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EC Tree
IUBMB Comments The enzyme participates in an alternative mevalonate pathway that takes place in extreme acidophiles of the Thermoplasmatales order. cf. EC 4.1.1.99, phosphomevalonate decarboxylase.
The enzyme appears in viruses and cellular organisms
Synonyms
(R)-mevalonate 3,5-bisphosphate decarboxylase, MBD, mevalonate 3,5-bisphosphate decarboxylase, Mevalonate pyrophosphate decarboxylase,
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(R)-mevalonate 3,5-bisphosphate decarboxylase
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mevalonate 3,5-bisphosphate decarboxylase
Mevalonate pyrophosphate decarboxylase
MBD
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mevalonate 3,5-bisphosphate decarboxylase
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mevalonate 3,5-bisphosphate decarboxylase
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mevalonate 3,5-bisphosphate decarboxylase
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mevalonate 3,5-bisphosphate decarboxylase
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Mevalonate pyrophosphate decarboxylase
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Mevalonate pyrophosphate decarboxylase
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Mevalonate pyrophosphate decarboxylase
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(R)-3,5-bisphosphomevalonate = isopentenyl phosphate + CO2 + phosphate
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(R)-3,5-bisphosphomevalonate carboxy-lyase (isopentenyl-phosphate-forming)
The enzyme participates in an alternative mevalonate pathway that takes place in extreme acidophiles of the Thermoplasmatales order. cf. EC 4.1.1.99, phosphomevalonate decarboxylase.
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(R)-3,5-bisphosphomevalonate
isopentenyl phosphate + CO2 + phosphate
(R)-3,5-bisphosphomevalonate
isopentenyl phosphate + CO2 + phosphate
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(R)-3,5-bisphosphomevalonate
isopentenyl phosphate + CO2 + phosphate
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?
(R)-3,5-bisphosphomevalonate
isopentenyl phosphate + CO2 + phosphate
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?
(R)-3,5-bisphosphomevalonate
isopentenyl phosphate + CO2 + phosphate
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-
?
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(R)-3,5-bisphosphomevalonate
isopentenyl phosphate + CO2 + phosphate
(R)-3,5-bisphosphomevalonate
isopentenyl phosphate + CO2 + phosphate
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-
?
(R)-3,5-bisphosphomevalonate
isopentenyl phosphate + CO2 + phosphate
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-
?
(R)-3,5-bisphosphomevalonate
isopentenyl phosphate + CO2 + phosphate
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-
-
?
(R)-3,5-bisphosphomevalonate
isopentenyl phosphate + CO2 + phosphate
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-
-
?
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UniProt
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UniProt
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UniProt
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MBD_PICTO
Picrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828)
349
0
40022
Swiss-Prot
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MBD_THEAC
Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
405
0
46288
Swiss-Prot
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MBD_THEVO
Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)
372
0
42524
Swiss-Prot
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homodimer
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2 * 46300, calculated from amino acid sequence
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Ni-NTA column chromatography
Ni-NTA column chromatography
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Ni-NTA column chromatography
Ni-NTA column chromatography
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expressed in Escherichia coli BL21(DE3) cells
expressed in Escherichia coli BL21(DE3) cells
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expressed in Escherichia coli BL21(DE3) cells
expressed in Escherichia coli BL21(DE3) cells
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Azami, Y.; Hattori, A.; Nishimura, H.; Kawaide, H.; Yoshimura, T.; Hemmi, H.
(R)-mevalonate 3-phosphate is an intermediate of the mevalonate pathway in Thermoplasma acidophilum
J. Biol. Chem.
289
15957-15967
2014
Thermoplasma acidophilum (Q9HJS1), Thermoplasma acidophilum
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Vinokur, J.M.; Cummins, M.C.; Korman, T.P.; Bowie, J.U.
An adaptation to life in acid through a novel mevalonate pathway
Sci. Rep.
6
39737
2016
Thermoplasma acidophilum, Picrophilus torridus (Q6L1T9), Thermoplasma volcanium (Q97BM8)
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