Information on EC 3.8.1.11 - 2-haloacid dehalogenase (configuration-retaining)

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The expected taxonomic range for this enzyme is: Pseudomonas putida

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EC NUMBER
COMMENTARY hide
3.8.1.11
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RECOMMENDED NAME
GeneOntology No.
2-haloacid dehalogenase (configuration-retaining)
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(R)-2-haloacid + H2O = (R)-2-hydroxyacid + halide
show the reaction diagram
Dehalogenates both (S)- and (R)-2-haloalkanoic acids to the corresponding (S)- and (R)-hydroxyalkanoic acids, respectively, with retention of configuration at C-2. See also EC 3.8.1.2(S)-2-haloacid dehalogenase, EC 3.8.1.9 (R)-2-haloacid dehalogenase and EC 3.8.1.10 2-haloacid dehalogenase (configuration-inverting)
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(S)-2-haloacid + H2O = (S)-2-hydroxyacid + halide
show the reaction diagram
Dehalogenates both (S)- and (R)-2-haloalkanoic acids to the corresponding (S)- and (R)-hydroxyalkanoic acids, respectively, with retention of configuration at C-2. See also EC 3.8.1.2(S)-2-haloacid dehalogenase, EC 3.8.1.9 (R)-2-haloacid dehalogenase and EC 3.8.1.10 2-haloacid dehalogenase (configuration-inverting)
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
dehalogenation
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SYSTEMATIC NAME
IUBMB Comments
(S)-2-haloacid dehalogenase (configuration-retaining)
Dehalogenates both (S)- and (R)-2-haloalkanoic acids to the corresponding (S)- and (R)-hydroxyalkanoic acids, respectively, with retention of configuration at C-2. [See also EC 3.8.1.2 (S)-2-haloacid dehalogenase, EC 3.8.1.9 (R)-2-haloacid dehalogenase and EC 3.8.1.10 2-haloacid dehalogenase (configuration-inverting)]
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CAS REGISTRY NUMBER
COMMENTARY hide
89511-96-6
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(R)-2-haloacid + H2O
(R)-2-hydroxyacid + halide
show the reaction diagram
(S)-2-haloacid + H2O
(S)-2-hydroxyacid + halide
show the reaction diagram
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
(R)-2-haloacid + H2O
(R)-2-hydroxyacid + halide
show the reaction diagram
(S)-2-haloacid + H2O
(S)-2-hydroxyacid + halide
show the reaction diagram
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INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
N-ethylmaleimide
p-chloromercuribenzoate
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LINKS TO OTHER DATABASES (specific for EC-Number 3.8.1.11)
ExplorEnz
ExPASy
KEGG
MetaCyc
SABIO-RK
NCBI: PubMed, Protein, Nucleotide, Structure, Genome, OMIM
IUBMB Enzyme Nomenclature
PROSITE Database of protein families and domains
InterPro (database of protein families, domains and functional sites)