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Disease on EC 3.6.5.2 - small monomeric GTPase

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DISEASE
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Aberrant Crypt Foci
Aberrant crypt foci and K-ras mutations: earliest recognized players or innocent bystanders in colon carcinogenesis?
Altered expression of beta-catenin, inducible nitric oxide synthase and cyclooxygenase-2 in azoxymethane-induced rat colon carcinogenesis.
Analysis of K-ras, APC, and beta-catenin in aberrant crypt foci in sporadic adenoma, cancer, and familial adenomatous polyposis.
APC and K-ras gene mutation in aberrant crypt foci of human colon.
Cell cycle variations in azoxymethane-induced rat colorectal carcinogenesis studied by flow cytometry.
Detection of K-ras mutations in azoxymethane-induced aberrant crypt foci in mice using LNA -mediated real-time PCR clamping and mutant-specific probes.
DNA methylation patterns in adenomas from FAP, multiple adenoma and sporadic colorectal carcinoma patients.
Frequent and characteristic K-ras activation and absence of p53 protein accumulation in aberrant crypt foci of the colon.
Frequent and characteristic K-ras activation in aberrant crypt foci of colon. Is there preference among K-ras mutants for malignant progression?
Gene mutations and altered gene expression in azoxymethane-induced colon carcinogenesis in rodents.
Glutathione S-transferase-pi overexpression is closely associated with K-ras mutation during human colon carcinogenesis.
K-ras and p53 mutations in aberrant crypt foci and colonic tumors from colon cancer patients.
K-ras and p53 mutations in human colorectal aberrant crypt foci.
K-ras mutations and mucin profile in preneoplastic lesions and colon tumors induced in rats by 1,2-dimethylhydrazine.
K-ras mutations in aberrant crypt foci, adenomas and adenocarcinomas during azoxymethane-induced colon carcinogenesis.
K-ras mutations in putative preneoplastic lesions in human colon.
Molecular changes in the early stage of colon carcinogenesis in rats treated with azoxymethane.
O6-methylguanine-DNA methyltransferase promoter hypermethylation in colorectal carcinogenesis.
Oncogenic K-ras promotes early carcinogenesis in the mouse proximal colon.
Sequential analysis of K-ras mutations in aberrant crypt foci and colonic tumors induced by azoxymethane in Fischer-344 rats on high-risk diet.
Serrated route to colorectal cancer: back street or super highway?
Somatic APC and K-ras codon 12 mutations in aberrant crypt foci from human colons.
Suppression of colorectal oncogenesis by selenium-enriched milk proteins: apoptosis and K-ras mutations.
Suppressive effect of RAS inhibitor manumycin A on aberrant crypt foci formation in the azoxymethane-induced rat colorectal carcinogenesis model.
Transfection of K-rasAsp12 cDNA markedly elevates IL-1beta- and lipopolysaccharide-mediated inducible nitric oxide synthase expression in rat intestinal epithelial cells.
Transgenic expression of human MGMT protects against azoxymethane-induced aberrant crypt foci and G to A mutations in the K-ras oncogene of mouse colon.
[Genome analyses for precancerous lesions in the gastrointestinal tract]
[Mutations of APC and K-ras gene in aberrant crypt foci from human colon]
Abnormalities, Multiple
Cdc42 regulates cofilin during the establishment of neuronal polarity.
Abortion, Spontaneous
Instability at the H-ras minisatellite is associated with the spontaneous abortion of the embryo.
Acquired Immunodeficiency Syndrome
Cdk1 phosphorylation negatively regulates the activity of Net1 towards RhoA during mitosis.
Detection of K-ras mutations of bronchoalveolar lavage fluid cells aids the diagnosis of lung cancer in small pulmonary lesions.
Incidental Cystic Lesions in the Pancreas: Resect? EUS? Follow?
Spatial Distribution and Ribosome-Binding Dynamics of EF-P in Live Escherichia coli.
Acromegaly
Rab18 is reduced in pituitary tumors causing acromegaly and its overexpression reverts growth hormone hypersecretion.
Acute Lung Injury
Afadin controls p120-catenin - ZO-1 interactions leading to endothelial barrier enhancement by oxidized phospholipids.
Cingulin role in agonist-induced vascular endothelial permeability.
Endothelial Cdc42 deficiency impairs endothelial regeneration and vascular repair after inflammatory vascular injury.
Adenocarcinoma
A case of pancreatic adenocarcinoma with novel K-ras mutation and long term survival.
A case of pulmonary adenocarcinoma harboring osteoclast-like giant cells: Its evaluation by immunohistochemical and genetic analyses.
A Case Report of Long-Term Survival following Hepatic Arterial Infusion of L-Folinic Acid Modulated 5-Fluorouracil Combined with Intravenous Irinotecan and Cetuximab Followed by Hepatectomy in a Patient with Initially Unresectable Colorectal Liver Metastases.
A New Strategy to Control and Eradicate "Undruggable" Oncogenic K-RAS-Driven Pancreatic Cancer: Molecular Insights and Core Principles Learned from Developmental and Evolutionary Biology.
A phase II study of farnesyl transferase inhibitor R115777 in pancreatic cancer: a Southwest oncology group (SWOG 9924) study.
A prospective study of K-ras mutations in the plasma of pancreatic cancer patients.
A rapid PCR ELISA for the detection of activated K-ras in colorectal cancer.
A subset of lung adenocarcinomas and atypical adenomatous hyperplasia-associated foci are genotypically related: an EGFR, HER2, and K-ras mutational analysis.
A two-step enriched-nested PCR technique enhances sensitivity for detection of codon 12 K-ras mutations in pancreatic adenocarcinoma.
A universal method for the mutational analysis of K-ras and p53 gene in non-small-cell lung cancer using formalin-fixed paraffin-embedded tissue.
Aberrant overexpression of the Rgl2 Ral small GTPase-specific guanine nucleotide exchange factor promotes pancreatic cancer growth through Ral-dependent and Ral-independent mechanisms.
Activation of H-ras is prevalent in 1,3-butadiene-induced and spontaneously occurring murine Harderian gland tumors.
Activation of K-ras by codon 13 mutations in C57BL/6 X C3H F1 mouse tumors induced by exposure to 1,3-butadiene.
Activation of K-ras in transplantable pancreatic ductal adenocarcinomas of Syrian golden hamsters.
Activation of protooncogenes in spontaneously occurring non-liver tumors from C57BL/6 x C3H F1 mice.
Activation of Raf-1 in human pancreatic adenocarcinoma.
Additional K-ras mutation analysis and Plectin-1 staining improve the diagnostic accuracy of pancreatic solid mass in EUS-guided fine needle aspiration.
Adecatumumab: an anti-EpCAM monoclonal antibody, from the bench to the bedside.
Adenocarcinoma of the pancreas: detection of occult metastases in regional lymph nodes by a polymerase chain reaction-based assay.
Adenosquamous carcinoma of the pancreas: a clinicopathologic series of 25 cases.
Administration of Chemotherapy by an Arteriovenous Fistula in a Patient with Metastatic Rectal Cancer after Life-Threatening, Port Thrombosis-Associated Cava Superior Syndrome. An Option for Patients without Possibility of Peripheral or Central Venous Access.
Allosteric modulation of Ras and the PI3K/AKT/mTOR pathway: emerging therapeutic opportunities.
Alteration of the p53 tumor suppressor gene and activation of c-K-ras-2 protooncogene in endometrial adenocarcinoma from Colorado.
Alteration of the p53 tumor suppressor gene occurs independently of K-ras activation and more frequently in serous adenocarcinomas than in other common epithelial tumors of the human ovary.
Alterations of the p53 tumor suppressor gene and its association with activation of the c-K-ras-2 protooncogene in premalignant and malignant lesions of the human uterine endometrium.
Altered detoxification status and increased resistance to oxidative stress by K-ras transformation.
Altered expression of beta-catenin, inducible nitric oxide synthase and cyclooxygenase-2 in azoxymethane-induced rat colon carcinogenesis.
An integrated approach for comparative proteomic analysis of human bile reveals overexpressed cancer-associated proteins in malignant biliary stenosis.
Analysis and clinical implications of K-ras gene mutations and infection with human papillomavirus types 16 and 18 in primary adenocarcinoma of the uterine cervix.
Analysis of K-ras gene mutation in hyperplastic duct cells of the pancreas without pancreatic disease.
Analysis of K-ras gene mutations in human pancreatic cancer cell lines and in bile samples from patients with pancreatic and biliary cancers.
Analysis of K-ras gene mutations in lung carcinomas: correlation with gender, histological subtypes, and clinical outcome.
Analysis of K-ras gene mutations in rare pancreatic and ampullary tumours.
Analysis of K-ras mutations in pancreatic tissue after fine needle aspirates.
Analysis of K-ras, p53 and c-raf-1 mutations in beryllium-induced rat lung tumors.
Analysis of loss of heterozygosity in atypical and negative bile duct brushing cytology specimens with malignant outcome: are "false-negative" cytologic findings a representation of morphologically subtle molecular alterations?
Analysis of point mutations at codon 12 of K-ras in human endometrial carcinoma and cervical adenocarcinoma by dot blot hybridization and polymerase chain reaction.
Analysis of ras gene mutations in biliary and pancreatic tumors by polymerase chain reaction and direct sequencing.
Analysis of the K-ras and p53 pathways in X-ray-induced lung tumors in the rat.
Angiogenesis and p53 and H-ras mutations in pancreatic ductal adenocarcinoma.
Antroquinonol, a natural ubiquinone derivative, induces a cross talk between apoptosis, autophagy and senescence in human pancreatic carcinoma cells.
Association of H-ras mutations with adenocarcinomas of the parotid gland.
Association of K-ras codon 12 transversions with short survival in non-small cell lung cancer.
Association of matrilysin mRNA expression with K-ras mutations and progression in pancreatic ductal adenocarcinomas.
Automated real-time PCR to determine K-ras codon 12 mutations in non-small cell lung cancer: comparison with immunohistochemistry and clinico-pathological features.
Biological identification of ampullary adenocarcinomas.
BITC Sensitizes Pancreatic Adenocarcinomas to TRAIL-induced Apoptosis.
C-erbB-2 expression and codon 12 K-ras mutations both predict shortened survival for patients with pulmonary adenocarcinomas.
Can K-ras codon 12 mutations be used to distinguish benign bile duct proliferations from metastases in the liver? A molecular analysis of 101 liver lesions from 93 patients.
Carcinosarcoma colliding osteosarcoma of the pancreas: a rare case report of multiple clonal originated pancreatic tumors.
Cdc42 is highly expressed in colorectal adenocarcinoma and downregulates ID4 through an epigenetic mechanism.
CDDO-Me inhibits tumor growth and prevents recurrence of pancreatic ductal adenocarcinoma.
Cellular protoonocogenes are infrequently amplified in untreated non-small cell lung cancer.
Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinoma by K-Ras oncogenes in adult mice.
Cigarette smoking and K-ras mutations in pancreas, lung and colorectal adenocarcinomas: Etiopathogenic similarities, differences and paradoxes.
Cigarette smoking is strongly associated with mutation of the K-ras gene in patients with primary adenocarcinoma of the lung.
Circulating MicroRNAs in Serum of Human K-ras Oncogene Transgenic Rats With Pancreatic Ductal Adenocarcinomas.
Circulating miR-16-5p, miR-92a-3p, and miR-451a in Plasma from Lung Cancer Patients: Potential Application in Early Detection and a Regulatory Role in Tumorigenesis Pathways.
CK20 expression, CDX2 expression, K-ras mutation, and goblet cell morphology in a subset of lung adenocarcinomas.
Clinical application of K-ras oncogene mutations in pancreatic carcinoma: detection of micrometastases.
Clinical application of ras gene mutation for diagnosis of pancreatic adenocarcinoma.
Clinical impact of K-ras mutation analysis in EUS-guided FNA specimens from pancreatic masses.
Clinical significance of cathepsin E in pancreatic juice in the diagnosis of pancreatic ductal adenocarcinoma.
Clinical significance of K-ras and c-erbB-2 mutations in pancreatic adenocarcinoma and chronic pancreatitis.
Clinical significance of ras oncogene activation in human lung cancer.
Clinical usefulness of K-RAS mutation detection in colorectal cancer and in surgical margins of the colon.
Clinico-pathological study of K-ras mutations in colorectal tumors in Saudi Arabia.
Clinicopathologic analysis of k-ras, p53, and ERBB-2 gene alterations in pulmonary adenocarcinoma.
Clinicopathologic evaluation of the trend toward histologically poor differentiation with submucosal invasion in superficial early colorectal adenocarcinomas.
Clinicopathological and prognostic features of surgically resected pathological stage I lung adenocarcinoma harboring epidermal growth factor receptor and K-ras mutation.
Combined analysis of Rac1, IQGAP1, Tiam1 and E-cadherin expression in gastric cancer.
Comparison of K-ras point mutation distributions in intraductal papillary-mucinous tumors and ductal adenocarcinoma of the pancreas.
Contextual inhibition of fatty acid synthesis by metformin involves glucose-derived acetyl-CoA and cholesterol in pancreatic tumor cells.
Contrasting molecular pathology of colorectal carcinoma in Egyptian and Western patients.
Cooperative anti-invasive effect of Cdc42/Rac1 activation and ROCK inhibition in SW620 colorectal cancer cells with elevated blebbing activity.
Cooperativity of oncogenic K-ras and downregulated p16/INK4A in human pancreatic tumorigenesis.
Correlation Between RAB27B and p53 Expression and Overall Survival in Pancreatic Cancer.
Cribriform adenocarcinoma of minor salivary glands may express galectin-3, cytokeratin 19, and HBME-1 and contains polymorphisms of RET and H-RAS proto-oncogenes.
CtBP-a targetable dependency for tumor-initiating cell activity and metastasis in pancreatic adenocarcinoma.
Curative resection of hilar cholangiocarcinoma in a 25-year-old woman: report of a case.
Cyclooxygenase-2 expression in human pancreatic adenocarcinomas.
CYP1B1 Polymorphisms and K-ras Mutations in Patients with Pancreatic Ductal Adenocarcinoma.
Detection and clinical correlations of ras gene mutations in human ovarian tumors.
Detection of activated K-ras in non-small cell lung cancer by membrane array: a comparison with direct sequencing.
Detection of codon 12 mutation in the K-ras oncogene in pancreatic tumors.
Detection of extrapancreatic nerve plexus invasion of pancreatic adenocarcinoma. Cytokeratin 19 staining and K-ras mutation.
Detection of genetic abnormalities in neoplasms from Greek patients with FAP.
Detection of hepatic micrometastasis in pancreatic adenocarcinoma patients by two-stage polymerase chain reaction/restriction fragment length polymorphism analysis.
Detection of K-ras gene mutations in non-neoplastic lung tissue and lung cancers.
Detection of K-ras gene mutations in plasma DNA of patients with pancreatic adenocarcinoma: correlation with clinicopathological features.
Detection of K-ras mutation in colonic effluent samples from patients without evidence of colorectal carcinoma.
Detection of K-ras mutation in sputum by mutant-allele-specific amplification (MASA).
Detection of K-ras mutations in cancerous lesions of human endometrium.
Detection of K-ras mutations in DNAs isolated from feces of patients with colorectal tumors by mutant-allele-specific amplification (MASA).
Detection of K-ras mutations in lung carcinomas: relationship to prognosis.
Detection of K-ras mutations in mucinous pancreatic duct hyperplasia from a patient with a family history of pancreatic carcinoma.
Detection of K-ras mutations in the stool of patients with pancreatic adenocarcinoma and pancreatic ductal hyperplasia.
Detection of K-Ras mutations in tumour samples of patients with non-small cell lung cancer using PNA-mediated PCR clamping.
Detection of K-ras point mutation by enriched PCR-colorimetric plate assay.
Detection of K-ras point mutations in sputum from patients with adenocarcinoma of the lung by point-EXACCT.
Detection of low-fraction K-ras mutations in primary lung tumors using a sensitive method.
Detection of multiple hepatic micrometastases in pancreatic adenocarcinoma with a solitary liver metastasis by direct sequencing of the K-ras gene: a case report.
Detection of mutant K-ras in dissected paraaortic lymph nodes of patients with pancreatic adenocarcinoma.
Detection of point mutation in K-ras oncogene at codon 12 in pancreatic diseases.
Detection of ras gene mutations in human lung cancer: comparison of two screening assays based on the polymerase chain reaction.
Detection of ras gene mutations in pancreatic juice and peripheral blood of patients with pancreatic adenocarcinoma.
Detection of the mutated K-Ras biomarker in colorectal carcinoma.
Dextran sodium sulfate strongly promotes colorectal carcinogenesis in Apc(Min/+) mice: inflammatory stimuli by dextran sodium sulfate results in development of multiple colonic neoplasms.
Diagnostic value of digital droplet polymerase chain reaction and digital multiplexed detection of single-nucleotide variants in pancreatic cytology specimens collected by EUS-guided FNA.
Diagnostic value of K-ras mutation analysis for pancreaticobiliary cytology specimens with indeterminate diagnosis.
Dietary folate intake and k-ras mutations in sporadic colon and rectal cancer in The Netherlands Cohort Study.
Dietary, lifestyle and clinicopathological factors associated with BRAF and K-ras mutations arising in distinct subsets of colorectal cancers in the EPIC Norfolk study.
Differences in K-ras and p53 gene mutations among pancreatic adenocarcinomas associated with regional environmental pollution.
Differential role of Interleukin-1 and Interleukin-6 in K-Ras-driven pancreatic carcinoma undergoing mesenchymal transition.
Differentially expressed genes associated with mouse lung tumor progression.
Discordance of Mutation Statuses of Epidermal Growth Factor Receptor and K-ras between Primary Adenocarcinoma of Lung and Brain Metastasis.
Disruption of actin filaments and suppression of pancreatic cancer cell viability and migration following treatment with polyisoprenylated cysteinyl amides.
Dissected peripancreatic tissue margin is a critical prognostic factor and is associated with a K-ras gene mutation in pancreatic ductal adenocarcinoma.
Distinctive evaluation of nonmucinous and mucinous subtypes of bronchioloalveolar carcinomas in EGFR and K-ras gene-mutation analyses for Japanese lung adenocarcinomas: confirmation of the correlations with histologic subtypes and gene mutations.
Distinctive molecular genetic alterations in sporadic and familial adenomatous polyposis-associated pancreatoblastomas : frequent alterations in the APC/beta-catenin pathway and chromosome 11p.
Distribution of p53 and K-ras mutations in human lung cancer tissues.
DNA repair: counteragent in mutagenesis and carcinogenesis-- accomplice in cancer therapy resistance.
Do molecular markers predict survival in non-small-cell lung cancer?
DPC-4 (Smad-4) and K-ras gene mutations in biliary tract epithelium in children with anomalous pancreaticobiliary ductal union.
Ductal origin of pancreatic adenocarcinomas induced by conditional activation of a human Ha-ras oncogene in rat pancreas.
Early growth response-1 induces and enhances vascular endothelial growth factor-a expression in lung cancer cells.
East meets West: ethnic differences in epidemiology and clinical behaviors of lung cancer between East Asians and Caucasians.
Effect of polyamine oxidase inhibition on the colonic malignant transformation process induced by 1,2-dimethylhydrazine.
Effects of K-ras gene mutations in the development of lung lesions induced by 4-(N-methyl-n-nitrosamino)-1-(3-pyridyl)-1-butanone in A/J mice.
Effects of Rab27A and Rab27B on Invasion, Proliferation, Apoptosis, and Chemoresistance in Human Pancreatic Cancer Cells.
Effects of vitamin D in lung, stomach, esophagus and testis tissues following administration of urethane in balb/c mice.
EGF receptor signaling is essential for k-ras oncogene-driven pancreatic ductal adenocarcinoma.
EGFR and K-ras mutations along the spectrum of pulmonary epithelial tumors of the lung and elaboration of a combined clinicopathologic and molecular scoring system to predict clinical responsiveness to EGFR inhibitors.
EGFR and K-Ras mutations in women with lung adenocarcinoma: implications for treatment strategy definition.
EGFR autophosphorylation but not protein score correlates with histologic and molecular subtypes in lung adenocarcinoma.
Enhanced Krev-1 expression inhibits the growth of pancreatic adenocarcinoma cells.
EphA2 in the early pathogenesis and progression of non-small cell lung cancer.
Epigenetic inactivation of tumor suppressor SFRP2 and point mutation in KRAS proto-oncogene in fistula-associated mucinous type anal adenocarcinoma: report of two cases.
Evaluation of K-ras and p53 expression in pancreatic adenocarcinoma using the cancer genome atlas.
Evolution of intratumoral genetic heterogeneity during colorectal cancer progression.
Expression of Elongation Factor (EF)-Tu Is Correlated with Prognosis of Gastric Adenocarcinomas.
Expression of Ki-67, p53, and K-ras in chronic pancreatitis and pancreatic ductal adenocarcinoma.
Expression of oncogenic K-ras and loss of Smad4 cooperate to induce the expression of EGFR and to promote invasion of immortalized human pancreas ductal cells.
Expression of the ras-related rap genes in human tumors.
Expression profile-defined classification of lung adenocarcinoma shows close relationship with underlying major genetic changes and clinicopathologic behaviors.
Expression profiles of pancreatic cancer cell lines infected with antisense K-ras-expressing adenoviral vector.
Fat and K-ras mutations in sporadic colorectal cancer in The Netherlands Cohort Study.
Frequency and spectrum of K-RAS codons 12 and 13 mutations in colorectal adenocarcinomas from Taiwan.
Frequency of K-ras mutations in pancreatic intraductal neoplasias associated with pancreatic ductal adenocarcinoma and chronic pancreatitis: a meta-analysis.
Frequent and characteristic K-ras activation and absence of p53 protein accumulation in aberrant crypt foci of the colon.
Frequent and characteristic K-ras activation in aberrant crypt foci of colon. Is there preference among K-ras mutants for malignant progression?
Frequent K-ras mutations in small bowel adenocarcinomas.
Frequent RASSF1A promoter hypermethylation and K-ras mutations in pancreatic carcinoma.
Gene analysis of K-, H-ras, p53, and retinoblastoma susceptibility genes in human lung cancer cell lines by the polymerase chain reaction/single-strand conformation polymorphism method.
Gene mutations and altered gene expression in azoxymethane-induced colon carcinogenesis in rodents.
Gene therapy for pancreatic and biliary malignancies.
Genetic alterations in mouse lung tumors: implications for cancer chemoprevention.
Genetic alterations in p53 and k-ras in lung-cancer in relation to histopathology of the tumor and smoking history of the patient.
Genetic Alterations of K-ras, p53, c-erbB-2, and DPC4 in Pancreatic Ductal Adenocarcinoma and Their Correlation With Patient Survival.
Genetic analysis of sinonasal adenocarcinoma phenotypes: distinct alterations of histogenetic significance.
Genetic interaction between Rb and K-ras in the control of differentiation and tumor suppression.
Genetically Engineered Mouse Models of K-Ras-Driven Lung and Pancreatic Tumors: Validation of Therapeutic Targets.
Glutathione S-transferase mu1 null genotype is associated with K-ras gene mutation in lung adenocarcinoma among smokers.
Growth factor-dependent activation of the Ras-Raf-MEK-MAPK pathway in the human pancreatic carcinoma cell line PANC-1 carrying activated K-ras: implications for cell proliferation and cell migration.
Growth inhibition of a colonic adenocarcinoma cell line (HT29) by T cells specific for mutant p21 ras.
GSTM1, P53 and K-ras molecular detection in resectable non-small cell lung cancer by denaturing gradient gel electrophoresis-bronchoalveolar lavage fluid analysis.
High Expression of Cell Division Cycle 42 Promotes Pancreatic Cancer Growth and Predicts Poor Outcome of Pancreatic Cancer Patients.
High expression of RAB27A and TP53 in pancreatic cancer predicts poor survival.
High expression of RAB38 promotes malignant progression of pancreatic cancer.
High incidence of point mutation in K-ras codon 12 in carcinoma of the fallopian tube.
High K-ras mutation rates in goblet-cell-type adenocarcinomas of the lungs.
High yields of K-ras mutations in intraductal papillary mucinous tumors and invasive adenocarcinomas induced by N-nitroso(2-hydroxypropyl)(2-oxopropyl)amine in the pancreas of female Syrian hamsters.
Human Papillomavirus DNA and Oncogene Alterations in Colorectal Tumors.
Identification of biomarkers and their functions in dasatinib-resistant pancreatic cancer using bioinformatics analysis.
Immunohistochemical evaluation of K-ras, p53, and HER-2/neu expression in hyperplastic, dysplastic, and carcinomatous lesions of the pancreas: evidence for multistep carcinogenesis.
Immunophenotype and K-RAS mutation in mucinous ovarian adenocarcinoma with mural nodule of high-grade sarcoma: case report.
Implications and prognostic value of K-ras mutation for early-stage lung cancer in women.
Inactivation of Rab23 inhibits the invasion and motility of pancreatic duct adenocarcinoma.
Incidence and possible clinical significance of K-ras oncogene activation in adenocarcinoma of the human lung.
Increased immunoreactivity for Rab11, a small GTP-binding protein, in low-grade dysplastic Barrett's epithelia.
Increased telomerase activities in human pancreatic duct adenocarcinomas.
Induction of mammary cancer and lymphoma by multiple, low oral doses of 7,12-dimethylbenz[a]anthracene in SENCAR mice.
Infrequent K-ras activation in superficial-type (flat) colorectal adenomas and adenocarcinomas.
Inhibition of mammalian target of rapamycin reverses alveolar epithelial neoplasia induced by oncogenic K-ras.
Inhibition of pancreatic adenocarcinoma cell growth by lovastatin.
Inhibition of RAS-mediated transformation and tumorigenesis by targeting the downstream E3 ubiquitin ligase seven in absentia homologue.
Integrated analysis and knockdown of RAB23 indicate the role of RAB23 in gastric adenocarcinoma.
Interaction between smoking and asbestos in human lung adenocarcinoma: role of K-ras mutations.
Intracellular HMGB1 as a novel tumor suppressor of pancreatic cancer.
Intradermal ras peptide vaccination with granulocyte-macrophage colony-stimulating factor as adjuvant: Clinical and immunological responses in patients with pancreatic adenocarcinoma.
Intraductal papillary mucinous tumors: a case report and review of literature.
Invasive ductal adenocarcinoma of the remnant pancreatic body 9 years after resection of an intraductal papillary-mucinous carcinoma of the pancreatic head: a case report and comparison of DNA sequence in K-ras gene mutation.
Inverse relationship between APC gene mutation in gastric adenomas and development of adenocarcinoma.
Investigation of c-myc and K-ras amplification in renal clear cell adenocarcinoma.
K-ras 4A and 4B are co-expressed widely in human tissues, and their ratio is altered in sporadic colorectal cancer.
K-ras activation generates an inflammatory response in lung tumors.
K-ras activation in non-small cell lung cancer in the dog.
K-ras activation in premalignant and malignant epithelial lesions of the human uterus.
K-Ras and cyclooxygenase-2 coactivation augments intraductal papillary mucinous neoplasm and Notch1 mimicking human pancreas lesions.
K-ras and Dpc4 mutations in chronic pancreatitis: case series.
K-ras and p53 alterations in genomic DNA and transcripts of human pancreatic adenocarcinoma cell lines.
K-ras and p53 mutations in hamster pancreatic ductal adenocarcinomas and cell lines.
K-ras and p53 mutations in the pathogenesis of classical and goblet cell carcinoids of the appendix.
K-ras and rho A mutations in malignant pleural effusion.
K-ras codon 12 mutations detected with enriched PCR method in operable non-small cell lung cancer.
K-ras codon 12 mutations in Barrett's oesophagus and adenocarcinomas of the oesophagus and oesophagogastric junction.
K-ras codon 12 mutations of the super-minute dysplasia in Barrett's esophagus by DNA extraction using a microdissection method.
K-ras gene mutation enhances motility of immortalized airway cells and lung adenocarcinoma cells via Akt activation: possible contribution to non-invasive expansion of lung adenocarcinoma.
K-ras gene mutation in sputum samples containing atypical cells and adenocarcinoma cells in the lung.
K-ras gene mutations in intrahepatic bile duct tumors of Syrian golden hamsters.
K-ras gene point mutation: a stable tumor marker in non-small cell lung carcinoma.
K-ras gene point mutations and p21ras immunostaining in human ovarian tumors.
K-RAS Mutant Gene Found in Pancreatic Juice Activated Chromatin From Peri-ampullary Adenocarcinomas.
K-ras mutation analysis of residual liquid-based cytology specimens from endoscopic ultrasound-guided fine needle aspiration improves cell block diagnosis of pancreatic ductal adenocarcinoma.
k-ras mutation and occupational asbestos exposure in lung adenocarcinoma: asbestos-related cancer without asbestosis.
K-ras mutation and p16 and preproenkephalin promoter hypermethylation in plasma DNA of pancreatic cancer patients: in relation to cigarette smoking.
K-ras mutation and pancreatic adenocarcinoma.
K-ras mutation at codon 12 in stage I pancreatic adenocarcinoma: analysis by laser capture microdissection and direct sequencing.
K-ras mutation in focal proliferative lesions of human pancreas.
K-ras mutation in Greek patients with poorly and moderately differenciated tumours of the lower intestinal tract.
K-ras mutation in sputum of primary lung cancer patients does not always reflect that of cancerous cells.
K-ras mutation is an early event in pancreatic duct carcinogenesis in the Syrian golden hamster.
K-Ras mutation-mediated IGF-1-induced feedback ERK activation contributes to the rapalog resistance in pancreatic ductal adenocarcinomas.
K-ras mutations and allelic loss at 5q and 18q in the development of human pancreatic cancers.
K-ras mutations appear in the premalignant phase of both microsatellite stable and unstable endometrial carcinogenesis.
K-ras mutations are frequent in pulmonary squamous cell carcinomas but not in adenocarcinomas of WBN/Kob rats induced by N-nitrosobis(2-oxopropyl)amine.
K-ras mutations in aberrant crypt foci, adenomas and adenocarcinomas during azoxymethane-induced colon carcinogenesis.
K-ras mutations in colorectal adenocarcinomas and neighbouring transitional mucosa.
K-ras mutations in DNA extracted from the plasma of patients with pancreatic carcinoma: diagnostic utility and prognostic significance.
K-ras mutations in human adenocarcinoma of the lung: association with smoking and occupational exposure to asbestos.
K-Ras Mutations in Non-Small-Cell Lung Cancer: Prognostic and Predictive Value.
K-ras mutations in patients with early colorectal cancers.
K-ras mutations in sinonasal adenocarcinomas in patients occupationally exposed to wood or leather dust.
K-ras mutations in sinonasal cancers in relation to wood dust exposure.
K-ras mutations in stools and tissue samples from patients with malignant and nonmalignant pancreatic diseases.
K-ras mutations in the duodenal fluid of patients with pancreatic carcinoma.
K-ras mutations in tissue and stool samples from patients with pancreatic cancer and chronic pancreatitis.
K-RAS mutations indicating primary resistance to crizotinib in ALK-rearranged adenocarcinomas of the lung: Report of two cases and review of the literature.
