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4-nitrophenylphosphate + H2O
4-nitrophenol + phosphate
-
-
-
?
6,8-difluoromethylumbelliferyl phosphate + H2O
6,8-difluoromethylumbelliferone + phosphate
-
-
-
?
a [protein]-N-phospho-L-histidine + H2O
a [protein]-L-histidine + phosphate
AKR-N-phospho-HKV + H2O
AKRHKV + phosphate
-
-
-
-
?
succinyl-L-Ala-N-phospho-L-His-L-Pro-L-Phe 4-nitroanilide + H2O
succinyl-L-Ala-L-His-L-Pro-L-Phe 4-nitroanilide + phosphate
VIFIE-N-phospho-HAKRKG + H2O
VIFIEHAKRKG + phosphate
-
-
-
-
?
[ATP-citrate lyase]-N-phospho-L-histidine + H2O
[ATP-citrate lyase]-L-histidine + phosphate
[KCa3.1 channel protein]-N-phospho-L-histidine + H2O
[KCa3.1 channel protein]-L-histidine + phosphate
-
the enzyme directly binds and inhibits KCa3.1 by dephosphorylating histidine 358
-
-
?
[peptide]-N-phospho-L-histidine + H2O
[peptide]-L-histidine + phosphate
H2O2 exposure induces selective oxidation of hPHPT1 at Met95, a residue within the substrate binding region. H2O2-induced oxidation does not impact hPHPT1 function negatively
-
-
?
[protein]-N-phospho-L-histidine + H2O
[protein]-L-histidine + phosphate
-
-
-
-
?
additional information
?
-
a [protein]-N-phospho-L-histidine + H2O
a [protein]-L-histidine + phosphate
-
-
-
-
?
a [protein]-N-phospho-L-histidine + H2O
a [protein]-L-histidine + phosphate
-
-
-
?
a [protein]-N-phospho-L-histidine + H2O
a [protein]-L-histidine + phosphate
-
-
-
-
?
a [protein]-N-phospho-L-histidine + H2O
a [protein]-L-histidine + phosphate
-
-
-
?
a [protein]-N-phospho-L-histidine + H2O
a [protein]-L-histidine + phosphate
-
-
-
-
?
succinyl-L-Ala-N-phospho-L-His-L-Pro-L-Phe 4-nitroanilide + H2O
succinyl-L-Ala-L-His-L-Pro-L-Phe 4-nitroanilide + phosphate
-
-
-
?
succinyl-L-Ala-N-phospho-L-His-L-Pro-L-Phe 4-nitroanilide + H2O
succinyl-L-Ala-L-His-L-Pro-L-Phe 4-nitroanilide + phosphate
-
-
-
-
?
[ATP-citrate lyase]-N-phospho-L-histidine + H2O
[ATP-citrate lyase]-L-histidine + phosphate
-
-
-
-
?
[ATP-citrate lyase]-N-phospho-L-histidine + H2O
[ATP-citrate lyase]-L-histidine + phosphate
-
-
-
?
additional information
?
-
-
the enzyme also dephosphorylates phospholysine of chemically phosphorylated histone H1.2 and polylysine
-
-
?
additional information
?
-
-
the enzyme does not dephosphorylate free phosphoarginine
-
-
?
additional information
?
-
-
the enzyme is unable to catalyse the dephosphorylation of histone H4 that has been phosphorylated with a histone H4 histidine kinase
-
-
?
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a [protein]-N-phospho-L-histidine + H2O
a [protein]-L-histidine + phosphate
[ATP-citrate lyase]-N-phospho-L-histidine + H2O
[ATP-citrate lyase]-L-histidine + phosphate
[KCa3.1 channel protein]-N-phospho-L-histidine + H2O
[KCa3.1 channel protein]-L-histidine + phosphate
-
the enzyme directly binds and inhibits KCa3.1 by dephosphorylating histidine 358
-
-
?
[protein]-N-phospho-L-histidine + H2O
[protein]-L-histidine + phosphate
-
-
-
-
?
additional information
?
-
a [protein]-N-phospho-L-histidine + H2O
a [protein]-L-histidine + phosphate
-
-
-
-
?
a [protein]-N-phospho-L-histidine + H2O
a [protein]-L-histidine + phosphate
-
-
-
?
a [protein]-N-phospho-L-histidine + H2O
a [protein]-L-histidine + phosphate
-
-
-
-
?
a [protein]-N-phospho-L-histidine + H2O
a [protein]-L-histidine + phosphate
-
-
-
?
a [protein]-N-phospho-L-histidine + H2O
a [protein]-L-histidine + phosphate
-
-
-
-
?
