Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

Disease on EC 4.1.1.31 - phosphoenolpyruvate carboxylase

Please use the Disease Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Acidosis
Acid Loading Unmasks Glucose Homeostatic Instability in Proximal-Tubule-Targeted Insulin/Insulin-Like-Growth-Factor-1 Receptor Dual Knockout Mice.
cAMP-dependent stabilization of phosphoenolpyruvate carboxykinase mRNA in LLC-PK1-F+ kidney cells.
Changes in mRNAs for enzymes of glutamine metabolism in kidney and liver during ammonium chloride acidosis.
Changes in renal metabolite profile and ammoniagenesis during acute and chronic metabolic acidosis in dog and rat.
Concurrent binding and modifications of AUF1 and HuR mediate the pH-responsive stabilization of phosphoenolpyruvate carboxykinase mRNA in kidney cells.
Development of ammonia and glucose productions from glutamine in foetal rat kidney; effects of metabolic acidosis.
Differential expression and acid-base regulation of glutaminase mRNAs in gluconeogenic LLC-PK(1)-FBPase(+) cells.
Distribution along the rat nephron of three enzymes of gluconeogenesis in acidosis and starvation.
Effect of acidosis on phosphoenolpyruvate carboxykinase and glutaminase mRNAs in rat kidney and in LLC-PK-F+ cells.
Effect of acute alterations in acid-base balance on rat renal glutaminase and phosphoenolpyruvate carboxykinase gene expression.
Effect of collecting duct-specific deletion of both Rh B Glycoprotein (Rhbg) and Rh C Glycoprotein (Rhcg) on renal response to metabolic acidosis.
Effect of stress on hepatic 11beta-hydroxysteroid dehydrogenase activity and its influence on carbohydrate metabolism.
Effects of metabolic acidosis and diabetes on the abundance of specific renal mRNAs.
Hepatic 11 beta-hydroxysteroid dehydrogenase 1 involvement in alterations of glucose metabolism produced by acidotic stress in rat.
Hormonal and acid-base regulation of phosphoenolpyruvate carboxykinase mRNA levels in rat kidney.
Induction of Phosphoenolpyruvate Carboxykinase (PEPCK) during Acute Acidosis and Its Role in Acid Secretion by V-ATPase-Expressing Ionocytes.
Induction of renal phosphoenolpyruvate carboxykinase mRNA: suppressive effect of glucose.
Influence of phosphoenolpyruvate carboxykinase inhibition on the response of NH3 production to acute acidosis.
Inhibition of glutamine synthetase in the mouse kidney: a novel mechanism of adaptation to metabolic acidosis.
Involvement of glucocorticoids in the stimulation of rat kidney phosphoenolpyruvate carboxykinase activity after liver intoxication by carbon tetrachloride.
Localization and hormonal control of serine dehydratase during metabolic acidosis differ markedly from those of phosphoenolpyruvate carboxykinase in rat kidney.
Mechanism of altered renal glutaminase gene expression in response to chronic acidosis.
Mechanism of increased renal gene expression during metabolic acidosis.
Messenger RNA for renal phosphoenolpyruvate carboxykinase (GTP). Its translation in a heterologous cell-free system and its regulation by glucocorticoids and by changes in acid-base balance.
Metabolism of [2-13C]succinate in renal cells determined by 13C NMR.
p38 MAPK mediates acid-induced transcription of PEPCK in LLC-PK(1)-FBPase(+) cells.
PEPCK mRNA localization in proximal tubule and gene regulation during metabolic acidosis.
pH-responsive, gluconeogenic renal epithelial LLC-PK1-FBPase+cells: a versatile in vitro model to study renal proximal tubule metabolism and function.
Phosphoenolpyruvate carboxykinase in urine exosomes reflect impairment in renal gluconeogenesis in early insulin resistance and diabetes.
Pre-ejection period of cardiac cycles in fetal lamb.
Promoter elements that mediate the pH response of PCK mRNA in LLC-PK1-F+ cells.
Proteomic profiling and pathway analysis of the response of rat renal proximal convoluted tubules to metabolic acidosis.
Regulation of phosphoenolpyruvate carboxykinase (GTP) synthesis in the kidney.
Regulation of phosphoenolpyruvate carboxykinase mRNA in mouse liver, kidney, and fat tissues by fasting, diabetes, and insulin.
Regulation of renal amino acid transporters during metabolic acidosis.
Renal enzymes during experimental diabetes mellitus in the rat. Role of insulin, carbohydrate metabolism, and ketoacidosis.
Renal phosphoenolpyruvate carboxykinase during perturbations of acid-base homeostasis in rats. Immunochemical studies.
Role of AUF1 and HuR in the pH-responsive stabilization of phosphoenolpyruvate carboxykinase mRNA in LLC-PK1-F+ cells.
RT-PCR localization of phosphoenolpyruvate carboxykinase in the proximal tubule of the rat during metabolic acidosis.
Significance of the intracellular distribution of phosphoenolpyruvate carboxykinase in acidosis.
The effect of steroids and ammonium chloride acidosis on phosphoenolpyruvate carboxykinase in rat kidney cortex. I. Differentiation of the inductive process and characterization of enzyme activities.
The effect of steroids and ammonium chloride acidosis on phosphoenolpyruvate carboxykinase in rat kidney cortex. II. The kinetics of enzyme induction.
The kidney of chicken adapts to chronic metabolic acidosis: in vivo and in vitro studies.
[Stimulation of gluconeogenic capacity in partially hepatectomized rats (author's transl)]
Acidosis, Lactic
Cytosolic Phosphoenolpyruvate Carboxykinase Deficiency: Cause of Hypoglycemia-Induced Seizure and Death.
Lactic acidosis and renal phosphoenolpyruvate carboxykinase activity during exercise.
Novel missense variants in PCK1 gene cause cytosolic PEPCK deficiency with growth failure from inadequate caloric intake.
Overcoming diabetes-induced hyperglycemia through inhibition of hepatic phosphoenolpyruvate carboxykinase (GTP) with RNAi.
Adenoma
Diethylnitrosamine induces long-lasting re-expression of insulin-like growth factor II during early stages of liver carcinogenesis in mice.
Adenoviridae Infections
Adenovirus E1A represses the cyclic AMP-induced transcription of the gene for phosphoenolpyruvate carboxykinase (GTP) in hepatoma cells.
Bacterial Infections
Integrated Metabolomics, Transcriptomics and Proteomics Identifies Metabolic Pathways Affected by Anaplasma phagocytophilum Infection in Tick Cells.
Brain Ischemia
Hyperglycemia is associated with enhanced gluconeogenesis in a rat model of permanent cerebral ischemia.
Breast Cyst
Quantification of pepsinogen C and prostaglandin D synthase in breast cyst fluid and their potential utility for cyst type classification.
Breast Neoplasms
Deleted in breast cancer 1 (DBC1) protein regulates hepatic gluconeogenesis.
Expression of androgen receptor and two androgen-induced proteins (apolipoprotein D and pepsinogen C) in ductal carcinoma in situ of the breast.
Immunoenzymatically determined pepsinogen C concentration in breast tumor cytosols: an independent favorable prognostic factor in node-positive patients.
Quantification of pepsinogen C and prostaglandin D synthase in breast cyst fluid and their potential utility for cyst type classification.
Screening of core genes and pathways in breast cancer development via comprehensive analysis of multi gene expression datasets.
Candidiasis
Candida albicans RHO1 is required for cell viability in vitro and in vivo.
Carcinoma
Association of phosphoenolpyruvate carboxykinase 1 protein kinase activity-dependent sterol regulatory element-binding protein 1 activation with prognosis of oesophageal carcinoma.
Expression of androgen receptor and two androgen-induced proteins (apolipoprotein D and pepsinogen C) in ductal carcinoma in situ of the breast.
Carcinoma, Hepatocellular
3-Aminobenzamide inhibits poly(ADP ribose) synthetase activity and induces phosphoenolpyruvate carboxykinase (GTP) in H4IIE hepatoma cells.
5-aminoimidazole-4-carboxamide riboside mimics the effects of insulin on the expression of the 2 key gluconeogenic genes PEPCK and glucose-6-phosphatase.
5alpha-reduced glucocorticoids, novel endogenous activators of the glucocorticoid receptor.
A novel role of bone morphogenetic protein 6 (BMP6) in glucose homeostasis.
A point mutation of the AF2 transactivation domain of the glucocorticoid receptor disrupts its interaction with steroid receptor coactivator 1.
A selective system for hepatoma cells producing gluconeogenic enzymes.
Activation of the ras mitogen-activated protein kinase-ribosomal protein kinase pathway is not required for the repression of phosphoenolpyruvate carboxykinase gene transcription by insulin.
Activities of key gluconeogenic enzymes and glycogen synthase in rat and human livers, hepatomas, and hepatoma cell cultures.
Acute and chronic regulation of phosphoenolpyruvate carboxykinase mRNA by insulin and glucose.
Adenovirus E1A proteins regulate phosphoenolpyruvate carboxykinase gene transcription through multiple mechanisms.
Adenovirus E1A represses the cyclic AMP-induced transcription of the gene for phosphoenolpyruvate carboxykinase (GTP) in hepatoma cells.
Adiponectin represses gluconeogenesis independent of insulin in hepatocytes.
An extract of Syzygium aromaticum represses genes encoding hepatic gluconeogenic enzymes.
Bioactive polyphenols in kinkéliba tea (Combretum micranthum) and their glucose-lowering activities.
C/EBP? is AMP kinase sensitive and up-regulates PEPCK in response to ER stress in hepatoma cells.
CCAAT/enhancer-binding protein alpha mediates induction of hepatic phosphoenolpyruvate carboxykinase by p38 mitogen-activated protein kinase.
Characterization of a complex glucocorticoid response unit in the phosphoenolpyruvate carboxykinase gene.
Characterization of the binding sites for [3H]glibenclamide in rat liver membranes.
Comparison of the effects of insulin and okadaic acid on phosphoenolpyruvate carboxykinase gene expression.
Culture at high density increases phosphoenolpyruvate carboxykinase messenger RNA in H4IIEC3 hepatoma cells.
Cyclic AMP stabilizes the mRNA for phosphoenolpyruvate carboxykinase (GTP) against degradation.
Different transcription factor binding arrays modulate the cAMP responsivity of the phosphoenolpyruvate carboxykinase gene promoter.
Differential activity of a tissue-specific extinguisher locus in hepatic and nonhepatic cells.
Differential regulation of endogenous glucose-6-phosphatase and phosphoenolpyruvate carboxykinase gene expression by the forkhead transcription factor FKHR in H4IIE-hepatoma cells.
Dual specificity MAPK phosphatase 3 activates PEPCK gene transcription and increases gluconeogenesis in rat hepatoma cells.
Effects of 6- and 8-substituted analogs of adenosine 3':5'-monophosphate on phosphoenolpyruvate carboxykinase and tyrosine aminotransferase in hepatoma cell cultures.
Effects of amino acid analogues on protein synthesis and degradation in isolated cells.
Effects of catechin-rich green tea on gene expression of gluconeogenic enzymes in rat hepatoma H4IIE cells.
Effects of cyclic adenosine monophosphate, dexamethasone and insulin on phosphoenolpyruvate carboxykinase synthesis in Reuber H-35 hepatoma cells.
Effects of nipradilol, a nitric oxide-releasing beta-adrenoceptor blocking agent, on phosphoenolpyruvate carboxykinase gene transcription in a rat hepatoma cell line.
Efficient delivery of siRNA using dendritic poly(L-lysine) for loss-of-function analysis.
Endoplasmic reticulum stress-induced activation of activating transcription factor 6 decreases cAMP-stimulated hepatic gluconeogenesis via inhibition of CREB.
Enhancement of phenotypic expression in cultured malignant liver epithelial cells by a complex medium.
Evidence for selective induction of phosphoenolpyruvate carboxykinase gene expression by unsaturated and nonmetabolized fatty acids in adipocytes.
Expression of the phosphoenolpyruvate carboxykinase gene and its insulin regulation during differentiation of preadipose cell lines.
