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Information on EC 3.6.5.3 - protein-synthesizing GTPase and Organism(s) Homo sapiens and UniProt Accession P41091
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3.6.5.3 protein-synthesizing GTPaseIUBMB Comments
This enzyme comprises a family of proteins involved in prokaryotic as well as eukaryotic protein synthesis. In the initiation factor complex, it is IF-2b (98 kDa) that binds GTP and subsequently hydrolyses it in prokaryotes. In eukaryotes, it is eIF-2 (150 kDa) that binds GTP. In the elongation phase, the GTP-hydrolysing proteins are the EF-Tu polypeptide of the prokaryotic transfer factor (43 kDa), the eukaryotic elongation factor EF-1alpha (53 kDa), the prokaryotic EF-G (77 kDa), the eukaryotic EF-2 (70-110 kDa) and the signal recognition particle that play a role in endoplasmic reticulum protein synthesis (325 kDa). EF-Tu and EF-1alpha catalyse binding of aminoacyl-tRNA to the ribosomal A-site, while EF-G and EF-2 catalyse the translocation of peptidyl-tRNA from the A-site to the P-site. GTPase activity is also involved in polypeptide release from the ribosome with the aid of the pRFs and eRFs.
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- 3.6.5.3
- gtpases
- eif4e
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spacer
- ras
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1-alpha
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chop
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rna-dependent
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gtp-binding
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aminoacylated
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cap-dependent
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adp-ribosylation
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pausing
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monophyletic
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wilt
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stall
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normfinder
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genorm
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hyaline
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- medicine
The taxonomic range for the selected organisms is: Homo sapiens
The enzyme appears in selected viruses and cellular organisms
The enzyme appears in selected viruses and cellular organisms
Synonyms
elongation factor, translation initiation factor, gtpase-activating protein, eif2alpha, eif2b, elongation factor tu, eef1a, ef-1alpha, eukaryotic initiation factor 2, elongation factor g, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
elongation factor (EF)
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GTP phosphohydrolase
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GTPase
guanine triphosphatase
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guanosine 5'-triphosphatase
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guanosine triphosphatase
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initiation factor (IF)
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peptide-release or termination factor
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ribosomal GTPase
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GTPase
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
hydrolysis of phosphoric ester
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-
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SYSTEMATIC NAME
IUBMB Comments
GTP phosphohydrolase (mRNA-translation-assisting)
This enzyme comprises a family of proteins involved in prokaryotic as well as eukaryotic protein synthesis. In the initiation factor complex, it is IF-2b (98 kDa) that binds GTP and subsequently hydrolyses it in prokaryotes. In eukaryotes, it is eIF-2 (150 kDa) that binds GTP. In the elongation phase, the GTP-hydrolysing proteins are the EF-Tu polypeptide of the prokaryotic transfer factor (43 kDa), the eukaryotic elongation factor EF-1alpha (53 kDa), the prokaryotic EF-G (77 kDa), the eukaryotic EF-2 (70-110 kDa) and the signal recognition particle that play a role in endoplasmic reticulum protein synthesis (325 kDa). EF-Tu and EF-1alpha catalyse binding of aminoacyl-tRNA to the ribosomal A-site, while EF-G and EF-2 catalyse the translocation of peptidyl-tRNA from the A-site to the P-site. GTPase activity is also involved in polypeptide release from the ribosome with the aid of the pRFs and eRFs.
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CAS REGISTRY NUMBER
COMMENTARY
9059-32-9
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
GTP + H2O
GDP + phosphate
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GTPase activation due to C domain of the translation termination factor eRF1, which is bound with translation termination factor eRF3. As for the M and N domains, stimulation of eRF3 GTPase activity is more likely associated with the former, which is located in the large subunit along with the GTPase center of the ribosome, than with the latter, which is oriented towards the decoding center located in the small ribosomal subunit
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?
additional information
?
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elongation factor eEF2 catalyzes ribosomal reverse translocation at one mRNA triplet. This process requires a cognate tRNA in the ribosomal E-site and cannot occur spontaneously without eEF2. The efficiency of this reaction depends on the concentrations of eEF2 and cognate tRNAs and increases in the presence of nonhydrolyzable GTP analogues. Deacylated tRNAHis, cognate to the E-site codon, to the POST ribosomal complexes along with eEF2-GTP, causes a shift of the main toeprint peak by 3 nt toward the 5' end of the mRNA. POST ribosomes relocate backwards by three nucleotides in the presence of cognate deacylated tRNA and eEF2. Reverse translocation required up to a 20fold excess of eEF2 over the ribosomal complexes, whereas direct translocation is effective at a 2:1 ratio. Model of eEF2-catalyzed reverse translocation, overview
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additional information
?
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P05198; P20042; P41091
substrate eIF2, phosphorylation of the eIF2alpha subunit in response to various cellular stresses converts substrate eIF2 into a competitive inhibitor of eIF2B, which triggers the integrated stress response (ISR)
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Mg2+
additional information
high concentrations of Mg2+ and spermidine doe not induce spontaneous reverse translocation, as has been reported
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
cycloheximide
added to the POST complexes in the presence of eEF2 and deacylated tRNAHis, it blocks the -3 nt shift that supports the reverse translocation model
hygromycin B
the antibiotic effectively inhibits translocation of mRNA and tRNAs on the ribosome in both bacteria and eukaryotes. Hygromycin B blocks the toeprint shift induced by eEF2 and deacylated tRNA
phosphorylated eIF2
P05198; P20042; P41091
IF2alpha is phosphorylated at Ser51 by four kinases in what is collectively known as the integrated stress response (ISR). Phosphorylation of the eIF2alpha subunit in response to various cellular stresses converts eIF2-GDP into a competitive inhibitor of eIF2B, which triggers the integrated stress response (ISR)
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additional information
ADP-ribosylation of eEF2 domain IV blocks reverse translocation activity of eEF2. ADP-ribosylation may directly interrupt the ability of eEF2 to stabilize the intermediate conformation of the tRNA ends during their movement through the SSU in the course of translocation
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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
eIF1A
GTPase-activating protein (GAP) for eIF2, the interaction is mediated by an eIF5B-binding motif located at the C-terminus of eIF1A. The C-terminal tail of eIF1A is located in the ribosomal P-site and counteracts the transition from open to closed complex. EIF5 competes with eIF1A for binding to eIF5B
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GMP-PCP
non-hydrolyzable or slowly hydrolyzable GTP analogues such as GMP-PCP and GMP-PNP, able to stall elongation factor on the ribosome, increase the efficiency of the reverse translocation reaction
GMP-PNP
non-hydrolyzable or slowly hydrolyzable GTP analogues such as GMP-PCP and GMP-PNP, able to stall elongation factor on the ribosome, increase the efficiency of the reverse translocation reaction
eIF5
eIF5 is the GTPase-activating protein (GAP) of eIF2, eIF5 promotes GTP hydrolysis by eIF2, followed by phosphate release. EIF2-GDP has lower affinity for Met-tRNAi than eIF2-GTP, and is released together with its GAP, eIF5
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eIF5
human eIF5, the GTPase-activating protein (GAP) for eIF2, also binds to eIF5B, with affinity that is about two orders of magnitude higher than that of eIF1A. The interaction is mediated by an eIF5B-binding motif located at the C-terminus of eIF5, similar to that of eIF1A and the two proteins compete for binding to eIF5B. NMR structure analysis of the binding interface between eIF5-CT39 and eIF5B-D4, structure of the human eIF5B-D4-eIF5-C-terminal tail (CTT) complex, overview
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additional information
evolutionary conservation of the eIF5B-binding motif in eIF1A and eIF5
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additional information
P05198; P20042; P41091
evolutionary conservation of the eIF5B-binding motif in eIF1A and eIF5
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additional information
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evolutionary conservation of the eIF5B-binding motif in eIF1A and eIF5
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additional information
presence of nonhydrolyzable GTP analogues increases the reverse translocation at mRNA activity of eukaryotic elongation factor eEF2. Reverse translocation requires an excessive concentration of cognate deacylated tRNA
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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Abortion, Spontaneous
Proteomic analysis on the alteration of protein expression in the placental villous tissue of early pregnancy loss.
Abortion, Spontaneous
Spliceosome protein EFTUD2 is upregulated in the trophoblast of spontaneous miscarriage and hydatidiform mole.
Acidosis
Simultaneous Hypoxia and Low Extracellular pH Suppress Overall Metabolic Rate and Protein Synthesis In Vitro.
Acquired Immunodeficiency Syndrome
Elongation factor NusG interacts with termination factor rho to regulate termination and antitermination of transcription.
Acquired Immunodeficiency Syndrome
Elongation factor-P at the crossroads of the host-endosymbiont interface.
Acquired Immunodeficiency Syndrome
In vivo biochemical analyses reveal distinct roles of ?-importins and eEF1A in tRNA subcellular traffic.
Acquired Immunodeficiency Syndrome
The Interaction of CCDC104/BARTL1 with Arl3 and Implications for Ciliary Function.
Acute Lung Injury
Eukaryotic Translation Initiation Factor 5A Small Interference RNA-Liposome Complexes Reduce Inflammation and Increase Survival in Murine Models of Severe Sepsis and Acute Lung Injury.
Adenocarcinoma
A chemical genomics-aggrephagy integrated method studying functional analysis of autophagy inducers.
Adenocarcinoma
A pan-cancer genome-wide analysis reveals tumour dependencies by induction of nonsense-mediated decay.
Adenocarcinoma
ARHGAP25 Inhibits Pancreatic Adenocarcinoma Growth by Suppressing Glycolysis via AKT/mTOR Pathway.
Adenocarcinoma
Decreased expression of ARHGAP15 promotes the development of colorectal cancer through PTEN/AKT/FOXO1 axis.
Adenocarcinoma
Decreased expression of transcription elongation factor A-like 7 is associated with gastric adenocarcinoma prognosis.
Adenocarcinoma
Differential screening of a human pancreatic adenocarcinoma lambda gt11 expression library has identified increased transcription of elongation factor EF-1 alpha in tumour cells.
Adenocarcinoma
eIF5A-PEAK1 Signaling Regulates YAP1/TAZ Protein Expression and Pancreatic Cancer Cell Growth.
Adenocarcinoma
Eukaryotic translation initiation factor 4E (eIF-4E) expressions are associated with poor prognosis in colorectal adenocarcinoma.
Adenocarcinoma
Expression of an elongation factor 1 gamma-related sequence in adenocarcinomas of the colon.
Adenocarcinoma
Expression of Elongation Factor (EF)-Tu Is Correlated with Prognosis of Gastric Adenocarcinomas.
Adenocarcinoma
IQGAP1 Maintains Pancreatic Ductal Adenocarcinoma Clonogenic Growth and Metastasis.
Adenocarcinoma
N1-guanyl-1, 7-diaminoheptane enhances the sensitivity of pancreatic ductal adenocarcinoma cells to gemcitabine via the inhibition of eukaryotic translation initiation factor 5A2.
Adenocarcinoma
Ral GTPase-activating protein regulates the malignancy of pancreatic ductal adenocarcinoma.
Adenocarcinoma
[Expression of eukaryotic translation initiation factor 5A2 in pancreatic adenocarcinoma and its correlation with the prognosis].
Adenocarcinoma of Lung
Curcumin modulates eukaryotic initiation factors in human lung adenocarcinoma epithelial cells.
Adenocarcinoma of Lung
eIF5B drives integrated stress response-dependent translation of PD-L1 in lung cancer.
Adenocarcinoma of Lung
Expression and prognostic analysis of Rho GTPase-activating protein 11A in lung adenocarcinoma.
Adenocarcinoma of Lung
p190A RhoGAP is involved in EGFR pathways and promotes proliferation, invasion and migration in lung adenocarcinoma cells.
Adenocarcinoma of Lung
Sumoylation of eukaryotic elongation factor 2 is vital for protein stability and anti-apoptotic activity in lung adenocarcinoma cells.
Adenocarcinoma of Lung
[Rho GTPase-activating protein 11A (ARHGAP11A) is up-regulated in lung adenocarcinoma and positively associated with poor prognosis].
Adenoma
Gene Expression in Mouse Thyrotrope Adenoma: Transcription Elongation Factor Stimulates Proliferation.
Adenoma
The value of histomorphometric nuclear parameters in the diagnosis of well differentiated follicular carcinomas and follicular adenomas of the thyroid gland.
Adenomatous Polyposis Coli
Identification of the target proteins of rosiglitazone in 3T3-L1 adipocytes through proteomic analysis of cytosolic and secreted proteins.
Adenomatous Polyposis Coli
IQ-domain GTPase-activating protein 1 regulates beta-catenin at membrane ruffles and its role in macropinocytosis of N-cadherin and adenomatous polyposis coli.
Adenomyosis
RhoA/ROCK/ARHGAP26 signaling in the eutopic and ectopic endometrium is involved in clinical characteristics of adenomyosis.
Adenomyosis
The Possible Role of Eukaryotic Translation Initiation Factor 3 Subunit e (eIF3e) in the Epithelial-Mesenchymal Transition in Adenomyosis.
Adrenoleukodystrophy
ABC transportome inventory of human pathogenic yeast Candida glabrata: Phylogenetic and expression analysis.
African Swine Fever
Identification of residues within the African swine fever virus DP71L protein required for dephosphorylation of translation initiation factor eIF2? and inhibiting activation of pro-apoptotic CHOP.
African Swine Fever
Promoter analysis of an African swine fever virus gene encoding a putative elongation factor.
African Swine Fever
The African swine fever virus DP71L protein recruits the protein phosphatase 1 catalytic subunit to dephosphorylate eIF2alpha and inhibits CHOP induction but is dispensable for these activities during virus infection.
Albuminuria
MicroRNA-23b Targets Ras GTPase-Activating Protein SH3 Domain-Binding Protein 2 to Alleviate Fibrosis and Albuminuria in Diabetic Nephropathy.
Alzheimer Disease
Activation of eukaryotic initiation factor-2 alpha-kinases in okadaic acid-treated neurons.
Alzheimer Disease
Alpha1-chimaerin, a Rac1 GTPase-activating protein, is expressed at reduced mRNA levels in the brain of Alzheimer's disease patients.
Alzheimer Disease
Basal levels of eIF2alpha phosphorylation determine cellular antioxidant status by regulating ATF4 and xCT expression.
Alzheimer Disease
Differential expression of phosphorylated translation initiation factor 2 alpha in Alzheimer's disease and Creutzfeldt-Jakob's disease.
Alzheimer Disease
Dysregulation of Elongation Factor 1A Expression is Correlated with Synaptic Plasticity Impairments in Alzheimer's Disease.
Alzheimer Disease
Genetic inhibition of phosphorylation of the translation initiation factor eIF2? does not block A?-dependent elevation of BACE1 and APP levels or reduce amyloid pathology in a mouse model of Alzheimer's disease.
Alzheimer Disease
Impaired Eukaryotic Elongation Factor 1A Expression in Alzheimer's Disease.
Alzheimer Disease
Limited effects of an eIF2?S51A allele on neurological impairments in the 5xFAD mouse model of Alzheimer's disease.
Alzheimer Disease
Minocycline attenuates neuronal cell death and improves cognitive impairment in Alzheimer's disease models.
Alzheimer Disease
Organelle-specific autophagy in inflammatory diseases: a potential therapeutic target underlying the quality control of multiple organelles.
Alzheimer Disease
Pathogenesis and promising therapeutics of Alzheimer disease through eIF2? pathway and correspondent kinases.
Alzheimer Disease
Upstream signaling pathways leading to the activation of double-stranded RNA-dependent serine/threonine protein kinase in beta-amyloid peptide neurotoxicity.
Ameloblastoma
Upregulation of eukaryotic translation initiation factor 3 subunit a promotes cell survival in ameloblastoma.
Amyotrophic Lateral Sclerosis
ALS-FTLD-linked mutations of SQSTM1/p62 disrupt selective autophagy and NFE2L2/NRF2 anti-oxidative stress pathway.
Amyotrophic Lateral Sclerosis
C9orf72 ALS-FTD: recent evidence for dysregulation of the autophagy-lysosome pathway at multiple levels.
Amyotrophic Lateral Sclerosis
Organelle-specific autophagy in inflammatory diseases: a potential therapeutic target underlying the quality control of multiple organelles.
Anemia
An in vitro transcription system that recapitulates equine infectious anemia virus tat-mediated inhibition of human immunodeficiency virus type 1 Tat activity demonstrates a role for positive transcription elongation factor b and associated proteins in the mechanism of Tat activation.
Anemia
Lentiviral Vectors with Cellular Promoters Correct Anemia and Lethal Bone Marrow Failure in a Mouse Model for Diamond-Blackfan Anemia.
Anemia
Validation of reference genes for real-time polymerase chain reaction studies in atlantic salmon.
Anemia, Diamond-Blackfan
Lentiviral Vectors with Cellular Promoters Correct Anemia and Lethal Bone Marrow Failure in a Mouse Model for Diamond-Blackfan Anemia.
Angiomyolipoma
Human TSC-associated renal angiomyolipoma cells are hypersensitive to ER stress.
Arthritis
Fluvastatin prevents the development of arthritis in env-pX rats via up-regulation of Rho GTPase-activating protein 12.
Arthritis, Rheumatoid
Identification of citrullinated eukaryotic translation initiation factor 4G1 as novel autoantigen in rheumatoid arthritis.
Arthritis, Rheumatoid
Identification of new autoantigens for primary biliary cirrhosis using human proteome microarrays.
Astrocytoma
Schweinfurthin A Selectively Inhibits Proliferation and Rho Signaling in Glioma and Neurofibromatosis Type 1 Tumor Cells in a NF1-GRD-Dependent Manner.
Ataxia
A Japanese girl with an early-infantile onset vanishing white matter disease resembling Cree leukoencephalopathy.
Ataxia
A point mutation in translation initiation factor 2B leads to a continuous hyper stress state in oligodendroglial-derived cells.
Ataxia
A point mutation in translation initiation factor eIF2B leads to function--and time-specific changes in brain gene expression.
Ataxia
A severe variant of childhood ataxia with central hypomyelination/vanishing white matter leukoencephalopathy related to EIF21B5 mutation.
Ataxia
A yeast purification system for human translation initiation factors eIF2 and eIF2B? and their use in the diagnosis of CACH/VWM disease.
Ataxia
De novo EIF2AK1 and EIF2AK2 Variants Are Associated with Developmental Delay, Leukoencephalopathy, and Neurologic Decompensation.
Ataxia
Discovery of Chemical Modulators of a Conserved Translational Control Pathway by Parallel Screening in Yeast.
Ataxia
Eif2b3 mutants recapitulate phenotypes of vanishing white matter disease and validate novel disease alleles in zebrafish.
Ataxia
Foetal onset of EIF2B related disorder in two siblings: cerebellar hypoplasia with absent Bergmann glia and severe hypomyelination.
Ataxia
Leukoencephalopathy with vanishing white matter due to homozygous EIF2B2 gene mutation. First Polish cases.
Ataxia
Membrane phospholipids and high-energy metabolites in childhood ataxia with CNS hypomyelination.
Ataxia
Molecular-genetic characterization and rescue of a TSFM mutation causing childhood-onset ataxia and nonobstructive cardiomyopathy.
Ataxia
Mutations causing childhood ataxia with central nervous system hypomyelination reduce eukaryotic initiation factor 2B complex formation and activity.
Ataxia
Profile of Indian Children with Childhood Ataxia and Central Nervous System Hypomyelination/Vanishing White Matter Disease: A Single Center Experience from Southern India.
Ataxia Telangiectasia
Hydrogen Indirectly Suppresses Increases in Hydrogen Peroxide in Cytoplasmic Hydroxyl Radical-Induced Cells and Suppresses Cellular Senescence.
Atherosclerosis
Activation of aldehyde dehydrogenase 2 slows down the progression of atherosclerosis via attenuation of ER stress and apoptosis in smooth muscle cells.
Atrial Fibrillation
Small-Molecule Integrated Stress Response Inhibitor Reduces Susceptibility to Postinfarct Atrial Fibrillation in Rats via the Inhibition of Integrated Stress Responses.
Atypical Squamous Cells of the Cervix
MoSnt2-dependent deacetylation of histone H3 mediates MoTor-dependent autophagy and plant infection by the rice blast fungus Magnaporthe oryzae.
Azoospermia
Ehrlichia chaffeensis TRP32 interacts with host cell targets that influence intracellular survival.
Bacteremia
Comparative Exoproteomics and Host Inflammatory Response in Staphylococcus aureus Skin and Soft Tissue Infections, Bacteremia, and Subclinical Colonization.
Bacterial Infections
Evaluation of candidate reference genes for quantitative expression studies in Asian seabass (Lates calcarifer) during ontogenesis and in tissues of healthy and infected fishes.
Bacterial Infections
Evaluation of potential internal references for quantitative real-time RT-PCR normalization of gene expression in red drum (Sciaenops ocellatus).
Blast Crisis
Increased c-Myc activity and DNA damage in hematopoietic progenitors precede myeloproliferative disease in Spa-1-deficiency.
Blister
Mechanical strain in actin networks regulates FilGAP and integrin binding to filamin A.
Bone Marrow Failure Disorders
Lentiviral Vectors with Cellular Promoters Correct Anemia and Lethal Bone Marrow Failure in a Mouse Model for Diamond-Blackfan Anemia.
Brain Diseases
Discovery of Chemical Modulators of a Conserved Translational Control Pathway by Parallel Screening in Yeast.
Brain Diseases
eIF2B-related disorders: antenatal onset and involvement of multiple organs.
Brain Diseases
Generation of a human iPSC line from a patient with a mitochondrial encephalopathy due to mutations in the GFM1 gene.
Brain Diseases
Identification of a Missense Variant in the EIF2B3 Gene Causing Vanishing White Matter Disease with Antenatal-Onset but Mild Symptoms and Long-Term Survival.
Brain Diseases
Mild epileptic phenotype associates with de novo eef1a2 mutation: Case report and review.
Brain Diseases
Mutation in subdomain G' of mitochondrial elongation factor G1 is associated with combined OXPHOS deficiency in fibroblasts but not in muscle.
Brain Diseases
Mutations causing childhood ataxia with central nervous system hypomyelination reduce eukaryotic initiation factor 2B complex formation and activity.
Brain Diseases
Poor cerebral inflammatory response in eIF2B knock-in mice: implications for the aetiology of vanishing white matter disease.
Brain Diseases
Recessive Inactivating Mutations in TBCK, Encoding a Rab GTPase-Activating Protein, Cause Severe Infantile Syndromic Encephalopathy.
Brain Diseases
Successful treatment of choreo-athetotic movements in a patient with an EEF1A2 gene variant.
Brain Diseases
The R336Q mutation in human mitochondrial EFTu prevents the formation of an active mt-EFTu.GTP.aa-tRNA ternary complex.
Brain Injuries
Immunohistochemical mapping of total and phosphorylated eukaryotic initiation factor 4G in rat hippocampus following global brain ischemia and reperfusion.
Brain Injuries
Structure of the nucleotide exchange factor eIF2B reveals mechanism of memory-enhancing molecule.
Brain Injuries, Traumatic
Binding of ISRIB reveals a regulatory site in the nucleotide exchange factor eIF2B.
Brain Injuries, Traumatic
Inhibition of Eukaryotic Initiation Factor 2 Alpha Phosphatase Reduces Tissue Damage and Improves Learning and Memory after Experimental Traumatic Brain Injury.
Brain Ischemia
Brain ischemia and reperfusion activates the eukaryotic initiation factor 2alpha kinase, PERK.
Brain Ischemia
Characterization of the eIF2-associated protein p67 during brain ischemia and reperfusion.
Brain Ischemia
Effect of brain ischemia and reperfusion on the localization of phosphorylated eukaryotic initiation factor 2 alpha.
Brain Ischemia
PERK is responsible for the increased phosphorylation of eIF2alpha and the severe inhibition of protein synthesis after transient global brain ischemia.
Brain Ischemia
Regulatory proteins of eukaryotic initiation factor 2-alpha subunit (eIF2alpha) phosphatase, under ischemic reperfusion and tolerance.
Brain Ischemia
Stress Granule Induction after Brain Ischemia Is Independent of Eukaryotic Translation Initiation Factor (eIF) 2? Phosphorylation and Is Correlated with a Decrease in eIF4B and eIF4E Proteins.
Brain Ischemia
Stress-induced inhibition of protein synthesis initiation: modulation of initiation factor 2 and guanine nucleotide exchange factor activities following transient cerebral ischemia in the rat.
Brain Neoplasms
Eukaryotic initiation factor 5B (eIF5B) regulates temozolomide-mediated apoptosis in brain tumor stem cells (BTSCs).
Brain Neoplasms
Eukaryotic Initiation Factors (eIF) 2{alpha} and 4E Expression, Localization, and Phosphorylation in Brain Tumors.
Breast Neoplasms
4EGI-1 targets breast cancer stem cells by selective inhibition of translation that persists in CSC maintenance, proliferation and metastasis.
Breast Neoplasms
A transcriptional complex composed of ER(?), GATA3, FOXA1 and ELL3 regulates IL-20 expression in breast cancer cells.
Breast Neoplasms
Acetylation of ACAP4 regulates CCL18-elicited breast cancer cell migration and invasion.
Breast Neoplasms
Activation of the PERK-eIF2? Pathway Is Associated with Tumor-infiltrating Lymphocytes in HER2-Positive Breast Cancer.
Breast Neoplasms
Autoantibodies to Annexin XI-A and Other Autoantigens in the Diagnosis of Breast Cancer.
Breast Neoplasms
Cytoprotective effect of the elongation factor-2 kinase-mediated autophagy in breast cancer cells subjected to growth factor inhibition.
Breast Neoplasms
Decreased microRNA-768-3p expression indicates a poor prognosis in patients with breast cancer and promotes breast cancer cell viability, migration and invasion.
Breast Neoplasms
DNA damage and eIF4G1 in breast cancer cells reprogram translation for survival and DNA repair mRNAs.
Breast Neoplasms
Downregulation of IQGAP1 inhibits epithelial-mesenchymal transition via the HIF1?/VEGF-A signaling pathway in gastric cancer.
Breast Neoplasms
Droplet digital PCR using HER2/EIF2C1 ratio for detection of HER2 amplification in breast cancer tissues.
Breast Neoplasms
EIF2A promotes cell survival during paclitaxel treatment in vitro and in vivo.
Breast Neoplasms
Elevated expression of eIF4E and FGF-2 isoforms during vascularization of breast carcinomas.
Breast Neoplasms
Elongation Factor 1 alpha interacts with phospho-Akt in breast cancer cells and regulates their proliferation, survival and motility.
Breast Neoplasms
Essential role for Rac in heregulin beta1 mitogenic signaling: a mechanism that involves epidermal growth factor receptor and is independent of ErbB4.
Breast Neoplasms
Eukaryotic initiation factor 4E (eIF4E) and angiogenesis: prognostic markers for breast cancer.
Breast Neoplasms
Eukaryotic translation initiation factor 4E (eIF4E) expression is associated with breast cancer tumor phenotype and predicts survival after anthracycline chemotherapy treatment.
Breast Neoplasms
Expression of protein elongation factor eEF1A2 predicts favorable outcome in breast cancer.
Breast Neoplasms
Expression of the actin-binding proteins indicates that cofilin and fascin are related to breast tumour size.
Breast Neoplasms
Heregulin induces expression, ATPase activity, and nuclear localization of G3BP, a Ras signaling component, in human breast tumors.
Breast Neoplasms
Identification and validation of AIB1 and EIF5A2 for noninvasive detection of bladder cancer in urine samples.
Breast Neoplasms
Identification of a Selective SIRT2 Inhibitor and Its Anti-breast Cancer Activity.
Breast Neoplasms
Increased proteasome activity, ubiquitin-conjugating enzymes, and eEF1A translation factor detected in breast cancer tissue.
Breast Neoplasms
Investigation of the eIF2alpha phosphorylation mechanism in response to proteasome inhibition in melanoma and breast cancer cells.
Breast Neoplasms
Involvement of Ras GTPase-activating protein SH3 domain-binding protein 1 in the epithelial-to-mesenchymal transition-induced metastasis of breast cancer cells via the Smad signaling pathway.
Breast Neoplasms
IQ Motif Containing GTPase-Activating Protein 3 (IQGAP3) Inhibits Kaempferol-Induced Apoptosis in Breast Cancer Cells by Extracellular Signal-Regulated Kinases 1/2 (ERK1/2) Signaling Activation.
Breast Neoplasms
IQ-domain GTPase-activating protein 1 promotes the malignant phenotype of invasive ductal breast carcinoma via canonical Wnt pathway.
Breast Neoplasms
IQGAP1 modulates the proliferation and invasion of thyroid cancer cells in response to estrogen.
Breast Neoplasms
LINCS gene expression signature analysis revealed bosutinib as a radiosensitizer of breast cancer cells by targeting eIF4G1.
Breast Neoplasms
Long non-coding RNA NORAD inhibition upregulates microRNA-323a-3p to suppress tumorigenesis and development of breast cancer through the PUM1/eIF2 axis.
Breast Neoplasms
mrtl-A translation/localization regulatory protein encoded within the human c-myc locus and distributed throughout the endoplasmic and nucleoplasmic reticular network.
Breast Neoplasms
N1-Guanyl-1,7-Diaminoheptane Sensitizes Estrogen Receptor Negative Breast Cancer Cells to Doxorubicin by Preventing Epithelial-Mesenchymal Transition through Inhibition of Eukaryotic Translation Initiation Factor 5A2 Activation.
Breast Neoplasms
Non-nuclear localized human NOSII enhances the bioactivation and toxicity of tirapazamine (SR4233) in vitro.
Breast Neoplasms
Paclitaxel suppresses the viability of breast tumor MCF7 cells through the regulation of EF1? and FOXO3a by AMPK signaling.
Breast Neoplasms
Parthenolide reduces metastasis by inhibition of vimentin expression and induces apoptosis by suppression elongation factor ??-?1 expression.
Breast Neoplasms
PERK-Phosphorylated eIF2? Pathway Suppresses Tumor Metastasis Through Downregulating Expression of Programmed Death Ligand 1 and CXCL5 in Triple-Negative Breast Cancer.
Breast Neoplasms
PRMT7 Methylates Eukaryotic Translation Initiation Factor 2? and Regulates its Role in Stress Granule Formation.
Breast Neoplasms
RAS protein activator-like 1 is functionally involved in hypoxia resistance in breast cancer cells by targeting hypoxia inducible factor-1?.
Breast Neoplasms
RNA Interference of IQ Motif Containing GTPase-Activating Protein 3 (IQGAP3) Inhibits Cell Proliferation and Invasion in Breast Carcinoma Cells.
Breast Neoplasms
RSK-mediated down-regulation of PDCD4 is required for proliferation, survival, and migration in a model of triple-negative breast cancer.
Breast Neoplasms
Targeted Dual pH-Sensitive Lipid ECO/siRNA Self-Assembly Nanoparticles Facilitate In Vivo Cytosolic sieIF4E Delivery and Overcome Paclitaxel Resistance in Breast Cancer Therapy.
Breast Neoplasms
Targeting of the Eukaryotic Translation Initiation Factor 4A Against Breast Cancer Stemness.
Breast Neoplasms
The effect of eIF3a on anthracycline-based chemotherapy resistance by regulating DSB DNA repair.
Breast Neoplasms
Translation elongation factor eEF1A2 is a potential oncoprotein that is overexpressed in two-thirds of breast tumours.
Bronchitis
Inhibition of PKR Activation and Up-regulation of GADD34 Expression Play a Synergistic Role in Facilitating Coronavirus Replication by Maintaining de novo Protein Synthesis in Virus-Infected Cells.
Burkholderia Infections
Immunospecific responses to bacterial elongation factor Tu during Burkholderia infection and immunization.
Burkitt Lymphoma
Resveratrol-induced cytotoxicity in human Burkitt's lymphoma cells is coupled to the unfolded protein response.
Buruli Ulcer
Inhibition of the SEC61 translocon by mycolactone induces a protective autophagic response controlled by EIF2S1-dependent translation that does not require ULK1 activity.
Carcinogenesis
A cell-penetrant lactam-stapled peptide for targeting eIF4E protein-protein interactions.
Carcinogenesis
A functional mTORC1 signaling is indispensable for c-Myc driven hepatocarcinogenesis.
Carcinogenesis
A La-related protein modulates 7SK snRNP integrity to suppress P-TEFb-dependent transcriptional elongation and tumorigenesis.
Carcinogenesis
A novel inhibitor stabilizes the inactive conformation of MAPK-interacting kinase 1.
Carcinogenesis
Aerosol delivery of eukaryotic translation initiation factor 4E-binding protein 1 effectively suppresses lung tumorigenesis in K-rasLA1 mice.
Carcinogenesis
ARHGAP25 Inhibits Pancreatic Adenocarcinoma Growth by Suppressing Glycolysis via AKT/mTOR Pathway.
Carcinogenesis
ARHGAP4 mediates the Warburg effect in pancreatic cancer through the mTOR and HIF-1? signaling pathways.
Carcinogenesis
Associations between genetic variation in RUNX1, RUNX2, RUNX3, MAPK1 and eIF4E and risk of colon and rectal cancer: additional support for a TGF-{beta}-signaling pathway.
Carcinogenesis
Characterization of novel calmodulin binding domains within IQ motifs of IQGAP1.
Carcinogenesis
Cloning of a G-protein-coupled receptor that shows an activity to transform NIH3T3 cells and is expressed in gastric cancer cells.
Carcinogenesis
Combined analysis of eIF4E and 4E-binding protein expression predicts breast cancer survival and estimates eIF4E activity.
Carcinogenesis
Decreasing the level of translation initiation factor 4E with antisense RNA causes reversal of ras-mediated transformation and tumorigenesis of cloned rat embryo fibroblasts.
Carcinogenesis
Different Oligomeric Properties and Stability of Highly Homologous A1 and Proto-Oncogenic A2 Variants of Mammalian Translation Elongation Factor eEF1.
Carcinogenesis
Differential expression of TCEAL1 in esophageal cancers by custom cDNA microarray analysis.
Carcinogenesis
Dimethylation of eEF1A at Lysine 55 Plays a Key Role in the Regulation of eEF1A2 on Malignant Cell Functions of Acute Myeloid Leukemia.
Carcinogenesis
DLC-1, a Rho GTPase-activating protein with tumor suppressor function, is essential for embryonic development.
Carcinogenesis
Effect on the Ras/Raf signaling pathway of post-translational modifications of neurofibromin: In silico study of protein modification responsible for regulatory pathways.
Carcinogenesis
EIF4E over-expresses and enhances cell proliferation and cell cycle progression in nasopharyngeal carcinoma.
Carcinogenesis
eIF4E Threshold Levels Differ in Governing Normal and Neoplastic Expansion of Mammary Stem and Luminal Progenitor Cells.
Carcinogenesis
Elevated expression of eukaryotic translation initiation factor 4E is associated with proliferation, invasion and acquired resistance to erlotinib in lung cancer.
Carcinogenesis
Eukaryotic initiation factor 3C silencing inhibits cell proliferation and promotes apoptosis in human glioma.
Carcinogenesis
Eukaryotic translation initiation factor 3H suppression inhibits osteocarcinoma cell growth and tumorigenesis.
Carcinogenesis
Eukaryotic translation initiation factor 4E induced progression of primary human mammary epithelial cells along the cancer pathway is associated with targeted translational deregulation of oncogenic drivers and inhibitors.
Carcinogenesis
Eukaryotic translation initiation factor 5A2 promotes metabolic reprogramming in hepatocellular carcinoma cells.
Carcinogenesis
Eukaryotic translation initiator protein 1A isoform, CCS-3, enhances the transcriptional repression of p21CIP1 by proto-oncogene FBI-1 (Pokemon/ZBTB7A).
Carcinogenesis
Expression of eukaryotic translation initiation factor 5A-2 (eIF5A-2) associated with poor survival in gastric cancer.
Carcinogenesis
Expression of TBC1D16 Is Associated with Favorable Prognosis of Epithelial Ovarian Cancer.
Carcinogenesis
Expression pattern of EEF1A2 in brain tumors: Histological analysis and functional role as a promoter of EMT.
Carcinogenesis
Expression profile of eukaryotic translation factors in human cancer tissues and cell lines.
Carcinogenesis
Functional role of eukaryotic translation initiation factor 4 gamma 1 (EIF4G1) in NSCLC.
Carcinogenesis
Guanine nucleotides regulate sphingosine kinase 1 activation by eukaryotic elongation factor 1A and provide a mechanism for eEF1A-associated oncogenesis.
Carcinogenesis
Hepatitis B Virus Pre-S2 Mutant Induces Aerobic Glycolysis through Mammalian Target of Rapamycin Signal Cascade.
Carcinogenesis
High expression of eukaryotic initiation factor 3M predicts poor prognosis in colon adenocarcinoma patients.
Carcinogenesis
High intratumoral expression of eIF4A1 promotes epithelial-to-mesenchymal transition and predicts unfavorable prognosis in gastric cancer.
Carcinogenesis
Inappropriate expression of the translation elongation factor 1A disrupts genome stability and metabolism.
Carcinogenesis
Increased expression of stathmin and elongation factor 1? in precancerous nodules with telomere dysfunction in hepatitis B viral cirrhotic patients.
Carcinogenesis
Increased HE4 mRNA Expression Correlates with High Level Of eIF3a mRNA And Better Survival in Women with Epithelial Ovarian Cancer.
Carcinogenesis
Involvement of ERKs, RSK2 and PKR in UVA-induced signal transduction toward phosphorylation of eIF2alpha (Ser(51)).
Carcinogenesis
Involvement of small ArfGAP1 (SMAP1), a novel Arf6-specific GTPase-activating protein, in microsatellite instability oncogenesis.
Carcinogenesis
IQGAP1 silencing suppresses the malignant characteristics of laryngeal squamous cell carcinoma cells.
Carcinogenesis
Knockdown of eIF4E suppresses cell growth and migration, enhances chemosensitivity and correlates with increase in Bax/Bcl-2 ratio in triple-negative breast cancer cells.
Carcinogenesis
Knockdown of IRE1? inhibits colonic tumorigenesis through decreasing ?-catenin and IRE1? targeting suppresses colon cancer cells.
Carcinogenesis
KRAS-Driven Cancers Are Dependent on METTL13-Mediated eEF1A Methylation.
Carcinogenesis
Loss of G3BP1 suppresses proliferation, migration, and invasion of esophageal cancer cells via Wnt/?-catenin and PI3K/AKT signaling pathways.
Carcinogenesis
METTL13 Methylation of eEF1A Increases Translational Output to Promote Tumorigenesis.
Carcinogenesis
miR-939-5p Contributes to the Migration and Invasion of Pancreatic Cancer by Targeting ARHGAP4.
Carcinogenesis
Mitotic protein kinase CDK1 phosphorylation of mRNA translation regulator 4E-BP1 Ser83 may contribute to cell transformation.
Carcinogenesis
Modulation of tumor eIF4E by antisense inhibition: A phase I/II translational clinical trial of ISIS 183750-an antisense oligonucleotide against eIF4E-in combination with irinotecan in solid tumors and irinotecan-refractory colorectal cancer.
Carcinogenesis
Multiple molecular dynamics simulation of the isoforms of human translation elongation factor 1A reveals reversible fluctuations between "open" and "closed" conformations and suggests specific for eEF1A1 affinity for Ca2+-calmodulin.
Carcinogenesis
N6-methyladenosine demethyltransferase FTO-mediated autophagy in malignant development of oral squamous cell carcinoma.
Carcinogenesis
Overexpression of eukaryotic elongation factor eEF2 in gastrointestinal cancers and its involvement in G2/M progression in the cell cycle.
Carcinogenesis
Overexpression of NELFE contributes to gastric cancer progression via Wnt/?-catenin signaling-mediated activation of CSNK2B expression.
Carcinogenesis
Overexpression of the c-myc oncogene inhibits nonsense-mediated RNA decay in B lymphocytes.
Carcinogenesis
Overexpression of the MEN/ELL protein, an RNA polymerase II elongation factor, results in transformation of Rat1 cells with dependence on the lysine-rich region.
Carcinogenesis
p53-dependent translational control of senescence and transformation via 4E-BPs.
Carcinogenesis
Phosphorylation of eEF1A1 at Ser300 by T?R-I results in inhibition of mRNA translation.
Carcinogenesis
Protein phosphatase 2A negatively regulates eukaryotic initiation factor 4E phosphorylation and eIF4F assembly through direct dephosphorylation of Mnk and eIF4E.
Carcinogenesis
Rho GTPase-activating protein 35 rs1052667 polymorphism and osteosarcoma risk and prognosis.
Carcinogenesis
Spectrin Domain of Eukaryotic Initiation Factor 3a Is the Docking Site for Formation of the a:b:i:g Subcomplex.
Carcinogenesis
Structure-activity mapping of ARHGAP36 reveals regulatory roles for its GAP homology and C-terminal domains.
Carcinogenesis
Systematically profiling the expression of eIF3 subunits in glioma reveals the expression of eIF3i has prognostic value in IDH-mutant lower grade glioma.
Carcinogenesis
Targeting the eukaryotic translation initiation factor 4E for cancer therapy.
Carcinogenesis
The eEF1A Proteins: At the Crossroads of Oncogenesis, Apoptosis, and Viral Infections.
Carcinogenesis
The eIF2{alpha} Kinases PERK and PKR Activate Glycogen Synthase Kinase 3 to Promote the Proteasomal Degradation of p53.
Carcinogenesis
The human Y-encoded testis-specific protein interacts functionally with eukaryotic translation elongation factor eEF1A, a putative oncoprotein.
Carcinogenesis
The translation elongation factor 1A in tumorigenesis, signal transduction and apoptosis: review article.
Carcinogenesis
The translation initiation factor eIF3i up-regulates vascular endothelial growth factor A, accelerates cell proliferation, and promotes angiogenesis in embryonic development and tumorigenesis.
Carcinogenesis
Transcription elongation factor SII (TCEA) maps to human chromosome 3p22 --> p21.3.
Carcinogenesis
TUFM-knockdown inhibits the migration and proliferation of gastrointestinal stromal tumor cells.
Carcinogenesis
Upregulation of eukaryotic translation initiation factor 4E associates with a poor prognosis in gallbladder cancer and promotes cell proliferation in vitro and in vivo.
Carcinogenesis
[Expression and its clinical significance of eIF4E in non-small cell lung cancer].
