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Information on EC 3.7.1.14 - 2-hydroxy-6-oxonona-2,4-dienedioate hydrolase

for references in articles please use BRENDA:EC3.7.1.14
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IUBMB Comments
This enzyme catalyses a step in a pathway of phenylpropanoid compounds degradation. The first step of the enzyme mechanism involves a reversible keto-enol tautomerization .
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This record set is specific for:
UNIPROT: P0ABW0
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The expected taxonomic range for this enzyme is: Bacteria, Archaea, Eukaryota
Synonyms
2-hydroxy-6-ketonona-2,4-diene-1,9-dioic acid 5,6-hydrolase, more
SYSTEMATIC NAME
IUBMB Comments
(2E,4Z)-2-hydroxy-6-oxona-2,4-dienedioate succinylhydrolase
This enzyme catalyses a step in a pathway of phenylpropanoid compounds degradation. The first step of the enzyme mechanism involves a reversible keto-enol tautomerization [4].
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(2E,4Z)-2-hydroxy-6-oxonona-2,4-dienedioate + H2O
(2E)-2-hydroxypenta-2,4-dienoate + succinate
show the reaction diagram
the enzyme is involved in 3-phenylpropanoate catabolism
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
(2E,4Z)-2-hydroxy-6-oxonona-2,4-dienedioate + H2O
(2E)-2-hydroxypenta-2,4-dienoate + succinate
show the reaction diagram
the enzyme is involved in 3-phenylpropanoate catabolism
-
-
?
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
SwissProt
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
the enzyme is involved in 3-phenylpropanoate catabolism
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
HCAC_ECOLI
Escherichia coli (strain K12)
106
0
11329
Swiss-Prot
-
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Diaz, E.; Ferrandez, A.; Garcia, J.L.
Characterization of the hca cluster encoding the dioxygenolytic pathway for initial catabolism of 3-phenylpropionic acid in Escherichia coli K-12
J. Bacteriol.
180
2915-2923
1998
Escherichia coli (P0ABW0)
Manually annotated by BRENDA team