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Information on EC 4.1.1.1 - pyruvate decarboxylase and Organism(s) Arabidopsis thaliana and UniProt Accession O82647

for references in articles please use BRENDA:EC4.1.1.1
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EC Tree
     4 Lyases
         4.1 Carbon-carbon lyases
             4.1.1 Carboxy-lyases
                4.1.1.1 pyruvate decarboxylase
IUBMB Comments
A thiamine-diphosphate protein. Also catalyses acyloin formation.
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Select one or more organisms in this record: ?
This record set is specific for:
Arabidopsis thaliana
UNIPROT: O82647
Word Map
The taxonomic range for the selected organisms is: Arabidopsis thaliana
The enzyme appears in selected viruses and cellular organisms
Synonyms
pdc, pyruvate decarboxylase, acetohydroxyacid synthase, yeast pyruvate decarboxylase, pdc1p, ifpl730, p59nc, zmpdc, pyruvate decarboxylase 1, pdc5p, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
8-10 nm cytoplasmic filament-associated protein
-
-
-
0
alpha-Carboxylase
-
-
-
0
alpha-Keto acid carboxylase
-
-
-
0
Decarboxylase, pyruvate
-
-
-
0
P59NC
-
-
-
0
PDC1
302
isoform
Pyruvic decarboxylase
-
-
-
0
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
decarboxylation
-
-
-
0
SYSTEMATIC NAME
IUBMB Comments
2-oxo-acid carboxy-lyase (aldehyde-forming)
A thiamine-diphosphate protein. Also catalyses acyloin formation.
CAS REGISTRY NUMBER
COMMENTARY hide
9001-04-1
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
pyruvate
acetaldehyde + CO2
show the reaction diagram
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
pyruvate
acetaldehyde + CO2
show the reaction diagram
ethanol fermentation pathway, involved in anaerobic metabolism
-
?
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
isozyme PDC1; four genes encoding PDC isozymes
UniProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
PDC1 is predominantly present in roots
Manually annotated by BRENDA team
isoform PDC1 is predominantly present in roots
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
mutations in both PDC1 and PDC2 result in lower tolerance to submergence
metabolism
activities of pyruvate decarboxylase and alcohol dehydrogenase are required for the fermentative pathway, with ethanol as the predominant end product. Not only isozyme PDC1 but also isozyme PDC2 play a role under hypoxic conditions. The enzyme has a role under aerobic conditions, which is not coupled to fermentative metabolism
physiological function
isozymes PDC1 and PDC2 are involved in low-oxygen responses, whereas isozymes PDC3 and PDC4 are not affected by hypoxia/anoxia conditions
malfunction
mutations in both PDC1 and PDC2 result in lower tolerance to submergence
metabolism
physiological function
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
PDC1_ARATH
607
0
66212
Swiss-Prot
other Location (Reliability: 2)
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
PDC2 gene, overexpression improves the tolerance of hairy roots to low oxygen conditions
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
expression of both PDC1 and PDC2 is strongly upregulated under low oxygen
expression of both PDC1 and PDC2 is strongly upregulated under low oxygen
gene PDC3 is not regulated by low-oxygen stress
gene PDC4 is not regulated by low-oxygen stress
the expression of both isoforms PDC1 and PDC2 is strongly up-regulated under low oxygen
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Shiao, T.L.; Ellis, M.H.; Dolferus, R.; Dennis, E.S.; Doran, P.M.
Overexpression of alcohol dehydrogenase or pyruvate decarboxylase improves growth of hairy roots at reduced oxygen concentrations
Biotechnol. Bioeng.
77
455-461
2002
Arabidopsis thaliana (Q9FFT4), Arabidopsis thaliana
Manually annotated by BRENDA team
Mithran, M.; Paparelli, E.; Novi, G.; Perata, P.; Loreti, E.
Analysis of the role of the pyruvate decarboxylase gene family in Arabidopsis thaliana under low-oxygen conditions
Plant Biol.
16
28-34
2013
Arabidopsis thaliana, Arabidopsis thaliana (O82647), Arabidopsis thaliana (Q9FFT4), Arabidopsis thaliana (Q9M039), Arabidopsis thaliana (Q9M040), Arabidopsis thaliana Col-0 (O82647), Arabidopsis thaliana Col-0 (Q9FFT4), Arabidopsis thaliana Col-0 (Q9M039), Arabidopsis thaliana Col-0 (Q9M040)
Manually annotated by BRENDA team
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