawamura, M.; Yamori, Y.; Akasaki, K.; Tsuji, H.
Mevalonate pyrophosphate decarboxylase is predominantly located in the cytosol of rat hepatocytes
Biol. Pharm. Bull.
24
1235-1240
2001
Rattus norvegicus
brenda
Michihara, A.; Sawamura, M.; Yamori, Y.; Akasaki, K.; Tsuji, H.
Difference in subcellular distribution between 45- and 37-kDa mevalonate pyrophosphate decarboxylase in rat liver
Biol. Pharm. Bull.
24
1347-1350
2001
Rattus norvegicus
brenda
Michihara, A.; Sawamura, M.; Yamori, Y.; Akasaki, K.; Tsuji, H.
Probucol decreases mevalonate pyrophosphate decarboxylase in the rat liver
Biol. Pharm. Bull.
26
1484-1486
2003
Rattus norvegicus
brenda
Qiu, Y.; Li, D.
Bifunctional inhibitors of mevalonate kinase and mevalonate 5-diphosphate decarboxylase
Org. Lett.
8
1013-1016
2006
Rattus norvegicus
brenda
Qiu, Y.; Li, D.
Inhibition of mevalonate 5-diphosphate decarboxylase by fluorinated substrate analogs
Biochim. Biophys. Acta
1760
1080-1087
2006
Rattus norvegicus
brenda
Qiu, Y.; Gao, J.; Guo, F.; Qiao, Y.; Li, D.
Mutation and inhibition studies of mevalonate 5-diphosphate decarboxylase
Bioorg. Med. Chem. Lett.
17
6164-6168
2007
Rattus norvegicus
brenda
Wang, Y.; Muneton, S.; Sjoevall, J.; Jovanovic, J.N.; Griffiths, W.J.
The effect of 24S-hydroxycholesterol on cholesterol homeostasis in neurons: quantitative changes to the cortical neuron proteome
J. Proteome Res.
7
1606-1614
2008
Rattus norvegicus
brenda
Michihara, A.; Shimatani, M.; Akasaki, K.
Comparison of the gene expression levels of mevalonate pyrophosphate decarboxylase between stroke-prone spontaneously hypertensive and Wistar Kyoto rats
J. Health Sci.
56
733-737
2010
Rattus norvegicus (Q62967)
-
brenda
Michihara, A.; Ide, N.; Mizutani, Y.; Okamoto, M.; Uchida, M.; Matsuoka, H.; Akasaki, K.
Involvement of microRNA214 and transcriptional regulation in reductions in mevalonate pyrophosphate decarboxylase mRNA levels in stroke-prone spontaneously hypertensive rat livers
Biosci. Biotechnol. Biochem.
79
1759-1770
2015
Rattus norvegicus (Q62967)
brenda