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Information on EC 4.1.1.28 - aromatic-L-amino-acid decarboxylase and Organism(s) Camptotheca acuminata and UniProt Accession P93082

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EC Tree
     4 Lyases
         4.1 Carbon-carbon lyases
             4.1.1 Carboxy-lyases
                4.1.1.28 aromatic-L-amino-acid decarboxylase
IUBMB Comments
A pyridoxal-phosphate protein. The enzyme also acts on some other aromatic L-amino acids, including L-tryptophan, L-tyrosine and L-phenylalanine.
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This record set is specific for:
Camptotheca acuminata
UNIPROT: P93082
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Word Map
The taxonomic range for the selected organisms is: Camptotheca acuminata
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
dopa decarboxylase, aromatic l-amino acid decarboxylase, aromatic amino acid decarboxylase, tryptophan decarboxylase, l-dopa decarboxylase, l-aromatic amino acid decarboxylase, aromatic-l-amino-acid decarboxylase, l-amino-acid decarboxylase, 3,4-dihydroxyphenylalanine decarboxylase, dopamine decarboxylase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
EC 4.1.1.27
formerly
L-amino acid decarboxylase
-
L-Tryptophan decarboxylase
-
tryptophan decarboxylase-1
-
tryptophan decarboxylase-2
-
3,4-Dihydroxyphenylalanine decarboxylase
-
-
-
-
5-Hydroxy-L-tryptophan decarboxylase
-
-
-
-
5-Hydroxytryptophan decarboxylase
-
-
-
-
AADC
-
-
-
-
Aromatic amino acid decarboxylase
-
-
-
-
Aromatic L-amino acid decarboxylase
-
-
-
-
DDC
-
-
-
-
Decarboxylase, aromatic amino acid
-
-
-
-
Dihydroxyphenylalanine-5-hydroxytryptophan decarboxylase
-
-
-
-
DOPA DC
-
-
-
-
DOPA decarboxylase
-
-
-
-
DOPA-5-hydroxytryptophan decarboxylase
-
-
-
-
Hydroxytryptophan decarboxylase
-
-
-
-
L-3,4-Dihydroxyphenylalanine decarboxylase
-
-
-
-
L-5-Hydroxytryptophan decarboxylase
-
-
-
-
L-Aromatic amino acid decarboxylase
-
-
-
-
L-DOPA decarboxylase
-
-
-
-
L-Tryptophan decarboxylase
-
-
-
-
Tryptophan decarboxylase
-
-
-
-
TYDC
-
-
-
-
Tyrosine/Dopa decarboxylase
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
decarboxylation
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
Aromatic-L-amino-acid carboxy-lyase
A pyridoxal-phosphate protein. The enzyme also acts on some other aromatic L-amino acids, including L-tryptophan, L-tyrosine and L-phenylalanine.
CAS REGISTRY NUMBER
COMMENTARY hide
9042-64-2
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
5-hydroxy-L-tryptophan
5-hydroxytryptamine + CO2
show the reaction diagram
-
-
?
L-tryptophan
tryptamine + CO2
show the reaction diagram
additional information
?
-
exclusive substrate specificity for L-amino acids with either indole or phenol side chains, but not both, L-tyrosine, L-phenylalanine and L-Dopa are not accepted as substrates
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
L-tryptophan
tryptamine + CO2
show the reaction diagram
implicated in the biosynthesis of the plant hormone indole-3-acetic acid, also involved in the formation of the monoamine serotonin, and of simple alkaloids such as the beta-carbolines
-
?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
pyridoxal 5'-phosphate
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
SwissProt
Manually annotated by BRENDA team
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
TDC1_CAMAC
502
0
55495
Swiss-Prot
-
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
two autonomously regulated genes, TDC1 and TDC2
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
pharmacology
biosynthesis of pharmaceutically important monoterpenoid indole alkaloids
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Facchini, P.J.; Huber-Allanach, K.L.; Tari, L.W.
Plant aromatic L-amino acid decarboxylases: evolution, biochemistry, regulation, and metabolic engineering applications
Phytochemistry
54
121-138
2000
Cinchona calisaya, Drosophila melanogaster, Solanum lycopersicum, Sus scrofa, Cinchona officinalis, Catharanthus roseus (P17770), Homo sapiens (P20711), Camptotheca acuminata (P93082)
Manually annotated by BRENDA team