Carcinogenesis
[Expression change of TIF3 p36 at different stages of human bronchial epithelial cells transformed and induced by cadmium chloride]
Carcinoma
A fibroblast elongation factor purified from colon carcinoma cells shares sequence identity with TIMP-1.
Carcinoma
Aberrant expression and phosphorylation of 4E-BP1, a main target of mTOR signaling, in rat mammary carcinomas: an association with etiology.
Carcinoma
Aberrant methylation and deacetylation of deleted in liver cancer-1 gene in prostate cancer: potential clinical applications.
Carcinoma
Carcinoma-associated eIF3i overexpression facilitates mTOR-dependent growth transformation.
Carcinoma
Cell-specific expression of artificial microRNAs targeting essential genes exhibit potent antitumor effect on hepatocellular carcinoma cells.
Carcinoma
Circulatory miR-98-5p levels are deregulated during diabetes and it inhibits proliferation and promotes apoptosis by targeting PPP1R15B in keratinocytes.
Carcinoma
Differential expression of translation-associated genes in benign and malignant human breast tumours.
Carcinoma
Downregulation of IQGAP1 inhibits epithelial-mesenchymal transition via the HIF1?/VEGF-A signaling pathway in gastric cancer.
Carcinoma
EIF3H promotes aggressiveness of esophageal squamous cell carcinoma by modulating Snail stability.
Carcinoma
Elevated eukaryotic elongation factor 2 expression is involved in proliferation and invasion of lung squamous cell carcinoma.
Carcinoma
Eukaryotic polypeptide elongation system and its sensitivity to the inhibitory substances of plant origin.
Carcinoma
Eukaryotic translation elongation factor 1?, N-terminal propeptide of type I collagen and cancer-associated fibroblasts are prognostic markers of oral squamous cell carcinoma patients.
Carcinoma
Eukaryotic translation initiation factor 3B accelerates the progression of esophageal squamous cell carcinoma by activating ?-catenin signaling pathway.
Carcinoma
Eukaryotic Translation Initiation Factor 3b is both a Promising Prognostic Biomarker and a Potential Therapeutic Target for Patients with Clear Cell Renal Cell Carcinoma.
Carcinoma
Eukaryotic translation initiation factor 5A-2 involves in doxorubicin-induced epithelial-mesenchymal transition in oral squamous cell carcinoma cells.
Carcinoma
Eukaryotic translation initiation factor EIF3H potentiates gastric carcinoma cell proliferation.
Carcinoma
Farnesyltransferase inhibitor SCH66336 induces rapid phosphorylation of eukaryotic translation elongation factor 2 in head and neck squamous cell carcinoma cells.
Carcinoma
FilGAP, a Rho/Rho-associated protein kinase-regulated GTPase-activating protein for Rac, controls tumor cell migration.
Carcinoma
Growth factor-independent expression of the gene encoding eukaryotic translation initiation factor 4E in transformed cell lines.
Carcinoma
Growth inhibition of head and neck squamous carcinoma cells by small interfering RNAs targeting eIF4E or cyclin D1 alone or combined with cisplatin.
Carcinoma
Growth stimulation and induction of epidermal growth factor receptor by overexpression of cyclooxygenases 1 and 2 in human colon carcinoma cells.
Carcinoma
High EIF4E2 expression is an independent prognostic risk factor for poor overall survival and recurrence-free survival in uveal melanoma.
Carcinoma
High eukaryotic translation elongation factor 1 alpha 1 expression promotes proliferation and predicts poor prognosis in clear cell renal cell carcinoma.
Carcinoma
High hydrostatic pressure inhibits the biosynthesis of eukaryotic elongation factor-2.
Carcinoma
Human breast cancer cells contain elevated levels and activity of the protein kinase, PKR.
Carcinoma
Human prostatic carcinoma oncogene PTI-1 is expressed in human tumor cell lines and prostate carcinoma patient blood samples.
Carcinoma
In Preclinical Model of Ovarian Cancer, the SGK1 Inhibitor SI113 Counteracts the Development of Paclitaxel Resistance and Restores Drug Sensitivity.
Carcinoma
In vitro and in vivo characterization of a dual-function green fluorescent protein--HSV1-thymidine kinase reporter gene driven by the human elongation factor 1 alpha promoter.
Carcinoma
Inhibition of eIF4E cooperates with chemotherapy and immunotherapy in renal cell carcinoma.
Carcinoma
Inhibition of phosphatidylinositol 3-kinase- and ERK MAPK-regulated protein synthesis reveals the pro-apoptotic properties of CD40 ligation in carcinoma cells.
Carcinoma
Interactome Mapping of eIF3A in a Colon Cancer and an Immortalized Embryonic Cell Line Using Proximity-Dependent Biotin Identification.
Carcinoma
Isolation and properties of the subunit form EF-1C of elongation factor 1 from Guerin epithelioma cells.
Carcinoma
Levels, phosphorylation status and cellular localization of translational factor eIF2 in gastrointestinal carcinomas.
Carcinoma
Loss of DLC1 is an independent prognostic factor in patients with oral squamous cell carcinoma.
Carcinoma
MDM2 is Overexpressed and Regulated by the Eukaryotic Translation Initiation Factor 4E (eIF4E) in Human Squamous Cell Carcinoma of Esophagus.
Carcinoma
MicroRNA-216a inhibits the growth and metastasis of oral squamous cell carcinoma by targeting eukaryotic translation initiation factor 4B.
Carcinoma
Monoclonal antibodies to elongation factor-1alpha inhibit in vitro translation in lysates of Sf21 cells.
Carcinoma
N6-methyladenosine demethyltransferase FTO-mediated autophagy in malignant development of oral squamous cell carcinoma.
Carcinoma
Oncogenic Role of an Epigenetic Reader of m6A RNA Modification: YTHDF1 in Merkel Cell Carcinoma.
Carcinoma
Overexpression of the eukaryotic translation initiation factor 4G (eIF4G-1) in squamous cell lung carcinoma.
Carcinoma
Preclinical evidence that MNK/eIF4E inhibition by cercosporamide enhances the response to antiangiogenic TKI and mTOR inhibitor in renal cell carcinoma.
Carcinoma
Proteome of Metastatic Canine Mammary Carcinomas: Similarities to and Differences from Human Breast Cancer ().
Carcinoma
Purification and properties of the heterogeneous subunits of elongation factor EF-1 from Guerin epithelioma cells.
Carcinoma
Rac GTPase-Activating Protein 1 (RACGAP1) as an Oncogenic Enhancer in Esophageal Carcinoma.
Carcinoma
Regulation of Cited2 expression provides a functional link between translational and transcriptional responses during hypoxia.
Carcinoma
The eIF3a Arg803Lys genetic polymorphism is associated with susceptibility to and chemoradiotherapy efficacy in cervical carcinoma.
Carcinoma
The eukaryotic translation elongation factor eEF1A2 induces neoplastic properties and mediates tumorigenic effects of ZNF217 in precursor cells of human ovarian carcinomas.
Carcinoma
The value of histomorphometric nuclear parameters in the diagnosis of well differentiated follicular carcinomas and follicular adenomas of the thyroid gland.
Carcinoma
Translation initiation factor eIF-4G is immunogenic, overexpressed, and amplified in patients with squamous cell lung carcinoma.
Carcinoma
Translation initiation factor eIF-4gamma is encoded by an amplified gene and induces an immune response in squamous cell lung carcinoma.
Carcinoma
Translational control in the stress adaptive response of cancer cells: a novel role for the heat shock protein TRAP1.
Carcinoma
Tumor Suppression of Ras GTPase-Activating Protein RASA5 through Antagonizing Ras Signaling Perturbation in Carcinomas.
Carcinoma
[Correlation between prognosis and the expression of eukaryotic translation initiation factor 4E in surgical margin specimen of laryngeal squamous cell carcinoma]
Carcinoma, Ductal
IQ-domain GTPase-activating protein 1 promotes the malignant phenotype of invasive ductal breast carcinoma via canonical Wnt pathway.
Carcinoma, Ehrlich Tumor
A GDP/GTP exchange factor essential for eukaryotic initiation factor 2 cycling in Ehrlich ascites tumor cells and its regulation by eukaryotic initiation factor 2 phosphorylation.
Carcinoma, Ehrlich Tumor
Differential phosphorylation of soluble versus ribosome-bound eukaryotic initiation factor 2 in the Ehrlich ascites tumor cell.
Carcinoma, Ehrlich Tumor
Increased activity of the eEF-2 specific, Ca2+ and calmodulin dependent protein kinase III during the S-phase in Ehrlich ascites cells.
Carcinoma, Hepatocellular
Activation of protein kinase C stimulates the tyrosine phosphorylation and guanosine triphosphatase-activating protein association of p60 in rat hepatoma cells.
Carcinoma, Hepatocellular
ASAP3 is a downstream target of HIF-1? and is critical for progression of lung adenocarcinoma.
Carcinoma, Hepatocellular
ASAP3 is a focal adhesion-associated Arf GAP that functions in cell migration and invasion.
Carcinoma, Hepatocellular
Autoantibody response to Sui1 and its tissue-specific expression in hepatocellular carcinoma.
Carcinoma, Hepatocellular
CHOP favors endoplasmic reticulum stress-induced apoptosis in hepatocellular carcinoma cells via inhibition of autophagy.
Carcinoma, Hepatocellular
Circulatory miR-98-5p levels are deregulated during diabetes and it inhibits proliferation and promotes apoptosis by targeting PPP1R15B in keratinocytes.
Carcinoma, Hepatocellular
Deleted in Liver Cancer 1 (DLC1) Utilizes a Novel Binding Site for Tensin2 PTB Domain Interaction and Is Required for Tumor-Suppressive Function.
Carcinoma, Hepatocellular
Deleted in liver cancer 2 (DLC2) was dispensable for development and its deficiency did not aggravate hepatocarcinogenesis.
Carcinoma, Hepatocellular
Detection of eukaryotic translation initiation factor 4E and its clinical significance in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Dissecting the role of the elongation factor 1A isoforms in hepatocellular carcinoma cells by liposome-mediated delivery of siRNAs.
Carcinoma, Hepatocellular
DLC-1, a GTPase-activating protein for Rho, is associated with cell proliferation, morphology, and migration in human hepatocellular carcinoma.
Carcinoma, Hepatocellular
eIF-2 initiation factor activity in Yoshida ascites hepatoma AH 130 cells and in 4-dimethylaminoazobenzene-induced liver tumor tissue during growth.
Carcinoma, Hepatocellular
Elevated expression of eukaryotic translation initiation factor 3H is associated with proliferation, invasion and tumorigenicity in human hepatocellular carcinoma.
Carcinoma, Hepatocellular
Erythropoietin enhancer stimulates production of a recombinant protein by Chinese hamster ovary (CHO) cells under hypoxic condition.
Carcinoma, Hepatocellular
Eukaryotic elongation factor-1? 2 knockdown inhibits hepatocarcinogenesis by suppressing PI3K/Akt/NF-?B signaling.
Carcinoma, Hepatocellular
Eukaryotic initiation factor 2-associated glycoprotein, p67, shows differential effects on the activity of certain kinases during serum-starved conditions.
Carcinoma, Hepatocellular
Eukaryotic translation initiation factor 5A2 promotes metabolic reprogramming in hepatocellular carcinoma cells.
Carcinoma, Hepatocellular
Eukaryotic translation initiation factor 5A2 regulates the migration and invasion of hepatocellular carcinoma cells via pathways involving reactive oxygen species.
Carcinoma, Hepatocellular
Hepatitis B virus X protein blocks filamentous actin bundles by interaction with eukaryotic translation elongat ion factor 1 alpha 1.
Carcinoma, Hepatocellular
Hepatitis C virus IRES-dependent translation is insensitive to an eIF2alpha-independent mechanism of inhibition by interferon in hepatocyte cell lines.
Carcinoma, Hepatocellular
Implications of the Use of Eukaryotic Translation Initiation Factor 5A (eIF5A) for Prognosis and Treatment of Hepatocellular Carcinoma.
Carcinoma, Hepatocellular
Inactivation of eIF2B and phosphorylation of PHAS-I in heat-shocked rat hepatoma cells.
Carcinoma, Hepatocellular
Inhibition of eIF2? dephosphorylation enhances TRAIL-induced apoptosis in hepatoma cells.
Carcinoma, Hepatocellular
Inhibition of eukaryotic elongation factor-2 confers to tumor suppression by a herbal formulation Huanglian-Jiedu decoction in human hepatocellular carcinoma.
Carcinoma, Hepatocellular
Knockdown of eukaryotic translation initiation factor 5A2 enhances the therapeutic efficiency of doxorubicin in hepatocellular carcinoma cells by triggering lethal autophagy.
Carcinoma, Hepatocellular
Low expression of DAB2IP contributes to malignant development and poor prognosis in hepatocellular carcinoma.
Carcinoma, Hepatocellular
MEK Signaling Is Required for Phosphorylation of eIF2{alpha} following Amino Acid Limitation of HepG2 Human Hepatoma Cells.
Carcinoma, Hepatocellular
MicroRNA-383 inhibits doxorubicin resistance in hepatocellular carcinoma by targeting eukaryotic translation initiation factor 5A2.
Carcinoma, Hepatocellular
MicroRNA-9 enhances sensitivity to cetuximab in epithelial phenotype hepatocellular carcinoma cells through regulation of the eukaryotic translation initiation factor 5A-2.
Carcinoma, Hepatocellular
MicroRNA?875?5p inhibits tumor growth and metastasis of hepatocellular carcinoma by targeting eukaryotic translation initiation factor 3 subunit a.
Carcinoma, Hepatocellular
N1-guanyl-1,7-diaminoheptane (GC7) enhances the therapeutic efficacy of doxorubicin by inhibiting activation of eukaryotic translation initiation factor 5A2 (eIF5A2) and preventing the epithelial-mesenchymal transition in hepatocellular carcinoma cells.
Carcinoma, Hepatocellular
Opposing roles of C/EBP? and eEF1A1 in Sp1-regulated miR-122 transcription.
Carcinoma, Hepatocellular
Overexpressed-eIF3I interacted and activated oncogenic Akt1 is a theranostic target in human hepatocellular carcinoma.
Carcinoma, Hepatocellular
PKR protein kinase is activated by hepatitis C virus and inhibits viral replication through translational control.
Carcinoma, Hepatocellular
Prognostic significance and therapeutic potential of eukaryotic translation initiation factor 5A (eIF5A) in hepatocellular carcinoma.
Carcinoma, Hepatocellular
RanBP1 controls the Ran pathway in mammalian cells through regulation of mitotic RCC1 dynamics.
Carcinoma, Hepatocellular
Rho GTPase-activating protein deleted in liver cancer suppresses cell proliferation and invasion in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Suppression of Vascular Endothelial Growth Factor via Inactivation of Eukaryotic Elongation Factor 2 by Alkaloids in Coptidis rhizoma in Hepatocellular Carcinoma.
Carcinoma, Hepatocellular
The expression levels of the translational factors eEF1A 1/2 correlate with cell growth but not apoptosis in hepatocellular carcinoma cell lines with different differentiation grade.
Carcinoma, Hepatocellular
The intracellular stability of DLC1 is regulated by the 26S proteasome in human hepatocellular carcinoma cell line Hep3B.
Carcinoma, Hepatocellular
The translation initiation factor eIF3i up-regulates vascular endothelial growth factor A, accelerates cell proliferation, and promotes angiogenesis in embryonic development and tumorigenesis.
Carcinoma, Hepatocellular
Up-regulation of Rac GTPase activating protein 1 is significantly associated with the early recurrence of human hepatocellular carcinoma.
Carcinoma, Hepatocellular
[Eukaryotic translation elongation factor 1A1 positively regulates NOB1 expression to promote invasion and metastasis of hepatocellular carcinoma cells in vitro].
Carcinoma, Intraductal, Noninfiltrating
Autoantibodies to Annexin XI-A and Other Autoantigens in the Diagnosis of Breast Cancer.
Carcinoma, Merkel Cell
Oncogenic Role of an Epigenetic Reader of m6A RNA Modification: YTHDF1 in Merkel Cell Carcinoma.
Carcinoma, Non-Small-Cell Lung
CGP57380 enhances efficacy of RAD001 in non-small cell lung cancer through abrogating mTOR inhibition-induced phosphorylation of eIF4E and activating mitochondrial apoptotic pathway.
Carcinoma, Non-Small-Cell Lung
Cisplatin sensitivity is enhanced in non-small cell lung cancer cells by regulating epithelial-mesenchymal transition through inhibition of eukaryotic translation initiation factor 5A2.
Carcinoma, Non-Small-Cell Lung
Clinical value of eukaryotic elongation factor 2 (eEF2) in non-small cell lung cancer patients.
Carcinoma, Non-Small-Cell Lung
Coexpression of IQ-domain GTPase-activating protein 1 (IQGAP1) and Dishevelled (Dvl) is correlated with poor prognosis in non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
CRL4A-FBXW5-mediated degradation of DLC1 Rho GTPase-activating protein tumor suppressor promotes non-small cell lung cancer cell growth.
Carcinoma, Non-Small-Cell Lung
Eukaryotic translation initiation factor 3 subunit C is associated with acquired resistance to erlotinib in non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Influence of eukaryotic translation initiation factor 6 on non-small cell lung cancer development and progression.
Carcinoma, Non-Small-Cell Lung
MicroRNA-9 Enhanced Cisplatin Sensitivity in Nonsmall Cell Lung Cancer Cells by Regulating Eukaryotic Translation Initiation Factor 5A2.
Carcinoma, Non-Small-Cell Lung
MicroRNA-9 regulates non-small cell lung cancer cell invasion and migration by targeting eukaryotic translation initiation factor 5A2.
Carcinoma, Non-Small-Cell Lung
MYC and EIF3H Coamplification significantly improve response and survival of non-small cell lung cancer patients (NSCLC) treated with gefitinib.
Carcinoma, Non-Small-Cell Lung
N1-guanyl-1,7-diaminoheptane enhances the chemosensitivity of NSCLC cells to cetuximab through inhibition of eukaryotic translation initiation factor 5A2 activation.
Carcinoma, Non-Small-Cell Lung
The anti-cancer drug ABTL0812 induces ER stress-mediated cytotoxic autophagy by increasing dihydroceramide levels in cancer cells.
Carcinoma, Non-Small-Cell Lung
The expression of eukaryotic translation initiation factor 3B and its correlation with tumor characteristics as well as prognosis in non-small cell lung cancer patients: a retrospective study.
Carcinoma, Non-Small-Cell Lung
The prognostic significance of eukaryotic elongation factor 1 alpha-2 in non-small cell lung cancer.
Carcinoma, Ovarian Epithelial
Polymorphisms in TCEAL7 and risk of epithelial ovarian cancer.
Carcinoma, Ovarian Epithelial
The eukaryotic translation elongation factor eEF1A2 induces neoplastic properties and mediates tumorigenic effects of ZNF217 in precursor cells of human ovarian carcinomas.
Carcinoma, Renal Cell
Eukaryotic Translation Initiation Factor 3b is both a Promising Prognostic Biomarker and a Potential Therapeutic Target for Patients with Clear Cell Renal Cell Carcinoma.
Carcinoma, Renal Cell
High eukaryotic translation elongation factor 1 alpha 1 expression promotes proliferation and predicts poor prognosis in clear cell renal cell carcinoma.
Carcinoma, Renal Cell
Inhibition of eIF4E cooperates with chemotherapy and immunotherapy in renal cell carcinoma.
Carcinoma, Renal Cell
Preclinical evidence that MNK/eIF4E inhibition by cercosporamide enhances the response to antiangiogenic TKI and mTOR inhibitor in renal cell carcinoma.
Carcinoma, Squamous Cell
Comparative proteomic analysis of esophageal squamous cell carcinoma.
Carcinoma, Squamous Cell
Elevated eukaryotic elongation factor 2 expression is involved in proliferation and invasion of lung squamous cell carcinoma.
Carcinoma, Squamous Cell
Epidermal growth factor stimulates substrate-selective protein-tyrosine-phosphatase activity.
Carcinoma, Squamous Cell
Farnesyltransferase inhibitor SCH66336 induces rapid phosphorylation of eukaryotic translation elongation factor 2 in head and neck squamous cell carcinoma cells.
Carcinoma, Squamous Cell
Growth inhibition of head and neck squamous carcinoma cells by small interfering RNAs targeting eIF4E or cyclin D1 alone or combined with cisplatin.
Carcinoma, Squamous Cell
MDM2 is Overexpressed and Regulated by the Eukaryotic Translation Initiation Factor 4E (eIF4E) in Human Squamous Cell Carcinoma of Esophagus.
Carcinoma, Squamous Cell
The role of eukaryotic translation initiation factor 5A-1 (eIF5A-1) gene in HPV 16 E6 induces cell growth in human cervical squamous carcinoma cells.
Carcinosarcoma
RNA-seq Identification of RACGAP1 as a Metastatic Driver in Uterine Carcinosarcoma.
Cardiomegaly
Pivotal role of cardiac lineage protein-1 (CLP-1) in transcriptional elongation factor P-TEFb complex formation in cardiac hypertrophy.
Cardiomegaly
The impact of insulin-like growth factor-1 on the pattern of cardiac elongation factor-2 variants in a model of overload.
Cardiomyopathies
Mitochondrial EFTs defects in juvenile-onset Leigh disease, ataxia, neuropathy, and optic atrophy.
Cardiomyopathies
Novel compound mutations in the mitochondrial translation elongation factor (TSFM) gene cause severe cardiomyopathy with myocardial fibro-adipose replacement.
Cardiomyopathy, Dilated
MTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice.
Cardiomyopathy, Hypertrophic
Molecular-genetic characterization and rescue of a TSFM mutation causing childhood-onset ataxia and nonobstructive cardiomyopathy.
Cardiovascular Diseases
Neuroprotection Mediated by Upregulation of Endothelial Nitric Oxide Synthase in Rho-Associated, Coiled-Coil-Containing Kinase 2 Deficient Mice.
Cerebellar Ataxia
From dizziness to severe ataxia and dysarthria: New cases of anti-Ca/ARHGAP26 autoantibody-associated cerebellar ataxia suggest a broad clinical spectrum.
Cerebellar Ataxia
Psychotic syndrome associated with anti-Ca/ARHGAP26 and voltage-gated potassium channel antibodies.
Cholangiocarcinoma
Translational regulation of x-linked inhibitor of apoptosis protein by interleukin-6: a novel mechanism of tumor cell survival.
Cholera
Transport of the cholera toxin B-subunit from recycling endosomes to the Golgi requires clathrin and AP-1.
Choriocarcinoma
A protein kinase C-independent pathway leading to c-Jun-dependent expression of 100-kDa Ras GTPase-activating protein in JEG-3 human choriocarcinoma cells.
Classical Swine Fever
eEF1A Interacts with the NS5A Protein and Inhibits the Growth of Classical Swine Fever Virus.
Classical Swine Fever
eIF2-dependent and eIF2-independent modes of initiation on the CSFV IRES: a common role of domain II.
Classical Swine Fever
Specific interaction of eukaryotic translation initiation factor 3 with the 5' nontranslated regions of hepatitis C virus and classical swine fever virus RNAs.
Classical Swine Fever
The eukaryotic translation initiation factor 3 subunit E binds to classical swine fever virus NS5A and facilitates viral replication.
Cleft Lip
Protein Macroarray Profiling of Serum Autoantibodies in Pseudoexfoliation Glaucoma.
Clostridium Infections
Identification and cloning of two immunogenic Clostridium perfringens proteins, elongation factor Tu (EF-Tu) and pyruvate:ferredoxin oxidoreductase (PFO) of C. perfringens.
Cockayne Syndrome
A compromised yeast RNA polymerase II enhances UV sensitivity in the absence of global genome nucleotide excision repair.
Cockayne Syndrome
Transcription elongation factor Spt4 mediates loss of phosphorylated RNA polymerase II transcription in response to DNA damage.
Coinfection
Activation of dsRNA Dependent Protein Kinase PKR in Karpas299 Does Not Lead to Cell Death.
Colitis
DNA microarray technology reveals similar gene expression patterns in rats with vitamin a deficiency and chemically induced colitis.
Colitis
Induction of dsRNA-activated protein kinase links mitochondrial unfolded protein response to the pathogenesis of intestinal inflammation.
Colitis
Regulation of transient receptor potential cation channel subfamily V1 protein synthesis by the phosphoinositide 3-kinase/Akt pathway in colonic hypersensitivity.
Colitis
The GTPase-activating protein GIT2 protects against colitis by negatively regulating Toll-like receptor signaling.
Colitis, Ulcerative
New insights into the interplay between autophagy, gut microbiota and inflammatory responses in IBD.
Colonic Neoplasms
Eukaryotic translation initiation factor 5A induces apoptosis in colon cancer cells and associates with the nucleus in response to tumour necrosis factor alpha signalling.
Colonic Neoplasms
Expression of EEF1A1 Is Associated with Prognosis of Patients with Colon Adenocarcinoma.
Colonic Neoplasms
Expression profile of eukaryotic translation factors in human cancer tissues and cell lines.
Colonic Neoplasms
Integrative Analysis of the IQ Motif-Containing GTPase-Activating Protein Family Indicates That the IQGAP3-PIK3C2B Axis Promotes Invasion in Colon Cancer.
Colonic Neoplasms
Lentivirus-mediated knockdown of eukaryotic translation initiation factor 3 subunit D inhibits proliferation of HCT116 colon cancer cells.
Colonic Neoplasms
Muscarinic acetylcholine receptors regulate the dephosphorylation of eukaryotic translation elongation factor 2 in SNU-407 colon cancer cells.
Colonic Neoplasms
Nannocystin ax, an eEF1A inhibitor, induces G1 cell cycle arrest and caspase-independent apoptosis through cyclin D1 downregulation in colon cancer in vivo.
Colonic Neoplasms
Overexpression of p150, a part of the large subunit of the eukaryotic translation initiation factor 3, in colon cancer.
Colonic Neoplasms
Overexpression of ribosomal proteins L4 and L5 and the putative alternative elongation factor PTI-1 in the doxorubicin resistant human colon cancer cell line LoVoDxR.
Colonic Neoplasms
RNA interference-mediated silencing of eukaryotic translation initiation factor 3, subunit B (EIF3B) gene expression inhibits proliferation of colon cancer cells.
Colonic Neoplasms
Silencing of EEF2K (eukaryotic elongation factor-2 kinase) reveals AMPK-ULK1-dependent autophagy in colon cancer cells.
Colorectal Neoplasms
A MYC-GCN2-eIF2? negative feedback loop limits protein synthesis to prevent MYC-dependent apoptosis in colorectal cancer.
Colorectal Neoplasms
ARHGAP24 regulates cell ability and apoptosis of colorectal cancer cells via the regulation of P53.
Colorectal Neoplasms
Commitment of Scaffold Proteins in the Onco-Biology of Human Colorectal Cancer and Liver Metastases after Oxaliplatin-Based Chemotherapy.
Colorectal Neoplasms
Eukaryotic initiation factor-2, gamma subunit, suppresses proliferation and regulates the cell cycle via the MAPK/ERK signaling pathway in acute myeloid leukemia.
Colorectal Neoplasms
Eukaryotic translation initiation factor 3 subunit G promotes human colorectal cancer.
Colorectal Neoplasms
Eukaryotic translation initiation factor 5A2 (eIF5A2) regulates chemoresistance in colorectal cancer through epithelial mesenchymal transition.
Colorectal Neoplasms
Expression and clinicopathologic significance of TUFM and p53 for the normal-adenoma-carcinoma sequence in colorectal epithelia.
Colorectal Neoplasms
High WBP5 expression correlates with elevation of HOX genes levels and is associated with inferior survival in patients with acute myeloid leukaemia.
Colorectal Neoplasms
Impact of genetic variations in the MAPK signaling pathway on outcome in metastatic colorectal cancer patients treated with first-line FOLFIRI and bevacizumab: data from FIRE-3 and TRIBE trials.
Colorectal Neoplasms
Inhibition of eIF2alpha dephosphorylation inhibits ErbB2-induced deregulation of mammary acinar morphogenesis.
Colorectal Neoplasms
Involvement of small ArfGAP1 (SMAP1), a novel Arf6-specific GTPase-activating protein, in microsatellite instability oncogenesis.
Colorectal Neoplasms
miR-133a acts as a tumor suppressor in colorectal cancer by targeting eIF4A1.
Colorectal Neoplasms
Overexpression of NELFCD promotes colorectal cancer cells proliferation, migration, and invasion.
Colorectal Neoplasms
Phenethyl isothiocyanate, a cancer chemopreventive constituent of cruciferous vegetables, inhibits cap-dependent translation by regulating the level and phosphorylation of 4E-BP1.
Colorectal Neoplasms
Ribavirin inhibits colorectal cancer growth by downregulating PRMT5 expression and H3R8me2s and H4R3me2s accumulation.
Colorectal Neoplasms
The downregulation of Rap1 GTPase-activating protein is associated with a poor prognosis in colorectal cancer and may impact on tumor progression.
Colorectal Neoplasms
The overexpression of elongation factor 1 gamma mRNA in gastric carcinoma.
Colorectal Neoplasms
Translational control in the stress adaptive response of cancer cells: a novel role for the heat shock protein TRAP1.
Colorectal Neoplasms
Ubiquitin specific peptidase 5 regulates colorectal cancer cell growth by stabilizing Tu translation elongation factor.
Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Rac1 mediates the osteoclast gains-in-function induced by haploinsufficiency of Nf1.
Coronavirus Infections
COVID-19 and Inflammatory Bowel Diseases: Risk Assessment, Shared Molecular Pathways, and Therapeutic Challenges.
Crohn Disease
New insights into the interplay between autophagy, gut microbiota and inflammatory responses in IBD.
Crohn Disease
T-cell activation Rho GTPase-activating protein expression varies with inflammation location and severity in Crohn's disease.
Cystic Fibrosis
Global reprogramming of virulence and antibiotic resistance in Pseudomonas aeruginosa by a single nucleotide polymorphism in elongation factor, fusA1.
Cysts
Cyst morphology and sequence analysis of the small subunit rDNA and ef1 alpha identifies a novel Giardia genotype in a quenda (Isoodon obesulus) from Western Australia.
Cysts
Distribution of the low molecular weight form of eukaryotic elongation factor 1 in various tissues.
Cysts
Elongation factor 1 beta gamma from Artemia. Purification and properties of its subunits.
Cysts
Molecular cloning and analysis of cDNA sequences for two ribosomal proteins from Artemia. The coordinate expression of genes for ribosomal proteins and elongation factor 1 during embryogenesis of Artemia.
Cysts
Sequence homology between EF-1 alpha, the alpha-chain of elongation factor 1 from Artemia salina and elongation factor EF-Tu from Escherichia coli.
Cysts
TgIF2K-B Is an eIF2? Kinase in Toxoplasma gondii That Responds to Oxidative Stress and Optimizes Pathogenicity.
Cysts
The role of guanine nucleotides in the interaction between aminoacyl-tRNA and elongation factor 1 of Artemia salina.
Cysts
Translation regulation by eukaryotic initiation factor-2 kinases in the development of latent cysts in Toxoplasma gondii.
Dehydration
Expression analysis of genes encoding translation initiation factor 3 subunit g (TaeIF3g) and vesicle-associated membrane protein-associated protein (TaVAP) in drought tolerant and susceptible cultivars of wheat
Dehydration
Selection of Reference Genes for qRT-PCR Analysis in Medicinal Plant Glycyrrhiza under Abiotic Stresses and Hormonal Treatments.
Dementia
Sequence variants in eukaryotic translation initiation factor 4-gamma (eIF4G1) are associated with Lewy body dementia.
Demyelinating Diseases
Poor cerebral inflammatory response in eIF2B knock-in mice: implications for the aetiology of vanishing white matter disease.
Dengue
Interaction between the cellular protein eEF1A and the 3'-terminal stem-loop of West Nile virus genomic RNA facilitates viral minus-strand RNA synthesis.
Dengue
Translation elongation factor-1alpha, La, and PTB interact with the 3' untranslated region of dengue 4 virus RNA.
Dengue
Upregulation of a novel eukaryotic translation initiation factor 5A (eIF5A) in dengue 2 virus-infected mosquito cells.
Diabetes Mellitus
Podocyte hypertrophy precedes apoptosis under experimental diabetic conditions.
Diabetes Mellitus
The Level of Autoantibodies Targeting Eukaryote Translation Elongation Factor 1 ?1 and Ubiquitin-Conjugating Enzyme 2L3 in Nondiabetic Young Adults.
Diabetes Mellitus
Unbalanced expression of the different subunits of elongation factor 1 in diabetic skeletal muscle.
Diabetes Mellitus, Type 1
Eukaryotic translation initiation factor 5A inhibition alters physiopathology and immune responses in a "humanized" transgenic mouse model of type 1 diabetes.
Diabetes Mellitus, Type 1
Microcephaly and simplified gyral pattern of the brain associated with early onset insulin-dependent diabetes mellitus.
Diabetes Mellitus, Type 1
The Level of Autoantibodies Targeting Eukaryote Translation Elongation Factor 1 ?1 and Ubiquitin-Conjugating Enzyme 2L3 in Nondiabetic Young Adults.
Diabetes Mellitus, Type 2
A self-defeating anabolic program leads to ?-cell apoptosis in endoplasmic reticulum stress-induced diabetes via regulation of amino acid flux.
Diabetes Mellitus, Type 2
DBC1, p300, HDAC3, and Siah1 coordinately regulate ELL stability and function for expression of its target genes.
Diabetes Mellitus, Type 2
EIF4A2 Is a Positional Candidate Gene at the 3q27 Locus Linked to Type 2 Diabetes in French Families.
Diabetes Mellitus, Type 2
Reciprocal regulation of mTOR complexes in pancreatic islets from humans with type 2 diabetes.
Diabetes Mellitus, Type 2
Selective inhibition of eukaryotic translation initiation factor 2 alpha dephosphorylation potentiates fatty acid-induced endoplasmic reticulum stress and causes pancreatic beta-cell dysfunction and apoptosis.
Diabetes Mellitus, Type 2
Unbalanced expression of the different subunits of elongation factor 1 in diabetic skeletal muscle.
Diabetic Nephropathies
Cluster analysis and phylogenetic relationship in biomarker identification of type 2 diabetes and nephropathy.
Diabetic Nephropathies
MicroRNA-23b Targets Ras GTPase-Activating Protein SH3 Domain-Binding Protein 2 to Alleviate Fibrosis and Albuminuria in Diabetic Nephropathy.
Diphtheria
A dominant-negative approach that prevents diphthamide formation confers resistance to Pseudomonas exotoxin a and diphtheria toxin.
Diphtheria
A versatile partner of eukaryotic protein complexes that is involved in multiple biological processes: Kti11/Dph3.
Diphtheria
ADP-ribosylatable content of elongation factor-2 changes during cell cycle of normal and cancerous human cells.
Diphtheria
ADP-ribosylation of Translation Elongation Factor 2 by Diphtheria Toxin in Yeast Inhibits Translation and Cell Separation.
Diphtheria
ADP-ribosyltransferase from beef liver which ADP-ribosylates elongation factor-2.
Diphtheria
An Entamoeba histolytica ADP-ribosyl transferase from the diphtheria toxin family modifies the bacterial elongation factor Tu.
Diphtheria
Comparison of the frequency of diphtheria toxin and thioguanine resistance induced by a series of carcinogens to analyze their mutational specificities in diploid human fibroblasts.
Diphtheria
Cytotoxic properties of DAB486EGF and DAB389EGF, epidermal growth factor (EGF) receptor-targeted fusion toxins.
Diphtheria
Denileukin diftitox: a biotherapeutic paradigm shift in the treatment of lymphoid-derived disorders.
Diphtheria
Diphthamide biosynthesis requires an organic radical generated by an iron-sulphur enzyme.
Diphtheria
Diphthamide modification of eEF2 requires a J-domain protein and is essential for normal development.
Diphtheria
Diphtheria toxin mutant CRM197 is an inhibitor of protein synthesis that induces cellular toxicity.
Diphtheria
Diphtheria toxin- and Pseudomonas A toxin-mediated apoptosis. ADP ribosylation of elongation factor-2 is required for DNA fragmentation and cell lysis and synergy with tumor necrosis factor-alpha.
Diphtheria
Diphtheria toxin. Site and configuration of ADP-ribosylation of diphthamide in elongation factor 2.
Diphtheria
Diphtheria-toxin-resistant mutants of CHO cells affected in protein synthesis: a novel phenotype.
Diphtheria
Dph3 is an electron donor for Dph1-Dph2 in the first step of eukaryotic diphthamide biosynthesis.
Diphtheria
Dph3, a small protein required for diphthamide biosynthesis, is essential in mouse development.
Diphtheria
Effect of gangliosides and substrate analogues on the hydrolysis of nicotinamide adenine dinucleotide by choleragen.
Diphtheria
Endogenous ADP-ribosylation for eukaryotic elongation factor 2: evidence of two different sites and reactions.
Diphtheria
Endogenous ADP-ribosylation of eukaryotic elongation factor 2 and its 32 kDa tryptic fragment.
Diphtheria
Entry of diphtheria toxin into cells: possible existence of cellular factor(s) for entry of diphtheria toxin into cells was studied in somatic cell hybrids and hybrid toxins.
Diphtheria
Estimating the amounts of ADP-ribosylatable active elongation factor-2 in mammalian cell-free extracts.
Diphtheria
Expression of a biologically active diphtheria toxin fragment B in Escherichia coli.
Diphtheria
Gene for the diphtheria toxin-susceptible elongation factor 2 from Methanococcus vannielii.
Diphtheria
Identification of the proteins required for biosynthesis of diphthamide, the target of bacterial ADP-ribosylating toxins on translation elongation factor 2.
Diphtheria
Inhibition of metabolic cooperation by phorbol esters in a cell culture system based on adenosine kinase deficient mutants of V79 cells.
Diphtheria
Loss of diphthamide pre-activates NF-?B and death receptor pathways and renders MCF7 cells hypersensitive to tumor necrosis factor.
Diphtheria
Mechanistic understanding of Pyrococcus horikoshii Dph2, a [4Fe-4S] enzyme required for diphthamide biosynthesis.
Diphtheria
Modulation of diphthamide synthesis by 5'-deoxy-5'-methylthioadenosine in murine lymphoma cells.
Diphtheria
Novel cholix toxin variants, ADP-ribosylating toxins in Vibrio cholerae non-O1/non-O139 strains, and their pathogenicity.
Diphtheria
On diphtheria toxin fragment A release into the cytosol-Cytochalasin D effect and involvement of actin filaments and eukaryotic elongation factor 2.
Diphtheria
Pseudomonas aeruginosa exoenzyme S: an adenosine diphosphate ribosyltransferase distinct from toxin A.
Diphtheria
Receptor-mediated transport of the hybrid protein ricin-diphtheria toxin fragment A with subsequent ADP-ribosylation of intracellular elongation factor II.
Diphtheria
Reduced levels of ADP-ribosylatable elongation factor-2 in aged and SV40-transformed human cell cultures.
Diphtheria
Role of CypA and Hsp90 in membrane translocation mediated by anthrax Protective Antigen.
Diphtheria
Site-specific mutagenesis of the histidine precursor of diphthamide in the human elongation factor-2 gene confers resistance to diphtheria toxin.
Diphtheria
Structures of two archaeal diphthine synthases: insights into the post-translational modification of elongation factor 2.
Diphtheria
The Amidation Step of Diphthamide Biosynthesis in Yeast Requires DPH6, a Gene Identified through Mining the DPH1-DPH5 Interaction Network.
Diphtheria
The Hidden Nature of Protein Translational Control by Diphthamide - the secrets under the leather.
Diphtheria
The role of the diphthamide-containing loop within eukaryotic elongation factor 2 in ADP-ribosylation by Pseudomonas aeruginosa exotoxin A.
Diphtheria
Transition state structure for ADP-ribosylation of eukaryotic elongation factor 2 catalyzed by diphtheria toxin.
Diphtheria
Transition State Structure for the Hydrolysis of NAD Catalyzed by Diphtheria Toxin.
Diphtheria
Translation elongation factor 2 anticodon mimicry domain mutants affect fidelity and diphtheria toxin resistance.
Diphtheria
Two elongation factors from the extremely halophilic archaebacterium Halobacterium cutirubrum. Assay systems and purification at high salt concentrations.
Diphtheria
[Effect of cytochalasin D, diphtheria toxin, and ricin on the localization of eukaryotic elongation factor 2 along actin filament bundles in fibroblasts]
Diverticular Diseases
Sequence variants in ARHGAP15, COLQ and FAM155A associate with diverticular disease and diverticulitis.
Diverticulitis
Sequence variants in ARHGAP15, COLQ and FAM155A associate with diverticular disease and diverticulitis.
Down Syndrome
Proteomic profiling of amniotic fluid in preterm labor using two-dimensional liquid separation and mass spectrometry.
Drug-Related Side Effects and Adverse Reactions
ERp29 regulates response to doxorubicin by a PERK-mediated mechanism.
Dysentery, Amebic
Cloning and characterization of Entamoeba histolytica antigens recognized by human secretory IgA antibodies.
Dysplastic Nevus Syndrome
eIF4E Is an Adverse Prognostic Marker of Melanoma Patient Survival by Increasing Melanoma Cell Invasion.
Dystonia
Linking Penetrance and Transcription in DYT-THAP1: Insights From a Human iPSC-Derived Cortical Model.
Echinococcosis
Elongation factor 1 beta/delta of Echinococcus granulosus and allergic manifestations in human cystic echinococcosis.
Encephalitis
Chemoproteomic Discovery of a Ritanserin-Targeted Kinase Network Mediating Apoptotic Cell Death of Lung Tumor Cells.
Encephalitis, Japanese
MicroRNA-33a-5p Modulates Japanese Encephalitis Virus Replication by Targeting Eukaryotic Translation Elongation Factor 1A1.
Encephalitis, Japanese
Pathogenicity and virulence of Japanese encephalitis virus: Neuroinflammation and neuronal cell damage.
Encephalomyelitis
WLS/wntless is essential in controlling dendritic cell homeostasis via a WNT signaling-independent mechanism.
Encephalomyelitis, Autoimmune, Experimental
Immunohistochemical localization of phosphorylated protein kinase R and phosphorylated eukaryotic initiation factor-2 alpha in the central nervous system of SJL mice with experimental allergic encephalomyelitis.
Encephalomyelitis, Autoimmune, Experimental
WLS/wntless is essential in controlling dendritic cell homeostasis via a WNT signaling-independent mechanism.
