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Information on EC 4.1.1.19 - arginine decarboxylase and Organism(s) Pseudomonas aeruginosa and UniProt Accession Q9HUX1

for references in articles please use BRENDA:EC4.1.1.19
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EC Tree
     4 Lyases
         4.1 Carbon-carbon lyases
             4.1.1 Carboxy-lyases
                4.1.1.19 arginine decarboxylase
IUBMB Comments
A pyridoxal-phosphate protein.
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Select one or more organisms in this record: ?
This record set is specific for:
Pseudomonas aeruginosa
UNIPROT: Q9HUX1
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The taxonomic range for the selected organisms is: Pseudomonas aeruginosa
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Reaction Schemes
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L-arginine
=
agmatine
+
CO2
=
+
Synonyms
arginine decarboxylase, spea2, argdc, spea1, biosynthetic arginine decarboxylase, ppadc, pyruvoyl-dependent arginine decarboxylase, atadc2, l-arginine decarboxylase, ptadc, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
ARGDC
-
-
-
-
bADC
-
-
-
-
Biosynthetic arginine decarboxylase
-
-
-
-
dADC
-
-
-
-
Decarboxylase, arginine
-
-
-
-
L-Arginine decarboxylase
-
-
-
-
Synthetic arginine decarboxylase
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
decarboxylation
-
-
-
-
PATHWAY SOURCE
PATHWAYS
-
-, -, -, -, -, -
SYSTEMATIC NAME
IUBMB Comments
L-arginine carboxy-lyase (agmatine-forming)
A pyridoxal-phosphate protein.
CAS REGISTRY NUMBER
COMMENTARY hide
9024-77-5
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
L-arginine
agmatine + CO2
show the reaction diagram
-
-
-
?
L-arginine
agmatine + CO2
show the reaction diagram
-
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
L-arginine
agmatine + CO2
show the reaction diagram
-
-
-
?
L-arginine
agmatine + CO2
show the reaction diagram
-
-
-
?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
pyridoxal 5'-phosphate
-
pyridoxal 5'-phosphate
-
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
in bacteria agmatine serves as a precursor to polyamine synthesis and enhances biofilm development in some strains of the respiratory pathogen Pseudomonas aeruginosa. Agmatine is at the center of a competing metabolism in the human lung during airways infections and is influenced by the metabolic phenotypes of the infecting pathogens, e.g. Pseudomonas aeruginosa. The agu2ABCA' operon in Pseudomonas aeruginosa has a mechanism to detect extracellular agmatine and react by augmenting its biofilm. Pseudomonas aeruginosa encounters agmatine in lung infections, and this triggers planktonic pseudomonads to form a biofilm
additional information
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
x * 70600, about, recombinant His6-tagged enzyme, sequence calculation
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
80
purified recombinant enzyme, pH 8.4, 10 min, inactivation
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
recombinant His6-tagged enzyme from Escherichia coli strain SM10 by nickel affinity chromatography
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
gene speA, recombinant expression of His6-tagged enzyme in Escherichia coli strain SM10
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Dalluge, J.J.; McCurtain, J.L.; Gilbertsen, A.J.; Kalstabakken, K.A.; Williams, B.J.
Determination of agmatine using isotope dilution UPLC-tandem mass spectrometry application to the characterization of the arginine decarboxylase pathway in Pseudomonas aeruginosa
Anal. Bioanal. Chem.
407
5513-5519
2015
Pseudomonas aeruginosa (A0A0H2ZHZ8), Pseudomonas aeruginosa, Pseudomonas aeruginosa UCBPP-PA14 (A0A0H2ZHZ8)
Manually annotated by BRENDA team
Paulson, N.B.; Gilbertsen, A.J.; Dalluge, J.J.; Welchlin, C.W.; Hughes, J.; Han, W.; Blackwell, T.S.; Laguna, T.A.; Williams, B.J.
The arginine decarboxylase pathways of host and pathogen interact to impact inflammatory pathways in the lung
PLoS ONE
9
e111441
2014
Homo sapiens, Mus musculus, Pseudomonas aeruginosa (Q9HUX1), Pseudomonas aeruginosa, Pseudomonas aeruginosa ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1 (Q9HUX1)
Manually annotated by BRENDA team