Extinction of phosphoenolpyruvate carboxykinase gene expression is associated with loss of a specific chromatin-binding protein from a far upstream domain.
Genetic activity of a trans-regulatory locus in hepatoma hybrid cells.
Gentiopicroside and sweroside from Veratrilla baillonii Franch. induce phosphorylation of Akt and suppress Pck1 expression in hepatoma cells.
Gi alpha 2 mediates the inhibitory regulation of adenylylcyclase in vivo: analysis in transgenic mice with Gi alpha 2 suppressed by inducible antisense RNA.
Glucocorticoids use a positive liver element to repress fibrate-induced adipose transcription of the phosphoenolpyruvate carboxykinase gene.
Glucokinase expression in rat hepatoma cells induces glucose uptake and is rate limiting in glucose utilization.
Gluconeogenic enzyme PCK1 deficiency promotes CHK2 O-GlcNAcylation and hepatocellular carcinoma growth upon glucose deprivation.
Hepatic gluconeogenic key enzymes in patients with hepatic cancer.
Hepatic nuclear factor 3- and hormone-regulated expression of the phosphoenolpyruvate carboxykinase and insulin-like growth factor-binding protein 1 genes.
Hormonal control of interacting promoters introduced into cells by retroviruses.
Hormonal regulation of chimeric genes containing the phosphoenolpyruvate carboxykinase promoter regulatory region in hepatoma cells infected by murine retroviruses.
Hormonal regulation of phosphoenolpyruvate carboxykinase gene expression is mediated through modulation of an already disrupted chromatin structure.
Hormonal regulation of the phosphoenolpyruvate carboxykinase gene. Role of specific CCAAT/enhancer-binding protein isoforms.
Human evidence for the involvement of insulin-induced gene 1 in the regulation of plasma glucose concentration.
Hypoglycemic effects of brassinosteroid in diet-induced obese mice.
Identification of tumor necrosis factor as a transcriptional regulator of the phosphoenolpyruvate carboxykinase gene following endotoxin treatment of mice.
Image-aided Suicide Gene Therapy Utilizing Multifunctional hTERT-targeting Adenovirus for Clinical Translation in Hepatocellular Carcinoma.
Impaired suppression of gluconeogenesis induced by overexpression of a noninsulin-responsive phosphoenolpyruvate carboxykinase gene.
Inhibition by insulin of protein kinase A-induced transcription of the phosphoenolpyruvate carboxykinase gene. Mediation by the activation domain of cAMP response element-binding protein (CREB) and factors bound to the TATA box.
Inhibitors of signalling identify differential control processes responsible for selective effects of insulin on the expression of phosphoenolpyruvate carboxykinase and gene 33 in rat H4 hepatoma cells.
Insulin decreases H4IIE cell PEPCK mRNA by a mechanism that does not involve cAMP.
Insulin decreases phosphoenolpyruvate carboxykinase (GTP) mRNA activity by a receptor-mediated process.
Insulin production by engineered muscle cells.
Insulin pulses less effective than continuous insulin in inhibiting PEPCK mRNA levels stimulated by cAMP and dexamethasone in perifused hepatoma cells.
Insulin represses phosphoenolpyruvate carboxykinase gene transcription by causing the rapid disruption of an active transcription complex: a potential epigenetic effect.
Insulin-like effects of inositol phosphate-glycan on messenger RNA expression in rat hepatocytes.
Interaction of a liver-specific factor with an enhancer 4.8 kilobases upstream of the phosphoenolpyruvate carboxykinase gene.
Interaction of trans-acting factors and re-expression of liver functions in hepatoma hybrid cells.
Knockdown of the Sonic Hedgehog (SHH) Gene Inhibits Proliferation of Hep3B and SMMC-7721 Hepatocellular Carcinoma Cells via the PI3K/Akt/PCK1 Signaling Pathway.
Lead (Pb) exposure promotes diabetes in obese rodents.
Lithium inhibits hepatic gluconeogenesis and phosphoenolpyruvate carboxykinase gene expression.
Liver x receptors regulate the transcriptional activity of the glucocorticoid receptor: implications for the carbohydrate metabolism.
Location and characterization of two widely separated glucocorticoid response elements in the phosphoenolpyruvate carboxykinase gene.
Loss of TR4 orphan nuclear receptor reduces phosphoenolpyruvate carboxykinase-mediated gluconeogenesis.
Melatonin stimulates transcription of the rat phosphoenolpyruvate carboxykinase gene in hepatic cells.
Modulation of phosphoenolpyruvate carboxykinase mRNA levels by the hepatocellular hydration state.
Molecular basis for effects of carcinogenic heavy metals on inducible gene expression.
Multihormonal regulation of phosphoenolpyruvate carboxykinase-chloramphenicol acetyltransferase fusion genes. Insulin's effects oppose those of cAMP and dexamethasone.
Multiple elements regulate phosphoenolpyruvate carboxykinase gene expression in hepatoma hybrid cells.
Nur77 suppresses hepatocellular carcinoma via switching glucose metabolism toward gluconeogenesis through attenuating phosphoenolpyruvate carboxykinase sumoylation.
Oxidative and chemical stress mimic insulin by selectively inhibiting the expression of phosphoenolpyruvate carboxykinase in hepatoma cells.
Oxidative Stress Induces Phosphoenolpyruvate Carboxykinase Expression in H4IIE Cells.
PCK1 negatively regulates cell cycle progression and hepatoma cell proliferation via the AMPK/p27Kip1 axis.
Phenolic Diterpenes from Rosemary Suppress cAMP Responsiveness of Gluconeogenic Gene Promoters.
Phosphoenolpyruvate carboxykinase is induced in growth-arrested hepatoma cells.
Phosphorylation of CREB affects its binding to high and low affinity sites: implications for cAMP induced gene transcription.
Polyphenolic compounds from Artemisia dracunculus L. inhibit PEPCK gene expression and gluconeogenesis in an H4IIE hepatoma cell line.
Properties of phosphoenolpyruvate carboxykinase (guanosine triphosphate) synthesized in hepatoma cells in the presence of amino acid analogues.
Protein synthesis and insulin regulation of p33 and PEPCK gene expression.
Proteomic Analysis of Hepatocellular Carcinoma Tissues With Encapsulation Shows Up-regulation of Leucine Aminopeptidase 3 and Phosphoenolpyruvate Carboxykinase 2.
Purification and characterization of insulin-mimetic inositol phosphoglycan-like molecules from grass pea (Lathyrus sativus) seeds.
Reciprocal regulation of gene transcription by insulin. Inhibition of the phosphoenolpyruvate carboxykinase gene and stimulation of gene 33 in a single cell type.
Regulation of carbohydrate metabolism by the farnesoid X receptor.
Regulation of chimeric phosphoenolpyruvate carboxykinase genes by the trans-dominant locus TSE1.
Regulation of gene expression in rat hepatocytes and hepatoma cells by insulin: quantitation of messenger ribonucleic acid's coding for tyrosine aminotransferase, tryptophan oxygenase, and phosphoenolpyruvate carboxykinase.
Regulation of phosphoenolpyruvate carboxykinase and tyrosine transaminase in hepatoma cell cultures. 3. Comparative studies in H35, HTC, MH1C1 and RLC cells.
Regulation of phosphoenolpyruvate carboxykinase and tyrosine transaminase in hepatoma cell cultures. I. Effects of glucocorticoids, N 6 ,O 2' -dibutyryl cyclic adenosine 3',5'-monophosphate and insulin in Reuber H35 cells.
Regulation of phosphoenolpyruvate carboxykinase gene transcription by insulin and cAMP: reciprocal actions on initiation and elongation.
Regulation of phosphoenolpyruvate carboxykinase gene transcription in H4IIE hepatoma cells: evidence for a primary role of the catalytic subunit of 3',5'-cyclic adenosine monophosphate-dependent protein kinase.
Relative roles of CCAAT/enhancer-binding protein beta and cAMP regulatory element-binding protein in controlling transcription of the gene for phosphoenolpyruvate carboxykinase (GTP).
Repression and activation of transcription of phosphoenolpyruvate carboxykinase gene during liver development.
Repression of phosphoenolpyruvate carboxykinase gene activity by insulin is blocked by 3-aminobenzamide but not by PD128763, a selective inhibitor of poly(ADP-ribose) polymerase.
Response of the phosphoenolpyruvate carboxykinase gene to glucocorticoids depends on the integrity of the cAMP pathway.
Separate cis-regulatory elements confer expression of phosphoenolpyruvate carboxykinase (GTP) gene in different cell lines.
Specificity of a retinoic acid response element in the phosphoenolpyruvate carboxykinase gene promoter: consequences of both retinoic acid and thyroid hormone receptor binding.
Stimulation of phosphoenolpyruvate carboxykinase gene expression by fatty acids.
Structural constraints and importance of caffeic acid moiety for anti-hyperglycemic effects of caffeoylquinic acids from chicory.
Suppression of phosphoenolpyruvate carboxykinase gene expression by reduced endogenous glutathione level.
The 5'region of the rat phosphoenolpyruvate carboxykinase gene confers pH sensitivity to chimeric genes expressed in renal and liver cell lines capable of expressing PEPCK.
The alpha-isoform of the CCAAT/enhancer-binding protein is required for mediating cAMP responsiveness of the phosphoenolpyruvate carboxykinase promoter in hepatoma cells.
The gluconeogenic enzyme PCK1 phosphorylates INSIG1/2 for lipogenesis.
The inhibition of phosphoenolpyruvate carboxykinase (guanosine triphosphate) gene expression by insulin is not mediated by protein kinase C.
The inhibitory effect of tolbutamide on phosphoenolpyruvate carboxykinase activity in rat hepatoma H4IIE cells.
The liver-enriched transcription factor D-site-binding protein activates the promoter of the phosphoenolpyruvate carboxykinase gene in hepatoma cells.
The molecular physiology of hepatic nuclear factor 3 in the regulation of gluconeogenesis.
The oncoprotein HBXIP suppresses gluconeogenesis through modulating PCK1 to enhance the growth of hepatoma cells.
The oxazolidinedione CP-92,768-2 partially protects insulin receptor substrate-1 from dexamethasone down-regulation in 3T3-L1 adipocytes.
The regulation of glucose-6-phosphatase and phosphoenolpyruvate carboxykinase by autophagy in low-glycolytic hepatocellular carcinoma cells.
The repression of hormone-activated PEPCK gene expression by glucose is insulin-independent but requires glucose metabolism.
The role of protein synthesis in the decay of phosphoenolpyruvate carboxykinase messenger RNA.
The synergistic effect of dexamethasone and all-trans-retinoic acid on hepatic phosphoenolpyruvate carboxykinase gene expression involves the coactivator p300.
The use of Reuber hepatoma cells for the study of a lipopolysaccharide-induced macrophage factor: glucocorticoid-antagonizing factor.
Transcriptomic changes associated with PCK1 overexpression in hepatocellular carcinoma cells detected by RNA-seq.
Two Alkaloids from Bulbs of Lycoris sanguinea MAXIM. Suppress PEPCK Expression by Inhibiting the Phosphorylation of CREB.
Unmetabolized fenofibrate, but not fenofibric acid, activates AMPK and inhibits the expression of phosphoenolpyruvate carboxykinase in hepatocytes.
Vanadate inhibits expression of the gene for phosphoenolpyruvate carboxykinase (GTP) in rat hepatoma cells.
Vanadate normalizes hyperglycemia and phosphoenolpyruvate carboxykinase mRNA levels in ob/ob mice.
[Effect of insulin, cAMP, and dexamethasone on phosphoenolpyruvate carboxykinase gene promoter in vitro]
Carcinoma, Intraductal, Noninfiltrating
Expression of androgen receptor and two androgen-induced proteins (apolipoprotein D and pepsinogen C) in ductal carcinoma in situ of the breast.
Carcinoma, Non-Small-Cell Lung
Distribution and prognostic significance of gluconeogenesis and glycolysis in lung cancer.
PCK2 activation mediates an adaptive response to glucose depletion in lung cancer.
Chagas Disease
Phosphoenolpyruvate carboxykinase from T. cruzi magnetic beads affinity-based screening assays on crude plant extracts from Brazilian Cerrado.