Endometrial Neoplasms
Expression profile of eukaryotic translation initiation factor and matrix metalloproteinase 9 in endometrial cancer tissue.
Endometrial Neoplasms
Long non-coding RNA steroid receptor activator promotes the progression of endometrial cancer via Wnt/ ?-catenin signaling pathway.
Endometrial Neoplasms
MicroRNA-182 Promotes Tumor Cell Growth by Targeting Transcription Elongation Factor A-like 7 in Endometrial Carcinoma.
Endometriosis
Reduced Expression of Eukaryotic Translation Initiation Factor 3 Subunit e and Its Possible Involvement in the Epithelial-Mesenchymal Transition in Endometriosis.
Enterovirus Infections
Enterovirus-induced miR-141 contributes to shutoff of host protein translation by targeting the translation initiation factor eIF4E.
Enzootic Bovine Leukosis
Isolation and characterisation of a bovine cDNA encoding eukaryotic initiation factor 2 alpha.
Epilepsy
Cellular compartmentalization of phosphorylated eIF2alpha and neuronal NOS in human temporal lobe epilepsy with hippocampal sclerosis.
Epilepsy
Clinical efficacy of gamma knife and surgery treatment of mesial temporal lobe epilepsy and their effects on EF-Tumt and EF-Tsmt expression.
Epilepsy
Damaging de novo missense variants in EEF1A2 lead to a developmental and degenerative epileptic-dyskinetic encephalopathy.
Epilepsy
Glia activation of eukaryotic translation initiation factor 4e-binding protein 1 in temporal lobe epilepsy.
Epilepsy
Identification of MRI1, encoding translation initiation factor eIF-2B subunit alpha/beta/delta-like protein, as a candidate locus for infantile epilepsy with severe cystic degeneration of the brain.
Epilepsy
Novel de novo EEF1A2 missense mutations causing epilepsy and intellectual disability.
Epilepsy
Phosphorylation of translation initiation factor eIF2alpha in the brain during pilocarpine-induced status epilepticus in mice.
Epilepsy
Recapitulation of the EEF1A2 D252H neurodevelopmental disorder-causing missense mutation in mice reveals a toxic gain of function.
Epilepsy
Two cases of early-onset myoclonic seizures with continuous parietal delta activity caused by EEF1A2 mutations.
Epilepsy, Temporal Lobe
Cellular compartmentalization of phosphorylated eIF2alpha and neuronal NOS in human temporal lobe epilepsy with hippocampal sclerosis.
Epilepsy, Temporal Lobe
Clinical efficacy of gamma knife and surgery treatment of mesial temporal lobe epilepsy and their effects on EF-Tumt and EF-Tsmt expression.
Epilepsy, Temporal Lobe
Glia activation of eukaryotic translation initiation factor 4e-binding protein 1 in temporal lobe epilepsy.
Equine Infectious Anemia
An in vitro transcription system that recapitulates equine infectious anemia virus tat-mediated inhibition of human immunodeficiency virus type 1 Tat activity demonstrates a role for positive transcription elongation factor b and associated proteins in the mechanism of Tat activation.
Esophageal Neoplasms
Expression of the eukaryotic translation initiation factor 4E (eIF4E) and 4E-BP1 in esophageal cancer.
Esophageal Neoplasms
MDM2 is Overexpressed and Regulated by the Eukaryotic Translation Initiation Factor 4E (eIF4E) in Human Squamous Cell Carcinoma of Esophagus.
Esophageal Squamous Cell Carcinoma
Circulatory miR-98-5p levels are deregulated during diabetes and it inhibits proliferation and promotes apoptosis by targeting PPP1R15B in keratinocytes.
Esophageal Squamous Cell Carcinoma
Downregulation of IQGAP1 inhibits epithelial-mesenchymal transition via the HIF1?/VEGF-A signaling pathway in gastric cancer.
Esophageal Squamous Cell Carcinoma
EIF3H promotes aggressiveness of esophageal squamous cell carcinoma by modulating Snail stability.
Esophageal Squamous Cell Carcinoma
Eukaryotic translation initiation factor 3B accelerates the progression of esophageal squamous cell carcinoma by activating ?-catenin signaling pathway.
Familial Primary Pulmonary Hypertension
A novel BMPR2 mutation with widely disparate heritable pulmonary arterial hypertension clinical phenotype.
Fasciculation
Exposure to cypermethrin and mancozeb alters the expression profile of THBS1, SPP1, FEZ1 and GPNMB in human peripheral blood mononuclear cells.
Fatty Liver
Growth arrest and DNA damage-inducible 34 regulates liver regeneration in hepatic steatosis in mice.
Fatty Liver
Levels of Hepatic Activating Transcription Factor 6 and Caspase-3 Are Downregulated in Mice after Excessive Training.
Fatty Liver
The marine compound and elongation factor 1A1 inhibitor, didemnin B, provides benefit in western diet-induced non-alcoholic fatty liver disease.
Fibroadenoma
Differential expression of translation-associated genes in benign and malignant human breast tumours.
Fibrosarcoma
Attenuated phenotype of Costello syndrome and early death in a patient with an HRAS mutation (c.179G>T; p.Gly60Val) affecting signalling dynamics.
Fibrosarcoma
Chemoproteomic Discovery of a Ritanserin-Targeted Kinase Network Mediating Apoptotic Cell Death of Lung Tumor Cells.
Folic Acid Deficiency
Folic acid deficiency damages male reproduction via endoplasmic reticulum stress-associated PERK pathway induced by Caveolin-1 in mice.
Foot-and-Mouth Disease
Activity of the hepatitis A virus IRES requires association between the cap-binding translation initiation factor (eIF4E) and eIF4G.
Foot-and-Mouth Disease
Cleavage of eukaryotic translation initiation factor 4GII within foot-and-mouth disease virus-infected cells: identification of the L-protease cleavage site in vitro.
Foot-and-Mouth Disease
Cleavage of translation initiation factor 4AI (eIF4AI) but not eIF4AII by foot-and-mouth disease virus 3C protease: identification of the eIF4AI cleavage site.
Foot-and-Mouth Disease
Functional interaction of translation initiation factor eIF4G with the foot-and-mouth disease virus internal ribosome entry site.
Foot-and-Mouth Disease
Identification of the active-site residues of the L proteinase of foot-and-mouth disease virus.
Foot-and-Mouth Disease
Inoculation of swine with foot-and-mouth disease SAP-mutant virus induces early protection against disease.
Foot-and-Mouth Disease
Interaction of eukaryotic initiation factor eIF4B with the internal ribosome entry site of foot-and-mouth disease virus is independent of the polypyrimidine tract-binding protein.
Foot-and-Mouth Disease
Interaction of the eIF4G initiation factor with the aphthovirus IRES is essential for internal translation initiation in vivo.
Foot-and-Mouth Disease
Recognition of picornavirus internal ribosome entry sites within cells; influence of cellular and viral proteins.
Foot-and-Mouth Disease
Sequential modification of translation initiation factor eIF4GI by two different foot-and-mouth disease virus proteases within infected baby hamster kidney cells: identification of the 3Cpro cleavage site.
Foot-and-Mouth Disease
Vaccinia virus protein synthesis has a low requirement for the intact translation initiation factor eIF4F, the cap-binding complex, within infected cells.
Fragile X Syndrome
A unique binding mode of the eukaryotic translation initiation factor 4E for guiding the design of novel peptide inhibitors.
Fragile X Syndrome
Control of the eIF4E activity: structural insights and pharmacological implications.
Frontotemporal Dementia
C9orf72 ALS-FTD: recent evidence for dysregulation of the autophagy-lysosome pathway at multiple levels.
Frontotemporal Dementia
Organelle-specific autophagy in inflammatory diseases: a potential therapeutic target underlying the quality control of multiple organelles.
Frontotemporal Lobar Degeneration
ALS-FTLD-linked mutations of SQSTM1/p62 disrupt selective autophagy and NFE2L2/NRF2 anti-oxidative stress pathway.
Fuchs' Endothelial Dystrophy
Unfolded protein response in fuchs endothelial corneal dystrophy: a unifying pathogenic pathway?
Fusariosis
European Confederation of Medical Mycology (ECMM) epidemiological survey on invasive infections due to Fusarium species in Europe.
Gallbladder Neoplasms
Eukaryotic translation initiation factor 6 overexpression plays a major role in the translational control of gallbladder cancer.
Gallbladder Neoplasms
Upregulation of eukaryotic translation initiation factor 4E associates with a poor prognosis in gallbladder cancer and promotes cell proliferation in vitro and in vivo.
Gastrointestinal Neoplasms
Levels, phosphorylation status and cellular localization of translational factor eIF2 in gastrointestinal carcinomas.
Gastrointestinal Neoplasms
Overexpression of eukaryotic elongation factor eEF2 in gastrointestinal cancers and its involvement in G2/M progression in the cell cycle.
gelatinase b deficiency
Genetic removal of matrix metalloproteinase 9 rescues the symptoms of fragile X syndrome in a mouse model.
Genetic Diseases, Inborn
Peptidomics and proteomics studies of transformed lymphocytes from patients mutated for the eukaryotic initiation factor 2B.
Genetic Diseases, Inborn
Reduced growth of Drosophila neurofibromatosis 1 mutants reflects a non-cell-autonomous requirement for GTPase-Activating Protein activity in larval neurons.
Genetic Diseases, Inborn
Regulation of translation initiation factor eIF2B at the hub of the integrated stress response.
Genetic Diseases, Inborn
Role of oculocerebrorenal syndrome of Lowe (OCRL) protein in megakaryocyte maturation, platelet production and functions: a study in patients with Lowe syndrome.
Glioblastoma
Anti-vimentin, anti-TUFM, anti-NAP1L1 and anti-DPYSL2 nanobodies display cytotoxic effect and reduce glioblastoma cell migration.
Glioblastoma
Eukaryotic initiation factor 5B (eIF5B) provides a critical cell survival switch to glioblastoma cells via regulation of apoptosis.
Glioblastoma
Growth factor-independent expression of the gene encoding eukaryotic translation initiation factor 4E in transformed cell lines.
Glioblastoma
Inhibition of eukaryotic initiation factor 3B suppresses proliferation and promotes apoptosis of chronic myeloid leukemia cells.
Glioblastoma
Inhibition of glioma growth by flavokawain B is mediated through endoplasmic reticulum stress induced autophagy.
Glioblastoma
Proteomic Analysis on Anti-Proliferative and Apoptosis Effects of Curcumin Analog, 1,5-bis(4-Hydroxy-3-Methyoxyphenyl)-1,4-Pentadiene-3-One-Treated Human Glioblastoma and Neuroblastoma Cells.
Glioblastoma
Tumor suppression by PTEN requires the activation of the PKR-eIF2alpha phosphorylation pathway.
Glioma
A GTPase-activating protein for the G protein Galphaz. Identification, purification, and mechanism of action.
Glioma
ADP-ribosylation factor 6 regulates glioma cell invasion through the IQ-domain GTPase-activating protein 1-Rac1-mediated pathway.
Glioma
Decreased expression of ARHGAP15 promotes the development of colorectal cancer through PTEN/AKT/FOXO1 axis.
Glioma
Disruption of the EF-2 kinase/Hsp90 protein complex: a possible mechanism to inhibit glioblastoma by geldanamycin.
Glioma
eEF-2 Kinase Dictates Cross-Talk between Autophagy and Apoptosis Induced by Akt Inhibition, Thereby Modulating Cytotoxicity of Novel Akt Inhibitor MK-2206.
Glioma
Electrophysiology of glioma: a Rho GTPase-activating protein reduces tumor growth and spares neuron structure and function.
Glioma
Eukaryotic translation initiation factor 3, subunit C is overexpressed and promotes cell proliferation in human glioma U-87 MG cells.
Glioma
Impairment of stress granule assembly via inhibition of the eIF2alpha phosphorylation sensitizes glioma cells to chemotherapeutic agents.
Glioma
Inhibition of MNK pathways enhances cancer cell response to chemotherapy with temozolomide and targeted radionuclide therapy.
Glioma
RLIP76 is overexpressed in human glioblastomas and is required for proliferation, tumorigenesis and suppression of apoptosis.
Glioma
The PTEN/Akt pathway dictates the direct alphaVbeta3-dependent growth-inhibitory action of an active fragment of tumstatin in glioma cells in vitro and in vivo.
Glioma
Translation control by protein kinase R restricts minute virus of mice infection: role in parvovirus oncolysis.
Glioma
Xanthatin induces glioma cell apoptosis and inhibits tumor growth via activating endoplasmic reticulum stress-dependent CHOP pathway.
Glomerulonephritis, Membranous
Role of the endoplasmic reticulum unfolded protein response in glomerular epithelial cell injury.
Glycogen Storage Disease Type II
Isolation and characterisation of a recombinant, precursor form of lysosomal acid alpha-glucosidase.
Head and Neck Neoplasms
eIF4E-targeted suicide gene therapy in a minimal residual mouse model for metastatic soft-tissue head and neck squamous cell carcinoma improves disease-free survival.
Head and Neck Neoplasms
Expression of the translation initiation factor eIF4E in the polyp-cancer sequence in the colon.
Head and Neck Neoplasms
Understanding and Targeting the Eukaryotic Translation Initiation Factor eIF4E in Head and Neck Cancer.
Hearing Loss
An Alteration in ELMOD3, an Arl2 GTPase-Activating Protein, Is Associated with Hearing Impairment in Humans.
Hearing Loss
Elmod3 knockout leads to progressive hearing loss and abnormalities in cochlear hair cell stereocilia.
Heart Failure
Reduced endoplasmic reticulum stress might alter the course of heart failure via caspase-12 and JNK pathways.
Heart Failure
[Salubrinal improves cardiac function in rats with heart failure post myocardial infarction through reducing endoplasmic reticulum stress-associated apoptosis].
Hemangiosarcoma
Alterations of the p53 and PIK3CA/AKT/mTOR pathways in angiosarcomas: A pattern distinct from other sarcomas with complex genomics.
Hematologic Neoplasms
Eukaryotic translation initiation factor 4E as a novel therapeutic target in hematological malignancies and beyond.
Hemolytic-Uremic Syndrome
Demonstration of RNA N-glycosidase activity of a Vero toxin (VT2 variant) produced by Escherichia coli O91:H21 from a patient with the hemolytic uremic syndrome.
Hemophilia A
Omental implantation of BOECs in hemophilia dogs results in circulating FVIII antigen and a complex immune response.
Hemophilia A
Restoration of FVIII expression by targeted gene insertion in the FVIII locus in hemophilia A patient-derived iPSCs.
Hepatitis
Baculoviral vector-mediated transient and stable transgene expression in human embryonic stem cells.
Hepatitis
Combinatorial control of human RNA polymerase II (RNAP II) pausing and transcript cleavage by transcription factor IIF, hepatitis delta antigen, and stimulatory factor II.
Hepatitis
Eukaryotic elongation factor 2 controls TNF-? translation in LPS-induced hepatitis.
Hepatitis
Foreign gene expression and induction of antibody response by recombinant fowl adenovirus-9-based vectors with exogenous promoters.
Hepatitis
Highly efficient lentiviral gene transfer in CD34+ and CD34+/38-/lin- cells from mobilized peripheral blood after cytokine prestimulation.
Hepatitis
The combined use of viral transcriptional and post-transcriptional regulatory elements to improve baculovirus-mediated transient gene expression in human embryonic stem cells.
Hepatitis A
Activity of the hepatitis A virus IRES requires association between the cap-binding translation initiation factor (eIF4E) and eIF4G.
Hepatitis B
Association of Elongation Factor Tu GTP-binding Domain-containing 2 Gene (EFTUD2) Polymorphism with the Risk of Hepatitis B Virus Infection.
Hepatitis B
CCDC88A/GIV promotes HBV replication and progeny secretion via enhancing endosomal trafficking and blocking autophagic degradation.
Hepatitis B
Identification of new autoantigens for primary biliary cirrhosis using human proteome microarrays.
Hepatitis B
Incorporation of eukaryotic translation initiation factor eIF4E into viral nucleocapsids via interaction with hepatitis B viral polymerase.
Hepatitis B
Increased expression of stathmin and elongation factor 1? in precancerous nodules with telomere dysfunction in hepatitis B viral cirrhotic patients.
Hepatitis B
The translation initiation factor, hu-Sui1 may be a target of hepatitis B X antigen in hepatocarcinogenesis.
Hepatitis C
A single immunization with a plasmid encoding hepatitis C virus (HCV) structural proteins under the elongation factor 1-alpha promoter elicits HCV-specific cytotoxic T-lymphocytes (CTL).
Hepatitis C
Amino acid substitutions in PKR-eIF2 phosphorylation homology domain (PePHD) of hepatitis C virus E2 protein in genotype 2a/2b and 1b in Japan and interferon efficacy.
Hepatitis C
Cap-dependent and hepatitis C virus internal ribosome entry site-mediated translation are modulated by phosphorylation of eIF2alpha under oxidative stress.
Hepatitis C
Cross-correlation of common lines: a novel approach for single-particle reconstruction of a structure containing a flexible domain.
Hepatitis C
dsRNA-dependent protein kinase PKR and its role in stress, signaling and HCV infection.
Hepatitis C
Establishment and Application of a High Throughput Screening System Targeting the Interaction between HCV Internal Ribosome Entry Site and Human Eukaryotic Translation Initiation Factor 3.
Hepatitis C
Eukaryotic translation initiation factor 4AII contributes to microRNA-122 regulation of hepatitis C virus replication.
Hepatitis C
Eukaryotic translation initiation machinery can operate in a bacterial-like mode without eIF2.
Hepatitis C
Hepatic interferon-stimulated genes are differentially regulated in the liver of chronic hepatitis C patients with different interleukin-28B genotypes.
Hepatitis C
Hepatitis C virus NS4A inhibits cap-dependent and the viral IRES-mediated translation through interacting with eukaryotic elongation factor 1A.
Hepatitis C
Identification of new autoantigens for primary biliary cirrhosis using human proteome microarrays.
Hepatitis C
Iron regulates hepatitis C virus translation via stimulation of expression of translation initiation factor 3.
Hepatitis C
La protein is a potent regulator of replication of hepatitis C virus in patients with chronic hepatitis C through internal ribosomal entry site-directed translation.
Hepatitis C
Protein kinase R is increased and is functional in hepatitis C virus-related hepatocellular carcinoma.
Hepatitis C
Protein synthesis and endoplasmic reticulum stress can be modulated by the hepatitis C virus envelope protein E2 through the eukaryotic initiation factor 2alpha kinase PERK.
Hepatitis C
Specific interaction of eukaryotic translation initiation factor 3 with the 5' nontranslated regions of hepatitis C virus and classical swine fever virus RNAs.
Hepatitis C
Structure of the mammalian 80S initiation complex with initiation factor 5B on HCV-IRES RNA.
Hepatitis C
TBC1D20 is a Rab1 GTPase-activating protein that mediates hepatitis C virus replication.
Hepatitis C
The Initiation Factors eIF2, eIF2A, eIF2D, eIF4A, and eIF4G Are Not Involved in Translation Driven by Hepatitis C Virus IRES in Human Cells.
Hepatitis C
The interaction between human initiation factor eIF3 subunit c and heat-shock protein 90: a necessary factor for translation mediated by the hepatitis C virus internal ribosome entry site.
Hepatitis C
Unlike for cellular mRNAs and other viral internal ribosome entry sites (IRESs), the eIF3 subunit e is not required for the translational activity of the HCV IRES.
Hepatitis E
Requirement of the eukaryotic translation initiation factor 4F complex in hepatitis E virus replication.
Hepatitis, Autoimmune
Identification of new autoantigens for primary biliary cirrhosis using human proteome microarrays.
Hepatitis, Chronic
Identification of hepatocellular-carcinoma-associated antigens and autoantibodies by serological proteome analysis combined with protein microarray.
Herpes Simplex
A conserved domain of herpes simplex virus ICP34.5 regulates protein phosphatase complex in mammalian cells.
Herpes Simplex
A herpesvirus ribosome-associated, RNA-binding protein confers a growth advantage upon mutants deficient in a GADD34-related function.
Herpes Simplex
A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress.
Herpes Simplex
Adeno-associated viruses can induce phosphorylation of eIF2alpha via PKR activation, which can be overcome by helper adenovirus type 5 virus-associated RNA.
Herpes Simplex
Association of a M(r) 90,000 phosphoprotein with protein kinase PKR in cells exhibiting enhanced phosphorylation of translation initiation factor eIF-2 alpha and premature shutoff of protein synthesis after infection with gamma 134.5- mutants of herpes simplex virus 1.
Herpes Simplex
Cellular elongation factor 1delta is modified in cells infected with representative alpha-, beta-, or gammaherpesviruses.
Herpes Simplex
Conserved protein kinases encoded by herpesviruses and cellular protein kinase cdc2 target the same phosphorylation site in eukaryotic elongation factor 1delta.
Herpes Simplex
CRISPR/Cas9-Mediated Knockin Application in Cell Therapy: A Non-viral Procedure for Bystander Treatment of Glioma in Mice.
Herpes Simplex
Dephosphorylation of eIF2{alpha} Mediated by the {gamma}134.5 Protein of Herpes Simplex Virus 1 Facilitates Viral Neuroinvasion.
Herpes Simplex
Epstein-Barr virus-encoded protein kinase BGLF4 mediates hyperphosphorylation of cellular elongation factor 1delta (EF-1delta): EF-1delta is universally modified by conserved protein kinases of herpesviruses in mammalian cells.
Herpes Simplex
Eukaryotic elongation factor 1delta is hyperphosphorylated by the protein kinase encoded by the U(L)13 gene of herpes simplex virus 1.
Herpes Simplex
In vitro and in vivo characterization of a dual-function green fluorescent protein--HSV1-thymidine kinase reporter gene driven by the human elongation factor 1 alpha promoter.
Herpes Simplex
Increased eIF2alpha phosphorylation attenuates replication of herpes simplex virus 2 vhs mutants in mouse embryonic fibroblasts and correlates with reduced accumulation of the PKR antagonist ICP34.5.
Herpes Simplex
Interaction of herpes simplex virus 1 alpha regulatory protein ICP0 with elongation factor 1delta: ICP0 affects translational machinery.
Herpes Simplex
Neutralizing innate host defenses to control viral translation in HSV-1 infected cells.
Herpes Simplex
Regulation of eIF2alpha phosphorylation by different functions that act during discrete phases in the herpes simplex virus type 1 life cycle.
Herpes Simplex
Regulation of starvation- and virus-induced autophagy by the eIF2alpha kinase signaling pathway.
Herpes Simplex
Second-site mutation outside of the U(S)10-12 domain of Deltagamma(1)34.5 herpes simplex virus 1 recombinant blocks the shutoff of protein synthesis induced by activated protein kinase R and partially restores neurovirulence.
Herpes Simplex
The gamma(1)34.5 protein of herpes simplex virus 1 complexes with protein phosphatase 1alpha to dephosphorylate the alpha subunit of the eukaryotic translation initiation factor 2 and preclude the shutoff of protein synthesis by double-stranded RNA-activated protein kinase.
Herpes Simplex
The herpes simplex virus US11 protein effectively compensates for the gamma1(34.5) gene if present before activation of protein kinase R by precluding its phosphorylation and that of the alpha subunit of eukaryotic translation initiation factor 2.
Huntington Disease
A chemical genomics-aggrephagy integrated method studying functional analysis of autophagy inducers.
Huntington Disease
Connecting the dots in Huntington's disease with protein interaction networks.
Hydatidiform Mole
Evolution of human-specific neural SRGAP2 genes by incomplete segmental duplication.
Hydatidiform Mole
Expression of Ras GTPase-activating protein (GAP) in human normal chorionic villi and hydatidiform mole.
Hydrocephalus
Disruption of wave-associated Rac GTPase-activating protein (Wrp) leads to abnormal adult neural progenitor migration associated with hydrocephalus.
Hyperalgesia
The RhoA GTPase-Activating Protein DLC2 Modulates RhoA Activity and Hyperalgesia to Noxious Thermal and Inflammatory Stimuli.
Hypersensitivity
Allergenic and antigenic determinants of latex allergen Hev b 1: peptide mapping of epitopes recognized by human, murine and rabbit antibodies.
Hypersensitivity
Translational control by eIF2? phosphorylation regulates vulnerability to the synaptic and behavioral effects of cocaine.
Hypersensitivity
Translational control of nicotine-evoked synaptic potentiation in mice and neuronal responses in human smokers by eIF2?.
Hypertension
A novel BMPR2 mutation with widely disparate heritable pulmonary arterial hypertension clinical phenotype.
Hypertension
Clinical characteristics and survival of Chinese patients diagnosed with pulmonary arterial hypertension who carry BMPR2 or EIF2KAK4 variants.
Hypertension
Glucagon-like peptide-1 attenuates cardiac hypertrophy via the AngII/AT1R/ACE2 and AMPK/mTOR/p70S6K pathways.
Hypertension
Regulation of phospholipase C-delta1 by ARGHAP6, a GTPase-activating protein for RhoA: possible role for enhanced activity of phospholipase C in hypertension.
Hypertension
The impact of insulin-like growth factor-1 on the pattern of cardiac elongation factor-2 variants in a model of overload.
Hypertension, Pulmonary
Pulmonary pressure reduction attenuates expression of proteins identified by lung proteomic profiling in pulmonary hypertensive rats.
Hypertension, Pulmonary
Unique wreath-like smooth muscle proliferation of the pulmonary vasculature in pulmonary veno-occlusive disease versus pulmonary arterial hypertension.
Hypoglycemia
Initiation of protein synthesis and heat-shock protein-72 expression in the rat brain following severe insulin-induced hypoglycemia.
Hypoglycemia
Translational control is required for the unfolded protein response and in vivo glucose homeostasis.
Hypothyroidism
Hypothyroidism decreases proinsulin gene expression and the attachment of its mRNA and eEF1A protein to the actin cytoskeleton of INS-1E cells.
Ileitis
Villin-1 and Gelsolin Regulate Changes in Actin Dynamics That Affect Cell Survival Signaling Pathways and Intestinal Inflammation.
Infarction, Middle Cerebral Artery
Dynamic mislocalizations of nuclear pore complex proteins after focal cerebral ischemia in rat.
Infections
A host RNA helicase-like protein, AtRH8, interacts with the potyviral genome-linked protein, VPg, associates with the virus accumulation complex, and is essential for infection.
Infections
A kinase able to phosphorylate exogenous protein synthesis initiation factor eIF-2 alpha is present in lysates of mengovirus-infected L cells.
Infections
A negative elongation factor E inhibits white spot syndrome virus replication by suppressing promoter activity of the viral immediate early genes in red claw crayfish Cherax quadricarinatus.
Infections
Activating Ras Mutations Fail to Ensure Efficient Replication of Adenovirus Mutants Lacking VA-RNA.
Infections
Activation of double-stranded RNA-activated protein kinase in HeLa cells after poliovirus infection does not result in increased phosphorylation of eucaryotic initiation factor-2.
Infections
Activation of NF-kappaB in cells productively infected with HSV-1 depends on activated protein kinase R and plays no apparent role in blocking apoptosis.
Infections
Adenovirus VAI RNA prevents phosphorylation of the eukaryotic initiation factor 2 alpha subunit subsequent to infection.
Infections
Allele mining in the pepper gene pool provided new complementation effects between pvr2-eIF4E and pvr6-eIF(iso)4E alleles for resistance to pepper veinal mottle virus.
Infections
An evaluation of potential reference genes for stability of expression in two salmonid cell lines after infection with either Piscirickettsia salmonis or IPNV.
Infections
Antiviral effects of geranylgeranylacetone: enhancement of MxA expression and phosphorylation of PKR during influenza virus infection.
Infections
Association of a M(r) 90,000 phosphoprotein with protein kinase PKR in cells exhibiting enhanced phosphorylation of translation initiation factor eIF-2 alpha and premature shutoff of protein synthesis after infection with gamma 134.5- mutants of herpes simplex virus 1.
Infections
Binding and nuclear relocalization of protein kinase R by human cytomegalovirus TRS1.
Infections
Binding between elongation factor 1A and the 3'-UTR of Chinese wheat mosaic virus is crucial for virus infection.
Infections
Biomphalaria glabrata transcriptome: cDNA microarray profiling identifies resistant- and susceptible-specific gene expression in haemocytes from snail strains exposed to Schistosoma mansoni.
Infections
Bisifusarium Delphinoides, an Emerging Opportunistic Pathogen in a Burn Patient with Diabetes Mellitus.
Infections
Caspases are not involved in the cleavage of translation initiation factor eIF4GI during picornavirus infection.
Infections
Cellular elongation factor 1delta is modified in cells infected with representative alpha-, beta-, or gammaherpesviruses.
Infections
Characterization of rainbow trout and zebrafish eukaryotic initiation factor 2alpha and its response to endoplasmic reticulum stress and IPNV infection.
Infections
Chlamydophila (Chlamydia) pneumoniae infection promotes vascular smooth muscle cell adhesion and migration through IQ domain GTPase-activating protein 1.
Infections
Cleavage of DAP5 by coxsackievirus B3 2A protease facilitates viral replication and enhances apoptosis by altering translation of IRES-containing genes.
Infections
Cleavage of poly(A)-binding protein by enterovirus proteases concurrent with inhibition of translation in vitro.
Infections
Conidial Morphogenesis and Septin-Mediated Plant Infection Require Smo1, a Ras GTPase-Activating Protein in Magnaporthe oryzae.
Infections
Contribution of MX dynamin, oligoadenylate synthetase, and protein kinase R to anti-paramyxovirus activity of type 1 interferons in vitro.
Infections
Coronavirus infection modulates the unfolded protein response and mediates sustained translational repression.
Infections
Coxsackievirus B3 modulates cell death by downregulating activating transcription factor 3 in HeLa cells.
Infections
Coxsackievirus B3 replication is reduced by inhibition of the extracellular signal-regulated kinase (ERK) signaling pathway.
Infections
Cryptosporidium parvum elongation factor 1? (CpEF1?) participates in the formation of base structure at the infection site during invasion.
Infections
Deficiency of the eIF4E isoform nCBP limits the cell-to-cell movement of a plant virus encoding triple-gene-block proteins in Arabidopsis thaliana.
Infections
Differential regulation of type I interferon and epidermal growth factor pathways by a human Respirovirus virulence factor.
Infections
Downregulation of protein kinase PKR activation by porcine reproductive and respiratory syndrome virus at its early stage infection.
Infections
dsRNA-dependent protein kinase PKR and its role in stress, signaling and HCV infection.
Infections
Dual mechanism for the translation of subgenomic mRNA from Sindbis virus in infected and uninfected cells.
Infections
Effect of T4 infection on initiation of protein synthesis and messenger specificity of initiation factor 3.
Infections
Effects of variant rs346473 in ARHGAP24 gene on disease progression of HBV infection in han Chinese population.
Infections
Efficient cleavage of ribosome-associated poly(A)-binding protein by enterovirus 3C protease.
Infections
Ehrlichia secretes Etf-1 to induce autophagy and capture nutrients for its growth through RAB5 and class III phosphatidylinositol 3-kinase.
Infections
Elongation factor 1 (EF1alpha) promoter in a lentiviral backbone improves expression of the CD20 suicide gene in primary T lymphocytes allowing efficient rituximab-mediated lysis.
Infections
Eukaryotic elongation factor 1 complex subunits are critical HIV-1 reverse transcription cofactors.
Infections
Eukaryotic elongation factor 1A interacts with Turnip mosaic virus RNA-dependent RNA polymerase and VPg-Pro in virus-induced vesicles.
Infections
Evolution of plant eukaryotic initiation factor 4E (eIF4E) and potyvirus genome-linked protein (VPg): A game of mirrors impacting resistance spectrum and durability.
Infections
First Comprehensive Report of Clinical Fusarium Strains Isolated in the State of Sao Paulo (Brazil) and Identified by MALDI-TOF MS and Molecular Biology.
Infections
Flavivirus Infection Uncouples Translation Suppression from Cellular Stress Responses.
Infections
Foot-and-mouth disease virus infection induces proteolytic cleavage of PTB, eIF3a,b, and PABP RNA-binding proteins.
Infections
Functional domains and the antiviral effect of the double-stranded RNA-dependent protein kinase PKR from Paralichthys olivaceus.
Infections
Functional genomic analysis of herpes simplex virus type 1 counteraction of the host innate response.
Infections
Genotype 2 strains of porcine reproductive and respiratory syndrome virus dysregulate alveolar macrophage cytokine production via the unfolded protein response.
Infections
Global protein profiling studies of chikungunya virus infection identify different proteins but common biological processes.
Infections
Helicobacter pylori in a Korean Isolate Expressed Proteins Differentially in Human Gastric Epithelial Cells.
Infections
Helper component proteinase of the genus Potyvirus is an interaction partner of translation initiation factors eIF(iso)4E and eIF4E and contains a 4E binding motif.
Infections
Hepatitis C virus blocks interferon effector function by inducing protein kinase R phosphorylation.
Infections
Hepatitis C virus hijacks P-body and stress granule components around lipid droplets.
Infections
Herpes simplex virus 1 infection activates the endoplasmic reticulum resident kinase PERK and mediates eIF-2alpha dephosphorylation by the gamma(1)34.5 protein.
Infections
High-level sustained transgene expression in human embryonic stem cells using lentiviral vectors.
Infections
Highly pathogenic New World arenavirus infection activates the pattern recognition receptor PKR without attenuating virus replication in human cells.
Infections
Host and viral translational mechanisms during cricket paralysis virus infection.
Infections
Human cytomegalovirus infection activates and regulates the unfolded protein response.
Infections
Human cytomegalovirus protein pUL38 induces ATF4 expression, inhibits persistent JNK phosphorylation, and suppresses endoplasmic reticulum stress-induced cell death.
Infections
Human cytomegalovirus pUL79 is an elongation factor of RNA polymerase II for viral gene transcription.
Infections
Human herpesvirus 6A (HHV-6A) exhibits restrictive propagation with limited activation of PKR-eIF2? stress pathway.
Infections
Human Management of a Wild Plant Modulates the Evolutionary Dynamics of a Gene Determining Recessive Resistance to Virus Infection.
Infections
Immunization and Drug Metabolizing Enzymes: Focus on Hepatic Cytochrome P450 3A.
Infections
Immunization with pneumococcal elongation factor Tu enhances serotype-independent protection against Streptococcus pneumoniae infection.
Infections
Importance of eIF2alpha phosphorylation and stress granule assembly in alphavirus translation regulation.
Infections
Increased eIF2alpha phosphorylation attenuates replication of herpes simplex virus 2 vhs mutants in mouse embryonic fibroblasts and correlates with reduced accumulation of the PKR antagonist ICP34.5.
Infections
Infection of human B lymphoma cells by Mycoplasma fermentans induces interaction of its elongation factor with the intracytoplasmic domain of Epstein-Barr virus receptor (gp140, EBV/C3dR, CR2, CD21).
Infections
Inhibition of HeLa cell protein synthesis following poliovirus infection correlates with the proteolysis of a 220,000-dalton polypeptide associated with eucaryotic initiation factor 3 and a cap binding protein complex.
Infections
Inhibition of host and viral translation during vesicular stomatitis virus infection. eIF2 is responsible for the inhibition of viral but not host translation.
Infections
Inhibition of protein synthesis in reovirus-infected HeLa cells with elevated levels of interferon-induced protein kinase activity.
Infections
Lentiviral Transfection of Ependymal Primary Cultures Facilitates the Characterisation of Kinocilia-specific Promoters.
Infections
Limitations of dual-fluorescent HIV reporter viruses in a model of pre-activation latency.
Infections
M. tuberculosis PknG manipulates host autophagy flux to promote pathogen intracellular survival.
Infections
Mammalian Orthoreovirus Factories Modulate Stress Granule Protein Localization by Interaction with G3BP1.
Infections
Mammalian orthoreovirus particles induce and are recruited into stress granules at early times postinfection.
Infections
Multiple eIF4GI-specific protease activities present in uninfected and poliovirus-infected cells.
Infections
Mycoplasma genitalium rapidly disseminates to the upper reproductive tracts and knees of female mice following vaginal inoculation.
Infections
Mycoplasma hyopneumoniae Inhibits Porcine Beta-Defensin 2 Production by Blocking the Unfolded Protein Response To Facilitate Epithelial Adhesion and Infection.
Infections
Novel dengue virus inhibitor 4-HPR activates ATF4 independent of protein kinase R-like Endoplasmic Reticulum Kinase and elevates levels of eIF2? phosphorylation in virus infected cells.
Infections
Nuclear factor kappa B is required for the production of infectious human herpesvirus 8 virions.
Infections
p38 and OGT sequestration into viral inclusion bodies in cells infected with human respiratory syncytial virus suppresses MK2 activities and stress granule assembly.
Infections
Phosphorylation of elongation factor G and ribosomal protein S6 in bacteriophage T7-infected Escherichia coli.
Infections
PKR activation enhances replication of classical swine fever virus in PK-15 cells.
Infections
PKR is not required for interferon-gamma inhibition of VSV replication in neurons.
Infections
PKR protein kinase is activated by hepatitis C virus and inhibits viral replication through translational control.
Infections
Plant Translation Elongation Factor 1B? Facilitates Potato Virus X (PVX) Infection and Interacts with PVX Triple Gene Block Protein 1.
Infections
Poliovirus Switches to an eIF2-Independent Mode of Translation during Infection.
Infections
Protective effects of sodium butyrate on rotavirus inducing endoplasmic reticulum stress-mediated apoptosis via PERK-eIF2? signaling pathway in IPEC-J2 cells.
Infections
Proteolysis of human eukaryotic translation initiation factor eIF4GII, but not eIF4GI, coincides with the shutoff of host protein synthesis after poliovirus infection.
Infections
Proteome analysis reveals translational inhibition of Caenorhabditis elegans enhances susceptibility to Pseudomonas aeruginosa PAO1 pathogenesis.
Infections
Proteomics analysis of host cells infected with infectious bursal disease virus.
Infections
Proteomics unravels new candidate genes for Meloidogyne resistance in wild Arachis.
Infections
Purification and Analysis of Effector Glucosyltransferase Lgt1 from Legionella pneumophila.
Infections
Regulation of eIF2alpha phosphorylation by different functions that act during discrete phases in the herpes simplex virus type 1 life cycle.
Infections
Regulation of mRNA translation and cellular signaling by hepatitis C virus nonstructural protein NS5A.
Infections
Relative contributions of Pseudomonas aeruginosa ExoU, ExoS, and ExoT to virulence in the lung.
Infections
Replication and cytopathic effect of oncolytic vesicular stomatitis virus in hypoxic tumor cells in vitro and in vivo.
Infections
Replication of a cytopathic strain of bovine viral diarrhea virus activates PERK and induces endoplasmic reticulum stress-mediated apoptosis of MDBK cells.
Infections
Respiratory syncytial virus limits alpha subunit of eukaryotic translation initiation factor 2 (eIF2alpha) phosphorylation to maintain translation and viral replication.
Infections
Rift Valley fever virus NSs protein promotes post-transcriptional downregulation of protein kinase PKR and inhibits eIF2alpha phosphorylation.
Infections
Selective Editing of Herpes Simplex Virus 1 Enables Interferon Induction and Viral Replication That Destroy Malignant Cells.
Infections
Selective Interaction of Sugarcane eIF4E with VPgs from Sugarcane Mosaic Pathogens.
Infections
Sendai virus C protein plays a role in restricting PKR activation by limiting the generation of intracellular double-stranded RNA.
Infections
Sequential modification of translation initiation factor eIF4GI by two different foot-and-mouth disease virus proteases within infected baby hamster kidney cells: identification of the 3Cpro cleavage site.
Infections
Severe acute respiratory syndrome coronavirus triggers apoptosis via protein kinase R but is resistant to its antiviral activity.
Infections
Shared and Distinct Aspects of the Sepsis Transcriptomic Response to Fecal Peritonitis and Pneumonia.
Infections
Significance of eukaryotic translation elongation factor 1A in tobacco mosaic virus infection.
Infections
Single-cell transcriptomic analysis reveals key immune cell phenotypes in the lungs of patients with asthma exacerbation.
Infections
Species-specific inhibition of capripoxvirus replication by host antiviral protein kinase R.
Infections
Specific inhibition of the PKR-mediated antiviral response by the murine cytomegalovirus proteins m142 and m143.
Infections
Specific peptide-activated proteolytic cleavage of Escherichia coli elongation factor Tu.
Infections
Stress-induced apoptosis in Spodoptera frugiperda (Sf9) cells: baculovirus p35 mitigates eIF2 alpha phosphorylation.
Infections
Successive synovial Mycoplasma hominis isolates exhibit apparent antigenic variation.
Infections
The Absence of Eukaryotic Initiation Factor eIF(iso)4E Affects the Systemic Spread of a Tobacco etch virus Isolate in Arabidopsis thaliana.
Infections
The adenovirus E1B 55-kilodalton and E4 open reading frame 6 proteins limit phosphorylation of eIF2alpha during the late phase of infection.
Infections
The alpha subunit of eucaryotic initiation factor 2 is phosphorylated in mengovirus-infected mouse L cells.
Infections
The elongation factor Tu coded by the tufA gene of Escherichia coli K-12 is almost identical to that coded by the tufB gene.
Infections
The experimental analysis of mimivirus translation initiation factor 4a reveals its importance for viral proteins translation during infection of
Infections
The major head protein of bacteriophage T4 binds specifically to elongation factor Tu.
Infections
The mammalian host protein DAP5 facilitates the initial round of translation of Coxsackievirus B3 RNA.
Infections
The MyD116 African swine fever virus homologue interacts with the catalytic subunit of protein phosphatase 1 and activates its phosphatase activity.
Infections
The Potyviral P3 Protein Targets Eukaryotic Elongation Factor 1A to Promote the Unfolded Protein Response and Viral Pathogenesis.
Infections
The potyvirus recessive resistance gene, sbm1, identifies a novel role for translation initiation factor eIF4E in cell-to-cell trafficking.
Infections
The secreted protein kinase CstK from Coxiella burnetii influences vacuole development and interacts with the GTPase-activating host protein TBC1D5.
Infections
The ubiquitin-proteasome system plays an important role during various stages of the coronavirus infection cycle.
Infections
Tick-borne encephalitis virus delays interferon induction and hides its double-stranded RNA in intracellular membrane vesicles.
Infections
Transcriptomic study of 39 ostreid herpesvirus 1 genes during an experimental infection.