K-ras oncogene activation as a prognostic marker in adenocarcinoma of the lung.
K-ras oncogene activation in adenocarcinoma of the human pancreas. A study of 82 carcinomas using a combination of mutant-enriched polymerase chain reaction analysis and allele-specific oligonucleotide hybridization.
K-ras oncogene activation in atypical alveolar hyperplasias of the human lung.
K-ras oncogene activation in lung adenocarcinomas from former smokers. Evidence that K-ras mutations are an early and irreversible event in the development of adenocarcinoma of the lung.
K-ras oncogene mutations in sporadic colorectal cancer in The Netherlands Cohort Study.
K-ras oncogene subtype mutations are associated with survival but not expression of p53, p16(INK4A), p21(WAF-1), cyclin D1, erbB-2 and erbB-3 in resected pancreatic ductal adenocarcinoma.
K-ras point mutation detection in lung cancer: comparison of two approaches to somatic mutation detection using ARMS allele-specific amplification.
K-ras point mutation in the nerve plexuses around the superior mesenteric artery in resectable adenocarcinoma of the pancreatic head: distribution pattern and related factors.
K-ras point mutations are rare events in premalignant forms of Barrett's oesophagus.
K-ras point mutations in spontaneously occurring endometrial adenocarcinomas in the Donryu rat.
K-Ras promotes growth transformation and invasion of immortalized human pancreatic cells by Raf and phosphatidylinositol 3-kinase signaling.
K-ras protooncogene mutations in feline pancreatic adenocarcinomas.
Lack of apoptosis in PanIN-1 and PanIN-2 lesions associated with pancreatic ductal adenocarcinoma is not dependent on K-ras status.
Lack of correlation between codon 12 K-ras mutations and major histocompatibility complex antigens in bronchogenic carcinomas.
Lifetime history of alcohol consumption and K-ras mutations in pancreatic ductal adenocarcinoma.
Long-term follow-up of patients with resected pancreatic cancer following vaccination against mutant K-ras.
Low mutational rate of K-ras codon 12 in singular bronchoscopy specimens in suspected lung cancer.
Low Prevalence of K-RAS, EGF-R and BRAF Mutations in Sinonasal Adenocarcinomas. Implications for Anti-EGFR Treatments.
Lung cancer and past occupational exposure to asbestos. Role of p53 and K-ras mutations.
Metabolomic and transcriptomic profiling of human K-ras oncogene transgenic rats with pancreatic ductal adenocarcinomas.
Microadenocarcinoma of the pancreas.
Micropapillary lung adenocarcinoma: EGFR, K-ras, and BRAF mutational profile.
MicroRNAs targeting mutant K-ras by electrotransfer inhibit human colorectal adenocarcinoma cell growth in vitro and in vivo.
Microsatellite instability and K-ras mutations associated with pancreatic adenocarcinoma and pancreatitis.
Microsatellite instability in sporadic and inherited colon adenocarcinomas from Greek patients: correlation with several clinicopathological characteristics.
Mitochondrial catalase suppresses naturally occurring lung cancer in old mice.
Modulation of tumor induction and progression of oncogenic K-ras-positive tumors in the presence of TGF- b1 haploinsufficiency.
Molecular abnormalities in lung cancer.
Molecular analysis of p53 and K-ras in lung carcinomas of coal miners.
Molecular analysis to detect pancreatic ductal adenocarcinoma in high-risk groups.
Molecular assessment of lymph nodes in patients with resected stage I non-small cell lung cancer: preliminary results of a prospective study.
Molecular characteristics of poorly differentiated adenocarcinoma and signet-ring-cell carcinoma of colorectum.
Molecular characterization of adenocarcinoma of the cervix.
Molecular consequences of silencing mutant K-ras in pancreatic cancer cells: justification for K-ras-directed therapy.
Molecular detection of tumor cells in bronchoalveolar lavage fluid from patients with early stage lung cancer.
Molecular diagnosis of exocrine pancreatic cancer using a percutaneous technique.
Molecular diagnosis of pancreatic cancer.
Molecular diagnostic testing as an adjunct to morphologic evaluation of pancreatic ductal system brushings: potential augmentation for diagnostic sensitivity.
Molecular events including p53 and k-ras alterations in the in vitro progression of a human colorectal adenoma cell line to an adenocarcinoma.
Molecular genetic tumor markers in the early diagnosis and screening of non-small-cell lung cancer.
Molecular genetics of exocrine pancreatic neoplasms.
Molecular pathobiology of pancreatic adenocarcinoma.
Molecular pathology of invasive carcinoma.
MSX2 in pancreatic tumor development and its clinical application for the diagnosis of pancreatic ductal adenocarcinoma.
Mucinous and nonmucinous appendiceal adenocarcinomas: different clinicopathological features but similar genetic alterations.
Mucinous bronchioloalveolar carcinoma with K-ras mutation arising in type 1 congenital cystic adenomatoid malformation: a case report with review of the literature.
Mucinous cystic neoplasms of the pancreas: pathology and molecular genetics.
Multiple genetic alterations in hamster pancreatic ductal adenocarcinomas.
Multiple K-ras codon 12 mutations in cholangiocarcinomas demonstrated with a sensitive polymerase chain reaction technique.
Multiplicity of abnormal promoter methylation in lung adenocarcinomas from smokers and never smokers.
Murine lung tumor measurement using respiratory-gated micro-computed tomography.
Mutant KRAS in the initiation of pancreatic cancer.
Mutated Ras peptides as vaccines in immunotherapy of cancer.
Mutation in the K-ras gene at codon 12 does not correlate with disease progression in colorectal carcinoma patients treated with 5-FU/folinic acid biomodulated chemotherapy.
Mutational activation of the K-ras oncogene and the effect of chemotherapy in advanced adenocarcinoma of the lung: a prospective study.
Mutational activation of the K-ras oncogene. A possible pathogenetic factor in adenocarcinoma of the lung.
Mutational analysis of EGFR and K-RAS genes in lung adenocarcinomas.
Mutational and epigenetic evidence for independent pathways for lung adenocarcinomas arising in smokers and never smokers.
Mutations in K-Ras linked to levels of osteoprotegerin and sensitivity to TRAIL-induced cell death in pancreatic ductal adenocarcinoma cells.
Mutations of APC, K-ras, and p53 are associated with specific chromosomal aberrations in colorectal adenocarcinomas.
Mutations of p53 and K-ras genes as prognostic factors for non-small cell lung cancer.
Mutations of the EGFR, K-ras, EML4-ALK, and BRAF genes in resected pathological stage I lung adenocarcinoma.
Mutations of the epidermal growth factor receptor gene in atypical adenomatous hyperplasia and bronchioloalveolar carcinoma of the lung.
Mutations of the K-ras and p53 genes in gastric adenocarcinomas from a high-incidence region around Florence, Italy.
Naturally Occurring T-Cell Response against Mutated p21 Ras Oncoprotein in Pancreatic Cancer.
Negative Control of Cell Migration by Rac1b in Highly Metastatic Pancreatic Cancer Cells Is Mediated by Sequential Induction of Nonactivated Smad3 and Biglycan.
Neurotensin is a versatile modulator of in vitro human Pancreatic Ductal Adenocarcinoma Cell (PDAC) migration.
Neurotensin stimulates protein kinase C-dependent mitogenic signaling in human pancreatic carcinoma cell line PANC-1.
Nicotine-derived N-nitrosamines (TSNA) and their relevance in tobacco carcinogenesis.
Nitrative and oxidative DNA damage caused by K-ras mutation in mice.
Nobiletin, a citrus flavonoid, suppresses invasion and migration involving FAK/PI3K/Akt and small GTPase signals in human gastric adenocarcinoma AGS cells.
Notch1 functions as a tumor suppressor in a model of K-ras-induced pancreatic ductal adenocarcinoma.
Nuclear factor-kappaB (NF-kappaB) is frequently expressed in lung cancer and preneoplastic lesions.
Occurrence of ras mutations in human lung cancer. Minireview.
Oncogenes in cancer of the pancreas.
Oncogenesis and the Clinical Significance of K-ras in Pancreatic Adenocarcinoma.
Oncogenic K-Ras and loss of Smad4 mediate invasion by activating an EGFR/NF-?B Axis that induces expression of MMP9 and uPA in human pancreas progenitor cells.
Oncogenic K-Ras down-regulates Rac1 and RhoA activity and enhances migration and invasion of pancreatic carcinoma cells through activation of p38.
Oncogenic K-ras drives cell cycle progression and phenotypic conversion of primary pancreatic duct epithelial cells.
Oral benzo[a]pyrene-induced cancer: two distinct types in different target organs depend on the mouse Cyp1 genotype.
Outcome of pancreatic cancer patients based on genetic lymph node staging.
p16 and K-ras gene mutations in the intraductal precursors of human pancreatic adenocarcinoma.
p16(INK4a) and histology-specific methylation of CpG islands by exposure to tobacco smoke in non-small cell lung cancer.
p53 and ras gene expression in human esophageal cancer and Barrett's epithelium: a prospective study.
p53 gene mutation and p53 protein overexpression in a patient with simultaneous double cancer of the gallbladder and bile duct associated with pancreaticobiliary maljunction.
Pancreatic adenocarcinomas with DNA replication errors (RER+) are associated with wild-type K-ras and characteristic histopathology. Poor differentiation, a syncytial growth pattern, and pushing borders suggest RER+.
Pancreatic Cancer Signaling Pathways, Genetic Alterations, and Tumor Microenvironment: The Barriers Affecting the Method of Treatment.
Pancreatitis-induced inflammation contributes to pancreatic cancer by inhibiting oncogene-induced senescence.
Past medical conditions and K-ras mutations in pancreatic ductal adenocarcinoma: a hypothesis-generating study.
Pathologic and molecular features of screening low-dose computed tomography (LDCT)-detected lung cancer: a baseline and 2-year repeat study.
Pathology of non-small cell lung cancer. New diagnostic approaches.
Patterns of K-ras codon 12 and 13 mutations found in pancreatic adenocarcinoma of 30 Chinese patients by microdissection, PCR and direct sequencing.
Polymerase chain reaction-based K-ras mutation detection of pancreatic adenocarcinoma in routine cytology smears.
Preconditioning of the tumor microenvironment with oncolytic reovirus converts CD3-bispecific antibody treatment into effective immunotherapy.
Predictive advantage of a cell type classification for pulmonary adenocarcinoma coupled with data for p53, K-ras and EGFR alterations.
Prevalence and clinical significance of combined K-ras mutation and p53 aberration in pancreatic adenocarcinoma.
Prevalence of activating K-ras mutations in the evolutionary stages of neoplasia in intraductal papillary mucinous tumors of the pancreas.
Prevention of lung cancer progression by bexarotene in mouse models.
Primary signet-ring cell carcinoma of the lung: histochemical and immunohistochemical characterization.
Prognostic and predictive value of K-RAS mutations in non-small cell lung cancer.
Prognostic impact of mutated K-ras gene in surgically resected non-small cell lung cancer patients.
Prognostic implications of routine, immunohistochemical, and molecular staging in resectable pancreatic adenocarcinoma.
Prognostic significance of immunohistochemical RhoA expression on survival in pancreatic ductal adenocarcinoma: a high-throughput analysis.
Prognostic significance of K-ras codon 12 mutations in patients with resected stage I and II non-small-cell lung cancer.
Prognostic value of K-RAS mutations in patients with non-small cell lung cancer: a systematic review with meta-analysis.
Prognostic value of K-ras mutations, ras oncoprotein, and c-erb B-2 oncoprotein expression in adenocarcinoma of the lung.
Protein expression of NF-kappaB in human colorectal adenocarcinoma.
Protein farnesyltransferase inhibitors block the growth of ras-dependent tumors in nude mice.
Proteinase-Activated Receptors Differentially Modulate In Vitro Invasion of Human Pancreatic Adenocarcinoma PANC-1 Cells in Correlation With Changes in the Expression of CDC42 Protein.
Pten controls lung morphogenesis, bronchioalveolar stem cells, and onset of lung adenocarcinomas in mice.
Putative contribution of CD56 positive cells in cetuximab treatment efficacy in first-line metastatic colorectal cancer patients.
R-(+)-perillyl alcohol-induced cell cycle changes, altered actin cytoskeleton, and decreased ras and p34(cdc2) expression in colonic adenocarcinoma SW480 cells.
R-Ketorolac Targets Cdc42 and Rac1 and Alters Ovarian Cancer Cell Behaviors Critical for Invasion and Metastasis.
Rab11 in dysplasia of Barrett's epithelia.
Rac1b negatively regulates TGF-?1-induced cell motility in pancreatic ductal epithelial cells by suppressing Smad signalling.
Ran, a small GTPase gene, encodes cytotoxic T lymphocyte (CTL) epitopes capable of inducing HLA-A33-restricted and tumor-reactive CTLs in cancer patients.
Rare occurrence of ras and p53 gene mutations in mouse stomach tumors induced by N-methyl-N-nitrosourea.
Ras activity levels control the development of pancreatic diseases.
ras and myc analysis in primary and metastatic colorectal carcinomas.
Ras gene activation in malignant cells of human ovarian carcinoma peritoneal fluids.
ras gene mutations as a prognostic marker in adenocarcinoma of the human lung without lymph node metastasis.
ras gene mutations in ethmoid sinus adenocarcinoma: prognostic implications.
ras gene mutations in salivary gland tumors.
ras mutation and expression of the ras-regulated genes osteopontin and cathepsin L in human esophageal cancer.
Ras oncogene activation in benign and malignant colorectal tumours.
Ras up-regulation of cyclooxygenase-2.
Ras-driven transformation of human nestin-positive pancreatic epithelial cells.
Reassessment of K-ras mutations at codon 12 by direct PCR and sequencing from tissue microdissection in human pancreatic adenocarcinomas.
Recurrent breast cancer and an adenocarcinoma of the lung occurring in one patient: c-myc oncogene amplification and K-ras codon 12 point mutation as tumour markers.
Reduction of pp32 expression in poorly differentiated pancreatic ductal adenocarcinomas and intraductal papillary mucinous neoplasms with moderate dysplasia.
Relationship between K-ras mutation and the expression of p21WAF1/CIP1 and p53 in chronic pancreatitis and pancreatic adenocarcinoma.
Relationship between K-ras oncogene activation and smoking in adenocarcinoma of the human lung.
Relationship of family cancer history to the expression of p53, p21WAF-1, HER-2/neu, and K-ras mutation in pancreatic adenocarcinoma.
Relationship of Ras association domain family 1 methylation and K-ras mutation in primary non-small cell lung cancer.
Relationships of DNA adduct formation, K-ras activating mutations and tumorigenic activities of 6-nitrochrysene and its metabolites in the lungs of CD-1 mice.
Response to MLN8237 in pancreatic cancer is not dependent on RalA phosphorylation.
Results of a Phase I Trial of 12 Patients With Locally Advanced Pancreatic Carcinoma Combining Gefitinib, Paclitaxel, and 3-Dimensional Conformal Radiation: Report of Toxicity and Evaluation of Circulating K-ras as a Potential Biomarker of Response to Therapy.
Risk for K-ras gene mutations in smoking-induced lung cancer is associated with cytochrome P4501A1 and glutathione S-transferase micro1 polymorphisms.
Role of K-ras and Pten in the development of mouse models of endometriosis and endometrioid ovarian cancer.
Role of point mutation of the K-ras gene in tumorigenesis of B6C3F1 mouse lung lesions induced by urethane.
Role of Rac1 Pathway in Epithelial-to-Mesenchymal Transition and Cancer Stem-like Cell Phenotypes in Gastric Adenocarcinoma.
Role of the alveolar type II cell in the development and progression of pulmonary tumors induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in the A/J mouse.
Role of the DPC4 tumor suppressor gene in adenocarcinoma of the ampulla of Vater: analysis of 140 cases.
Role of the Sec14-like domain of Dbl family exchange factors in the regulation of Rho family GTPases in different subcellular sites.
Runx3 inactivation is a crucial early event in the development of lung adenocarcinoma.
Sex differences in clinicopathological features of peripheral T1 adenocarcinoma of the lung.
Simultaneous mutations in K-ras and TP53 are indicative of poor prognosis in sporadic colorectal cancer.
SKA1 regulates actin cytoskeleton remodelling via activating Cdc42 and influences the migration of pancreatic ductal adenocarcinoma cells.
Small cell carcinoma of the gallbladder: a clinicopathologic, immunohistochemical, and molecular pathology study of 12 cases.
Smoking, oncogenes and human lung cancer. A review of recent laboratory evidence linking smoking and lung cancer.
Solid-pseudopapillary tumors of the pancreas are genetically distinct from pancreatic ductal adenocarcinomas and almost always harbor beta-catenin mutations.
Somatic activation of the K-ras oncogene causes early onset lung cancer in mice.
Somatic mutations of the adenomatous polyposis coli gene in gastroduodenal tumors from patients with familial adenomatous polyposis.
Statins and pancreatic cancer.
STIM1 phosphorylation triggered by epidermal growth factor mediates cell migration.
Studies on clinicopathological features of lung cancer patients with K-ras/p53 gene alterations: comparison between younger and older groups.
Study on association between H-ras gene polymorphism and gastric adenocarcinoma risk.
Superior efficacy of co-treatment with dual PI3K/mTOR inhibitor NVP-BEZ235 and pan-histone deacetylase inhibitor against human pancreatic cancer.
Survey of ferns and clinico-pathological studies on the field cases of Enzootic bovine haematuria in Himachal Pradesh, a north-western Himalayan state of India.
Survival after surgical management of pancreatic adenocarcinoma: does curative and radical surgery truly exist?
Synergistic effects of sorafenib in combination with gemcitabine or pemetrexed in lung cancer cell lines with K-ras mutations.
T1, an immunoglobulin superfamily member, is expressed in H-ras-dependent epithelial tumours of mammary cells.
Targeting Endogenous K-RAS for Degradation through the Affinity-Directed Protein Missile System.
Targeting Mutated K-ras in Pancreatic Adenocarcinoma Using an Adjuvant Vaccine.
Targeting phosphoinositide 3-kinase pathways in pancreatic cancer--from molecular signalling to clinical trials.
Targeting Rho GTPase effector p21 activated kinase 4 (PAK4) suppresses p-Bad-microRNA drug resistance axis leading to inhibition of pancreatic ductal adenocarcinoma proliferation.
The cell of origin and subtype of K-Ras-induced lung tumors are modified by Notch and Sox2.
The clinical significance of K-ras mutation in endometrial "surface epithelial changes" and their associated endometrial adenocarcinoma.
The combination of everolimus and zoledronic acid increase the efficacy of gemcitabine in a mouse model of pancreatic adenocarcinoma.
The cornerstone K-RAS mutation in pancreatic adenocarcinoma: From cell signaling network, target genes, biological processes to therapeutic targeting.
The genetics of pancreatic cancer.
The K-ras mutation pattern in pancreatic ductal adenocarcinoma usually is identical to that in associated normal, hyperplastic, and metaplastic ductal epithelium.
The mutant K-ras oncogene causes pancreatic periductal lymphocytic infiltration and gastric mucous neck cell hyperplasia in transgenic mice.
The mutations of the EGFR and K-ras genes in resected stage I lung adenocarcinoma and their clinical significance.
The oncogenic kinase Pim-1 is modulated by K-Ras signaling and mediates transformed growth and radioresistance in human pancreatic ductal adenocarcinoma cells.
The pattern of K-ras mutation in pulmonary adenocarcinoma defines a new pathway of tumour development in the human lung.
The presence of K-12 ras mutations in duodenal adenocarcinomas and the absence of ras mutations in other small bowel adenocarcinomas and carcinoid tumors.
The prognostic significance of K-ras, p53, and APC mutations in colorectal carcinoma.
The prognostic significance of tumor-associated markers p53, HER-2/neu, c-myc, v-H-ras, PCNA and EGFr of local and distant recurrence in localized human prostatic adenocarcinoma.
The ras gene family in human non-small-cell lung cancer.
The ras oncogenes in human lung cancer.
The relationship between microvessel count and the expression of vascular endothelial growth factor, p53, and K-ras in non-small cell lung cancer.
The retinoblastoma gene Rb and its family member p130 suppress lung adenocarcinoma induced by oncogenic K-Ras.
The role of K-ras gene mutation analysis in EUS-guided FNA cytology specimens for the differential diagnosis of pancreatic solid masses: a meta-analysis of prospective studies.
The sequential accumulation of genetic alterations characteristic of the colorectal adenoma-carcinoma sequence does not occur between gastric adenoma and adenocarcinoma.
The utility of cytology in the diagnosis of adenocarcinoma lung: A tertiary care center study.
Tissue Transglutaminase (TG2)-Induced Inflammation in Initiation, Progression, and Pathogenesis of Pancreatic Cancer.
TP53, p14ARF, p16INK4a and H-ras gene molecular analysis in intestinal-type adenocarcinoma of the nasal cavity and paranasal sinuses.
Tumor angiogenesis in chronic pancreatitis and pancreatic adenocarcinoma: impact of K-ras mutations.
Tumor suppressive role of miR-33a-5p in pancreatic ductal adenocarcinoma cells by directly targeting RAP2A.
Tumor-suppressive pathways in pancreatic carcinoma.
Unique K-ras mutational pattern in pancreatic adenocarcinoma from Taiwanese patients.
Update on phase I studies in advanced pancreatic adenocarcinoma. Hunting in darkness?
Usufuleness of p16 and K-ras mutation in pancreatic adenocarcinoma and chronic pancreatitis differential diagnosis.
Vaccination with mutant ras peptides and induction of T-cell responsiveness in pancreatic carcinoma patients carrying the corresponding RAS mutation.
Validation of the Point-EXACCT method in non-small cell lung carcinomas.
Vascular endothelial growth factor and nitric oxide synthase expression in human lung cancer and the relation to p53.
Vav1 and mutant K-Ras synergize in the early development of pancreatic ductal adenocarcinoma in mice.
VEGF neutralizing aerosol therapy in primary pulmonary adenocarcinoma with K-ras activating-mutations.
Villous, hypermucinous mucosa in long standing ulcerative colitis shows high frequency of K-ras mutations.
[A resected case of metastatic pancreatic cancer from cecal carcinoma]
[Activation of K-ras and c-erbB-2 protooncogenes in human colonic adenocarcinomas]
[Adenocarcinoma of the pancreas. General characteristics]
[Analysis of K-ras, BRCA1/2, CHEK2 mutations and microsatellite markers (loss of heterozygosity at 9p, 17p and 18q) in sporadic pancreas adenocarcinomas]
[Demonstration of molecular forms of Rap 1 in cells or tissues deriving from normal or pathological human colonic epithelium]
[Detection of K-ras mutation from malignant cells in sputum with mutant-allele specific amplification (MASA) method]
[Detection of K-ras oncogene activation in human lung cancer and its possible clinical application]
[Detection of micrometastases after curative resection for ductal adenocarcinoma of the pancreas]
[Expression and mutation of p53 and H-ras genes in the carcinogenesis and development of gastric adenocarcinoma induced by MNNG in rats]
[Gene K-ras mutation in cells of endometrial adenocarcinoma in women]
[General rules for the study of pancreatic cancer by molecular biological aspect]
[Genes, heredity and colorectal cancer]
[Genetic heterogeneity of certain sporadic colorectal cancers]
[Mechanisms of action of targeted therapies... and mechanisms of resistance]
[Molecular diagnosis in pancreatic carcinoma]
[Morphology as the starting point for individualized cancer treatment]
[Mutation analysis of K-ras protooncogene in colorectal adenocarcinomas and polyps in Russian patients]
[Mutational analysis of EGFR and K-RAS in Chinese patients with non-small cell lung cancer]
[Reversal of pulmonary hypertrophic osteoarthropathy in surgically treated lung cancer].
[Study on the mutations of p53 and K-ras gene in the cancer tissues and sputum cells of patients with lung cancer.]
[The Expression of COX-2 in Human Lung Cancer and its Relationship with Expression of K-ras and Mcl-1.]
Adenocarcinoma of Lung
5-Aza-2'-deoxycytidine is chemopreventive in a 4-(methyl-nitrosamino)-1-(3-pyridyl)-1-butanone-induced primary mouse lung tumor model.
A central role for Foxp3+ regulatory T cells in K-Ras-driven lung tumorigenesis.
A genetic mouse model for metastatic lung cancer with gender differences in survival.
A selective small molecule inhibitor of c-Met, PHA-665752, reverses lung premalignancy induced by mutant K-ras.
A subset of lung adenocarcinomas and atypical adenomatous hyperplasia-associated foci are genotypically related: an EGFR, HER2, and K-ras mutational analysis.
Activation of K-ras in aflatoxin B1-induced lung tumors from AC3F1 (A/J x C3H/HeJ) mice.
Activation of proto-oncogenes in human and mouse lung tumors.
Allele-specific detection of K-ras oncogene expression in human non-small-cell lung carcinomas.
Alterations of K-ras, p53, and erbB-2/neu in human lung adenocarcinomas.
Analysis of K-ras gene mutations in lung carcinomas: correlation with gender, histological subtypes, and clinical outcome.
Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras.
Analysis of the role of DAMTC in lung adenocarcinoma cells based on the DNA microarrays.
Chromosomal alterations in lung adenocarcinoma from smokers and nonsmokers.
Cigarette smoking and K-ras mutations in pancreas, lung and colorectal adenocarcinomas: Etiopathogenic similarities, differences and paradoxes.
Cigarette smoking is strongly associated with mutation of the K-ras gene in patients with primary adenocarcinoma of the lung.
CK20 expression, CDX2 expression, K-ras mutation, and goblet cell morphology in a subset of lung adenocarcinomas.
Clinicopathological and prognostic features of surgically resected pathological stage I lung adenocarcinoma harboring epidermal growth factor receptor and K-ras mutation.
Clinicopathological significance of epigenetic inactivation of RASSF1A at 3p21.3 in stage I lung adenocarcinoma.
Clonality status of multifocal lung adenocarcinomas based on the mutation patterns of EGFR and K-ras.
Combined Inactivation of MYC and K-Ras oncogenes reverses tumorigenesis in lung adenocarcinomas and lymphomas.
Combining an FPTase inhibitor with cisplatin facilitates induction of apoptosis in human A549 lung cancer cells.
Comprehensive molecular analyses of lung adenocarcinoma with regard to the epidermal growth factor receptor, K-ras, MET, and hepatocyte growth factor status.
Computed tomographic images reflect the biologic behavior of small lung adenocarcinoma: they correlate with cell proliferation, microvascularization, cell adhesion, degradation of extracellular matrix, and K-ras mutation.
Contextual extracellular cues promote tumor cell EMT and metastasis by regulating miR-200 family expression.
Cytochrome c oxidase is activated by the oncoprotein Ras and is required for A549 lung adenocarcinoma growth.
Decrease in K-ras p21 and increase in Raf1 and activated Erk 1 and 2 in murine lung tumors initiated by N-nitrosodimethylamine and promoted by 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Deletion of cyclooxygenase-2 inhibits K-ras-induced lung carcinogenesis.
Detection of codon 12 K-ras mutations in non-neoplastic mucosa from bronchial carina in patients with lung adenocarcinomas.
Detection of codon 12 point mutations of the K-ras gene from mouse lung adenocarcinoma by 'enriched' PCR.
Detection of EGFR and K-ras mutations for diagnosis of multiple lung adenocarcinomas.
Detection of K-ras mutations of bronchoalveolar lavage fluid cells aids the diagnosis of lung cancer in small pulmonary lesions.
Detection of K-ras oncogene mutations in bronchoalveolar lavage fluid for lung cancer diagnosis.
Detection of k-ras point mutations in codons 12 and 13 in non-small cell lung cancers.
Development of a rapid and practical mutation screening assay for human lung adenocarcinoma.
Differential response to 1?,25-dihydroxyvitamin D(3) (1?,25(OH)(2)D(3)) in non-small cell lung cancer cells with distinct oncogene mutations.
Discordance of Mutation Statuses of Epidermal Growth Factor Receptor and K-ras between Primary Adenocarcinoma of Lung and Brain Metastasis.
Distinctive evaluation of nonmucinous and mucinous subtypes of bronchioloalveolar carcinomas in EGFR and K-ras gene-mutation analyses for Japanese lung adenocarcinomas: confirmation of the correlations with histologic subtypes and gene mutations.
DNA damage, superoxide, and mutant K-ras in human lung adenocarcinoma cells.
Effects of perillyl alcohol and heat shock treatment in gene expression of human lung adenocarcinoma cell line A549.
EGFR and K-Ras mutations in women with lung adenocarcinoma: implications for treatment strategy definition.
EGFR mutations in non-small-cell lung cancer: analysis of a large series of cases and development of a rapid and sensitive method for diagnostic screening with potential implications on pharmacologic treatment.
EphA2 in the early pathogenesis and progression of non-small cell lung cancer.
Epidermal growth factor receptor and K-Ras in non-small cell lung cancer-molecular pathways involved and targeted therapies.
Epidermal growth factor receptor and K-RAS mutations in 411 lung adenocarcinoma: a population-based prospective study.
Epidermal growth factor receptor gene mutations in atypical adenomatous hyperplasias of the lung.
Epidermal growth factor receptor mutations and anaplastic lymphoma kinase rearrangements in lung cancer with nodular ground-glass opacity.
Expression of TLR9 in tumor-infiltrating mononuclear cells enhances angiogenesis and is associated with a worse survival in lung cancer.
Favorable response to erlotinib in a lung adenocarcinoma with both epidermal growth factor receptor exon 19 deletion and K-ras G13D mutations.
FHIT and p53 gene abnormalities in bronchioloalveolar carcinomas. Correlations with clinicopathological data and K-ras mutations.
Fibulin-2 is a driver of malignant progression in lung adenocarcinoma.
Flavonol isolated from ethanolic leaf extract of Thuja occidentalis arrests the cell cycle at G2-M and induces ROS-independent apoptosis in A549 cells, targeting nuclear DNA.
Foxm1 transcription factor is required for the initiation of lung tumorigenesis by oncogenic Kras(G12D.)
Genetic analysis of lung tumours of non-smoking subjects: p53 gene mutations are constantly associated with loss of heterozygosity at the FHIT locus.
Genetically Engineered Mouse Models of K-Ras-Driven Lung and Pancreatic Tumors: Validation of Therapeutic Targets.
Glutathione S-transferase mu1 null genotype is associated with K-ras gene mutation in lung adenocarcinoma among smokers.
High-LET Radiation Increases Tumor Progression in a K-Ras-Driven Model of Lung Adenocarcinoma.
Hyperglycemia promotes K-Ras-induced lung tumorigenesis through BASCs amplification.
Identification of cancer initiating cells in K-Ras driven lung adenocarcinoma.
Identification of secreted proteins that mediate cell-cell interactions in an in vitro model of the lung cancer microenvironment.
Incidence and possible clinical significance of K-ras oncogene activation in adenocarcinoma of the human lung.
Increased K-ras protein and activity in mouse and human lung epithelial cells at confluence.
Increased prevalence of K-ras oncogene mutations in lung adenocarcinoma.
Induction and apoptotic regression of lung adenocarcinomas by regulation of a K-Ras transgene in the presence and absence of tumor suppressor genes.