Cholera
Anisoosmotic regulation of hepatic gene expression.
Cholestasis
Evaluation of key gluconeogenic enzymes in experimental biliary obstruction.
Reduction in phosphoenolpyruvate carboxykinase in rat liver parenchymal cells following experimentally induced cholestasis.
Colonic Neoplasms
Expression of phosphoenolpyruvate carboxykinase linked to chemoradiation susceptibility of human colon cancer cells.
Glucose-dependent transcriptional regulation of the human sucrase-isomaltase (SI) gene.
Lactate promotes PGE2 synthesis and gluconeogenesis in monocytes to benefit the growth of inflammation-associated colorectal tumor.
Colorectal Neoplasms
Inhibition of phosphoenolpyruvate carboxykinase blocks lactate utilization and impairs tumor growth in colorectal cancer.
Confusion
New partial sequences of phosphoenolpyruvate carboxylase as molecular phylogenetic markers.
Cryptococcosis
Cryptococcus neoformans requires a functional glycolytic pathway for disease but not persistence in the host.
Cystic Fibrosis
Involvement of hepatocyte nuclear factor 3 in endoderm differentiation of embryonic stem cells.
Microarray analysis reveals the inhibition of intestinal expression of nutrient transporters in piglets infected with porcine epidemic diarrhea virus.
Phenotypic plasticity in gene expression and physiological response in red drum Sciaenops ocellatus exposed to a long-term freshwater environment.
Cysts
Effect of antihydatid drugs on carbohydrate metabolism of metacestode of echinococcus granulosus.
Effects of mebendazole, albendazole, and praziquantel on fumarate hydratase, pyruvate kinase, and phosphoenolpyruvate carboxykinase of Echinococcus granulosus cyst wall harbored in mice.
Quantification of pepsinogen C and prostaglandin D synthase in breast cyst fluid and their potential utility for cyst type classification.
Dehydration
Evolutionary physiology: the extent of C4 and CAM photosynthesis in the genera Anacampseros and Grahamia of the Portulacaceae.
Expression of genes involved in energy mobilization and osmoprotectant synthesis during thermal and dehydration stress in the Antarctic midge, Belgica antarctica.
Induction of Crassulacean Acid Metabolism in the Facultative Halophyte Mesembryanthemum crystallinum by Abscisic Acid.
Leaf anatomy and photosynthetic carbon metabolic characteristics in Phragmites communis in different soil water availability
Nucleotide sequence of the lantibiotic Pep5 biosynthetic gene cluster and functional analysis of PepP and PepC. Evidence for a role of PepC in thioether formation.
Phosphoenolpyruvate carboxylase from pennywort (Umbilicus rupestris). Changes in properties after exposure to water stress.
Regulation of Phosphoenolpyruvate Carboxylase and Crassulacean Acid Metabolism Induction in Mesembryanthemum crystallinum L. by Cytokinin : Modulation of Leaf Gene Expression by Roots?
Regulation of phosphoenolpyruvate carboxylase in Pinus halepensis needles submitted to ozone and water stress.
Salt stress leads to differential expression of two isogenes of phosphoenolpyruvate carboxylase during Crassulacean acid metabolism induction in the common ice plant.
Sucrose phosphate synthase activity and the co-ordination of carbon partitioning during sucrose and amino acid accumulation in desiccation-tolerant leaf material of the C4 resurrection plant Sporobolus stapfianus during dehydration.
The activities of PEP carboxylase and the C(4) acid decarboxylases are little changed by drought stress in three C(4) grasses of different subtypes.
[Activity of NADP-dependent glyceraldehyde-phosphate dehydrogenase and phosphoenolpyruvate carboxylase in wheat leaves under water stress]
[Effect of water stress on phosphoenolpyruvate carboxylase activity in Mesembryanthemum crystallinum (L.)].
Dengue
Molecular dynamics study of the membrane interaction of a membranotropic dengue virus C protein-derived peptide.
Diabetes Mellitus
A susceptibility locus for early-onset non-insulin dependent (type 2) diabetes mellitus maps to chromosome 20q, proximal to the phosphoenolpyruvate carboxykinase gene.
Amelioration of glucose homeostasis by glycyrrhizic acid through gluconeogenesis rate-limiting enzymes.
Association of the promoter polymorphism -232C/G of the phosphoenolpyruvate carboxykinase gene (PCK1) with Type 2 diabetes mellitus.
Dynamic Behavior of Rat Phosphoenolpyruvate Carboxykinase Inhibitors: New Mechanism for Enzyme Inhibition.
Establishment of a canine model of human type 2 diabetes mellitus by overexpressing phosphoenolypyruvate carboxykinase.
Fasting hyperglycemia is not associated with increased expression of PEPCK or G6Pc in patients with Type 2 Diabetes.
Generation of fibroblasts overexpressing liver-specific PEPCK in a miniature pig model of human type 2 diabetes mellitus.
Hepatic phosphoenolpyruvate carboxykinase expression after gastric bypass surgery in rats with type 2 diabetes mellitus.
Hybrid of 1-deoxynojirimycin and polysaccharide from mulberry leaves treat diabetes mellitus by activating PDX-1/insulin-1 signaling pathway and regulating the expression of glucokinase, phosphoenolpyruvate carboxykinase and glucose-6-phosphatase in alloxan-induced diabetic mice.
Kinetic and structural analysis of Escherichia coli phosphoenolpyruvate carboxykinase mutants.
New approach in the treatment of T2DM and metabolic syndrome (focus on a novel insulin sensitizer).
Novel hypoglycemic effects of Ganoderma lucidum water-extract in obese/diabetic (+db/+db) mice.
PEPCK1 Antisense Oligonucleotide Prevents Adiposity and Impairs Hepatic Glycogen Synthesis in High-Fat Male Fed Rats.
Promoter polymorphism in PCK1 (phosphoenolpyruvate carboxykinase gene) associated with type 2 diabetes mellitus.
Relationships of SLC2A4, RBP4, PCK1, and PI3K Gene Polymorphisms with Gestational Diabetes Mellitus in a Chinese Population.
Structural and functional analysis of the human phosphoenolpyruvate carboxykinase gene promoter.
The characteristics of hepatic Gs?-cAMP axis in HSHF diet-fed obese insulin resistance rats and genetic diabetic mice.
The GID ubiquitin ligase complex is a regulator of AMPK activity and organismal lifespan.
Diabetes Mellitus, Type 2
A multicomponent insulin response sequence mediates a strong repression of mouse glucose-6-phosphatase gene transcription by insulin.
A susceptibility locus for early-onset non-insulin dependent (type 2) diabetes mellitus maps to chromosome 20q, proximal to the phosphoenolpyruvate carboxykinase gene.
Acute and selective regulation of glyceroneogenesis and cytosolic phosphoenolpyruvate carboxykinase in adipose tissue by thiazolidinediones in type 2 diabetes.
Adipose overexpression of phosphoenolpyruvate carboxykinase leads to high susceptibility to diet-induced insulin resistance and obesity.
Amelioration of glucose homeostasis by glycyrrhizic acid through gluconeogenesis rate-limiting enzymes.
Association of the promoter polymorphism -232C/G of the phosphoenolpyruvate carboxykinase gene (PCK1) with Type 2 diabetes mellitus.
cDNA sequence and localization of polymorphic human cytosolic phosphoenolpyruvate carboxykinase gene (PCK1) to chromosome 20, band q13.31: PCK1 is not tightly linked to maturity-onset diabetes of the young.
Central Administration of Resveratrol Improves Diet-Induced Diabetes.
Dapagliflozin suppresses glucagon signaling in rodent models of diabetes.
Ergostatrien-3?-ol from Antrodia camphorata Inhibits Diabetes and Hyperlipidemia in High-Fat-Diet Treated Mice via Regulation of Hepatic Related Genes, Glucose Transporter 4, and AMP-Activated Protein Kinase Phosphorylation.
Establishment of a canine model of human type 2 diabetes mellitus by overexpressing phosphoenolypyruvate carboxykinase.
Examination of the phosphoenolpyruvate carboxykinase gene promoter in patients with noninsulin-dependent diabetes mellitus.
Expression of phosphoenolpyruvate carboxykinase gene in human adipose tissue: induction by rosiglitazone and genetic analyses of the adipocyte-specific region of the promoter in type 2 diabetes.
Fasting hyperglycemia is not associated with increased expression of PEPCK or G6Pc in patients with Type 2 Diabetes.
Generation of fibroblasts overexpressing liver-specific PEPCK in a miniature pig model of human type 2 diabetes mellitus.
Hepatic phosphoenolpyruvate carboxykinase expression after gastric bypass surgery in rats with type 2 diabetes mellitus.
Hypoglycemic effect of protopanaxadiol-type ginsenosides and compound K on Type 2 Diabetes mice induced by high-fat diet combining with streptozotocin via suppression of hepatic gluconeogenesis.
Identification of a novel variant in the phosphoenolpyruvate carboxykinase gene promoter in Japanese patients with type 2 diabetes.
Indication for genetic linkage of the phosphoenolpyruvate carboxykinase (PCK1) gene region on chromosome 20q to non-insulin-dependent diabetes mellitus.
Inhibition of GSK-3 selectively reduces glucose-6-phosphatase and phosphatase and phosphoenolypyruvate carboxykinase gene expression.
Kinetic characterization of recombinant human cytosolic phosphoenolpyruvate carboxykinase with and without a His(10)-tag.
Large-scale study of the -232C > G polymorphism of PCK1 in Type 2 diabetes.
Mixed Inhibition of cPEPCK by Genistein, Using an Extended Binding Site Located Adjacent to Its Catalytic Cleft.
Novel hypoglycemic effects of Ganoderma lucidum water-extract in obese/diabetic (+db/+db) mice.
PEPCK1 Antisense Oligonucleotide Prevents Adiposity and Impairs Hepatic Glycogen Synthesis in High-Fat Male Fed Rats.
Promoter polymorphism in PCK1 (phosphoenolpyruvate carboxykinase gene) associated with type 2 diabetes mellitus.
Regulation of glyceroneogenesis and phosphoenolpyruvate carboxykinase by fatty acids, retinoic acids and thiazolidinediones: potential relevance to type 2 diabetes.
Relationships of SLC2A4, RBP4, PCK1, and PI3K Gene Polymorphisms with Gestational Diabetes Mellitus in a Chinese Population.
Search for a third susceptibility gene for maturity-onset diabetes of the young. Studies with eleven candidate genes.
STAT3 targets the regulatory regions of gluconeogenic genes in vivo.
Structural and functional analysis of the human phosphoenolpyruvate carboxykinase gene promoter.
The characteristics of hepatic Gs?-cAMP axis in HSHF diet-fed obese insulin resistance rats and genetic diabetic mice.
The GID ubiquitin ligase complex is a regulator of AMPK activity and organismal lifespan.
The promoter polymorphism -232C/G of the PCK1 gene is associated with type 2 diabetes in a UK-resident South Asian population.
Transgenic mice overexpressing phosphoenolpyruvate carboxykinase develop non-insulin-dependent diabetes mellitus.
[Effects of Astragalus membranaceus and Potentilla discolor mixture on insulin resistance and its related mRNA expressions in KKAy mice with type 2 diabetes].
[The role of arecoline on hepatic insulin resistance in type 2 diabetes rats].
Dyslipidemias
Forced internal desynchrony induces cardiometabolic alterations in adult rats.
Endotoxemia
Altered transcriptional regulation of phosphoenolpyruvate carboxykinase in rats following endotoxin treatment.
Efficacy of anti-tumor necrosis factor polyclonal antibody on phosphoenolpyruvate carboxykinase expression in septic and endotoxemic rats.
Excessive NO production dose not account for the inhibition of hepatic gluconeogenesis in endotoxemia.
Failure of glucagon to induce hepatic phosphoenolpyruvate carboxykinase in endotoxic shock.
Identification of tumor necrosis factor as a transcriptional regulator of the phosphoenolpyruvate carboxykinase gene following endotoxin treatment of mice.
Regulation of the acid-labile subunit in sustained endotoxemia.
[The effect of endotoxemia on gluconeogenesis in livers and kidneys during acute hepatic failure.]