[ATP-citrate lyase]-N-phospho-L-histidine + H2O
[ATP-citrate lyase]-L-histidine + phosphate
-
-
-
-
?
[ATP-citrate lyase]-N-phospho-L-histidine + H2O
[ATP-citrate lyase]-L-histidine + phosphate
-
-
-
?
additional information
?
-
-
the enzyme also dephosphorylates phospholysine of chemically phosphorylated histone H1.2 and polylysine
-
-
?
additional information
?
-
-
the enzyme does not dephosphorylate free phosphoarginine
-
-
?
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Atherosclerosis
Nucleoside diphosphate kinase B-activated intermediate conductance potassium channels are critical for neointima formation in mouse carotid arteries.
Carcinogenesis
Knockdown of 14-kDa phosphohistidine phosphatase expression suppresses lung cancer cell growth in vivo possibly through inhibition of NF-?B signaling pathway.
Carcinoma
Nuclear expression and clinical significance of phosphohistidine phosphatase 1 in clear-cell renal cell carcinoma.
Carcinoma, Hepatocellular
14-kDa Phosphohistidine phosphatase plays an important role in hepatocellular carcinoma cell proliferation.
Carcinoma, Hepatocellular
LHPP suppresses proliferation, migration, and invasion and promotes apoptosis in pancreatic cancer.
Carcinoma, Renal Cell
Nuclear expression and clinical significance of phosphohistidine phosphatase 1 in clear-cell renal cell carcinoma.
Colorectal Neoplasms
Differential expression of alternatively spliced transcripts related to energy metabolism in colorectal cancer.
Infections
Primary hyperparathyroidism characterized by diffuse homogeneous metastatic pulmonary calcification: A case report.
Liver Cirrhosis
14-kDa phosphohistidine phosphatase is a potential therapeutic target for liver fibrosis.
Liver Cirrhosis
PHP14 regulates hepatic stellate cells migration in liver fibrosis via mediating TGF-?1 signaling to PI3K?/AKT/Rac1 pathway.
Lung Neoplasms
14-kDa phosphohistidine phosphatase and its role in human lung cancer cell migration and invasion.
Lung Neoplasms
14-kDa Phosphohistidine phosphatase plays an important role in hepatocellular carcinoma cell proliferation.
Lung Neoplasms
Clinical significance of PHPT1 protein expression in lung cancer.
Lung Neoplasms
Knockdown of 14-kDa phosphohistidine phosphatase expression suppresses lung cancer cell growth in vivo possibly through inhibition of NF-?B signaling pathway.
Lymphatic Metastasis
Clinical significance of PHPT1 protein expression in lung cancer.
Neoplasm Metastasis
14-kDa phosphohistidine phosphatase and its role in human lung cancer cell migration and invasion.
Neoplasm Metastasis
Clinical significance of PHPT1 protein expression in lung cancer.
Neoplasms
14-kDa Phosphohistidine phosphatase plays an important role in hepatocellular carcinoma cell proliferation.
Neoplasms
Down-regulation of LHPP in cervical cancer influences cell proliferation, metastasis and apoptosis by modulating AKT.
Neoplasms
Immunohistochemistry (IHC): Chromogenic Detection of 3-Phosphohistidine Proteins in Formaldehyde-Fixed, Frozen Mouse Liver Tissue Sections.
Neoplasms
Knockdown of 14-kDa phosphohistidine phosphatase expression suppresses lung cancer cell growth in vivo possibly through inhibition of NF-?B signaling pathway.
Neoplasms
LHPP suppresses proliferation, migration, and invasion and promotes apoptosis in pancreatic cancer.
Neoplasms
Nuclear expression and clinical significance of phosphohistidine phosphatase 1 in clear-cell renal cell carcinoma.
Neoplasms
Specific Fluorescent Probe for Protein Histidine Phosphatase Activity.
Neoplasms
The protein histidine phosphatase LHPP is a tumour suppressor.
Respiratory Tract Infections
Primary hyperparathyroidism characterized by diffuse homogeneous metastatic pulmonary calcification: A case report.
Urinary Bladder Neoplasms
LHPP suppresses proliferation, migration, and invasion and promotes apoptosis in pancreatic cancer.
Uterine Cervical Neoplasms
LHPP suppresses proliferation, migration, and invasion and promotes apoptosis in pancreatic cancer.