Inhibition of lung tumor cell growth in vitro and mouse lung tumor formation by lovastatin.
Inhibition of mammalian target of rapamycin reverses alveolar epithelial neoplasia induced by oncogenic K-ras.
Inhibition of the prenylation of K-Ras, but not H- or N-Ras, is highly resistant to CAAX peptidomimetics and requires both a farnesyltransferase and a geranylgeranyltransferase I inhibitor in human tumor cell lines.
Integrating RAS Status into Prognostic Signatures for Adenocarcinomas of the Lung.
Interaction between smoking and asbestos in human lung adenocarcinoma: role of K-ras mutations.
Interplay between estrogen and Stat3/NF-?B-driven immunomodulation in lung cancer.
Interplay between menin and K-Ras in regulating lung adenocarcinoma.
JAK-STAT inhibition impairs K-RAS-driven lung adenocarcinoma progression.
K-ras 4A and 4B mRNA levels correlate with superoxide in lung adenocarcinoma cells, while at the protein level, only mutant K-ras 4A protein correlates with superoxide.
K-ras activation generates an inflammatory response in lung tumors.
K-ras gene mutation enhances motility of immortalized airway cells and lung adenocarcinoma cells via Akt activation: possible contribution to non-invasive expansion of lung adenocarcinoma.
K-ras gene mutation in sputum samples containing atypical cells and adenocarcinoma cells in the lung.
K-ras gene mutations: an unfavorable prognostic marker in stage I lung adenocarcinoma.
k-ras mutation and occupational asbestos exposure in lung adenocarcinoma: asbestos-related cancer without asbestosis.
K-ras mutations in human adenocarcinoma of the lung: association with smoking and occupational exposure to asbestos.
K-ras mutations in mouse lung tumors of extreme age: independent of paternal preconceptional exposure to chromium(III) but significantly more frequent in carcinomas than adenomas.
K-Ras Mutations in Non-Small-Cell Lung Cancer: Prognostic and Predictive Value.
K-ras oncogene activation as a prognostic marker in adenocarcinoma of the lung.
K-ras oncogene activation in atypical alveolar hyperplasias of the human lung.
K-ras oncogene activation in lung adenocarcinomas from former smokers. Evidence that K-ras mutations are an early and irreversible event in the development of adenocarcinoma of the lung.
K-ras p21 expression and activity in lung and lung tumors.
K-Ras-Activated Cells Can Develop into Lung Tumors When Runx3-Mediated Tumor Suppressor Pathways Are Abrogated.
K-rasG12V mediated lung tumor models identified three new quantitative trait loci modifying events post-K-ras mutation.
KIF5B-RET Fusion gene may coincide oncogenic mutations of EGFR or KRAS gene in lung adenocarcinomas.
KRAS mutant NSCLC, a new opportunity for the synthetic lethality therapeutic approach.
Levels and membrane localization of the c-K-ras p21 protein in lungs of mice of different genetic strains and effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and Aroclor 1254.
Micropapillary lung adenocarcinoma: EGFR, K-ras, and BRAF mutational profile.
MicroRNA-149 inhibits the progression of lung adenocarcinoma through targeting RAP1B and inactivating Wnt/?-catenin pathway.
Microsatellite and EGFR, HER2 and K-RAS analyses in sclerosing hemangioma of the lung.
miRNA-34 prevents cancer initiation and progression in a therapeutically-resistant K-ras and p53-induced mouse model of lung adenocarcinoma.
Modulation of tumor induction and progression of oncogenic K-ras-positive tumors in the presence of TGF- b1 haploinsufficiency.
Multiple cells-of-origin of mutant K-Ras-induced mouse lung adenocarcinoma.
Mutant K-rasV12 increases COX-2, peroxides and DNA damage in lung cells.
Mutational analysis of AKT1, AKT2 and AKT3 genes in common human carcinomas.
Mutational analysis of EGFR and K-RAS genes in lung adenocarcinomas.
Mutations of K-ras oncogene and absence of H-ras mutations in squamous cell carcinomas of the lung.
Mutations of the EGFR, K-ras, EML4-ALK, and BRAF genes in resected pathological stage I lung adenocarcinoma.
Nicotine does not enhance tumorigenesis in mutant K-ras-driven mouse models of lung cancer.
Novel ternary vanadium-betaine-peroxido species suppresses H-ras and matrix metalloproteinase-2 expression by increasing reactive oxygen species-mediated apoptosis in cancer cells.
Nullifying the CDKN2A/B Locus Promotes Mutant K-ras Lung Tumorigenesis.
Occurrence of ras mutations in human lung cancer. Minireview.
Oncogenic RIT1 mutations in lung adenocarcinoma.
Overexpression of RhoV Promotes the Progression and EGFR-TKI Resistance of Lung Adenocarcinoma.
Overexpression of the p53 tumor suppressor gene product in primary lung adenocarcinomas is associated with cigarette smoking.
p38? negatively regulates survival and malignant selection of transformed bronchioalveolar stem cells.
p53 and K-ras in radon-associated lung adenocarcinoma.
Phosphatidylinositol 3-kinase mediates bronchioalveolar stem cell expansion in mouse models of oncogenic K-ras-induced lung cancer.
Prognostic impact of mutated K-ras gene in surgically resected non-small cell lung cancer patients.
Rab27A regulates exosome secretion from lung adenocarcinoma cells A549: involvement of EPI64.
Rab27b Is a Potential Indicator for Lymph Node Metastasis and Unfavorable Prognosis in Lung Adenocarcinoma.
Rac1 targeting suppresses human non-small cell lung adenocarcinoma cancer stem cell activity.
Ras oncogene point mutation: an infrequent event in bronchioloalveolar cancer.
RAS-MAPK dependence underlies a rational polytherapy strategy in EML4-ALK-positive lung cancer.
Reduced NF1 expression confers resistance to EGFR inhibition in lung cancer.
Relationship between K-ras oncogene activation and smoking in adenocarcinoma of the human lung.
Risk for K-ras gene mutations in smoking-induced lung cancer is associated with cytochrome P4501A1 and glutathione S-transferase micro1 polymorphisms.
Runx3 inactivation is a crucial early event in the development of lung adenocarcinoma.
Runx3 is required for the differentiation of lung epithelial cells and suppression of lung cancer.
Sex specific function of epithelial STAT3 signaling in pathogenesis of K-ras mutant lung cancer.
Silenced Expression of NFKBIA in Lung Adenocarcinoma Patients with a Never-smoking History.
Sirt1 protects from K-Ras-driven lung carcinogenesis.
Somatic mutations of ERBB2 kinase domain in gastric, colorectal, and breast carcinomas.
Synergistic cell growth inhibition by the combination of amrubicin and Akt-suppressing agents in K-ras mutation-harboring lung adenocarcinoma cells: implication of EGFR tyrosine kinase inhibitors.
Synthesis and evaluation of bis-thiazole derivatives as new anticancer agents.
The differential effects of mutant p53 alleles on advanced murine lung cancer.
The Human Immunodeficiency Virus Protease Inhibitor Ritonavir Inhibits Lung Cancer Cells, in Part, by Inhibition of Survivin.
The LIM-domain only protein 4 contributes to lung epithelial cell proliferation but is not essential for tumor progression.
The Long Intergenic Noncoding RNA 00707 Promotes Lung Adenocarcinoma Cell Proliferation and Migration by Regulating Cdc42.
The mutations of the EGFR and K-ras genes in resected stage I lung adenocarcinoma and their clinical significance.
The Ras-related protein AGS1/RASD1 suppresses cell growth.
The retinoblastoma gene Rb and its family member p130 suppress lung adenocarcinoma induced by oncogenic K-Ras.
ZEB1 drives prometastatic actin cytoskeletal remodeling by downregulating miR-34a expression.
[CRAF, a key player in lung adenocarcinomas induced by K-Ras oncogene].
[Detection of ALK positive pulmonary adenocarcinoma using immunostaining].
[Detection of K-ras oncogene activation in human lung cancer and its possible clinical application]
[Impact of prenylation inhibition on RAS mutant tumors in preclinical studies].
[KRAS and bronchial adenocarcinoma. Between disappointments and hopes].
[Synchronous Multiple Primary Lung Cancer Dignosed ?by Different Phenotype-genotype: A Case Report and Literature Review].
Adenocarcinoma, Bronchiolo-Alveolar
Distinctive evaluation of nonmucinous and mucinous subtypes of bronchioloalveolar carcinomas in EGFR and K-ras gene-mutation analyses for Japanese lung adenocarcinomas: confirmation of the correlations with histologic subtypes and gene mutations.
FHIT and p53 gene abnormalities in bronchioloalveolar carcinomas. Correlations with clinicopathological data and K-ras mutations.
Growth regulation via insulin-like growth factor binding protein-4 and -2 in association with mutant K-ras in lung epithelia.
Map kinase activation correlates with K-ras mutation and loss of heterozygosity on chromosome 6 in alveolar bronchiolar carcinomas from B6C3F1 mice exposed to vanadium pentoxide for 2 years.
Microsatellite and EGFR, HER2 and K-RAS analyses in sclerosing hemangioma of the lung.
Mucinous bronchioloalveolar carcinoma with K-ras mutation arising in type 1 congenital cystic adenomatoid malformation: a case report with review of the literature.
Adenocarcinoma, Clear Cell
Investigation of c-myc and K-ras amplification in renal clear cell adenocarcinoma.
Adenocarcinoma, Follicular
A molecular expression signature distinguishing follicular lesions in thyroid carcinoma using preamplification RT-PCR in archival samples.
Memory T cells of a patient with follicular thyroid carcinoma recognize peptides derived from mutated p21 ras (Gln-->Leu61).
Adenocarcinoma, Mucinous
Alteration of the p53 tumor suppressor gene occurs independently of K-ras activation and more frequently in serous adenocarcinomas than in other common epithelial tumors of the human ovary.
Analysis of clonality by amplification of short tandem repeats. Carcinomas of the female reproductive tract.
Characteristics in primary signet-ring cell carcinoma of the colorectum, from clinicopathological observations.
Clinicopathological and genetic characteristics of mucinous carcinomas in the colorectum.
Direct Correlation Between Double K-RAS Mutation and Mucinous Carcinoma. A Case Report.
Gene-environment interactions in the pre-Industrial Era: the cancer of King Ferrante I of Aragon (1431-1494).
Heterogeneous distribution of K-ras-mutated epithelia in mucinous ovarian tumors with special reference to histopathology.
Immunohistochemical studies of colorectal cancers that developed following pelvic irradiation.
K-ras activation in neoplasms of the human female reproductive tract.
K-ras activation occurs frequently in mucinous adenocarcinomas and rarely in other common epithelial tumors of the human ovary.
Mucinous adenocarcinoma arising from supratentorial intramedullary neuroenteric cyst with broncho-pulmonary differentiation.
Mucinous adenocarcinoma with lepidic pattern and with K-RAS mutation in a newborn with antenatal diagnosis of congenital pulmonary airway malformation.
Mucinous carcinomas of the colorectum have distinct molecular genetic characteristics.
Ovarian mucinous tumor with malignant mural nodules: dedifferentiation or collision?
P53 mutation but not p16/MTS1 mutation occurs in intraductal papillary mucinous tumors of the pancreas.
Adenocarcinoma, Papillary
A repeated pancreatectomy in the remnant pancreas 22 months after pylorus-preserving pancreatoduodenectomy for pancreatic adenocarcinoma.
K-ras gene mutations in intrahepatic bile duct tumors of Syrian golden hamsters.
[Detection of point mutation of Kirsten ras oncogene in pancreatic carcinoma by polymerase chain reaction]
Adenoma
A 0.8-mm depressed adenoma of the colon with high-grade dysplasia.
A case of colorectal carcinoma in adenoma analyzed by a cDNA array.
A case of small pancreatic cancer diagnosed by serial follow-up studies promptly by a positive K-ras point mutation in pure pancreatic juice.
A detailed analysis of K-ras point mutations in relation to tumor progression and survival in colorectal cancer patients.
A detailed analysis of the role of K-ras gene mutation in the progression of colorectal adenoma.
A germ-line p53 mutation accelerates pulmonary tumorigenesis: p53-independent efficacy of chemopreventive agents green tea or dexamethasone/myo-inositol and chemotherapeutic agents taxol or adriamycin.
A molecular expression signature distinguishing follicular lesions in thyroid carcinoma using preamplification RT-PCR in archival samples.
A possible multiclonal development in human colonic carcinomas.
A rapid PCR ELISA for the detection of activated K-ras in colorectal cancer.
A very large villous adenoma with an adjacent cancer of the rectum: an informative case for testing the proposed molecular basis of colorectal tumorigenesis.
Absent ras gene mutations in human adrenal cortical neoplasms and pheochromocytomas.
ACB-PCR quantification of K-RAS codon 12 GAT and GTT mutant fraction in colon tumor and non-tumor tissue.
Activation of H-ras is prevalent in 1,3-butadiene-induced and spontaneously occurring murine Harderian gland tumors.
Activation of protooncogenes in spontaneously occurring non-liver tumors from C57BL/6 x C3H F1 mice.
Activation of the K-ras oncogene in colorectal neoplasms is associated with decreased apoptosis.
Activation of the ras genes in malignant and premalignant colorectal tumors.
Activator protein-1 activity regulates epithelial tumor cell identity.
Additional evidence that the K-ras protooncogene is a candidate for the major mouse pulmonary adenoma susceptibility (Pas-1) gene.
Adenoma-carcinoma sequence of colorectum. Prevalence of K-ras gene mutation in adenomas with increasing degree of dysplasia and aneuploidy.
Altered expression of beta-catenin, inducible nitric oxide synthase and cyclooxygenase-2 in azoxymethane-induced rat colon carcinogenesis.
Alternative splicing of TIA-1 in human colon cancer regulates VEGF isoform expression, angiogenesis, tumour growth and bevacizumab resistance.
Analysis of K-ras codon 12 mutation in flat and nodular variants of serrated adenoma in the colon.
Analysis of K-ras, APC, and beta-catenin in aberrant crypt foci in sporadic adenoma, cancer, and familial adenomatous polyposis.
Analysis of somatic molecular changes, clinicopathological features, family history, and germline mutations in colorectal cancer families: evidence for efficient diagnosis of HNPCC and for the existence of distinct groups of non-HNPCC families.
Analysis of the genetic alterations in a case of juvenile multiple colon carcinoma with hypogammaglobulinemia.
Aneuploidy mechanisms in human colorectal preneoplastic lesions and Barrett's esophagus. Is there a role for K-ras and p53 mutations?
APC and K-ras gene mutation in aberrant crypt foci of human colon.
APC mutations are sufficient for the growth of early colorectal adenomas.
APC, K-ras codon 12 mutations and p53 gene expression in carcinoma and adenoma of the gall-bladder suggest two genetic pathways in gall-bladder carcinogenesis.
Association of K-ras mutations with p16 methylation in human colon cancer.
BRAF, K-ras and BAT26 mutations in colorectal polyps and stool.
c-Ki-ras point mutations in ductectatic-type mucinous cystic neoplasms of the pancreas.
CD44 expression in colorectal adenomas is an early event occurring prior to K-ras and p53 gene mutation.
Cell surface overexpression of galectin-3 and the presence of its ligand 90k in the blood plasma as determinants in colon neoplastic lesions.
Cigarette smoking and K-ras mutations in pancreas, lung and colorectal adenocarcinomas: Etiopathogenic similarities, differences and paradoxes.
Classification of advanced colorectal carcinomas by tumor edge morphology: evidence for different pathogenesis and significance of polypoid and nonpolypoid tumors.
Colorectal adenoma progression and genetic change: is there a link?
Colorectal adenoma to carcinoma progression follows multiple pathways of chromosomal instability.
Colorectal cancer screening by detection of altered human DNA in stool: feasibility of a multitarget assay panel.
Comparative molecular pathology of sporadic hyperplastic polyps and neoplastic lesions from the same individual.
Comparison of epigenetic and genetic alterations in mucinous cystic neoplasm and serous microcystic adenoma of pancreas.
Concordant CpG island methylation in hyperplastic polyposis.
Conditional expression of mutated K-ras accelerates intestinal tumorigenesis in Msh2-deficient mice.
Correlation between hypermethylation of the RASSF2A promoter and K-ras/BRAF mutations in microsatellite-stable colorectal cancers.
Cronkhite-Canada syndrome containing colon cancer and serrated adenoma lesions.
Detailed analysis of genetic alterations in colorectal tumors from patients with and without familial adenomatous polyposis (FAP).
Detection of colorectal cancer K-ras mutations using a simplified oligonucleotide ligation assay.
Detection of genetic abnormalities in neoplasms from Greek patients with FAP.
Detection of genetic alterations in the p53 suppressor gene and the K-ras oncogene among different grades of dysplasia in patients with colorectal adenomas.
Detection of K-ras gene mutations at codon 12 in the pancreatic juice of patients with intraductal papillary mucinous tumors of the pancreas.
Detection of k-ras mutation in normal and malignant colonic tissues by an enriched PCR method.
Detection of K-ras mutations in DNAs isolated from feces of patients with colorectal tumors by mutant-allele-specific amplification (MASA).
Detection of somatic DNA alterations in azoxymethane-induced F344 rat colon tumors by random amplified polymorphic DNA analysis.
Detection of up to 65% of Precancerous Lesions of the Human Colon and Rectum by Mutation Analysis of APC, K-Ras, B-Raf and CTNNB1.
Diet, lifestyle and risk of K-ras mutation-positive and -negative colorectal adenomas.
Dietary, lifestyle and clinicopathological factors associated with BRAF and K-ras mutations arising in distinct subsets of colorectal cancers in the EPIC Norfolk study.
Differences in mucus and K-ras mutation in relation to phenotypes of tumors of the papilla of vater.
Differential sensitivity of human colonic adenoma and carcinoma cells to transforming growth factor beta (TGF-beta): conversion of an adenoma cell line to a tumorigenic phenotype is accompanied by a reduced response to the inhibitory effects of TGF-beta.
Differentially expressed genes associated with mouse lung tumor progression.
Disseminated colorectal tumor cells in organs prone to metastasis detected by new double enriched nested-PCR in comparison with recognized assays.
Distinct genetic profiles in colorectal tumors with or without the CpG island methylator phenotype.
Effect of K-ras mutation on morphogenesis of colorectal adenomas and early cancers: relationship to distribution of proliferating cells.
Effects of K-ras gene mutations in the development of lung lesions induced by 4-(N-methyl-n-nitrosamino)-1-(3-pyridyl)-1-butanone in A/J mice.
Effects of vitamin D in lung, stomach, esophagus and testis tissues following administration of urethane in balb/c mice.
Expression of human Krev-1 gene in lungs of transgenic mice and subsequent reduction in multiplicity of ethyl carbamate-induced lung adenomas.
Expression of p21ras-related protein in the plasma and tissue of patients with adenomas and carcinomas of the colon.
Expression of the glucocorticoid receptor and K-ras genes in urethan-induced mouse lung tumors and transformed cell lines.
Flat-elevated and depressed, subtypes of flat early colorectal cancers, should be distinguished by their pathological features.
Frequent altered expression of fragile histidine triad protein in human colorectal adenomas.
From colonic polyps to colon cancer: pathophysiology, clinical presentation, screening and colonoscopic therapy.
Gallbladder adenomas have molecular abnormalities different from those present in gallbladder carcinomas.
Gene alterations in intestinal metaplasia and gastric cancer.
Gene mutations of K-ras in gallbladder mucosae and gallbladder carcinoma with an anomalous junction of the pancreaticobiliary duct.
Genetic alterations in gallbladder adenoma, dysplasia and carcinoma.
Genetic alterations in gastric adenomas of intestinal and foveolar phenotypes.
Genetic alterations in mouse lung tumors: implications for cancer chemoprevention.
Genetic alterations in ovarian carcinoma: with specific reference to histological subtypes.
Genetic alterations in serrated adenomas: comparison to conventional adenomas and hyperplastic polyps.
Genetic alterations in the 61st codon of the H-ras oncogene isolated from archival sections of hepatic hyperplasias, adenomas and carcinomas in control groups of B6C3F1 mouse bioassay studies conducted from 1979 to 1986.
Genetic alterations of mixed hyperplastic adenomatous polyps in the colon and rectum.
Genetic and protein markers related to in situ growth and multiplicity in small sporadic colorectal adenomas.
Genetic changes and histopathological types in colorectal tumors from patients with familial adenomatous polyposis.
Genetic changes in multi-step development of colorectal cancer.
Genetic epidemiology of mutated K-ras proto-oncogene, altered suppressor genes, and microsatellite instability in colorectal adenomas.
Genetic events in sporadic colorectal adenomas: K-ras and p53 heterozygous mutations are not sufficient for malignant progression.
Genetic heterogeneity in sporadic colorectal adenomas.
Genetic pathways in the evolution of morphologically distinct colorectal neoplasms.
Germline and somatic mutations in exon 15 of the APC gene and K-ras mutations in duodenal adenomas in patients with familial adenomatous polyposis.
Glutathione S-transferase-pi overexpression is closely associated with K-ras mutation during human colon carcinogenesis.
H-RAS 81 polymorphism is significantly associated with aneuploidy in follicular tumors of the thyroid.
H-ras mutations in human pituitary carcinoma metastases.
H-ras protooncogene mutations in human thyroid neoplasms.
Hepatocarcinogenicity of chlordane in B6C3F1 and B6D2F1 male mice: evidence for regression in B6C3F1 mice and carcinogenesis independent of ras proto-oncogene activation.
High frequency of K-ras mutations in human colorectal hyperplastic polyps.
High frequency of K-ras mutations in spontaneous and vinyl carbamate-induced lung tumors of relatively resistant B6CF1 (C57BL/6J x BALB/cJ) mice.
High frequency of K-ras mutations in sporadic colorectal adenomas.
High frequency of ras mutations in forestomach and lung tumors of B6C3F1 mice exposed to 1-amino-2,4-dibromoanthraquinone for 2 years.
High prevalence of sessile serrated adenomas with BRAF mutations: a prospective study of patients undergoing colonoscopy.
Histological and genetic changes in malignant transformation of gallbladder adenoma.
Human colorectal mucosal O6-alkylguanine DNA-alkyltransferase activity and DNA-N7-methylguanine levels in colorectal adenoma cases and matched referents.
Hypermethylation of the Ras association domain family 1A (RASSF1A) gene in gallbladder cancer.
Hyperplastic polyps and sessile serrated adenomas as a phenotypic expression of MYH-associated polyposis.
Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is associated with G to A mutations in K-ras in colorectal tumorigenesis.
Increased frequency of the k-ras G12C mutation in MYH polyposis colorectal adenomas.
Infrequent activation of K-ras, H-ras, and other oncogenes in hepatocellular neoplasms initiated by methyl(acetoxymethyl)nitrosamine, a methylating agent, and promoted by phenobarbital in F344 rats.
Infrequent K-ras activation in superficial-type (flat) colorectal adenomas and adenocarcinomas.
Infrequent K-ras codon 12 mutation in serrated adenomas of human colorectum.
Intraductal papillary-mucinous tumours represent a distinct group of pancreatic neoplasms: an investigation of tumour cell differentiation and K-ras, p53 and c-erbB-2 abnormalities in 26 patients.
Intratumor heterogeneity of k-ras and p53 mutations among human colorectal adenomas containing early cancer.
Inverse relationship between APC gene mutation in gastric adenomas and development of adenocarcinoma.
Investigation of pathogenic mechanisms in multiple colorectal adenoma patients without germline APC or MYH/MUTYH mutations.
Involvement of APC and K-ras mutation in non-polypoid colorectal tumorigenesis.
K-ras activation generates an inflammatory response in lung tumors.
K-ras and p53 mutations in colonic lavage fluid of patients with colorectal neoplasias.
K-ras exon 4A has a tumour suppressor effect on carcinogen-induced murine colonic adenoma formation.
K-ras gene mutation in colorectal adenomas and carcinomas from familial adenomatous polyposis patients.
K-ras gene mutation related to histological atypias in human colorectal adenomas.
K-ras gene mutations and loss of heterozygosity at the p53 gene locus relative to histological characteristics of mucin-producing tumors of the pancreas.
K-ras gene mutations in adenomas and carcinomas of the colon.
K-ras gene mutations in normal colorectal tissues from K-ras mutation-positive colorectal cancer patients.
K-ras mutation and loss of heterozygosity of the adenomatous polyposis coli gene in patients with colorectal adenomas with in situ carcinoma.
K-ras mutation in a tubular adenoma originating at an ileostomy in a familial adenomatous polyposis patient.
K-ras mutation in adenomas and carcinomas of the ampulla of vater.
K-ras mutations and HLA-DR expression in large bowel adenomas.
K-ras mutations in aberrant crypt foci, adenomas and adenocarcinomas during azoxymethane-induced colon carcinogenesis.
K-ras mutations in incident sporadic colorectal adenomas.
K-ras mutations in mouse lung tumors of extreme age: independent of paternal preconceptional exposure to chromium(III) but significantly more frequent in carcinomas than adenomas.
K-ras mutations in sera of patients with colorectal neoplasias and long-standing inflammatory bowel disease.
K-ras oncogene mutations in rat colon tumors induced by N-methyl-N-nitrosourea.
K-ras point mutations in routinely processed tissues: non-radioactive screening by single strand conformational polymorphism analysis.
K-ras point mutations in the supernatants of pancreatic juice and bile are reliable for diagnosis of pancreas and biliary tract carcinomas complementary to cytologic examination.
K-Ras-Activated Cells Can Develop into Lung Tumors When Runx3-Mediated Tumor Suppressor Pathways Are Abrogated.
Laterally spreading type of colorectal adenoma exhibits a unique methylation phenotype and K-ras mutations.
Limited role of murine ATM in oncogene-induced senescence and p53-dependent tumor suppression.
Loss of RhoA Exacerbates, Rather Than Dampens, Oncogenic K-Ras Induced Lung Adenoma Formation in Mice.
Low frequency of H-ras activation in naturally occurring hepatocellular tumors of C3H/HeNCr mice.
Low frequency of TERT promoter mutations in a series of well-differentiated follicular-patterned thyroid neoplasms.
Lower incidence of K-ras codon 12 mutation in flat colorectal adenomas than in polypoid adenomas.
Meat consumption and preparation, and genetic susceptibility in relation to colorectal adenomas.
Melphalan inhibits adenoma development through modulating the expression of K-ras-specific markers in K-ras Tg mice.
Methylation of estrogen receptor 1 in colorectal adenomas is not age-dependent, but is correlated with K-ras mutation.
Microsatellite instability and K-ras mutations in gastric adenomas, with reference to associated gastric cancers.
Molecular analysis of sulindac-resistant adenomas in familial adenomatous polyposis.
Molecular characteristics of serrated adenomas of the colorectum.
Molecular events including p53 and k-ras alterations in the in vitro progression of a human colorectal adenoma cell line to an adenocarcinoma.
Molecular genetic analysis of appendiceal mucinous adenomas in identical twins, including one with pseudomyxoma peritonei.
Molecular genetic evidence supporting the clonality and appendiceal origin of Pseudomyxoma peritonei in women.
Molecular mechanism of stomach carcinogenesis.
Molecular mechanisms underlying the tumorigenesis of colorectal adenomas: correlation to activated K-ras oncogene.
Molecular screening for somatic mutations in corticotropic adenomas of dogs with pituitary-dependent hyperadrenocorticism.
Molecular screening of pituitary adenomas for gene mutations and rearrangements.
Mucinous cystic carcinoma of the pancreas: a unique cell line and xenograft model of a preinvasive lesion.
Multiple APC mutations in sporadic flat colorectal adenomas.
Murine lung tumor measurement using respiratory-gated micro-computed tomography.
Mutant K-ras promotes carcinogen-induced murine colorectal tumourigenesis, but does not alter tumour chromosome stability.
Mutated K-ras(Asp12) promotes tumourigenesis in Apc(Min) mice more in the large than the small intestines, with synergistic effects between K-ras and Wnt pathways.
Mutation of K-ras protooncogene is associated with histological subtypes in human mucinous ovarian tumors.
Mutations in the K-ras oncogene induced by 1,2-dimethylhydrazine in preneoplastic and neoplastic rat colonic mucosa.
Natural history of colorectal nonpolypoid adenomas: a prospective colonoscopic study and relation with cell kinetics and K-ras mutations.
No major difference in K-ras and p53 abnormalities in sporadic and hereditary nonpolyposis colorectal adenomas.
p53 and K-ras status in duodenal adenomas in familial adenomatous polyposis.
p53 expression and K-ras mutation in colorectal adenomas.
PCR-SSCP analysis of human adrenocortical adenomas: absence of K-ras gene mutations.
Peutz-Jeghers polyps, dysplasia, and K-ras codon 12 mutations.
Point mutations of ras and Gs alpha subunit genes in thyroid tumors.
Point mutations of ras oncogenes are an early event in thyroid tumorigenesis.
Polypoid growth and K-ras codon 12 mutation in colorectal cancer.
Possible carcinogenic effects of X-rays in a transgenerational study with CBA mice.
Prevalences of Gs alpha, ras, p53 mutations and ret/PTC rearrangement in differentiated thyroid tumours in a Korean population.
Profiling of transcripts and proteins modulated by K-ras oncogene in the lung tissues of K-ras transgenic mice by omics approaches.
Prognostic implications of routine, immunohistochemical, and molecular staging in resectable pancreatic adenocarcinoma.
Promoter hypermethylation of tumor-related genes in the progression of colorectal neoplasia.
Rab18 is reduced in pituitary tumors causing acromegaly and its overexpression reverts growth hormone hypersecretion.
Rap2A Is Upregulated in Invasive Cells Dissected from Follicular Thyroid Cancer.
Ras gene point mutations in gallbladder lesions associated with anomalous connection of pancreatobiliary ducts.
ras mutations in endocrine tumors: mutation detection by polymerase chain reaction-single strand conformation polymorphism.
Reduced MGMT activity in human colorectal adenomas is associated with K-ras GC->AT transition mutations in a population exposed to methylating agents.
Relationship between cyclooxygenase-2 expression and K-ras gene mutation in colorectal adenomas.
Relationships of DNA adduct formation, K-ras activating mutations and tumorigenic activities of 6-nitrochrysene and its metabolites in the lungs of CD-1 mice.
Role of oncogenic K-Ras in cancer stem cell activation by aberrant Wnt/?-catenin signaling.
Role of point mutation of the K-ras gene in tumorigenesis of B6C3F1 mouse lung lesions induced by urethane.
Role of the DPC4 tumor suppressor gene in adenocarcinoma of the ampulla of Vater: analysis of 140 cases.
Runx3 inactivation is a crucial early event in the development of lung adenocarcinoma.
Runx3 is required for the differentiation of lung epithelial cells and suppression of lung cancer.
Selective occurrence of ras mutations in benign and malignant thyroid follicular neoplasms in Taiwan.
Serrated adenomas have a pattern of genetic alterations that distinguishes them from other colorectal polyps.
Serrated route to colorectal cancer: back street or super highway?
Single-Pattern Convergence of K-ras Mutation Correlates With Surgical Indication of Intraductal Papillary Mucinous Neoplasms.
