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Information on EC 3.6.5.4 - signal-recognition-particle GTPase

for references in articles please use BRENDA:EC3.6.5.4
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EC Tree
IUBMB Comments
Activity is associated with the signal-recognition particle (a protein- and RNA-containing structure involved in endoplasmic-reticulum-associated protein synthesis).
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This record set is specific for:
UNIPROT: Q9P372
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Word Map
  • 3.6.5.4
  • gtpases
  • ribonucleoprotein
  • co-translational
  • translocons
  • srp-dependent
  • thylakoids
  • sec
  • exit
  • light-harvesting
  • myopathy
  • secyeg
  • cotranslationally
  • universally
  • gtp-binding
  • myositis
  • translocase
  • presecretory
  • tetraloops
  • insertase
  • polytopic
  • anti-srp
  • methionine-rich
  • ribosome-associated
  • rna-protein
  • preproteins
  • protein-targeting
  • signal-anchor
  • m-domain
  • ribosome-bound
  • chromodomains
  • medicine
  • polymyositis
  • protein-conducting
  • anti-signal
  • protein-rna
  • chlorophyll-binding
  • gtp-bound
  • walter
  • multispanning
  • imnms
  • sequence-binding
  • myositis-specific
  • tail-anchored
The expected taxonomic range for this enzyme is: Archaea, Eukaryota, Bacteria
Reaction Schemes
Synonyms
signal recognition particle, srp54, srp receptor, srp19, cpsrp43, cpsrp54, cpsrp, srp14, sralpha, cpftsy, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
signal recognition particle
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SRP14
signal recognition particle subunit
GTPase
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guanine triphosphatase
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guanosine 5'-triphosphatase
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guanosine triphosphatase
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ribosomal GTPase
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of phosphoric ester
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SYSTEMATIC NAME
IUBMB Comments
GTP phosphohydrolase (protein-synthesis-assisting)
Activity is associated with the signal-recognition particle (a protein- and RNA-containing structure involved in endoplasmic-reticulum-associated protein synthesis).
CAS REGISTRY NUMBER
COMMENTARY hide
9059-32-9
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
GTP + H2O
GDP + phosphate
show the reaction diagram
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-
-
?
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
SRP14_SCHPO
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
106
0
11718
Swiss-Prot
-
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
homodimer
subunit SRP14, X-ray crystallography
CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
hanging drop vapour diffusion method, at 21°C, using 50 mM cacodylic acid pH 6.5, 22% (w/v) PEG 4000, and 50 mM sodium acetate
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
HiPrep heparin Sepharose column chromatography, SP Sepharose column chromatography, and Superdex 75 gel filtration
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expressed in Escherichia coli BL21-AI cells
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Brooks, M.A.; Ravelli, R.B.; McCarthy, A.A.; Strub, K.; Cusack, S.
Structure of SRP14 from the Schizosaccharomyces pombe signal recognition particle
Acta Crystallogr. Sect. D
65
421-433
2009
Schizosaccharomyces pombe, Schizosaccharomyces pombe (Q9P372)
Manually annotated by BRENDA team