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1-haloalkane + H2O = a primary alcohol + halide
1-haloalkane + H2O = a primary alcohol + halide

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1-haloalkane + H2O = a primary alcohol + halide
catalytic mechanism
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1-haloalkane + H2O = a primary alcohol + halide
GJ10, three-step reaction mechanism with covalent alkyl-enzyme ester intermediate
1-haloalkane + H2O = a primary alcohol + halide
GJ10, four-step reaction mechanism with covalent ester intermediate
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1-haloalkane + H2O = a primary alcohol + halide
distinction of 3 different substrate classes for haloalkane dehalogenases after profound statistical reaction rate analysis
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1-haloalkane + H2O = a primary alcohol + halide
distinction of 3 different substrate classes for haloalkane dehalogenases after profound statistical reaction rate analysis
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1-haloalkane + H2O = a primary alcohol + halide
distinction of 3 different substrate classes for haloalkane dehalogenases after profound statistical reaction rate analysis
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1-haloalkane + H2O = a primary alcohol + halide
distinction of 3 different substrate classes for haloalkane dehalogenases after profound statistical reaction rate analysis
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1-haloalkane + H2O = a primary alcohol + halide
alpha/beta hydrolase with catalytic triad, i.e. nucleophile (Asp124)-histidine (H289)-acid (Asp260), during catalytic reaction
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1-haloalkane + H2O = a primary alcohol + halide
alpha/beta hydrolase with catalytic triad, i.e. nucleophile (Asp124)-histidine (H289)-acid (Asp260), during catalytic reaction
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1-haloalkane + H2O = a primary alcohol + halide
alpha/beta hydrolase with catalytic triad, i.e. nucleophile (Asp124)-histidine (H289)-acid (Asp260), during catalytic reaction
1-haloalkane + H2O = a primary alcohol + halide
GJ10, detailed reaction mechanism and energetics calculated from computational model
1-haloalkane + H2O = a primary alcohol + halide
two-step mechanism involving an ester intermediate covalently bound at Asp124, His 289 is important for hydrolysis
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1-haloalkane + H2O = a primary alcohol + halide
3 features are important for catalytic performance: i. a catalytic triad, ii. anoxyanion hole, and iii. the halide-stabilizing residues, which are not conserved among different haloalkane dehalogenases, active site structure, Asn38 is involved, SN2 reaction mechanism, modeling, overview
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1-haloalkane + H2O = a primary alcohol + halide
3 features are important for catalytic performance: i. a catalytic triad, ii. anoxyanion hole, and iii. the halide-stabilizing residues, which are not conserved among different haloalkane dehalogenases, active site structure, Asn41 is involved, SN2 reaction mechanism, modeling, overview
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1-haloalkane + H2O = a primary alcohol + halide
3 features are important for catalytic performance: i. a catalytic triad, ii. anoxyanion hole, and iii. the halide-stabilizing residues, which are not conserved among different haloalkane dehalogenases, active site structure, Glu56 is involved, SN2 reaction mechanism, modeling, overview
1-haloalkane + H2O = a primary alcohol + halide
acts on a wide range of 1-haloalkanes, haloalcohols, haloalkenes and some haloaromatic compounds
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1-haloalkane + H2O = a primary alcohol + halide
catalytic nucleophile Asp108, which is the most disordered catalytic residue, catalytic base His272, structure-based reaction mechanism, active site structure, overview
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1-haloalkane + H2O = a primary alcohol + halide
low activity with small, chlorinated alkanes, importance of active site water molecules and reaction products in molecular docking
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1-haloalkane + H2O = a primary alcohol + halide
substrate specificity is influenced by the size and shape of their entrance tunnel, surface residue Leu177 is involved and located at the tunnel opening
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1-haloalkane + H2O = a primary alcohol + halide
activation energy of reaction 59.5 kJ/mol
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1-haloalkane + H2O = a primary alcohol + halide
catalytic triad consists of D123, H279, D250, with a first halide-stabilizing W124 and a secong stabilizing residue W164. Two-step reaction mechanism
1-haloalkane + H2O = a primary alcohol + halide
H272 singly protonated at Ndelta1 and D108 in conformation A give the most exothermic reactionwith DeltaH of -22 kcal/mol
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1-haloalkane + H2O = a primary alcohol + halide
hydrogen bond interactions between substrate and the environment are significantly different in aqueous solution and in the enzyme. Structure of the enzyme active site provides a more adequate interaction pattern for the reaction process
1-haloalkane + H2O = a primary alcohol + halide
Asp103, Glu127 and His280 are involved in the catalytic reaction, and two H-bond donating residues, Asn38 and Trp104, are involved in stabilization of a halogen group of the substrate
1-haloalkane + H2O = a primary alcohol + halide
reaction mechanism, overview. The bromide release is the rate-limiting step of the catalytic cycle, overview
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1-haloalkane + H2O = a primary alcohol + halide
structural basis for its reaction mechanism
1-haloalkane + H2O = a primary alcohol + halide
Asp103, Glu127 and His280 are involved in the catalytic reaction, and two H-bond donating residues, Asn38 and Trp104, are involved in stabilization of a halogen group of the substrate
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1-haloalkane + H2O = a primary alcohol + halide
catalytic nucleophile Asp108, which is the most disordered catalytic residue, catalytic base His272, structure-based reaction mechanism, active site structure, overview
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1-haloalkane + H2O = a primary alcohol + halide