Somatic APC and K-ras codon 12 mutations in periampullary adenomas and carcinomas from familial adenomatous polyposis patients.
Synergism between K-rasVal12 and mutant Apc accelerates murine large intestinal tumourigenesis.
The genetics of colorectal cancer.
The pro-apoptotic K-Ras 4A proto-oncoprotein does not affect tumorigenesis in the ApcMin/+ mouse small intestine.
The rac activator Tiam1 is a Wnt-responsive gene that modifies intestinal tumor development.
The second intron of the K-ras gene contains regulatory elements associated with mouse lung tumor susceptibility.
The sequential accumulation of genetic alterations characteristic of the colorectal adenoma-carcinoma sequence does not occur between gastric adenoma and adenocarcinoma.
Thyroid hormone receptor beta1 in normal colon and colorectal cancer-association with differentiation, polypoid growth type and K-ras mutations.
Transfection and expression of mutant p53 protein does not alter the in vivo or in vitro growth characteristics of the AA/C1 human adenoma derived cell line, including sensitivity to transforming growth factor-beta 1.
Transforming growth factor beta1, ras and p53 in silica-induced fibrogenesis and carcinogenesis.
Utilization of K-ras mutations identified in stool DNA for the early detection of colorectal cancer.
Wild-type K-ras has a tumour suppressor effect on carcinogen-induced murine colorectal adenoma formation.
Wnt/beta-catenin/tcf signaling: a critical pathway in gastrointestinal tumorigenesis.
["Field cancerization"--an additional phenomenon in development of colon tumors? K-ras codon 12 mutations in normal colonic mucosa of patients with colorectal neoplasms]
[A study on the mutation of P53 and K-ras gene in colorectal adenomas and colorectal carcinomas].
[Detection of K-ras point mutations in the stool of patients with colorectal tumors]
[Effect of PCBs on mouse lung tumorigenesis induced by 1-nitropyrene: a preliminary report]
[Genes, heredity and colorectal cancer]
[Genetic alterations in gallbladder carcinoma: a review]
[Genetic analysis of adenomatous polyposis coli: analysis of alterations of oncogenes and tumor suppressor genes in colorectal tumors]
[Genome analyses for precancerous lesions in the gastrointestinal tract]
[Influence of compensatory hepatocyte proliferation on the carcinogenesis of N-nitrosodimethylamine]
[K-ras gene mutations in adenomas from familial adenomatous polyposis]
[Mutations of APC and K-ras gene in aberrant crypt foci from human colon]
[Oncogenes and anti-oncogenes in lung cancer]
[Pathophysiology and gene abnormalities of endocrine tumors]
[Precancerous lesion in colorectal cancer]
[The RAS paradoxon of the EGFR-targeted therapy of colorectal cancer]
[Thyroid carcinoma]
[Value of fecal and blood adenomatous polyposis coli gene and K-ras gene mutation detection in colorectal neoplasm screening]
Adenoma, Bile Duct
Infrequent activation of K-ras, H-ras, and other oncogenes in hepatocellular neoplasms initiated by methyl(acetoxymethyl)nitrosamine, a methylating agent, and promoted by phenobarbital in F344 rats.
Adenoma, Islet Cell
Analysis of ras gene mutations in biliary and pancreatic tumors by polymerase chain reaction and direct sequencing.
Detection of point mutations in the K-ras oncogene at codon 12 in pure pancreatic juice for diagnosis of pancreatic carcinoma.
Polymerase chain reaction-based K-ras mutation detection of pancreatic adenocarcinoma in routine cytology smears.
[Detection of ras gene mutations of pancreatic tumors by polymerase chain reaction and direct sequencing method]
[Point mutation of K-ras gene in pancreatic carcinoma]
Adenoma, Liver Cell
Correlation between Bcl-2 overexpression and H-ras mutation in naturally occurring hepatocellular proliferative lesions of the B6C3F1 mouse.
H-ras 61st codon activation in archival proliferative hepatic lesions isolated from female B6C3F1 mice exposed to the leukotriene D4-antagonist, LY171883.
Infrequent activation of K-ras, H-ras, and other oncogenes in hepatocellular neoplasms initiated by methyl(acetoxymethyl)nitrosamine, a methylating agent, and promoted by phenobarbital in F344 rats.
Low frequency of H-ras activation in naturally occurring hepatocellular tumors of C3H/HeNCr mice.
Low frequency of H-ras mutations in hepatocellular adenomas and carcinomas and in hepatoblastomas from B6C3F1 mice exposed to oxazepam in the diet.
Adenoma, Pleomorphic
Expression of ras-P21 and ras gene alteration in pleomorphic adenomas.
H-ras gene mutations in salivary gland pleomorphic adenomas.
Adenoma, Villous
A study of ras gene mutations in colonic adenomas from familial polyposis coli patients.
A very large villous adenoma with an adjacent cancer of the rectum: an informative case for testing the proposed molecular basis of colorectal tumorigenesis.
Adenomatous Polyposis Coli
A study of ras gene mutations in colonic adenomas from familial polyposis coli patients.
Abberant crypt foci -- importance in colorectal carcinogenesis and expression of p53 and mdm2: a changing concept.
Aberrant crypt foci: detection, gene abnormalities, and clinical usefulness.
Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth.
Age-associated loss of heterozygosity of tumor suppressor genes in the gastric mucosa of humans.
Analysis of K-ras, APC, and beta-catenin in aberrant crypt foci in sporadic adenoma, cancer, and familial adenomatous polyposis.
APC loss-induced intestinal tumorigenesis in Drosophila: Roles of Ras in Wnt signaling activation and tumor progression.
APC, K-ras, and p53 gene mutations in colorectal cancer patients: correlation to clinicopathologic features and postoperative surveillance.
Application of cycling gradient capillary electrophoresis to detection of APC, K-ras, and DCC point mutations in patients with sporadic colorectal tumors.
Biological consequences of the genetic changes which occur during human colorectal carcinogenesis.
BRAF mutations in multiple sebaceous hyperplasias of patients belonging to MYH-associated polyposis pedigrees.
Cancer risk assessment in long-standing pouchitis. DNA aberrations are rare in transformed neoplastic pelvic pouch mucosa.
Cdc42 regulates GSK-3beta and adenomatous polyposis coli to control cell polarity.
Chronic ulcerative colitis and colorectal cancer.
Clonality assessment and clonal ordering of individual neoplastic crypts shows polyclonality of colorectal adenomas.
Clonality, founder mutations, and field cancerization in human ulcerative colitis-associated neoplasia.
Colon cancer: a civilization disorder.
Colon Cancer: A Clinician's Perspective in 2019.
Colon carcinoma K-ras 2 oncogene of a familial polyposis coli patient.
Colorectal adenoma to carcinoma progression follows multiple pathways of chromosomal instability.
Comparative molecular pathology of sporadic hyperplastic polyps and neoplastic lesions from the same individual.
Differential colorectal carcinogenesis: Molecular basis and clinical relevance.
DNA alterations of microsatellite DNA, p53, APC and K-ras in Chinese colorectal cancer patients.
Fecal multiple molecular tests to detect colorectal cancer in stool.
Gene alterations in intestinal metaplasia and gastric cancer.
Genetic alterations in ulcerative colitis-associated neoplasia focusing on APC, K-ras gene and microsatellite instability.
Genetic changes and histopathological types in colorectal tumors from patients with familial adenomatous polyposis.
Genomic instability and colon carcinogenesis: from the perspective of genes.
Germline and somatic mutations in exon 15 of the APC gene and K-ras mutations in duodenal adenomas in patients with familial adenomatous polyposis.
High-degree tumor budding and podia-formation in sporadic colorectal carcinomas with K-ras gene mutations.
Influence of age on adenomatous polyposis coli and p53 mutation frequency in sporadic colorectal cancer-rarity of co-occurrence of mutations in APC, K-ras, and p53 genes.
IQGAP1 Expression in Spared CA1 Neurons After an Excitotoxic Lesion in the Mouse Hippocampus.
IQGAP1 stimulates actin assembly through the N-WASP-Arp2/3 pathway.
IQGAP1: a key regulator of adhesion and migration.
K-ras activation in colorectal tumors from patients with familial polyposis coli.
K-ras gene mutation in colorectal adenomas and carcinomas from familial adenomatous polyposis patients.
K-ras mutation and loss of heterozygosity at 17p with beta-catenin accumulation in intramucosal carcinoma of the ileostomy in familial adenomatous polyposis: a case report.
K-ras mutation and loss of heterozygosity of the adenomatous polyposis coli gene in patients with colorectal adenomas with in situ carcinoma.
K-ras mutation in a tubular adenoma originating at an ileostomy in a familial adenomatous polyposis patient.
Lessons learned from colorectal model of tumourigenesis.
Microsatellite instability in colorectal cancer.
Molecular and biological analysis of carcinoma of the small intestine: beta-catenin gene mutation by interstitial deletion involving exon 3 and replication error phenotype.
MutY and MutY homologs (MYH) in genome maintenance.
MutYH (MYH) and colorectal cancer.
Novel targeting approaches and signaling pathways of colorectal cancer: An insight.
Orthotopic xenografts of human pancreatic carcinomas acquire genetic aberrations during dissemination in nude mice.
p53 and K-ras status in duodenal adenomas in familial adenomatous polyposis.
Phenotype-genotype correlation: Challenge of intestinal-type adenocarcinoma of the nasal cavity and paranasal sinuses.
Prolonged chronic inflammation progresses to dysplasia in a novel rat model of colitis-associated colon cancer.
Regulation of cyclooxygenase-2 expression by the Wnt and ras pathways.
Rho GTPase Cdc42 is a direct interacting partner of Adenomatous Polyposis Coli protein and can alter its cellular localization.
Role of oncogenic K-Ras in cancer stem cell activation by aberrant Wnt/?-catenin signaling.
Sensitivity and specificity of a stool DNA multitarget assay panel for the detection of advanced colorectal neoplasia.
Somatic APC and K-ras codon 12 mutations in periampullary adenomas and carcinomas from familial adenomatous polyposis patients.
Somatic mutations of the adenomatous polyposis coli gene in gastroduodenal tumors from patients with familial adenomatous polyposis.
The differentially mutational spectra of the APC, K-ras, and p53 genes in sporadic colorectal cancers from Taiwanese patients.
The origins of rimmed vacuoles and granulovacuolar degeneration bodies are associated with the Wnt signaling pathway.
Wnt/beta-catenin/tcf signaling: a critical pathway in gastrointestinal tumorigenesis.
[Cytomolecular aspects of colorectal carcinoma]
[Genes, heredity and colorectal cancer]
[Genome analyses for precancerous lesions in the gastrointestinal tract]
[K-ras gene mutations in adenomas from familial adenomatous polyposis]
[Polymerase chain reaction--principles and clinical relevance]
[Value of fecal and blood adenomatous polyposis coli gene and K-ras gene mutation detection in colorectal neoplasm screening]
Adenomatous Polyps
Detection of a K-ras mutation in urine of patients with colorectal cancer.
Detection of mutated K-ras DNA in urine, plasma, and serum of patients with colorectal carcinoma or adenomatous polyps.
Human urine contains small, 150 to 250 nucleotide-sized, soluble DNA derived from the circulation and may be useful in the detection of colorectal cancer.
Adenomyosis
Expression of motility-related molecule Cdc42 in endometrial tissue in women with adenomyosis and ovarian endometriomata.
Adrenocortical Adenoma
PCR-SSCP analysis of human adrenocortical adenomas: absence of K-ras gene mutations.
Adrenocortical Carcinoma
Absent ras gene mutations in human adrenal cortical neoplasms and pheochromocytomas.
Albinism
A novel Rab27a mutation binds melanophilin, but not Munc13-4, causing immunodeficiency without albinism.
Griscelli Syndrome Type 2 Sine Albinism: Unraveling Differential RAB27A Effector Engagement.
Patients with Griscelli syndrome and normal pigmentation identify RAB27A mutations that selectively disrupt MUNC13-4 binding.
Albinism, Oculocutaneous
A mutation in Rab38 small GTPase causes abnormal lung surfactant homeostasis and aberrant alveolar structure in mice.
Analysis and expression of Rab38 in oculocutaneous lung disease.
Expression and characterization of Rab38, a new member of the Rab small G protein family.
Lethal hemophagocytic lymphohistiocytosis in Hermansky-Pudlak syndrome type II.
Patients with Griscelli syndrome and normal pigmentation identify RAB27A mutations that selectively disrupt MUNC13-4 binding.
[Hypomelanoses transmitted from generation to generation].
Albuminuria
Rab38 modulates proteinuria in model of hypertension-associated renal disease.
The Rab-Rabphilin system in injured human podocytes stressed by glucose overload and angiotensin II.
Alzheimer Disease
A meta-analysis of transcriptomic profiles of Huntington's disease patients.
Altered Distribution of RhoA in Alzheimer's Disease and AbetaPP Overexpressing Mice.
Altered distribution of RhoA in Alzheimer's disease and AbetaPP overexpressing mice.
Altered Expression of Circulating Cdc42 in Frontotemporal Lobar Degeneration.
Association between thiopurine medication exposure and Alzheimer's disease among a cohort of patients with inflammatory bowel disease.
Behavioral effects of Rho GTPase modulation in a model of Alzheimer's disease.
Crosstalk between Rap1 and Rac regulates secretion of sAPPalpha.
Induction of p21ras in Alzheimer pathology.
Lemur tail kinase 1 (LMTK1) regulates the endosomal localization of ?-secretase BACE1.
Oligomer ?-amyloid Induces Hyperactivation of Ras to Impede NMDA Receptor-Dependent Long-Term Potentiation in Hippocampal CA1 of Mice.
Opposing functions for retromer and Rab11 in extracellular vesicle traffic at presynaptic terminals.
Quantitation of glycogen synthase kinase-3 sensitive proteins in neuronal membrane rafts.
Re-exploring the core genes and modules in the human frontal cortex during chronological aging: insights from network-based analysis of transcriptomic studies.
Reduced expression of amyloid precursor protein, presenilin-1 and rab3a in cortical brain regions in Alzheimer's disease.
Reducing Endogenous ?-Synuclein Mitigates the Degeneration of Selective Neuronal Populations in an Alzheimer's Disease Transgenic Mouse Model.
Synaptic proteins predict cognitive decline in Alzheimer's disease and Lewy body dementia.
[RhoA/ROCK pathway involved in effects of Sanjiao acupuncture on learning and memory and synaptic plasticity in Alzheimer's disease mice].
Ameloblastoma
Immunohistochemical expression of Rho GTPases in ameloblastomas.
K-Ras gene status and expression of Ras/mitogen-activated protein kinase (MAPK) signaling molecules in ameloblastomas.
Amyotrophic Lateral Sclerosis
ALS2CL, the novel protein highly homologous to the carboxy-terminal half of ALS2, binds to Rab5 and modulates endosome dynamics.
Loss of endosomal recycling factor RAB11 coupled with complex regulation of MAPK/ERK/AKT signaling in postmortem spinal cord specimens of sporadic amyotrophic lateral sclerosis patients.
The N-terminal intrinsically disordered region mediates intracellular localization and self-oligomerization of ALS2.
Anaphylaxis
Rab27b regulates mast cell granule dynamics and secretion.
Anemia
Cdc42 critically regulates the balance between myelopoiesis and erythropoiesis.
The scat mouse model highlights RASA3, a GTPase activating protein, as a key regulator of vertebrate erythropoiesis and megakaryopoiesis.
Angiomyolipoma
Frequent [corrected] hyperphosphorylation of ribosomal protein S6 [corrected] in lymphangioleiomyomatosis-associated angiomyolipomas.
Anus, Imperforate
Loss of function IFT27 variants associated with an unclassified lethal fetal ciliopathy with renal agenesis.
Aortic Coarctation
Effect of experimental hypertension on phosphoinositide hydrolysis and proto-oncogene expression in cardiovascular tissues.
Appendiceal Neoplasms
K-ras and p53 mutations in the pathogenesis of classical and goblet cell carcinoids of the appendix.
Arteriosclerosis
Adenovirus-mediated transfer of dominant-negative rho-kinase induces a regression of coronary arteriosclerosis in pigs in vivo.
In vivo gene transfer of dominant-negative rho-kinase induces regression of coronary arteriosclerosis in pigs.
Long-term inhibition of Rho-kinase ameliorates hypoxia-induced pulmonary hypertension in mice.
Long-term inhibition of Rho-kinase suppresses neointimal formation after stent implantation in porcine coronary arteries: involvement of multiple mechanisms.
Long-term treatment with a Rho-kinase inhibitor improves monocrotaline-induced fatal pulmonary hypertension in rats.
Long-term treatment with a specific Rho-kinase inhibitor suppresses cardiac allograft vasculopathy in mice.
RASL11B gene enhances hyaluronic acid-mediated chondrogenic differentiation in human amniotic mesenchymal stem cells via the activation of Sox9/ERK/smad signals.
Arthritis
Genetic loci contributing to hemophagocytic lymphohistiocytosis do not confer susceptibility to systemic-onset juvenile idiopathic arthritis.
Protein prenylation restrains innate immunity by inhibiting Rac1 effector interactions.
RhoB blockade selectively inhibits autoantibody production in autoimmune models of rheumatoid arthritis and lupus.
T cell activation Rho GTPase activating protein (TAGAP) is upregulated in clinical and experimental arthritis.
Arthritis, Experimental
Silencing the Expression of Ras Family GTPase Homologues Decreases Inflammation and Joint Destruction in Experimental Arthritis.
Arthritis, Juvenile
Genetic loci contributing to hemophagocytic lymphohistiocytosis do not confer susceptibility to systemic-onset juvenile idiopathic arthritis.
Arthritis, Psoriatic
Rho-GTPase pathways may differentiate treatment response to TNF-alpha and IL-17A inhibitors in psoriatic arthritis.
Arthritis, Rheumatoid
HMG-CoA reductase inhibitor simvastatin suppresses Toll-like receptor 2 ligand-induced activation of nuclear factor kappa B by preventing RhoA activation in monocytes from rheumatoid arthritis patients.
K-RAS GTPase- and B-RAF kinase-mediated T-cell tolerance defects in rheumatoid arthritis.
Signal transduction pathways in chronic inflammatory autoimmune disease: small GTPases.
Smoothened Regulates Migration of Fibroblast-Like Synoviocytes in Rheumatoid Arthritis via Activation of Rho GTPase Signaling.
Sustained T cell Rap1 signaling is protective in the collagen-induced arthritis model of rheumatoid arthritis.
Tetrandrine inhibits migration and invasion of rheumatoid arthritis fibroblast-like synoviocytes through down-regulating the expressions of Rac1, Cdc42, and RhoA GTPases and activation of the PI3K/Akt and JNK signaling pathways.
[Modulation of RhoA/Rho kinase on migration, invasion and proliferation of fibroblast like synoviocytes from patients with rheumatoid arthritis].
[Modulation of RhoA/ROCK pathway on TLR-2 ligand-induced chemokine secretion in fibroblast-like synoviocytes from patients with rheumatoid arthritis].
Asbestosis
Comparative analysis of p16/CDKN2, p53 and ras gene alterations in human non-small cell lung cancers, with and without associated pulmonary asbestosis.
k-ras mutation and occupational asbestos exposure in lung adenocarcinoma: asbestos-related cancer without asbestosis.
Asthenozoospermia
Involvement of sperm plasma membrane and cytoskeletal proteins in human male infertility.
Asthma
A Role for the Rho-GTPase Pathway in Pediatric Obese Asthma.
Arf6 exacerbates allergic asthma through cell-to-cell transmission of ASC inflammasomes.
CDC42-related genes are upregulated in helper T cells from obese asthmatic children.
Farnesyltransferase Inhibition Exacerbates Eosinophilic Inflammation and Airway Hyperreactivity in Mice with Experimental Asthma: The Complex Roles of Ras GTPase and Farnesylpyrophosphate in Type 2 Allergic Inflammation.
Functional Genomics of the Pediatric Obese Asthma Phenotype Reveal Enrichment of Rho-GTPase Pathways.
Inhibition of p21-activated kinase 1 attenuates the cardinal features of asthma through suppressing the lymph node homing of dendritic cells.
MicroRNAs and Their Therapeutic Potential for Human Diseases: MiR-133a and Bronchial Smooth Muscle Hyperresponsiveness in Asthma.
Rational targeting Cdc42 restrains Th2 cell differentiation and prevents allergic airway inflammation.
RhoA and Cdc42 in T cells: Are they targetable for T cell-mediated inflammatory diseases?
Targeting the mevalonate cascade as a new therapeutic approach in heart disease, cancer and pulmonary disease.
Type II alveolar epithelial cell-specific loss of RhoA exacerbates allergic airway inflammation through SLC26A4.
[Non-coding RNAs and bronchial smooth muscle hyperresponsiveness in allergic bronchial asthma].
Astrocytoma
Aberrant G protein signaling in nervous system tumors.
Chromosomal changes and correspondingly altered proto-oncogene expression in human gliomas. Value of combined cytogenetic and molecular genetic analysis.
Combined erbB gene overexpression and decreased H-ras gene expression in human gliomas.
ECT2 and RASAL2 mediate mesenchymal-amoeboid transition in human astrocytoma cells.
Ghrelin and the growth hormone secretagogue receptor constitute a novel autocrine pathway in astrocytoma motility.
H-Ras increases urokinase expression and cell invasion in genetically modified human astrocytes through Ras/Raf/MEK signaling pathway.
Implication of the small GTPase Rac1 in the generation of reactive oxygen species in response to beta-amyloid in C6 astroglioma cells.
Increased neurofibromatosis 1 gene expression in astrocytic tumors: positive regulation by p21-ras.
Insulin-like growth factor binding protein 2 promotes glioma development and progression.
Rab23 is overexpressed in human astrocytoma and promotes cell migration and invasion through regulation of Rac1.
Ras oncogene mutations in childhood brain tumors.
Targeting Ras-RAF-ERK and its Interactive Pathways as a Novel Therapy for Malignant Gliomas.
The regulation of RhoA at focal adhesions by StarD13 is important for astrocytoma cell motility.
Ataxia
Blocking of p53-Snail binding, promoted by oncogenic K-Ras, recovers p53 expression and function.
Ral GTPase down-regulation stabilizes and reactivates p53 to inhibit malignant transformation.
Atherosclerosis
A crucial role for CDC42 in senescence-associated inflammation and atherosclerosis.
Chlamydia pneumoniae infection promotes a proliferative phenotype in the vasculature through Egr-1 activation in vitro and in vivo.
Endothelial Rap1 (Ras-Association Proximate 1) Restricts Inflammatory Signaling to Protect From the Progression of Atherosclerosis.
High glucose-induced upregulation of Rho / Rho-kinase via platelet-derived growth factor receptor-beta increases migration of aortic smooth muscle cells.
Inhibition of Rac1 GTPase Decreases Vascular Oxidative Stress, Improves Endothelial Function, and Attenuates Atherosclerosis Development in Mice.
Lack of mutations in K-ras codons 12 and 13 in human atherosclerotic lesions.
Lack of RAC1 in macrophages protects against atherosclerosis.
Map4k4 Signaling Nodes in Metabolic and Cardiovascular Diseases.
Rho-GTPase and Atherosclerosis: Pleiotropic Effects of Statins.
Role of small GTPase protein Rac1 in cardiovascular diseases: development of new selective pharmacological inhibitors.
Small GTPase and Regulation of Inflammation Response in Atherogenesis.
[Transcriptional expression of oncogenes and Rb antioncogene in experimental atherosclerotic lesions]
Atrial Fibrillation
Cardiac Rac1 overexpression in mice creates a substrate for atrial arrhythmias characterized by structural remodelling.
Identification of Co-expressed Genes Between Atrial Fibrillation and Stroke.
Membrane translocation of small GTPase Rac1 and activation of STAT1 and STAT3 in pacing-induced sustained atrial fibrillation.
Rac1-Mediated Effects of HMG-CoA Reductase Inhibitors (Statins) in Cardiovascular Disease.
Role of Rac1 GTPase activation in atrial fibrillation.
Simvastatin attenuates the oxidative stress, endothelial thrombogenicity and the inducibility of atrial fibrillation in a rat model of ischemic heart failure.
Autoimmune Diseases
Reciprocal Regulation of Glycolysis-Driven Th17 Pathogenicity and Regulatory T Cell Stability by Cdc42.
SAP and XIAP deficiency in hemophagocytic lymphohistiocytosis.
Autoimmune Pancreatitis
Endoscopic ultrasound fine needle aspirate DNA analysis to differentiate malignant and benign pancreatic masses.
Frequent and Significant K-ras Mutation in the Pancreas, the Bile Duct, and the Gallbladder in Autoimmune Pancreatitis.
K-ras mutation in the major duodenal papilla and gastric and colonic mucosa in patients with autoimmune pancreatitis.
[IgG4-related sclerosing disease, including its relation to carcinogenesis].
Azoospermia
Expression and significance of Rap1A in testes of azoospermic subjects.
Bacteremia
Escherichia coli ?-hemolysin counteracts the anti-virulence innate immune response triggered by the Rho GTPase activating toxin CNF1 during bacteremia.
Immunoproteomic to analysis the pathogenicity factors in leukopenia caused by Klebsiella pneumonia bacteremia.
Bacterial Infections
A Small GTPase, RhoA, Inhibits Bacterial Infection Through Integrin Mediated Phagocytosis in Invertebrates.
Arabidopsis EF-Tu receptor enhances bacterial disease resistance in transgenic wheat.
Enhancement of innate immune system in monocot rice by transferring the dicotyledonous elongation factor Tu receptor EFR.
Genomic annotation and expression analysis of the zebrafish Rho small GTPase family during development and bacterial infection.
Golgi-Resident GTPase Rab30 Promotes the Biogenesis of Pathogen-Containing Autophagosomes.
Identification, annotation and expression analysis of 29 Rho GTPase genes from channel catfish (Ictalurus punctatus) after bacterial infections.
Immunospecific responses to bacterial elongation factor Tu during Burkholderia infection and immunization.
Increased survival and reduced neutrophil infiltration of the liver in rab27a- but not munc13-4-deficient mice in lipopolysaccharide-induced systemic inflammation.
Innate immunity and exocytosis of antimicrobial peptides.
Role of the small GTPase Rap1 in signal transduction, cell dynamics and bacterial infection.
Bardet-Biedl Syndrome
A role for the vesicle-associated tubulin binding protein ARL6 (BBS3) in flagellum extension in Trypanosoma brucei.
Biochemical characterization of missense mutations in the Arf/Arl-family small GTPase Arl6 causing Bardet-Biedl syndrome.
Crystal structure of the small GTPase Arl6/BBS3 from Trypanosoma brucei.
High prevalence of Bardet-Biedl syndrome in La Réunion Island is due to a founder variant in ARL6/BBS3.
Identification of conserved, centrosome-targeting ASH domains in TRAPPII complex subunits and TRAPPC8.
IFT27, encoding a small GTPase component of IFT particles, is mutated in a consanguineous family with Bardet-Biedl syndrome.
Barrett Esophagus
Aneuploidy mechanisms in human colorectal preneoplastic lesions and Barrett's esophagus. Is there a role for K-ras and p53 mutations?
Increased immunoreactivity for Rab11, a small GTP-binding protein, in low-grade dysplastic Barrett's epithelia.
K-ras codon 12 mutations of the super-minute dysplasia in Barrett's esophagus by DNA extraction using a microdissection method.
Malignant progression in Barrett's esophagus: pathology and molecular biology.
[Molecular alterations in Barrett's esophagus and adenocarcinoma]
Bile Duct Neoplasms
Aberrations of the K-ras, p53, and APC genes in extrahepatic bile duct cancer.
Analysis of K-ras gene mutations in periampullary cancers, gallbladder cancers and cholangiocarcinomas from paraffin-embedded tissue sections.
Expression of oncogene products HER2/Neu and Ras and fibrosis-related growth factors bFGF, TGF-beta, and PDGF in bile from biliary malignancies and inflammatory disorders.
K-ras mutation, p53 overexpression, and microsatellite instability in biliary tract cancers: a population-based study in China.
p53 gene mutation and p53 protein overexpression in a patient with simultaneous double cancer of the gallbladder and bile duct associated with pancreaticobiliary maljunction.
Biliary Atresia
Congenital biliary atresia is correlated with disrupted cell junctions and polarity caused by Cdc42 insufficiency in the liver.
Biliary Tract Diseases
Analysis of K-ras gene mutations in human pancreatic cancer cell lines and in bile samples from patients with pancreatic and biliary cancers.
Biliary Tract Neoplasms
Cellular and molecular biology of biliary tract cancers.
Clinical and genetic analysis of noncancerous and cancerous biliary epithelium in patients with pancreaticobiliary maljunction.
Detection of point mutations in K-ras gene at codon 12 in bile from percutaneous transhepatic choledochal drainage tubes for diagnosis of biliary strictures.
K-ras codon 12 and p53 mutations in biopsy specimens and bile from biliary tract cancers.
K-Ras mutation and amplification status is predictive of resistance and high basal pAKT is predictive of sensitivity to everolimus in biliary tract cancer cell lines.
K-ras mutation, p53 overexpression, and microsatellite instability in biliary tract cancers: a population-based study in China.
Mutations of p16Ink4/CDKN2 and p15Ink4B/MTS2 genes in biliary tract cancers.
p53 overexpression and K-ras gene mutations in primary sclerosing cholangitis-associated biliary tract cancer.
Usefulness of K-ras gene mutation at codon 12 in bile for diagnosing biliary strictures.
Blast Crisis
Cell proliferation and drug resistance in hepatocellular carcinoma are modulated by Rho GTPase signals.
High frequency of RAS oncogene mutation in chronic myeloid leukemia patients with myeloblastoma.
Ras oncogene mutations are rare late stage events in chronic myelogenous leukemia.
Southern blot analysis of Bcr, N-ras, H-ras, c-myc and myb proto-oncogenes in blast crisis of chronic myelogenous leukemia.
Structural insights into the activation of the RhoA GTPase by the lymphoid blast crisis (Lbc) oncoprotein.
Blister
Bleb Expansion in Migrating Cells Depends on Supply of Membrane from Cell Surface Invaginations.
Cdc42 expression in keratinocytes is required for the maintenance of the basement membrane in skin.
Cell migration: fibroblasts find a new way to get ahead.
Developmental expression, co-localization and genetic interaction of exocyst component Sec15 with Rab11 during Drosophila development.
ESCRT-I Protein Tsg101 Plays a Role in the Post-macropinocytic Trafficking and Infection of Endothelial Cells by Kaposi's Sarcoma-Associated Herpesvirus.
Rab11 is required for cell adhesion, maintenance of cell shape and actin-cytoskeleton organization during Drosophila wing development.
SPECs, small binding proteins for Cdc42.
The ADP-ribosylation domain of Pseudomonas aeruginosa ExoS is required for membrane bleb niche formation and bacterial survival within epithelial cells.
THE ANGIOTENSIN II TYPE 1 RECEPTOR INDUCES MEMBRANE BLEBBING BY COUPLING TO RHO A, RHO KINASE AND MYOSIN LIGHT CHAIN KINASE.
The roles of Cdc42 and Rac1 in the formation of plasma membrane protrusions in cancer epithelial HeLa cells.