Fatty Liver
Adenovirus-mediated expression of SIK1 improves hepatic glucose and lipid metabolism in type 2 diabetes mellitus rats.
Dual SGLT1/SGLT2 Inhibitor Phlorizin Ameliorates Non-Alcoholic Fatty Liver Disease and Hepatic Glucose Production in Type 2 Diabetic Mice.
Increased expression and activity of the transcription factor FOXO1 in nonalcoholic steatohepatitis.
Overcoming diabetes-induced hyperglycemia through inhibition of hepatic phosphoenolpyruvate carboxykinase (GTP) with RNAi.
Regulation of messenger ribonucleic acid expression for gluconeogenic enzymes during glucagon infusions into lactating cows.
Transgenic mice overexpressing SREBP-1a under the control of the PEPCK promoter exhibit insulin resistance, but not diabetes.
Fatty Liver, Alcoholic
Effects of Acetaldehyde on Hepatocyte Glycerol Uptake and Cell Size: Implication of Aquaporin 9.
Fetal Growth Retardation
Phosphoenolpyruvate carboxykinase in experimental intrauterine growth retardation in rats.
The effect of dexamethasone and surgically induced intrauterine growth retardation on renal and hepatic levels of phosphoenolpyruvate carboxykinase in the rat.
[Effect of intrauterine growth retardation on gluconeogenic enzymes in rat liver].
Gastroenteritis
Cytosolic phosphoenolpyruvate carboxykinase deficiency presenting with acute liver failure following gastroenteritis.
Gastrointestinal Neoplasms
Tumor-associated metabolic alterations in patients with gastric and esophageal cancer.
Glucose Intolerance
18?-Glycyrrhetinic acid acts through hepatocyte nuclear factor 4 alpha to modulate lipid and carbohydrate metabolism.
A high-throughput assay for modulators of mitochondrial membrane potential identifies a novel compound with beneficial effects on db/db mice.
A primary defect in glucose production alone cannot induce glucose intolerance without defects in insulin secretion.
CILP-2 is a novel secreted protein and associated with insulin resistance.
Comparative Effects of the Renin-Angiotensin System Blockers on Nonalcoholic Fatty Liver Disease and Insulin Resistance in C57Bl/6 Mice.
Deficiency of PDK1 in liver results in glucose intolerance, impairment of insulin-regulated gene expression and liver failure.
Distinct C/EBPalpha motifs regulate lipogenic and gluconeogenic gene expression in vivo.
Glucocorticoid exposure in late gestation permanently programs rat hepatic phosphoenolpyruvate carboxykinase and glucocorticoid receptor expression and causes glucose intolerance in adult offspring.
Hypothalamic JNK1 and IKK? activation and impaired early postnatal glucose metabolism after maternal perinatal high-fat feeding.
Impaired glucose tolerance and increased weight gain in transgenic rats overexpressing a non-insulin-responsive phosphoenolpyruvate carboxykinase gene.
Intergenerational consequences of fetal programming by in utero exposure to glucocorticoids in rats.
Ketogenic diet-fed rats have increased fat mass and phosphoenolpyruvate carboxykinase activity.
Par14 protein associates with insulin receptor substrate 1 (IRS-1), thereby enhancing insulin-induced IRS-1 phosphorylation and metabolic actions.
Porcine adiponectin receptor 1 transgene resists high-fat/sucrose diet-induced weight gain, hepatosteatosis and insulin resistance in mice.
Prolonged fasting elicits increased hepatic triglyceride accumulation in rats born to dexamethasone-treated mothers.
Glycosuria
Thyroid hormone treatment decreases hepatic glucose production and renal reabsorption of glucose in alloxan-induced diabetic Wistar rats.
Hepatitis B
Direct binding of hepatitis B virus X protein and retinoid X receptor contributes to phosphoenolpyruvate carboxykinase gene transactivation.
Increased expression of phosphoenolpyruvate carboxykinase cytoplasmic isoform by hepatitis B virus X protein affects hepatitis B virus replication.
Hepatitis C
Increased expression and activity of the transcription factor FOXO1 in nonalcoholic steatohepatitis.
Increased Phosphoenolpyruvate Carboxykinase (PEPCK) Gene Expression and Steatosis During Hepatitis C Virus (HCV) Subgenome Replication: Role of Nonstructural Component-5A (NS5A) and CCAAT/Enhancer Binding Protein ?(C/EBP?).
Hepatitis, Chronic
Increased expression and activity of the transcription factor FOXO1 in nonalcoholic steatohepatitis.
Hepatoblastoma
Regulation by glucagon (cAMP) and insulin of the promoter of the human phosphoenolpyruvate carboxykinase gene (cytosolic) in cultured rat hepatocytes and in human hepatoblastoma cells.
Herpes Simplex
Characterization of the phosphoenolpyruvate carboxykinase (GTP) promoter-regulatory region. I. Multiple hormone regulatory elements and the effects of enhancers.
Characterization of the phosphoenolpyruvate carboxykinase (GTP) promoter-regulatory region. II. Identification of cAMP and glucocorticoid regulatory domains.
Identification of a cAMP regulatory region in the gene for rat cytosolic phosphoenolpyruvate carboxykinase (GTP). Use of chimeric genes transfected into hepatoma cells.
Image-aided Suicide Gene Therapy Utilizing Multifunctional hTERT-targeting Adenovirus for Clinical Translation in Hepatocellular Carcinoma.
The role of the TATA box in the hormonal regulation of phosphoenolpyruvate carboxykinase gene expression.
Herpes Zoster
Establishment and characterisation of a novel bovine SV40 large T-antigen-transduced foetal hepatocyte-derived cell line.
Hyperglycemia
A high-throughput assay for modulators of mitochondrial membrane potential identifies a novel compound with beneficial effects on db/db mice.
A new transgenic rat model of hepatic steatosis and the metabolic syndrome.
A potential probiotic bacterium for antipsychotic-induced metabolic syndrome: mechanisms underpinning how Akkermansia muciniphila subtype improves olanzapine-induced glucose homeostasis in mice.
A synthetic Nitraria alkaloid, isonitramine protects pancreatic ?-cell and attenuates postprandial hyperglycemia.
An afferent vagal nerve pathway links hepatic PPARalpha activation to glucocorticoid-induced insulin resistance and hypertension.
Anti-diabetic effects of new herbal formula in neonatally streptozotocin-induced diabetic rats.
Antidiabetic and Antihyperlipidemic Properties of a Triterpenoid Compound, Dehydroeburicoic Acid, from Antrodia camphorata in Vitro and in Streptozotocin-Induced Mice.
Biochemical evidence on the potential role of organophosphates in hepatic glucose metabolism toward insulin resistance through inflammatory signaling and free radical pathways.
Carbon flux via the pentose phosphate pathway regulates the hepatic expression of the glucose-6-phosphatase and phosphoenolpyruvate carboxykinase genes in conscious rats.
Carotid body denervation prevents fasting hyperglycemia during chronic intermittent hypoxia.
Central Administration of Resveratrol Improves Diet-Induced Diabetes.
Chronic hyperglycemia enhances PEPCK gene expression and hepatocellular glucose production via elevated liver activating protein/liver inhibitory protein ratio.
Crystal structure of human cytosolic phosphoenolpyruvate carboxykinase reveals a new GTP-binding site.
Effects of dieldrin on hepatic carbohydrate metabolism in the suckling and adult rat.
ERK1/2 pathway is involved in renal gluconeogenesis inhibition under conditions of lowered NADPH oxidase activity.
Exercise maintains euglycemia in association with decreased activation of c-Jun NH2-terminal kinase and serine phosphorylation of IRS-1 in the liver of ZDF rats.
Fasting hyperglycemia is not associated with increased expression of PEPCK or G6Pc in patients with Type 2 Diabetes.
Generation of fibroblasts overexpressing liver-specific PEPCK in a miniature pig model of human type 2 diabetes mellitus.
Glucagon receptor antibody completely suppresses type 1 diabetes phenotype without insulin by disrupting a novel diabetogenic pathway.
Hepatic phosphoenolpyruvate carboxykinase expression after gastric bypass surgery in rats with type 2 diabetes mellitus.
Histone Methylation of H3K4 Involved in the Anorexia of Carnivorous Mandarin Fish (Siniperca chuatsi) After Feeding on a Carbohydrate-Rich Diet.
Hyperglycemia associated with increased hepatic glycogen phosphorylase and phosphoenolpyruvate carboxykinase in rats following subchronic exposure to malathion.
Impaired oxidative phosphorylation in hepatic mitochondria in growth-retarded rats.
Intergenerational consequences of fetal programming by in utero exposure to glucocorticoids in rats.
Liver-specific iNOS expression is sufficient to cause hepatic insulin resistance and mild hyperglycemia in mice.
Liver-specific overexpression of pancreatic-derived factor (PANDER) induces fasting hyperglycemia in mice.
Mechanisms by which bis(maltolato)oxovanadium(IV) normalizes phosphoenolpyruvate carboxykinase and glucose-6-phosphatase expression in streptozotocin-diabetic rats in vivo.
Mechanisms by which liver-specific PEPCK knockout mice preserve euglycemia during starvation.
Nicotinic acetylcholine receptors in glucose homeostasis: the acute hyperglycemic and chronic insulin-sensitive effects of nicotine suggest dual opposing roles of the receptors in male mice.
Overcoming diabetes-induced hyperglycemia through inhibition of hepatic phosphoenolpyruvate carboxykinase (GTP) with RNAi.
Par14 protein associates with insulin receptor substrate 1 (IRS-1), thereby enhancing insulin-induced IRS-1 phosphorylation and metabolic actions.
Paternal obesity impairs hepatic gluconeogenesis of offspring by altering Igf2/H19 DNA methylation.
Paternal Psychological Stress Reprograms Hepatic Gluconeogenesis in Offspring.
Phosphoenolpyruvate carboxykinase (GTP) gene transcription and hyperglycemia are regulated by glucocorticoids in genetically obese db/db transgenic mice.
Phosphoenolpyruvate carboxykinase in urine exosomes reflect impairment in renal gluconeogenesis in early insulin resistance and diabetes.
Pin1 associates with and induces translocation of CRTC2 to the cytosol, thereby suppressing cAMP-responsive element transcriptional activity.
Protection by pentoxifylline of diazinon-induced toxic stress in rat liver and muscle.
Renal enzymes during experimental diabetes mellitus in the rat. Role of insulin, carbohydrate metabolism, and ketoacidosis.
Rosmarinic acid ameliorates hyperglycemia and insulin sensitivity in diabetic rats, potentially by modulating the expression of PEPCK and GLUT4.
Specific reduction of G6PT may contribute to downregulation of hepatic 11?-HSD1 in diabetic mice.
Synthetic FXR Agonist GW4064 Prevents Diet-Induced Hepatic Steatosis and Insulin Resistance.
The effect of prolonged hyperglycemia on metabolic alterations in the subtotally pancreatectomized rat.
The phosphorylation state of the cAMP response element binding protein is decreased in diabetic rat liver.
The transcription factor CCAAT/enhancer-binding protein beta regulates gluconeogenesis and phosphoenolpyruvate carboxykinase (GTP) gene transcription during diabetes.
Transcription of hepatic cytosolic phosphoenolpyruvate carboxykinase gene in newborn dogs.
Vanadate normalizes hyperglycemia and phosphoenolpyruvate carboxykinase mRNA levels in ob/ob mice.
Zhenqing recipe improves glucose metabolism and insulin sensitivity by repressing hepatic FOXO1 in type 2 diabetic rats.
Hyperhomocysteinemia
Hyperhomocysteinemia stimulates hepatic glucose output and PEPCK expression.
Hyperinsulinism
A new transgenic rat model of hepatic steatosis and the metabolic syndrome.
An afferent vagal nerve pathway links hepatic PPARalpha activation to glucocorticoid-induced insulin resistance and hypertension.
Changing pattern of prevalence of insulin resistance in Psammomys obesus, a model of nutritionally induced type 2 diabetes.
Chronic hyperinsulinemia in the fetal rhesus monkey: effects of physiologic hyperinsulinemia on fetal substrates, hormones, and hepatic enzymes.