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metabolism
LHPP is a protein histidine phosphatase and tumour suppressor, suggesting that deregulated histidine phosphorylation is oncogenic
malfunction
-
cell proliferation is inhibited and cell apoptosis is significantly increased following knockdown of 14kDa phosphohistidine phosphatase
malfunction
-
decreased expression of PHPT-1 in human CD4 T cells results in an increase in KCa3.1 channel activity and increases Ca2+ influx and proliferation after T cell receptor activation
malfunction
enzyme knockdown in highly metastatic lung cancer CL1-5 cells inhibits migration and invasion in vitro, but does not alter cell proliferation rates, while enzyme overexpression in H1299 cells promotes migration and invasion in vitro, but again does not alter cell proliferation
malfunction
PHP14 knockdown impairs Arp3 localization at the leading edge of lamellipodia, as well as lamellipodia formation
metabolism
-
the enzyme reduces the activity of ATP-citrate lyase by dephosphorylation at His760 in the active site and, thus controls the main intermediate metabolism of the cell
metabolism
PHP14 promotes hepatic stellate cell migration, especially, promotes 3D floating collagen matrices contraction but inhibits stress released matrices contraction. Mechanistically, the PI3Kgamma/AKT/Rac1 pathway is involved in migration regulated by PHP14. Moreover, PHP14 specifically mediates the TGF-beta1 signaling to PI3Kgamma/AKT pathway and regulates HSC migration, and thus participates in liver fibrosis
physiological function
enzyme overexpression induces apoptosis in umbilical-vein endothelial cells
physiological function
-
the endogenous enzyme negatively regulates CD4 T cells
physiological function
the enzyme is involved in cytoskeletal reorganization and therfore is functionally important in lung cancer cell migration and the invasion of lung cancer cells, mediated partly through modulation of actin cytoskeleton rearrangement
physiological function
role for PHP14 in the dynamic regulation of the actin cytoskeleton and cell migration
physiological function
the enzyme (PHP14) regulates hepatic stellate cells migration in liver fibrosis via mediating TGF-beta1 signaling to PI3Kgamma/AKT/Rac1 pathway
additional information
H2O2 exposure induces selective oxidation of hPHPT1 at Met95, a residue within the substrate binding region. H2O2-induced oxidation does not impact hPHPT1 function negatively
additional information
-
H2O2 exposure induces selective oxidation of hPHPT1 at Met95, a residue within the substrate binding region. H2O2-induced oxidation does not impact hPHPT1 function negatively
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Ma, R.; Kanders, E.; Sundh, U.B.; Geng, M.; Ek, P.; Zetterqvist, O.; Li, J.P.
Mutational study of human phosphohistidine phosphatase: effect on enzymatic activity
Biochem. Biophys. Res. Commun.
337
887-891
2005
Homo sapiens (Q9NRX4), Homo sapiens
brenda
Gong, W.; Li, Y.; Cui, G.; Hu, J.; Fang, H.; Jin, C.; Xia, B.
Solution structure and catalytic mechanism of human protein histidine phosphatase 1
Biochem. J.
418
337-344
2009
Homo sapiens (Q9NRX4), Homo sapiens
brenda
Attwood, P.V.; Ludwig, K.; Bergander, K.; Besant, P.G.; Adina-Zada, A.; Krieglstein, J.; Klumpp, S.
Chemical phosphorylation of histidine-containing peptides based on the sequence of histone H4 and their dephosphorylation by protein histidine phosphatase
Biochim. Biophys. Acta
1804
199-205
2010
Homo sapiens
brenda
Klumpp, S.; Ma, N.T.; Baeumer, N.; Bechmann, G.; Krieglstein, J.
Relevance of glycine and cysteine residues as well as N- and C-terminals for the activity of protein histidine phosphatase
Biochim. Biophys. Acta
1804
206-211
2010
Homo sapiens
brenda
Klumpp, S.; Faber, D.; Fischer, D.; Litterscheid, S.; Krieglstein, J.
Role of protein histidine phosphatase for viability of neuronal cells
Brain Res.
1264
7-12
2009
Homo sapiens
brenda
Seeger, A.; Rose, K.; Ma, N.T.; Kremmer, E.; Klumpp, S.; Krieglstein, J.
Influence of protein histidine phosphatase overexpression and down-regulation on human umbilical-vein endothelial cell viability
Cell Biol. Int.
36
245-249
2012
Homo sapiens (Q9NRX4), Homo sapiens
brenda
Ek, P.; Pettersson, G.; Ek, B.; Gong, F.; Li, J.P.; Zetterqvist, O.