Bone Diseases, Metabolic
SLIT2 inhibits osteoclastogenesis and bone resorption by suppression of Cdc42 activity.
Bone Resorption
Aesculetin Inhibits Osteoclastic Bone Resorption through Blocking Ruffled Border Formation and Lysosomal Trafficking.
Cdc42 regulates bone modeling and remodeling in mice by modulating RANKL/M-CSF signaling and osteoclast polarization.
Downregulation of small GTPase Rab7 impairs osteoclast polarization and bone resorption.
Methods to Investigate the Role of Rho GTPases in Osteoclast Function.
Pharmacological inhibition of Dock5 prevents osteolysis by affecting osteoclast podosome organization while preserving bone formation.
Preservation of bone mass and structure in hibernating black bears (Ursus americanus) through elevated expression of anabolic genes.
Rac deletion in osteoclasts causes severe osteopetrosis.
Rho-GEF trio regulates osteoclast differentiation and function by Rac1/Cdc42.
SLIT2 inhibits osteoclastogenesis and bone resorption by suppression of Cdc42 activity.
Thienopyrimidine Bisphosphonate (ThPBP) Inhibitors of the Human Farnesyl Pyrophosphate Synthase: Optimization and Characterization of the Mode of Inhibition.
Bowen's Disease
Arsenic-related Bowen's disease and paraquat-related skin cancerous lesions show no detectable ras and p53 gene alterations.
Brain Diseases
BIG1 is required for the survival of deep layer neurons, neuronal polarity, and the formation of axonal tracts between the thalamus and neocortex in developing brain.
De novo variants in RHOBTB2, an atypical Rho GTPase gene, cause epileptic encephalopathy.
Early infantile epileptic encephalopathy associated with the disrupted gene encoding Slit-Robo Rho GTPase activating protein 2 (SRGAP2).
Missense Variants in RHOBTB2 Cause a Developmental and Epileptic Encephalopathy in Humans, and Altered Levels Cause Neurological Defects in Drosophila.
Reversing synapse loss in Alzheimer's disease: rho-guanosine triphosphatases and insights from other brain disorders.
The Role of Rac GTPase in Dendritic Spine Morphogenesis and Memory.
Brain Edema
Liver X receptor activation enhances blood-brain barrier integrity in the ischemic brain and increases the abundance of ATP-binding cassette transporters ABCB1 and ABCC1 on brain capillary cells.
Brain Injuries
CID1067700, a late endosome GTPase Rab7 receptor antagonist, attenuates brain atrophy, improves neurologic deficits and inhibits reactive astrogliosis in rat ischemic stroke.
Down-regulation Cdc42 attenuates neuronal apoptosis through inhibiting MLK3/JNK3 cascade during ischemic reperfusion in rat hippocampus.
Protection of Oligodendrocytes Through Neuronal Overexpression of the Small GTPase Ras in Hyperoxia-Induced Neonatal Brain Injury.
SVCT2 Promotes Neural Stem/Progenitor Cells Migration Through Activating CDC42 After Ischemic Stroke.
Brain Ischemia
Global brain ischemia and reperfusion: modifications in eukaryotic initiation factors associated with inhibition of translation initiation.
Role of Rac1 GTPase in JNK signaling and delayed neuronal cell death following global cerebral ischemia.
Role of Rac1 GTPase in NADPH oxidase activation and cognitive impairment following cerebral ischemia in the rat.
Brain Neoplasms
An Arf/Rab cascade controls the growth and invasiveness of glioblastoma.
BMI1 cooperates with H-RAS to induce an aggressive breast cancer phenotype with brain metastases.
Cerebral metastases as first symptom of cancer: a clinico-pathologic study.
Discordance of Mutation Statuses of Epidermal Growth Factor Receptor and K-ras between Primary Adenocarcinoma of Lung and Brain Metastasis.
Glial tumors in the MNU rat model: induction of pure and mixed gliomas that do not require typical missense mutations of p53.
Inhibition of H-ras as a treatment for experimental brain C6 glioma.
Lovastatin and perillyl alcohol inhibit glioma cell invasion, migration, and proliferation--impact of Ras-/Rho-prenylation.
PKM2 phosphorylates MLC2 and regulates cytokinesis of tumour cells.
Rab3a promotes brain tumor initiation and progression.
Rho GTPases in primary brain tumor malignancy and invasion.
The brain microenvironment negatively regulates miRNA-768-3p to promote K-ras expression and lung cancer metastasis.
Breast Diseases
Immunocytochemical demonstration and significance of p21 ras family oncogene product in benign and malignant breast disease.
Breast Neoplasms
14-3-3? promotes breast cancer invasion and metastasis by inhibiting RhoGDI?.
3D structure generation, virtual screening and docking of human Ras-associated binding (Rab3A) protein involved in tumourigenesis.
?-Adrenergic receptors suppress Rap1B prenylation and promote the metastatic phenotype in breast cancer cells.
?-Arrestin2 regulates lysophosphatidic acid-induced human breast tumor cell migration and invasion via Rap1 and IQGAP1.
A novel hydrogen sulfide-releasing donor, HA-ADT, suppresses the growth of human breast cancer cells through inhibiting the PI3K/AKT/mTOR and Ras/Raf/MEK/ERK signaling pathways.
A novel role for flotillin-1 in H-Ras-regulated breast cancer aggressiveness.
A transformation in the mechanism by which the urokinase receptor signals provides a selection advantage for estrogen receptor-expressing breast cancer cells in the absence of estrogen.
Abnormal expression of Rap2A as a prognostic marker for human breast cancer.
Actin Cytoskeleton Remodeling Drives Breast Cancer Cell Escape from Natural Killer-Mediated Cytotoxicity.
Activated ezrin promotes cell migration through recruitment of the GEF Dbl to lipid rafts and preferential downstream activation of Cdc42.
Activation of H-Ras and Rac1 correlates with epidermal growth factor-induced invasion in Hs578T and MDA-MB-231 breast carcinoma cells.
Additional characterization of a hexanucleotide polymorphic site in the first intron of human H-ras gene: comparative study of its alterations in non-small cell lung carcinomas and sporadic invasive breast carcinomas.
ADP Ribosylation Factor Like 2 (Arl2) Regulates Breast Tumor Aggressivity in Immunodeficient Mice.
ADP-ribosylation factor 1 controls the activation of the phosphatidylinositol 3-kinase pathway to regulate epidermal growth factor-dependent growth and migration of breast cancer cells.
Altered glucose metabolism in Harvey-ras transformed MCF10A cells.
Altered Rho GTPase signaling pathways in breast cancer cells.
AmotP130 regulates Rho GTPase and decreases breast cancer cell mobility.
Aplidin induces JNK-dependent apoptosis in human breast cancer cells via alteration of glutathione homeostasis, Rac1 GTPase activation, and MKP-1 phosphatase downregulation.
ASPP2 Is a Novel Pan-Ras Nanocluster Scaffold.
Assessing sequential oncogene amplification in human breast cancer.
Association between Glycodelin and Aryl Hydrocarbon Receptor in Iranian Breast Cancer Patients: Impact of Environmental Endocrine Disrupting Chemicals.
Bmi-1 promotes invasion and metastasis, and its elevated expression is correlated with an advanced stage of breast cancer.
BMI1 cooperates with H-RAS to induce an aggressive breast cancer phenotype with brain metastases.
BRCA1, C-erbB-2, and H-ras gene expressions in young women with breast cancer. An immunohistochemical study.
Breast tumor kinase (protein tyrosine kinase 6) regulates heregulin-induced activation of ERK5 and p38 MAP kinases in breast cancer cells.
Cadmium modulates H-ras expression and caspase-3 apoptotic cell death in breast cancer epithelial MCF-7 cells.
cAMP inhibits cell migration by interfering with Rac-induced lamellipodium formation.
Cannabidiolic acid, a major cannabinoid in fiber-type cannabis, is an inhibitor of MDA-MB-231 breast cancer cell migration.
CCL2/CCR2 chemokine signaling coordinates survival and motility of breast cancer cells through Smad3 and p42/44MAPK dependent mechanisms.
Cdc42 is a substrate for caspases and influences Fas-induced apoptosis.
Cdc42 negatively regulates intrinsic migration of highly aggressive breast cancer cells.
Cdc42 overexpression induces hyperbranching in the developing mammary gland by enhancing cell migration.
Cdc42: an effector and regulator of ErbB1 as a strategic target in breast cancer therapy.
Cellular protoonocogenes are infrequently amplified in untreated non-small cell lung cancer.
Characterization of a Dual Rac/Cdc42 Inhibitor MBQ-167 in Metastatic Cancer.
Characterization of AND-34 Function and Signaling.
Chromosome 13q12 encoded Rho GTPase activating protein suppresses growth of breast carcinoma cells, and yeast two-hybrid screen shows its interaction with several proteins.
Clinical relevance of H-RAS, K-RAS, and N-RAS mRNA expression in primary breast cancer patients.
Cloning and characterization of a novel small monomeric GTPase, RasL10B, with tumor suppressor potential
Cloning and characterization of a novel small monomeric GTPase, RasL10B, with tumor suppressor potential.
Cloning and sequencing of the 52K cathepsin D complementary deoxyribonucleic acid of MCF7 breast cancer cells and mapping on chromosome 11.
CNKSR1 serves as a scaffold to activate an EGFR phosphatase via exclusive interaction with RhoB-GTP.
Consumption of oxygen: a mitochondrial-generated progression signal of advanced cancer.
Cooperative induction of rat mammary cancer by radiation and 1-methyl-1-nitrosourea via the oncogenic pathways involving c-Myc activation and H-ras mutation.
Cytoplasmic p120ctn regulates the invasive phenotypes of E-cadherin-deficient breast cancer.
D4-GDI, a Rho GTPase regulator, promotes breast cancer cell invasiveness.
DeltaTAp73 upregulation correlates with poor prognosis in human tumors: putative in vivo network involving p73 isoforms, p53, and E2F-1.
Dexmedetomidine promotes breast cancer cell migration through Rab11-mediated secretion of exosomal TMPRSS2.
Differential effects of Ca(2+) on bisphosphonate-induced growth inhibition in breast cancer and mesothelioma cells.
Differential expression and mutation of the ras family genes in human breast cancer.
DLC2 operates as a tumor suppressor gene in breast cancer via the RhoGTPase pathway.
Downregulation of GRK5 hampers the migration of breast cancer cells.
Downregulation of Rab27A contributes to metformin-induced suppression of breast cancer stem cells.
Effect of microRNA-206 on cytoskeleton remodelling by downregulating Cdc42 in MDA-MB-231 cells.
Effect of Rab23 on the proliferation and apoptosis in breast cancer.
Effect of the secretory small GTPase Rab27B on breast cancer growth, invasion, and metastasis.
Emerging prognostic markers related to mesenchymal characteristics of poorly differentiated breast cancers.
Endometrial K-ras mutations in postmenopausal breast cancer patients treated with adjuvant tamoxifen or toremifene.
Enhanced Expression of Rab27A Gene by Breast Cancer Cells Promoting Invasiveness and the Metastasis Potential by Secretion of Insulin-Like Growth Factor-II.
Enhanced insulin signaling via Shc in human breast cancer.
Enhanced intrinsic migration of aggressive breast cancer cells by inhibition of Rac1 GTPase.
Epidemiology of susceptibility to breast cancer.
ErbB2-enhanced invasiveness of H-Ras MCF10A breast cells requires MMP-13 and uPA upregulation via p38 MAPK signaling.
Estrogen and resveratrol regulate Rac and Cdc42 signaling to the actin cytoskeleton of metastatic breast cancer cells.
Estrogen defines the dynamics and destination of transactivated EGF receptor in breast cancer cells: role of S1P? receptor and Cdc42.
Estrogen Regulates Vesicle Trafficking Gene Expression in EFF-3, EFM-19 and MCF-7 Breast Cancer Cells.
Evidence for Enhanced Exosome Production in Aromatase Inhibitor-Resistant Breast Cancer Cells.
Evidence of Rab3A expression, regulation of vesicle trafficking, and cellular secretion in response to heregulin in mammary epithelial cells.
Experimental, Clinical and Morphological Analysis of H-Ras Oncoproteins for Locally Advanced Breast Cancer.
Expression of p21 ras gene products in breast cancer relates to histological types and to receptor and nodal status.
Farnesyl transferase inhibitor FTI-277 inhibits breast cell invasion and migration by blocking H-Ras activation.
FGFR4 GLY388 isotype suppresses motility of MDA-MB-231 breast cancer cells by EDG-2 gene repression.
FilGAP, a GAP protein for Rac, regulates front-rear polarity and tumor cell migration through the ECM.
Focus on Cdc42 in Breast Cancer: New Insights, Target Therapy Development and Non-Coding RNAs.
Friend leukemia virus integration 1 activates the Rho GTPase pathway and is associated with metastasis in breast cancer.
Function of Slit/Robo signaling in breast cancer.
Functional analysis of the contribution of RhoA and RhoC GTPases to invasive breast carcinoma.
Galectin-3 regulates a molecular switch from N-Ras to K-Ras usage in human breast carcinoma cells.
Genetic analysis of H-ras intron-1 polymorphic and variable tandem repeat regions in human breast cancer.
Geranylgeranyltransferase I inhibitor GGTI-2154 induces breast carcinoma apoptosis and tumor regression in H-Ras transgenic mice.
Gliotoxin is a dual inhibitor of farnesyltransferase and geranylgeranyltransferase I with antitumor activity against breast cancer in vivo.
Glucan and resveratrol complex - possible synergistic effects on immune system.
Growth and motility inhibition of breast cancer cells by epidermal growth factor receptor degradation is correlated with inactivation of Cdc42.
H-ras dependent estrogenic effects of epidermal growth factor in the estrogen-independent breast cancer cell line MDA-MB-231.
H-ras gene amplification or mutation is not common in human primary breast cancer.
H-Ras induces Nrf2-Pin1 interaction: Implications for breast cancer progression.
H-ras, but not N-ras, induces an invasive phenotype in human breast epithelial cells: a role for MMP-2 in the H-ras-induced invasive phenotype.
Harnessing membrane trafficking to promote cancer spreading and invasion: The case of RAB2A.
HER-2/neu-Positive breast carcinoma: molecular concomitants by proteomic analysis and their therapeutic implications.
HER2/ErbB2-induced breast cancer cell migration and invasion require p120 catenin activation of Rac1 and Cdc42.
Heregulin beta1 promotes breast cancer cell proliferation through Rac/ERK-dependent induction of cyclin D1 and p21Cip1.
High Frequency of Codon 12 but not Codon 13 and 61 K-ras Gene Mutations in Invasive Ductal Carcinoma of Breast in a South Indian Population.
High glucose levels promote the proliferation of breast cancer cells through GTPases.
High susceptibility of human c-Ha-ras proto-oncogene transgenic rats to carcinogenesis: a cancer-prone animal model.
HOXC8 promotes breast tumorigenesis by transcriptionally facilitating cadherin-11 expression.
Hsa-miR-1 suppresses breast cancer development by down-regulating K-ras and long non-coding RNA MALAT1.
Hypoxia stimulates carcinoma invasion by stabilizing microtubules and promoting the Rab11 trafficking of the alpha6beta4 integrin.
Hypoxia-inducible factors and RAB22A mediate formation of microvesicles that stimulate breast cancer invasion and metastasis.
IBP regulates epithelial-to-mesenchymal transition and the motility of breast cancer cells via Rac1, RhoA and Cdc42 signaling pathways.
Identification of FDA-approved Drugs Targeting Breast Cancer Stem Cells Along With Biomarkers of Sensitivity.
Identification of h-ras-specific motif for the activation of invasive signaling program in human breast epithelial cells.
IL-4/IL-13 Stimulated Macrophages Enhance Breast Cancer Invasion Via Rho-GTPase Regulation of Synergistic VEGF/CCL-18 Signaling.
Immunohistochemical analysis reveals a protective effect of H-ras expression mediated via apoptosis in node-negative breast cancer patients.
Immunohistochemical detection of H-ras protooncoprotein p21 indicates favorable prognosis in node-negative breast cancer patients.
Immunohistochemical Staining for Ras-Related Protein 25 (RAB25) Associates with Luminal B Breast Cancer Subtype.
Impact of oncogenic K-RAS on YB-1 phosphorylation induced by ionizing radiation.
Inactivation of Rab27B-dependent signaling pathway by calycosin inhibits migration and invasion of ER-negative breast cancer cells.
Increased expression of Rab25 in breast cancer correlates with lymphatic metastasis.
Induction of Ras by SAF-1/MAZ through a feed-forward loop promotes angiogenesis in breast cancer.
Influence of ARHGAP29 on the Invasion of Mesenchymal-Transformed Breast Cancer Cells.
Inhibition of redox/Fyn/c-Cbl pathway function by Cdc42 controls tumour initiation capacity and tamoxifen sensitivity in basal-like breast cancer cells.
Inhibition of silibinin on migration and adhesion capacity of human highly metastatic breast cancer cell line, MDA-MB-231, by evaluation of ?1-integrin and downstream molecules, Cdc42, Raf-1 and D4GDI.
Inhibition of the Rho GTPase, Rac1, decreases estrogen receptor levels and is a novel therapeutic strategy in breast cancer.
Inhibitors of growth factor signalling.
Interaction between Peptidyl-prolyl Cis-trans Isomerase NIMA-interacting 1 and GTP-H-Ras: Implications for Aggressiveness of Human Mammary Epithelial Cells and Drug Resistance.
Invasion of breast cancer cells into collagen matrix requires TGF-? and Cdc42 signaling.
Involvement of ARHGEF10, GEF for RhoA, in Rab6/Rab8-mediating membrane traffic.
K-ras mutation in the endometrium of tamoxifen-treated breast cancer patients, with a comparison of tamoxifen and toremifene.
K-ras nanoclustering is subverted by overexpression of the scaffold protein galectin-3.
KLF5 promotes breast cancer proliferation, migration and invasion in part by upregulating the transcription of TNFAIP2.
Long non-coding RNA ARHGAP5-AS1 inhibits migration of breast cancer cell via stabilizing SMAD7 protein.
Long non-coding RNA RACGAP1P promotes breast cancer invasion and metastasis via miR-345-5p/RACGAP1-mediated mitochondrial fission.
Long noncoding RNA RHPN1-AS1 promotes colorectal cancer progression via targeting miR-7-5p/OGT axis.
Loss of a c-H-ras-1 allele and aggressive human primary breast carcinomas.
Loss of RAB1B promotes triple-negative breast cancer metastasis by activating TGF-?/SMAD signaling.
Loss of Rho GDI{alpha} and Resistance to Tamoxifen via Effects on Estrogen Receptor {alpha}.
M-Ras induces Ral and JNK activation to regulate MEK/ERK-independent gene expression in MCF-7 breast cancer cells.
Machine Learning Helps Identify New Drug Mechanisms in Triple-Negative Breast Cancer.
MALAT1 induced migration and invasion of human breast cancer cells by competitively binding miR-1 with cdc42.
Mammalian Actin-binding Protein-1/Hip-55 Interacts with FHL2 and Negatively Regulates Cell Invasion.
MDA-9/Syntenin (SDCBP) modulates small GTPases RhoA and Cdc42 via transforming growth factor ?1 to enhance epithelial-mesenchymal transition in breast cancer.
Mechanism of Akt1 inhibition of breast cancer cell invasion reveals a protumorigenic role for TSC2.
MICAL1 controls cell invasive phenotype via regulating oxidative stress in breast cancer cells.
MicroRNA-188-5p promotes apoptosis and inhibits cell proliferation of breast cancer cells via the MAPK signaling pathway by targeting Rap2c.
MicroRNA-192-5p inhibits migration of triple negative breast cancer cells and directly regulates Rho GTPase activating protein 19.
MicroRNA-382-5p aggravates breast cancer progression by regulating the RERG/Ras/ERK signaling axis.
MicroRNA-548j functions as a metastasis promoter in human breast cancer by targeting Tensin1.
miR-376c-3p modulates the properties of breast cancer stem cells by targeting RAB2A.
miR-433 inhibits breast cancer cell growth via the MAPK signaling pathway by targeting Rap1a.
MKL1 Mediates TGF-? Induced RhoJ Transcription to Promote Breast Cancer Cell Migration and Invasion.
Model-based unsupervised learning informs metformin-induced cell-migration inhibition through an AMPK-independent mechanism in breast cancer.
Modulation of ERK5 is a novel mechanism by which Cdc42 regulates migration of breast cancer cells.
Molecular basis for Rho GTPase signaling specificity.
Molecular genetic characterization of tamoxifen-associated endometrial cancer.
Monitoring of endometrial K-ras mutation in tamoxifen-treated patients with breast cancer.
Monitoring the Rab27 associated exosome pathway using nanoparticle tracking analysis.
Multiple Effects of a Novel Epothilone Analog on Cellular Processes and Signaling Pathways Regulated by Rac1 GTPase in the Human Breast Cancer Cells.
Mutation profile of the p53, fhit, p16INK4a/p19ARF and H-ras genes in Indian breast carcinomas.
Mutation status of genes encoding RhoA, Rac1, and Cdc42 GTPases in a panel of invasive human colorectal and breast tumors.
Mutational activation of k-ras oncogene in human breast-tumors.
Myosin-interacting guanine exchange factor (MyoGEF) regulates the invasion activity of MDA-MB-231 breast cancer cells through activation of RhoA and RhoC.
N-WASP activation by a beta1-integrin-dependent mechanism supports PI3K-independent chemotaxis stimulated by urokinase-type plasminogen activator.
Negative regulation of CDC42 expression and cell cycle progression by miR-29a in breast cancer.
Neoadjuvant Therapy with Drug Arglabin for Breast Cancer with Expression of H-Ras Oncoproteins.
New Variations in the Promoter Regions of Human DOCK4 and RAP1A Genes, and Coding Regions of RAP1A in Sporadic Breast Tumors.
Newly formed E-cadherin contacts do not activate Cdc42 or induce filopodia protrusion in human keratinocytes1.
Nischarin is differentially expressed in rat brain and regulates neuronal migration.
Novel ternary vanadium-betaine-peroxido species suppresses H-ras and matrix metalloproteinase-2 expression by increasing reactive oxygen species-mediated apoptosis in cancer cells.
Numerical analysis of intracellular amino acid profiles of breast cancer cells with K-Ras or PI3K mutation in response to kinase inhibitors.
Oncodevelopmental expression of--GlcNAc beta 1-6Man alpha 1-6Man beta 1--branched asparagine-linked oligosaccharides in murine tissues and human breast carcinomas.
Oncogene activation in malignant transformation: a study of H-ras in human breast cancer.
Optical anisotropy of toluidine blue-stained transformed cell nuclei.
Overexpression of the secretory small GTPase Rab27B in human breast cancer correlates closely with lymph node metastasis and predicts poor prognosis.
p38{gamma} promotes breast cancer cell motility and metastasis through regulation of RhoC GTPase, cytoskeletal architecture, and a novel leading edge behavior.
Paxillin, a novel controller in the signaling of estrogen to FAK/N-WASP/Arp2/3 complex in breast cancer cells.
PDZ and LIM domain protein 1(PDLIM1)/CLP36 promotes breast cancer cell migration, invasion and metastasis through interaction with ?-actinin.
Phenotypic characterisation of breast cancer: the role of CDC42.
Phloretin induces apoptosis in H-Ras MCF10A human breast tumor cells through the activation of p53 via JNK and p38 mitogen-activated protein kinase signaling.
Pleiotropic functions of Rho GTPase signaling: a Trojan horse or Achilles' heel for breast cancer treatment?
Predictive and prognostic biomarkers with therapeutic targets in breast, colorectal, and non-small cell lung cancers: A systemic review of current development, evidence, and recommendation.
Quantitative proteomics and transcriptomics addressing the estrogen receptor subtype-mediated effects in T47D breast cancer cells exposed to the phytoestrogen genistein.
Rab18 is not necessary for lipid droplet biogenesis or turnover in human mammary carcinoma cells.
Rab2 promotes autophagic and endocytic lysosomal degradation.
RAB27A, RAB27B and VPS36 are downregulated in advanced prostate cancer and show functional relevance in prostate cancer cells.
RAB2A controls MT1-MMP endocytic and E-cadherin polarized Golgi trafficking to promote invasive breast cancer programs.
Rab35 is required for Wnt5a/Dvl2-induced Rac1 activation and cell migration in MCF-7 breast cancer cells.
Rac1 and Rac3 isoform activation is involved in the invasive and metastatic phenotype of human breast cancer cells.
Rac1 contributes to trastuzumab resistance of breast cancer cells: Rac1 as a potential therapeutic target for the treatment of trastuzumab-resistant breast cancer.
RAC1 GTPase promotes the survival of breast cancer cells in response to hyper-fractionated radiation treatment.
Ras p21 in breast tissue: associations with pathology and cellular localisation.
Ras stimulation of E2F activity and a consequent E2F regulation of integrin alpha6beta4 promote the invasion of breast carcinoma cells.
Ras-induced resistance to lapatinib is overcome by MEK inhibition.
Recombinant anthrax lethal toxin inhibits cell motility and invasion in breast cancer cells through the dysregulation of Rho GTPases.
Recurrent breast cancer and an adenocarcinoma of the lung occurring in one patient: c-myc oncogene amplification and K-ras codon 12 point mutation as tumour markers.
Regions of H- and K-ras that provide organ specificity/potency in mammary cancer induction.
Regulation of fatty acid synthase expression in breast cancer by sterol regulatory element binding protein-1c.
Relationship between metastatic ability and H-ras oncogene expression in rat mammary cancer cells transfected with the v-H-ras oncogene.
Requirement for Arf6 in breast cancer invasive activities.
RGS-GAIP-interacting protein controls breast cancer progression.
Rho family GTPases regulate mammary epithelium cell growth and metastasis through distinguishable pathways.
Rho GTPase Activating Protein 24 (ARHGAP24) Regulates the Anti-Cancer Activity of Sorafenib Against Breast Cancer MDA-MB-231 Cells via the Signal Transducer and Activator of Transcription 3 (STAT3) Signaling Pathway.
Rho GTPases are over-expressed in human tumors.
Rho-GTPase activating-protein 18: a biomarker associated with good prognosis in invasive breast cancer.
RhoB differentially controls Akt function in tumor cells and stromal endothelial cells during breast tumorigenesis.
RhoB is regulated by hypoxia and modulates metastasis in breast cancer.
RhoC Modulates Cell Junctions and Type I Interferon Response in Aggressive Breast Cancers.
RNAi screens for Rho GTPase regulators of cell shape and YAP/TAZ localisation in triple negative breast cancer.
Role of EHD2 in migration and invasion of human breast cancer cells.
Role of Rac1/WAVE2 Signaling in Mediating the Inhibitory Effects of ?-Tocotrienol on Mammary Cancer Cell Migration and Invasion.
Role of Rho GTPases in breast cancer.
Sensitization to the lysosomal cell death pathway by oncogene-induced down-regulation of lysosome-associated membrane proteins 1 and 2.
Shotgun proteomics coupled to nanoparticle-based biomarker enrichment reveals a novel panel of extracellular matrix proteins as candidate serum protein biomarkers for early-stage breast cancer detection.
Signal transduction elements of TC21, an oncogenic member of the R-Ras subfamily of GTP-binding proteins.
Small G protein signalling modulator 2 (SGSM2) is involved in oestrogen receptor-positive breast cancer metastasis through enhancement of migratory cell adhesion via interaction with E-cadherin.
Small GTPase Rho regulates R-cadherin through Dia1/profilin-1.
SP1 and STAT3 Functionally Synergize to Induce the RhoU Small GTPase and a Subclass of Non-canonical WNT Responsive Genes Correlating with Poor Prognosis in Breast Cancer.
Spatially distinct binding of Cdc42 to PAK1 and N-WASP in breast carcinoma cells.
Specific H-Ras minisatellite alleles in breast cancer susceptibility.
STAT3 Stabilizes IKK? Protein through Direct Interaction in Transformed and Cancerous Human Breast Epithelial Cells.
Stretch Induces Invasive Phenotypes in Breast Cells Due to Activation of Aerobic-Glycolysis-Related Pathways.
Targeting Cdc42 with the anticancer compound MBQ-167 inhibits cell polarity and growth in the budding yeast S. cerevisiae.
Targeting the phosphatidylinositol 3-kinase/Akt pathway for enhancing breast cancer cells to radiotherapy.
Targeting TRAF3IP2, Compared to Rab27, is More Effective in Suppressing the Development and Metastasis of Breast Cancer.
The Accumulation of Multiple Genetic Abnormalities in Individual Tumor Cells in Human Breast Cancers: Clinical Prognostic Implications
The breast cancer antigen 5T4 interacts with Rab11, and is a target and regulator of Rab11 mediated trafficking.
The calcium sensing receptor (CaSR) promotes Rab27B expression and activity to control secretion in breast cancer cells.
The caM kinase, Pnck, is spatially and temporally regulated during murine mammary gland development and may identify an epithelial cell subtype involved in breast cancer.
The catalytic class I(A) PI3K isoforms play divergent roles in breast cancer cell migration.
The E3-ligase E6AP Represses Breast Cancer Metastasis via Regulation of ECT2-Rho Signaling.
The H-ras oncogene product p21 and prognosis in human breast cancer.
The Jumonji Domain-Containing Histone Demethylase Homolog 1D/lysine Demethylase 7A (JHDM1D/KDM7A) Is an Epigenetic Activator of RHOJ Transcription in Breast Cancer Cells.
The R-Enantiomer of Ketorolac Delays Mammary Tumor Development in Mouse Mammary Tumor Virus-Polyoma Middle T Antigen (MMTV-PyMT) Mice.
The Rab2A GTPase promotes breast cancer stem cells and tumorigenesis via Erk signaling activation.
The Ras-related protein AGS1/RASD1 suppresses cell growth.
The Rho GTPase Cdc42 is required for primary mammary epithelial cell morphogenesis in vitro.
The Rho-specific guanine nucleotide exchange factor Dbs regulates breast cancer cell migration.
The secretory small GTPase Rab27B as a marker for breast cancer progression.
The Shp2-induced epithelial disorganization defect is reversed by HDAC6 inhibition independent of Cdc42.
The small GTPase ADP-Ribosylation Factor 1 mediates the sensitivity of triple negative breast cancer cells to EGFR tyrosine kinase inhibitors.
The small GTPase RhoA regulates the expression and function of the sodium channel Nav1.5 in breast cancer cells.
The V-ATPase-inhibitor Archazolid abrogates tumor metastasis via inhibition of endocytic activation of the Rho-GTPase Rac1.
The ZNF750-RAC1 axis as potential prognostic factor for breast cancer.
Therapeutic sensitivity to Rac GTPase inhibition requires consequential suppression of mTORC1, AKT, and MEK signaling in breast cancer.
Transcriptome-Wide Effects of Sphingosine Kinases Knockdown in Metastatic Prostate and Breast Cancer Cells: Implications for Therapeutic Targeting.
Transforming growth factor (TGF)-beta in conjunction with H-ras activation promotes malignant progression of MCF10A breast epithelial cells.
Triptolide Inhibits Breast Cancer Cell Metastasis Through Inducing the Expression of miR-146a, a Negative Regulator of Rho GTPase.