Infections
Translation control by protein kinase R restricts minute virus of mice infection: role in parvovirus oncolysis.
Infections
Translation elongation factor 1B (eEF1B) is an essential host factor for Tobacco mosaic virus infection in plants.
Infections
Translation of both 5'TOP and non-TOP host mRNAs continues into the late phase of Baculovirus infection.
Infections
Translation of eukaryotic translation initiation factor 4GI (eIF4GI) proceeds from multiple mRNAs containing a novel cap-dependent internal ribosome entry site (IRES) that is active during poliovirus infection.
Infections
Translational resistance of late alphavirus mRNA to eIF2alpha phosphorylation: a strategy to overcome the antiviral effect of protein kinase PKR.
Infections
Vibrio cholerae T3SS effector VopE modulates mitochondrial dynamics and innate immune signaling by targeting Miro GTPases.
Infections
Viral host range factors C7 or K1 are essential for modified vaccinia virus Ankara late gene expression in human and murine cells, irrespective of their capacity to inhibit PKR-mediated eIF2{alpha} phosphorylation.
Infections
Zika Virus Induces an Atypical Tripartite Unfolded Protein Response with Sustained Sensor and Transient Effector Activation and a Blunted BiP Response.
Infertility
TBC1D21 Potentially Interacts with and Regulates Rap1 during Murine Spermatogenesis.
Infertility, Male
Mutation of Eif4g3, encoding a eukaryotic translation initiation factor, causes male infertility and meiotic arrest of mouse spermatocytes.
Inflammatory Bowel Diseases
New insights into the interplay between autophagy, gut microbiota and inflammatory responses in IBD.
Inflammatory Breast Neoplasms
Inflammatory breast cancer cells are constitutively adapted to hypoxia.
Influenza, Human
Binding of the influenza virus NS1 protein to double-stranded RNA inhibits the activation of the protein kinase that phosphorylates the elF-2 translation initiation factor.
Influenza, Human
Eukaryotic Translation Elongation Factor 1 Delta Inhibits the Nuclear Import of the Nucleoprotein and PA-PB1 Heterodimer of Influenza A Virus.
Influenza, Human
Eukaryotic translation initiation factor 4GI is a cellular target for NS1 protein, a translational activator of influenza virus.
Influenza, Human
Influenza A virus protein PB1-F2 impairs innate immunity by inducing mitophagy.
Influenza, Human
Influenza A virus-induced degradation of eukaryotic translation initiation factor 4B contributes to viral replication by suppressing IFITM3 protein expression.
Influenza, Human
Influenza Virus mRNA Translation Revisited: Is the eIF4E Cap-Binding Factor Required for Viral mRNA Translation?
Influenza, Human
Inhibition of Avian Influenza A Virus Replication in Human Cells by Host Restriction Factor TUFM Is Correlated with Autophagy.
Influenza, Human
Modification of eukaryotic initiation factor 4F during infection by influenza virus.
Influenza, Human
PABP1 and eIF4GI associate with influenza virus NS1 protein in viral mRNA translation initiation complexes.
Influenza, Human
Peptide-Mediated Interference of PB2-eIF4G1 Interaction Inhibits Influenza A Viruses' Replication in Vitro and in Vivo.
Influenza, Human
Strain-Specific Contribution of Eukaryotic Elongation Factor 1 Gamma to the Translation of Influenza A Virus Proteins.
Influenza, Human
Stress Granule-Inducing Eukaryotic Translation Initiation Factor 4A Inhibitors Block Influenza A Virus Replication.
Influenza, Human
The cellular protein P58IPK regulates influenza virus mRNA translation and replication through a PKR-mediated mechanism.
Influenza, Human
The role and assembly mechanism of nucleoprotein in influenza A virus ribonucleoprotein complexes.
Influenza, Human
VSV replication in neurons is inhibited by type I IFN at multiple stages of infection.
Insulin Resistance
Impaired overload-induced hypertrophy is associated with diminished mTOR signaling in insulin resistant skeletal muscle of the obese Zucker rat.
Insulin Resistance
Jiangtang Xiaoke granule attenuates glucose metabolism disorder via regulating endoplasmic reticulum stress in the liver of type 2 diabetes mellitus mice.
Insulin Resistance
The ABCG5 ABCG8 Sterol Transporter Opposes the Development of Fatty Liver Disease and Loss of Glycemic Control Independently of Phytosterol Accumulation.
Intellectual Disability
Analysis on the emerging role of Rab3 GTPase-activating protein in Warburg Micro and Martsolf syndrome.
Intellectual Disability
Convergence of Hippocampal Pathophysiology in Syngap+/- and Fmr1-/y Mice.
Intellectual Disability
Damaging de novo missense variants in EEF1A2 lead to a developmental and degenerative epileptic-dyskinetic encephalopathy.
Intellectual Disability
De novo, heterozygous, loss-of-function mutations in SYNGAP1 cause a syndromic form of intellectual disability.
Intellectual Disability
Expression of MicroRNA machinery proteins in different types of chronic rhinosinusitis.
Intellectual Disability
Homozygous mutation in the eukaryotic translation initiation factor 2alpha phosphatase gene, PPP1R15B, is associated with severe microcephaly, short stature and intellectual disability.
Intellectual Disability
Mild epileptic phenotype associates with de novo eef1a2 mutation: Case report and review.
Intellectual Disability
Oligophrenin-1 regulates number, morphology and synaptic properties of adult-born inhibitory interneurons in the olfactory bulb.
Intellectual Disability
Recapitulation of the EEF1A2 D252H neurodevelopmental disorder-causing missense mutation in mice reveals a toxic gain of function.
Intellectual Disability
Successful treatment of choreo-athetotic movements in a patient with an EEF1A2 gene variant.
Intellectual Disability
Suppression of MEHMO Syndrome Mutation in eIF2 by Small Molecule ISRIB.
Intellectual Disability
The fragile X mental retardation protein FMRP binds elongation factor 1A mRNA and negatively regulates its translation in vivo.
Intellectual Disability
Two cases of early-onset myoclonic seizures with continuous parietal delta activity caused by EEF1A2 mutations.
Intestinal Volvulus
Translational elongation factor 1 alpha (EF-1 alpha) of Onchocerca volvulus.
Ischemic Attack, Transient
Stress-induced inhibition of protein synthesis initiation: modulation of initiation factor 2 and guanine nucleotide exchange factor activities following transient cerebral ischemia in the rat.
Ischemic Contracture
A small molecule AMPK activator protects the heart against ischemia-reperfusion injury.
Ischemic Stroke
Growth arrest and DNA damage-inducible protein 34 (GADD34) contributes to cerebral ischemic injury and can be detected in plasma exosomes.
Ischemic Stroke
Neuroprotection Mediated by Upregulation of Endothelial Nitric Oxide Synthase in Rho-Associated, Coiled-Coil-Containing Kinase 2 Deficient Mice.
Keratitis
[Molecular identification and in vitro susceptibility of Fusarium from fungal keratitis in central China].
Ketosis
Identification of IQ motif-containing GTPase-activating protein 1 as a regulator of long-term ketosis.
Kidney Calculi
Elongation factor Tu on Escherichia coli isolated from urine of kidney stone patients promotes calcium oxalate crystal growth and aggregation.
Kidney Neoplasms
A miRNA- and mRNA-seq-Based Feature Selection Approach for Kidney Cancer Biomakers.
Langer-Giedion Syndrome
The EIF3S3 gene encoding the p40 subunit of the translation initiation factor eIF3 has eight exons and maps to the Langer-Giedion syndrome chromosome region on 8q24, but is not the TRPS1 gene.
Latent Infection
Limitations of dual-fluorescent HIV reporter viruses in a model of pre-activation latency.
Latex Hypersensitivity
IgE antibodies to prohevein, hevein, and rubber elongation factor in children with latex allergy.
Latex Hypersensitivity
The 14.6 kd rubber elongation factor (Hev b 1) and 24 kd (Hev b 3) rubber particle proteins are recognized by IgE from patients with spina bifida and latex allergy.
Latex Hypersensitivity
Unique and shared IgE epitopes of Hev b 1 and Hev b 3 in latex allergy.
Leiomyomatosis
Morphologic, Molecular, and Taxonomic Evolution of Renal Cell Carcinoma: A Conceptual Perspective With Emphasis on Updates to the 2016 World Health Organization Classification.
Leiomyosarcoma
The Akt/mammalian target of rapamycin pathway is activated and associated with adverse prognosis in soft tissue leiomyosarcomas.
Leishmaniasis
Analysis of the Antigenic and Prophylactic Properties of the Leishmania Translation Initiation Factors eIF2 and eIF2B in Natural and Experimental Leishmaniasis.
Leishmaniasis, Visceral
Induction of protective cellular immune responses against experimental visceral leishmaniasis mediated by dendritic cells pulsed with the N-terminal domain of Leishmania infantum elongation factor-2 and CpG oligodeoxynucleotides.
Leukemia
1,25-Dihydroxyvitamin D3 suppresses gene expression of eukaryotic translation initiation factor 2 in human promyelocytic leukemia HL-60 cells.
Leukemia
4-Amino-2-Trifluoromethyl-Phenyl Retinate induced leukemia cell differentiation by decreasing eIF6.
Leukemia
A lentiviral functional proteomics approach identifies chromatin remodeling complexes important for the induction of pluripotency.
Leukemia
Acute myelogenous leukemia cells with the MLL-ELL translocation convert morphologically and functionally into adherent myofibroblasts.
Leukemia
Asperuloside exhibits a novel anti-leukemic activity by triggering ER stress-regulated apoptosis via targeting GRP78.
Leukemia
Cluster analysis and phylogenetic relationship in biomarker identification of type 2 diabetes and nephropathy.
Leukemia
Dynamic bookmarking of primary response genes by p300 and RNA polymerase II complexes.
Leukemia
EAF1, a novel ELL-associated factor that is delocalized by expression of the MLL-ELL fusion protein.
Leukemia
EIF2A-dependent translational arrest protects leukemia cells from the energetic stress induced by NAMPT inhibition.
Leukemia
ELL binding regulates U19/Eaf2 intracellular localization, stability, and transactivation.
Leukemia
Extended transgene expression from a nonintegrating adenoviral vector containing retroviral elements.
Leukemia
Functional analysis of various promoters in lentiviral vectors at different stages of in vitro differentiation of mouse embryonic stem cells.
Leukemia
Functional interaction between ELL transcription elongation factor and Epe1 reveals the role of Epe1 in the regulation of transcription outside heterochromatin.
Leukemia
Glucocorticoids Induce Cardiac Fibrosis via Mineralocorticoid Receptor in Oxidative Stress: Contribution of Elongation Factor Eleven-Nineteen Lysine-Rich Leukemia (ELL).
Leukemia
Identification of the deleted in liver cancer 1 gene, DLC1, as a candidate meningioma tumor suppressor.
Leukemia
Loss of gene expression in lentivirus- and retrovirus-transduced neural progenitor cells is correlated to migration and differentiation in the adult spinal cord.
Leukemia
Networking of differentially expressed genes in human cancer cells resistant to methotrexate.
Leukemia
Nitrosative stress-induced s-glutathionylation of protein disulfide isomerase leads to activation of the unfolded protein response.
Leukemia
Physical interaction and functional antagonism between the RNA polymerase II elongation factor ELL and p53.
Leukemia
Protein synthesis inhibition by flavonoids: roles of eukaryotic initiation factor 2alpha kinases.
Leukemia
RNA 3' readthrough of oncoretrovirus and lentivirus: implications for vector safety and efficacy.
Leukemia
Taking MLL through the MudPIT: identification of novel complexes that bring together MLL-fusion proteins and transcription elongation factors.
Leukemia
The effect of fludrocortisone on the uterine receptivity partially mediated by ERK1/2-mTOR pathway.
Leukemia
The Eleven-Nineteen Lysine-rich Leukemia gene (ELL2) influences the histone H3 modifications accompanying the shift to secretory Immunoglobulin heavy chain mRNA production.
Leukemia
The elongation factor ELL (eleven-nineteen lysine-rich leukemia) is a selective coregulator for steroid receptor functions.
Leukemia
The induction of G2/M cell-cycle arrest and apoptosis by cucurbitacin E is associated with increased phosphorylation of eIF2alpha in leukemia cells.
Leukemia
The RING domains of the promyelocytic leukemia protein PML and the arenaviral protein Z repress translation by directly inhibiting translation initiation factor eIF4E.
Leukemia
Transcription elongation factor ELL2 drives Ig secretory-specific mRNA production and the unfolded protein response.
Leukemia, Erythroblastic, Acute
Regulation of the utilization of mRNA for eucaryotic elongation factor Tu in Friend erythroleukemia cells.
Leukemia, Erythroblastic, Acute
The stability of mRNA for eucaryotic elongation factor Tu in Friend erythroleukemia cells varies with growth rate.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Puncta intended: connecting the dots between autophagy and cell stress networks.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Regulation of synaptic Rac1 activity, long-term potentiation maintenance, and learning and memory by BCR and ABR Rac GTPase-activating proteins.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Tyrosine phosphorylation of p62dok by p210bcr-abl inhibits RasGAP activity.
Leukemia, Myeloid
Overexpression of the MEN/ELL protein, an RNA polymerase II elongation factor, results in transformation of Rat1 cells with dependence on the lysine-rich region.
Leukemia, Myeloid, Acute
A carboxy-terminal domain of ELL is required and sufficient for immortalization of myeloid progenitors by MLL-ELL.
Leukemia, Myeloid, Acute
Acute myelogenous leukemia cells with the MLL-ELL translocation convert morphologically and functionally into adherent myofibroblasts.
Leukemia, Myeloid, Acute
Conformational changes induced in the eukaryotic translation initiation factor eIF4E by a clinically relevant inhibitor, ribavirin triphosphate.
Leukemia, Myeloid, Acute
Dimethylation of eEF1A at Lysine 55 Plays a Key Role in the Regulation of eEF1A2 on Malignant Cell Functions of Acute Myeloid Leukemia.
Leukemia, Myeloid, Acute
ELL binding regulates U19/Eaf2 intracellular localization, stability, and transactivation.
Leukemia, Myeloid, Acute
ELL2, a new member of an ELL family of RNA polymerase II elongation factors.
Leukemia, Myeloid, Acute
Eukaryotic initiation factor-2, gamma subunit, suppresses proliferation and regulates the cell cycle via the MAPK/ERK signaling pathway in acute myeloid leukemia.
Leukemia, Myeloid, Acute
Identification of a novel RAS GTPase-activating protein (RASGAP) gene at 9q34 as an MLL fusion partner in a patient with de novo acute myeloid leukemia.
Leukemia, Myeloid, Acute
Identification, cloning, expression, and biochemical characterization of the testis-specific RNA polymerase II elongation factor ELL3.
Leukemia, Myeloid, Acute
Importin 8 mediates m7G cap-sensitive nuclear import of the eukaryotic translation initiation factor eIF4E.
Leukemia, Myeloid, Acute
Knockdown of eukaryotic translation initiation factor 3 subunit B inhibits cell proliferation and migration and promotes apoptosis by downregulating WNT signaling pathway in acute myeloid leukemia.
Leukemia, Myeloid, Acute
Knockdown of eukaryotic translation initiation factor 3 subunit D (eIF3D) inhibits proliferation of acute myeloid leukemia cells.
Leukemia, Myeloid, Acute
Merestinib blocks Mnk kinase activity in acute myeloid leukemia progenitors and exhibits antileukemic effects in vitro and in vivo.
Leukemia, Myeloid, Acute
MicroRNA-33b regulates sensitivity to daunorubicin in acute myelocytic leukemia by regulating eukaryotic translation initiation factor 5A-2.
Leukemia, Myeloid, Acute
Molecular targeting of the oncogene eIF4E in AML: a proof-of-principle clinical trial with ribavirin.
Leukemia, Myeloid, Acute
Targeting the oncogene eIF4E in cancer: from the bench to clinical trials.
Leukemia, Myeloid, Acute
The eukaryotic translation initiation factor eIF4E is a direct transcriptional target of NF-?B and is aberrantly regulated in Acute Myeloid Leukemia.
Leukemia, T-Cell
Effects of translation initiation factor eIF-5A on the functioning of human T-cell leukemia virus type I Rex and human immunodeficiency virus Rev inhibited trans dominantly by a Rex mutant deficient in RNA binding.
Leukemia, T-Cell
Structure of translation initiation factor 5A from Pyrobaculum aerophilum at 1.75 A resolution.
Leukemia, T-Cell
[Effect of Knocking down eEF1A1 Gene on Proliferation and Apoptosis in Jurkat Cells and Its Mechanisms].
Leukemia, T-Cell
[Effects of eEF1A1 re-expression on proliferation and apoptosis of Jurkat cells with knocked down eEF1A1 gene and its mechanisms].
Leukoencephalopathies
A Japanese girl with an early-infantile onset vanishing white matter disease resembling Cree leukoencephalopathy.
Leukoencephalopathies
A new function and complexity for protein translation initiation factor eIF2B.
Leukoencephalopathies
A point mutation in translation initiation factor 2B leads to a continuous hyper stress state in oligodendroglial-derived cells.
Leukoencephalopathies
A point mutation in translation initiation factor eIF2B leads to function--and time-specific changes in brain gene expression.
Leukoencephalopathies
A severe variant of childhood ataxia with central hypomyelination/vanishing white matter leukoencephalopathy related to EIF21B5 mutation.
Leukoencephalopathies
A yeast purification system for human translation initiation factors eIF2 and eIF2B? and their use in the diagnosis of CACH/VWM disease.
Leukoencephalopathies
Analysis of eIF2B bodies and their relationships with stress granules and P-bodies.
Leukoencephalopathies
Analysis of the subunit organization of the eIF2B complex reveals new insights into its structure and regulation.
Leukoencephalopathies
Biochemical effects of mutations in the gene encoding the alpha subunit of eukaryotic initiation factor (eIF) 2B associated with Vanishing White Matter disease.
Leukoencephalopathies
Different Eukaryotic Initiation Factor 2B? Mutations Lead to Various Degrees of Intolerance to the Stress of Endoplasmic Reticulum in Oligodendrocytes.
Leukoencephalopathies
Discovery of Chemical Modulators of a Conserved Translational Control Pathway by Parallel Screening in Yeast.
Leukoencephalopathies
EIF2B and Oligodendrocyte Survival: Where Nature and Nurture Meet in Bipolar Disorder and Schizophrenia?
Leukoencephalopathies
eIF2B-related disorders: antenatal onset and involvement of multiple organs.
Leukoencephalopathies
EIF2B2 mutations in vanishing white matter disease hypersuppress translation and delay recovery during the integrated stress response.
Leukoencephalopathies
EIF2B5 mutations compromise GFAP+ astrocyte generation in vanishing white matter leukodystrophy.
Leukoencephalopathies
eIF2B: recent structural and functional insights into a key regulator of translation.
Leukoencephalopathies
Endoplasmic reticulum stress intolerance in EIF2B3 mutant oligodendrocytes is modulated by depressed autophagy.
Leukoencephalopathies
Epstein-Barr and other viral mimicry of autoantigens, myelin and vitamin D-related proteins and of EIF2B, the cause of vanishing white matter disease: massive mimicry of multiple sclerosis relevant proteins by the Synechococcus phage.
Leukoencephalopathies
Expression, purification, and crystallization of Schizosaccharomyces pombe eIF2B.
Leukoencephalopathies
Fifteen Novel EIF2B1-5 Mutations Identified in Chinese Children with Leukoencephalopathy with Vanishing White Matter and a Long Term Follow-Up.
Leukoencephalopathies
Foetal onset of EIF2B related disorder in two siblings: cerebellar hypoplasia with absent Bergmann glia and severe hypomyelination.
Leukoencephalopathies
Functional analysis of recently identified mutations in eukaryotic translation initiation factor 2B? (eIF2B?) identified in Chinese patients with vanishing white matter disease.
Leukoencephalopathies
Glial pathology in a novel spontaneous mutant mouse of the Eif2b5 gene: a vanishing white matter disease model.
Leukoencephalopathies
Hyaluronan accumulation and arrested oligodendrocyte progenitor maturation in vanishing white matter disease.
Leukoencephalopathies
Identification of Intersubunit Domain Interactions within Eukaryotic Initiation Factor (eIF) 2B, the Nucleotide Exchange Factor for Translation Initiation.
Leukoencephalopathies
Identification of novel EIF2B mutations in Chinese patients with vanishing white matter disease.
Leukoencephalopathies
Identification of ten novel mutations in patients with eIF2B-related disorders.
Leukoencephalopathies
Impaired eukaryotic translation initiation factor 2B activity specifically in oligodendrocytes reproduces the pathology of vanishing white matter disease in mice.
Leukoencephalopathies
Leukoencephalopathy with vanishing white matter due to homozygous EIF2B2 gene mutation. First Polish cases.
Leukoencephalopathies
Localization of the Translational Guanine Nucleotide Exchange Factor eIF2B: A Common Theme for GEFs?
Leukoencephalopathies
Modeling vanishing white matter disease with patient-derived induced pluripotent stem cells reveals astrocytic dysfunction.
Leukoencephalopathies
Mutant eIF2B leads to impaired mitochondrial oxidative phosphorylation in vanishing white matter disease.
Leukoencephalopathies
Mutational analysis of the alpha subunit of eIF2B provides insights into the role of eIF2B bodies in translational control and VWM disease.
Leukoencephalopathies
Mutations causing childhood ataxia with central nervous system hypomyelination reduce eukaryotic initiation factor 2B complex formation and activity.
Leukoencephalopathies
Mutations in each of the five subunits of translation initiation factor eIF2B can cause leukoencephalopathy with vanishing white matter.
Leukoencephalopathies
Mutations in the genes encoding eukaryotic translation initiation factor 2B in Japanese patients with vanishing white matter disease.
Leukoencephalopathies
Novel mutation in EIF2B gene in a case of adult-onset leukoencephalopathy with vanishing white matter.
Leukoencephalopathies
Novel mutation in mitochondrial Elongation Factor EF-Tu associated to dysplastic leukoencephalopathy and defective mitochondrial DNA translation.
Leukoencephalopathies
Novel mutations identified in EIF2B5 gene in Kashmiri patients as susceptibility factor for multiple sclerosis.
Leukoencephalopathies
Paradoxical Sensitivity to an Integrated Stress Response Blocking Mutation in Vanishing White Matter Cells.
Leukoencephalopathies
Poor cerebral inflammatory response in eIF2B knock-in mice: implications for the aetiology of vanishing white matter disease.
Leukoencephalopathies
Profile of Indian Children with Childhood Ataxia and Central Nervous System Hypomyelination/Vanishing White Matter Disease: A Single Center Experience from Southern India.
Leukoencephalopathies
Role of Saccharomyces cerevisiae TAN1 (tRNA acetyltransferase) in eukaryotic initiation factor 2B (eIF2B)-mediated translation control and stress response.
Leukoencephalopathies
Saccharomyces cerevisiae ER membrane protein complex subunit 4 (EMC4) plays a crucial role in eIF2B-mediated translation regulation and survival under stress conditions.
Leukoencephalopathies
Severity of Vanishing White Matter disease does not correlate with deficits in eIF2B activity or the integrity of eIF2B complexes.
Leukoencephalopathies
Subunits of the translation initiation factor eIF2B are mutant in leukoencephalopathy with vanishing white matter.
Leukoencephalopathies
The Energy Status of Astrocytes Is the Achilles' Heel of eIF2B-Leukodystrophy.
Leukoencephalopathies
The life and death of oligodendrocytes in vanishing white matter disease.
Leukoencephalopathies
The small molecule ISRIB rescues the stability and activity of Vanishing White Matter Disease eIF2B mutant complexes.
Leukoencephalopathies
The spectrum of mutations for the diagnosis of vanishing white matter disease.
Leukoencephalopathies
Vanishing white matter disease in French-Canadian patients from Quebec.
Leukoencephalopathies
Vanishing white matter disease presenting as opsoclonus myoclonus syndrome in childhood--a case report and review of the literature.
Leukoencephalopathies
Vanishing white matter disease with a novel EIF2B5 mutation: A 10-year follow-up.
Leukoencephalopathies
[Advances in functional study of EIF2B mutations in leukoencephalopathy with vanishing white matter].
Leukoencephalopathies
[Eukaryotic translation initiation factor 2B and leukoencephalopathy with vanishing white matter.]
Lewy Body Disease
Sequence variants in eukaryotic translation initiation factor 4-gamma (eIF4G1) are associated with Lewy body dementia.
Lipodystrophy
Protein Arginine Methyltransferase PRMT5 Regulates Fatty Acid Metabolism and Lipid Droplet Biogenesis in White Adipose Tissues.
Lipodystrophy, Congenital Generalized
Protein Arginine Methyltransferase PRMT5 Regulates Fatty Acid Metabolism and Lipid Droplet Biogenesis in White Adipose Tissues.
Liver Diseases
Levels of Hepatic Activating Transcription Factor 6 and Caspase-3 Are Downregulated in Mice after Excessive Training.
Liver Diseases
Lipotoxicity-induced STING1 activation stimulates MTORC1 and restricts hepatic lipophagy.
Liver Diseases
The marine compound and elongation factor 1A1 inhibitor, didemnin B, provides benefit in western diet-induced non-alcoholic fatty liver disease.
Liver Diseases
The unfolded protein response regulates hepatic autophagy by sXBP1-mediated activation of TFEB.
Liver Failure
Mutation in the mitochondrial translation elongation factor EFTs results in severe infantile liver failure.
Liver Neoplasms
Deleted in liver cancer (DLC) 2 encodes a RhoGAP protein with growth suppressor function and is underexpressed in hepatocellular carcinoma.
Liver Neoplasms
Deleted in Liver Cancer 1 (DLC1) Utilizes a Novel Binding Site for Tensin2 PTB Domain Interaction and Is Required for Tumor-Suppressive Function.
Liver Neoplasms
Deleted in liver cancer 2 (DLC2) was dispensable for development and its deficiency did not aggravate hepatocarcinogenesis.
Liver Neoplasms
Deleted in liver cancer 2 suppresses cell growth via the regulation of the Raf-1-ERK1/2-p70S6K signalling pathway.
Liver Neoplasms
Deleted in liver cancer 3 (DLC-3), a novel Rho GTPase-activating protein, is downregulated in cancer and inhibits tumor cell growth.
Liver Neoplasms
DLC-1, a Rho GTPase-activating protein with tumor suppressor function, is essential for embryonic development.
Liver Neoplasms
DLC1 Activation Requires Lipid Interaction through a Polybasic Region Preceding the RhoGAP Domain.
Liver Neoplasms
Dlc1 interaction with non-muscle myosin heavy chain II-A (Myh9) and Rac1 activation.
Liver Neoplasms
DLC3 suppresses MT1-MMP-dependent matrix degradation by controlling RhoB and actin remodeling at endosomal membranes.
Liver Neoplasms
Epidermal Growth Factor Activates the Rho GTPase-activating Protein (GAP) Deleted in Liver Cancer 1 via Focal Adhesion Kinase and Protein Phosphatase 2A.
Liver Neoplasms
Expression of eukaryotic translation initiation factor 3 subunit B in liver cancer and its prognostic significance.
Liver Neoplasms
Identification of p122RhoGAP (Deleted in Liver Cancer-1) Serine 322 as a Substrate for Protein Kinase B and Ribosomal S6 Kinase in Insulin-stimulated Cells.
Liver Neoplasms
Loss of DLC1 is an independent prognostic factor in patients with oral squamous cell carcinoma.
Liver Neoplasms
Nuclear DLC1 exerts oncogenic function through association with FOXK1 for cooperative activation of MMP9 expression in melanoma.
Liver Neoplasms
Oncogenic inhibition by a deleted in liver cancer gene requires cooperation between tensin binding and Rho-specific GTPase-activating protein activities.
Liver Neoplasms
p120Ras-GAP binds the DLC1 Rho-GAP tumor suppressor protein and inhibits its RhoA GTPase and growth-suppressing activities.
Liver Neoplasms
Rho GTPase-activating protein deleted in liver cancer suppresses cell proliferation and invasion in hepatocellular carcinoma.
Liver Neoplasms
Scaffolding Protein IQGAP1 Is Dispensable, but Its Overexpression Promotes Hepatocellular Carcinoma via YAP1 Signaling.
Liver Neoplasms
Silencing of DLC1 upregulates PAI-1 expression and reduces migration in normal prostate cells.
Liver Neoplasms
The intracellular stability of DLC1 is regulated by the 26S proteasome in human hepatocellular carcinoma cell line Hep3B.
Liver Neoplasms
The RhoA GTPase-Activating Protein DLC2 Modulates RhoA Activity and Hyperalgesia to Noxious Thermal and Inflammatory Stimuli.
Liver Neoplasms
The translation initiation factor eIF3i up-regulates vascular endothelial growth factor A, accelerates cell proliferation, and promotes angiogenesis in embryonic development and tumorigenesis.
Liver Neoplasms
The tumor suppressor protein DLC1 maintains protein kinase D activity and Golgi secretory function.
Liver Neoplasms
Uncovering the rare variants of DLC1 isoform 1 and their functional effects in a Chinese sporadic congenital heart disease cohort.
Lung Neoplasms
Adenoviral transfer of the melanoma differentiation-associated gene 7 (mda7) induces apoptosis of lung cancer cells via up-regulation of the double-stranded RNA-dependent protein kinase (PKR).
Lung Neoplasms
Aerosol delivery of eukaryotic translation initiation factor 4E-binding protein 1 effectively suppresses lung tumorigenesis in K-rasLA1 mice.
Lung Neoplasms
Antibiotic drug rifabutin is effective against lung cancer cells by targeting the eIF4E-?-catenin axis.
Lung Neoplasms
Antisense oligonucleotide targeting eukaryotic translation initiation factor 4E reduces growth and enhances chemosensitivity of non-small-cell lung cancer cells.
Lung Neoplasms
ARHGAP24 inhibits cell proliferation and cell cycle progression and induces apoptosis of lung cancer via a STAT6-WWP2-P27 axis.
Lung Neoplasms
Association of positively selected eIF3a polymorphisms with toxicity of platinum-based chemotherapy in NSCLC patients.
Lung Neoplasms
C-Raf antagonizes apoptosis induced by IFN-alpha in human lung cancer cells by phosphorylation and increase of the intracellular content of elongation factor 1A.
Lung Neoplasms
CGP57380 enhances efficacy of RAD001 in non-small cell lung cancer through abrogating mTOR inhibition-induced phosphorylation of eIF4E and activating mitochondrial apoptotic pathway.
Lung Neoplasms
Cisplatin sensitivity is enhanced in non-small cell lung cancer cells by regulating epithelial-mesenchymal transition through inhibition of eukaryotic translation initiation factor 5A2.
Lung Neoplasms
Clinical value of eukaryotic elongation factor 2 (eEF2) in non-small cell lung cancer patients.
Lung Neoplasms
Coexpression of IQ-domain GTPase-activating protein 1 (IQGAP1) and Dishevelled (Dvl) is correlated with poor prognosis in non-small cell lung cancer.
Lung Neoplasms
CRL4A-FBXW5-mediated degradation of DLC1 Rho GTPase-activating protein tumor suppressor promotes non-small cell lung cancer cell growth.
Lung Neoplasms
Effect of docetaxel on expression of eIF3a in human lung cancer A549 cell line.
Lung Neoplasms
eIF5B drives integrated stress response-dependent translation of PD-L1 in lung cancer.
Lung Neoplasms
Elevated expression of eukaryotic translation initiation factor 4E is associated with proliferation, invasion and acquired resistance to erlotinib in lung cancer.
Lung Neoplasms
Elevation of EIF4G1 promotes non-small cell lung cancer progression by activating mTOR signalling.
Lung Neoplasms
Eukaryotic translation initiation factor 3 subunit C is associated with acquired resistance to erlotinib in non-small cell lung cancer.
Lung Neoplasms
High WBP5 expression correlates with elevation of HOX genes levels and is associated with inferior survival in patients with acute myeloid leukaemia.
Lung Neoplasms
HSP90/AXL/eIF4E-regulated unfolded protein response as an acquired vulnerability in drug-resistant KRAS-mutant lung cancer.
Lung Neoplasms
Independent overexpression of the subunits of translation elongation factor complex eEF1H in human lung cancer.
Lung Neoplasms
Influence of eukaryotic translation initiation factor 6 on non-small cell lung cancer development and progression.
Lung Neoplasms
LC-MS/MS-Based Quantitative Proteomics Analysis of Different Stages of Non-Small-Cell Lung Cancer.
Lung Neoplasms
MicroRNA-9 Enhanced Cisplatin Sensitivity in Nonsmall Cell Lung Cancer Cells by Regulating Eukaryotic Translation Initiation Factor 5A2.
Lung Neoplasms
MicroRNA-9 regulates non-small cell lung cancer cell invasion and migration by targeting eukaryotic translation initiation factor 5A2.
Lung Neoplasms
MiR-488 inhibits proliferation and cisplatin sensibility in non-small-cell lung cancer (NSCLC) cells by activating the eIF3a-mediated NER signaling pathway.
Lung Neoplasms
MYC and EIF3H Coamplification significantly improve response and survival of non-small cell lung cancer patients (NSCLC) treated with gefitinib.
Lung Neoplasms
N1-guanyl-1,7-diaminoheptane enhances the chemosensitivity of NSCLC cells to cetuximab through inhibition of eukaryotic translation initiation factor 5A2 activation.
Lung Neoplasms
Nannocystin Ax, a natural elongation factor 1? inhibitor from Nannocystis sp., suppresses epithelial-mesenchymal transition, adhesion and migration in lung cancer cells.
Lung Neoplasms
Nuclear control of lung cancer cells migration, invasion and bioenergetics by eukaryotic translation initiation factor 3F.
Lung Neoplasms
Overexpression of eukaryotic translation initiation factor 4E-binding protein 1 induces the alteration of immune status in H1299 lung cancer cells.
Lung Neoplasms
Pim-1 kinase is a target of miR-486-5p and eukaryotic translation initiation factor 4E, and plays a critical role in lung cancer.
Lung Neoplasms
RNA binding motif protein 10 suppresses lung cancer progression by controlling alternative splicing of eukaryotic translation initiation factor 4H.
Lung Neoplasms
Role of EIF4G1 network in non-small cell lung cancers (NSCLC) cell survival and disease progression.
Lung Neoplasms
The anti-cancer drug ABTL0812 induces ER stress-mediated cytotoxic autophagy by increasing dihydroceramide levels in cancer cells.
Lung Neoplasms
The expression of eukaryotic translation initiation factor 3B and its correlation with tumor characteristics as well as prognosis in non-small cell lung cancer patients: a retrospective study.
Lung Neoplasms
The prognostic significance of eukaryotic elongation factor 1 alpha-2 in non-small cell lung cancer.
Lung Neoplasms
Tumor suppressor gene 14-3-3sigma is down-regulated whereas the proto-oncogene translation elongation factor 1delta is up-regulated in non-small cell lung cancers as identified by proteomic profiling.
Lung Neoplasms
Two subcellular localizations of eIF3 p170 and its interaction with membrane-bound microfilaments: implications for alternative functions of p170.
Lung Neoplasms
Yap-Hippo promotes A549 lung cancer cell death via modulating MIEF1-related mitochondrial stress and activating JNK pathway.
Lyme Disease
Borrelia burgdorferi elongation factor EF-Tu is an immunogenic protein during Lyme borreliosis.
Lymphatic Metastasis
Eukaryotic translation initiation factor 3B is overexpressed and correlates with higher FIGO stage III/IV, lymph node metastasis and unfavorable survival profiles in cervical cancer patients.
Lymphatic Metastasis
IQ-domain GTPase-activating protein 1 promotes the malignant phenotype of invasive ductal breast carcinoma via canonical Wnt pathway.
Lymphoma
Concurrent inhibition of PI3-Kinase and mTOR induces cell death in diffuse large B cell lymphomas, a mechanism involving down regulation of Mcl-1.
Lymphoma
Infection of human B lymphoma cells by Mycoplasma fermentans induces interaction of its elongation factor with the intracytoplasmic domain of Epstein-Barr virus receptor (gp140, EBV/C3dR, CR2, CD21).
Lymphoma
Morphologic, Molecular, and Taxonomic Evolution of Renal Cell Carcinoma: A Conceptual Perspective With Emphasis on Updates to the 2016 World Health Organization Classification.
Lymphoma, B-Cell
Concurrent inhibition of PI3-Kinase and mTOR induces cell death in diffuse large B cell lymphomas, a mechanism involving down regulation of Mcl-1.
Lymphoma, B-Cell
Expression and Phosphorylation of Eukaryotic Translation Initiation Factor 4E Binding Protein 1 in B-Cell Lymphomas and Reactive Lymphoid Tissues.
Lymphoma, B-Cell
Expression profile of translation initiation factor eIF2B5 in diffuse large B-cell lymphoma and its correlation to clinical outcome.
Lymphoma, B-Cell
Pathogenicity and virulence of Japanese encephalitis virus: Neuroinflammation and neuronal cell damage.
Lymphoma, B-Cell
Ran GTPase-activating protein 1 is a therapeutic target in diffuse large B-cell lymphoma.
Lymphoma, B-Cell
Rutin hydrate inhibits apoptosis in the brains of cadmium chloride-treated rats via preserving the mitochondrial integrity and inhibiting endoplasmic reticulum stress.
Lymphoma, Follicular
FilGAP, a Rac-specific Rho GTPase-activating protein, is a novel prognostic factor for follicular lymphoma.
Lymphoma, Large B-Cell, Diffuse
Concurrent inhibition of PI3-Kinase and mTOR induces cell death in diffuse large B cell lymphomas, a mechanism involving down regulation of Mcl-1.
Lymphoma, Large B-Cell, Diffuse
Expression profile of translation initiation factor eIF2B5 in diffuse large B-cell lymphoma and its correlation to clinical outcome.
Lymphoma, Large B-Cell, Diffuse
Ran GTPase-activating protein 1 is a therapeutic target in diffuse large B-cell lymphoma.
Lymphoma, Non-Hodgkin
Relationship between eukaryotic translation initiation factor 4E and malignant angiogenesis in non-Hodgkin lymphoma.
Macular Degeneration
Molecular cloning of ELOVL4 gene from cynomolgus monkey (Macaca fascicularis).
Malaria
Biliverdin targets enolase and eukaryotic initiation factor 2 (eIF2?) to reduce the growth of intraerythrocytic development of the malaria parasite Plasmodium falciparum.
Malaria
Characterization of two malaria parasite organelle translation elongation factor g proteins: the likely targets of the anti-malarial fusidic acid.
Malaria
Histamine releasing factor and elongation factor 1 alpha secreted via malaria parasites extracellular vesicles promote immune evasion by inhibiting specific T cell responses.
Malaria
Malaria parasites contain two identical copies of an elongation factor 1 alpha gene.
Malaria
Malaria parasites lacking eef1a have a normal S/M phase yet grow more slowly due to a longer G1 phase.
Malaria
Structural and mechanistic insights into the action of Plasmodium falciparum spermidine synthase.
Malnutrition
Lactase synthesis is pretranslationally regulated in protein-deficient pigs fed a protein-sufficient diet.
Malocclusion
MTORC1 coordinates the autophagy and apoptosis signaling in articular chondrocytes in osteoarthritic temporomandibular joint.
Mandibulofacial Dysostosis
Investigation of Genetic Causes in a Developmental Disorder: Oculoauriculovertebral Spectrum.
Mandibulofacial Dysostosis
Novel De Novo EFTUD2 Mutations in 2 Cases With MFDM, Initially Suspected to Have Alternative Craniofacial Diagnoses.
Mandibulofacial Dysostosis
Novel Splice Site Pathogenic Variant of EFTUD2 Is Associated with Mandibulofacial Dysostosis with Microcephaly and Extracranial Symptoms in Korea.
Medulloblastoma
Medulloblastoma outcome is adversely associated with overexpression of EEF1D, RPL30, and RPS20 on the long arm of chromosome 8.
Melanoma
Activated G(alpha)13 impairs cell invasiveness through p190RhoGAP-mediated inhibition of RhoA activity.
Melanoma
Decreased proliferation of human melanoma cell lines caused by antisense RNA against translation factor eIF-4A1.
Melanoma
Discrimination of melanocytic tumors by cDNA array hybridization of tissues prepared by laser pressure catapulting.
Melanoma
eIF4E Is an Adverse Prognostic Marker of Melanoma Patient Survival by Increasing Melanoma Cell Invasion.
Melanoma
Human elongation factor 1 alpha: a polymorphic and conserved multigene family with multiple chromosomal localizations.
Melanoma
Identification of novel proteins associated with the development of chemoresistance in malignant melanoma using two-dimensional electrophoresis.
Melanoma
Inhibition of eukaryotic translation initiation factor 5A (eIF5A) hypusination impairs melanoma growth.
Melanoma
Investigation of the eIF2alpha phosphorylation mechanism in response to proteasome inhibition in melanoma and breast cancer cells.
Melanoma
Knockdown of EIF3D suppresses proliferation of human melanoma cells through G2/M phase arrest.
Melanoma
MD11-mediated delivery of recombinant eIF3f induces melanoma and colorectal carcinoma cell death.
Melanoma
Neoplastic progression in melanoma and colon cancer is associated with increased expression and activity of the interferon-inducible protein kinase, PKR.
Melanoma
Nuclear DLC1 exerts oncogenic function through association with FOXK1 for cooperative activation of MMP9 expression in melanoma.
Melanoma
Prognostic significance of the expression of nuclear eukaryotic translation initiation factor 5A2 in human melanoma.
Melanoma
Regulation of endoplasmic reticulum stress-induced cell death by ATF4 in neuroectodermal tumor cells.
Melanoma
Targeting of eEF1A with Amaryllidaceae isocarbostyrils as a strategy to combat melanomas.
Melanoma
Transcription elongation factor A-like 7, regulated by miR-758-3p inhibits the progression of melanoma through decreasing the expression levels of c-Myc and AKT1.
Melanoma
Translation initiation factor eIF-4A1 mRNA is consistently overexpressed in human melanoma cells in vitro.
Melanoma
Translation reprogramming is an evolutionarily conserved driver of phenotypic plasticity and therapeutic resistance in melanoma.
Melanoma
Tumor suppression by PTEN requires the activation of the PKR-eIF2alpha phosphorylation pathway.
Melanoma
Tumor suppressor and growth regulatory genes are overexpressed in severe early-onset preeclampsia--an array study on case-specific human preeclamptic placental tissue.
