Information on EC 3.7.1.23 - maleylpyruvate hydrolase

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EC Tree
     3 Hydrolases
         3.7 Acting on carbon-carbon bonds
             3.7.1 In ketonic substances
                3.7.1.23 maleylpyruvate hydrolase
IUBMB Comments
The enzyme, characterized from the bacterium Pseudomonas alcaligenes NCIMB 9867, catalyses the hydrolysis of 3-maleylpyruvate, the ring-cleavage product of gentisate. The enzyme can also act on a number of maleylpyruvate derivatives, such as (2E)-2-methyl-4,6-dioxohept-2-enedioate and (2E)-3-methyl-4,6-dioxohept-2-enedioate. Activated by Mn2+. May be identical to EC 3.7.1.5, acylpyruvate hydrolase.
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The enzyme appears in viruses and cellular organisms
Synonyms
hbzF, maleylpyruvate hydrolase, maleylpyruvate hydrolase I, maleylpyruvate hydrolase II, Mph, MPH11, SLG_11280, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
3-maleylpyruvate + H2O = maleate + pyruvate
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