Update on the molecular profile of the MDA-MB-453 cell line as a model for apocrine breast carcinoma studies.
Use of molecular markers for predicting therapy response in cancer patients.
Vacuolar H+ ATPase expression and activity is required for Rab27B-dependent invasive growth and metastasis of breast cancer.
Vav proteins maintain epithelial traits in breast cancer cells using miR-200c-dependent and independent mechanisms.
Vimentin regulates EMT induction by Slug and oncogenic H-Ras and migration by governing Axl expression in breast cancer.
WNT-5A triggers Cdc42 activation leading to an ERK1/2 dependent decrease in MMP9 activity and invasive migration of breast cancer cells.
[Effects of Cdc42 overexpression on the estrogen-enhanced multidrug resistance in breast cancer cells].
[Genetic alterations in human malignant tumor]
[Let-7i reduces chemotherapy resistance in breast cancer cells through down-regulation of K-Ras and Bcl2 expression].
[Role of Rab23 in invasion and migration of human breast cancer Bcap-37 cells].
Brenner Tumor
Heterogeneous genetic alterations in ovarian mucinous tumors: application and usefulness of laser capture microdissection.
Bronchitis, Chronic
Detection of p53 and K-ras mutations in sputum of individuals exposed to smoky coal emissions in Xuan Wei County, China.
Burkholderia Infections
Immunospecific responses to bacterial elongation factor Tu during Burkholderia infection and immunization.
Carcinogenesis
A central role for Foxp3+ regulatory T cells in K-Ras-driven lung tumorigenesis.
A combinatorial approach for selectively inducing programmed cell death in human pancreatic cancer cells.
A comprehensive survey of Ras mutations in cancer.
A Conserved Role of IQGAP1 in Regulating TOR Complex 1.
A Cyp2a polymorphism predicts susceptibility to NNK-induced lung tumorigenesis in mice.
A detailed analysis of K-ras point mutations in relation to tumor progression and survival in colorectal cancer patients.
A label-free colorimetric isothermal cascade amplification for the detection of disease-related nucleic acids based on double-hairpin molecular beacon.
A mouse model for tumor progression of lung cancer in ras and p53 transgenic mice.
A Novel CDC42 Mutation in an 11-Year Old Child Manifesting as Syndromic Immunodeficiency, Autoinflammation, Hemophagocytic Lymphohistiocytosis, and Malignancy: A Case Report.
A novel high-specificity approach for colorectal neoplasia: Detection of K-ras2 oncogene mutation in normal mucosa.
A one-step DGGE scanning method for detection of mutations in the K-, N-, and H-ras oncogenes: mutations at codons 12, 13 and 61 are rare in B-cell non-Hodgkin's lymphoma.
A rapid PCR ELISA for the detection of activated K-ras in colorectal cancer.
A study of ras gene mutations in colonic adenomas from familial polyposis coli patients.
A subset of lung adenocarcinomas and atypical adenomatous hyperplasia-associated foci are genotypically related: an EGFR, HER2, and K-ras mutational analysis.
Abberant crypt foci -- importance in colorectal carcinogenesis and expression of p53 and mdm2: a changing concept.
Aberrant expression of miR-638 contributes to benzo(a)pyrene-induced human cell transformation.
Absence of H- and K-ras oncogene mutations in sporadic medullary thyroid carcinoma.
Absence of p53 mutations in methylnitrosourea-induced mammary tumors in rats.
Absence of point mutation in codons 12 and 13 of K-RAS oncogene in HPV-associated high grade dysplasia and squamous cell cervical carcinoma.
ACAP4 interacts with CrkII to promote the recycling of integrin ?1.
ACB-PCR measurement of K-ras codon 12 mutant fractions in livers of Big Blue rats treated with N-hydroxy-2-acetylaminofluorene.
ACB-PCR measurement of spontaneous and furan-induced H-ras Codon 61 CAA to CTA and CAA to AAA mutation in B6C3F1 mouse liver.
Activated Rac1 selectively up-regulates the expression of integrin alpha6beta4 and induces cell adhesion and membrane ruffles of nonadherent colon cancer Colo201 cells.
Activation of H-ras is prevalent in 1,3-butadiene-induced and spontaneously occurring murine Harderian gland tumors.
Activation of H-ras oncogenes in preneoplastic mouse mammary tissues.
Activation of K-ras in aflatoxin B1-induced lung tumors from AC3F1 (A/J x C3H/HeJ) mice.
Activation of Rap1 promotes prostate cancer metastasis.
Activator protein-1 activity regulates epithelial tumor cell identity.
Activin type II receptor restoration in ACVR2-deficient colon cancer cells induces transforming growth factor-beta response pathway genes.
Additional evidence that the K-ras protooncogene is a candidate for the major mouse pulmonary adenoma susceptibility (Pas-1) gene.
Aerosol delivery of lentivirus-mediated O-glycosylation mutant osteopontin suppresses lung tumorigenesis in K-ras (LA1) mice.
AKT and cancer--is it all mTOR?
Akt1 deletion prevents lung tumorigenesis by mutant K-ras.
Alteration of the k-ras gene expression in atypical and nonatypical hyperplastic endometrium.
Alterations in signal transduction pathways implicated in tumour progression during multistage mouse skin carcinogenesis.
Alterations of the K-ras and p53 genes in Tamoxifen-associated endometrial carcinoma.
Altered telomere homeostasis and resistance to skin carcinogenesis in Suv39h1 transgenic mice.
An attempt to isolate genes responsible for spontaneous and experimental metastasis in the mouse model.
Analysis of K-ras gene mutations in periampullary cancers, gallbladder cancers and cholangiocarcinomas from paraffin-embedded tissue sections.
Analysis of K-ras gene mutations in rare pancreatic and ampullary tumours.
Analysis of K-ras, APC, and beta-catenin in aberrant crypt foci in sporadic adenoma, cancer, and familial adenomatous polyposis.
Analysis of microsatellite instability, K-ras gene mutation and p53 protein overexpression in intrahepatic cholangiocarcinoma.
Anti-tumorigenic effect of a K-ras ribozyme against human lung cancer cell line heterotransplants in nude mice.
Antisense oligonucleotides specific to mutated K-ras genes inhibit invasiveness of human pancreatic cancer cell lines.
Antisera to the variable region of ras oncogene proteins, and specific detection of H-ras expression in an experimental model of chemical carcinogenesis.
Antitumorigenesis of antioxidants in a transgenic Rac1 model of Kaposi's sarcoma.
APC mutations are sufficient for the growth of early colorectal adenomas.
APC, K-ras codon 12 mutations and p53 gene expression in carcinoma and adenoma of the gall-bladder suggest two genetic pathways in gall-bladder carcinogenesis.
ARHGEF10L Promotes Cervical Tumorigenesis via RhoA-Mediated Signaling.
Aristolochic acid-induced carcinogenesis examined by ACB-PCR quantification of H-Ras and K-Ras mutant fraction.
Assessment of K-Ras mutant frequency and micronucleus incidence in the mouse duodenum following 90-days of exposure to Cr(VI) in drinking water.
Association between H-ras minisatellite and colorectal cancer risk.
Author Correction: The Rho GTPase Rnd1 suppresses mammary tumorigenesis and EMT by restraining Ras-MAPK signalling.
Avicins, a family of triterpenoid saponins from Acacia victoriae (Bentham), suppress H-ras mutations and aneuploidy in a murine skin carcinogenesis model.
B-Raf is dispensable for K-Ras-mediated oncogenesis in human cancer cells.
Bile duct cyst as precursor to biliary tract cancer.
Bmi-1 Cooperates with H-Ras to Transform Human Mammary Epithelial Cells via Dysregulation of Multiple Growth-Regulatory Pathways.
Both (+/-)syn- and (+/-)anti-7,12-dimethylbenz[a]anthracene-3,4-diol-1,2-epoxides initiate tumors in mouse skin that possess -CAA- to -CTA- mutations at Codon 61 of c-H-ras.
Both K-ras and H-ras protooncogene mutations are associated with Harderian gland tumorigenesis in B6C3F1 mice exposed to isoprene for 26 weeks.
BRAF mutations characterize colon but not gastric cancer with mismatch repair deficiency.
Brother's Keeper: Wild-Type Mutant K-Ras Dimers Limit Oncogenesis.
Cadmium modulates H-ras expression and caspase-3 apoptotic cell death in breast cancer epithelial MCF-7 cells.
Carcinogen exposure, p53 alteration, and K-ras mutation in synchronous multiple primary lung carcinoma.
Caveolin-1 is a novel regulator of K-RAS-dependent migration in colon carcinogenesis.
Cdc42 in oncogenic transformation, invasion, and tumorigenesis.
Cdc42 is involved in basal cell carcinoma carcinogenesis.
Cdc42 overexpression induces hyperbranching in the developing mammary gland by enhancing cell migration.
Cell Division Cycle 42 plays a Cell type-Specific role in Lung Tumorigenesis.
Cellular kinetics and gene mutations in gallbladder mucosa with an anomalous junction of pancreaticobiliary duct.
Cellular signaling for activation of Rho GTPase Cdc42.
Chemoprevention by pravastatin, a 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor, of N-methyl-N-nitrosourea-induced colon carcinogenesis in F344 rats.
Chemopreventive effect of perillyl alcohol on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induced tumorigenesis in (C3H/HeJ X A/J)F1 mouse lung.
Cholangiocarcinoma in primary sclerosing cholangitis: K-ras mutations and Tp53 dysfunction are implicated in the neoplastic development.
CircHIPK3 Promotes Thyroid Cancer Tumorigenesis and Invasion through the Mirna-338-3p/RAB23 Axis.
Circular RNA circSIPA1L1 Contributes to Osteosarcoma Progression Through the miR-411-5p/RAB9A Signaling Pathway.
Circulating miR-16-5p, miR-92a-3p, and miR-451a in Plasma from Lung Cancer Patients: Potential Application in Early Detection and a Regulatory Role in Tumorigenesis Pathways.
Clinical significance of K-ras and c-erbB-2 mutations in pancreatic adenocarcinoma and chronic pancreatitis.
Clinical significance of K-ras oncogene activation in ampullary neoplasms.
Clinicopathologic and carcinogenetic appraisal of DNA replication error in sporadic T3N0M0 stage colorectal cancer after curative resection.
Clinicopathological pattern and Annexin A2 and Cdc42 status in patients presenting with differentiation and lymphnode metastasis of esophageal squamous cell carcinomas.
Cloning and characterization of a novel Rab-family gene, Rab36, within the region at 22q11.2 that is homozygously deleted in malignant rhabdoid tumors.
Codon 12 region of mouse K-ras gene is the site for in vitro binding of transcription factors GATA-6 and NF-Y.
Coexistence of K-ras mutations and HPV infection in colon cancer.
Coincidental alterations of p16INK4A/CDKN2 and other genes in human lung cancer cell lines.
Colorectal carcinogenesis: historical review.
Combined identification of LncRNA CCAT1 and SOX2OT in serum as an effective screening for non-small cell lung cancer.
Combined Inactivation of MYC and K-Ras oncogenes reverses tumorigenesis in lung adenocarcinomas and lymphomas.
Combining clinicopathological predictors and molecular biomarkers in the oncogenic K-RAS/Ki67/HIF-1? pathway to predict survival in resectable pancreatic cancer.
Comethylation of p16 and MGMT genes in colorectal carcinoma: correlation with clinicopathological features and prognostic value.
Comparison of K-ras point mutations at codon 12 and p21 expression in pancreatic cancer between Japanese and Chinese patients.
Conditional expression of K-ras in an epithelial compartment that includes the stem cells is sufficient to promote squamous cell carcinogenesis.
Conditional expression of mutated K-ras accelerates intestinal tumorigenesis in Msh2-deficient mice.
Cooperation of oncogenic K-ras and p53 deficiency in pleomorphic rhabdomyosarcoma development in adult mice.
Cooperative induction of rat mammary cancer by radiation and 1-methyl-1-nitrosourea via the oncogenic pathways involving c-Myc activation and H-ras mutation.
Cooperativity of oncogenic K-ras and downregulated p16/INK4A in human pancreatic tumorigenesis.
Correlation of COX-2 and K-ras expression to clinical outcome in gastric cancer.
CpG island promoter hypermethylation of a novel Ras-effector gene RASSF2A is an early event in colon carcinogenesis and correlates inversely with K-ras mutations.
Crosstalk between Pten and Ras signaling pathways in tumor development.
Cucurbitacin I Inhibits Rac1 Activation in Breast Cancer Cells by a Ros-Mediated Mechanism and Independently of Jak2 and P-Rex1.
Curcumin Inhibits COPD-Like Airway Inflammation and Lung Cancer Progression in Mice.
Cyclin D1 over-expression correlates with beta-catenin activation, but not with H-ras mutations, and phosphorylation of Akt, GSK3 beta and ERK1/2 in mouse hepatic carcinogenesis.
Cyclin D1 overexpression in rat two-stage bladder carcinogenesis and its relationship with oncogenes, tumor suppressor genes, and cell proliferation.
Cytoskeletal modification of Rho guanine nucleotide exchange factor activity: identification of a Rho guanine nucleotide exchange factor as a binding partner for Sept9b, a mammalian septin.
Decrease in K-ras p21 and increase in Raf1 and activated Erk 1 and 2 in murine lung tumors initiated by N-nitrosodimethylamine and promoted by 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Deficiencies in mouse Myh and Ogg1 result in tumor predisposition and G to T mutations in codon 12 of the K-ras oncogene in lung tumors.
Deletion of Rap1b, but not Rap1a or Epac1, Reduces Protein Kinase A-Mediated Thyroid Cancer.
Depletion of K-Ras promotes proteasome degradation of survivin.
Detection of activated proto-oncogenes in N-nitrosodiethylamine-induced liver tumors: a comparison between B6C3F1 mice and Fischer 344 rats.
Detection of genetic alterations in the p53 suppressor gene and the K-ras oncogene among different grades of dysplasia in patients with colorectal adenomas.
Detection of high incidence of K-ras oncogenes during human colon tumorigenesis.
Detection of HPV and ras gene mutations in cervical smears from female genital lesions.
Detection of human papilloma virus (HPV) and K-ras mutations in human lung carcinomas.
Detection of K-ras mutations in pancreatic and hepatic neoplasms by non-isotopic mismatched polymerase chain reaction.
Detection of point mutations in the K-ras oncogene at codon 12 in pure pancreatic juice for diagnosis of pancreatic carcinoma.
Detection of ras oncogene point mutations and simultaneous proliferative fraction estimation in gallbladder cancer.
Detection of somatic DNA alterations in azoxymethane-induced F344 rat colon tumors by random amplified polymorphic DNA analysis.
Development of farnesyl transferase inhibitors: a review.
Diabetes and oral oncogenesis.
Diabetes enhances the expression of H-ras and suppresses the expression of EGFR leading to increased cell proliferation.
Diagnosis of pancreatic cancer by K-ras point mutation and cytology of pancreatic juice.
Diallyl sulfide enhances azoxymethane-induced preneoplasia in Fischer 344 rat colon.
Dietary supplementation of lutein reduces colon carcinogenesis in DMH-treated rats by modulating K-ras, PKB, and ?-catenin proteins.
Differences in carcinogenesis by the length of carcinogen exposure period in rat colon.
Differences in mucus and K-ras mutation in relation to phenotypes of tumors of the papilla of vater.
Differential expression and mutation of the ras family genes in human breast cancer.
Differential Expression of IL-17, 22 and 23 in the Progression of Colorectal Cancer in Patients with K-ras Mutation: Ras Signal Inhibition and Crosstalk with GM-CSF and IFN-?.
Differential involvement of RalA and RalB in colorectal cancer.
Differential roles of STAT3 in the initiation and growth of lung cancer.
Differential sensitivity of human colonic adenoma and carcinoma cells to transforming growth factor beta (TGF-beta): conversion of an adenoma cell line to a tumorigenic phenotype is accompanied by a reduced response to the inhibitory effects of TGF-beta.
Dipyridamole intervention of breast cell carcinogenesis.
Direct and Indirect Anticancer Activity of Plant-Derived Alkaloid Conophylline.
Distinct Binding Preferences between Ras and Raf Family Members and the Impact on Oncogenic Ras Signaling.
Distinct genetic profiles in colorectal tumors with or without the CpG island methylator phenotype.
DLC1 is unlikely to be a primary target for deletions on chromosome arm 8p22 in head and neck squamous cell carcinoma.
Dosage and allelic restriction fragment studies and PCR analysis of the H-ras locus in giant cell tumor of bone.
Down-regulated expression of RhoA in human conventional renal cell carcinoma.
Down-regulation of K-ras and H-ras in human brain gliomas.
DPC-4 (Smad-4) and K-ras gene mutations in biliary tract epithelium in children with anomalous pancreaticobiliary ductal union.
Dual phosphoinositide 3-kinase/mammalian target of rapamycin blockade is an effective radiosensitizing strategy for the treatment of non-small cell lung cancer harboring K-RAS mutations.
Ductal lesions in patients with chronic pancreatitis show K-ras mutations in a frequency similar to that in the normal pancreas and lack nuclear immunoreactivity for p53.
Dynamics of Ras complexes observed in living cells.
Early detection of cancer-associated gene alterations in DNA isolated from rat feces during intestinal tumor-induction with 1,2-dimethylhydrazine.
Effect of increased expression of both ras-related C3 botulinum toxin substrate 1 and p21-activated kinase 1 in patients with N0M0 upper urinary tract urothelial carcinoma and cancer-free surgical margins.
Effect of Jinguo Weikang Capsule () on proto-oncogene expression of gastric mucosa in rats with gastric precancerous lesions.
Effects of N-methyl-N'-nitro-N-nitrosoguanidine on the human colorectal polyps consecutively maintained in SCID mice.
Elevated IQGAP1 and CDC42 levels correlate with tumor malignancy of human glioma.
Elevated K-ras activity with cholestyramine and lovastatin, but not konjac mannan or niacin in lung--importance of mouse strain.
ELR+ CXC chemokines and oncogenic Ras-mediated tumorigenesis.
Endometrial carcinoma in a breast cancer patient treated with tamoxifen.
Endometrial K-ras mutations in postmenopausal breast cancer patients treated with adjuvant tamoxifen or toremifene.
Endothelin promotes colorectal tumorigenesis by activating YAP/TAZ.
Enhanced expression of Harvey-ras oncogene in FANFT-induced transitional cell carcinoma.
Enhancement of lung carcinogenesis initiated with 4-(N-hydroxymethylnitrosamino)-1-(3-pyridyl)-1-butanone by Ogg1 gene deficiency in female, but not male, mice.
Epidemiology of colorectal polyps.
Epidermal growth factor receptor and K-Ras in non-small cell lung cancer-molecular pathways involved and targeted therapies.
Epigenetic activation of the small GTPase TCL contributes to colorectal cancer cell migration and invasion.
Epithelial carcinogenesis in the mouse: correlating the genetics and the biology.
Epstein-Barr virus-encoded LMP1 interacts with FGD4 to activate Cdc42 and thereby promote migration of nasopharyngeal carcinoma cells.
Ets1 was significantly activated by ERK1/2 in mutant K-ras stably transfected human adrenocortical cells.
Eugenol restricts DMBA croton oil induced skin carcinogenesis in mice: downregulation of c-Myc and H-ras, and activation of p53 dependent apoptotic pathway.
Evaluation of genetic alterations in cancer-related genes in lung and brain tumors from B6C3F1 mice exposed to 1,3-butadiene or chloroprene.
Expression of activated M-Ras in a murine mammary epithelial cell line induces epithelial-mesenchymal transition and tumorigenesis.
Expression of Concern: Cooperativity of Oncogenic K-Ras and Downregulated p16/INK4A in Human Pancreatic Tumorigenesis.
Expression of epidermal growth factor receptor, but not K-RAS mutations, is present in congenital cystic airway malformation/congenital pulmonary airway malformation.
Expression of ets-1 is not affected by N-ras or H-ras during oral oncogenesis.
Expression of Hras-p21 and keratin K13 in UVR-induced skin tumors in Sencar mice.
Expression of oncogene products HER2/Neu and Ras and fibrosis-related growth factors bFGF, TGF-beta, and PDGF in bile from biliary malignancies and inflammatory disorders.
Expression of p21 ras protein as a prognostic factor in papillary thyroid cancer.
Expression profiles of pancreatic cancer cell lines infected with antisense K-ras-expressing adenoviral vector.
Extensive molecular tinkering in the evolution of the membrane attachment mode of the Rheb GTPase.
Failure of catalase to protect against aflatoxin B1-induced mouse lung tumorigenicity.
Fast repair of O6-ethylguanine, but not O6-methylguanine, in transcribed genes prevents mutation of H-ras in rat mammary tumorigenesis induced by ethylnitrosourea in place of methylnitrosourea.
FHIT and p53 gene abnormalities in bronchioloalveolar carcinomas. Correlations with clinicopathological data and K-ras mutations.
Fitness of unregulated human Ras mutants modeled by implementing computational mutagenesis and machine learning techniques.
Frequency and clinicopathology associations of K-ras mutations in colorectal cancer in a northeast Mexican population.
Frequency and spectrum of K-RAS codons 12 and 13 mutations in colorectal adenocarcinomas from Taiwan.
Frequency of H-ras mutations in human bladder cancer detected by direct sequencing.
Frequent and characteristic K-ras activation in aberrant crypt foci of colon. Is there preference among K-ras mutants for malignant progression?
Frequent c-Ha-ras gene mutations in rat mammary carcinomas induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.
Frequent involvement of ras-signalling pathways in both polypoid-type and flat-type early-stage colorectal cancers.
Frequent mutations of the p53 gene and infrequent H- and K-ras mutations in urinary bladder carcinomas of NON/Shi mice treated with N-butyl-N-(4-hydroxybutyl)nitrosamine.
FSH receptor binding inhibitor depresses carcinogenesis of ovarian cancer via decreasing levels of K-Ras, c-Myc and FSHR.
Galectin-8 binds to the Farnesylated C-terminus of K-Ras4B and Modifies Ras/ERK Signaling and Migration in Pancreatic and Lung Carcinoma Cells.
Gastric-type endocervical glandular neoplasms associated with aberrant p16 expression and K-RAS gene mutation in Peutz-Jeghers syndrome.
Gene mutations of K-ras in gallbladder mucosae and gallbladder carcinoma with an anomalous junction of the pancreaticobiliary duct.
Gene-environment interactions in the pre-Industrial Era: the cancer of King Ferrante I of Aragon (1431-1494).
Genetic alterations in ulcerative colitis-associated neoplasia focusing on APC, K-ras gene and microsatellite instability.
Genetic analysis of H-ras intron-1 polymorphic and variable tandem repeat regions in human breast cancer.
Genetic and cellular changes in colorectal cancer: proposed targets of chemopreventive agents.
Genetic and epigenetic alterations in colon cancer.
Genetic and epigenetic alterations in pancreatic carcinogenesis.
Genetic and epigenetic contributions to colorectal cancer.
Genetic changes in skin tumor progression: correlation between presence of a mutant ras gene and loss of heterozygosity on mouse chromosome 7.
Genetic evidence for an independent origin of multiple preneoplastic and neoplastic lung lesions.
Genetic instability in renal cell carcinoma.
Genomic instability and colon carcinogenesis: from the perspective of genes.
Genomic profiles of colorectal carcinoma with liver metastases and newly identified fusion genes.
Geranylgeranyltransferase I inhibitor GGTI-2154 induces breast carcinoma apoptosis and tumor regression in H-Ras transgenic mice.
Glucose-6-Phosphate Dehydrogenase Is Not Essential for K-Ras-Driven Tumor Growth or Metastasis.
Glutathione S-transferase-pi overexpression is closely associated with K-ras mutation during human colon carcinogenesis.
Growth inhibition of human pancreatic cancer cell lines by anti-sense oligonucleotides specific to mutated K-ras genes.
H-ras activation and ras p21 expression in bladder tumors induced in F344/NCr rats by N-butyl-N-(4-hydroxybutyl)nitrosamine.
H-ras activation in benign and self-regressing skin tumors (keratoacanthomas) in both humans and an animal model system.
H-ras activation is an early event in the ptaquiloside-induced carcinogenesis: comparison of acute and chronic toxicity in rats.
H-ras and c-fos exhibit similar expression patterns during most stages of oral oncogenesis.
H-ras codon 12 mutation in cervical dysplasia.
H-ras gene mutations in salivary gland mucoepidermoid carcinomas.
H-ras mutations in human pituitary carcinoma metastases.
H-ras oncogene mutation and human papillomavirus infection in oral carcinomas.
H-ras-1 point mutations in soft tissue sarcomas.
Harvey ras (H-ras) point mutations are induced by 4-nitroquinoline-1-oxide in murine oral squamous epithelia, while squamous cell carcinomas and loss of heterozygosity occur without additional exposure.
Hepatitis B Virus X Protein Stimulates Proliferation, Wound Closure and Inhibits Apoptosis of HuH-7 Cells via CDC42.
Hepatocellular Carcinomas in B6C3F1 Mice Treated with Ginkgo biloba Extract for Two Years Differ from Spontaneous Liver Tumors in Cancer Gene Mutations and Genomic Pathways.
Herbal bioactivation, molecular targets and the toxicity relevance.
Herbal bioactivation: the good, the bad and the ugly.
Heterozygous inactivation of TGF-beta1 increases the susceptibility to chemically induced mouse lung tumorigenesis independently of mutational activation of K-ras.
High frequency of activated K-ras codon 15 mutant in colorectal carcinomas from Taiwanese patients.
High frequency of K-ras mutations in biliary duct carcinomas of cases with a long common channel in the papilla of Vater.
High proportion of mutant K-ras gene in pancreatic juice of patients with pancreatic cystic lesions.
High susceptibility of human c-Ha-ras proto-oncogene transgenic rats to carcinogenesis: a cancer-prone animal model.
HIPK2 represses beta-catenin-mediated transcription, epidermal stem cell expansion, and skin tumorigenesis.
Histological and genetic changes in malignant transformation of gallbladder adenoma.
HLA molecules in basal cell carcinoma of the skin.
How do K-RAS-activated cells evade cellular defense mechanisms?
HPV mediated carcinogenesis: the role of k-ras mutations.
Human papillomavirus 16 (HPV16) enhances tumor growth and cancer stemness of HPV-negative oral/oropharyngeal squamous cell carcinoma cells via miR-181 regulation.
Human papillomavirus and colorectal cancer: evidences and pitfalls of published literature.
Human papillomavirus and mutated H-ras oncogene in cervical carcinomas and pathological negative pelvic lymph nodes: a retrospective follow-up.
Hyperglycemia promotes K-Ras-induced lung tumorigenesis through BASCs amplification.
Identification of a novel Rac3-interacting protein C1D.
Identification of secreted proteins that mediate cell-cell interactions in an in vitro model of the lung cancer microenvironment.
Identification of the Rac-GEF P-Rex1 as an essential mediator of ErbB signaling in breast cancer.
II. Effect of n-3 and n-6 fatty acids on mammary H-ras expression and PGE2 levels in DMBA-treated rats.
Immortalized bovine pancreatic duct cells become tumorigenic after transfection with mutant k-ras.
Immunohistochemical detection of RAS, JUN, FOS, and p53 oncoprotein expression in human colorectal adenomas and carcinomas.
Immunohistochemical evaluation of K-ras, p53, and HER-2/neu expression in hyperplastic, dysplastic, and carcinomatous lesions of the pancreas: evidence for multistep carcinogenesis.
Impact of Cellular Genetic Make-up on Colorectal Cancer Cell Lines Response to Ellagic Acid: Implications of Small Interfering RNA.
Impairing squamous differentiation by Klf4 deletion is sufficient to initiate tongue carcinoma development upon K-Ras activation in mice.
Implication of K-ras and p53 in colorectal cancer carcinogenesis in Tunisian population cohort.
In vitro carcinogenesis of hamster pancreatic duct cells: cellular and molecular alterations.
In vitro modeling of human pancreatic duct epithelial cell transformation defines gene expression changes induced by K-ras oncogenic activation in pancreatic carcinogenesis.
Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is associated with G to A mutations in K-ras in colorectal tumorigenesis.
Incidence of P53 and K-ras alterations in ovarian mucinous and serous tumors.
Increased expression of annexin A1 is correlated with K-ras mutation in colorectal cancer.
Increased H-ras mutation frequency in mammary tumors of rats initiated with N-methyl-N-nitrosourea (MNU) and treated with acrylamide.
Increased susceptibility of mice lacking Clara cell 10-kDa protein to lung tumorigenesis by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, a potent carcinogen in cigarette smoke.
Induction of apoptosis and inhibition of papilloma formation may signal a new role for okadaic acid.
Induction of invasive mouse skin carcinomas in transgenic mice with mutations in both H-ras and p53.
Induction of reactive oxygen species renders mutant and wild-type K-ras pancreatic carcinoma cells susceptible to Ad.mda-7-induced apoptosis.
Infrequent K-ras activation in superficial-type (flat) colorectal adenomas and adenocarcinomas.
Inhibition of activator protein 1 activity and cell growth by purified green tea and black tea polyphenols in H-ras-transformed cells: structure-activity relationship and mechanisms involved.
Inhibition of Cdc42 and Rac1 activities in pheochromocytoma, the adrenal medulla tumor.
Inhibition of CDC42 reduces macrophage recruitment and suppresses lung tumorigenesis in vivo.
Inhibition of COX-2 and induction of apoptosis: two determinants of nonsteroidal anti-inflammatory drugs' chemopreventive efficacies in mouse lung tumorigenesis.
Inhibition of HMGcoA reductase by atorvastatin prevents and reverses MYC-induced lymphomagenesis.
Inhibition of Rac1 reverses enzalutamide resistance in castration-resistant prostate cancer.
Inhibitors of farnesyl protein transferase and MEK1,2 induce apoptosis in fibroblasts transformed with farnesylated but not geranylgeranylated H-Ras.
Interaction between smoking and asbestos in human lung adenocarcinoma: role of K-ras mutations.
Interplay between estrogen and Stat3/NF-?B-driven immunomodulation in lung cancer.
Interplay between oncogenic K-Ras and wild-type H-Ras in Caco2 cell transformation.
Interrelationship between the expression of h-ras p21, C-myc and p53 proteins, and the infection of high-risk human papillomaviruses in Japanese patients with esophageal squamous-cell carcinoma.
Intratumor genetic heterogeneity in advanced human colorectal adenocarcinoma.
Intrinsic cooperation between p16INK4a and p21Waf1/Cip1 in the onset of cellular senescence and tumor suppression in vivo.
Involvement of APC and K-ras mutation in non-polypoid colorectal tumorigenesis.
Involvement of PLC?-PKC? pathway in human BIU-87 bladder cancer cell proliferation.
K-ras 4A and 4B mRNA levels correlate with superoxide in lung adenocarcinoma cells, while at the protein level, only mutant K-ras 4A protein correlates with superoxide.
K-ras activation generates an inflammatory response in lung tumors.
K-ras activation in colorectal tumors from patients with familial polyposis coli.
K-ras activation in gastric epithelial tumors in Japanese.