Memory Disorders
Activation of the ISR mediates the behavioral and neurophysiological abnormalities in Down syndrome.
Meningioma
Eukaryotic Initiation Factors (eIF) 2{alpha} and 4E Expression, Localization, and Phosphorylation in Brain Tumors.
Meningioma
Identification of the deleted in liver cancer 1 gene, DLC1, as a candidate meningioma tumor suppressor.
Meningioma
Overexpression of eIF4F components in meningiomas and suppression of meningioma cell growth by inhibiting translation initiation.
Meningitis
CSF Levels of Elongation Factor Tu Is Associated With Increased Mortality in Malawian Adults With Streptococcus pneumoniae Meningitis.
Meningitis, Pneumococcal
CSF Levels of Elongation Factor Tu Is Associated With Increased Mortality in Malawian Adults With Streptococcus pneumoniae Meningitis.
Mental Retardation, X-Linked
Oligophrenin-1, a Rho GTPase-activating protein (RhoGAP) involved in X-linked mental retardation, is expressed in the enteric nervous system.
Metabolic Syndrome
Metabolic effects of RUBCN/Rubicon deficiency in kidney proximal tubular epithelial cells.
Metrorrhagia
The pleiotropic mouse phenotype extra-toes spotting is caused by translation initiation factor Eif3c mutations and is associated with disrupted sonic hedgehog signaling.
Microcephaly
Homozygous mutation in the eukaryotic translation initiation factor 2alpha phosphatase gene, PPP1R15B, is associated with severe microcephaly, short stature and intellectual disability.
Microcephaly
Investigation of Genetic Causes in a Developmental Disorder: Oculoauriculovertebral Spectrum.
Microcephaly
Novel De Novo EFTUD2 Mutations in 2 Cases With MFDM, Initially Suspected to Have Alternative Craniofacial Diagnoses.
Microcephaly
Novel Splice Site Pathogenic Variant of EFTUD2 Is Associated with Mandibulofacial Dysostosis with Microcephaly and Extracranial Symptoms in Korea.
Microphthalmos
Cloning and characterization of a novel rho-type GTPase-activating protein gene (ARHGAP6) from the critical region for microphthalmia with linear skin defects.
Mitochondrial Diseases
Clinical and molecular findings in a family expressing a novel heterozygous variant of the G elongation factor mitochondrial 1 gene.
Mitochondrial Diseases
Mutant mitochondrial elongation factor G1 and combined oxidative phosphorylation deficiency.
Mouth Neoplasms
Biological tailoring of adjuvant radiotherapy in head and neck and oral malignancies - The potential role of p53 and eIF4E as predictive parameters.
Multiple Myeloma
Bevacizumab attenuates major signaling cascades and eIF4E translation initiation factor in multiple myeloma cells.
Multiple Myeloma
Elevated Translation Initiation Factor eIF4E Is an Attractive Therapeutic Target in Multiple Myeloma.
Multiple Myeloma
Inhibition of eIF2alpha dephosphorylation inhibits ErbB2-induced deregulation of mammary acinar morphogenesis.
Multiple Myeloma
Inhibition of eIF2alpha dephosphorylation maximizes bortezomib efficiency and eliminates quiescent multiple myeloma cells surviving proteasome inhibitor therapy.
Multiple Myeloma
Multiple myeloma cells promote migration of bone marrow mesenchymal stem cells by altering their translation initiation.
Multiple Myeloma
Multiple myeloma proteostasis can be targeted via translation initiation factor eIF4E.
Multiple Myeloma
Positive transcription elongation factor b (P-TEFb) is a therapeutic target in human multiple myeloma.
Multiple Myeloma
Synergistic apoptosis induction in leukemic cells by the phosphatase inhibitor salubrinal and proteasome inhibitors.
Multiple Myeloma
Targeting eIF4GI translation initiation factor affords an attractive therapeutic strategy in multiple myeloma.
Multiple Myeloma
The PP242 mammalian target of rapamycin (mTOR) inhibitor activates extracellular signal-regulated kinase (ERK) in multiple myeloma cells via a target of rapamycin complex 1 (TORC1)/eukaryotic translation initiation factor 4E (eIF-4E)/RAF pathway and activation is a mechanism of resistance.
Multiple Myeloma
Translation initiation factor eIF4F modifies the dexamethasone response in multiple myeloma.
Multiple Sclerosis
Arg113His mutation of vanishing white matter is not present in multiple sclerosis.
Multiple Sclerosis
Epstein-Barr and other viral mimicry of autoantigens, myelin and vitamin D-related proteins and of EIF2B, the cause of vanishing white matter disease: massive mimicry of multiple sclerosis relevant proteins by the Synechococcus phage.
Murine Acquired Immunodeficiency Syndrome
Analysis of antigen receptor signaling in B cells from mice with a retrovirus-induced acquired immunodeficiency syndrome.
Muscle Cramp
Proteins induced by telomere dysfunction and DNA damage represent biomarkers of human aging and disease.
Muscle Hypotonia
Mild epileptic phenotype associates with de novo eef1a2 mutation: Case report and review.
Muscular Atrophy
Are tumoral factors responsible for host tissue wasting in cancer cachexia?
Muscular Atrophy
Cdc42 GTPase-activating protein deficiency promotes genomic instability and premature aging-like phenotypes.
Muscular Atrophy
Effect of branched-chain amino acid supplementation during unloading on regulatory components of protein synthesis in atrophied soleus muscles.
Muscular Atrophy
In vivo characterization of the role of tissue-specific translation elongation factor 1A2 in protein synthesis reveals insights into muscle atrophy.
Muscular Atrophy
Muscle atrophy and hypertrophy signaling in patients with chronic obstructive pulmonary disease.
Muscular Atrophy
Regulation of contractile proteins and protein translational signaling in disused muscle.
Muscular Atrophy
The initiation factor eIF3-f is a major target for atrogin1/MAFbx function in skeletal muscle atrophy.
Muscular Diseases
In vivo characterization of the role of tissue-specific translation elongation factor 1A2 in protein synthesis reveals insights into muscle atrophy.
Muscular Dystrophy, Duchenne
WWP, a new amino acid motif present in single or multiple copies in various proteins including dystrophin and the SH3-binding Yes-associated protein YAP65.
Myelodysplastic Syndromes
Ras-proximate-1 GTPase-activating protein and Rac2 may play pivotal roles in the initial development of myelodysplastic syndrome.
Myeloproliferative Disorders
Increased c-Myc activity and DNA damage in hematopoietic progenitors precede myeloproliferative disease in Spa-1-deficiency.
Myocardial Infarction
Salubrinal protects cardiomyocytes against apoptosis in a rat myocardial infarction model via suppressing the dephosphorylation of eukaryotic translation initiation factor 2?.
Myocardial Ischemia
Heat shock protein 70 protects cardiomyocytes through suppressing SUMOylation and nucleus translocation of phosphorylated eukaryotic elongation factor 2 during myocardial ischemia and reperfusion.
Myocardial Ischemia
Myocardial ischemia and increased heart work modulate the phosphorylation state of eukaryotic elongation factor-2.
Myositis
Identification of a novel autoantigen eukaryotic initiation factor 3 associated with polymyositis.
Myotonic Dystrophy
The alternative initiation factor eIF2A plays key role in RAN translation of myotonic dystrophy type 2 CCUGCAGG repeats.
Myxoma
Myxoma virus immunomodulatory protein M156R is a structural mimic of eukaryotic translation initiation factor eIF2alpha.
Nasal Polyps
Expression of MicroRNA machinery proteins in different types of chronic rhinosinusitis.
Nasopharyngeal Carcinoma
Over-expression of eukaryotic translation initiation factor 4 gamma 1 correlates with tumor progression and poor prognosis in nasopharyngeal carcinoma.
Nasopharyngeal Carcinoma
p53, MDM2, eIF4E and EGFR expression in nasopharyngeal carcinoma and their correlation with clinicopathological characteristics and prognosis: A retrospective study.
Nasopharyngeal Carcinoma
Ribavirin sensitizes nasopharyngeal carcinoma to 5-fluorouracil through suppressing 5-fluorouracil-induced ERK-dependent-eIF4E activation.
Nasopharyngeal Carcinoma
Suppression of oncogenic protein translation via targeting eukaryotic translation initiation factor 4E overcomes chemo-resistance in nasopharyngeal carcinoma.
Nasopharyngeal Carcinoma
The DLC-1 -29A/T polymorphism is not associated with nasopharyngeal carcinoma risk in Chinese population.
Nasopharyngeal Carcinoma
[Over-expressions of p-eIF4E and p-4EBP1 are associated with poor prognosis in nasopharyngeal carcinoma].
Neoplasm Metastasis
Clusterin facilitates metastasis by EIF3I/Akt/MMP13 signaling in hepatocellular carcinoma.
Neoplasm Metastasis
Commitment of Scaffold Proteins in the Onco-Biology of Human Colorectal Cancer and Liver Metastases after Oxaliplatin-Based Chemotherapy.
Neoplasm Metastasis
Comparative protein profiling identifies elongation factor-1beta and tryparedoxin peroxidase as factors associated with metastasis in Leishmania guyanensis.
Neoplasm Metastasis
Correlation of pterygium severity with IQ-domain GTPase-activating protein 1 (IQGAP1) and mast cells.
Neoplasm Metastasis
DAB2IP regulates EMT and metastasis of prostate cancer through targeting PROX1 transcription and destabilizing HIF1? protein.
Neoplasm Metastasis
Development of Biochemical Assays for the Identification of eIF4E-Specific Inhibitors.
Neoplasm Metastasis
Discrimination of melanocytic tumors by cDNA array hybridization of tissues prepared by laser pressure catapulting.
Neoplasm Metastasis
Downregulation of eukaryotic translation initiation factor 3b inhibited proliferation and metastasis of gastric cancer.
Neoplasm Metastasis
Downregulation of Ral GTPase-activating protein promotes tumor invasion and metastasis of bladder cancer.
Neoplasm Metastasis
EIF5A regulates proliferation and chemoresistance in pancreatic cancer through the sHH signalling pathway.
Neoplasm Metastasis
EIF5A2 is highly expressed in anaplastic thyroid carcinoma and is associated with tumor growth by modulating TGF-? signals.
Neoplasm Metastasis
Elevated levels of p-Mnk1, p-eIF4E and p-p70S6K proteins are associated with tumor recurrence and poor prognosis in astrocytomas.
Neoplasm Metastasis
Eukaryotic translation initiation factor 3B is overexpressed and correlates with higher FIGO stage III/IV, lymph node metastasis and unfavorable survival profiles in cervical cancer patients.
Neoplasm Metastasis
Eukaryotic Translation Initiation Factor 4 Gamma 1 (eIF4G1) is upregulated during Prostate cancer progression and modulates cell growth and metastasis.
Neoplasm Metastasis
Eukaryotic Translation Initiation Factor 5A (EIF5A) Regulates Pancreatic Cancer Metastasis by Modulating RhoA and Rho-associated Kinase (ROCK) Protein Expression Levels.
Neoplasm Metastasis
Eukaryotic translation initiation factor 5A2 regulates the migration and invasion of hepatocellular carcinoma cells via pathways involving reactive oxygen species.
Neoplasm Metastasis
Expression of TBC1D16 Is Associated with Favorable Prognosis of Epithelial Ovarian Cancer.
Neoplasm Metastasis
Expression of total and phospho 4EBP1 in metastatic and non-metastatic renal cell carcinoma.
Neoplasm Metastasis
FGF19/FGFR4 signaling axis confines and switches the role of melatonin in head and neck cancer metastasis.
Neoplasm Metastasis
G3BP1 activates the TGF-?/Smad signaling pathway to promote gastric cancer.
Neoplasm Metastasis
Genetic and Pharmacologic Inhibition of eIF4E Reduces Breast Cancer Cell Migration, Invasion, and Metastasis.
Neoplasm Metastasis
Interaction of the Ras-related protein associated with diabetes rad and the putative tumor metastasis suppressor NM23 provides a novel mechanism of GTPase regulation.
Neoplasm Metastasis
Involvement of Ras GTPase-activating protein SH3 domain-binding protein 1 in the epithelial-to-mesenchymal transition-induced metastasis of breast cancer cells via the Smad signaling pathway.
Neoplasm Metastasis
IQGAP1 Is Involved in Enhanced Aggressive Behavior of Epithelial Ovarian Cancer Stem Cell-Like Cells During Differentiation.
Neoplasm Metastasis
Kisspeptin inhibits cancer growth and metastasis via activation of EIF2AK2.
Neoplasm Metastasis
Lentiviral vector mediated-ASAP1 expression promotes epithelial to mesenchymal transition in ovarian cancer cells.
Neoplasm Metastasis
Loss of G3BP1 suppresses proliferation, migration, and invasion of esophageal cancer cells via Wnt/?-catenin and PI3K/AKT signaling pathways.
Neoplasm Metastasis
MAP4K3/GLK promotes lung cancer metastasis by phosphorylating and activating IQGAP1.
Neoplasm Metastasis
MicroRNA-216a inhibits the growth and metastasis of oral squamous cell carcinoma by targeting eukaryotic translation initiation factor 4B.
Neoplasm Metastasis
MicroRNA?875?5p inhibits tumor growth and metastasis of hepatocellular carcinoma by targeting eukaryotic translation initiation factor 3 subunit a.
Neoplasm Metastasis
Parthenolide reduces metastasis by inhibition of vimentin expression and induces apoptosis by suppression elongation factor ??-?1 expression.
Neoplasm Metastasis
PERK-Phosphorylated eIF2? Pathway Suppresses Tumor Metastasis Through Downregulating Expression of Programmed Death Ligand 1 and CXCL5 in Triple-Negative Breast Cancer.
Neoplasm Metastasis
Phosphorylated Mnk1 and eIF4E are associated with lymph node metastasis and poor prognosis of nasopharyngeal carcinoma.
Neoplasm Metastasis
Phosphorylation of eIF4E promotes EMT and metastasis via translational control of SNAIL and MMP-3.
Neoplasm Metastasis
Prognostic significance of RACGAP1 mRNA expression in high-risk early breast cancer: a study in primary tumors of breast cancer patients participating in a randomized Hellenic Cooperative Oncology Group trial.
Neoplasm Metastasis
RacGAP1 expression, increasing tumor malignant potential, as a predictive biomarker for lymph node metastasis and poor prognosis in colorectal cancer.
Neoplasm Metastasis
Re: Downregulation of Ral GTPase-Activating Protein Promotes Tumor Invasion and Metastasis of Bladder Cancer.
Neoplasm Metastasis
Slit-Robo GTPase-Activating Protein 2 as a metastasis suppressor in osteosarcoma.
Neoplasm Metastasis
Targeting of protein translation as a new treatment paradigm for prostate cancer.
Neoplasm Metastasis
The deubiquitinating enzyme ATXN3 promotes the progression of anaplastic thyroid carcinoma by stabilizing EIF5A2.
Neoplasm Metastasis
The lethal prune/Killer-of-prune interaction of Drosophila causes a syndrome resembling human neurofibromatosis (NF1).
Neoplasm Metastasis
The N-Terminal Domain of G3BP Enhances Cell Motility and Invasion by Posttranscriptional Regulation of BART.
Neoplasm Metastasis
Therapeutic inhibition of MAP kinase interacting kinase blocks eukaryotic initiation factor 4E phosphorylation and suppresses outgrowth of experimental lung metastases.
Neoplasm Metastasis
[Eukaryotic translation elongation factor 1A1 positively regulates NOB1 expression to promote invasion and metastasis of hepatocellular carcinoma cells in vitro].
Neoplasm Metastasis
[Expression and its clinical significance of eIF4E in non-small cell lung cancer].
Neoplasms
4EBP1/eIF4E and p70S6K/RPS6 axes play critical and distinct roles in hepatocarcinogenesis driven by AKT and N-Ras proto-oncogenes in mice.
Neoplasms
A cell-penetrant lactam-stapled peptide for targeting eIF4E protein-protein interactions.
Neoplasms
A comparison between histological grade and nuclear morphometry for predicting the clinical outcome of localized renal cell carcinoma.
Neoplasms
A deficiency or an excess of dietary threonine level affects weight gain, enzyme activity, immune response and immune-related gene expression in juvenile blunt snout bream (Megalobrama amblycephala).
Neoplasms
A GDP/GTP exchange factor essential for eukaryotic initiation factor 2 cycling in Ehrlich ascites tumor cells and its regulation by eukaryotic initiation factor 2 phosphorylation.
Neoplasms
A mouse homologue of the Drosophila tumor suppressor l(2)tid gene defines a novel Ras GTPase-activating protein (RasGAP)-binding protein.
Neoplasms
A novel function of the MA-3 domains in transformation and translation suppressor Pdcd4 is essential for its binding to eukaryotic translation initiation factor 4A.
Neoplasms
A rapid and specific method to simultaneously quantify eukaryotic elongation factor 1A1 and A2 protein levels in cancer cells.
Neoplasms
A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1.
Neoplasms
A unique binding mode of the eukaryotic translation initiation factor 4E for guiding the design of novel peptide inhibitors.
Neoplasms
A WXW motif is required for the anticancer activity of the TAT-RasGAP317-326 peptide.
Neoplasms
Aberrant DNA methylation of alternative promoter of DLC1 isoform 1 in meningiomas.
Neoplasms
Aberrant methylation and deacetylation of deleted in liver cancer-1 gene in prostate cancer: potential clinical applications.
Neoplasms
Absence of Neurofibromin Induces an Oncogenic Metabolic Switch via Mitochondrial ERK-Mediated Phosphorylation of the Chaperone TRAP1.
Neoplasms
Absence of somatic mutation of a tumor suppressor gene eukaryotic translation elongation factor 1, epsilon-1 (EEF1E1), in common human cancers.
Neoplasms
Activation of the Akt/mammalian target of rapamycin pathway in myxofibrosarcomas.
Neoplasms
ADAP1 promotes invasive squamous cell carcinoma progression and predicts patient survival.
Neoplasms
Adaptation of vectors and drug-inducible systems for controlled expression of transgenes in the tumor microenvironment.
Neoplasms
Alterations in Eukaryotic Elongation Factor complex proteins (EEF1s) in cancer and their implications in epigenetic regulation.
Neoplasms
An aptamer-siRNA chimera silences the eukaryotic elongation factor 2 gene and induces apoptosis in cancers expressing ?v?3 integrin.
Neoplasms
An oncogene-tumor suppressor cascade drives metastatic prostate cancer by coordinately activating Ras and nuclear factor-kappaB.
Neoplasms
An oncogenic role for the phosphorylated h-subunit of human translation initiation factor eIF3.
Neoplasms
Analysis of integrin alpha7 mutations in prostate cancer, liver cancer, glioblastoma multiforme, and leiomyosarcoma.
Neoplasms
Analysis of nickel-binding peptides in a human hepidermoid cancer cell line by Ni-NTA affinity chromatography and mass spectrometry.
Neoplasms
Analysis of telomerase activity and RNA expression in a patient with acute promyelocytic leukemia treated with all-trans retinoic acid.
Neoplasms
Anthocyanins are novel AMPK?1 stimulators that suppress tumor growth by inhibiting mTOR phosphorylation.
Neoplasms
Antisense RNA to eIF4E suppresses oncogenic properties of a head and neck squamous cell carcinoma cell line.
Neoplasms
Antiviral Drug Ribavirin Targets Thyroid Cancer Cells by Inhibiting the eIF4E-?-Catenin Axis.
Neoplasms
Apoptotic effects of a high performance liquid chromatography (HPLC) fraction of Antrodia camphorata mycelia are mediated by down-regulation of the expressions of four tumor-related genes in human non-small cell lung carcinoma A549 cell.
Neoplasms
Aptameric GT oligomers need to be complexed to ethoxylated polyethylenimine as pre-paired duplexes to efficiently exert their cytotoxic activity in human lymphoblastic cancer cells.
Neoplasms
Arf GTPase-activating Protein AGAP2 Regulates Focal Adhesion Kinase Activity and Focal Adhesion Remodeling.
Neoplasms
ARHGAP24 inhibits cell cycle progression, induces apoptosis and suppresses invasion in renal cell carcinoma.
Neoplasms
ARHGAP6 Promotes Apoptosis and Inhibits Glycolysis in Lung Adenocarcinoma Through STAT3 Signaling Pathway.
Neoplasms
ASAP3 is a downstream target of HIF-1? and is critical for progression of lung adenocarcinoma.
Neoplasms
Autophagy-dependent cancer cells circumvent loss of the upstream regulator RB1CC1/FIP200 and loss of LC3 conjugation by similar mechanisms.
Neoplasms
Bariatric surgery can acutely modulate ER-stress and inflammation on subcutaneous adipose tissue in non-diabetic patients with obesity.
Neoplasms
Binding of eEF1A2 to the RNA-dependent protein kinase PKR modulates its activity and promotes tumour cell survival.
Neoplasms
Biochemical and Structural Insights into the eukaryotic translation initiation factor eIF4E.
Neoplasms
Blocking eIF5A modification in cervical cancer cells alters the expression of cancer-related genes and suppresses cell proliferation.
Neoplasms
Cancer-specific targeting of an adenovirus-delivered herpes simplex virus thymidine kinase suicide gene using translational control.
Neoplasms
Caspase-mediated cleavage of eukaryotic translation initiation factor subunit 2alpha.
Neoplasms
CCL18-dependent translocation of AMAP1 is critical for epithelial to mesenchymal transition in breast cancer.
Neoplasms
Cdkn2a (Arf) loss drives NF1-associated atypical neurofibroma and malignant transformation.
Neoplasms
Cell cycle-related variation in subcellular localization of eIF3e/INT6 in human fibroblasts.
Neoplasms
Cellular delivery of dinucleotides by conjugation with small molecules: targeting translation initiation for anticancer applications.
Neoplasms
Cerebrospinal fluid proteomic analysis reveals dysregulation of methionine aminopeptidase-2 expression in human and mouse neurofibromatosis 1-associated glioma.
Neoplasms
CGP57380 enhances efficacy of RAD001 in non-small cell lung cancer through abrogating mTOR inhibition-induced phosphorylation of eIF4E and activating mitochondrial apoptotic pathway.
Neoplasms
Changing for the Better: Discovery of the Highly Potent and Selective CDK9 Inhibitor VIP152 Suitable for Once Weekly Intravenous Dosing for the Treatment of Cancer.
Neoplasms
Characterization of Hydration Properties in Structural Ensembles of Biomolecules.
Neoplasms
Chemoproteomic Discovery of a Ritanserin-Targeted Kinase Network Mediating Apoptotic Cell Death of Lung Tumor Cells.
Neoplasms
Circulatory miR-98-5p levels are deregulated during diabetes and it inhibits proliferation and promotes apoptosis by targeting PPP1R15B in keratinocytes.
Neoplasms
Cisplatin-resistant cancer cells are sensitive to Aurora kinase A inhibition by alisertib.
Neoplasms
Clinical significance of eukaryotic translation initiation factor 5A2 in papillary thyroid cancer.
Neoplasms
Clinical value of eukaryotic elongation factor 2 (eEF2) in non-small cell lung cancer patients.
Neoplasms
Combined analysis of eIF4E and 4E-binding protein expression predicts breast cancer survival and estimates eIF4E activity.
Neoplasms
Combined Inhibition of SHP2 and MEK Is Effective in Models of NF1-Deficient Malignant Peripheral Nerve Sheath Tumors.
Neoplasms
Comparative proteomic analysis of anti-benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide-transformed and normal human bronchial epithelial G0/G1 cells.
Neoplasms
Comparison of the gene expression profiles of resistant and non-resistant Japanese black pine inoculated with pine wood nematode using a modified LongSAGE technique
Neoplasms
Computer-assisted image analysis can aid the prognostication of advanced-stage neuroblastomas.
Neoplasms
Concurrent EAF2 and ELL2 loss phenocopies individual EAF2 or ELL2 loss in prostate cancer cells and murine prostate.
Neoplasms
Conditional Deletion of Eaf1 Induces Murine Prostatic Intraepithelial Neoplasia in Mice.
Neoplasms
Conformational changes induced in the eukaryotic translation initiation factor eIF4E by a clinically relevant inhibitor, ribavirin triphosphate.
Neoplasms
Contradictory mRNA and protein misexpression of EEF1A1 in ductal breast carcinoma due to cell cycle regulation and cellular stress.
Neoplasms
Control of the eIF4E activity: structural insights and pharmacological implications.
Neoplasms
Cordycepin as a sensitizer to tumour necrosis factor (TNF)-?-induced apoptosis through eukaryotic translation initiation factor 2? (eIF2?)- and mammalian target of rapamycin complex 1 (mTORC1)-mediated inhibition of nuclear factor (NF)-?B.
Neoplasms
Correlation of pterygium severity with IQ-domain GTPase-activating protein 1 (IQGAP1) and mast cells.
Neoplasms
CRL4A-FBXW5-mediated degradation of DLC1 Rho GTPase-activating protein tumor suppressor promotes non-small cell lung cancer cell growth.
Neoplasms
Cyclin-dependent kinase 4 inhibits the translational repressor 4E-BP1 to promote cap-dependent translation during mitosis-G1 transition.
Neoplasms
Cysteine Proteases from V. cundinamarcensis (C. candamarcensis) Inhibit Melanoma Metastasis and Modulate Expression of Proteins Related to Proliferation, Migration and Differentiation.
Neoplasms
Dab2ip regulates neuronal migration and neurite outgrowth in the developing neocortex.
Neoplasms
Dab2IP Regulates Neuronal Positioning, Rap1 Activity and Integrin Signaling in the Developing Cortex.
Neoplasms
Deleted in liver cancer (DLC) 2 encodes a RhoGAP protein with growth suppressor function and is underexpressed in hepatocellular carcinoma.
Neoplasms
Deleted in Liver Cancer 1 (DLC1) Utilizes a Novel Binding Site for Tensin2 PTB Domain Interaction and Is Required for Tumor-Suppressive Function.
Neoplasms
Deleted in liver cancer 2 (DLC2) was dispensable for development and its deficiency did not aggravate hepatocarcinogenesis.
Neoplasms
Deleted in liver cancer 2 suppresses cell growth via the regulation of the Raf-1-ERK1/2-p70S6K signalling pathway.
Neoplasms
Deleted in liver cancer 3 (DLC-3), a novel Rho GTPase-activating protein, is downregulated in cancer and inhibits tumor cell growth.
Neoplasms
Deregulation of Stat5 expression and activation causes mammary tumors in transgenic mice.
Neoplasms
Design, synthesis and biological evaluation of pyridone-aminal derivatives as MNK1/2 inhibitors.
Neoplasms
Detection of eukaryotic translation initiation factor 4E and its clinical significance in hepatocellular carcinoma.
Neoplasms
Development of a reactive stroma associated with prostatic intraepithelial neoplasia in EAF2 deficient mice.
Neoplasms
Development of Biochemical Assays for the Identification of eIF4E-Specific Inhibitors.
Neoplasms
Differences in GTPase-activating protein activity between liver tumors and normal liver tissue in mice.
Neoplasms
Differential expression of TCEAL1 in esophageal cancers by custom cDNA microarray analysis.
Neoplasms
Differential phosphorylation of soluble versus ribosome-bound eukaryotic initiation factor 2 in the Ehrlich ascites tumor cell.
Neoplasms
Differential screening of a human pancreatic adenocarcinoma lambda gt11 expression library has identified increased transcription of elongation factor EF-1 alpha in tumour cells.
Neoplasms
Differential Transcriptomic Analysis of Spontaneous Lung Tumors in B6C3F1 Mice: Comparison to Human Non-Small Cell Lung Cancer.
Neoplasms
Diphtheria toxin- and Pseudomonas A toxin-mediated apoptosis. ADP ribosylation of elongation factor-2 is required for DNA fragmentation and cell lysis and synergy with tumor necrosis factor-alpha.
Neoplasms
Discovery of N-phenyl-4-(1H-pyrrol-3-yl)pyrimidin-2-amine derivatives as potent Mnk2 inhibitors: design, synthesis, SAR analysis, and evaluation of in vitro anti-leukaemic activity.
Neoplasms
Distinct regulation of alternative polyadenylation and gene expression by nuclear poly(A) polymerases.
Neoplasms
DLC-1, a Rho GTPase-activating protein with tumor suppressor function, is essential for embryonic development.
Neoplasms
DLC1 Activation Requires Lipid Interaction through a Polybasic Region Preceding the RhoGAP Domain.
Neoplasms
Dlc1 interaction with non-muscle myosin heavy chain II-A (Myh9) and Rac1 activation.
Neoplasms
DLC1 interaction with S100A10 mediates inhibition of in vitro cell invasion and tumorigenicity of lung cancer cells through a RhoGAP-independent mechanism.
Neoplasms
DNA Methylation Profiling in Pheochromocytoma and Paraganglioma Reveals Diagnostic and Prognostic Markers.
Neoplasms
Double-stranded RNA-dependent protein kinase phosphorylation of the alpha-subunit of eukaryotic translation initiation factor 2 mediates apoptosis.
Neoplasms
Down-regulation of eIF4GII by miR-520c-3p represses diffuse large B cell lymphoma development.
Neoplasms
Down-regulation of human DAB2IP gene expression mediated by polycomb Ezh2 complex and histone deacetylase in prostate cancer.
Neoplasms
Down-regulation of RASA1 Is Associated with Poor Prognosis in Human Hepatocellular Carcinoma.
Neoplasms
Downregulated expression of ARHGAP10 correlates with advanced stage and high Ki-67 index in breast cancer.
Neoplasms
Downregulation of eIF4G by microRNA-503 enhances drug sensitivity of MCF-7/ADR cells through suppressing the expression of ABC transport proteins.
Neoplasms
Downregulation of eukaryotic translation initiation factor 3b inhibited proliferation and metastasis of gastric cancer.
Neoplasms
Downregulation of IQGAP1 inhibits epithelial-mesenchymal transition via the HIF1?/VEGF-A signaling pathway in gastric cancer.
Neoplasms
Downregulation of Ral GTPase-activating protein promotes tumor invasion and metastasis of bladder cancer.
Neoplasms
Downregulation of TCEAL7 expression induces CCND1 expression in non-small cell lung cancer.
Neoplasms
EBP1 suppresses growth, migration, and invasion of thyroid cancer cells through upregulating RASAL expression.
Neoplasms
eEF1A2 activates Akt and stimulates Akt-dependent actin remodeling, invasion and migration.
Neoplasms
EEF1D overexpression promotes osteosarcoma cell proliferation by facilitating Akt-mTOR and Akt-bad signaling.
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Effect of activation of the Akt/mTOR signaling pathway by EEF1A2 on the biological behavior of osteosarcoma.
Neoplasms
Effects of eEF1A1 targeting by aptamer/siRNA in chronic lymphocytic leukaemia cells.
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Ehrlichia chaffeensis TRP32 interacts with host cell targets that influence intracellular survival.
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eIF-2 initiation factor activity in Yoshida ascites hepatoma AH 130 cells and in 4-dimethylaminoazobenzene-induced liver tumor tissue during growth.
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EIF2A-dependent translational arrest protects leukemia cells from the energetic stress induced by NAMPT inhibition.
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EIF3C-enhanced exosome secretion promotes angiogenesis and tumorigenesis of human hepatocellular carcinoma.
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EIF3H promotes aggressiveness of esophageal squamous cell carcinoma by modulating Snail stability.
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EIF3m promotes the malignant phenotype of lung adenocarcinoma by the up-regulation of oncogene CAPRIN1.
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eIF4E activation is commonly elevated in advanced human prostate cancers and significantly related to reduced patient survival.
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EIF4E over-expresses and enhances cell proliferation and cell cycle progression in nasopharyngeal carcinoma.
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eIF4E-targeted suicide gene therapy in a minimal residual mouse model for metastatic soft-tissue head and neck squamous cell carcinoma improves disease-free survival.
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EIF5A regulates proliferation and chemoresistance in pancreatic cancer through the sHH signalling pathway.
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eIF5A-PEAK1 Signaling Regulates YAP1/TAZ Protein Expression and Pancreatic Cancer Cell Growth.
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EIF5A2 is highly expressed in anaplastic thyroid carcinoma and is associated with tumor growth by modulating TGF-? signals.
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EIF5A2 predicts outcome in localised invasive bladder cancer and promotes bladder cancer cell aggressiveness in vitro and in vivo.
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eIF5B regulates the expression of PD-L1 in prostate cancer cells by interacting with Wig1.
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Electrophysiology of glioma: a Rho GTPase-activating protein reduces tumor growth and spares neuron structure and function.
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Elevated expression of eIF4E and FGF-2 isoforms during vascularization of breast carcinomas.
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Elevation of EIF4G1 promotes non-small cell lung cancer progression by activating mTOR signalling.
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ELL2 Is Required for the Growth and Survival of AR-Negative Prostate Cancer Cells.
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Ell3 functions as a critical decision maker at the crossroad between stem cell senescence and apoptosis.
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Elongation factor 1 from ascites tumor cells: interaction with ribosomes and elongation factor 2.
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Elongation factor eEF2 kinase and autophagy jointly promote survival of cancer cells.
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Enhance tumor radiosensitivity by intracellular delivery of eukaryotic translation initiation factor 4E binding proteins.
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Epigenetic silencing of a Ca(2+)-regulated Ras GTPase-activating protein RASAL defines a new mechanism of Ras activation in human cancers.
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Essential role for eIF4GI overexpression in the pathogenesis of inflammatory breast cancer.
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Established and Emerging Regulatory Roles of Eukaryotic Translation Initiation Factor 5B (eIF5B).
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Estrogen-Induced Apoptosis in Breast Cancers Is Phenocopied by Blocking Dephosphorylation of Eukaryotic Initiation Factor 2 Alpha (eIF2?) Protein.
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Eukaryotic elongation factor 1A2 cooperates with phosphatidylinositol-4 kinase III beta to stimulate production of filopodia through increased phosphatidylinositol-4,5 bisphosphate generation.
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Eukaryotic Elongation Factor 2 (eEF2) is a Potential Biomarker of Prostate Cancer.
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Eukaryotic elongation factor 2 kinase confers tolerance to stress conditions in cancer cells.
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Eukaryotic initiation factor 2-associated glycoprotein, p67, shows differential effects on the activity of certain kinases during serum-starved conditions.
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Eukaryotic initiation factor 3C silencing inhibits cell proliferation and promotes apoptosis in human glioma.
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Eukaryotic initiation factor 5B (eIF5B) provides a critical cell survival switch to glioblastoma cells via regulation of apoptosis.
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Eukaryotic initiation factor 5B (eIF5B) regulates temozolomide-mediated apoptosis in brain tumor stem cells (BTSCs).
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Eukaryotic Initiation Factors (eIF) 2{alpha} and 4E Expression, Localization, and Phosphorylation in Brain Tumors.
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Eukaryotic translation elongation factor 1?, N-terminal propeptide of type I collagen and cancer-associated fibroblasts are prognostic markers of oral squamous cell carcinoma patients.
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Eukaryotic Translation Initiation Factor 3 Subunit B Is a Promoter in the Development and Progression of Pancreatic Cancer.
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Eukaryotic translation initiation factor 3B is overexpressed and correlates with higher FIGO stage III/IV, lymph node metastasis and unfavorable survival profiles in cervical cancer patients.
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Eukaryotic Translation Initiation Factor 4 Gamma 1 (EIF4G1): a target for cancer therapeutic intervention?
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Eukaryotic translation initiation factor 4E (eIF-4E) expressions are associated with poor prognosis in colorectal adenocarcinoma.
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Eukaryotic translation initiation factor 4E (eIF4E) expression is associated with breast cancer tumor phenotype and predicts survival after anthracycline chemotherapy treatment.
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Eukaryotic translation initiation factor 4E induced progression of primary human mammary epithelial cells along the cancer pathway is associated with targeted translational deregulation of oncogenic drivers and inhibitors.
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Eukaryotic Translation Initiation Factor 4E Is a Feed-Forward Translational Coactivator of Transforming Growth Factor ? Early Protransforming Events in Breast Epithelial Cells.
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Eukaryotic translation initiation factor 5A induces apoptosis in colon cancer cells and associates with the nucleus in response to tumour necrosis factor alpha signalling.
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Eukaryotic translation initiation factor 5A2 (eIF5A2) regulates chemoresistance in colorectal cancer through epithelial mesenchymal transition.
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Eukaryotic translation initiation factor 5A2 is highly expressed in prostate cancer and predicts poor prognosis.
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Eukaryotic translation initiation factor 5A2 regulates the migration and invasion of hepatocellular carcinoma cells via pathways involving reactive oxygen species.
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Eukaryotic translation initiation factor EIF3H potentiates gastric carcinoma cell proliferation.
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Evolutionarily Conserved Binding of Translationally-Controlled Tumor Protein to Eukaryotic Elongation Factor 1B.
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Exercise Preconditioning Protects against Acute Cardiac Injury Induced by Lipopolysaccharide Through General Control Nonderepressible 2 Kinase.
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Exploring tryptamine conjugates as pronucleotides of phosphate-modified 7-methylguanine nucleotides targeting cap-dependent translation.
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Exposure of the cryptic de-adhesive site FNIII14 in fibronectin molecule and its binding to membrane-type eEF1A induce migration and invasion of cancer cells via ?1-integrin inactivation.
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Expression analysis of global gene response to chronic heat exposure in broiler chickens (Gallus gallus) reveals new reactive genes.
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Expression of an elongation factor 1 gamma-related sequence in adenocarcinomas of the colon.
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Expression of Elongation Factor (EF)-Tu Is Correlated with Prognosis of Gastric Adenocarcinomas.
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Expression of RACGAP1 in high grade meningiomas: a potential role in cancer progression.
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Expression of the translation initiation factor eIF4E in the polyp-cancer sequence in the colon.
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Expression of the Y-Encoded TSPY is Associated with Progression of Prostate Cancer.
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Expression of total and phospho 4EBP1 in metastatic and non-metastatic renal cell carcinoma.
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Expression of translation initiation factor eIF-2alpha is increased in benign and malignant melanocytic and colonic epithelial neoplasms.
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Expression of truncated eIF3e resulting from integration of MMTV causes a shift from Cap-dependent to Cap-independent translation.
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Expression pattern of EEF1A2 in brain tumors: Histological analysis and functional role as a promoter of EMT.
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Expression profile of eukaryotic translation factors in human cancer tissues and cell lines.
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Expression, signaling proficiency, and stimulatory function of the NKG2D lymphocyte receptor in human cancer cells.
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FilGAP, a GAP protein for Rac, regulates front-rear polarity and tumor cell migration through the ECM.
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FilGAP, a Rho/Rho-associated protein kinase-regulated GTPase-activating protein for Rac, controls tumor cell migration.
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First MNKs degrading agents block phosphorylation of eIF4E, induce apoptosis, inhibit cell growth, migration and invasion in triple negative and Her2-overexpressing breast cancer cell lines.
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Fission yeast homolog of murine Int-6 protein, encoded by mouse mammary tumor virus integration site, is associated with the conserved core subunits of eukaryotic translation initiation factor 3.
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FLI1 promotes protein translation via the transcriptional regulation of MKNK1 expression.
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Fucoidan induces cancer cell apoptosis by modulating the endoplasmic reticulum stress cascades.
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Function of human cytomegalovirus UL97 kinase in viral infection and its inhibition by maribavir.
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Functional identity of the monomeric and multiple forms of elongation-factor 1 from Krebs-II mouse ascites-tumor cells.
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Functional role of eukaryotic translation initiation factor 4 gamma 1 (EIF4G1) in NSCLC.
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Further evidence that elongation factor 1 remains bound to ribosomes during peptide chain elongation.
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Gating by tryptophan 73 exposes a cryptic pocket at the protein-binding interface of the oncogenic eIF4E protein.
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Gene expression profile analysis in response to ?1,2-fucosyl transferase (FUT1) gene transfection in epithelial ovarian carcinoma cells.
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Genetic and Pharmacologic Inhibition of eIF4E Reduces Breast Cancer Cell Migration, Invasion, and Metastasis.
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Germline polymorphisms in SIPA1 are associated with metastasis and other indicators of poor prognosis in breast cancer.
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Glucocorticoid receptor DNA binding factor 1 expression and osteosarcoma prognosis.
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Green tea polyphenol epigallocatechin-3-gallate signaling pathway through 67-kDa laminin receptor.
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GTPase-activating protein Rasal1 associates with ZAP-70 of the TCR and negatively regulates T-cell tumor immunity.
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Guanine nucleotides regulate sphingosine kinase 1 activation by eukaryotic elongation factor 1A and provide a mechanism for eEF1A-associated oncogenesis.
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HE4 and eIF3a Expression Correlates with Surgical Outcome and Overall Survival in Ovarian Cancer Patients with Secondary Cytoreduction.
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High EIF2B5 mRNA expression and its prognostic significance in liver cancer: a study based on the TCGA and GEO database.
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High eukaryotic translation elongation factor 1 alpha 1 expression promotes proliferation and predicts poor prognosis in clear cell renal cell carcinoma.
Neoplasms
High expression of disabled homolog 2-interacting protein contributes to tumor development and proliferation in cutaneous squamous cell carcinoma.
Neoplasms
High expression of eIF3d is associated with poor prognosis in patients with gastric cancer.
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High intratumoral expression of eIF4A1 promotes epithelial-to-mesenchymal transition and predicts unfavorable prognosis in gastric cancer.
Neoplasms
HPV E6 induces eIF4E transcription to promote the proliferation and migration of cervical cancer.
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hsa_circ_0101119 facilitates the progression of cervical cancer via an interaction with EIF4A3 to inhibit TCEAL6 expression.
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Hsp90 inhibitors and the reduction of anti-cancer drug resistance by non-genetic and genetic mechanisms.
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HSP90/AXL/eIF4E-regulated unfolded protein response as an acquired vulnerability in drug-resistant KRAS-mutant lung cancer.
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Human Elongation Factor 4 Regulates Cancer Bioenergetics by Acting as a Mitochondrial Translation Switch.
Neoplasms
Human prostatic carcinoma oncogene PTI-1 is expressed in human tumor cell lines and prostate carcinoma patient blood samples.
Neoplasms
Hyperactivation of protein kinase B and ERK have discrete effects on survival, proliferation, and cytokine expression in Nf1-deficient myeloid cells.
Neoplasms
Identification and characterization of an inhibitor of eukaryotic elongation factor 2 kinase against human cancer cell lines.
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Identification of a selective DDX3X inhibitor with newly developed quantitative high-throughput RNA helicase assays.