Differential hepatic gene expression in a polygenic mouse model with insulin resistance and hyperglycemia: evidence for a combined transcriptional dysregulation of gluconeogenesis and fatty acid synthesis.
Down-regulation of hepatic phosphoenolpyruvate carboxykinase expression in magnesium-deficient rats.
Hepatic insulin resistance induced by chronic hindlimb ischemia.
Impaired glucose tolerance and increased weight gain in transgenic rats overexpressing a non-insulin-responsive phosphoenolpyruvate carboxykinase gene.
Inactivation of the adrenergic receptor ?2 disrupts glucose homeostasis in mice.
Increased insulin receptor substrate-1 and enhanced skeletal muscle insulin sensitivity in mice lacking CCAAT/enhancer-binding protein beta.
Intergenerational consequences of fetal programming by in utero exposure to glucocorticoids in rats.
Irreversibility of nutritionally induced NIDDM in Psammomys obesus is related to beta-cell apoptosis.
Mice lacking thioredoxin-interacting protein provide evidence linking cellular redox state to appropriate response to nutritional signals.
Mitochondrial glycerol-3-phosphate acyltransferase-1 is essential in liver for the metabolism of excess acyl-CoAs.
Molecular characterization of insulin-mediated suppression of hepatic glucose production in vivo R2.
Reciprocal changes in gluconeogenic enzyme activity in liver and kidney by VMH lesion.
Surgical removal of visceral fat reverses hepatic insulin resistance.
Synthetic FXR Agonist GW4064 Prevents Diet-Induced Hepatic Steatosis and Insulin Resistance.
Transcription of hepatic cytosolic phosphoenolpyruvate carboxykinase gene in newborn dogs.
Vanillic acid mitigates the impairments in glucose metabolism in HepG2 cells through BAD-GK interaction during hyperinsulinemia.
Hyperlactatemia
Endotoxin induced hyperlactatemia and hypoglycemia is linked to decreased mitochondrial phosphoenolpyruvate carboxykinase.
Hyperlipidemias
Ergostatrien-3?-ol from Antrodia camphorata Inhibits Diabetes and Hyperlipidemia in High-Fat-Diet Treated Mice via Regulation of Hepatic Related Genes, Glucose Transporter 4, and AMP-Activated Protein Kinase Phosphorylation.
Hypersensitivity
Impairment of insulin-stimulated glucose transport and ERK activation by adipocyte-specific knockout of PKC-? produces a phenotype characterized by diminished adiposity and enhanced insulin suppression of hepatic gluconeogenesis.
Hypertension
Acute effect of whey peptides upon blood pressure of hypertensive rats, and relationship with their angiotensin-converting enzyme inhibitory activity.
Proximal tubular-targeted overexpression of the Cyp4a12-20-HETE synthase promotes salt-sensitive hypertension in male mice.
The antihypertensive and cardiac hemodynamic effects of nebivolol.
Hyperthyroidism
3,5,3'-Triiodothyronine-induced synthesis of rat liver phosphoenolpyruvate carboxykinase.
Cooperative effect of thyroid and glucocorticoid hormones on the induction of hepatic phosphoenolpyruvate carboxykinase in vivo and in cultured hepatocytes.
Effect of thyroid state on cyclic AMP-mediated induction of hepatic phosphoenolpyruvate carboxykinase.
Effects of hyperthyroidism on expression of a phosphoenolpyruvate carboxykinase/bovine growth hormone gene in transgenic mice.
Renal phosphoenolpyruvate carboxykinase turnover in hypo- and hyperthyroid rat in vivo.
Thyroid hormone regulates transcription of the gene for cytosolic phosphoenolpyruvate carboxykinase (GTP) in rat liver.
Hypertriglyceridemia
A new transgenic rat model of hepatic steatosis and the metabolic syndrome.
Hypoglycemia
A central role of RLIP76 in regulation of glycemic control.
Carbohydrate metabolism in temporal and persistent hypoglycemic chickens induced by insulin infusion.
Changing pattern of prevalence of insulin resistance in Psammomys obesus, a model of nutritionally induced type 2 diabetes.
Chronic late-gestation hypoglycemia upregulates hepatic PEPCK associated with increased PGC1alpha mRNA and phosphorylated CREB in fetal sheep.
CRTC2 (TORC2) contributes to the transcriptional response to fasting in the liver but is not required for the maintenance of glucose homeostasis.
Cytosolic Phosphoenolpyruvate Carboxykinase Deficiency: Cause of Hypoglycemia-Induced Seizure and Death.
Decreased serum glucose and glycosylated hemoglobin levels in patients with Chuvash polycythemia: a role for HIF in glucose metabolism.
Differential effects of insulin-like growth factor-1 on neonatal canine gene expression.
Disrupted signaling and inhibited regeneration in obese mice with fatty livers: implications for nonalcoholic fatty liver disease pathophysiology.
Down regulation of hepatic glucocorticoid receptors after endotoxin treatment.
Endotoxin induced hyperlactatemia and hypoglycemia is linked to decreased mitochondrial phosphoenolpyruvate carboxykinase.
Hypoglycemia and impaired hepatic glucose production in mice with a deletion of the C/EBPbeta gene.
Hypoglycemia in the newborn growth-retarded rat: delayed phosphoenolpyruvate carboxykinase induction despite increased glucagon availability.
In vivo phosphoenolpyruvate carboxykinase promoter mapping identifies disrupted hormonal synergism as a target of inflammation during sepsis in mice.
Induction of cytosolic phosphoenolpyruvate carboxykinase in the ovine fetal liver by chronic fetal hypoglycemia and hypoinsulinemia.
Influence of endotoxin treatment on dexamethasone induction of hepatic phosphoenolpyruvate carboxykinase.
Novel homozygous PCK1 mutation causing cytosolic phosphoenolpyruvate carboxykinase deficiency presenting as childhood hypoglycemia, an abnormal pattern of urine metabolites and liver dysfunction.
Novel missense variants in PCK1 gene cause cytosolic PEPCK deficiency with growth failure from inadequate caloric intake.
Nuclear corepressor is required for inhibition of phosphoenolpyruvate carboxykinase expression by tumor necrosis factor-alpha.
PEPCK-C reexpression in the liver counters neonatal hypoglycemia in Pck1 (del/del) mice, unmasking role in non-gluconeogenic tissues.
Pharmacological effects of biotin.
Postnatal profiles of glycogenolysis and gluconeogenesis are modified in rat pups by maternal dietary glucose restriction.
Regulation of Gluconeogenesis by Aldo-keto-reductase 1a1b in Zebrafish.
Role of the isoforms of CCAAT/enhancer-binding protein in the initiation of phosphoenolpyruvate carboxykinase (GTP) gene transcription at birth.
Sudden infant death and liver phosphoenolpyruvate carboxykinase analysis.
Synaptic glutamate release by ventromedial hypothalamic neurons is part of the neurocircuitry that prevents hypoglycemia.
The reversal of increased gluconeogenesis in the tumor-bearing rat by tumor removal and food intake.
The role of chicken ovalbumin upstream promoter transcription factor II in the regulation of hepatic fatty acid oxidation and gluconeogenesis in newborn mice.
Tumor necrosis factor-alpha alters glucose metabolism in suckling rats.
Upregulation of hepatic glucose 6-phosphatase gene expression in rats treated with an inhibitor of glucose-6-phosphate translocase.
Hypothyroidism
Cooperative effect of thyroid and glucocorticoid hormones on the induction of hepatic phosphoenolpyruvate carboxykinase in vivo and in cultured hepatocytes.
Infarction, Middle Cerebral Artery
Phosphoenolpyruvate Carboxykinase (PCK) in the Brain Gluconeogenic Pathway Contributes to Oxidative and Lactic Injury After Stroke.
Infections
Activities of key enzymes in the C4 pathway and anatomy of sugarcane infected by Leifsoniaxyli subsp. xyli.
Analyses of phosphoenolpyruvate carboxylase gene structure and expression in alfalfa nodules.
Differential patterns of liver proteins in experimental murine hepatosplenic schistosomiasis.
Dual specificity MAPK phosphatase 3 activates PEPCK gene transcription and increases gluconeogenesis in rat hepatoma cells.
Glucokinase expression in rat hepatoma cells induces glucose uptake and is rate limiting in glucose utilization.
Gluconeogenic carbon flow of tricarboxylic acid cycle intermediates is critical for Mycobacterium tuberculosis to establish and maintain infection.
Hepatic gene transfer in animals using retroviruses containing the promoter from the gene for phosphoenolpyruvate carboxykinase.
Hormonal regulation of chimeric genes containing the phosphoenolpyruvate carboxykinase promoter regulatory region in hepatoma cells infected by murine retroviruses.
Increased Phosphoenolpyruvate Carboxykinase (PEPCK) Gene Expression and Steatosis During Hepatitis C Virus (HCV) Subgenome Replication: Role of Nonstructural Component-5A (NS5A) and CCAAT/Enhancer Binding Protein ?(C/EBP?).
Inhibition of hepatic phosphoenolpyruvate carboxykinase by avian reticuloendotheliosis viruses.
Insulin regulation of phosphoenolpyruvate carboxykinase gene expression does not require activation of the Ras/mitogen-activated protein kinase signaling pathway.
Integrated Metabolomics, Transcriptomics and Proteomics Identifies Metabolic Pathways Affected by Anaplasma phagocytophilum Infection in Tick Cells.
Ionotropic Purinergic Receptors P2X4 and P2X7: Proviral or Antiviral? An Insight into P2X Receptor Signaling and Hepatitis C Virus Infection.
Link between Heterotrophic Carbon Fixation and Virulence in the Porcine Lung Pathogen Actinobacillus pleuropneumoniae.
Molecular mechanism of hepatitis C virus-induced glucose metabolic disorders.
pckA-deficient Mycobacterium bovis BCG shows attenuated virulence in mice and in macrophages.
Regulation of phosphoenolpyruvate carboxylase in PVY(NTN)-infected tobacco plants.
Structural and functional studies of phosphoenolpyruvate carboxykinase from Mycobacterium tuberculosis.
Vanadate inhibits expression of the gene for phosphoenolpyruvate carboxykinase (GTP) in rat hepatoma cells.
Insulin Resistance
A potential probiotic bacterium for antipsychotic-induced metabolic syndrome: mechanisms underpinning how Akkermansia muciniphila subtype improves olanzapine-induced glucose homeostasis in mice.
A primary defect in glucose production alone cannot induce glucose intolerance without defects in insulin secretion.
Absence of melatonin induces night-time hepatic insulin resistance and increased gluconeogenesis due to stimulation of nocturnal unfolded protein response.
Adiponectin and its receptors in patients with chronic hepatitis C.
Adipose overexpression of phosphoenolpyruvate carboxykinase leads to high susceptibility to diet-induced insulin resistance and obesity.
Amelioration of glucose homeostasis by glycyrrhizic acid through gluconeogenesis rate-limiting enzymes.
An afferent vagal nerve pathway links hepatic PPARalpha activation to glucocorticoid-induced insulin resistance and hypertension.
Anti-diabetic effects of new herbal formula in neonatally streptozotocin-induced diabetic rats.
Arrestin domain-containing 3 (Arrdc3) modulates insulin action and glucose metabolism in liver.
AS160 deficiency causes whole-body insulin resistance via composite effects in multiple tissues.
Beneficial effects of Aronia melanocarpa berry extract on hepatic insulin resistance in type 2 diabetes mellitus rats.
Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis.
Corticosterone-induced insulin resistance is not associated with alterations of insulin receptor number and kinase activity in chicken kidney.
Dapagliflozin improves insulin resistance and glucose intolerance in a novel transgenic rat model of chronic glucose overproduction and glucose toxicity.
Dynamic Behavior of Rat Phosphoenolpyruvate Carboxykinase Inhibitors: New Mechanism for Enzyme Inhibition.
Effect of oxymatrine on liver gluconeogenesis is associated with the regulation of PEPCK and G6Pase expression and AKT phosphorylation.
Effect of trivalent chromium on erythropoietin production and the prevention of insulin resistance in HepG2 cells.