K-Ras and ?-catenin mutations cooperate with Fgfr3 mutations in mice to promote tumorigenesis in the skin and lung, but not in the bladder.
K-ras and p53 alterations in genomic DNA and transcripts of human pancreatic adenocarcinoma cell lines.
K-ras and p53 gene mutations in colorectal cancer in 57 Japanese patients.
K-ras and p53 gene mutations in pancreatic cancer: ductal and nonductal tumors progress through different genetic lesions.
K-ras and p53 in pancreatic cancer: association with medical history, histopathology, and environmental exposures in a population-based study.
K-ras and p53 mutations in aberrant crypt foci and colonic tumors from colon cancer patients.
K-ras and p53 mutations in human colorectal aberrant crypt foci.
K-ras and p53 mutations in stage I gallbladder carcinoma with an anomalous junction of the pancreaticobiliary duct.
K-ras and Wnt signaling synergize to accelerate prostate tumorigenesis in the mouse.
K-ras as a target for cancer therapy.
K-ras codon 12 mutation determines the polypoid growth of colorectral cancer.
K-ras exon 2 point mutations in human endometrial cancer.
K-ras gene mutation enhances motility of immortalized airway cells and lung adenocarcinoma cells via Akt activation: possible contribution to non-invasive expansion of lung adenocarcinoma.
K-ras gene mutations and loss of heterozygosity at the p53 gene locus relative to histological characteristics of mucin-producing tumors of the pancreas.
K-ras gene mutations in intrahepatic bile duct tumors of Syrian golden hamsters.
K-ras gene mutations in normal colorectal tissues from K-ras mutation-positive colorectal cancer patients.
K-ras gene point mutation in neogenetic lesions of subpleural fibrotic lesions: either an early genetic event in lung cancer development or a non-specific genetic change during the inflammatory reparative process.
K-Ras gene status and expression of Ras/mitogen-activated protein kinase (MAPK) signaling molecules in ameloblastomas.
K-Ras Lys-42 is crucial for its signaling, cell migration, and invasion.
K-Ras mediated murine epidermal tumorigenesis is dependent upon and associated with elevated Rac1 activity.
K-ras mutation and p53 protein accumulation in intraductal mucin-hypersecreting neoplasms of the pancreas.
K-ras mutation in helicobacter pylori-associated chronic gastritis in patients with and without gastric cancer.
K-RAS mutation in transitional cell carcinoma of urinary bladder.
K-ras mutation is an early event in pancreatic duct carcinogenesis in the Syrian golden hamster.
k-ras mutation may be an early event in mucinous ovarian tumorigenesis.
K-ras mutation may promote carcinogenesis of endometriosis leading to ovarian clear cell carcinoma.
K-ras mutations and cell kinetics in Helicobacter pylori associated gastric intestinal metaplasia: a comparison before and after eradication in patients with chronic gastritis and gastric cancer.
K-ras mutations and HLA-DR expression in large bowel adenomas.
K-ras mutations and mucin profile in preneoplastic lesions and colon tumors induced in rats by 1,2-dimethylhydrazine.
K-ras mutations and prognosis in large-bowel carcinomas.
K-ras mutations appear in the premalignant phase of both microsatellite stable and unstable endometrial carcinogenesis.
K-ras mutations are a relatively late event in the pathogenesis of lung carcinomas.
K-ras Mutations as the Earliest Driving Force in a Subset of Colorectal Carcinomas.
K-ras mutations in 1,2-dimethylhydrazine-induced colonic tumors: effects of supplemental dietary calcium and vitamin D deficiency.
K-ras mutations in aberrant crypt foci, adenomas and adenocarcinomas during azoxymethane-induced colon carcinogenesis.
K-ras mutations in colorectal cancer: a practice changing discovery.
K-ras mutations in incident sporadic colorectal adenomas.
K-ras mutations in lung tumors and tumors from other organs are consistent with a common mechanism of ethylene oxide tumorigenesis in the B6C3F1 mouse.
K-ras mutations in lung tumors from A/J and A/J x TSG-p53 F1 mice treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and phenethyl isothiocyanate.
K-ras Mutations in Lung Tumors from NNK-treated Mice with Lipopolysaccharide-elicited Lung Inflammation.
K-ras mutations in lung tumors from p53 mutant mice exposed to cigarette smoke.
K-ras mutations in mouse lung tumors of extreme age: independent of paternal preconceptional exposure to chromium(III) but significantly more frequent in carcinomas than adenomas.
K-ras mutations in mucinous ovarian tumors: a clinicopathologic and molecular study of 95 cases.
K-ras mutations in putative preneoplastic lesions in human colon.
K-ras mutations, rectal crypt cells proliferation, and meat consumption in patients with left-sided colorectal carcinoma.
K-ras oncogene mutation in cancer and precancerous lesions of the gallbladder.
K-ras oncogene mutation in pterygium.
K-ras oncogene mutations in sporadic colorectal cancer in The Netherlands Cohort Study.
K-ras point mutation is associated with enhancement by deoxycholic acid of colon carcinogenesis induced by azoxymethane, but not with its attenuation by all-trans-retinoic acid.
K-ras point mutation occurs in the early stage of carcinogenesis in lung cancer.
K-RAS point mutation, and amplification of C-MYC and C-ERBB2 in colon adenocarcinoma.
K-ras point mutations in cancerous and noncancerous biliary epithelium in patients with pancreaticobiliary maljunction.
K-ras point mutations in endometrial carcinoma: effect on outcome is dependent on age of patient.
K-ras point mutations in spontaneously occurring endometrial adenocarcinomas in the Donryu rat.
K-Ras Promotes Tumorigenicity through Suppression of Non-canonical Wnt Signaling.
K-ras proto-oncogene exhibits tumor suppressor activity as its absence promotes tumorigenesis in murine teratomas.
K-ras role in lung cancer therapy.
K-Ras stabilization by estrogen via PKC? is involved in endometrial tumorigenesis.
K-Ras-Activated Cells Can Develop into Lung Tumors When Runx3-Mediated Tumor Suppressor Pathways Are Abrogated.
KLF4 regulates adult lung tumor-initiating cells and represses K-Ras-mediated lung cancer.
KRAS: From undruggable to a druggable Cancer Target.
KY1022, a small molecule destabilizing Ras via targeting the Wnt/?-catenin pathway, inhibits development of metastatic colorectal cancer.
Large Bowel Genetic Background and Inflammatory Processes in Carcinogenesis--Systematic Review.
Lessons learned from colorectal model of tumourigenesis.
Levels and membrane localization of the c-K-ras p21 protein in lungs of mice of different genetic strains and effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and Aroclor 1254.
Life-span inhalation exposure to mainstream cigarette smoke induces lung cancer in B6C3F1 mice through genetic and epigenetic pathways.
Lifetime history of alcohol consumption and K-ras mutations in pancreatic ductal adenocarcinoma.
Lin28 promotes transformation and is associated with advanced human malignancies.
Long-term follow-up of patients with a clinically benign extrahepatic biliary stenosis and K-ras mutation in endobiliary brush cytology.
Loss of Apc allows phenotypic manifestation of the transforming properties of an endogenous K-ras oncogene in vivo.
Loss of growth control by TGF-beta occurs at a late stage of mouse skin carcinogenesis and is independent of ras gene activation.
Loss of heterozygosity and K-ras gene mutations in gastric cancer.
Loss of p27Kip¹ promotes metaplasia in the pancreas via the regulation of Sox9 expression.
Loss of the novel tumour suppressor and polarity gene Trim62 (Dear1) synergizes with oncogenic Ras in invasive lung cancer.
Low somatic K-ras mutation frequency in colorectal cancer diagnosed under the age of 45 years.
LPS-induced nuclear translocation of RhoA is dependent on NF-?B in the human lung cancer cell line A549.
M-Ras induces Ral and JNK activation to regulate MEK/ERK-independent gene expression in MCF-7 breast cancer cells.
Malignant transformation of immortalized human bronchial epithelial cells by asbestos fibers.
Map kinase activation correlates with K-ras mutation and loss of heterozygosity on chromosome 6 in alveolar bronchiolar carcinomas from B6C3F1 mice exposed to vanadium pentoxide for 2 years.
Mechanism of bracken fern carcinogenesis: evidence for H-ras activation via initial adenine alkylation by ptaquiloside.
Melphalan inhibits adenoma development through modulating the expression of K-ras-specific markers in K-ras Tg mice.
Metabolic activation of herbal and dietary constituents and its clinical and toxicological implications: an update.
Metastasis is driven by sequential elevation of H-ras and Smad2 levels.
Metastasis suppressors Nm23H1 and Nm23H2 differentially regulate neoplastic transformation and tumorigenesis.
Methods for investigating G-quadruplex DNA/ligand interactions.
Micro ribonucleic acid-93 promotes oncogenesis of cervical cancer by targeting RAB11 family interacting protein 1.
Microarray-based copy number analysis of neurofibromatosis type-1 (NF1)-associated malignant peripheral nerve sheath tumors reveals a role for Rho-GTPase pathway genes in NF1 tumorigenesis.
MicroRNA-31 inhibits RhoA-mediated tumor invasion and chemotherapy resistance in MKN-45 gastric adenocarcinoma cells.
Microsatellite and EGFR, HER2 and K-RAS analyses in sclerosing hemangioma of the lung.
Microvessel density, cyclo-oxygenase 2 expression, K-ras mutation and p53 overexpression in colonic cancer.
Minireview: Mouse Models of Rho GTPase Function in Mammary Gland Development, Tumorigenesis, and Metastasis.
miR-124 Inhibits Lung Tumorigenesis Induced by K-ras Mutation and NNK.
miR-124-3p acts as a potential marker and suppresses tumor growth in gastric cancer.
miR-200b/c-RAP1B axis represses tumorigenesis and malignant progression of papillary thyroid carcinoma through inhibiting the NF-?B/Twist1 pathway.
MiroRNA-188 Acts as Tumor Suppressor in Non-Small-Cell Lung Cancer by Targeting MAP3K3.
Molecular and biological analysis of carcinoma of the small intestine: beta-catenin gene mutation by interstitial deletion involving exon 3 and replication error phenotype.
Molecular and immunohistochemical analysis of intraductal papillary neoplasms of the biliary tract.
Molecular carcinogenesis of endometrial cancer.
Molecular changes in the early stage of colon carcinogenesis in rats treated with azoxymethane.
Molecular characterisation of pancreatic ductal adenocarcinoma in patients under 40.
Molecular characterisation of the small GTPase CDC42 in the ectomycorrhizal fungus Tuber borchii Vittad.
Molecular determinants of dysplasia in colorectal lesions.
Molecular dynamics simulations of Gly-12-->Val mutant of p21(ras): dynamic inhibition mechanism.
Molecular genetic changes associated with colorectal carcinogenesis are not prognostic for tumor regression following preoperative chemoradiation of rectal carcinoma.
Molecular genetic characterization of BRCA1- and BRCA2-linked hereditary ovarian cancers.
Molecular genetics and cellular events of K-Ras-driven tumorigenesis.
Molecular mechanisms underlying the tumorigenesis of colorectal adenomas: correlation to activated K-ras oncogene.
Molecular pathogenesis of endometriosis-associated clear cell carcinoma of the ovary (review).
Molecular pathology of invasive carcinoma.
Molecular profiling of chordoma.
Molecular screening for somatic mutations in corticotropic adenomas of dogs with pituitary-dependent hyperadrenocorticism.
Morphologic change and elevation of cortisol secretion in cultured human normal adrenocortical cells caused by mutant p21K-ras protein.
Mouse mammary tumor virus/v-Ha-ras transgene-induced mammary tumors exhibit strain-specific allelic loss on mouse chromosome 4.
Mouse model for lung tumorigenesis through Cre/lox controlled sporadic activation of the K-Ras oncogene.
Multiple genetic alterations in hamster pancreatic ductal adenocarcinomas.
Multistep carcinogenesis in colorectal cancers.
Murine models of colorectal cancer: studying the role of oncogenic K-ras.
Murine squamous cell carcinoma cell lines produced by a complete carcinogenesis protocol with benzo[a]pyrene exhibit characteristic p53 mutations and the absence of H-ras and cyl 1/cyclin D1 abnormalities.
Mutant K-ras in apparently normal mucosa of colorectal cancer patients. Its potential as a biomarker of colorectal tumorigenesis.
Mutant K-ras promotes carcinogen-induced murine colorectal tumourigenesis, but does not alter tumour chromosome stability.
Mutant KRAS in the initiation of pancreatic cancer.
Mutated K-ras(Asp12) promotes tumourigenesis in Apc(Min) mice more in the large than the small intestines, with synergistic effects between K-ras and Wnt pathways.
Mutation of beta-catenin does not coexist with K-ras mutation in colorectal tumorigenesis.
Mutation of p53 and K-ras, and loss of heterozygosity of APC in intrahepatic cholangiocarcinoma.
Mutation of the nm23 gene, loss of heterozygosity at the nm23 locus and K-ras mutation in ovarian carcinoma: correlation with tumour progression and nm23 gene expression.
Mutational analysis of the BRAF gene in colorectal mucinous carcinoma in association with histological configuration.
Mutational and epigenetic evidence for independent pathways for lung adenocarcinomas arising in smokers and never smokers.
Mutational and nonmutational activation of p21ras in rat colonic azoxymethane-induced tumors: effects on mitogen-activated protein kinase, cyclooxygenase-2, and cyclin D1.
Mutational spectrum of K-ras oncogene among Indian patients with gallbladder cancer.
Mutationally activated K-ras 4A and 4B both mediate lung carcinogenesis.
Mutations in an alternatively spliced exon of h-ras are not associated with loss of heterozygosity on chromosome 11p15.5 in ovarian tumorigenesis.
Mutations in ras genes in experimental tumours of rodents.
Mutations in the K-ras oncogene induced by 1,2-dimethylhydrazine in preneoplastic and neoplastic rat colonic mucosa.
Mutations in the phosphatidylinositol-3-kinase pathway predict for antitumor activity of the inhibitor PX-866 whereas oncogenic Ras is a dominant predictor for resistance.
Mutations of K-ras oncogene and absence of H-ras mutations in squamous cell carcinomas of the lung.
Mutations of p53 and K-ras correlate TF expression in human colorectal carcinomas: TF downregulation as a marker of poor prognosis.
Nanobody-Based Quantification of GTP-Bound RHO Conformation Reveals RHOA and RHOC Activation Independent from Their Total Expression in Breast Cancer.
Neoplastic transformation of rat colon epithelial cells by expression of activated human K-ras.
NF-kappa B is required for H-ras oncogene induced abnormal cell proliferation and tumorigenesis.
Nitrative and oxidative DNA damage caused by K-ras mutation in mice.
NMR 1H,13C, 15N backbone and 13C side chain resonance assignment of the G12C mutant of human K-Ras bound to GDP.
No major difference in K-ras and p53 abnormalities in sporadic and hereditary nonpolyposis colorectal adenomas.
No occurrence of DNA-polymerase Beta-gene mutation in human lung-carcinoma cell-lines with k-ras as, p53, or rb gene alterations.
Non-covalent interactions of the carcinogen (+)-anti-BPDE with exon 1 of the human K-ras proto-oncogene.
Non-involvement of the K-ras mutation in colon carcinogenesis promoted by dietary deoxycholate in azoxymethane-treated rats.
Notch1 functions as a tumor suppressor in a model of K-ras-induced pancreatic ductal adenocarcinoma.
Novel approach to abuse the hyperactive K-Ras pathway for adenoviral gene therapy of colorectal cancer.
Novel targeting approaches and signaling pathways of colorectal cancer: An insight.
Nrf2 promotes mutant K-ras/p53-driven pancreatic carcinogenesis.
Nuclear beta-catenin expression is closely related to ulcerative growth of colorectal carcinoma.
Nuclear factor-?B signaling pathway is involved in phospholipase C?-regulated proliferation in human renal cell carcinoma cells.
Nullifying the CDKN2A/B Locus Promotes Mutant K-ras Lung Tumorigenesis.
O-linked GlcNAcylation elevated by HPV E6 mediates viral oncogenesis.
Occurrence of mutations in the epidermal growth factor receptor gene in X-ray-induced rat lung tumors.
Oct4 and Nanog Expression Is Associated With Early Stages of Pancreatic Carcinogenesis.
Oncogenesis and the Clinical Significance of K-ras in Pancreatic Adenocarcinoma.
Oncogenic K-Ras decouples glucose and glutamine metabolism to support cancer cell growth.
Oncogenic K-ras drives cell cycle progression and phenotypic conversion of primary pancreatic duct epithelial cells.
Oncogenic K-ras promotes early carcinogenesis in the mouse proximal colon.
Oncogenic K-Ras signals through epidermal growth factor receptor and wild-type H-Ras to promote radiation survival in pancreatic and colorectal carcinoma cells.
Oncosuppressor methylation: A possible key role in colon metastatic progression.
p14ARF promoter hypermethylation in plasma DNA as an indicator of disease recurrence in bladder cancer patients.
p21-Activated protein kinases and their emerging roles in glucose homeostasis.
p38MAPK builds a hyaluronan cancer niche to drive lung tumorigenesis.
p53 and H-ras mutations and microsatellite instability in renal pelvic carcinomas of NON / Shi mice treated with N-butyl-N-(4-hydroxybutyl)-nitrosamine: different genetic alteration from urinary bladder carcinoma.
p53 and ras gene expression in human esophageal cancer and Barrett's epithelium: a prospective study.
p53 mutations and tetraploids under r- and K-selection.
p53 mutations in early neoplastic lesions of the urinary bladder in rats treated with N-butyl-N-(4-hydroxybutyl)nitrosamine.
p53 mutations in transitional cell carcinomas of the urinary bladder in rats treated with N-butyl-N-(4-hydroxybutyl)-nitrosamine.
Past medical conditions and K-ras mutations in pancreatic ductal adenocarcinoma: a hypothesis-generating study.
Pathology and proliferative activity of renal-cell carcinomas (RCCS) and renal oncocytomas in patients with different radiation exposure after the Chernobyl accident in Ukraine.
Peroxisome proliferator-activated receptor gamma and spermidine/spermine N1-acetyltransferase gene expressions are significantly correlated in human colorectal cancer.
Phenotypic classification of gastric signet ring cell carcinoma and its relationship with K-ras mutation.
Phosphorylation-induced conformational changes in Rap1b: allosteric effects on switch domains and effector loop.
Plk4 is required for cytokinesis and maintenance of chromosomal stability.
Polychlorinated biphenyls promote 1-nitropyrene-induced lung tumorigenesis without the induction of K-ras gene mutation in A/J mice.
Polypoid growth and K-ras codon 12 mutation in colorectal cancer.
Predominance of G to A codon 12 mutation K-ras gene in Dukes' B colorectal cancer.
Predominant K-ras codon 12 G --> A transition in chemically induced lung neoplasms in B6C3F1 mice.
Prevalence of activating K-ras mutations in the evolutionary stages of neoplasia in intraductal papillary mucinous tumors of the pancreas.
Prevention of lung cancer progression by bexarotene in mouse models.
Prognostic significance of immunohistochemical RhoA expression on survival in pancreatic ductal adenocarcinoma: a high-throughput analysis.
Prognostic Significance of K- ras Codon 12 Mutation in Patients with Resected Gallbladder Cancer.
Progress and challenges in selected areas of tobacco carcinogenesis.
Proline isomerisation as a novel regulatory mechanism for p38MAPK activation and functions.
Prolonged sulforaphane treatment does not enhance tumorigenesis in oncogenic K-ras and xenograft mouse models of lung cancer.
Promoter methylation of RASSF1A and DAPK and mutations of K-ras, p53, and EGFR in lung tumors from smokers and never-smokers.
Promoting effect of a high-fat/high-protein diet in DMBA-induced ductal pancreatic cancer in rats.
Promotion of Lung Carcinogenesis by COPD-like Airway Inflammation in a K-ras Induced Mouse Model.
Pten inactivation accelerates oncogenic K-ras-initiated tumorigenesis in a mouse model of lung cancer.
PTEN loss and activation of K-RAS and ?-catenin cooperate to accelerate prostate tumourigenesis.
Rab13 regulates sEV secretion in mutant KRAS colorectal cancer cells.
RAB18 promotes proliferation and metastasis in hepatocellular carcinoma.
Rab23 and developmental disorders.
Rab33A: Characterization, Expression, and Suppression by Epigenetic Modification.
Rab35 GTPase and cancer: Linking membrane trafficking to tumorigenesis.
Ral small GTPase signaling and oncogenesis: More than just 15minutes of fame.
Ral: mediator of membrane trafficking.
RalA mediates v-Src, v-Ras, and v-Raf regulation of CD44 and fibronectin expression in NIH3T3 fibroblasts.
RalA regulates vascular endothelial growth factor-C (VEGF-C) synthesis in prostate cancer cells during androgen ablation.
Rap1A promotes ovarian cancer metastasis via activation of ERK/p38 and notch signaling.
Rapamycin Prevents Early Onset of Tumorigenesis in an Oral-Specific K-ras and p53 Two-Hit Carcinogenesis Model.
Ras gene mutation is not related to tumour invasion during rat tongue carcinogenesis induced by 4-nitroquinoline 1-oxide.
ras gene mutations in salivary gland tumors.
Ras gene point mutations in gallbladder lesions associated with anomalous connection of pancreatobiliary ducts.
ras induced lesions in a heterotopic mouse bladder.
Ras regulation of DNA-methylation and cancer.
Ras signaling in aging and metabolic regulation.
Reactive oxygen species and lung tumorigenesis by mutant K-ras: a working hypothesis.
Recent advances in understanding the antineoplastic mechanisms of farnesyltransferase inhibitors.
Reduced cell death, invasive and angiogenic features conferred by BRCA1-deficiency in mammary epithelial cells transformed with H-Ras.
Reduced lung tumorigenesis in human methylguanine DNA--methyltransferase transgenic mice achieved by expression of transgene within the target cell.
Reduction of pp32 expression in poorly differentiated pancreatic ductal adenocarcinomas and intraductal papillary mucinous neoplasms with moderate dysplasia.
Regulation and functional significance of CDC42 alternative splicing in ovarian cancer.
Regulation of proto-oncogene transcription, cell proliferation, and tumorigenesis in mice by PSF protein and a VL30 noncoding RNA.
Relation between K-ras codon 12 mutation and p53 protein overexpression in gallbladder cancer and biliary ductal epithelia in patients with pancreaticobiliary maljunction.
Relationship of the K-ras/c-mos expression patterns with angiogenesis in non-small cell lung carcinomas.
Relationships of DNA adduct formation, K-ras activating mutations and tumorigenic activities of 6-nitrochrysene and its metabolites in the lungs of CD-1 mice.
Remodeling cancer stemness by collagen/fibronectin via the AKT and CDC42 signaling pathway crosstalk in glioma.
Remote partial gastrectomy as a risk factor for pancreatic cancer: potential for preventive strategies.
Requirement for Rac1 in a K-ras induced lung cancer in the mouse.
Requirement of the NF-kappaB subunit p65/RelA for K-Ras-induced lung tumorigenesis.
Restoration of mutant K-Ras repressed miR-199b inhibits K-Ras mutant non-small cell lung cancer progression.
Restored expression of transforming growth factor beta type II receptor in k-ras-transformed thyroid cells, TGF beta-resistant, reverts their malignant phenotype.
Retinoblastoma protein (pRB) was significantly phosphorylated through a Ras-to-MAPK pathway in mutant K-ras stably transfected human adrenocortical cells.
Reversal of the malignant phenotype of gastric cancer cells by inhibition of RhoA expression and activity.
Rho Family GTPase modification and dependence on CAAX motif-signaled posttranslational modification.
Rho GTPase Activating Protein 24 (ARHGAP24) Silencing Promotes Lung Cancer Cell Migration and Invasion by Activating ?-Catenin Signaling.
Rho GTPase Activating Protein 9 (ARHGAP9) in Human Cancers.
Rho GTPase expression in tumourigenesis: evidence for a significant link.
Rho GTPase function in tumorigenesis.
Rho?associated kinase inhibitor, Y?27632, inhibits the invasion and proliferation of T24 and 5367 bladder cancer cells.
RhoE is frequently downregulated in HCC and suppresses HCC invasion through antagonizing the Rho/ROCK/MYPT pathway.
RhoGTPases and their role in cancer.
Rnd3 in Cancer: a Review of the Evidence for Tumor Promoter or Suppressor.
ROCK and nuclear factor-kappaB-dependent activation of cyclooxygenase-2 by Rho GTPases: effects on tumor growth and therapeutic consequences.
Role of DNA methylation in the activation of proto-oncogenes and the induction of pulmonary neoplasia by nitrosamines.
Role of epidermal growth factor receptor overexpression, K-ras point mutation and c-myc amplification in the carcinogenesis of non-small cell lung cancer.
Role of oncogenic K-Ras in cancer stem cell activation by aberrant Wnt/?-catenin signaling.
Role of point mutation of the K-ras gene in tumorigenesis of B6C3F1 mouse lung lesions induced by urethane.
Role of tumour markers, cytogenetics.
Runx3 is required for the differentiation of lung epithelial cells and suppression of lung cancer.
Senescence in pancreatic carcinogenesis: from signalling to chromatin remodelling and epigenetics.
Sex specific function of epithelial STAT3 signaling in pathogenesis of K-ras mutant lung cancer.
Similar incidence of K-ras mutations in lung carcinomas of FVB/N mice and FVB/N mice carrying a mutant p53 transgene.
Sirt1 protects from K-Ras-driven lung carcinogenesis.
Small molecule inhibition of group I p21-activated kinases in breast cancer induces apoptosis and potentiates the activity of microtubule stabilizing agents.
Somatic APC and K-ras codon 12 mutations in periampullary adenomas and carcinomas from familial adenomatous polyposis patients.
Spatial control of Cdc42 signalling by a GM130-RasGRF complex regulates polarity and tumorigenesis.
Specific codon 13 K-ras mutations are predictive of clinical outcome in colorectal cancer patients, whereas codon 12 K-ras mutations are associated with mucinous histotype.
Sprouty-2 regulates oncogenic K-ras in lung development and tumorigenesis.
Stem cell gene expression changes induced specifically by mutated K-ras.
Stimulated human leukocytes cause activating mutations in the K-ras protooncogene.
Studies on clinicopathological features of lung cancer patients with K-ras/p53 gene alterations: comparison between younger and older groups.
Studies on ras oncogene activation in endometrial carcinoma.
Study of the correlation between H-ras mutation and primary hepatocellular carcinoma.
Suppression of colorectal oncogenesis by selenium-enriched milk proteins: apoptosis and K-ras mutations.
Suppression of skin tumorigenesis in CD109-deficient mice.
SVR angiosarcomas can be rejected by CD4 costimulation dependent and CD8 costimulation independent pathways.
Synergism between K-rasVal12 and mutant Apc accelerates murine large intestinal tumourigenesis.
Synergistic effect of MNU and DMBA in mammary carcinogenesis and H-ras activation in female Sprague-Dawley rats.
Systemic activation of K-ras rapidly induces gastric hyperplasia and metaplasia in mice.
Targeted deletion of RasGRP1 impairs skin tumorigenesis.
Targeted deletion of the H-ras gene decreases tumor formation in mouse skin carcinogenesis.
Targeted expression of oncogenic K-ras in intestinal epithelium causes spontaneous tumorigenesis in mice.
Targeting Cdc42 in cancer.
Targeting Lactate Dehydrogenase-A Inhibits Tumorigenesis and Tumor Progression in Mouse Models of Lung Cancer and Impacts Tumor-Initiating Cells.
Targeting p21-activated kinase 1 (PAK1) to induce apoptosis of tumor cells.
Targeting the Ras-ERK pathway in pancreatic adenocarcinoma.
Tea polyphenols can restrict benzo[a]pyrene-induced lung carcinogenesis by altered expression of p53-associated genes and H-ras, c-myc and cyclin D1.
Telomeric repeat-length alterations in colorectal carcinoma are associated with loss of heterozygosity and point mutation in p53 gene.
Temporal dissection of K-ras(G12D) mutant in vitro and in vivo using a regulatable K-ras(G12D) mouse allele.
The activation of K-ras gene at an early stage of lung tumorigenesis in mice.
The alternative H-ras protein p19 displays properties of a negative regulator of p21Ras.
The cancer-associated, gain-of-function TP53 variant P152Lp53 activates multiple signaling pathways implicated in tumorigenesis.
The cell cycle regulator Ecdysoneless cooperates with H-Ras to promote oncogenic transformation of human mammary epithelial cells.
The detection of chemically initiated cells having the mutation of K-ras gene at an early stage of lung carcinogenesis in mice.
The deubiquitinase USP16 functions as an oncogenic factor in K-RAS-driven lung tumorigenesis.
The dual functions of Rab11 and Rab35 GTPases-regulation of cell division and promotion of tumorigenicity.
The E6 oncoproteins of high-risk papillomaviruses bind to a novel putative GAP protein, E6TP1, and target it for degradation.
The effect of a 2-h exposure to cigarette smoke on the metabolic activation of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in A/J mice.
The effect of cotinine or cigarette smoke co-administration on the formation of O6-methylguanine adducts in the lung and liver of A/J mice treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)
The frequency and spectrum of K-ras mutations among Iraqi patients with sporadic colorectal carcinoma.
The Galpha12/13 family of heterotrimeric G proteins and the small GTPase RhoA link the Kaposi sarcoma-associated herpes virus G protein-coupled receptor to heme oxygenase-1 expression and tumorigenesis.
The hamster model of sequential oral oncogenesis.
The inhibitory effect of vitamin E on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced DNA injury and the fixation of the DNA injury in mouse lungs.
The inhibitory effect of vitamin E on K-ras mutation at an early stage of lung carcinogenesis in mice.
The lichen secondary metabolite atranorin suppresses lung cancer cell motility and tumorigenesis.
The LIM-domain only protein 4 contributes to lung epithelial cell proliferation but is not essential for tumor progression.
The Long Intergenic Noncoding RNA 00707 Promotes Lung Adenocarcinoma Cell Proliferation and Migration by Regulating Cdc42.
The mucin MUC4 is a transcriptional and post-transcriptional target of K-ras oncogene in pancreatic cancer. Implication of MAPK/AP-1, NF-?B and RalB signaling pathways.
The mutant K-ras oncogene causes pancreatic periductal lymphocytic infiltration and gastric mucous neck cell hyperplasia in transgenic mice.
The nuclear factor-kappa B RelA transcription factor is constitutively activated in human pancreatic adenocarcinoma cells.
The p53 inhibitor Mdm4 cooperates with multiple genetic lesions in tumourigenesis.
The presence of Merkel cell polyomavirus is associated with deregulated expression of BRAF and Bcl-2 genes in non-small cell lung cancer.
The pro-apoptotic K-Ras 4A proto-oncoprotein does not affect tumorigenesis in the ApcMin/+ mouse small intestine.
The Rab2A GTPase promotes breast cancer stem cells and tumorigenesis via Erk signaling activation.
The Rho GTPase Rnd1 suppresses mammary tumorigenesis and EMT by restraining Ras-MAPK signalling.
The RND1 Small GTPase: Main Functions and Emerging Role in Oncogenesis.