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Identification of a Specific Translational Machinery via TCTP-EF1A2 Interaction Regulating NF1-associated Tumor Growth by Affinity Purification and Data-independent Mass Spectrometry Acquisition (AP-DIA).
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Identification of altered protein expression and post-translational modifications in primary colorectal cancer by using agarose two-dimensional gel electrophoresis.
Neoplasms
Identification of di-substituted ureas that prevent growth of trypanosomes through inhibition of translation initiation.
Neoplasms
Identification of different isoforms of eEF1A in the nuclear fraction of human T-lymphoblastic cancer cell line specifically binding to aptameric cytotoxic GT oligomers.
Neoplasms
Identification of elicitor-responsive proteins in rice leaves by a proteomic approach.
Neoplasms
Identification of elongation factor g as the conserved cellular target of argyrin B.
Neoplasms
Identification of elongin C sequences required for interaction with the von Hippel-Lindau tumor suppressor protein.
Neoplasms
Identification of genes regulated by oleic acid in Jurkat cells by suppressive subtractive hybridization analysis.
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Identification of heat shock protein 90 and other proteins as tumour antigens by serological screening of an ovarian carcinoma expression library.
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Identification of known and novel genes in activated monocytes from patients with rheumatoid arthritis.
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Identification of novel cellular targets in biliary tract cancers using global gene expression technology.
Neoplasms
Identification of novel proteins associated with the development of chemoresistance in malignant melanoma using two-dimensional electrophoresis.
Neoplasms
Identification of p122RhoGAP (Deleted in Liver Cancer-1) Serine 322 as a Substrate for Protein Kinase B and Ribosomal S6 Kinase in Insulin-stimulated Cells.
Neoplasms
Identification of Potential Anticancer Protein Targets in Cytotoxicity Mediated by Tropical Medicinal Fern Extracts.
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IGL-1 solution reduces endoplasmic reticulum stress and apoptosis in rat liver transplantation.
Neoplasms
IL-24 Promotes Apoptosis through cAMP-Dependent PKA Pathways in Human Breast Cancer Cells.
Neoplasms
Impact of the secretome of activated pancreatic stellate cells on growth and differentiation of pancreatic tumour cells.
Neoplasms
Implications of the Use of Eukaryotic Translation Initiation Factor 5A (eIF5A) for Prognosis and Treatment of Hepatocellular Carcinoma.
Neoplasms
Importin 8 mediates m7G cap-sensitive nuclear import of the eukaryotic translation initiation factor eIF4E.
Neoplasms
In-depth proteome analysis of the rubber particle of Hevea brasiliensis (para rubber tree).
Neoplasms
Increased activity of the eEF-2 specific, Ca2+ and calmodulin dependent protein kinase III during the S-phase in Ehrlich ascites cells.
Neoplasms
Increased expression of phosphorylated forms of RNA-dependent protein kinase and eukaryotic initiation factor 2alpha may signal skeletal muscle atrophy in weight-losing cancer patients.
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Increased HE4 mRNA Expression Correlates with High Level Of eIF3a mRNA And Better Survival in Women with Epithelial Ovarian Cancer.
Neoplasms
Increased levels of the translation initiation factor eIF4E in differentiating epithelial lung tumor cell lines.
Neoplasms
Induction of apoptosis in human cancer cells by candidaspongiolide, a novel sponge polyketide.
Neoplasms
Influence of DPH1 and DPH5 Protein Variants on the Synthesis of Diphthamide, the Target of ADPRibosylating Toxins.
Neoplasms
Inhibition of activation of dsRNA-dependent protein kinase and tumour growth inhibition.
Neoplasms
Inhibition of cell proliferation, induction of apoptosis, reactivation of DLC1, and modulation of other gene expression by dietary flavone in breast cancer cell lines.
Neoplasms
Inhibition of eIF2alpha dephosphorylation inhibits ErbB2-induced deregulation of mammary acinar morphogenesis.
Neoplasms
Inhibition of eIF2alpha dephosphorylation maximizes bortezomib efficiency and eliminates quiescent multiple myeloma cells surviving proteasome inhibitor therapy.
Neoplasms
Inhibition of eukaryotic elongation factor-2 confers to tumor suppression by a herbal formulation Huanglian-Jiedu decoction in human hepatocellular carcinoma.
Neoplasms
Inhibition of fatty acid synthase induces endoplasmic reticulum stress in tumor cells.
Neoplasms
Inhibition of nonsense-mediated RNA decay by the tumor microenvironment promotes tumorigenesis.
Neoplasms
Inhibition of ovarian cancer growth by a tumor-targeting peptide that binds eukaryotic translation initiation factor 4E.
Neoplasms
Inhibition of PERK-dependent pro-adaptive signaling pathway as a promising approach for cancer treatment.
Neoplasms
Inhibition of proliferation, invasion, and migration of prostate cancer cells by down-regulating elongation factor-1 alpha expression.
Neoplasms
Inhibition of the SEC61 translocon by mycolactone induces a protective autophagic response controlled by EIF2S1-dependent translation that does not require ULK1 activity.
Neoplasms
Integrated analysis revealing genome-wide chromosomal copy number variation in supraglottic laryngeal squamous cell carcinoma.
Neoplasms
Interaction of G-rich GT oligonucleotides with nuclear-associated eEF1A is correlated with their antiproliferative effect in haematopoietic human cancer cell lines.
Neoplasms
Interaction of the Ras-related protein associated with diabetes rad and the putative tumor metastasis suppressor NM23 provides a novel mechanism of GTPase regulation.
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Interactions of protein kinase CK2beta subunit within the holoenzyme and with other proteins.
Neoplasms
Investigation of the eIF2alpha phosphorylation mechanism in response to proteasome inhibition in melanoma and breast cancer cells.
Neoplasms
Involvement of a novel ADP-ribosylation factor GTPase-activating protein, SMAP, in membrane trafficking: implications in cancer cell biology.
Neoplasms
Involvement of endoplasmic reticulum stress in capsaicin-induced apoptosis of human pancreatic cancer cells.
Neoplasms
Involvement of Ras GTPase-activating protein SH3 domain-binding protein 1 in the epithelial-to-mesenchymal transition-induced metastasis of breast cancer cells via the Smad signaling pathway.
Neoplasms
Involvement of small ArfGAP1 (SMAP1), a novel Arf6-specific GTPase-activating protein, in microsatellite instability oncogenesis.
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IQ-domain GTPase-activating protein 1 promotes the malignant phenotype of invasive ductal breast carcinoma via canonical Wnt pathway.
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IQGAP1 and IQGAP3 Serve Individually Essential Roles in Normal Epidermal Homeostasis and Tumor Progression.
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IQGAP1 Is Involved in Enhanced Aggressive Behavior of Epithelial Ovarian Cancer Stem Cell-Like Cells During Differentiation.
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IQGAP1 modulates the proliferation and invasion of thyroid cancer cells in response to estrogen.
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iTRAQ Identification of Candidate Serum Biomarkers Associated with Metastatic Progression of Human Prostate Cancer.
Neoplasms
Knockdown of eIF3d inhibits cell proliferation through G2/M phase arrest in non-small cell lung cancer.
Neoplasms
Knockdown of eIF4E suppresses cell growth and migration, enhances chemosensitivity and correlates with increase in Bax/Bcl-2 ratio in triple-negative breast cancer cells.
Neoplasms
Knockdown of EIF5A2 inhibits the malignant potential of non-small cell lung cancer cells.
Neoplasms
Knockdown of eukaryotic translation initiation factor 3 subunit D (eIF3D) inhibits proliferation of acute myeloid leukemia cells.
Neoplasms
Knockdown of RLIP76 expression by RNA interference inhibits invasion, induces cell cycle arrest, and increases chemosensitivity to the anticancer drug temozolomide in glioma cells.
Neoplasms
Knockdown of TFIIS by RNA silencing inhibits cancer cell proliferation and induces apoptosis.
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KRAS-Driven Cancers Are Dependent on METTL13-Mediated eEF1A Methylation.
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Learning deficits, but normal development and tumor predisposition, in mice lacking exon 23a of Nf1.
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Lentiviral vector mediated-ASAP1 expression promotes epithelial to mesenchymal transition in ovarian cancer cells.
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Lentivirus-mediated knockdown of eukaryotic translation initiation factor 3 subunit D inhibits proliferation of HCT116 colon cancer cells.
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Levels of Hepatic Activating Transcription Factor 6 and Caspase-3 Are Downregulated in Mice after Excessive Training.
Neoplasms
Levels, phosphorylation status and cellular localization of translational factor eIF2 in gastrointestinal carcinomas.
Neoplasms
Loss of MIEF1/MiD51 confers susceptibility to BAX-mediated cell death and PINK1-PRKN-dependent mitophagy.
Neoplasms
Low expression of DAB2IP contributes to malignant development and poor prognosis in hepatocellular carcinoma.
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Low expression of DAB2IP predicts an unfavorable prognosis in human bladder carcinoma.
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Low generation PAMAM dendrimer and CpG free plasmids allow targeted and extended transgene expression in tumors after systemic delivery.
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Malignant transformation by the eukaryotic translation initiation factor 3 subunit p48 (eIF3e).
Neoplasms
Mammalian mediator subunit mMED8 is an Elongin BC-interacting protein that can assemble with Cul2 and Rbx1 to reconstitute a ubiquitin ligase.
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MAP4K3/GLK promotes lung cancer metastasis by phosphorylating and activating IQGAP1.
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Mass spectrometric identification of ancient proteins as potential molecular biomarkers for a 2000-year-old osteogenic sarcoma.
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MD11-mediated delivery of recombinant eIF3f induces melanoma and colorectal carcinoma cell death.
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Mechanism-based screen for G1/S checkpoint activators identifies a selective activator of EIF2AK3/PERK signalling.
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METTL13 Methylation of eEF1A Increases Translational Output to Promote Tumorigenesis.
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METTL21B is a prognostic biomarker and potential therapeutic target in low-grade gliomas.
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MicroRNA-182 Promotes Tumor Cell Growth by Targeting Transcription Elongation Factor A-like 7 in Endometrial Carcinoma.
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MicroRNA?875?5p inhibits tumor growth and metastasis of hepatocellular carcinoma by targeting eukaryotic translation initiation factor 3 subunit a.
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Minimum requirements for the function of eukaryotic translation initiation factor 2.
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MNK Inhibition Disrupts Mesenchymal Glioma Stem Cells and Prolongs Survival in a Mouse Model of Glioblastoma.
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Modulation of eIF5A expression using SNS01 nanoparticles inhibits NF-?B activity and tumor growth in murine models of multiple myeloma.
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Modulation of tumor eIF4E by antisense inhibition: A phase I/II translational clinical trial of ISIS 183750-an antisense oligonucleotide against eIF4E-in combination with irinotecan in solid tumors and irinotecan-refractory colorectal cancer.
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Molecular interaction between human tumor marker protein p150, the largest subunit of eIF3, and intermediate filament protein K7.
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Molecular mechanisms and anti-cancer aspects of the medicinal phytochemicals rocaglamides (=flavaglines).
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Molecular targeting of the oncogene eIF4E in AML: a proof-of-principle clinical trial with ribavirin.
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Muf1, a novel Elongin BC-interacting leucine-rich repeat protein that can assemble with Cul5 and Rbx1 to reconstitute a ubiquitin ligase.
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Multiple Functions and Mechanisms Underlying the Role of METTL3 in Human Cancers.
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N1-guanyl-1,7-diaminoheptane enhances the chemosensitivity of acute lymphoblastic leukemia cells to vincristine through inhibition of eif5a-2 activation.
Neoplasms
NELF interacts with CBC and participates in 3' end processing of replication-dependent histone mRNAs.
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NELFE promoted pancreatic cancer metastasis and the epithelial?to?mesenchymal transition by decreasing the stabilization of NDRG2 mRNA.
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Neurofibromatosis type I tumor suppressor neurofibromin regulates neuronal differentiation via its GTPase-activating protein function toward Ras.
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Neurofibromin-deficient Schwann cells secrete a potent migratory stimulus for Nf1+/- mast cells.
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New HIF2? inhibitors: potential implications as therapeutics for advanced pheochromocytomas and paragangliomas.
Neoplasms
New insights into the interplay between autophagy, gut microbiota and inflammatory responses in IBD.
Neoplasms
New insights on the interaction between the isoforms 1 and 2 of human translation elongation factor 1A.
Neoplasms
Next-generation sequencing identified somatic alterations that may underlie the etiology of Chinese papillary thyroid carcinoma.
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NF1 and Neurofibromin: Emerging Players in the Genetic Landscape of Desmoplastic Melanoma.
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Novel arylsulfoanilide-oxindole hybrid as an anticancer agent that inhibits translation initiation.
Neoplasms
Nuclear DLC1 exerts oncogenic function through association with FOXK1 for cooperative activation of MMP9 expression in melanoma.
Neoplasms
OLA1 regulates protein synthesis and integrated stress response by inhibiting eIF2 ternary complex formation.
Neoplasms
Over-activation of EFTUD2 correlates with tumor propagation and poor survival outcomes in hepatocellular carcinoma.
Neoplasms
Over-expression of eukaryotic translation initiation factor 4 gamma 1 correlates with tumor progression and poor prognosis in nasopharyngeal carcinoma.
Neoplasms
Over-expression of IQGAP1 indicates poor prognosis in head and neck squamous cell carcinoma.
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Overexpression of eEF1A1 regulates G1-phase progression to promote HCC proliferation through the STAT1-cyclin D1 pathway.
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Overexpression of eukaryotic translation initiation factor 5A2 (EIF5A2) correlates with cell aggressiveness and poor survival in gastric cancer.
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Overexpression of p-Akt, p-mTOR and p-eIF4E proteins associates with metastasis and unfavorable prognosis in non-small cell lung cancer.
Neoplasms
Overexpression of RLIP76 Required for Proliferation in Meningioma Is Associated with Recurrence.
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Overexpression of the MEN/ELL protein, an RNA polymerase II elongation factor, results in transformation of Rat1 cells with dependence on the lysine-rich region.
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p120Ras-GAP binds the DLC1 Rho-GAP tumor suppressor protein and inhibits its RhoA GTPase and growth-suppressing activities.
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Parotid gland tumors correlation between routine cytology and cytomorphometry by digital image analysis using conventional and newly introduced cytomorphometric parameters.
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Pathogenicity and virulence of Japanese encephalitis virus: Neuroinflammation and neuronal cell damage.
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Pharmacological suppression of B7-H4 glycosylation restores antitumor immunity in immune-cold breast cancers.
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Phosphoproteomic analysis of signaling pathways in head and neck squamous cell carcinoma patient samples.
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Phosphorylated eIF2? predicts disease-free survival in triple-negative breast cancer patients.
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Phosphorylated eukaryotic translation initiation factor 4 (eIF4E) is elevated in human cancer tissues.
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Phosphorylated p70S6K expression is an independent prognosticator for patients with esophageal squamous cell carcinoma.
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Phosphorylation of eIF2alpha is required for mRNA translation inhibition and survival during moderate hypoxia.
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Phosphorylation of eIF4E Confers Resistance to Cellular Stress and DNA-Damaging Agents through an Interaction with 4E-T: A Rationale for Novel Therapeutic Approaches.
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Phosphorylation of eIF4E promotes EMT and metastasis via translational control of SNAIL and MMP-3.
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Phosphorylation of eIF4E serine 209 is associated with tumour progression and reduced survival in malignant melanoma.
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Phosphorylation of the eukaryotic translation initiation factor eIF4E contributes to its transformation and mRNA transport activities.
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Poorly differentiated carcinoma of the thyroid gland: Current status and future prospects.
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PRC2 loss amplifies Ras-driven transcription and confers sensitivity to BRD4-based therapies.
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Prognostic score for patients with localized renal cell carcinoma treated by nephrectomy.
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Prognostic significance of the expression of nuclear eukaryotic translation initiation factor 5A2 in human melanoma.
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Protein expression of eIF4E and integrin ?v?6 in colon cancer can predict clinical significance, reveal their correlation and imply possible mechanism of interaction.
Neoplasms
Protein kinase RNA-like ER kinase/eukaryotic translation initiation factor 2? pathway attenuates tumor necrosis factor alpha-induced apoptosis in nucleus pulposus cells by activating autophagy.
Neoplasms
Protein phosphatase 2A negatively regulates eukaryotic initiation factor 4E phosphorylation and eIF4F assembly through direct dephosphorylation of Mnk and eIF4E.
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Protein synthesis in tumor host. II. Increased activity of peptide elongation factor 1 in experimental rat tumors and in host liver.
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Protein synthesis inhibition by flavonoids: roles of eukaryotic initiation factor 2alpha kinases.
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Proteins of the Nucleolus of Dictyostelium discoideum: Nucleolar Compartmentalization, Targeting Sequences, Protein Translocations and Binding Partners.
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Proteomic Analysis of Cervical Cancer Cells Treated with Adenovirus-Mediated MDA-7.
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Proteomic analysis of tumor tissue in CT-26 implanted BALB/C mouse after treatment with ascorbic acid.
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Proteomic and phosphoproteomic alterations in benign, premalignant and tumor human breast epithelial cells and xenograft lesions: biomarkers of progression.
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Proteomic profiling of differential display analysis for human oral squamous cell carcinoma: 14-3-3 ? Protein is upregulated in human oral squamous cell carcinoma and dependent on the differentiation level.
Neoplasms
Quantitative proteomic analysis of temporal lysosomal proteome and the impact of the KFERQ-like motif and LAMP2A in lysosomal targeting.
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R-Ras subfamily proteins elicit distinct physiologic effects and phosphoproteome alterations in neurofibromin-null MPNST cells.
Neoplasms
Rac1 mediates the osteoclast gains-in-function induced by haploinsufficiency of Nf1.
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Rac1-mediated sustained ?4 integrin level develops reattachment ability of breast cancer cells after anchorage loss.
Neoplasms
RacGAP1 ameliorates acute kidney injury by promoting proliferation and suppressing apoptosis of renal tubular cells.
Neoplasms
Raf kinases mediate the phosphorylation of eukaryotic translation elongation factor 1A and regulate its stability in eukaryotic cells.
Neoplasms
Ral GTPase-activating protein regulates the malignancy of pancreatic ductal adenocarcinoma.
Neoplasms
Rapid Discovery of Functional Small Molecule Ligands against Proteomic Targets through Library-Against-Library Screening.
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Rapid induction of apoptosis mediated by peptides that bind initiation factor eIF4E.
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RAS nucleotide cycling underlies the SHP2 phosphatase dependence of mutant BRAF-, NF1- and RAS-driven cancers.
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RAS/MAPK pathway hyperactivation determines poor prognosis in undifferentiated pleomorphic sarcomas.
Neoplasms
RASAL2, a RAS GTPase-activating protein, inhibits stemness and epithelial-mesenchymal transition via MAPK/SOX2 pathway in bladder cancer.
Neoplasms
Re: Downregulation of Ral GTPase-Activating Protein Promotes Tumor Invasion and Metastasis of Bladder Cancer.
Neoplasms
Recent developments in targeting the mammalian target of rapamycin (mTOR) kinase pathway.
Neoplasms
Receptor tyrosine kinase activation of RhoA is mediated by AKT phosphorylation of DLC1.
Neoplasms
Reduced expression of neurofibromin in the soft tissue tumours obtained from patients with neurofibromatosis type I.
Neoplasms
Reduction of translation initiation factor 4E decreases the malignancy of ras-transformed cloned rat embryo fibroblasts.
Neoplasms
Regulation of ELL2 stability and polyubiquitination by EAF2 in prostate cancer cells.
Neoplasms
Regulation of elongation factor-1alpha expression by growth factors and anti-receptor blocking antibodies.
Neoplasms
Regulation of tumor suppressor EAF2 polyubiquitination by ELL1 and SIAH2 in prostate cancer cells.
Neoplasms
Resveratrol suppresses growth of human ovarian cancer cells in culture and in a murine xenograft model: eukaryotic elongation factor 1A2 as a potential target.
Neoplasms
Rho GTPase-activating protein 35 rs1052667 polymorphism and osteosarcoma risk and prognosis.
Neoplasms
Ribavirin augments doxorubicin's efficacy in human hepatocellular carcinoma through inhibiting doxorubicin-induced eIF4E activation.
Neoplasms
Ribavirin Inhibits the Activity of mTOR/eIF4E, ERK/Mnk1/eIF4E Signaling Pathway and Synergizes with Tyrosine Kinase Inhibitor Imatinib to Impair Bcr-Abl Mediated Proliferation and Apoptosis in Ph+ Leukemia.
Neoplasms
Ribavirin suppresses eIF4E-mediated oncogenic transformation by physical mimicry of the 7-methyl guanosine mRNA cap.
Neoplasms
Ribavirin treatment effects on breast cancers overexpressing eIF4E, a biomarker with prognostic specificity for luminal B-type breast cancer.
Neoplasms
RNA binding motif protein 10 suppresses lung cancer progression by controlling alternative splicing of eukaryotic translation initiation factor 4H.
Neoplasms
Role for the double-stranded RNA activated protein kinase PKR in E2F-1-induced apoptosis.
Neoplasms
Role of EIF4G1 network in non-small cell lung cancers (NSCLC) cell survival and disease progression.
Neoplasms
Role of Endoplasmic Reticulum Stress in Proinflammatory Cytokine-Mediated Inhibition of Trophoblast Invasion in Placenta-Related Complications of Pregnancy.
Neoplasms
Role of the tuberous sclerosis gene-2 product in cell cycle control. Loss of the tuberous sclerosis gene-2 induces quiescent cells to enter S phase.
Neoplasms
Roles of the translation initiation factor eIF2? serine 51 phosphorylation in cancer formation and treatment.
Neoplasms
S6K1- and betaTRCP-mediated degradation of PDCD4 promotes protein translation and cell growth.
Neoplasms
Salubrinal Enhances Doxorubicin Sensitivity in Human Cholangiocarcinoma Cells Through Promoting DNA Damage.
Neoplasms
SBI-0640756 Attenuates the Growth of Clinically Unresponsive Melanomas by Disrupting the eIF4F Translation Initiation Complex.
Neoplasms
Scaffolding Protein IQGAP1 Is Dispensable, but Its Overexpression Promotes Hepatocellular Carcinoma via YAP1 Signaling.
Neoplasms
Screening and identification of interacting proteins with hepatitis B virus core protein in leukocytes and cloning of new gene C1.
Neoplasms
Secretome of human bone marrow mesenchymal stem cells: an emerging player in lung cancer progression and mechanisms of translation initiation.
Neoplasms
Selective inhibition of growth of tuberous sclerosis complex 2 null cells by atorvastatin is associated with impaired Rheb and Rho GTPase function and reduced mTOR/S6 kinase activity.
Neoplasms
Selective killing of cancer cells based on translational control of a suicide gene.
Neoplasms
Sema4d is required for the development of the hindbrain boundary and skeletal muscle in zebrafish.
Neoplasms
Sensitivity of doxorubicin-resistant cells to sorafenib: possible role for inhibition of eukaryotic initiation factor-2alpha phosphorylation.
Neoplasms
Sequential Interferon ?-Cisplatin Treatment Enhances the Surface Exposure of Calreticulin in Cancer Cells via an Interferon Regulatory Factor 1-Dependent Manner.
Neoplasms
SEREX identification of new tumour-associated antigens in cutaneous T-cell lymphoma.
Neoplasms
Serum anti-EIF3A autoantibody as a potential diagnostic marker for hepatocellular carcinoma.
Neoplasms
Significantly increased cortisol secretion in normal adrenocortical cells transfected with K-ras mutants derived from human functional adrenocortical tumors.
Neoplasms
Silencing of DLC1 upregulates PAI-1 expression and reduces migration in normal prostate cells.
Neoplasms
Single cell Ras-GTP analysis reveals altered Ras activity in a subpopulation of neurofibroma Schwann cells but not fibroblasts.
Neoplasms
Skeletal muscle atrophy, a link between depression of protein synthesis and increase in degradation.
Neoplasms
SMURF1-mediated ubiquitination of ARHGAP26 promotes ovarian cancer cell invasion and migration.
Neoplasms
Sodium 4-phenylbutyrate protects against liver ischemia reperfusion injury by inhibition of endoplasmic reticulum-stress mediated apoptosis.
Neoplasms
Sonic Hedgehog-GLI Family Zinc Finger 1 Signaling Pathway Promotes the Growth and Migration of Pancreatic Cancer Cells by Regulating the Transcription of Eukaryotic Translation Initiation Factor 5A2.
Neoplasms
SRC tyrosine kinase activates the YAP/TAZ axis and thereby drives tumor growth and metastasis.
Neoplasms
Sst2, a negative regulator of pheromone signaling in the yeast Saccharomyces cerevisiae: expression, localization, and genetic interaction and physical association with Gpa1 (the G-protein alpha subunit).
Neoplasms
Stability of eukaryotic translation initiation factor 4E mRNA is regulated by HuR, and this activity is dysregulated in cancer.
Neoplasms
STAT1 Promotes KRAS Colon Tumor Growth and Susceptibility to Pharmacological Inhibition of Translation Initiation Factor eIF4A.
Neoplasms
Statin-dependent suppression of the Akt/mammalian target of rapamycin signaling cascade and programmed cell death 4 up-regulation in renal cell carcinoma.
Neoplasms
Structural rationale for the cross-resistance of tumor cells bearing the A399V variant of elongation factor eEF1A1 to the structurally unrelated didemnin B, ternatin, nannocystin A and ansatrienin B.
Neoplasms
Structure and function of IQ-domain GTPase-activating protein 1 and its association with tumor progression (Review).
Neoplasms
Structure and functions of the translation initiation factor eIF4E and its role in cancer development and treatment.
Neoplasms
Structure-Activity Relationship Studies of Mitogen Activated Protein Kinase Interacting Kinase (MNK) 1 and 2 and BCR-ABL1 Inhibitors Targeting Chronic Myeloid Leukemic Cells.
Neoplasms
Suppression Of ?-catenin Nuclear Translocation By CGP57380 Decelerates Poor Progression And Potentiates Radiation-Induced Apoptosis in Nasopharyngeal Carcinoma.
Neoplasms
Suppression of antiviral innate immunity by sunitinib enhances oncolytic virotherapy.
Neoplasms
Suppression of bcr-abl synthesis by siRNAs or tyrosine kinase activity by Glivec alters different oncogenes, apoptotic/antiapoptotic genes and cell proliferation factors (microarray study).
Neoplasms
Suppression of Programmed Cell Death 4 (PDCD4) Protein Expression by BCR-ABL-regulated Engagement of the mTOR/p70 S6 Kinase Pathway.
Neoplasms
Synthesis of 7-benzylguanosine cap-analogue conjugates for eIF4E targeted degradation.
Neoplasms
Systematic Investigation of mRNA N 6-Methyladenosine Machinery in Primary Prostate Cancer.
Neoplasms
Systematically profiling the expression of eIF3 subunits in glioma reveals the expression of eIF3i has prognostic value in IDH-mutant lower grade glioma.
Neoplasms
Systemic Expression Analysis Reveals Prognostic Significance of WIPI3 in Hepatocellular Carcinoma.
Neoplasms
Targeting ?-catenin in hepatocellular cancers induced by coexpression of mutant ?-catenin and K-Ras in mice.
Neoplasms
Targeting eIF3f Suppresses the Growth of Prostate Cancer Cells by Inhibiting Akt Signaling.
Neoplasms
Targeting eIF4E inhibits growth, survival and angiogenesis in retinoblastoma and enhances efficacy of chemotherapy.
Neoplasms
Targeting eIF4E signaling with ribavirin as a sensitizing strategy for ovarian cancer.
Neoplasms
Targeting of protein translation as a new treatment paradigm for prostate cancer.
Neoplasms
TCEAL2 as a Tumor Suppressor in Renal Cell Carcinoma is Associated with the Good Prognosis of Patients.
Neoplasms
The A/G allele of eIF3a rs3740556 predicts platinum-based chemotherapy resistance in lung cancer patients.
Neoplasms
The Akt/mammalian target of rapamycin pathway is activated and associated with adverse prognosis in soft tissue leiomyosarcomas.
Neoplasms
The Alpha Subunit of Eukaryotic Initiation Factor (eIF) 2B is Requisite for eIF2-Mediated Translational Suppression of Vesicular Stomatitis Virus.
Neoplasms
The cellular response to ectopic overexpression of the tuberous sclerosis genes, TSC1 and TSC2: a proteomic approach.
Neoplasms
The DLC-1 -29A/T polymorphism is not associated with nasopharyngeal carcinoma risk in Chinese population.
Neoplasms
The downregulation of Rap1 GTPase-activating protein is associated with a poor prognosis in colorectal cancer and may impact on tumor progression.
Neoplasms
The elongin B ubiquitin homology domain. Identification of Elongin B sequences important for interaction with Elongin C.
Neoplasms
The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families.
Neoplasms
The Eukaryotic Translation Initiation Factor 4E (eIF4E) as a Therapeutic Target for Cancer.
Neoplasms
The eukaryotic translation initiation factor eIF4E is a direct transcriptional target of NF-?B and is aberrantly regulated in Acute Myeloid Leukemia.
Neoplasms
The expression levels of the translational factors eEF1A 1/2 correlate with cell growth but not apoptosis in hepatocellular carcinoma cell lines with different differentiation grade.
Neoplasms
The expression of eukaryotic translation initiation factor 3B and its correlation with tumor characteristics as well as prognosis in non-small cell lung cancer patients: a retrospective study.
Neoplasms
The expression profile and prognostic significance of eukaryotic translation elongation factors in different cancers.
Neoplasms
The helicase protein DHX29 promotes translation initiation, cell proliferation, and tumorigenesis.
Neoplasms
The human Y-encoded testis-specific protein interacts functionally with eukaryotic translation elongation factor eEF1A, a putative oncoprotein.
Neoplasms
The interaction between interferon-induced protein with tetratricopeptide repeats-1 and eukaryotic elongation factor-1A.
Neoplasms
The intracellular stability of DLC1 is regulated by the 26S proteasome in human hepatocellular carcinoma cell line Hep3B.
Neoplasms
The lethal prune/Killer-of-prune interaction of Drosophila causes a syndrome resembling human neurofibromatosis (NF1).
Neoplasms
The more basic isoform of eEF1A relates to tumour cell phenotype and is modulated by hyper-proliferative/differentiating stimuli in normal lymphocytes and CCRF-CEM T-lymphoblasts.
Neoplasms
The neurofibromatosis type 1 gene product neurofibromin enhances cell motility by regulating actin filament dynamics via the Rho-ROCK-LIMK2-cofilin pathway.
Neoplasms
The processed isoform of the translation termination factor eRF3 localizes to the nucleus to interact with the ARF tumor suppressor.
Neoplasms
The prohibitin-binding compound fluorizoline affects multiple components of the translational machinery and inhibits protein synthesis.
Neoplasms
The proliferation of colorectal cancer cells is suppressed by silencing of EIF3H.
Neoplasms
The RhoGAP protein Deleted in Liver Cancer 3 (DLC3) is essential for adherens junctions integrity.
Neoplasms
The Role of Dynamics and Allostery in the Inhibition of the eIF4E/eIF4G Translation Initiation Factor Complex.
Neoplasms
The Role of eIF4E in Response and Acquired Resistance to Vemurafenib in Melanoma.
Neoplasms
The role of translation elongation factor eEF1A in intracellular alkalinization-induced tumor cell growth.
Neoplasms
The somatostatin analogue octreotide inhibits growth of small intestine neuroendocrine tumour cells.
Neoplasms
The TAT-RasGAP317-326 anti-cancer peptide can kill in a caspase-, apoptosis-, and necroptosis-independent manner.
Neoplasms
The translation elongation factor 1A in tumorigenesis, signal transduction and apoptosis: review article.
Neoplasms
The translation elongation factor eEF2 is a novel tumor?associated antigen overexpressed in various types of cancers.
Neoplasms
The translation initiation factor eIF3-p48 subunit is encoded by int-6, a site of frequent integration by the mouse mammary tumor virus genome.
Neoplasms
The translation initiation factor eIF3i up-regulates vascular endothelial growth factor A, accelerates cell proliferation, and promotes angiogenesis in embryonic development and tumorigenesis.
Neoplasms
The TSC1 and TSC2 tumor suppressors are required for proper ER stress response and protect cells from ER stress-induced apoptosis.
Neoplasms
The tuberous sclerosis 2 gene is expressed at high levels in the cerebellum and developing spinal cord.
Neoplasms
The tumor suppressor eIF3e mediates calcium-dependent internalization of the L-type calcium channel CaV1.2.
Neoplasms
The Ubiquitin-like Protein FAT10 Stabilizes eEF1A1 Expression to Promote Tumor Proliferation in a Complex Manner.
Neoplasms
Therapeutic suppression of translation initiation factor eIF4E expression reduces tumor growth without toxicity.
Neoplasms
Therapeutic suppression of translation initiation modulates chemosensitivity in a mouse lymphoma model.
Neoplasms
Transcription elongation factor A-like 7, regulated by miR-758-3p inhibits the progression of melanoma through decreasing the expression levels of c-Myc and AKT1.
Neoplasms
Transcription elongation factor SII (TCEA) maps to human chromosome 3p22 --> p21.3.
Neoplasms
Translation elongation factor eEF1B? is identified as a novel prognostic marker of gastric cancer.
Neoplasms
Translation initiation factor eIF-4G is immunogenic, overexpressed, and amplified in patients with squamous cell lung carcinoma.
Neoplasms
Translation initiation factor eIF3b expression in human cancer and its role in tumor growth and lung colonization.
Neoplasms
Translation initiation factor eIF4E is a target for tumor cell radiosensitization.
Neoplasms
Translation of ODC mRNA and polyamine transport are suppressed in ras-transformed CREF cells by depleting translation initiation factor 4E.
Neoplasms
Translational control in the tumor microenvironment promotes lung metastasis: Phosphorylation of eIF4E in neutrophils.
Neoplasms
Translationally controlled tumor protein acts as a guanine nucleotide dissociation inhibitor on the translation elongation factor eEF1A.
Neoplasms
Tumor Cell Migration and Invasion Are Enhanced by Depletion of Rap1 GTPase-activating Protein (Rap1GAP).
Neoplasms
Tumor necrosis factor-alpha downregulates endothelial nitric oxide synthase mRNA stability via translation elongation factor 1-alpha 1.
Neoplasms
Tumor suppression by PTEN requires the activation of the PKR-eIF2alpha phosphorylation pathway.
Neoplasms
Tumor Suppression of Ras GTPase-Activating Protein RASA5 through Antagonizing Ras Signaling Perturbation in Carcinomas.
Neoplasms
Tumor suppressor gene 14-3-3sigma is down-regulated whereas the proto-oncogene translation elongation factor 1delta is up-regulated in non-small cell lung cancers as identified by proteomic profiling.
Neoplasms
Tumor suppressor p16INK4a inhibits cancer cell growth by down-regulating eEF1A2 through a direct interaction.
Neoplasms
Tumor suppressor Pdcd4 attenuates Sin1 translation to inhibit invasion in colon carcinoma.
Neoplasms
Two genome-wide association studies of aggressive prostate cancer implicate putative prostate tumor suppressor gene DAB2IP.
Neoplasms
Tyrosine phosphorylation of beta2-chimaerin by Src-family kinase negatively regulates its Rac-specific GAP activity.
Neoplasms
Understanding and Targeting the Eukaryotic Translation Initiation Factor eIF4E in Head and Neck Cancer.
Neoplasms
Upconversion nanoparticles loaded with eIF4E siRNA and platinum(iv) prodrug to sensitize platinum based chemotherapy for laryngeal cancer and bioimaging.
Neoplasms
Upregulated expression of the genes encoding translation initiation factors eIF-4E and eIF-2alpha in transformed cells.
Neoplasms
Upregulation of eukaryotic translation initiation factor 4E associates with a poor prognosis in gallbladder cancer and promotes cell proliferation in vitro and in vivo.
Neoplasms
Use of the human EF-1alpha promoter for expression can significantly increase success in establishing stable cell lines with consistent expression: a study using the tetracycline-inducible system in human cancer cells.
Neoplasms
Vitronectin-?v?3 integrin engagement directs hypoxia-resistant mTOR activity and sustained protein synthesis linked to invasion by breast cancer cells.
Neoplasms
WLS/wntless is essential in controlling dendritic cell homeostasis via a WNT signaling-independent mechanism.
Neoplasms
Worldwide Population Structure, Long-Term Demography, and Local Adaptation of Helicobacter pylori.
Neoplasms
Zinc supplementation is required for the cytotoxic and immunogenic effects of chemotherapy in chemoresistant p53-functionally deficient cells.
Neoplasms
[Expression and its clinical significance of eIF4E in non-small cell lung cancer].
Neoplasms
[Searching for genes interacting with human PCIA1 gene by using the bacterial two-hybrid system]
Neoplasms, Germ Cell and Embryonal
The human Y-encoded testis-specific protein interacts functionally with eukaryotic translation elongation factor eEF1A, a putative oncoprotein.
Neoplasms, Glandular and Epithelial
Expression of translation initiation factor eIF-2alpha is increased in benign and malignant melanocytic and colonic epithelial neoplasms.
Neoplasms, Squamous Cell
Antisense RNA to eIF4E suppresses oncogenic properties of a head and neck squamous cell carcinoma cell line.
Neoplasms, Squamous Cell
Differential expression of TCEAL1 in esophageal cancers by custom cDNA microarray analysis.
Nervous System Diseases
Analysis of the subunit organization of the eIF2B complex reveals new insights into its structure and regulation.
Nervous System Diseases
Cellular dynamics of the negative transcription elongation factor NELF.
Nervous System Diseases
eIF2B: recent structural and functional insights into a key regulator of translation.
Nervous System Diseases
Fasting and Systemic Insulin Signaling Regulate Phosphorylation of Brain Proteins That Modulate Cell Morphology and Link to Neurological Disorders.
Nervous System Diseases
Glial pathology in a novel spontaneous mutant mouse of the Eif2b5 gene: a vanishing white matter disease model.
Nervous System Diseases
Identification of Residues That Underpin Interactions within the Eukaryotic Initiation Factor (eIF2) 2B Complex.
Nervous System Diseases
NELF interacts with CBC and participates in 3' end processing of replication-dependent histone mRNAs.
Nervous System Neoplasms
R-Ras subfamily proteins elicit distinct physiologic effects and phosphoproteome alterations in neurofibromin-null MPNST cells.
Neuroblastoma
Cloning of a human antibody directed against human neuroblastoma cells and specific for human translation elongation factor 1alpha.
Neuroblastoma
Computer-assisted image analysis can aid the prognostication of advanced-stage neuroblastomas.
Neuroblastoma
Endoplasmic reticulum stress-mediated neuronal apoptosis by acrylamide exposure.
Neuroblastoma
ERdj5 sensitizes neuroblastoma cells to endoplasmic reticulum stress-induced apoptosis.
Neuroblastoma
Eukaryotic Translation Initiation Factor 4AI: A Potential Novel Target in Neuroblastoma.
Neuroblastoma
Involvement of double-stranded RNA-dependent protein kinase and phosphorylation of eukaryotic initiation factor-2alpha in neuronal degeneration.
Neuroblastoma
MLIF Alleviates SH-SY5Y Neuroblastoma Injury Induced by Oxygen-Glucose Deprivation by Targeting Eukaryotic Translation Elongation Factor 1A2.
Neuroblastoma
Morphologic, Molecular, and Taxonomic Evolution of Renal Cell Carcinoma: A Conceptual Perspective With Emphasis on Updates to the 2016 World Health Organization Classification.
Neuroblastoma
PERK is activated differentially in peripheral organs following cardiac arrest and resuscitation.
Neuroblastoma
Proteomic Analysis on Anti-Proliferative and Apoptosis Effects of Curcumin Analog, 1,5-bis(4-Hydroxy-3-Methyoxyphenyl)-1,4-Pentadiene-3-One-Treated Human Glioblastoma and Neuroblastoma Cells.
Neuroblastoma
Regulation of endoplasmic reticulum stress-induced cell death by ATF4 in neuroectodermal tumor cells.
Neuroblastoma
Synergy between loss of NF1 and overexpression of MYCN in neuroblastoma is mediated by the GAP-related domain.
Neurodegenerative Diseases
A yeast purification system for human translation initiation factors eIF2 and eIF2B? and their use in the diagnosis of CACH/VWM disease.
Neurodegenerative Diseases
C9orf72 ALS-FTD: recent evidence for dysregulation of the autophagy-lysosome pathway at multiple levels.
Neurodegenerative Diseases
Connecting the dots in Huntington's disease with protein interaction networks.
Neurodegenerative Diseases
eIF2B and the Integrated Stress Response: A Structural and Mechanistic View.
Neurodegenerative Diseases
Expression, purification, and crystallization of Schizosaccharomyces pombe eIF2B.
Neurodegenerative Diseases
Foetal onset of EIF2B related disorder in two siblings: cerebellar hypoplasia with absent Bergmann glia and severe hypomyelination.
Neurodegenerative Diseases
Novel mechanisms of eIF2B action and regulation by eIF2? phosphorylation.
Neurodegenerative Diseases
Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response.
Neurodegenerative Diseases
Proteome response to ochratoxin A-induced apoptotic cell death in mouse hippocampal HT22 cells.
Neurodegenerative Diseases
Proteomics-level analysis of myelin formation and regeneration in a mouse model for Vanishing White Matter disease.
Neurodegenerative Diseases
Regulation of antioxidant metabolism by translation initiation factor 2alpha.
Neurodegenerative Diseases
Somatostatin, neuronal vulnerability and behavioral emotionality.
Neurodegenerative Diseases
Targeting the kinase insert loop of PERK selectively modulates PERK signaling without systemic toxicity in mice.
Neurodegenerative Diseases
The Integrated Stress Response and Phosphorylated Eukaryotic Initiation Factor 2? in Neurodegeneration.
Neurodegenerative Diseases
The small molecule ISRIB rescues the stability and activity of Vanishing White Matter Disease eIF2B mutant complexes.
Neurodegenerative Diseases
Translational control by 5'-untranslated regions of eukaryotic mRNAs.
Neurofibromatoses
A conserved alternative splice in the von Recklinghausen neurofibromatosis (NF1) gene produces two neurofibromin isoforms, both of which have GTPase-activating protein activity.
Neurofibromatoses
A functional assay for heterozygous mutations in the GTPase activating protein related domain of the neurofibromatosis type 1 gene.
