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The enzyme participates in an alternative mevalonate pathway that takes place in extreme acidophiles of the Thermoplasmatales order. cf. EC 188.8.131.52, phosphomevalonate decarboxylase.
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The enzyme appears in viruses and cellular organisms
(R)-mevalonate 3,5-bisphosphate decarboxylase, MBD, mevalonate 3,5-bisphosphate decarboxylase, Mevalonate pyrophosphate decarboxylase, more
(R)-3,5-bisphosphomevalonate = isopentenyl phosphate + CO2 + phosphate
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