Effects of intravenous AICAR (5-aminoimidazole-4-carboximide riboside) administration on insulin signaling and resistance in premature baboons, Papio sp.
Emodin, a natural product, selectively inhibits 11beta-hydroxysteroid dehydrogenase type 1 and ameliorates metabolic disorder in diet-induced obese mice.
Examination of the phosphoenolpyruvate carboxykinase gene promoter in patients with noninsulin-dependent diabetes mellitus.
Exercise maintains euglycemia in association with decreased activation of c-Jun NH2-terminal kinase and serine phosphorylation of IRS-1 in the liver of ZDF rats.
Expression of subcutaneous adipose tissue phosphoenolpyruvate carboxykinase correlates with body mass index in nondiabetic women.
Flavin-Containing Monooxygenase 3 Reduces Endoplasmic Reticulum Stress in Lipid-Treated Hepatocytes.
Gene-nutrient interactions on the phosphoenolpyruvate carboxykinase influence insulin sensitivity in metabolic syndrome subjects.
Glucagon-like peptide-1 gene therapy in obese diabetic mice results in long-term cure of diabetes by improving insulin sensitivity and reducing hepatic gluconeogenesis.
Hawthorn polyphenols, D-chiro-inositol, and epigallocatechin gallate exert a synergistic hypoglycemic effect.
Hepatic Bax inhibitor-1 inhibits IRE1alpha and protects from obesity-associated insulin resistance and glucose intolerance.
Hepatic insulin resistance induced by chronic hindlimb ischemia.
Hepatitis C virus infection and insulin resistance.
High-Efficacy ?,?-Dehydromonacolin S Improves Hepatic Steatosis and Suppresses Gluconeogenesis Pathway in High-Fat Diet-Induced Obese Rats.
Hyperhomocysteinemia stimulates hepatic glucose output and PEPCK expression.
Increased expression and activity of the transcription factor FOXO1 in nonalcoholic steatohepatitis.
Increased fatty acid re-esterification by PEPCK overexpression in adipose tissue leads to obesity without insulin resistance.
Increased glucocorticoid receptor and 11{beta}-hydroxysteroid dehydrogenase type 1 expression in hepatocytes may contribute to the phenotype of type 2 diabetes in db/db mice.
Increased hypothalamic-pituitary-adrenal axis activity and hepatic insulin resistance in low-birth-weight rats.
Increased nucleobindin-2 (NUCB2) transcriptional activity links the regulation of insulin sensitivity in type 2 diabetes mellitus.
Increased Phosphoenolpyruvate Carboxykinase (PEPCK) Gene Expression and Steatosis During Hepatitis C Virus (HCV) Subgenome Replication: Role of Nonstructural Component-5A (NS5A) and CCAAT/Enhancer Binding Protein ?(C/EBP?).
Inducible nitric oxide synthase plays a role in LPS-induced hyperglycemia and insulin resistance.
Inhibition of NF-?B Reduces Renal Inflammation and Expression of PEPCK in Type 2 Diabetic Mice.
Inhibition of obesity-induced hepatic ER stress by early insulin therapy in obese diabetic rats.
Insulin resistance of gluconeogenic pathways in neonatal rats after prenatal ethanol exposure.
Intermittent fasting reduces body fat but exacerbates hepatic insulin resistance in young rats regardless of high protein and fat diets.
Irisin inhibits hepatic gluconeogenesis and increases glycogen synthesis via the PI3K/Akt pathway in type 2 diabetic mice and hepatocytes.
Irreversibility of nutritionally induced NIDDM in Psammomys obesus is related to beta-cell apoptosis.
IRS-1/PI3K/Akt pathway and miRNAs are involved in whole grain highland barley (Hordeum vulgare L.) ameliorating hyperglycemia of db/db mice.
Jerusalem artichoke and chungkookjang additively improve insulin secretion and sensitivity in diabetic rats.
Kochujang, a Korean fermented red pepper plus soybean paste, improves glucose homeostasis in 90% pancreatectomized diabetic rats.
Linkage analysis of 19 candidate regions for insulin resistance in familial NIDDM.
Merit of physical exercise to reverse the higher gene expression of hepatic phosphoenolpyruvate carboxykinase in obese Zucker rats.
Mibefradil reduces hepatic glucose output in HepG2 cells via Ca2+/calmodulin-dependent protein kinase II-dependent Akt/forkhead box O1signaling.
MicroRNA-351 eases insulin resistance and liver gluconeogenesis via the PI3K/AKT pathway by inhibiting FLOT2 in mice of gestational diabetes mellitus.
Naringin ameliorates metabolic syndrome by activating AMP-activated protein kinase in mice fed a high-fat diet.
New approach in the treatment of T2DM and metabolic syndrome (focus on a novel insulin sensitizer).
Peripheral insulin resistance develops in transgenic rats overexpressing phosphoenolpyruvate carboxykinase in the kidney.
Phosphoenolpyruvate carboxykinase (Pck1) in hepatic and adipose tissue contributes to the regulation of the triglyceride fatty acid cycle and development of insulin resistance in mice.
Phosphoenolpyruvate carboxykinase in urine exosomes reflect impairment in renal gluconeogenesis in early insulin resistance and diabetes.
Phosphoenolpyruvate carboxykinase overexpression selectively attenuates insulin signaling and hepatic insulin sensitivity in transgenic mice.
Reduced Milk Triglycerides in Mice Lacking Phosphoenolpyruvate Carboxykinase in Mammary Gland Adipocytes and White Adipose Tissue Contribute to the Development of Insulin Resistance in Pups.
Regulation of the acid-labile subunit in sustained endotoxemia.
Renal Denervation Reverses Hepatic Insulin Resistance Induced by High-Fat Diet.
Role of retinol-binding protein 4 in the pathogenesis of Type 2 diabetes.
Rosmarinic acid ameliorates hyperglycemia and insulin sensitivity in diabetic rats, potentially by modulating the expression of PEPCK and GLUT4.
SIK1 Regulates CRTC2-Mediated Gluconeogenesis Signaling Pathway in Human and Mouse Liver Cells.
Silencing of FGF-21 expression promotes hepatic gluconeogenesis and glycogenolysis by regulation of the STAT3-SOCS3 signal.
Specific reduction of G6PT may contribute to downregulation of hepatic 11?-HSD1 in diabetic mice.
Surgical removal of visceral fat reverses hepatic insulin resistance.
TCTP participates in hepatic metabolism by regulating gene expression involved in insulin resistance.
Telmisartan is effective to ameliorate metabolic syndrome in rat model - a preclinical report.
The characteristics of hepatic Gs?-cAMP axis in HSHF diet-fed obese insulin resistance rats and genetic diabetic mice.
Transcription factor TIP27 regulates glucose homeostasis and insulin sensitivity in a PI3-kinase/Akt-dependent manner in mice.
Transgenic Mice Overexpressing SREBP-1a in Male ob/ob Mice Exhibit Lipodystrophy and Exacerbate Insulin Resistance.
Transgenic mice overexpressing SREBP-1a under the control of the PEPCK promoter exhibit insulin resistance, but not diabetes.
Treatment with an SSRI antidepressant restores hippocampo-hypothalamic corticosteroid feedback and reverses insulin resistance in low-birth-weight rats.
Zingiber mioga reduces weight gain, insulin resistance and hepatic gluconeogenesis in diet-induced obese mice.
[Effect of intrauterine growth retardation on gluconeogenic enzymes in rat liver].
[Effects of Astragalus membranaceus and Potentilla discolor mixture on insulin resistance and its related mRNA expressions in KKAy mice with type 2 diabetes].
[Increased expression of gluconeogenic enzymes in the liver of IUGR rats and subsequent insulin resistance]
[Relationship between adipose phosphoenolpyruvate carboxykinase and occurrence and reversion of insulin resistance]
Intestinal Volvulus
Phosphoenolpyruvate carboxykinase from Onchocerca volvulus and O. gibsoni.
Iron Deficiencies
Iron Deficiency and the Structure and Physiology of Maize Chloroplasts.
Metabolic changes of iron uptake in N(2)-fixing common bean nodules during iron deficiency.
Metabolic changes of iron uptake in N?-fixing common bean nodules during iron deficiency
Metabolic response in roots of Prunus rootstocks submitted to iron chlorosis.
Phosphoenolpyruvate carboxylase in cucumber (Cucumis sativus L.) roots under iron deficiency: activity and kinetic characterization.
Ketosis
Effect of insulin-like growth factor-1 (IGF-1) on the gluconeogenesis in calf hepatocytes cultured in vitro.
Regulation of messenger ribonucleic acid expression for gluconeogenic enzymes during glucagon infusions into lactating cows.
Renal enzymes during experimental diabetes mellitus in the rat. Role of insulin, carbohydrate metabolism, and ketoacidosis.
Leishmaniasis
Identification of broadly conserved cross-species protective Leishmania antigen and its responding CD4+ T cells.
Leprosy
Intracellular Mycobacterium leprae Utilizes Host Glucose as a Carbon Source in Schwann Cells.
Leukemia
Lithium inhibits hepatic gluconeogenesis and phosphoenolpyruvate carboxykinase gene expression.
Quantitative evaluation of liver-specific promoters from retroviral vectors after in vivo transduction of hepatocytes.
Vanadate inhibits expression of the gene for phosphoenolpyruvate carboxykinase (GTP) in rat hepatoma cells.
Liver Cirrhosis
Hepatic gluconeogenic key enzymes in patients with hepatic cancer.
Liver Diseases
Novel homozygous PCK1 mutation causing cytosolic phosphoenolpyruvate carboxykinase deficiency presenting as childhood hypoglycemia, an abnormal pattern of urine metabolites and liver dysfunction.
Stimulation of rat kidney phosphoenolpyruvate carboxykinase activity in experimental liver disease induced by galactosamine.
The roles of ATF3 in liver dysfunction and the regulation of phosphoenolpyruvate carboxykinase gene expression.
Liver Failure
Cytosolic phosphoenolpyruvate carboxykinase deficiency presenting with acute liver failure following gastroenteritis.
Mitochondrial phosphoenolpyruvate carboxykinase deficiency.
Novel missense variants in PCK1 gene cause cytosolic PEPCK deficiency with growth failure from inadequate caloric intake.
Liver Failure, Acute
Cytosolic phosphoenolpyruvate carboxykinase deficiency presenting with acute liver failure following gastroenteritis.
[The effect of endotoxemia on gluconeogenesis in livers and kidneys during acute hepatic failure.]
Liver Neoplasms
Hepatic gluconeogenic key enzymes in patients with hepatic cancer.
Image-aided Suicide Gene Therapy Utilizing Multifunctional hTERT-targeting Adenovirus for Clinical Translation in Hepatocellular Carcinoma.
TCF7L2 involvement in estradiol- and progesterone-modulated islet and hepatic glucose homeostasis.
Lung Neoplasms
Distribution and prognostic significance of gluconeogenesis and glycolysis in lung cancer.
PCK2 activation mediates an adaptive response to glucose depletion in lung cancer.
Lymphopenia
Reduction of hepatic and adipose tissue glucocorticoid receptor expression with antisense oligonucleotides improves hyperglycemia and hyperlipidemia in diabetic rodents without causing systemic glucocorticoid antagonism.
Magnesium Deficiency
Down-regulation of hepatic phosphoenolpyruvate carboxykinase expression in magnesium-deficient rats.
Hepatic gluconeogenic enzymes, plasma insulin and glucagon response to magnesium deficiency and fasting.
Malaria
Suppression of experimental cerebral malaria by disruption of malate:quinone oxidoreductase.
Marek Disease
Genetic variability of the cytosolic phosphoenolpyruvate carboxykinase gene in white leghorn chickens.
Mitochondrial PEPCK: a highly polymorphic gene with alleles co-selected with Marek's disease resistance in chickens.
Melanoma
Upregulation of cytosolic phosphoenolpyruvate carboxykinase is a critical metabolic event in melanoma cells that repopulate tumors.
Metabolic Diseases
Lactobacillus acidophilus NS1 Reduces Phosphoenolpyruvate Carboxylase Expression by Regulating HNF4? Transcriptional Activity.