Neurofibromatoses
Absence of Neurofibromin Induces an Oncogenic Metabolic Switch via Mitochondrial ERK-Mediated Phosphorylation of the Chaperone TRAP1.
Neurofibromatoses
Alternative splicing of neurofibromatosis type 1 gene transcript in malignant brain tumors: PCR analysis of frozen-section mRNA.
Neurofibromatoses
Analysis of the GAP-related domain of the neurofibromatosis type 1 (NF1) gene in childhood brain tumors.
Neurofibromatoses
Assessment of the potential pathogenicity of missense mutations identified in the GTPase-activating protein (GAP)-related domain of the neurofibromatosis type-1 (NF1) gene.
Neurofibromatoses
Catalytic properties, tissue and intracellular distribution of neurofibromin.
Neurofibromatoses
Cross-species analyses identify the BNIP-2 and Cdc42GAP homology (BCH) domain as a distinct functional subclass of the CRAL_TRIO/Sec14 superfamily.
Neurofibromatoses
Differences in GTPase-activating protein activity between liver tumors and normal liver tissue in mice.
Neurofibromatoses
ERK Inhibition Rescues Defects in Fate Specification of Nf1-Deficient Neural Progenitors and Brain Abnormalities.
Neurofibromatoses
Identification and characterization of the neurofibromatosis type 1 protein product.
Neurofibromatoses
Identification of neurofibromatosis type I gene product as an insoluble GTPase-activating protein toward ras p21.
Neurofibromatoses
Molecular cloning of a cDNA coding for neurofibromatosis type 1 protein isoform lacking the domain related to ras GTPase-activating protein.
Neurofibromatoses
Multiple transcripts of the neurofibromatosis type 1 gene in human brain and in brain tumours.
Neurofibromatoses
Neurofibromatosis type I tumor suppressor neurofibromin regulates neuronal differentiation via its GTPase-activating protein function toward Ras.
Neurofibromatoses
R-Ras subfamily proteins elicit distinct physiologic effects and phosphoproteome alterations in neurofibromin-null MPNST cells.
Neurofibromatoses
Rac1 mediates the osteoclast gains-in-function induced by haploinsufficiency of Nf1.
Neurofibromatoses
Reduced growth of Drosophila neurofibromatosis 1 mutants reflects a non-cell-autonomous requirement for GTPase-Activating Protein activity in larval neurons.
Neurofibromatoses
Specific expression of the neurofibromatosis type 1 gene (NF1) in the hamster Schwann cell.
Neurofibromatoses
Sst2, a negative regulator of pheromone signaling in the yeast Saccharomyces cerevisiae: expression, localization, and genetic interaction and physical association with Gpa1 (the G-protein alpha subunit).
Neurofibromatoses
The GAP-related domain of the neurofibromatosis type 1 gene product interacts with ras p21.
Neurofibromatoses
The neurofibromatosis type 1 gene product neurofibromin enhances cell motility by regulating actin filament dynamics via the Rho-ROCK-LIMK2-cofilin pathway.
Neurofibromatoses
The NF1 locus encodes a protein functionally related to mammalian GAP and yeast IRA proteins.
Neurofibromatoses
The RasGAP proteins Ira2 and neurofibromin are negatively regulated by Gpb1 in yeast and ETEA in humans.
Neurofibromatosis 1
A functional assay for heterozygous mutations in the GTPase activating protein related domain of the neurofibromatosis type 1 gene.
Neurofibromatosis 1
Absence of Neurofibromin Induces an Oncogenic Metabolic Switch via Mitochondrial ERK-Mediated Phosphorylation of the Chaperone TRAP1.
Neurofibromatosis 1
Alternative splicing of neurofibromatosis type 1 gene transcript in malignant brain tumors: PCR analysis of frozen-section mRNA.
Neurofibromatosis 1
Catalytic properties, tissue and intracellular distribution of neurofibromin.
Neurofibromatosis 1
Differences in GTPase-activating protein activity between liver tumors and normal liver tissue in mice.
Neurofibromatosis 1
ERK Inhibition Rescues Defects in Fate Specification of Nf1-Deficient Neural Progenitors and Brain Abnormalities.
Neurofibromatosis 1
Identification and characterization of the neurofibromatosis type 1 protein product.
Neurofibromatosis 1
Identification of neurofibromatosis type I gene product as an insoluble GTPase-activating protein toward ras p21.
Neurofibromatosis 1
Molecular cloning of a cDNA coding for neurofibromatosis type 1 protein isoform lacking the domain related to ras GTPase-activating protein.
Neurofibromatosis 1
Neurofibromatosis type I tumor suppressor neurofibromin regulates neuronal differentiation via its GTPase-activating protein function toward Ras.
Neurofibromatosis 1
R-Ras subfamily proteins elicit distinct physiologic effects and phosphoproteome alterations in neurofibromin-null MPNST cells.
Neurofibromatosis 1
Rac1 mediates the osteoclast gains-in-function induced by haploinsufficiency of Nf1.
Neurofibromatosis 1
Reduced growth of Drosophila neurofibromatosis 1 mutants reflects a non-cell-autonomous requirement for GTPase-Activating Protein activity in larval neurons.
Neurofibromatosis 1
Specific expression of the neurofibromatosis type 1 gene (NF1) in the hamster Schwann cell.
Neurofibromatosis 1
The GAP-related domain of the neurofibromatosis type 1 gene product interacts with ras p21.
Neurofibromatosis 1
The neurofibromatosis type 1 gene product neurofibromin enhances cell motility by regulating actin filament dynamics via the Rho-ROCK-LIMK2-cofilin pathway.
Neurofibromatosis 1
The RasGAP proteins Ira2 and neurofibromin are negatively regulated by Gpb1 in yeast and ETEA in humans.
Neurofibrosarcoma
Combined Inhibition of SHP2 and MEK Is Effective in Models of NF1-Deficient Malignant Peripheral Nerve Sheath Tumors.
Neurofibrosarcoma
Malignant peripheral nerve sheath tumors with high and low Ras-GTP are permissive for oncolytic herpes simplex virus mutants.
Neurofibrosarcoma
Reduced expression of neurofibromin in the soft tissue tumours obtained from patients with neurofibromatosis type I.
Neuroinflammatory Diseases
Immune and gene expression profiling during tacrolimus to everolimus conversion early after liver transplantation.
Nevus
Discrimination of melanocytic tumors by cDNA array hybridization of tissues prepared by laser pressure catapulting.
Newcastle Disease
Genetic responses of inbred chicken lines illustrate importance of eIF2 family and immune-related genes in resistance to Newcastle disease virus.
Newcastle Disease
Sendai virus C protein plays a role in restricting PKR activation by limiting the generation of intracellular double-stranded RNA.
Niemann-Pick Disease, Type C
New insights into the interplay between autophagy, gut microbiota and inflammatory responses in IBD.
Niemann-Pick Diseases
New insights into the interplay between autophagy, gut microbiota and inflammatory responses in IBD.
Non-alcoholic Fatty Liver Disease
Jiang-Zhi granules decrease sensitivity to low-dose CCl4 induced liver injury in NAFLD rats through reducing endoplasmic reticulum stress.
Non-alcoholic Fatty Liver Disease
Lipotoxicity-induced STING1 activation stimulates MTORC1 and restricts hepatic lipophagy.
Non-alcoholic Fatty Liver Disease
The marine compound and elongation factor 1A1 inhibitor, didemnin B, provides benefit in western diet-induced non-alcoholic fatty liver disease.
Non-alcoholic Fatty Liver Disease
The unfolded protein response regulates hepatic autophagy by sXBP1-mediated activation of TFEB.
Non-alcoholic Fatty Liver Disease
Treatment with didemnin B, an elongation factor 1A inhibitor, improves hepatic lipotoxicity in obese mice.
Obesity
Mitochondrial mRNA translation initiation contributes to oxidative metabolism in the myocardia of aged, obese mice.
Obesity
The unfolded protein response regulates hepatic autophagy by sXBP1-mediated activation of TFEB.
Oculocerebrorenal Syndrome
Role of oculocerebrorenal syndrome of Lowe (OCRL) protein in megakaryocyte maturation, platelet production and functions: a study in patients with Lowe syndrome.
Onychomycosis
Translation elongation factor 1-alpha gene as a marker for diagnosing of candidal onychomycosis.
Optic Nerve Diseases
Rescue of Glaucomatous Neurodegeneration by Differentially Modulating Neuronal Endoplasmic Reticulum Stress Molecules.
Optic Nerve Injuries
Rescue of Glaucomatous Neurodegeneration by Differentially Modulating Neuronal Endoplasmic Reticulum Stress Molecules.
Osteoarthritis
CircRNA circ-IQGAP1 Knockdown Alleviates Interleukin-1?-Induced Osteoarthritis Progression via Targeting miR-671-5p/TCF4.
Osteoarthritis
Down-regulation of Rac GTPase-activating protein OCRL1 causes aberrant activation of Rac1 in osteoarthritis development.
Osteoarthritis
MTORC1 coordinates the autophagy and apoptosis signaling in articular chondrocytes in osteoarthritic temporomandibular joint.
Osteoporosis
Cdc42 GTPase-activating protein deficiency promotes genomic instability and premature aging-like phenotypes.
Osteosarcoma
EEF1D overexpression promotes osteosarcoma cell proliferation by facilitating Akt-mTOR and Akt-bad signaling.
Osteosarcoma
Identification of valid reference housekeeping genes for gene expression analysis in tumor neovascularization studies.
Osteosarcoma
Networking of differentially expressed genes in human cancer cells resistant to methotrexate.
Osteosarcoma
Rho GTPase-activating protein 35 rs1052667 polymorphism and osteosarcoma risk and prognosis.
Osteosarcoma
Silencing of translation initiation factor eIF3b promotes apoptosis in osteosarcoma cells.
Osteosarcoma
Slit-Robo GTPase-Activating Protein 2 as a metastasis suppressor in osteosarcoma.
Osteosarcoma
Up-regulation of microRNA-496 suppresses proliferation, invasion, migration and in vivo tumorigenicity of human osteosarcoma cells by targeting eIF4E.
Ovarian Neoplasms
Autophagy and protein kinase RNA-like endoplasmic reticulum kinase (PERK)/eukaryotic initiation factor 2 alpha kinase (eIF2?) pathway protect ovarian cancer cells from metformin-induced apoptosis.
Ovarian Neoplasms
Characterization of a Putative Ovarian Oncogene, Elongation Factor 1{alpha}, Isolated by Panning a Synthetic Phage Display Single-Chain Variable Fragment Library with Cultured Human Ovarian Cancer Cells.
Ovarian Neoplasms
Downregulation of TCEAL7 expression induces CCND1 expression in non-small cell lung cancer.
Ovarian Neoplasms
Effects of EIF3B gene downregulation on apoptosis and proliferation of human ovarian cancer SKOV3 and HO-8910 cells.
Ovarian Neoplasms
Eukaryotic initiation factor 3, subunit C silencing inhibits cell proliferation and promotes apoptosis in human ovarian cancer cells.
Ovarian Neoplasms
Eukaryotic translation initiation factor 3 subunit D overexpression is associated with the occurrence and development of ovarian cancer.
Ovarian Neoplasms
Gamendazole, an orally active indazole carboxylic acid male contraceptive agent, targets HSP90AB1 (HSP90BETA) and EEF1A1 (eEF1A), and stimulates Il1a transcription in rat Sertoli cells.
Ovarian Neoplasms
Inhibition of ovarian cancer growth by a tumor-targeting peptide that binds eukaryotic translation initiation factor 4E.
Ovarian Neoplasms
IQGAP1 Is Involved in Enhanced Aggressive Behavior of Epithelial Ovarian Cancer Stem Cell-Like Cells During Differentiation.
Ovarian Neoplasms
Nitrosative stress-induced s-glutathionylation of protein disulfide isomerase leads to activation of the unfolded protein response.
Ovarian Neoplasms
Protein elongation factor EEF1A2 is a putative oncogene in ovarian cancer.
Ovarian Neoplasms
Puncta intended: connecting the dots between autophagy and cell stress networks.
Ovarian Neoplasms
Resveratrol suppresses growth of human ovarian cancer cells in culture and in a murine xenograft model: eukaryotic elongation factor 1A2 as a potential target.
Ovarian Neoplasms
Suppression of the GTPase-activating protein RGS10 increases Rheb-GTP and mTOR signaling in ovarian cancer cells.
Ovarian Neoplasms
Targeting eIF4E signaling with ribavirin as a sensitizing strategy for ovarian cancer.
Ovarian Neoplasms
The m6A reader YTHDF1 promotes ovarian cancer progression via augmenting EIF3C translation.
Ovarian Neoplasms
The prognostic significance of elongation factor eEF1A2 in ovarian cancer.
Ovarian Neoplasms
Translation elongation factor eEF1A2 is a potential oncoprotein that is overexpressed in two-thirds of breast tumours.
Overweight
Maternal Overweight Induced by a Diet with High Content of Saturated Fat Activates Placental mTOR and eIF2alpha Signaling and Increases Fetal Growth in Rats.
Pancreatic Neoplasms
Antitumor alkyl-lysophospholipid analog edelfosine induces apoptosis in pancreatic cancer by targeting endoplasmic reticulum.
Pancreatic Neoplasms
EEF1A2 interacts with HSP90AB1 to promote lung adenocarcinoma metastasis via enhancing TGF-?/SMAD signalling.
Pancreatic Neoplasms
Eukaryotic Translation Initiation Factor 3 Subunit B Is a Promoter in the Development and Progression of Pancreatic Cancer.
Pancreatic Neoplasms
Eukaryotic Translation Initiation Factor 3a (eIF3a) Promotes Cell Proliferation and Motility in Pancreatic Cancer.
Pancreatic Neoplasms
Eukaryotic Translation Initiation Factor 5A (EIF5A) Regulates Pancreatic Cancer Metastasis by Modulating RhoA and Rho-associated Kinase (ROCK) Protein Expression Levels.
Pancreatic Neoplasms
Identification of a novel small molecule that inhibits deacetylase but not defatty-acylase reaction catalysed by SIRT2.
Pancreatic Neoplasms
Imexon Induces an Oxidative Endoplasmic Reticulum Stress Response in Pancreatic Cancer Cells.
Pancreatic Neoplasms
MD11-mediated delivery of recombinant eIF3f induces melanoma and colorectal carcinoma cell death.
Pancreatic Neoplasms
Networking of differentially expressed genes in human cancer cells resistant to methotrexate.
Pancreatic Neoplasms
Sonic Hedgehog-GLI Family Zinc Finger 1 Signaling Pathway Promotes the Growth and Migration of Pancreatic Cancer Cells by Regulating the Transcription of Eukaryotic Translation Initiation Factor 5A2.
Pancreatic Neoplasms
The N-Terminal Domain of G3BP Enhances Cell Motility and Invasion by Posttranscriptional Regulation of BART.
Pancreatic Neoplasms
The overexpression of elongation factor 1 gamma mRNA in gastric carcinoma.
Pancreatic Neoplasms
The tumor suppressive role of eIF3f and its function in translation inhibition and rRNA degradation.
Pancreatic Neoplasms
Translational reprogramming marks adaptation to asparagine restriction in cancer.
Pancreatic Neoplasms
Up-Regulation of circEIF6 Contributes to Pancreatic Cancer Development Through Targeting miR-557/SLC7A11/PI3K/AKT Signaling.
Pancreatic Neoplasms
Updated therapeutic outcome for patients with periampullary and pancreatic cancer related to recent translational research.
Pancreatic Neoplasms
Upregulation of ARHGAP30 attenuates pancreatic cancer progression by inactivating the ?-catenin pathway.
Pancreatitis
Caerulein-induced acute pancreatitis inhibits protein synthesis through effects on eIF2B and eIF4F.
Pancreatitis
Mice lacking the transcription factor Mist1 exhibit an altered stress response and increased sensitivity to caerulein-induced pancreatitis.
Pancreatitis
Phosphorylation of the MNK1 substrate eIF4E is not required for response to acute pancreatitis.
Pancreatitis, Acute Necrotizing
An evaluation of potential reference genes for stability of expression in two salmonid cell lines after infection with either Piscirickettsia salmonis or IPNV.
Pancreatitis, Acute Necrotizing
Characterization of rainbow trout and zebrafish eukaryotic initiation factor 2alpha and its response to endoplasmic reticulum stress and IPNV infection.
Papilloma
Persistent expression of foreign genes in cultured hepatocytes: expression vectors.
Papillomavirus Infections
Control of alpha subunit of eukaryotic translation initiation factor 2 (eIF2 alpha) phosphorylation by the human papillomavirus type 18 E6 oncoprotein: implications for eIF2 alpha-dependent gene expression and cell death.
Papillomavirus Infections
TBC1D5-Catalyzed Cycling of Rab7 Is Required for Retromer-Mediated Human Papillomavirus Trafficking during Virus Entry.
Paralysis
Regulation of internal ribosomal entry site-mediated translation by phosphorylation of the translation initiation factor eIF2alpha.
Parkinson Disease
A chemical genomics-aggrephagy integrated method studying functional analysis of autophagy inducers.
Parkinson Disease
Comparative mRNA Expression of eEF1A Isoforms and a PI3K/Akt/mTOR Pathway in a Cellular Model of Parkinson's Disease.
Parkinson Disease
D620N mutation in the VPS35 gene and R1205H mutation in the EIF4G1 gene are uncommon in the Greek population.
Parkinson Disease
EIF4G1 in familial Parkinson's disease: pathogenic mutations or rare benign variants?
Parkinson Disease
EIF4G1 is neither a strong nor a common risk factor for Parkinson's disease: evidence from large European cohorts.
Parkinson Disease
EIF4G1 R1205H and VPS35 D620N mutations are rare in Parkinson's disease from South Africa.
Parkinson Disease
Eukaryotic translation initiation factor 4-?, 1 gene mutations are rare in Parkinson's disease among Taiwanese.
Parkinson Disease
Mitochondrial translation initiation factor 3 gene polymorphism associated with Parkinson's disease.
Parkinson Disease
Mitochondrial translation initiation factor 3 polymorphism and Parkinson's disease.
Parkinson Disease
Organelle-specific autophagy in inflammatory diseases: a potential therapeutic target underlying the quality control of multiple organelles.
Parkinson Disease
Possible involvement of a mitochondrial translation initiation factor 3 variant causing decreased mRNA levels in Parkinson's disease.
Parkinson Disease
Variants in eukaryotic translation initiation factor 4G1 in sporadic Parkinson's disease.
Parkinson Disease
VPS35 and EIF4G1 mutations are rare in Parkinson's disease among Indians.
Parkinson Disease
VPS35 Asp620Asn and EIF4G1 Arg1205His mutations are rare in Parkinson disease from Southwest China.
Parkinson Disease
Whole exome sequencing of rare variants in EIF4G1 and VPS35 in Parkinson disease.
Parkinsonian Disorders
Advances in the Genetics of Parkinson's Disease: A Guide for the Clinician.
Parkinsonian Disorders
Sequence variants in eukaryotic translation initiation factor 4-gamma (eIF4G1) are associated with Lewy body dementia.
Parkinsonian Disorders
Study of the genetic variability in a Parkinson's Disease gene: EIF4G1.
Persistent Infection
Autoantibody profiles in the sera of patients with Q fever: characterization of antigens by immunofluorescence, immunoblot and sequence analysis.
Persistent Infection
Hepatitis C virus NS4A inhibits cap-dependent and the viral IRES-mediated translation through interacting with eukaryotic elongation factor 1A.
Persistent Infection
Mycoplasma genitalium rapidly disseminates to the upper reproductive tracts and knees of female mice following vaginal inoculation.
Pheochromocytoma
Collapsin response mediator protein-2 regulates neurite formation by modulating tubulin GTPase activity.
Phytoplasma Disease
Expression Stabilities of Candidate Reference Genes for RT-qPCR in Chinese Jujube (Ziziphus jujuba Mill.) under a Variety of Conditions.
Phytoplasma Disease
Sequence and RFLP analysis of the elongation factor Tu gene used in differentiation and classification of phytoplasmas.
Picornaviridae Infections
Caspases are not involved in the cleavage of translation initiation factor eIF4GI during picornavirus infection.
Plasmacytoma
Heterogeneous nuclear ribonucleoprotein L-like (hnRNPLL) and elongation factor, RNA polymerase II, 2 (ELL2) are regulators of mRNA processing in plasma cells.
Pneumococcal Infections
Immunization with pneumococcal elongation factor Tu enhances serotype-independent protection against Streptococcus pneumoniae infection.
Pneumonia
A bronchoprotective role for Rgs2 in a murine model of lipopolysaccharide-induced airways inflammation.
Polycystic Kidney, Autosomal Dominant
Polycystin-2 down-regulates cell proliferation via promoting PERK-dependent phosphorylation of eIF2alpha.
Polymicrogyria
The R336Q mutation in human mitochondrial EFTu prevents the formation of an active mt-EFTu.GTP.aa-tRNA ternary complex.
Polymyositis
Identification of a novel autoantigen eukaryotic initiation factor 3 associated with polymyositis.
Porcine Reproductive and Respiratory Syndrome
MAMP (microbe-associated molecular pattern) triggered immunity in plants.
Porcine Reproductive and Respiratory Syndrome
Viral strategies for triggering and manipulating mitophagy.
Pre-Eclampsia
Int6/eIF3e Silencing Promotes Placenta Angiogenesis in a Rat Model of Pre-eclampsia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Potential molecules implicated in downstream signaling pathways of p185BCR-ABL in Ph+ ALL involve GTPase-activating protein, phospholipase C-gamma 1, and phosphatidylinositol 3'-kinase.
Premature Birth
Common Genetic Variants Link the Abnormalities in the Gut-Brain Axis in Prematurity and Autism.
Primary Ovarian Insufficiency
Screening for known mutations in EIF2B genes in a large panel of patients with premature ovarian failure.
Prion Diseases
Endoplasmic reticulum stress features are prominent in Alzheimer disease but not in prion diseases in vivo.
Prostatic Hyperplasia
In-silico identification and characterization of organic and inorganic chemical stress responding genes in yeast (Saccharomyces cerevisiae).
Prostatic Neoplasms
Activation of the EIF2?/ATF4 and ATF6 Pathways in DU-145 Cells by Boric Acid at the Concentration Reported in Men at the US Mean Boron Intake.
Prostatic Neoplasms
Amplification and overexpression of p40 subunit of eukaryotic translation initiation factor 3 in breast and prostate cancer.
Prostatic Neoplasms
An oncogene-tumor suppressor cascade drives metastatic prostate cancer by coordinately activating Ras and nuclear factor-kappaB.
Prostatic Neoplasms
Androgen signaling promotes translation of TMEFF2 in prostate cancer cells via phosphorylation of the ? subunit of the translation initiation factor 2.
Prostatic Neoplasms
Cell-specific induction of apoptosis by rationally designed bivalent aptamer-siRNA transcripts silencing eukaryotic elongation factor 2.
Prostatic Neoplasms
Development of a reactive stroma associated with prostatic intraepithelial neoplasia in EAF2 deficient mice.
Prostatic Neoplasms
Down-regulation of human DAB2IP gene expression mediated by polycomb Ezh2 complex and histone deacetylase in prostate cancer.
Prostatic Neoplasms
eIF5B regulates the expression of PD-L1 in prostate cancer cells by interacting with Wig1.
Prostatic Neoplasms
Eukaryotic Elongation Factor 2 (eEF2) is a Potential Biomarker of Prostate Cancer.
Prostatic Neoplasms
Eukaryotic translation initiation factor 3 subunit b is a novel oncogenic factor in prostate cancer.
Prostatic Neoplasms
Eukaryotic Translation Initiation Factor 4 Gamma 1 (eIF4G1) is upregulated during Prostate cancer progression and modulates cell growth and metastasis.
Prostatic Neoplasms
Eukaryotic translation initiation factor 5A2 is highly expressed in prostate cancer and predicts poor prognosis.
Prostatic Neoplasms
Expression of the Y-Encoded TSPY is Associated with Progression of Prostate Cancer.
Prostatic Neoplasms
Fibroblast growth factor and ornithine decarboxylase 5'UTRs enable preferential expression in human prostate cancer cells and in prostate tumors of PTEN(-/-) transgenic mice.
Prostatic Neoplasms
Inhibition of eukaryotic initiation factor 3B suppresses proliferation and promotes apoptosis of chronic myeloid leukemia cells.
Prostatic Neoplasms
Intratumoral Heterogeneity Determines the Expression of mTOR-pathway Proteins in Prostate Cancer.
Prostatic Neoplasms
Mapping and gene expression profile of the minimally overrepresented 8q24 region in prostate cancer.
Prostatic Neoplasms
Phenethyl isothiocyanate, a cancer chemopreventive constituent of cruciferous vegetables, inhibits cap-dependent translation by regulating the level and phosphorylation of 4E-BP1.
Prostatic Neoplasms
PRC17, a novel oncogene encoding a Rab GTPase-activating protein, is amplified in prostate cancer.
Prostatic Neoplasms
Regulation of tumor suppressor EAF2 polyubiquitination by ELL1 and SIAH2 in prostate cancer cells.
Prostatic Neoplasms
Targeting and killing of prostate cancer cells using lentiviral constructs containing a sequence recognized by translation factor eIF4E and a prostate-specific promoter.
Prostatic Neoplasms
Targeting of protein translation as a new treatment paradigm for prostate cancer.
Prostatic Neoplasms
The mechanism of growth-inhibitory effect of DOC-2/DAB2 in prostate cancer. Characterization of a novel GTPase-activating protein associated with N-terminal domain of DOC-2/DAB2.
Prostatic Neoplasms
Tumor suppression by PTEN requires the activation of the PKR-eIF2alpha phosphorylation pathway.
Prostatic Neoplasms
Two genome-wide association studies of aggressive prostate cancer implicate putative prostate tumor suppressor gene DAB2IP.
Protein Deficiency
Cdc42 GTPase-activating protein deficiency promotes genomic instability and premature aging-like phenotypes.
protein-synthesizing gtpase deficiency
Cdc42 GTPase-activating protein deficiency promotes genomic instability and premature aging-like phenotypes.
protein-synthesizing gtpase deficiency
Identification of a Missense Variant in the EIF2B3 Gene Causing Vanishing White Matter Disease with Antenatal-Onset but Mild Symptoms and Long-Term Survival.
Proteostasis Deficiencies
PPP1R15A-mediated dephosphorylation of eIF2? is unaffected by Sephin1 or Guanabenz.
Pseudorabies
The IE180 protein of pseudorabies virus suppresses phosphorylation of translation initiation factor eIF2?.
Pterygium
Correlation of pterygium severity with IQ-domain GTPase-activating protein 1 (IQGAP1) and mast cells.
Pulmonary Arterial Hypertension
Clinical characteristics and survival of Chinese patients diagnosed with pulmonary arterial hypertension who carry BMPR2 or EIF2KAK4 variants.
Pulmonary Disease, Chronic Obstructive
Muscle atrophy and hypertrophy signaling in patients with chronic obstructive pulmonary disease.
Pulmonary Disease, Chronic Obstructive
Organelle-specific autophagy in inflammatory diseases: a potential therapeutic target underlying the quality control of multiple organelles.
Pulmonary Fibrosis
Fluorofenidone attenuates bleomycin-induced pulmonary fibrosis by inhibiting eukaryotic translation initiation factor 3a (eIF3a) in rats.
Pulmonary Fibrosis
Knockdown of eIF3a attenuates the pro-fibrogenic response of hepatic stellate cells induced by TGF-?1.
Pulmonary Fibrosis
Knockdown of elF3a inhibits collagen synthesis in renal fibroblasts via Inhibition of transforming growth factor-?1/Smad signaling pathway.
Pulmonary Fibrosis
Resetting proteostasis with ISRIB promotes epithelial differentiation to attenuate pulmonary fibrosis.
Pulmonary Fibrosis
Role of eukaryotic translation initiation factor 3a in bleomycin-induced pulmonary fibrosis.
Pulmonary Fibrosis
[Effects of calcitonin gene-related peptide on eIF3a and p27 expression in bleomycin-induced pulmonary fibrosis of rats].
Pulmonary Veno-Occlusive Disease
Pulmonary vascular remodeling patterns and expression of general control nonderepressible 2 (GCN2) in pulmonary veno-occlusive disease.
Pulmonary Veno-Occlusive Disease
Pulmonary veno-occlusive disease and pulmonary capillary hemangiomatosis.
Pulmonary Veno-Occlusive Disease
Unique wreath-like smooth muscle proliferation of the pulmonary vasculature in pulmonary veno-occlusive disease versus pulmonary arterial hypertension.
Rabies
Interscience conference on antimicrobial agents and chemotherapy - 50th annual meeting - research on promising new agents: part 1.
receptor protein-tyrosine kinase deficiency
Insulin-like growth factor I receptor signaling is required for exercise-induced cardiac hypertrophy.
Retinitis Pigmentosa
Membrane protein transport in photoreceptors: the function of PDE?: the Proctor lecture.
Retinitis Pigmentosa
The retinitis pigmentosa 2 gene product is a GTPase-activating protein for Arf-like 3.
Retinoblastoma
Analysis of peripheral blood mononuclear cells gene expression in endurance horses by cDNA-AFLP technique.
Retinoblastoma
Elevated levels of cyclin D1 protein in response to increased expression of eukaryotic initiation factor 4E.
Retinoblastoma
Function of human cytomegalovirus UL97 kinase in viral infection and its inhibition by maribavir.
Retinoblastoma
Microarray analysis of perichondral and reserve growth plate zones identifies differential gene expressions and signal pathways.
Retinoblastoma
Targeting eIF4E inhibits growth, survival and angiogenesis in retinoblastoma and enhances efficacy of chemotherapy.
Rhabdomyosarcoma
The transcription elongation factor TCEA3 induces apoptosis in rhabdomyosarcoma.
Rickettsia Infections
Immunoproteomic profiling of Rickettsia parkeri and Rickettsia amblyommii.
Rift Valley Fever
Rift Valley fever virus NSs protein promotes post-transcriptional downregulation of protein kinase PKR and inhibits eIF2alpha phosphorylation.
Rotavirus Infections
Protein kinase R is responsible for the phosphorylation of eIF2alpha in rotavirus infection.
Rotavirus Infections
Rotavirus infection induces the phosphorylation of eIF2alpha but prevents the formation of stress granules.
Rotavirus Infections
The Eukaryotic Translation Initiation Factor 4F Complex Restricts Rotavirus Infection via Regulating the Expression of IRF1 and IRF7.
Salmonella Infections
Elongation factor P controls translation of the mgtA gene encoding a Mg2+ transporter during Salmonella infection.
Salmonella Infections
tRNA(Pro) -mediated downregulation of elongation factor P is required for mgtCBR expression during Salmonella infection.
Sarcoma
Efficient adenovirus vector-mediated PPAR gamma gene transfer into mouse embryoid bodies promotes adipocyte differentiation.
Sarcoma, Avian
Cytolytic activity induced by intramuscular injection of plasmid DNA expressing the nucleocapsid protein of the JHM strain of mouse hepatitis virus into C57BL/6 mice.
Sarcoma, Avian
Efficient gene transfer into mouse embryonic stem cells with adenovirus vectors.
Sarcoma, Avian
Evaluation of promoter strength in mouse and rat primary hepatocytes using adenovirus vectors.
Sarcoma, Avian
Inducible high-level expression vector for mammalian cells, pEF-LAC carrying human elongation factor 1alpha promoter and lac operator.
Sarcoma, Avian
Initiation factor eIF2B not p70 S6 kinase is involved in the activation of the PI-3K signalling pathway induced by the v-src oncogene.
Sarcoma, Avian
Promoter effects of adeno-associated viral vector for transgene expression in the cochlea in vivo.
Sarcoma, Avian
Seminiferous tubule cannulation (STC): a new, sensitive technique for detecting gene transfer in developing sperm.
Sarcoma, Avian
Stable expression of hrGFP by mouse embryonic stem cells: promoter activity in the undifferentiated state and during dopaminergic neural differentiation.
Sarcoma, Avian
Vargula hilgendorfii luciferase: a secreted reporter enzyme for monitoring gene expression in mammalian cells.
Scleroderma, Systemic
Identification of new autoantigens for primary biliary cirrhosis using human proteome microarrays.
Seizures
Deletion of Long Isoform of Eukaryotic Elongation Factor 1B? Leads to Audiogenic Seizures and Aversive Stimulus-Induced Long-Lasting Activity Suppression in Mice.
Seizures
Identification of a Missense Variant in the EIF2B3 Gene Causing Vanishing White Matter Disease with Antenatal-Onset but Mild Symptoms and Long-Term Survival.
Seizures, Febrile
Carbon monoxide offers neuroprotection from hippocampal cell damage induced by recurrent febrile seizures through the PERK-activated ER stress pathway.
Seminoma
Eukaryotic initiation factor 3 p110 mRNA is overexpressed in testicular seminomas.
Seminoma
The human Y-encoded testis-specific protein interacts functionally with eukaryotic translation elongation factor eEF1A, a putative oncoprotein.
Sepsis
Ectopic expression of eIF2Bepsilon in rat skeletal muscle rescues the sepsis-induced reduction in guanine nucleotide exchange activity and protein synthesis.
Sepsis
Eukaryotic Translation Initiation Factor 5A Small Interference RNA-Liposome Complexes Reduce Inflammation and Increase Survival in Murine Models of Severe Sepsis and Acute Lung Injury.
Sepsis
Phosphorylation of eukaryotic initiation factor eIF2Bepsilon in skeletal muscle during sepsis.
Sepsis
Sepsis-induced suppression of skeletal muscle translation initiation mediated by tumor necrosis factor alpha.
Sepsis
TNF-binding protein ameliorates inhibition of skeletal muscle protein synthesis during sepsis.
Severe Acute Respiratory Syndrome
Severe acute respiratory syndrome coronavirus triggers apoptosis via protein kinase R but is resistant to its antiviral activity.
Severe Acute Respiratory Syndrome
The nucleocapsid protein of severe acute respiratory syndrome coronavirus inhibits cell cytokinesis and proliferation by interacting with translation elongation factor 1alpha.
Shwachman-Diamond Syndrome
Cooperative energetic effects elicited by the yeast Shwachman-Diamond syndrome protein (Sdo1) and guanine nucleotides modulate the complex conformational landscape of the elongation factor-like 1 (Efl1) GTPase.
Shwachman-Diamond Syndrome
Defective Guanine Nucleotide Exchange in the Elongation Factor-like 1 (EFL1) GTPase by Mutations in the Shwachman-Diamond Syndrome Protein.
Shwachman-Diamond Syndrome
Direct interaction between EFL1 and SBDS is mediated by an intrinsically disordered insertion domain.
Shwachman-Diamond Syndrome
Exploring the role of elongation Factor-Like 1 (EFL1) in Shwachman-Diamond syndrome through molecular dynamics.
Shwachman-Diamond Syndrome
Fluorescence Anisotropy as a Tool to Study Protein-protein Interactions.
Shwachman-Diamond Syndrome
Interaction of the GTPase Elongation Factor Like-1 with the Shwachman-Diamond Syndrome Protein and Its Missense Mutations.
Sleep Deprivation
Aging induced endoplasmic reticulum stress alters sleep and sleep homeostasis.
Spasms, Infantile
West syndrome caused by homozygous variant in the evolutionary conserved gene encoding the mitochondrial elongation factor GUF1.
sphingosine kinase deficiency
SPHK1 deficiency protects mice from acetaminophen-induced ER stress and mitochondrial permeability transition.
Spinal Cord Ischemia
Transient ischemia induces massive nuclear accumulation of SUMO2/3-conjugated proteins in spinal cord neurons.
Spinal Dysraphism
Allergenic and antigenic determinants of latex allergen Hev b 1: peptide mapping of epitopes recognized by human, murine and rabbit antibodies.
Spinal Dysraphism
IgE antibodies to prohevein, hevein, and rubber elongation factor in children with latex allergy.
Spinal Dysraphism
Latex antigens: identification and use in clinical and experimental studies, including crossreactivity with food and pollen allergens.
Spinal Dysraphism
The 14.6 kd rubber elongation factor (Hev b 1) and 24 kd (Hev b 3) rubber particle proteins are recognized by IgE from patients with spina bifida and latex allergy.
Squamous Cell Carcinoma of Head and Neck
Eukaryotic translation elongation factor 1?, N-terminal propeptide of type I collagen and cancer-associated fibroblasts are prognostic markers of oral squamous cell carcinoma patients.
Squamous Cell Carcinoma of Head and Neck
Eukaryotic translation initiation factor 5A-2 involves in doxorubicin-induced epithelial-mesenchymal transition in oral squamous cell carcinoma cells.
Squamous Cell Carcinoma of Head and Neck
Farnesyltransferase inhibitor SCH66336 induces rapid phosphorylation of eukaryotic translation elongation factor 2 in head and neck squamous cell carcinoma cells.
Squamous Cell Carcinoma of Head and Neck
Growth inhibition of head and neck squamous carcinoma cells by small interfering RNAs targeting eIF4E or cyclin D1 alone or combined with cisplatin.
Squamous Cell Carcinoma of Head and Neck
Loss of DLC1 is an independent prognostic factor in patients with oral squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
MicroRNA-216a inhibits the growth and metastasis of oral squamous cell carcinoma by targeting eukaryotic translation initiation factor 4B.
Squamous Cell Carcinoma of Head and Neck
N6-methyladenosine demethyltransferase FTO-mediated autophagy in malignant development of oral squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
Understanding and Targeting the Eukaryotic Translation Initiation Factor eIF4E in Head and Neck Cancer.
Squamous Cell Carcinoma of Head and Neck
[Correlation between prognosis and the expression of eukaryotic translation initiation factor 4E in surgical margin specimen of laryngeal squamous cell carcinoma]
Staphylococcal Infections
Fusidic Acid: A Bacterial Elongation Factor Inhibitor for the Oral Treatment of Acute and Chronic Staphylococcal Infections.
Starvation
A critical role of eEF-2K in mediating autophagy in response to multiple cellular stresses.
Starvation
A network of hydrophobic residues impeding helix alphaC rotation maintains latency of kinase Gcn2, which phosphorylates the alpha subunit of translation initiation factor 2.
Starvation
A novel mechanism for the control of translation initiation by amino acids, mediated by phosphorylation of eukaryotic initiation factor 2B.
Starvation
ALS-FTLD-linked mutations of SQSTM1/p62 disrupt selective autophagy and NFE2L2/NRF2 anti-oxidative stress pathway.
Starvation
Amino acid starvation induces the SNAT2 neutral amino acid transporter by a mechanism that involves eukaryotic initiation factor 2alpha phosphorylation and cap-independent translation.
Starvation
An integrated stress response regulates amino acid metabolism and resistance to oxidative stress.
Starvation
Arabidopsis eIF2alpha kinase GCN2 is essential for growth in stress conditions and is activated by wounding.
Starvation
Asp56 in actin is critical for the full activity of the amino acid starvation-responsive kinase Gcn2.
Starvation
Characterization of a mammalian homolog of the GCN2 eukaryotic initiation factor 2alpha kinase.
Starvation
Characterization of the initiation factor eIF2B and its regulation in Drosophila melanogaster.
Starvation
Coordinate regulation of eIF2? phosphorylation by dPPP1R15 and dGCN2 is required during development.
Starvation
Differential proteome and cellular adhesion analyses of the probiotic bacterium Lactobacillus acidophilus NCFM grown on raffinose - an emerging prebiotic.
Starvation
Domain II of the translation elongation factor eEF1A is required for Gcn2 kinase inhibition.
Starvation
eIF2 independently binds two distinct eIF2B subcomplexes that catalyze and regulate guanine-nucleotide exchange.
Starvation
eIF2? is critical for eIF5-mediated GDP-dissociation inhibitor activity and translational control.
Starvation
Elongation factor Tu.guanosine 3'-diphosphate 5'-diphosphate complex increases the fidelity of proofreading in protein biosynthesis: mechanism for reducing translational errors introduced by amino acid starvation.
Starvation
Evaluation of reference genes for real-time quantitative PCR analysis in southern corn rootworm, Diabrotica undecimpunctata howardi (Barber).
Starvation
Filament formation by the translation factor eIF2B regulates protein synthesis in starved cells.
Starvation
Gcn1 contacts the small ribosomal protein Rps10, which is required for full activation of the protein kinase Gcn2.
Starvation
Gcn2 mediates Gcn4 activation in response to glucose stimulation or UV radiation not via GCN4 translation.
Starvation
Histidyl-tRNA synthetase-related sequences in GCN2 protein kinase regulate in vitro phosphorylation of eIF-2.
Starvation
IfkA, a presumptive eIF2 alpha kinase of Dictyostelium, is required for proper timing of aggregation and regulation of mound size.
Starvation
IMPACT, a protein preferentially expressed in the mouse brain, binds GCN1 and inhibits GCN2 activation.
Starvation
Inhibition of eEF2K synergizes with glutaminase inhibitors or 4EBP1 depletion to suppress growth of triple-negative breast cancer cells.
Starvation
Inhibition of translation initiation by volatile anesthetics involves nutrient-sensitive GCN-independent and -dependent processes in yeast.
Starvation
L-arginine availability regulates inducible nitric oxide synthase-dependent host defense against Helicobacter pylori.
Starvation
Life span extension via eIF4G inhibition is mediated by posttranscriptional remodeling of stress response gene expression in C. elegans.
Starvation
Loss of translational control in yeast compromised for the major mRNA decay pathway.
Starvation
Mucin- and carbohydrate-stimulated adhesion and subproteome changes of the probiotic bacterium Lactobacillus acidophilus NCFM.
Starvation
Overexpression of eukaryotic translation Elongation Factor 3 (eEF3) impairs GCN2 activation.
Starvation
PfeIK1, a eukaryotic initiation factor 2alpha kinase of the human malaria parasite Plasmodium falciparum, regulates stress-response to amino-acid starvation.
Starvation
Phosphorylation decelerates conformational dynamics in bacterial translation elongation factors.
Starvation
Polyribosome binding by GCN1 is required for full activation of eukaryotic translation initiation factor 2{alpha} kinase GCN2 during amino acid starvation.
Starvation
Rapamycin-induced translational derepression of GCN4 mRNA involves a novel mechanism for activation of the eIF2 alpha kinase GCN2.
Starvation
Receptor for activated C-kinase (RACK1) homolog Cpc2 facilitates the general amino acid control response through Gcn2 kinase in fission yeast.
Starvation
Reducing translation through eIF4G/IFG-1 improves survival under ER stress that depends on heat shock factor HSF-1 in Caenorhabditis elegans.
