Disease on EC 4.1.1.19 - arginine decarboxylase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Acidosis
PEPCK mRNA localization in proximal tubule and gene regulation during metabolic acidosis.
Brain Edema
Endogenous Agmatine Induced by Ischemic Preconditioning Regulates Ischemic Tolerance Following Cerebral Ischemia.
Carcinoma, Hepatocellular
C/EBP? is AMP kinase sensitive and up-regulates PEPCK in response to ER stress in hepatoma cells.
Dual specificity MAPK phosphatase 3 activates PEPCK gene transcription and increases gluconeogenesis in rat hepatoma cells.
Insulin pulses less effective than continuous insulin in inhibiting PEPCK mRNA levels stimulated by cAMP and dexamethasone in perifused hepatoma cells.
Polyphenolic compounds from Artemisia dracunculus L. inhibit PEPCK gene expression and gluconeogenesis in an H4IIE hepatoma cell line.
Chagas Disease
Inhibition of ornithine or arginine decarboxylase as an experimental approach to African or American trypanosomiasis.
Trypanosoma cruzi as a model system to study the expression of exogenous genes coding for polyamine biosynthetic enzymes. Induction of DFMO resistance in transgenic parasites.
Dehydration
An arginine decarboxylase gene PtADC from Poncirus trifoliata confers abiotic stress tolerance and promotes primary root growth in Arabidopsis.
Involvement of polyamines in the drought resistance of rice.
Molecular cloning and expression analysis of an arginine decarboxylase gene from peach (Prunus persica).
Overexpression of a stress-responsive MYB transcription factor of Poncirus trifoliata confers enhanced dehydration tolerance and increases polyamine biosynthesis.
Overexpression of PtADC confers enhanced dehydration and drought tolerance in transgenic tobacco and tomato: Effect on ROS elimination.
Diabetes Mellitus
Generation of fibroblasts overexpressing liver-specific PEPCK in a miniature pig model of human type 2 diabetes mellitus.
Diabetes Mellitus, Type 2
Fasting hyperglycemia is not associated with increased expression of PEPCK or G6Pc in patients with Type 2 Diabetes.
Generation of fibroblasts overexpressing liver-specific PEPCK in a miniature pig model of human type 2 diabetes mellitus.
Hyperglycemia
Chronic hyperglycemia enhances PEPCK gene expression and hepatocellular glucose production via elevated liver activating protein/liver inhibitory protein ratio.
Fasting hyperglycemia is not associated with increased expression of PEPCK or G6Pc in patients with Type 2 Diabetes.
Rosmarinic acid ameliorates hyperglycemia and insulin sensitivity in diabetic rats, potentially by modulating the expression of PEPCK and GLUT4.
Hyperhomocysteinemia
Hyperhomocysteinemia stimulates hepatic glucose output and PEPCK expression.
Hypoglycemia
Chronic late-gestation hypoglycemia upregulates hepatic PEPCK associated with increased PGC1alpha mRNA and phosphorylated CREB in fetal sheep.
Infection
Apoplastic polyamine oxidation plays different roles in local responses of tobacco to infection by the necrotrophic fungus Sclerotinia sclerotiorum and the biotrophic bacterium Pseudomonas viridiflava.
Engineered polyamine catabolism preinduces tolerance of tobacco to bacteria and oomycetes.
Group A streptococci from invasive-disease episodes in Poland are remarkably divergent at the molecular level.
Polyamine metabolism in flax in response to treatment with pathogenic and non-pathogenic Fusarium strains.
Insulin Resistance
Increased fatty acid re-esterification by PEPCK overexpression in adipose tissue leads to obesity without insulin resistance.
Rosmarinic acid ameliorates hyperglycemia and insulin sensitivity in diabetic rats, potentially by modulating the expression of PEPCK and GLUT4.
Transgenic mice overexpressing SREBP-1a under the control of the PEPCK promoter exhibit insulin resistance, but not diabetes.
Marek Disease
Mitochondrial PEPCK: a highly polymorphic gene with alleles co-selected with Marek's disease resistance in chickens.
Mycoses
Protection of wheat against leaf and stem rust and powdery mildew diseases by inhibition of polyamine metabolism.
Neoplasms
Arginine and nutrition in renal disease.
Gluconeogenesis in Cancer: Function and Regulation of PEPCK, FBPase, and G6Pase.
PEPCK Coordinates the Regulation of Central Carbon Metabolism to Promote Cancer Cell Growth.
PEPCK in cancer cell starvation.
Obesity
Increased fatty acid re-esterification by PEPCK overexpression in adipose tissue leads to obesity without insulin resistance.
phosphoenolpyruvate carboxylase deficiency
Three rare diseases in one Sib pair: RAI1, PCK1, GRIN2B mutations associated with Smith-Magenis Syndrome, cytosolic PEPCK deficiency and NMDA receptor glutamate insensitivity.
Potassium Deficiency
Regulation of Arabidopsis thaliana (L.) Heynh Arginine decarboxylase by potassium deficiency stress.
Seizures
Anticonvulsive effect of agmatine in mice.
Smith-Magenis Syndrome
Three rare diseases in one Sib pair: RAI1, PCK1, GRIN2B mutations associated with Smith-Magenis Syndrome, cytosolic PEPCK deficiency and NMDA receptor glutamate insensitivity.
Spinal Cord Injuries
Restorative benefits of transplanting human mesenchymal stromal cells overexpressing arginine decarboxylase genes after spinal cord injury.
Starvation
Mechanisms by which liver-specific PEPCK knockout mice preserve euglycemia during starvation.
On the mechanism of gluconeogenesis and its regulation. 3. The glucogenic capacity and the activities of pyruvate carboxylase and PEP-carboxylase of rat kidney and rat liver after cortisol treatment and starvation.
PEPCK in cancer cell starvation.
Two isoforms of Pepck in Sarcophaga bullata and their distinct expression profiles through development, diapause, and in response to stresses of cold and starvation.
Trauma, Nervous System
The multifaceted effects of agmatine on functional recovery after spinal cord injury through Modulations of BMP-2/4/7 expressions in neurons and glial cells.