H272 singly protonated at Ndelta1 and D108 in conformation A give the most exothermic reactionwith DeltaH of -22 kcal/mol
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1-haloalkane + H2O = a primary alcohol + halide
alpha/beta hydrolase with catalytic triad, i.e. nucleophile (Asp124)-histidine (H289)-acid (Asp260), during catalytic reaction
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1-haloalkane + H2O = a primary alcohol + halide
3 features are important for catalytic performance: i. a catalytic triad, ii. anoxyanion hole, and iii. the halide-stabilizing residues, which are not conserved among different haloalkane dehalogenases, active site structure, Asn38 is involved, SN2 reaction mechanism, modeling, overview
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1-haloalkane + H2O = a primary alcohol + halide
low activity with small, chlorinated alkanes, importance of active site water molecules and reaction products in molecular docking
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1-haloalkane + H2O = a primary alcohol + halide
substrate specificity is influenced by the size and shape of their entrance tunnel, surface residue Leu177 is involved and located at the tunnel opening
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1-haloalkane + H2O = a primary alcohol + halide
catalytic triad consists of D123, H279, D250, with a first halide-stabilizing W124 and a secong stabilizing residue W164. Two-step reaction mechanism
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1-haloalkane + H2O = a primary alcohol + halide
distinction of 3 different substrate classes for haloalkane dehalogenases after profound statistical reaction rate analysis
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1-haloalkane + H2O = a primary alcohol + halide
structural basis for its reaction mechanism
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1-haloalkane + H2O = a primary alcohol + halide
distinction of 3 different substrate classes for haloalkane dehalogenases after profound statistical reaction rate analysis
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1-haloalkane + H2O = a primary alcohol + halide
two-step mechanism involving an ester intermediate covalently bound at Asp124, His 289 is important for hydrolysis
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1-haloalkane + H2O = a primary alcohol + halide
GJ10, four-step reaction mechanism with covalent ester intermediate
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1-haloalkane + H2O = a primary alcohol + halide
alpha/beta hydrolase with catalytic triad, i.e. nucleophile (Asp124)-histidine (H289)-acid (Asp260), during catalytic reaction
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1-haloalkane + H2O = a primary alcohol + halide
GJ10, three-step reaction mechanism with covalent alkyl-enzyme ester intermediate
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1-haloalkane + H2O = a primary alcohol + halide
GJ10, detailed reaction mechanism and energetics calculated from computational model
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1-haloalkane + H2O = a primary alcohol + halide
3 features are important for catalytic performance: i. a catalytic triad, ii. anoxyanion hole, and iii. the halide-stabilizing residues, which are not conserved among different haloalkane dehalogenases, active site structure, Glu56 is involved, SN2 reaction mechanism, modeling, overview
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1-haloalkane + H2O = a primary alcohol + halide
reaction mechanism, overview. The bromide release is the rate-limiting step of the catalytic cycle, overview
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1-haloalkane + H2O = a primary alcohol + halide
distinction of 3 different substrate classes for haloalkane dehalogenases after profound statistical reaction rate analysis
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1-haloalkane + H2O = a primary alcohol + halide
activation energy of reaction 59.5 kJ/mol
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(1-bromomethyl)cyclohexane + H2O
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(1S,3S)-2,3,4,5,6-pentachlorocyclohexanol + H2O
cis-2,3,5,6-tetrachlorocyclohexane-1,4-diol + chloride
(bromomethyl)cyclohexane + H2O
cyclohexylmethanol + bromide
(RS)-3-chloropropane-1,2-diol + NAD+
(R)-3-chloropropane-1,2-diol + 2-oxo-propionaldehyde + CH3COOH + Cl- + HCOOH + NADH
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1,1,2,3,4,5,6-heptachlorocyclohexane + H2O
2,3,4,4,5,6-hexachlorocyclohexanol + chloride
1,1,2-trichloroethane + H2O
? + chloride
1,2,3-tribromopropane + H2O
2,3-dibromo-1-propanol + bromide
1,2,3-tribromopropane + H2O
2,3-dibromopropanol + bromide
1,2,3-tribromopropane + H2O
?
1,2,3-trichloropropane + H2O
(RS)-2,3-dichloropropan-1-ol + chloride
1,2,3-trichloropropane + H2O
2,3-dichloro-1-propanol + chloride
1,2,3-trichloropropane + H2O
2,3-dichloropropan-1-ol + chloride
1,2,3-trichloropropane + H2O
2,3-dichloropropanol + chloride
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1,2,3-trichloropropane + H2O
2,3-dichlorpropane-1-ol + chloride
1,2,3-trichloropropane + H2O
?
1,2,3-trichloropropene + H2O
2,3-dichloropropenol + chloride
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?
1,2-dibromo-3-chloropropane
2-bromo-3-chloro-1-propanol + bromide
about 35% of the activity compared to 4-bromobutyronitrile
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?
1,2-dibromo-3-chloropropane + H2O
2-bromo-3-chloro-1-propanol + bromide
1,2-dibromo-3-chloropropane + H2O
2-bromo-3-chloropropanol + bromide
1,2-dibromoethane + H2O
2-bromo-1-ethanol + bromide
1,2-dibromoethane + H2O
2-bromoethanol + bromide
1,2-dibromoethane + H2O
bromoethanol + bromide
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?
1,2-dibromohexane + H2O
2-bromohexanol + bromide
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?
1,2-dibromopropane + H2O
2-bromo-1-propanol + bromide
1,2-dibromopropane + H2O
2-bromopropan-1-ol + bromide
1,2-dibromopropane + H2O
2-bromopropanol + bromide
1,2-dibromopropane + H2O
? + bromide
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1,2-dichlorobutane + H2O
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7.8% of the activity with 4-chlorobutanol
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1,2-dichloroethane + 2 H2O
1,2-ethanediol + 2 chloride
1,2-dichloroethane + H2O
2-chloro-1-ethanol + chloride
1,2-dichloroethane + H2O
2-chloroethanol + chloride
1,2-dichloroethane + H2O
?