Starvation
Regulation of internal ribosomal entry site-mediated translation by phosphorylation of the translation initiation factor eIF2alpha.
Starvation
Regulation of internal ribosome entry site-mediated translation by eukaryotic initiation factor-2alpha phosphorylation and translation of a small upstream open reading frame.
Starvation
Repression of GCN4 mRNA translation by nitrogen starvation in Saccharomyces cerevisiae.
Starvation
Ribosome binding protein GCN1 regulates the cell cycle and cell proliferation and is essential for the embryonic development of mice.
Starvation
Snf1 promotes eIF2{alpha} phosphorylation by activating Gcn2 and inhibiting phosphatases Glc7 and Sit4.
Starvation
Surgical stress resistance induced by single amino acid deprivation requires Gcn2 in mice.
Starvation
The eIF-2 alpha kinases: regulators of protein synthesis in starvation and stress.
Starvation
The eIF2 kinase GCN2 is essential for the murine immune system to adapt to amino acid deprivation by asparaginase.
Starvation
The histidyl-tRNA synthetase-related sequence in the eIF-2 alpha protein kinase GCN2 interacts with tRNA and is required for activation in response to starvation for different amino acids.
Starvation
The Interaction between the Ribosomal Stalk Proteins and Translation Initiation Factor 5B Promotes Translation Initiation.
Starvation
The ribosomal P-stalk couples amino acid starvation to GCN2 activation in mammalian cells.
Starvation
The role of nitric-oxide synthase in the regulation of UVB light-induced phosphorylation of the alpha subunit of eukaryotic initiation factor 2.
Starvation
The structure of human GCN2 reveals a parallel, back-to-back kinase dimer with a plastic DFG activation loop motif.
Starvation
Translation mediated by the internal ribosome entry site of the cat-1 mRNA is regulated by glucose availability in a PERK kinase-dependent manner.
Starvation
Translation of the yeast transcriptional activator GCN4 is stimulated by purine limitation: implications for activation of the protein kinase GCN2.
Starvation
Translation reprogramming is an evolutionarily conserved driver of phenotypic plasticity and therapeutic resistance in melanoma.
Starvation
Translational control by TOR and TAP42 through dephosphorylation of eIF2alpha kinase GCN2.
Starvation
Translational control of GCN4: an in vivo barometer of initiation-factor activity.
Starvation
Translational repression of inducible NO synthase in macrophages by l-arginine depletion is not associated with an increased phosphorylation of eIF2alpha.
Starvation
Upregulation of eIF5B controls cell-cycle arrest and specific developmental stages.
Status Epilepticus
Phosphorylation of the alpha subunit of translation initiation factor-2 by PKR mediates protein synthesis inhibition in the mouse brain during status epilepticus.
Status Epilepticus
Phosphorylation of translation initiation factor eIF2alpha in the brain during pilocarpine-induced status epilepticus in mice.
Stomach Neoplasms
Activated Integrated Stress Response Induced by Salubrinal Promotes Cisplatin Resistance in Human Gastric Cancer Cells via Enhanced xCT Expression and Glutathione Biosynthesis.
Stomach Neoplasms
Clinical Significance of CLDN18.2 Expression in Metastatic Diffuse-Type Gastric Cancer.
Stomach Neoplasms
Corosolic acid enhances 5-fluorouracil-induced apoptosis against SNU-620 human gastric carcinoma cells by inhibition of mammalian target of rapamycin.
Stomach Neoplasms
Downregulation of eukaryotic translation initiation factor 3b inhibited proliferation and metastasis of gastric cancer.
Stomach Neoplasms
Expression of Elongation Factor (EF)-Tu Is Correlated with Prognosis of Gastric Adenocarcinomas.
Stomach Neoplasms
Expression of eukaryotic translation initiation factor 5A-2 (eIF5A-2) associated with poor survival in gastric cancer.
Stomach Neoplasms
Impact of a Eukaryotic Translation Initiation Factor 3a Polymorphism on Susceptibility to Gastric Cancer.
Stomach Neoplasms
Inhibition of mTOR signaling potentiates the effects of trichostatin A in human gastric cancer cell lines by promoting histone acetylation.
Stomach Neoplasms
Overexpression of eukaryotic elongation factor 1 alpha-2 is associated with poorer prognosis in patients with gastric cancer.
Stomach Neoplasms
Overexpression of eukaryotic translation initiation factor 5A2 (EIF5A2) correlates with cell aggressiveness and poor survival in gastric cancer.
Stomach Neoplasms
Overexpression of the Transmembrane Protein IQGAP3 Is Associated with Poor Survival of Patients with Gastric Cancer.
Stomach Neoplasms
P21 activated kinase 4 binds translation elongation factor eEF1A1 to promote gastric cancer cell migration and invasion.
Stomach Neoplasms
RhoC regulates the proliferation of gastric cancer cells through interaction with IQGAP1.
Stomach Neoplasms
Thermo-chemotherapy inhibits the proliferation and metastasis of gastric cancer cells via suppression of EIF5A2 expression.
Stomach Neoplasms
Translation elongation factor eEF1B? is identified as a novel prognostic marker of gastric cancer.
Stomach Neoplasms
[Effects of eukaryotic translation initiation factor 5A2 down-regulation by small interfering RNA on aggressiveness of MKN28 human].
Stomach Neoplasms
[Expression of elongation factor 1 gamma-related sequence in human gastric cancer: preliminary report]
Supranuclear Palsy, Progressive
Genetic influences on cognition in progressive supranuclear palsy.
Tauopathies
Tauopathy-associated PERK alleles are functional hypomorphs that increase neuronal vulnerability to ER stress.
Teratozoospermia
Identification of candidate causal genes and their associated pathogenic mechanisms underlying teratozoospermia based on the spermatozoa transcript profiles.
Thymoma
4EBP1/eIF4E and p70S6K/RPS6 axes play critical and distinct roles in hepatocarcinogenesis driven by AKT and N-Ras proto-oncogenes in mice.
Thymoma
Autophagy controls neonatal myogenesis by regulating the GH-IGF1 system through a NFE2L2- and DDIT3-mediated mechanism.
Thymoma
Cell quality control mechanisms maintain stemness and differentiation potential of P19 embryonic carcinoma cells.
Thymoma
Heat induces myogenic transcription factors of myoblast cells via transient receptor potential vanilloid 1 (Trpv1).
Thymoma
Transcriptomic differences of genes in the avian target of rapamycin (avTOR) pathway in a divergent line of meat-type chickens selected for feed efficiency.
Thyroid Cancer, Papillary
Clinical significance of eukaryotic translation initiation factor 5A2 in papillary thyroid cancer.
Thyroid Cancer, Papillary
Next-generation sequencing identified somatic alterations that may underlie the etiology of Chinese papillary thyroid carcinoma.
Thyroid Cancer, Papillary
Nuclear morphometry and texture analysis on cytological smears of thyroid neoplasms: a study of 50 cases.
Thyroid Neoplasms
Antiviral Drug Ribavirin Targets Thyroid Cancer Cells by Inhibiting the eIF4E-?-Catenin Axis.
Thyroid Neoplasms
Downregulation of IQGAP1 inhibits epithelial-mesenchymal transition via the HIF1?/VEGF-A signaling pathway in gastric cancer.
Thyroid Neoplasms
EBP1 suppresses growth, migration, and invasion of thyroid cancer cells through upregulating RASAL expression.
Thyroid Neoplasms
Effects of small interfering RNA-mediated silencing of susceptibility genes of non-syndromic cleft lip with or without cleft palate on cell proliferation and migration.
Thyroid Neoplasms
Inhibition of MNK pathways enhances cancer cell response to chemotherapy with temozolomide and targeted radionuclide therapy.
Tick Infestations
Control of tick infestations in cattle vaccinated with bacterial membranes containing surface-exposed tick protective antigens.
Tinea
Assessment of a pan-dermatophyte nested-PCR compared with conventional methods for direct detection and identification of dermatophytosis agents in animals.
Tinea
Multilocus differentiation of the related dermatophytes Microsporum canis, Microsporum ferrugineum and Microsporum audouinii.
Toxoplasmosis
Protective immunity against acute toxoplasmosis in BALB/c mice induced by a DNA vaccine encoding Toxoplasma gondii elongation factor 1-alpha.
Toxoplasmosis
Toxoplasma gondii Elongation Factor 1-Alpha (TgEF-1?) Is a Novel Vaccine Candidate Antigen against Toxoplasmosis.
Triple Negative Breast Neoplasms
Identification of Cardiac Glycosides as Novel Inhibitors of eIF4A1-Mediated Translation in Triple-Negative Breast Cancer Cells.
Triple Negative Breast Neoplasms
Puncta intended: connecting the dots between autophagy and cell stress networks.
Triple Negative Breast Neoplasms
Therapeutic targeting of transcriptional cyclin-dependent kinases.
Trypanosomiasis, African
Novel membrane-bound eIF2alpha kinase in the flagellar pocket of Trypanosoma brucei.
Tuberculosis
Antibodies against mycobacterial antigens in the synovial fluid of patients with temporomandibular disorders.
Tuberculosis
BAG2 ameliorates endoplasmic reticulum stress-induced cell apoptosis in Mycobacterium tuberculosis-infected macrophages through selective autophagy.
Tuberculosis
Biophysical characterization and ligand-binding properties of the elongation factor Tu from Mycobacterium tuberculosis.
Tuberculosis
Characterization of Mycobacterium tuberculosis ribosome recycling factor (RRF) and a mutant lacking six amino acids from the C-terminal end reveals that the C-terminal residues are important for its occupancy on the ribosome.
Tuberculosis
Developing synergistic drug combinations to restore antibiotic sensitivity in drug-resistant Mycobacterium tuberculosis.
Tuberculosis
Interaction of Mycobacterium tuberculosis Elongation Factor Tu with GTP is regulated by phosphorylation.
Tuberculosis
M. tuberculosis PknG manipulates host autophagy flux to promote pathogen intracellular survival.
Tuberculosis
Mapping and identification of the major cell wall-associated components of Mycobacterium leprae.
Tuberculosis
Monoclonal antibodies specific for elongation factor Tu and complete nucleotide sequence of the tuf gene in Mycobacterium tuberculosis.
Tuberculosis
Nucleoside diphosphate kinase of Mycobacterium tuberculosis acts as GTPase-activating protein for Rho-GTPases.
Tuberculosis
Specific interaction between the ribosome recycling factor and the elongation factor G from Mycobacterium tuberculosis mediates peptidyl-tRNA release and ribosome recycling in Escherichia coli.
Tuberculosis
Structure of translation initiation factor 1 from Mycobacterium tuberculosis and inferred binding to the 30S ribosomal subunit.
Tuberous Sclerosis
A role of the mammalian target of rapamycin (mTOR) in glutamate-induced down-regulation of tuberous sclerosis complex proteins 2 (TSC2).
Tuberous Sclerosis
Activation of AMP-activated protein kinase by 5-aminoimidazole-4-carboxamide-1-beta-D-ribonucleoside prevents leucine-stimulated protein synthesis in rat skeletal muscle.
Tuberous Sclerosis
AMP-activated protein kinase signalling pathways are down regulated and skeletal muscle development impaired in fetuses of obese, over-nourished sheep.
Tuberous Sclerosis
Anthocyanins are novel AMPK?1 stimulators that suppress tumor growth by inhibiting mTOR phosphorylation.
Tuberous Sclerosis
Dysregulation of Elongation Factor 1A Expression is Correlated with Synaptic Plasticity Impairments in Alzheimer's Disease.
Tuberous Sclerosis
Effect of Sishen Pill on Memory T Cells From Experimental Colitis Induced by Dextran Sulfate Sodium.
Tuberous Sclerosis
Farnesylthiosalicylic acid (salirasib) inhibits Rheb in TSC2-null ELT3 cells: A potential treatment for lymphangioleiomyomatosis.
Tuberous Sclerosis
Glucose stimulates protein synthesis in skeletal muscle of neonatal pigs through an AMPK- and mTOR-independent process.
Tuberous Sclerosis
Immunohistochemical Analysis of mTOR Pathway-Related Proteins in Kaposiform Hemangioendothelioma.
Tuberous Sclerosis
Leucine acts as a nutrient signal to stimulate protein synthesis in neonatal pigs.
Tuberous Sclerosis
MTORC1 coordinates the autophagy and apoptosis signaling in articular chondrocytes in osteoarthritic temporomandibular joint.
Tuberous Sclerosis
Novel role of the small GTPase Rheb: its implication in endocytic pathway independent of the activation of mammalian target of rapamycin.
Tuberous Sclerosis
Proteomes analysis reveals the involvement of autophagy in AD-like neuropathology induced by noise exposure and ApoE4.
Tuberous Sclerosis
Significance of dynamic changes in gastric smooth muscle cell apoptosis, PI3K-AKT-mTOR and AMPK-mTOR signaling in a rat model of diabetic gastroparesis.
Tuberous Sclerosis
Stimulation of muscle protein synthesis by prolonged parenteral infusion of leucine is dependent on amino acid availability in neonatal pigs.
Tuberous Sclerosis
Structural basis for the unique biological function of small GTPase RHEB.
Tuberous Sclerosis
The mTORC1 effectors S6K1 and 4E-BP play different roles in CNS axon regeneration.
Tuberous Sclerosis
The RHEB-mTOR axis regulates expression of Tf2 transposons in fission yeast.
Tuberous Sclerosis
Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb.
Urinary Bladder Neoplasms
Downregulation of Ral GTPase-activating protein promotes tumor invasion and metastasis of bladder cancer.
Urinary Bladder Neoplasms
Identification and validation of AIB1 and EIF5A2 for noninvasive detection of bladder cancer in urine samples.
Urinary Bladder Neoplasms
mRNA translation is a therapeutic vulnerability necessary for bladder epithelial transformation.
Urinary Bladder Neoplasms
N1-guanyl-1,7-diaminoheptane sensitizes bladder cancer cells to doxorubicin by preventing epithelial-mesenchymal transition through inhibition of eukaryotic translation initiation factor 5A2 activation.
Urinary Bladder Neoplasms
Proteomics analysis of bladder cancer invasion: Targeting EIF3D for therapeutic intervention.
Urinary Bladder Neoplasms
RASAL2, a RAS GTPase-activating protein, inhibits stemness and epithelial-mesenchymal transition via MAPK/SOX2 pathway in bladder cancer.
Urinary Bladder Neoplasms
Re: Downregulation of Ral GTPase-Activating Protein Promotes Tumor Invasion and Metastasis of Bladder Cancer.
Usher Syndromes
Elongation factor 1 alpha1 and genes associated with Usher syndromes are downstream targets of GBX2.
Uterine Cervical Neoplasms
Eukaryotic translation initiation factor 3B is overexpressed and correlates with higher FIGO stage III/IV, lymph node metastasis and unfavorable survival profiles in cervical cancer patients.
Uterine Cervical Neoplasms
Eukaryotic translation initiator protein 1A isoform, CCS-3, enhances the transcriptional repression of p21CIP1 by proto-oncogene FBI-1 (Pokemon/ZBTB7A).
Uterine Cervical Neoplasms
HPV18 E7 induces the over-transcription of eIF4E gene in cervical cancer.
Uterine Cervical Neoplasms
Inhibiting MNK Selectively Targets Cervical Cancer via Suppressing eIF4E-Mediated ?-Catenin Activation.
Uterine Cervical Neoplasms
Inhibition of eukaryotic translation initiation factor 4E is effective against chemo-resistance in colon and cervical cancer.
Uterine Cervical Neoplasms
Targeting the eIF4E/?-catenin axis sensitizes cervical carcinoma squamous cells to chemotherapy.
Vaccinia
A targeted approach to identification of vaccinia virus postreplicative transcription elongation factors: genetic evidence for a role of the H5R gene in vaccinia transcription.
Vaccinia
Binding and nuclear relocalization of protein kinase R by human cytomegalovirus TRS1.
Vaccinia
Characterization of the interactions among vaccinia virus transcription factors G2R, A18R, and H5R.
Vaccinia
Expression of vaccinia virus K3L protein in yeast inhibits eukaryotic initiation factor-2 kinase GCN2 and the general amino acid control pathway.
Vaccinia
Homologous regions of the alpha subunit of eukaryotic translational initiation factor 2 (eIF2alpha) and the vaccinia virus K3L gene product interact with the same domain within the dsRNA-activated protein kinase (PKR).
Vaccinia
Human interferon-gamma mRNA autoregulates its translation through a pseudoknot that activates the interferon-inducible protein kinase PKR.
Vaccinia
Identification of a group of cellular cofactors that stimulate the binding of RNA polymerase II and TRP-185 to human immunodeficiency virus 1 TAR RNA.
Vaccinia
Identification of rpo30, a vaccinia virus RNA polymerase gene with structural similarity to a eucaryotic transcription elongation factor.
Vaccinia
In vivo regulation of protein synthesis by phosphorylation of the alpha subunit of wheat eukaryotic initiation factor 2.
Vaccinia
Interaction between the J3R subunit of vaccinia virus poly(A) polymerase and the H4L subunit of the viral RNA polymerase.
Vaccinia
Orthopoxvirus K3 orthologs show virus- and host-specific inhibition of the antiviral protein kinase PKR.
Vaccinia
Phenotypic characterization of mutants in vaccinia virus gene G2R, a putative transcription elongation factor.
Vaccinia
Pseudosubstrate inhibition of protein kinase PKR by swine pox virus C8L gene product.
Vaccinia
Purification and identification of a vaccinia virus-encoded intermediate stage promoter-specific transcription factor that has homology to eukaryotic transcription factor SII (TFIIS) and an additional role as a viral RNA polymerase subunit.
Vaccinia
Recombinant vaccinia virus K3L gene product prevents activation of double-stranded RNA-dependent, initiation factor 2 alpha-specific protein kinase.
Vaccinia
Recruitment of host translation initiation factor eIF4G by the Vaccinia Virus ssDNA-binding protein I3.
Vaccinia
Regulation of the protein kinase PKR by the vaccinia virus pseudosubstrate inhibitor K3L is dependent on residues conserved between the K3L protein and the PKR substrate eIF2alpha.
Vaccinia
The E3L and K3L vaccinia virus gene products stimulate translation through inhibition of the double-stranded RNA-dependent protein kinase by different mechanisms.
Vaccinia
The effect of the vaccinia K1 protein on the PKR-eIF2alpha pathway in RK13 and HeLa cells.
Vaccinia
The eukaryotic translation initiation factor 4E is not modified during the course of vaccinia virus replication.
Vaccinia
The positive transcription elongation factor activity of the vaccinia virus J3 protein is independent from its (nucleoside-2'-O-) methyltransferase and poly(A) polymerase stimulatory functions.
Vaccinia
The vaccinia virus A18R DNA helicase is a postreplicative negative transcription elongation factor.
Vaccinia
The vaccinia virus bifunctional gene J3 (nucleoside-2'-O-)-methyltransferase and poly(A) polymerase stimulatory factor is implicated as a positive transcription elongation factor by two genetic approaches.
Vaccinia
The vaccinia virus K3L gene product potentiates translation by inhibiting double-stranded-RNA-activated protein kinase and phosphorylation of the alpha subunit of eukaryotic initiation factor 2.
Vaccinia
Transcription elongation activity of the vaccinia virus J3 protein in vivo is independent of poly(A) polymerase stimulation.
Vaccinia
Translation control by protein kinase R restricts minute virus of mice infection: role in parvovirus oncolysis.
Vaccinia
Vaccinia virus K1L protein mediates host-range function in RK-13 cells via ankyrin repeat and may interact with a cellular GTPase-activating protein.
Vaccinia
Vaccinia virus protein synthesis has a low requirement for the intact translation initiation factor eIF4F, the cap-binding complex, within infected cells.
Vaccinia
Vaccinia virus-mediated inhibition of host protein synthesis involves neither degradation nor underphosphorylation of components of the cap-binding eukaryotic translation initiation factor complex eIF-4F.
Vaccinia
Viral host range factors C7 or K1 are essential for modified vaccinia virus Ankara late gene expression in human and murine cells, irrespective of their capacity to inhibit PKR-mediated eIF2{alpha} phosphorylation.
Varicose Veins
IQGAP1 promotes the phenotypic switch of vascular smooth muscle by myocardin pathway: a potential target for varicose vein.
Vascular System Injuries
The Ran GTPase-activating protein (RanGAP1) is critically involved in smooth muscle cell differentiation, proliferation and migration following vascular injury: implications for neointima formation and restenosis.
Vesicular Stomatitis
Ciliary beating recovery in deficient human airway epithelial cells after lentivirus ex vivo gene therapy.
Vesicular Stomatitis
High-level sustained transgene expression in human embryonic stem cells using lentiviral vectors.
Vesicular Stomatitis
Human papillomaviruses target the double-stranded RNA protein kinase pathway.
Vesicular Stomatitis
Lentiviral Transfection of Ependymal Primary Cultures Facilitates the Characterisation of Kinocilia-specific Promoters.
Vesicular Stomatitis
Regulation of protein synthesis in vesicular stomatitis virus-infected mouse L-929 cells by decreased protein synthesis initiation factor 2 activity.
Vesicular Stomatitis
Resistance to vesicular stomatitis virus infection requires a functional cross talk between the eukaryotic translation initiation factor 2alpha kinases PERK and PKR.
Vesicular Stomatitis
Retinal cell type expression specificity of HIV-1-derived gene transfer vectors upon subretinal injection in the adult rat: influence of pseudotyping and promoter.
Vesicular Stomatitis
The eIF2alpha kinases inhibit vesicular stomatitis virus replication independently of eIF2alpha phosphorylation.
Virus Diseases
A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress.
Virus Diseases
Activation of double-stranded RNA-activated protein kinase by mild impairment of oxidative metabolism in neurons.
Virus Diseases
An antiviral response directed by PKR phosphorylation of the RNA helicase A.
Virus Diseases
An Isoform of Eukaryotic Initiation Factor 4E from Chrysanthemum morifolium Interacts with Chrysanthemum Virus B Coat Protein.
Virus Diseases
Binding between elongation factor 1A and the 3'-UTR of Chinese wheat mosaic virus is crucial for virus infection.
Virus Diseases
Cell death/proliferation roles for nc886, a non-coding RNA, in the protein kinase R pathway in cholangiocarcinoma.
Virus Diseases
Control of alpha subunit of eukaryotic translation initiation factor 2 (eIF2 alpha) phosphorylation by the human papillomavirus type 18 E6 oncoprotein: implications for eIF2 alpha-dependent gene expression and cell death.
Virus Diseases
Deep sequencing leads to the identification of eukaryotic translation initiation factor 5a as a key element in Rsv1-mediated lethal systemic hypersensitive response to Soybean mosaic virus infection in Soybean.
Virus Diseases
Double-stranded RNA-activated protein kinase PKR of fishes and amphibians: varying the number of double-stranded RNA binding domains and lineage-specific duplications.
Virus Diseases
dsRNA Binding Domain of PKR Is Proteolytically Released by Enterovirus A71 to Facilitate Viral Replication.
Virus Diseases
eIF2? of Litopenaeus vannamei involved in shrimp immune response to WSSV infection.
Virus Diseases
Enhancement of osteoblastogenesis and suppression of osteoclastogenesis by inhibition of de-phosphorylation of eukaryotic translation initiation factor 2 alpha.
Virus Diseases
Evidence of viral genome linked protein of banana bract mosaic virus interaction with translational eukaryotic initiation factor 4E of plantain cv. Nendran based on yeast two hybrid system study.
Virus Diseases
GCN2 has inhibitory effect on human immunodeficiency virus-1 protein synthesis and is cleaved upon viral infection.
Virus Diseases
GCN2-dependent phosphorylation of eukaryotic translation initiation factor-2alpha in Arabidopsis.
Virus Diseases
Gene expression in peripheral blood mononuclear cells from patients with chronic fatigue syndrome.
Virus Diseases
HRI of Epinephelus coioides is a critical factor in the grouper immune response to RGNNV infection.
Virus Diseases
Inactivation of the PKR protein kinase and stimulation of mRNA translation by the cellular co-chaperone P58(IPK) does not require J domain function.
Virus Diseases
Inhibition of cellular 2'-5' oligoadenylate synthetase by the herpes simplex virus type 1 Us11 protein.
Virus Diseases
Inhibition of eIF2? Phosphorylation by Peste des Petits Ruminant Virus Phosphoprotein Facilitates Viral Replication.
Virus Diseases
Inhibition of host and viral translation during vesicular stomatitis virus infection. eIF2 is responsible for the inhibition of viral but not host translation.
Virus Diseases
Inhibitory sequences in the N-terminus of the double-stranded-RNA-dependent protein kinase, PKR, are important for regulating phosphorylation of eukaryotic initiation factor 2alpha (eIF2alpha).
Virus Diseases
Interaction between RAX and PKR modulates the effect of ethanol on protein synthesis and survival of neurons.
Virus Diseases
Involvement of eIF2? of Epinephelus coioides in the fish immune response to virus infection.
Virus Diseases
Life as a Vector of Dengue Virus: The Antioxidant Strategy of Mosquito Cells to Survive Viral Infection.
Virus Diseases
LreEF1A4, a Translation Elongation Factor from Lilium regale, Is Pivotal for Cucumber Mosaic Virus and Tobacco Rattle Virus Infections and Tolerance to Salt and Drought.
Virus Diseases
Phosphorylation state of the cap-binding protein eIF4E during viral infection.
Virus Diseases
PKR activity modulation by phosphomimetic mutations of serine residues located three aminoacids upstream of double-stranded RNA binding motifs.
Virus Diseases
Plant Translation Elongation Factor 1B? Facilitates Potato Virus X (PVX) Infection and Interacts with PVX Triple Gene Block Protein 1.
Virus Diseases
PmTBC1D20, a Rab GTPase-activating protein from the black tiger shrimp, Penaeus monodon, is involved in white spot syndrome virus infection.
Virus Diseases
Rapid evolution of protein kinase PKR alters sensitivity to viral inhibitors.
Virus Diseases
Regulation of de novo Translation of Host Cells by Manipulation of PERK/PKR and GADD34-PP1 Activity during Newcastle Disease Virus Infection.
Virus Diseases
Regulation of internal ribosomal entry site-mediated translation by phosphorylation of the translation initiation factor eIF2alpha.
Virus Diseases
Regulation of starvation- and virus-induced autophagy by the eIF2alpha kinase signaling pathway.
Virus Diseases
Resistance of mRNA translation to acute endoplasmic reticulum stress-inducing agents in herpes simplex virus type 1-infected cells requires multiple virus-encoded functions.
Virus Diseases
Resistance to vesicular stomatitis virus infection requires a functional cross talk between the eukaryotic translation initiation factor 2alpha kinases PERK and PKR.
Virus Diseases
Ribosome targeting of PKR is mediated by two double-stranded RNA-binding domains and facilitates in vivo phosphorylation of eukaryotic initiation factor-2.
Virus Diseases
Rotavirus infection induces the phosphorylation of eIF2alpha but prevents the formation of stress granules.
Virus Diseases
Significance of eukaryotic translation elongation factor 1A in tobacco mosaic virus infection.
Virus Diseases
Sindbis virus translation is inhibited by a PKR/RNase L-independent effector induced by alpha/beta interferon priming of dendritic cells.
Virus Diseases
Stress granule formation induced by measles virus is protein kinase PKR dependent and impaired by RNA adenosine deaminase ADAR1.
Virus Diseases
Structural requirements for double-stranded RNA binding, dimerization, and activation of the human eIF-2 alpha kinase DAI in Saccharomyces cerevisiae.
Virus Diseases
Suppression of osteoclastogenesis through phosphorylation of eukaryotic translation initiation factor 2 alpha.
Virus Diseases
Tellurium/Bovine Serum Albumin Nanocomposites Inducing the Formation of Stress Granules in a Protein Kinase R-Dependent Manner.
Virus Diseases
The African swine fever virus DP71L protein recruits the protein phosphatase 1 catalytic subunit to dephosphorylate eIF2alpha and inhibits CHOP induction but is dispensable for these activities during virus infection.
Virus Diseases
The Atlantic salmon Z-DNA binding protein kinase phosphorylates translation initiation factor 2 alpha and constitutes a unique orthologue to the mammalian dsRNA-activated protein kinase R.
Virus Diseases
The cellular inhibitor of the PKR protein kinase, P58(IPK), is an influenza virus-activated co-chaperone that modulates heat shock protein 70 activity.
Virus Diseases
The direct binding of the catalytic subunit of protein phosphatase 1 to the PKR protein kinase is necessary but not sufficient for inactivation and disruption of enzyme dimer formation.
Virus Diseases
The eEF1A Proteins: At the Crossroads of Oncogenesis, Apoptosis, and Viral Infections.
Virus Diseases
The Eukaryotic Translation Initiation Factor 4F Complex Restricts Rotavirus Infection via Regulating the Expression of IRF1 and IRF7.
Virus Diseases
The vaccinia virus bifunctional gene J3 (nucleoside-2'-O-)-methyltransferase and poly(A) polymerase stimulatory factor is implicated as a positive transcription elongation factor by two genetic approaches.
Virus Diseases
The vaccinia virus E3L gene product interacts with both the regulatory and the substrate binding regions of PKR: implications for PKR autoregulation.
Virus Diseases
Translation elongation factor 1B (eEF1B) is an essential host factor for Tobacco mosaic virus infection in plants.
Virus Diseases
Translational resistance of late alphavirus mRNA to eIF2alpha phosphorylation: a strategy to overcome the antiviral effect of protein kinase PKR.
Virus Diseases
Variola virus E3L Z? domain, but not its Z-DNA binding activity, is required for PKR inhibition.
Whooping Cough
Immunochemical detection of guanine nucleotide binding proteins mono-ADP-ribosylated by bacterial toxins.
Xeroderma Pigmentosum
[Screening of binding proteins to interferon-alpha promoter DNA by phage display technique]
Yellow Fever
The eukaryotic translation initiation factor 3 subunit L protein interacts with Flavivirus NS5 and may modulate yellow fever virus replication.
Zika Virus Infection
Flavivirus Infection Uncouples Translation Suppression from Cellular Stress Responses.
Zika Virus Infection
The Unique Cofactor Region of Zika Virus NS2B-NS3 Protease Facilitates Cleavage of Key Host Proteins.
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
subunits EIF2S1, EIF2S2 and EIF2S3 or eIF-2-alpha, eIF-2-beta, and eIF-2-gamma, respectively
P05198; P20042; P41091
UniProt
brenda
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LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
-
EF-G1mt is active on both bacterial and mitochondrial ribosomes
brenda
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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
malfunction
mutations of the conservative histidine H715 residue located at the tip of domain IV decreases the rate of mRNA translocation. ADP-ribosylation of eEF2 domain IV blocks reverse translocation activity of eEF2. ADP-ribosylation may directly interrupt the ability of eEF2 to stabilize the intermediate conformation of the tRNA ends during their movement through the SSU in the course of translocation
metabolism
physiological function
additional information
metabolism
P05198; P20042; P41091
IF2alpha is phosphorylated at Ser51 by four kinases in what is collectively known as the integrated stress response (ISR)
metabolism
in human, eIF5B displacing eIF2 from Met-tRNAi upon subunit joining may be coupled to eIF1A displacing eIF5 from eIF5B, allowing the eIF5:eIF2-GDP complex to leave the ribosome
physiological function
P05198; P20042; P41091
eukaryotic translation initiation factor 2 (eIF2) is a heterotrimeric GTPase (cf. EC 3.6.5.1), which plays a critical role in protein synthesis regulation. eIF2-GTP binds MettRNAi to form the eIF2-GTP-Met-tRNAi ternary complex (TC), which is recruited to the 40S ribosomal subunit. Following GTP hydrolysis, eIF2-GDP is recycled back to TC by its guanine nucleotide exchange factor (GEF), eIF2B (i.e. eIF-2B GDP-GTP exchange factor). Mechanisms of eIF2B action and its regulation by phosphorylation of the substrate eIF2, overview. eIF2 consists of alpha, beta, and gamma subunits, with eIF2gamma being the actual GTPase, and eIF2alpha and beta serving accessory functions. eIF2B is inhibited by phosphorylated eIF2, eIF2(alpha-P)-GDP. Modeling of the structural and thermodynamic basis of the eIF2B/eIF2 and eIF2B/eIF2(alpha-P) interactions and the mechanism of catalysis, and modelling of the structural mechanism of IF2B inhibition by eIF2(alpha-P)-GDP, detailed overview
physiological function
eukaryotic translation initiation is a multistep process requiring a number of eukaryotic translation initiation factors (eIFs). Two GTPases play key roles in the process. EIF2 brings the initiator Met-tRNAi to the preinitiation complex (PIC). Upon start codon selection and GTP hydrolysis promoted by the GTPase-activating protein (GAP) eIF5, eIF2-GDP is displaced from Met-tRNAi by eIF5B-GTP and is released in complex with eIF5. EIF5B promotes ribosomal subunit joining, with the help of eIF1A. Upon subunit joining, eIF5B hydrolyzes GTP and is released together with eIF1A. EIF5 promotes GTP hydrolysis by eIF2, followed by phosphate release. eIF2-GDP has lower affinity for Met-tRNAi than eIF2-GTP, and is released together with its GAP, eIF5. Possible mechanism for coordination between the two steps in translation initiation controlled by GTPases: start codon selection and ribosomal subunit joining, overview
physiological function
eukaryotic translation initiation is a multistep process requiring a number of eukaryotic translation initiation factors (eIFs). Two GTPases play key roles in the process. EIF2 brings the initiator Met-tRNAi to the preinitiation complex (PIC). Upon start codon selection and GTP hydrolysis promoted by the GTPase-activating protein (GAP) eIF5, eIF2-GDP is displaced from Met-tRNAi by eIF5B-GTP and is released in complex with eIF5. EIF5B promotes ribosomal subunit joining, with the help of eIF1A. Upon subunit joining, eIF5B hydrolyzes GTP and is released together with eIF1A. Possible mechanism for coordination between the two steps in translation initiation controlled by GTPases: start codon selection and ribosomal subunit joining, overview
physiological function
one of the final maturation steps of the large ribosomal subunit requires the joint action of the elongation factor-like 1 (EFL1) GTPase and the Shwachman-Diamond syndrome protein (SBDS) to release the eukaryotic translation initiation factor 6 (eIF6) and allow the assembly of mature ribosomes. EFL1 function is driven by conformational changes
physiological function
the eukaryotic elongation factor eEF2 catalyzes ribosomal reverse translocation at one mRNA triplet. This process requires a cognate tRNA in the ribosomal E-site and cannot occur spontaneously without eEF2. The efficiency of this reaction depends on the concentrations of eEF2 and cognate tRNAs and increases in the presence of nonhydrolyzable GTP analogues. Crucial role of interactions of domain IV of eEF2 with the ribosome for the catalysis of the reverse translocation reaction. eEF2 is able to induce ribosomal translocation in forward and backward directions, highlighting the universal mechanism of tRNA-mRNA movements within the ribosome. During forward translocation, eEF2 binds to the PRE complex, capable of undergoing spontaneous conformational changes, including an intersubunit rotation of the ribosomal subunits. During reverse translocation, eEF2 binds to the POST complex, which has a conformation of unrotated ribosomal subunits because no tRNAs with hybrid acceptor ends are present therein. Reverse translocation requires an excessive concentration of cognate deacylated tRNA
additional information
human eIF5 competes with eIF1A for binding and has about 100fold higher affinity for eIF5B
additional information
P05198; P20042; P41091
human eIF5 competes with eIF1A for binding and has about 100fold higher affinity for eIF5B
additional information
-
human eIF5 competes with eIF1A for binding and has about 100fold higher affinity for eIF5B
additional information
P05198; P20042; P41091
modeling of the closed conformation of eIF2alpha, the model is generated from the structure of human eIF2alpha (PDB ID 1Q8K), based on the intramolecular contact interface mapped using CSPs from the NMR deletion analysis, comparing spectra of full-length eIF2alpha with those of its individual domains, eIF2alpha-NTD and -CTD, docking analysis and comparisons with the structure of Schizosaccharomyces pombe, intramolecular interaction in eIF2alpha. Further structure modeling of eIF2alpha binding in the eIF2Breg regulatory subcomplex pocket, eIF2B complex with eIF2-GTP-Met-tRNAi ternary complex, eIF2B complex with eIF2 in an extended conformation, and eIF2B complex with eIF2 in closed conformation. eIF2alpha-NTD interactions with the eIF2Breg pocket play a role in catalysis, and not just in eIF2B inhibition by phosphorylated eIF2-GDP (eIF2(alpha-P)-GDP). The primary mechanism responsible for the increased affinity of eIF2B for eIF2(alpha-P)-GDP over unphosphorylated eIF2-GDP is the direct effect of phosphorylation on the affinity of the eIF2x02 phosphorylation loop (P-loop) for a corresponding surface on eIF2B. eIF2Balpha and eIF2Bbeta bind to adjacent surfaces on eIF2-N-terminal domain (NTD), and eIF2Balpha, eIF2Bbeta, and eIF2Breg show no significant preference for phosphomimetic over wild-type eIF2alpha-NTD, binding analysis, overview
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UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). IF2G_HUMAN
472
0
51109
Swiss-Prot
other Location (Reliability: 2)
IF2GL_HUMAN
472
0
51229
Swiss-Prot
other Location (Reliability: 2)
IF2P_HUMAN
1220
0
138827
Swiss-Prot
other Location (Reliability: 1)
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PDB
SCOP
CATH
UNIPROT
ORGANISM
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POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
phosphoprotein
phosphoprotein
-
recombinant subunits of eIF2alpha and beta-subunits are also phosphorylated in cultured insect cells. Phosphorylation of eIF2alpha in vitro is not significantly different in the presence and absence of the other subunits
phosphoprotein
P05198; P20042; P41091
IF2alpha is phosphorylated at Ser51 by four kinases in what is collectively known as the integrated stress response (ISR). Phosphorylation of Ser51 disrupts an intramolecular interaction between eIF2alpha-NTD and -CTD. This disruption exposes an eIF2B-binding surface on eIF2alpha-NTD that is otherwise obstructed by eIF2alpha-CTD. The intramolecular binding interface in eIF2alpha overlaps with the eIF2alpha binding surfaces for eIF2Bbeta, and possibly also eIF2Bdelta, in support of the hypothesis for an indirect effect of eIF2alpha phosphorylation on eIF2B-eIF2 binding. Phosphorylation destabilizes the eIF2alpha intramolecular interaction
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CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
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PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
recombinant GB1-His6-tagged wild-type eIF5B and truncated mutants eIF5B587-1220 (GH-DELTAeIF5B), eIF5B951-1220 comprising domains 3 and 4 (GH-eIF5B-D34), and eIF5B1076-1220 comprising domain 4 (GH-eIF5B-D4) by nickel affinity chromatography, tag cleavage by TEV protease, and anion exchange chromatography to remove the GB1 tag
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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
gene EIF2B1, recombinant expression of C-terminally His6-tagged eIF2B subunit alpha in Escherichia coli strain Rosetta2(DE3)
P05198; P20042; P41091
overexpression of all three subunits of human eIEF2 independently, and together in Sf9 cells using pFast Bac HT vector of baculovirus expression system. the expression of all subunits increases in infection time up to 72 h. Expression of the mutant forms S51A, S51D and S48A
-
recombinant expression of wild-type eIF5B and truncated mutants eIF5B587-1220 (GH-DELTAeIF5B), eIF5B951-1220 comprising domains 3 and 4 (GH-eIF5B-D34), and eIF5B1076-1220 comprising domain 4 (GH-eIF5B-D4), all with an N-terminal GB1 tag, His6-tag, and a TEV protease cleavage site (GH-tag)
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Bieniossek, C.; Schuetz, P.; Bumann, M.; Limacher, A.; Uson, I.; Baumann, U.
The crystal structure of the carboxy-terminal domain of human translation initiation factor eIF5
J. Mol. Biol.
360
457-465
2006
Homo sapiens
brenda
Dubovaya, V.I.; Kolosov, P.M.; Alkalaeva, E.Z.; Frolova, L.Y.; Kisselev, L.L.
Influence of individual domains of the translation termination factor eRF1 on induction of the GTPase activity of the translation termination factor eRF3
Mol. Biol.
40
270-275
2006
Homo sapiens
-
brenda
Bhargava, K.; Templeton, P.; Spremulli, L.L.
Expression and characterization of isoform 1 of human mitochondrial elongation factor G
Protein Expr. Purif.
37
368-376
2004
Homo sapiens
brenda
Suragani, R.N.; Ghosh, S.; Ehtesham, N.Z.; Ramaiah, K.V.
Expression and purification of the subunits of human translational initiation factor 2 (eIF2): phosphorylation of eIF2alpha and beta
Protein Expr. Purif.
47
225-233
2006
Homo sapiens
brenda
Lin, K.Y.; Nag, N.; Pestova, T.V.; Marintchev, A.
Human eIF5 and eIF1A compete for binding to eIF5B
Biochemistry
57
5910-5920
2018
Homo sapiens (O60841), Homo sapiens (P05198 AND P20042 AND P41091), Homo sapiens
brenda
Luviano, A.; Cruz-Castaneda, R.; Sanchez-Puig, N.; Garcia-Hernandez, E.
Cooperative energetic effects elicited by the yeast Shwachman-Diamond syndrome protein (Sdo1) and guanine nucleotides modulate the complex conformational landscape of the elongation factor-like 1 (Efl1) GTPase
Biophys. Chem.
247
13-24
2019
Saccharomyces cerevisiae (P53893), Saccharomyces cerevisiae, Homo sapiens (Q7Z2Z2), Saccharomyces cerevisiae ATCC 204508 (P53893)
brenda
Susorov, D.; Zakharov, N.; Shuvalova, E.; Ivanov, A.; Egorova, T.; Shuvalov, A.; Shatsky, I.N.; Alkalaeva, E.
Eukaryotic translation elongation factor 2 (eEF2) catalyzes reverse translocation of the eukaryotic ribosome
J. Biol. Chem.
293
5220-5229
2018
Homo sapiens (P13639)
brenda
Bogorad, A.M.; Lin, K.Y.; Marintchev, A.
Novel mechanisms of eIF2B action and regulation by eIF2alpha phosphorylation
Nucleic Acids Res.
45
11962-11979
2017
Homo sapiens (P05198 AND P20042 AND P41091)
brenda
EXTERNAL LINKS (specific for EC-Number 3.6.5.3)
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Release 2023.1 (January 2023)
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