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Information on EC 3.8.1.10 - 2-haloacid dehalogenase (configuration-inverting) and Organism(s) Alcaligenes xylosoxydans xylosoxydans and UniProt Accession Q59168

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IUBMB Comments
Dehalogenates both (S)- and (R)-2-haloalkanoic acids to the corresponding (R)- and (S)-hydroxyalkanoic acids, respectively, with inversion of configuration at C-2. The enzyme from Pseudomonas sp. 113 acts on 2-haloalkanoic acids whose carbon chain lengths are five or less. [See also EC 3.8.1.2 (S)-2-haloacid dehalogenase, EC 3.8.1.9 (R)-2-haloacid dehalogenase and EC 3.8.1.11 2-haloacid dehalogenase (configuration-retaining)]
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Alcaligenes xylosoxydans xylosoxydans
UNIPROT: Q59168
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Word Map
The enzyme appears in selected viruses and cellular organisms
Synonyms
l-dex, l-2-haloacid dehalogenase, dl-2-haloacid dehalogenase, dl-dex, 2-haloalkanoic acid dehalogenase, ps-2-had, l-dex yl, 2-had, dl-dex 113, dl-dex mb, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
2-haloalkanoic acid dehalogenase
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2-haloalkanoid acid halidohydrolase
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DL DEX 113
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DL-2-haloacid dehalogenase
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DL-2-haloacid dehalogenase (inversion of configuration)
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DL-2-haloacid halidohydrolase (inversion of configuration)
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DL-DEXi
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
dehalogenation
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SYSTEMATIC NAME
IUBMB Comments
(S)-2-haloacid dehalogenase (configuration-inverting)
Dehalogenates both (S)- and (R)-2-haloalkanoic acids to the corresponding (R)- and (S)-hydroxyalkanoic acids, respectively, with inversion of configuration at C-2. The enzyme from Pseudomonas sp. 113 acts on 2-haloalkanoic acids whose carbon chain lengths are five or less. [See also EC 3.8.1.2 (S)-2-haloacid dehalogenase, EC 3.8.1.9 (R)-2-haloacid dehalogenase and EC 3.8.1.11 2-haloacid dehalogenase (configuration-retaining)]
CAS REGISTRY NUMBER
COMMENTARY hide
89511-96-6
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UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?