Metabolic Syndrome
A new transgenic rat model of hepatic steatosis and the metabolic syndrome.
Amelioration of glucose homeostasis by glycyrrhizic acid through gluconeogenesis rate-limiting enzymes.
Antiresistin RNA Oligonucleotide Ameliorates Diet-Induced Nonalcoholic Fatty Liver Disease in Mice through Attenuating Proinflammatory Cytokines.
Gene-nutrient interactions on the phosphoenolpyruvate carboxykinase influence insulin sensitivity in metabolic syndrome subjects.
Impaired Cavernous Reinnervation after Penile Nerve Injury in Rats with Features of the Metabolic Syndrome.
Liver upregulation of genes involved in cortisol production and action is associated with metabolic syndrome in morbidly obese patients.
Proposed involvement of adipocyte glyceroneogenesis and phosphoenolpyruvate carboxykinase in the metabolic syndrome.
Neoplasm Metastasis
Distribution and prognostic significance of gluconeogenesis and glycolysis in lung cancer.
High Expression of PQBP1 and Low Expression of PCK2 are Associated with Metastasis and Recurrence of Osteosarcoma and Unfavorable Survival Outcomes of the Patients.
Neoplasms
A newly discovered role of metabolic enzyme PCK1 as a protein kinase to promote cancer lipogenesis.
Anti-diabetic potential of alkaloid rich fraction from Capparis decidua on diabetic mice.
Bcl-2 inhibits tumor necrosis factor-alpha-mediated increase of glycolytic enzyme activities and enhances pyruvate carboxylase activity.
Biochemical evidence on the potential role of organophosphates in hepatic glucose metabolism toward insulin resistance through inflammatory signaling and free radical pathways.
Cancer Cells Hijack Gluconeogenic Enzymes to Fuel Cell Growth.
Computational evaluation of natural compounds as potential inhibitors of human PEPCK-M: an alternative for lung cancer therapy.
Current treatment of insulin resistance in type 2 diabetes mellitus.
Distinction of seventy-one cultured human tumor cell lines by polymorphic enzyme analysis.
Distribution and prognostic significance of gluconeogenesis and glycolysis in lung cancer.
Down-regulation of the phosphoenolpyruvate carboxykinase gene in human colon tumors and induction by omega-3 fatty acids.
Downregulation of PCK2 remodels tricarboxylic acid cycle in tumor-repopulating cells of melanoma.
Effect of dexamethasone on NF-kB activation, tumor necrosis factor formation, and glucose dyshomeostasis in septic rats.
Effect of tumor necrosis factor on enzymes of gluconeogenesis in the rat.
Erythropoietin inhibits gluconeogenesis and inflammation in the liver and improves glucose intolerance in high-fat diet-fed mice.
Expression of two androgen-induced proteins (pepsinogen C and apolipoprotein d) in epithelial skin cancers of the eyelids.
Extended culturing of androgen-responsive human primary epithelial prostate cell isolates by continuous treatment with interstitial collagenase.
Gluconeogenesis in cancer cells - Repurposing of a starvation-induced metabolic pathway?
Gluconeogenesis in Cancer: Function and Regulation of PEPCK, FBPase, and G6Pase.
Hepatitis C virus infection and insulin resistance.
Hydrazine sulfate: a current perspective.
Identification of tumor necrosis factor as a transcriptional regulator of the phosphoenolpyruvate carboxykinase gene following endotoxin treatment of mice.
Immunoenzymatically determined pepsinogen C concentration in breast tumor cytosols: an independent favorable prognostic factor in node-positive patients.
Impairment by interleukin 1 beta and tumour necrosis factor alpha of the glucagon-induced increase in phosphoenolpyruvate carboxykinase gene expression and gluconeogenesis in cultured rat hepatocytes.
Inhibition of gluconeogenesis at the phosphoenolpyruvate carboxykinase and pyruvate carboxylase reactions, as a means of cancer chemotherapy.
Inhibition of hepatic phosphoenolpyruvate carboxykinase by avian reticuloendotheliosis viruses.
Inhibition of phosphoenolpyruvate carboxykinase blocks lactate utilization and impairs tumor growth in colorectal cancer.
Integration of transcriptomic data and metabolic networks in cancer samples reveals highly significant prognostic power.
Intricate Regulation of Phosphoenolpyruvate Carboxykinase (PEPCK) Isoforms in Normal Physiology and Disease.
Liver inflammation and metabolic signaling in ApcMin/+ mice: the role of cachexia progression.
Mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M) is a pro-survival, endoplasmic reticulum (ER) stress response gene involved in tumor cell adaptation to nutrient availability.
Mitochondrial Phosphoenolpyruvate Carboxykinase Regulates Metabolic Adaptation and Enables Glucose-Independent Tumor Growth.
Nuclear corepressor is required for inhibition of phosphoenolpyruvate carboxykinase expression by tumor necrosis factor-alpha.
On the influence of overexpression of phosphoenolpyruvate carboxykinase in Streptomyces lividans on growth and production of human tumour necrosis factor-alpha.
PCK1 Downregulation Promotes TXNRD1 Expression and Hepatoma Cell Growth via the Nrf2/Keap1 Pathway.
PCK2 opposes mitochondrial respiration and maintains the redox balance in starved lung cancer cells.
PEPCK Coordinates the Regulation of Central Carbon Metabolism to Promote Cancer Cell Growth.
PEPCK in cancer cell starvation.
PEPCK-M recoups tumor cell anabolic potential in a PKC-?-dependent manner.
Phosphoenolpyruvate Carboxykinase Maintains Glycolysis-driven Growth in Drosophila Tumors.
Phosphoenolpyruvate from Glycolysis and PEPCK Regulate Cancer Cell Fate by Altering Cytosolic Ca2.
Phytomodulatory proteins promote inhibition of hepatic glucose production and favor glycemic control via the AMPK pathway.
Stat3-mediated activation of miR-23a suppresses gluconeogenesis in hepatocellular carcinoma by downregulating G6PC and PGC-1?
The effects of a biological response modifier, OK-432, on tumor-induced alterations in the host metabolism.
The glycerol backbone of phospholipids derives from noncarbohydrate precursors in starved lung cancer cells.
The reversal of increased gluconeogenesis in the tumor-bearing rat by tumor removal and food intake.
The transcriptomic responses of the ark shell, Anadara broughtonii, to sulfide and hypoxia exposure.
Transcriptome sequencing identifies genes associated with invasion of ovarian cancer.
Tumor-associated metabolic alterations in patients with gastric and esophageal cancer.
Tumorigenicity of simian virus 40-hepatocyte cell lines: effect of in vitro and in vivo passage on expression of liver-specific genes and oncogenes.
Tumour necrosis factor-alpha attenuates insulin action on phosphoenolpyruvate carboxykinase gene expression and gluconeogenesis by altering the cellular localization of Foxa2 in HepG2 cells.
Upregulation of cytosolic phosphoenolpyruvate carboxykinase is a critical metabolic event in melanoma cells that repopulate tumors.
[The role of arecoline on hepatic insulin resistance in type 2 diabetes rats].
Neuroectodermal Tumors, Primitive
Mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M) regulates the cell metabolism of pancreatic neuroendocrine tumors (pNET) and de-sensitizes pNET to mTOR inhibitors.
Neuroendocrine Tumors
Mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M) regulates the cell metabolism of pancreatic neuroendocrine tumors (pNET) and de-sensitizes pNET to mTOR inhibitors.
Non-alcoholic Fatty Liver Disease
Adiponectin is required for pioglitazone-induced improvements in hepatic steatosis in mice fed a high-fat diet.
Antiresistin RNA Oligonucleotide Ameliorates Diet-Induced Nonalcoholic Fatty Liver Disease in Mice through Attenuating Proinflammatory Cytokines.
Post-transcriptional activation of PPAR alpha by KLF6 in hepatic steatosis.
Obesity
Adipose overexpression of phosphoenolpyruvate carboxykinase leads to high susceptibility to diet-induced insulin resistance and obesity.
Association of PCK1 with Body Mass Index and Other Metabolic Features in Patients With Psychotropic Treatments.
Black tea polyphenols mimic insulin/insulin-like growth factor-1 signalling to the longevity factor FOXO1a.
Increased fatty acid re-esterification by PEPCK overexpression in adipose tissue leads to obesity without insulin resistance.
Liver upregulation of genes involved in cortisol production and action is associated with metabolic syndrome in morbidly obese patients.
Novel splice variants of the bovine PCK1 gene.
[Effects of expression of fatty acid synthetase and phosphoenolpyruvate carboxykinase in offspring rats by high protein intake in pregnancy]
Obesity, Abdominal
Effect and the probable mechanisms of silibinin in regulating insulin resistance in the liver of rats with non-alcoholic fatty liver.
Obesity, Morbid
The GID ubiquitin ligase complex is a regulator of AMPK activity and organismal lifespan.
Overnutrition
Impact of maternal overnutrition on gluconeogenic factors and methylation of the phosphoenolpyruvate carboxykinase promoter in the fetal and postnatal liver.
Paralysis
?-Viniferin and resveratrol induced alteration in the activities of some energy metabolism related enzymes in the cestode parasite Raillietina echinobothrida.
Anthelmintic efficacy of Flemingia vestita (Fabaceae): alteration in the activities of some glycolytic enzymes in the cestode, Raillietina echinobothrida.
Peritonitis
Altered levels of mRNA encoding enzymes of hepatic glucose metabolism in septic rats.
Efficacy of anti-tumor necrosis factor polyclonal antibody on phosphoenolpyruvate carboxykinase expression in septic and endotoxemic rats.
phosphoenolpyruvate carboxylase deficiency
Cloning, purification, and properties of a cofactor-independent glutamate racemase from Lactobacillus brevis ATCC 8287.
Cytosolic phosphoenolpyruvate carboxykinase deficiency presenting with acute liver failure following gastroenteritis.
Cytosolic Phosphoenolpyruvate Carboxykinase Deficiency: Cause of Hypoglycemia-Induced Seizure and Death.
Hepatic phosphoenolpyruvate carboxykinase deficiency: a neonatal case with reduced activity of pyruvate carboxylase.
Mitochondrial phosphoenolpyruvate carboxykinase deficiency.
Novel homozygous PCK1 mutation causing cytosolic phosphoenolpyruvate carboxykinase deficiency presenting as childhood hypoglycemia, an abnormal pattern of urine metabolites and liver dysfunction.
Novel missense variants in PCK1 gene cause cytosolic PEPCK deficiency with growth failure from inadequate caloric intake.
The genetic heterogeneity of lactic acidosis: occurrence of recognizable inborn errors of metabolism in pediatric population with lactic acidosis.
Three rare diseases in one Sib pair: RAI1, PCK1, GRIN2B mutations associated with Smith-Magenis Syndrome, cytosolic PEPCK deficiency and NMDA receptor glutamate insensitivity.
Two cases of phosphoenolpyruvate carboxykinase deficiency.
[Phosphoenolpyruvate carboxykinase deficiency]
Porphyria, Acute Intermittent
How porphyrinogenic drugs modeling acute porphyria impair the hormonal status that regulates glucose metabolism. Their relevance in the onset of this disease.
Porphyrias
Hexachlorobenzene as hormonal disruptor--studies about glucocorticoids: their hepatic receptors, adrenal synthesis and plasma levels in relation to impaired gluconeogenesis.
Porphyrias, Hepatic
Response of glucose metabolism enzymes in an acute porphyria model. Role of reactive oxygen species.
Prediabetic State
Phosphoenolpyruvate carboxykinase in urine exosomes reflect impairment in renal gluconeogenesis in early insulin resistance and diabetes.
Prostatic Neoplasms
Glycolytic reprogramming through PCK2 regulates tumor initiation of prostate cancer cells.
protein-tyrosine-phosphatase deficiency
Protein-tyrosine phosphatase 1B deficiency reduces insulin resistance and the diabetic phenotype in mice with polygenic insulin resistance.
pyruvate carboxylase deficiency
Pyruvate carboxylase and phosphoenolpyruvate carboxykinase activity in leukocytes and fibroblasts from a patient with pyruvate carboxylase deficiency.