Identification and characterization of a mammalian 14-kDa phosphohistidine phosphatase
Eur. J. Biochem.
269
5016-5023
2002
Homo sapiens (Q9NRX4), Homo sapiens, Sus scrofa
brenda
Busam, R.D.; Thorsell, A.G.; Flores, A.; Hammarstroem, M.; Persson, C.; Hallberg, B.M.
First structure of a eukaryotic phosphohistidine phosphatase
J. Biol. Chem.
281
33830-33834
2006
Homo sapiens (Q9NRX4)
brenda
Shen, H.; Yang, P.; Liu, Q.; Tian, Y.
Nuclear expression and clinical significance of phosphohistidine phosphatase 1 in clear-cell renal cell carcinoma
J. Int. Med. Res.
43
747-757
2015
Homo sapiens
brenda
Xu, A.; Hao, J.; Zhang, Z.; Tian, T.; Jiang, S.; Hao, J.; Liu, C.; Huang, L.; Xiao, X.; He, D.
14-kDa phosphohistidine phosphatase and its role in human lung cancer cell migration and invasion
Lung Cancer
67
48-56
2010
Homo sapiens (Q9NRX4), Homo sapiens
brenda
Han, S.X.; Wang, L.J.; Zhao, J.; Zhang, Y.; Li, M.; Zhou, X.; Wang, J.; Zhu, Q.
14-kDa phosphohistidine phosphatase plays an important role in hepatocellular carcinoma cell proliferation
Oncol. Lett.
4
658-664
2012
Homo sapiens
brenda
Ludwig, K.; Habbach, S.; Krieglstein, J.; Klumpp, S.; Koenig, S.
MALDI-TOF high mass calibration up to 200 kDa using human recombinant 16 kDa protein histidine phosphatase aggregates
PLoS ONE
6
e23612
2011
Homo sapiens
brenda
Srivastava, S.; Zhdanova, O.; Di, L.; Li, Z.; Albaqumi, M.; Wulff, H.; Skolnik, E.Y.
Protein histidine phosphatase 1 negatively regulates CD4 T cells by inhibiting the K+ channel KCa3.1
Proc. Natl. Acad. Sci. USA
105
14442-14446
2008
Homo sapiens
brenda
Ek, P.; Ek, B.; Zetterqvist, O.e.
Phosphohistidine phosphatase 1 (PHPT1) also dephosphorylates phospholysine of chemically phosphorylated histone H1 and polylysine
Ups. J. Med. Sci.
120
20-27
2015
Homo sapiens
brenda
McCullough, B.S.; Barrios, A.M.
Facile, fluorogenic assay for protein histidine phosphatase activity
Biochemistry
57
2584-2589
2018
Homo sapiens (Q9NRX4)
brenda
Xu, A.; Li, X.; Li, S.; Sun, L.; Wu, S.; Zhang, B.; Huang, J.
A novel role for 14-kDa phosphohistidine phosphatase in lamellipodia formation
Cell Adh. Migr.
11
488-495
2017
Homo sapiens (Q9NRX4)
brenda
Xu, A.; Li, Y.; Zhao, W.; Hou, F.; Li, X.; Sun, L.; Chen, W.; Yang, A.; Wu, S.; Zhang, B.; Yao, J.; Wang, H.; Huang, J.
PHP14 regulates hepatic stellate cells migration in liver fibrosis via mediating TGF-beta1 signaling to PI3Kgama/AKT/Rac1 pathway
J. Mol. Med.
96
119-133
2018
Homo sapiens (Q9NRX4)
brenda
Hindupur, S.K.; Colombi, M.; Fuhs, S.R.; Matter, M.S.; Guri, Y.; Adam, K.; Cornu, M.; Piscuoglio, S.; Ng, C.K.Y.; Betz, C.; Liko, D.; Quagliata, L.; Moes, S.; Jenoe, P.; Terracciano, L.M.; Heim, M.H.; Hunter, T.; Hall, M.N.
The protein histidine phosphatase LHPP is a tumour suppressor
Nature
555
678-682
2018
Homo sapiens (Q9H008), Homo sapiens, Mus musculus (Q9D7I5), Mus musculus
brenda
Martin, D.R.; Dutta, P.; Mahajan, S.; Varma, S.; Stevens, S.M.
Structural and activity characterization of human PHPT1 after oxidative modification
Sci. Rep.
6
23658
2016
Homo sapiens (Q9NRX4), Homo sapiens
brenda