Pyruvate Carboxylase Deficiency Disease
Pyruvate carboxylase and phosphoenolpyruvate carboxykinase activity in leukocytes and fibroblasts from a patient with pyruvate carboxylase deficiency.
Reticuloendotheliosis, Avian
Inhibition of hepatic phosphoenolpyruvate carboxykinase by avian reticuloendotheliosis viruses.
Retinoblastoma
Adenovirus E1A proteins regulate phosphoenolpyruvate carboxykinase gene transcription through multiple mechanisms.
Sarcoma
Sheep gene mapping: additional DNA markers included (CASB, CASK, LALBA, IGF-1 and AMH).
The reversal of increased gluconeogenesis in the tumor-bearing rat by tumor removal and food intake.
Seizures
Cytosolic Phosphoenolpyruvate Carboxykinase Deficiency: Cause of Hypoglycemia-Induced Seizure and Death.
Sepsis
Altered levels of mRNA encoding enzymes of hepatic glucose metabolism in septic rats.
Berberine reduces gut-vascular barrier permeability via modulation of ApoM/S1P pathway in a model of polymicrobial sepsis.
Effect of dexamethasone on NF-kB activation, tumor necrosis factor formation, and glucose dyshomeostasis in septic rats.
Efficacy of anti-tumor necrosis factor polyclonal antibody on phosphoenolpyruvate carboxykinase expression in septic and endotoxemic rats.
Endotoxin causes reciprocal changes in hepatic nitric oxide synthesis, gluconeogenesis, and flux through phosphoenolpyruvate carboxykinase.
Hepatic gene expression and cytokine responses to sterile inflammation: comparison with cecal ligation and puncture sepsis in the rat.
In vivo phosphoenolpyruvate carboxykinase promoter mapping identifies disrupted hormonal synergism as a target of inflammation during sepsis in mice.
Inhibition of glycerol metabolism in hepatocytes isolated from endotoxic rats.
Sepsis-induced alterations in phosphoenolpyruvate carboxykinase expression: the role of insulin and glucagon.
Shock, Septic
Nuclear corepressor is required for inhibition of phosphoenolpyruvate carboxykinase expression by tumor necrosis factor-alpha.
The effect of iNOS deletion on hepatic gluconeogenesis in hyperdynamic murine septic shock.
Sleep Deprivation
Peripheral and central blockade of interleukin-6 trans-signaling differentially affects sleep architecture.
Smith-Magenis Syndrome
Three rare diseases in one Sib pair: RAI1, PCK1, GRIN2B mutations associated with Smith-Magenis Syndrome, cytosolic PEPCK deficiency and NMDA receptor glutamate insensitivity.
Starvation
11beta-hydroxysteroid dehydrogenase type 1 knockout mice show attenuated glucocorticoid-inducible responses and resist hyperglycemia on obesity or stress.
3,5,3'-Triiodothyronine-induced synthesis of rat liver phosphoenolpyruvate carboxykinase.
A selective autophagy pathway that degrades gluconeogenic enzymes during catabolite inactivation.
Age-dependent glycolysis and gluconeogenesis enzyme activities in starved-refed rats.
Amino acid utilisation in isolated hepatocytes from rainbow trout.
Appropriate leucine supplementation promotes glucose metabolism and enhances energy homeostasis in juvenile crucian carp (Carassius auratus gibelio var. CAS III).
Avian phosphoenolpyruvate carboxykinase: effect of age, starvation and photoperiod.
BHLH32 modulates several biochemical and morphological processes that respond to Pi starvation in Arabidopsis.
Changes in rat hepatic fructose 2,6-bisphosphate and 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase activity during three days of consumption of a high protein diet or starvation.
Characterization and functional analysis of phosphoenolpyruvate carboxylase kinase genes in rice.
Comparison between starvation and consumption of a high protein diet: plasma insulin and glucagon and hepatic activities of gluconeogenic enzymes during the first 24 hours.
Detection and hormonal regulation of the mRNA for cytosolic phosphoenolpyruvate carboxykinase in rat lung.
Distribution along the rat nephron of three enzymes of gluconeogenesis in acidosis and starvation.
Effect of cold exposure on phosphoenolpyruvate carboxykinase (GTP) activity and cyclic amp concentration in livers of starved rats. Role of glucorticoids.
Effect of hibernation on liver and kidney metabolism in 13-lined ground squirrels.
Effect of hormones on transcription of the gene for cytosolic phosphoenolpyruvate carboxykinase (GTP) in rat kidney.
Effect of tumor necrosis factor on enzymes of gluconeogenesis in the rat.
Effects of nutrition and ontogeny on liver cytosolic and mitochondrial phosphoenolpyruvate carboxykinase activity of the rat, hamster, guinea-pig, pig, kid, calf and chick.
Effects of starvation and refeeding a high carbohydrate diet on the intra-acinar distribution pattern of phosphoenolpyruvate carboxykinase activity in the liver of male and female rats.
Glucose deprivation induced upregulation of phosphoenolpyruvate carboxykinase modulates virulence in Leishmania donovani.
Hormonal and nutritional regulation of phosphoenolpyruvate carboxykinase mRNA levels in chicken kidney.
Induction of rat liver phosphoenolpyruvate carbonxykinase (GTP) by cyclic AMP during starvation. The permissive action of glucocorticoids.
Induction of two genes by glucose starvation in hamster fibroblasts.
Inhibition of carbon dioxide fixation by lead acetate in rat liver mitochondria.
Intricate Regulation of Phosphoenolpyruvate Carboxykinase (PEPCK) Isoforms in Normal Physiology and Disease.
Mechanisms by which liver-specific PEPCK knockout mice preserve euglycemia during starvation.
Metabolic adaptation of the renal carbohydrate metabolism. I. Effects of starvation on the gluconeogenic and glycolytic fluxes in the proximal and distal renal tubules.
Metabolic responses in cucumber (Cucumis sativus L.) roots under Fe-deficiency: a 31P-nuclear magnetic resonance in-vivo study.
On the mechanism of gluconeogenesis and its regulation. 3. The glucogenic capacity and the activities of pyruvate carboxylase and PEP-carboxylase of rat kidney and rat liver after cortisol treatment and starvation.
PEPCK in cancer cell starvation.
Phosphate Starvation Inducible ;Bypasses' of Adenylate and Phosphate Dependent Glycolytic Enzymes in Brassica nigra Suspension Cells.
Phosphoenolpyruvate carboxykinase in mouse pancreatic islets. ATP-induced changes in sensitivity to Mn2+ activation.
Phosphoenolpyruvate carboxykinase of rat small intestine: distribution and regulation of activity and mRNA levels.
Phosphoenolpyruvate carboxylase (PEPC) and PEPC-kinase (PEPC-k) isoenzymes in Arabidopsis thaliana: role in control and abiotic stress conditions.
Phosphoenolpyruvate carboxylase in cucumber (Cucumis sativus L.) roots under iron deficiency: activity and kinetic characterization.
Phosphoenolpyruvate from Glycolysis and PEPCK Regulate Cancer Cell Fate by Altering Cytosolic Ca2.
Purification and characterization of phosphoenolpyruvate carboxylase from Brassica napus (rapeseed) suspension cell cultures: implications for phosphoenolpyruvate carboxylase regulation during phosphate starvation, and the integration of glycolysis with nitrogen assimilation.
Rapid changes in the concentration of phosphoenolpyruvate carboxykinase mRNA in rat liver and kidney. Effects of insulin and cyclic AMP.
Regulation of somatostatin gene transcription by cAMP.
Role of small leucine zipper protein in hepatic gluconeogenesis and metabolic disorder.
Subcellular location of phosphoenolpyruvate carboxykinase in hepatocytes from fed and starved rats.
Sugar-Starvation-Induced Changes of Carbon Metabolism in Excised Maize Root Tips.
Synthesis and degradation of phosphoenolpyruvate carboxylase in rat liver and adipose tissue. Changes during a starvation-re-feeding cycle.
The developmental regulation of peroxisome proliferator-activated receptor-gamma coactivator-1alpha expression in the liver is partially dissociated from the control of gluconeogenesis and lipid catabolism.
The response of adult rats weaned prematurely and normally to starvation.
The role of phosphoenolpyruvate carboxykinase in amino acid metabolism in muscle.
Transcriptional and Posttranscriptional Regulation of Nitrogen-Responding Expression of Phosphoenolpyruvate Carboxylase Gene in Maize.
Two isoforms of Pepck in Sarcophaga bullata and their distinct expression profiles through development, diapause, and in response to stresses of cold and starvation.
Utilization of dietary amino acids for energy production in neonatal rat liver.
Vanadate normalizes hyperglycemia and phosphoenolpyruvate carboxykinase mRNA levels in ob/ob mice.
[Enzyme activity of gluconeogenesis in dietary thiamine deficiency]
Stomach Neoplasms
Activated Integrated Stress Response Induced by Salubrinal Promotes Cisplatin Resistance in Human Gastric Cancer Cells via Enhanced xCT Expression and Glutathione Biosynthesis.
Stroke
Hyperglycemia is associated with enhanced gluconeogenesis in a rat model of permanent cerebral ischemia.
Phosphoenolpyruvate Carboxykinase (PCK) in the Brain Gluconeogenic Pathway Contributes to Oxidative and Lactic Injury After Stroke.
Thiamine Deficiency
[Enzyme activity of gluconeogenesis in dietary thiamine deficiency]
Tics
Glycolytic reprogramming through PCK2 regulates tumor initiation of prostate cancer cells.
Tuberculosis
Growth of Mycobacterium tuberculosis at acidic pH depends on lipid assimilation and is accompanied by reduced GAPDH activity.
Methylotrophy in Mycobacteria: Dissection of the Methanol Metabolism Pathway in Mycobacterium smegmatis.
Modulation of Central Carbon Metabolism by Acetylation of Isocitrate Lyase in Mycobacterium tuberculosis.
Mycobacterium Tuberculosis Phosphoenolpyruvate Carboxykinase is Regulated by Redox Mechanisms and Interaction with Thioredoxin.
Production of avirulent mutants of Mycobacterium bovis with vaccine properties by the use of illegitimate recombination and screening of stationary-phase cultures.
Structural and functional studies of phosphoenolpyruvate carboxykinase from Mycobacterium tuberculosis.
The phosphoenolpyruvate carboxykinase of mycobacterium tuberculosis induces strong cell-mediated immune responses in mice.
The Role of Cysteine Residues in Catalysis of Phosphoenolpyruvate Carboxykinase from Mycobacterium tuberculosis.
[Recombinant phosphoenolpyruvate carboxykinase from Mycobacterium tuberculosis for sero diagnosis]
Tuberous Sclerosis
The GID ubiquitin ligase complex is a regulator of AMPK activity and organismal lifespan.
Virus Diseases
A systems medicine approach reveals disordered immune system and lipid metabolism in multiple sclerosis patients.
Expression of phosphoenolpyruvate carboxykinase (PEPCK) chimeras in renal epithelial cells. Retention of appropriate physiological responsiveness using enhancerless retroviral vectors.
Inhibition of hepatic phosphoenolpyruvate carboxykinase by avian reticuloendotheliosis viruses.
Regulation of phosphoenolpyruvate carboxylase in PVY(NTN)-infected tobacco plants.
Vitamin A Deficiency
Effects of vitamin A deficiency and retinoic acid treatment on expression of a phosphoenolpyruvate carboxykinase-bovine growth hormone gene in transgenic mice.
Nuclear receptor binding to the retinoic acid response elements of the phosphoenolpyruvate carboxykinase gene in vivo: effects of vitamin A deficiency.
Retinoid regulation of the phosphoenolpyruvate carboxykinase gene in liver.
RNA polymerase II association with the phosphoenolpyruvate carboxykinase (PEPCK) promoter is reduced in vitamin A-deficient mice.
Vitamin A regulates genes involved in hepatic gluconeogenesis in mice: phosphoenolpyruvate carboxykinase, fructose-1,6-bisphosphatase and 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase.
Vitamin A status in mice affects the histone code of the phosphoenolpyruvate carboxykinase gene in liver.
Whooping Cough
Anisoosmotic regulation of hepatic gene expression.