The role of ras gene mutation in gastric cancer and precancerous lesions.
The role of ras GTPase activating protein in human tumorigenesis.
The role of the small GTPase Rab31 in cancer.
The sequential accumulation of genetic alterations characteristic of the colorectal adenoma-carcinoma sequence does not occur between gastric adenoma and adenocarcinoma.
The Significance of Ras Activity in Pancreatic Cancer Initiation.
The Synergistic Effect of Conditional Pten Loss and Oncogenic K-ras Mutation on Endometrial Cancer Development Occurs via Decreased Progesterone Receptor Action.
The TGF-{beta} co-receptor endoglin modulates the expression and transforming potential of H-Ras.
The ubiquitin-proteasome system in colorectal cancer.
Therapeutic modulation of k-ras signaling in colorectal cancer.
Tobacco smoke-induced lung tumorigenesis in mutant A/J mice with alterations in K-ras, p53, or Ink4a/Arf.
Transfection of K-rasAsp12 cDNA markedly elevates IL-1beta- and lipopolysaccharide-mediated inducible nitric oxide synthase expression in rat intestinal epithelial cells.
Transforming growth factor-?-stimulated clone-22 is a negative-feedback regulator of Ras?/?Raf signaling: Implications for tumorigenesis.
Transgenic mice provide genetic evidence that transforming growth factor alpha promotes skin tumorigenesis via H-ras-dependent and H-ras-independent pathways.
Translation-dependent mechanisms lead to PML upregulation and mediate oncogenic K-RAS induced cellular senescence.
Treatment with lovastatin, cholestyramine or niacin alters K-ras membrane association in mouse lung in a strain-dependent manner: results in females.
Tumor necrosis factor links chronic obstructive pulmonary disease and K-ras mutant lung cancer through induction of an immunosuppressive pro-tumor microenvironment.
Tumorigenesis of K-ras mutation in human endometrial carcinoma via upregulation of estrogen receptor.
Understanding the Complexity of the Tumor Microenvironment in K-ras Mutant Lung Cancer: Finding an Alternative Path to Prevention and Treatment.
Unique K-ras mutational pattern in pancreatic adenocarcinoma from Taiwanese patients.
Up-regulation of vascular endothelial growth factor/vascular permeability factor in mouse skin carcinogenesis correlates with malignant progression state and activated H-ras expression levels.
Upregulation of non-mutated H-ras and its upstream and downstream signaling proteins in colorectal cancer.
Utilization of K-ras mutations identified in stool DNA for the early detection of colorectal cancer.
Variant mutational activation of the K-ras oncogene in renal mesenchymal tumors induced in newborn F344 rats by methyl(methoxymethyl)nitrosamine.
Variation in K-ras codon 12 point mutation rate with histological atypia within individual colorectal tumors.
Villous, hypermucinous mucosa in long standing ulcerative colitis shows high frequency of K-ras mutations.
Viruses, oncogenes, and cancer.
Wild-type K-ras has a tumour suppressor effect on carcinogen-induced murine colorectal adenoma formation.
Wnt/beta-catenin/tcf signaling: a critical pathway in gastrointestinal tumorigenesis.
[Activation of proto-oncogenes induced by MNNG on primary culture of human gastric epithelium and immortalized human gastric epithelial cell line]
[Alteration of the K-ras and p16/CDKN2 gene in endocrine pancreatic carcinomas]
[Carcinogenesis and its mechanism of mutant-type[12Asp]K-ras4B gene]
[CNC proteins in physiology and pathology].
[Colorectal carcinogenesis: a historical review]
[Detection of H-ras and K-ras in tumors of gastrointestinal-pancreatic system]
[Detection of ras gene mutation in various stages of gastric cancer by PCR/RFLP SSCP and DNA sequencing]
[Diagnosis of colorectal cancer from DNA level]
[Diagnostic and oncologic updating on gallbladder papilloma. Personal experience and review of the literature]
[Differential genetic pathway of duct and acinar carcinomas of the pancreas]
[Effect of PCBs on mouse lung tumorigenesis induced by 1-nitropyrene: a preliminary report]
[Effect of shRNA-mediated CDC42 knockdown on morphology of colorectal cancer cells in vitro].
[Expression and mutation of p53 and H-ras genes in the carcinogenesis and development of gastric adenocarcinoma induced by MNNG in rats]
[Expressions of 8-OH-dG, k-ras, and p53 genes in pleural effusion cells and their clinical significances]
[Genetic alterations and transformations in development and establishment of uterine endometrial carcinomas]
[Genetic alterations of human colorectal cancer]
[Genetic investigations for lung carcinoma]
[Identification analysis of eukaryotic expression plasmid Rap2a and its effect on the migration of lung cancer cells].
[Influence of compensatory hepatocyte proliferation on the carcinogenesis of N-nitrosodimethylamine]
[K-ras gene mutation in gallbladder carcinoma]
[K-ras gene mutations in adenomas from familial adenomatous polyposis]
[K-ras mutation analysis in ovarian serous borderline and malignant tumors]
[KRAS and bronchial adenocarcinoma. Between disappointments and hopes].
[Microdissection and PCR-SSCP detected mutation and expression of p53 and K-ras gene in carcinogenesis and development of induced rat lung carcinoma]
[Molecular diagnosis of pancreatic cancer]
[Molecular pathways of pancreatic carcinogenesis]
[Molecular-genetic analysis of clonal intratumoral heterogeneity on colorectal adenocarcinomas]
[Molecular-pathological problems of genetic diagnosis for colorectal cancer]
[Multiple gene alterations involved in the processor of human gastric carcinogenesis]
[New molecular targets in pancreatic cancer]
[Pathogenesis of human cancer]
[Pathophysiology and gene abnormalities of endocrine tumors]
[Prevalence of K-ras gene mutations in human colorectal cancers]
[Pulmonary carcinogenesis susceptibility-associated single-nucleotide polymorphisms in K-ras intron 2 affect the binding of factor Gata-6 but not gene expression]
[Research advances on bladder cancer associated genes]
[Serous genital carcinoma : Molecular pathogenesis and the role of tubal fimbria.]
[Study of 8-OH-dG and its correlation with several cancer related gene in lung cancer tissues]
[The mouse ovarian surface epithelium cells (MOSE) transformation induced by c-myc/K-ras in]
[The RAS paradoxon of the EGFR-targeted therapy of colorectal cancer]
[The roles of H. pylori infection and K-ras gene mutation in gastric carcinogenesis]
Carcinoid Tumor
Analysis of K-ras, N-ras, H-ras, and p53 in lung neuroendocrine neoplasms.
Carcinoid tumors of the extrahepatic bile ducts: a study of seven cases.
Comparison of mutations in the p53 and K-ras genes in lung carcinomas from smoking and nonsmoking women.
Genetic alteration in carcinoid tumors of the lung.
Genetic alterations in goblet cell carcinoids of the vermiform appendix and comparison with gastrointestinal carcinoid tumors.
K-ras and p53 mutations in the pathogenesis of classical and goblet cell carcinoids of the appendix.
Morphological-histochemical study of intestinal carcinoids and K-ras mutation analysis in appendiceal carcinoids.
The presence of K-12 ras mutations in duodenal adenocarcinomas and the absence of ras mutations in other small bowel adenocarcinomas and carcinoid tumors.
Vascular endothelial growth factor and nitric oxide synthase expression in human lung cancer and the relation to p53.
[Detection of H-ras and K-ras in tumors of gastrointestinal-pancreatic system]
[Detection of K-ras oncogene activation in human lung cancer and its possible clinical application]
Carcinoma
"Low-risk" and "high-risk" HPV-infection and K-ras gene point mutations in human cervical cancer: a study of 31 cases.
A case of colorectal carcinoma in adenoma analyzed by a cDNA array.
A cell line from a human ovarian carcinoma with amplification of the K-ras gene.
A clinicopathologic and immunohistochemical study of 35 anaplastic carcinomas of the pancreas with a review of the literature.
A combinatorial approach for selectively inducing programmed cell death in human pancreatic cancer cells.
A comparison of Direct sequencing, Pyrosequencing, High resolution melting analysis, TheraScreen DxS, and the K-ras StripAssay for detecting KRAS mutations in non small cell lung carcinomas.
A detailed analysis of K-ras point mutations in relation to tumor progression and survival in colorectal cancer patients.
A detailed analysis of the role of K-ras gene mutation in the progression of colorectal adenoma.
A disconnect between antitumor and antiangiogenic effects of fluvastatin in vitro and in vivo.
A double germline mutations in the APC and p53 genes.
A dualistic model for endometrial carcinogenesis based on immunohistochemical and molecular genetic analyses.
A farnesyltransferase inhibitor induces tumor regression in transgenic mice harboring multiple oncogenic mutations by mediating alterations in both cell cycle control and apoptosis.
A novel high-specificity approach for colorectal neoplasia: Detection of K-ras2 oncogene mutation in normal mucosa.
A novel radioresistant mechanism of galectin-1 mediated by H-Ras-dependent pathways in cervical cancer cells.
A Phase I trial of H-ras antisense oligonucleotide ISIS 2503 administered as a continuous intravenous infusion in patients with advanced carcinoma.
A possible multiclonal development in human colonic carcinomas.
A prospective study of detection of pancreatic carcinoma by combined plasma K-ras mutations and serum CA19-9 analysis.
A rapid PCR ELISA for the detection of activated K-ras in colorectal cancer.
A recombinantly tailored ?-defensin that displays intensive macropinocytosis-mediated uptake exerting potent efficacy against K-Ras mutant pancreatic cancer.
A relationship between K-ras gene mutations and some clinical and histologic variables in patients with primary colorectal carcinoma.
A synthetic lethal interaction between K-Ras oncogenes and Cdk4 unveils a therapeutic strategy for non-small cell lung carcinoma.
A universal method for the mutational analysis of K-ras and p53 gene in non-small-cell lung cancer using formalin-fixed paraffin-embedded tissue.
A very large villous adenoma with an adjacent cancer of the rectum: an informative case for testing the proposed molecular basis of colorectal tumorigenesis.
Absence of H-ras point mutation at codon 12 in N-methyl-N-nitrosourea-induced hepatocellular neoplasms in the rat.
Absence of point mutation in codons 12 and 13 of K-RAS oncogene in HPV-associated high grade dysplasia and squamous cell cervical carcinoma.
Absence of ras oncogene activation in rat urinary bladder carcinomas induced by N-methyl-N-nitrosourea or N-butyl-N-(4-hydroxybutyl)nitrosamine.
ACB-PCR quantification of K-RAS codon 12 GAT and GTT mutant fraction in colon tumor and non-tumor tissue.
Activated H-ras gene mutations in transitional cell carcinoma of urinary bladder in a Kashmiri population.
Activated H-ras oncogenes in human kidney tumors.
Activated H-ras transforms rat intestinal epithelial cells with expression of alpha-TGF.
Activated K-ras is involved in regulation of integrin expression in human colon carcinoma cells.
Activated Rac1 selectively up-regulates the expression of integrin alpha6beta4 and induces cell adhesion and membrane ruffles of nonadherent colon cancer Colo201 cells.
Activated Vav2 modulates cellular invasion through Rac1 and Cdc42 in oral squamous cell carcinoma.
Activation of c-myc and c-K-ras oncogenes in primary rat tumors induced by ionizing radiation.
Activation of H-Ras and Rac1 correlates with epidermal growth factor-induced invasion in Hs578T and MDA-MB-231 breast carcinoma cells.
Activation of H-ras oncogene in rat bladder tumors induced by N-butyl-N-(4-hydroxybutyl)nitrosamine.
Activation of H-ras oncogenes in preneoplastic mouse mammary tissues.
Activation of K-ras in transplantable pancreatic ductal adenocarcinomas of Syrian golden hamsters.
Activation of RAS family genes in urothelial carcinoma.
Activation of the mTOR signaling pathway in renal clear cell carcinoma.
Activation of the ras genes in malignant and premalignant colorectal tumors.
Acute sensitivity of the oral mucosa to oncogenic K-ras.
Additional characterization of a hexanucleotide polymorphic site in the first intron of human H-ras gene: comparative study of its alterations in non-small cell lung carcinomas and sporadic invasive breast carcinomas.
Adenocarcinoma arising in gastric heterotopic pancreas: clinicopathological and immunohistochemical study with genetic analysis of a case.
Age-associated inflammation connects RAS-induced senescence to stem cell dysfunction and epidermal malignancy.
Allele-specific detection of K-ras oncogene expression in human non-small-cell lung carcinomas.
Allelotype analysis of gallbladder carcinoma associated with anomalous junction of pancreaticobiliary duct.
Allelotype analysis of mouse lung carcinomas reveals frequent allelic losses on chromosome 4 and an association between allelic imbalances on chromosome 6 and K-ras activation.
Allelotype of human thyroid tumors: loss of chromosome 11q13 sequences in follicular neoplasms.
Alteration of the p53 tumor suppressor gene occurs independently of K-ras activation and more frequently in serous adenocarcinomas than in other common epithelial tumors of the human ovary.
Alterations of p16/CDKN2, p53 and ras genes in oral squamous cell carcinomas and premalignant lesions.
Alterations of p53, cyclin D1, Rb, and H-ras in human oral carcinomas related to tobacco use.
Alterations of tumor suppressor genes and the H-ras oncogene in oral squamous cell carcinoma.
Amplification of wild-type K-ras promotes growth of head and neck squamous cell carcinoma.
Amplified expression of p21 ras protein in hormone-dependent mammary carcinomas of humans and rodents.
An anti-K-ras ribozyme suppresses oncogene expression and cell growth of human pancreatic cancer.
An association study on genetic polymorphisms of Rab37 gene with the risk of esophageal squamous cell carcinoma in a Chinese Han population.
An effect of K-ras gene mutation on epidermal growth factor receptor signal transduction in PANC-1 pancreatic carcinoma cells.
An immortalization-dependent switch in integrin function up-regulates MMP-9 to enhance tumor cell invasion.
Analysis of K-ras codon 12 and TP53 mutations in patients with advanced colorectal carcinoma.
Analysis of K-ras codon 12 point mutations using duodenal lavage fluid for diagnosis of pancreatic carcinoma.
Analysis of K-ras gene mutations in lung carcinomas: correlation with gender, histological subtypes, and clinical outcome.
Analysis of K-ras gene mutations in malignant and nonmalignant endobronchial tissue obtained by fiberoptic bronchoscopy.
Analysis of K-ras mutations in pancreatic tissue after fine needle aspirates.
Analysis of K-ras oncogene mutation directly applied to atypical cell clusters on cytologic smear slides of bile and pancreatic juice.
Analysis of K-ras, N-ras, H-ras, and p53 in lung neuroendocrine neoplasms.
Analysis of K-ras, p53 and c-raf-1 mutations in beryllium-induced rat lung tumors.
Analysis of p53 tumor suppressor gene, H-ras protooncogene and proliferating cell nuclear antigen (PCNA) in squamous cell carcinomas of HRA/Skh mice following exposure to 8-methoxypsoralen (8-MOP) and UVA radiation (PUVA therapy).
Analysis of ras gene mutations in biliary and pancreatic tumors by polymerase chain reaction and direct sequencing.
Analysis of the anatomic subsites, gender and age in unresectable advanced colorectal carcinomas in Tochigi, Japan suggests a shift in location towards the right side colon in elderly patients treated with cetuximab.
Analysis of the genetic alterations in a case of juvenile multiple colon carcinoma with hypogammaglobulinemia.
Analysis of the K-ras and p53 pathways in X-ray-induced lung tumors in the rat.
Analysis of the K-ras/B-raf/Erk signal cascade, p53 and CMAP as markers for tumor progression in colorectal cancer patients.
Animal models for the study of prostate carcinogenesis.
Animal products and K-ras codon 12 and 13 mutations in colon carcinomas.
Antisera to the variable region of ras oncogene proteins, and specific detection of H-ras expression in an experimental model of chemical carcinogenesis.
APC and K-ras gene mutation in aberrant crypt foci of human colon.
APC, K-ras codon 12 mutations and p53 gene expression in carcinoma and adenoma of the gall-bladder suggest two genetic pathways in gall-bladder carcinogenesis.
Aphanin, a triterpenoid from Amoora rohituka inhibits K-Ras mutant activity and STAT3 in pancreatic carcinoma cells.
Apoptosis of Human Pancreatic Carcinoma PC-2 Cells by an Antisense Oligonucleotide Specific to Point Mutated K-ras.
Appendiceal mucinous cystadenocarcinoma with mural nodules of anaplastic carcinoma and K-RAS mutation.
Application of pyrosequencing technique for improved detection of K-Ras mutation in formalin-fixed and paraffin-embedded prostate carcinoma tissues in Chinese patients.
Application of the p53 and K-ras gene mutation patterns for cytologic diagnosis of recurrent lung carcinomas.
Assay design and optimization of mutant-enriched PCR based method for detection of K-ras gene mutations in pancreatic carcinoma.
Assembling Mn:ZnSe quantum dots-siRNA nanoplexes for gene silencing in tumor cells.
Association of K-ras mutations with liver metastases from colorectal carcinoma.
Association of matrilysin mRNA expression with K-ras mutations and progression in pancreatic ductal adenocarcinomas.
Author Correction: Rap2a serves as a potential prognostic indicator of renal cell carcinoma and promotes its migration and invasion through up-regulating p-Akt.
Autoimmune pancreatitis and biliary intraepithelial neoplasia of the common bile duct: A case with diagnostically challenging but pathogenetically significant association.
Beta 1-6 branching of N-linked carbohydrate is associated with K-ras mutation in human colon carcinoma cell lines.
beta-catenin mutations are absent in hepatocellular carcinomas of SV40 T-antigen transgenic mice.
Biliopancreatic malignancy: screening the at risk patient with molecular markers.
Biodegradable Nanocapsules as siRNA Carriers for Mutant K-Ras Gene Silencing of Human Pancreatic Carcinoma Cells.
Black tea extract can modulate protein expression of H-ras, c-Myc, p53, and Bcl-2 genes during pulmonary hyperplasia, dysplasia, and carcinoma in situ.
Blocking oncogenic Ras signaling for cancer therapy.
Bmi-1 Cooperates with H-Ras to Transform Human Mammary Epithelial Cells via Dysregulation of Multiple Growth-Regulatory Pathways.
Both farnesyltransferase and geranylgeranyltransferase I inhibitors are required for inhibition of oncogenic K-Ras prenylation but each alone is sufficient to suppress human tumor growth in nude mouse xenografts.
BRAF and FBXW7 (CDC4, FBW7, AGO, SEL10) mutations in distinct subsets of pancreatic cancer: potential therapeutic targets.
Bronchioloalveolar adenocarcinoma of lung: monoclonal origin for multifocal disease.
Bronchioloalveolar lung carcinomas: K-ras mutations are constant events in the mucinous subtype.
c-Ki-ras point mutations in ductectatic-type mucinous cystic neoplasms of the pancreas.
c-Raf, but not B-Raf, is essential for development of K-Ras oncogene-driven non-small cell lung carcinoma.
Can Different Thyroid Tumor Types Be Distinguished by Polymerase Chain Reaction-Based K-ras Mutation Detection?
Can K-ras codon 12 mutations be used to distinguish benign bile duct proliferations from metastases in the liver? A molecular analysis of 101 liver lesions from 93 patients.
Cannabinoid receptor type 1 (CB1) activation inhibits small GTPase RhoA activity and regulates motility of prostate carcinoma cells.
Carcinogen exposure, p53 alteration, and K-ras mutation in synchronous multiple primary lung carcinoma.
Carcinogenesis in the biliary system associated with APDJ.
Carcinogenesis of malignant lesions of the gall bladder. The impact of chronic inflammation and gallstones.
Carcinogenic role of K-Ras-ERK1/2 signaling in bladder cancer via inhibition of H1.2 phosphorylation at T146.
Carcinoma of the colon in childhood; report of 2 cases expressing p53 without K-ras mutation.
CCL19-induced chemokine receptor 7 activates the phosphoinositide-3 kinase-mediated invasive pathway through Cdc42 in metastatic squamous cell carcinoma of the head and neck.
CCR7 regulates cell migration and invasion through MAPKs in metastatic squamous cell carcinoma of head and neck.
CD44 expression in colorectal adenomas is an early event occurring prior to K-ras and p53 gene mutation.
Cdc42 is involved in basal cell carcinoma carcinogenesis.
Cdc42 is required for EGF-stimulated protrusion and motility in MTLn3 carcinoma cells.
CDC42-positive macrophages may prevent malignant transformation of ovarian endometriosis.
CEA is the major PHA-L-reactive glycoprotein in colon carcinoma cell lines and tumors: relationship between K-ras activation and beta1-6 branching of N-linked carbohydrate on CEA.
Cellular phenotypes of differentiated-type adenocarcinomas and precancerous lesions of the stomach are dependent on the genetic pathways.
Characterisation of immune responses in pancreatic carcinoma patients after mutant p21 ras peptide vaccination.
Characteristics in primary signet-ring cell carcinoma of the colorectum, from clinicopathological observations.
Characterization of a novel oncogenic K-ras mutation in colon cancer.
Characterization of adenocarcinoma of the lung in a familial adenomatous polyposis patient.
Characterization of lectin resistant cell populations derived from human colon carcinoma: correlation of K-Ras with beta1-6 branching of N-linked carbohydrate and CEA production.
Characterization of Rab27a and JFC1 as constituents of the secretory machinery of prostate-specific antigen in prostate carcinoma cells.
Chromosomal alterations in lung adenocarcinoma from smokers and nonsmokers.
Cigarette smoking and genetic alterations in sporadic colon carcinomas.
Circulating miR-16-5p, miR-92a-3p, and miR-451a in Plasma from Lung Cancer Patients: Potential Application in Early Detection and a Regulatory Role in Tumorigenesis Pathways.
Clear cell carcinoma of the pancreas: an adenocarcinoma with ductal phenotype.
Clinical application of K-ras oncogene mutations in pancreatic carcinoma: detection of micrometastases.
Clinical implications of K-ras mutations in malignant epithelial tumors of the endometrium.
Clinical value of K-ras codon 12 analysis and endobiliary brush cytology for the diagnosis of malignant extrahepatic bile duct stenosis.
Clinicopathologic analysis of k-ras, p53, and ERBB-2 gene alterations in pulmonary adenocarcinoma.
Clinicopathologic features and genetic alterations in endometrioid carcinoma of the uterus with villoglandular differentiation.
Clinicopathological and genetic characteristics of mucinous carcinomas in the colorectum.
Clinicopathological observations of colorectal serrated lesions associated with invasive carcinoma and high-grade intraepithelial neoplasm.
Clinicopathological pattern and Annexin A2 and Cdc42 status in patients presenting with differentiation and lymphnode metastasis of esophageal squamous cell carcinomas.
Cloning and sequencing of CATR1.3, a human gene associated with tumorigenic conversion.
Colon carcinoma K-ras 2 oncogene of a familial polyposis coli patient.
Combination analysis of genetic alterations and cell proliferation in small intestinal carcinomas.
Combined small-cell carcinoma of the stomach: p53 and K-ras gene mutational analysis supports a monoclonal origin of three histological components.
Comparative analysis of K-ras point mutation, telomerase activity, and p53 overexpression in pancreatic tumours.
Comparative molecular pathology of sporadic hyperplastic polyps and neoplastic lesions from the same individual.
Comparison of K-ras oncogene activation in pancreatic duct carcinomas and cholangiocarcinomas induced in hamsters by N-nitrosobis(2-hydroxypropyl)amine.
Comparison of mutations in the p53 and K-ras genes in lung carcinomas from smoking and nonsmoking women.
Comparison of ras activation in prostate carcinoma in Japanese and American men.
Comprehensive Mutation Analysis of PIK3CA, p14ARF, p16INK4a and p21Waf1/Cip1 Genes is Suggestive of a Non- Neoplastic Nature of Phenytoin Induced Gingival Overgrowth.
Conditional expression of mutated K-ras accelerates intestinal tumorigenesis in Msh2-deficient mice.
Cooperative induction of rat mammary cancer by radiation and 1-methyl-1-nitrosourea via the oncogenic pathways involving c-Myc activation and H-ras mutation.
Correlation between K-ras gene mutation and prognosis of patients with nonsmall cell lung carcinoma.
Correlation of genes associated with drug response to prognosis of large cell lung carcinoma.
Correlation of immunohistochemical staining p63 and TTF-1 with EGFR and K-ras mutational spectrum and diagnostic reproducibility in non small cell lung carcinoma.
CpG island promoter hypermethylation of the Ras-effector gene NORE1A occurs in the context of a wild-type K-ras in lung cancer.
Crosstalk between Pten and Ras signaling pathways in tumor development.
Cyclin D1 and p21 in ulcerative colitis-related inflammation and epithelial neoplasia: a study of aberrant expression and underlying mechanisms.
Cyclooxygenase 2 expression and molecular alterations in Peutz-Jeghers hamartomas and carcinomas.
Cyclooxygenase-2 overexpression is related to polypoid growth and K-ras gene mutation in T1 colorectal carcinomas.
Deletion of epidermal Rac1 inhibits HPV-8 induced skin papilloma formation and facilitates HPV-8- and UV-light induced skin carcinogenesis.
Deletion of Lactate Dehydrogenase-A in Myeloid Cells Triggers Antitumor Immunity.
Deregulated matriptase causes ras-independent multistage carcinogenesis and promotes ras-mediated malignant transformation.
Deregulation of SLIT2-Mediated Cdc42 Activity Is Associated with Esophageal Cancer Metastasis and Poor Prognosis.
Deregulation of the cyclin D1/Cdk4 retinoblastoma pathway in rat mammary gland carcinomas induced by the food-derived carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.
Detection and clinical correlations of ras gene mutations in human ovarian tumors.
Detection of activated K-ras in non-small cell lung cancer by membrane array: a comparison with direct sequencing.
Detection of activating mutations in the ras family genes in cytological specimens from lung-tumors.
Detection of colorectal cancer K-ras mutations using a simplified oligonucleotide ligation assay.
Detection of H-ras gene point mutations in transitional cell carcinoma of human urinary bladder using polymerase chain reaction.
Detection of HPV and ras gene mutations in cervical smears from female genital lesions.
Detection of human papilloma virus (HPV) and K-ras mutations in human lung carcinomas.
Detection of K-ras gene mutation at codon 12 by pancreatic duct brushing for pancreatic cancer.
Detection of K-ras gene mutations at codon 12 in the pancreatic juice of patients with intraductal papillary mucinous tumors of the pancreas.
Detection of K-ras mutation in sputum by mutant-allele-specific amplification (MASA).
Detection of K-ras mutations in lung carcinomas: relationship to prognosis.
Detection of K-ras mutations in mucinous pancreatic duct hyperplasia from a patient with a family history of pancreatic carcinoma.
Detection of K-ras mutations in stools of patients with colorectal cancer by mutant-enriched PCR.
Detection of K-ras mutations in the stool of patients with pancreatic adenocarcinoma and pancreatic ductal hyperplasia.
Detection of K-ras oncogene mutations in bronchoalveolar lavage fluid for lung cancer diagnosis.
Detection of K-ras point mutations in the supernatants of peritoneal and pleural effusions for diagnosis complementary to cytologic examination.
Detection of low-fraction K-ras mutations in primary lung tumors using a sensitive method.
Detection of mutated K12-ras in histologically negative lymph nodes as an indicator of poor prognosis in stage II colorectal cancer.
Detection of pancreatic carcinoma: diagnostic value of K-ras mutations in circulating DNA from serum.
Detection of point mutation in K-ras oncogene at codon 12 in pancreatic diseases.
Detection of point mutations in K-ras gene at codon 12 in bile from percutaneous transhepatic choledochal drainage tubes for diagnosis of biliary strictures.
Detection of point mutations in the K-ras oncogene at codon 12 in pure pancreatic juice for diagnosis of pancreatic carcinoma.
Detection of rare circulating human colon tumor cells in a nude mouse xenograft model.
Detection of ras gene mutations in human lung cancer: comparison of two screening assays based on the polymerase chain reaction.
Detection of ras gene mutations in peripheral blood of carcinoma patients using CD45 immunomagnetic separation and nested mutant allele specific amplification.
Detection of the H-RAS oncogene in human thyroid anaplastic carcinomas.
Determination of pancreatic ductal carcinoma histogenesis by analysis of mucous quality and K-ras mutation.
Diagnosis of pancreatic lesions using fine needle aspiration cytology: detection of K-ras point mutations using solid phase minisequencing.
Diagnostic accuracy of K-ras mutation for pancreatic carcinoma: a meta-analysis.
Diagnostic and prognostic value of incidence of K-ras codon 12 mutations in resected distal bile duct carcinoma.
Diagnostic utility of K-ras mutations in fine-needle aspirates of pancreatic masses.
Diagnostic value of combining CA 19-9 and K-ras gene mutation in pancreatic carcinoma: a meta-analysis.
Differences in mucus and K-ras mutation in relation to phenotypes of tumors of the papilla of vater.
Different amounts of K-ras mutant epithelial cells in pancreatic carcinoma and mass-forming pancreatitis.
Different types of K-Ras mutations are conversely associated with overall survival in patients with colorectal cancer.
Differential contribution of the ERK and JNK mitogen-activated protein kinase cascades to Ras transformation of HT1080 fibrosarcoma and DLD-1 colon carcinoma cells.
Differential expression of c-myc and H-ras oncogenes in Barrett's epithelium. A study using colorimetric in situ hybridization.
Differential expression of cell cycle regulators in phenotypic variants of transgenically induced bladder tumors: implications for tumor behavior.
Differential expression of miR-195 in esophageal squamous cell carcinoma and miR-195 expression inhibits tumor cell proliferation and invasion by targeting of Cdc42.
Disseminated colorectal tumor cells in organs prone to metastasis detected by new double enriched nested-PCR in comparison with recognized assays.
Distribution of p53 and K-ras mutations in human lung cancer tissues.
Diverse tumorigenic pathways in ovarian serous carcinoma.
DNA aneuploidy in morphologically normal colons from patients with colon cancer.
DNA content and other factors associated with ten-year survival after resection of pancreatic carcinoma.
DNA hypermethylation status of multiple genes in prostate adenocarcinomas.
Does Harvey-Ras gene expression lead to oral squamous cell carcinoma? A clinicopathological aspect.
Down-regulation of the Rho GTPase signaling pathway is involved in the microRNA-138 mediated inhibition of cell migration and invasion in tongue squamous cell carcinoma.
Downregulation of survivin and aurora a by histone deacetylase and RAS inhibitors: A new drug combination for cancer therapy.
Dysregulation of Rab37-Mediated Cross-talk between Cancer Cells and Endothelial Cells via Thrombospondin-1 Promotes Tumor Neovasculature and Metastasis.
Early detection of pancreatic cancer in patients with chronic pancreatitis: diagnostic utility of a K-ras point mutation in the pancreatic juice.
Effect of increased expression of both ras-related C3 botulinum toxin substrate 1 and p21-activated kinase 1 in patients with N0M0 upper urinary tract urothelial carcinoma and cancer-free surgical margins.
Effect of novel CAAX peptidomimetic farnesyltransferase inhibitor on angiogenesis in vitro and in vivo.
Effect of polyamine oxidase inhibition on the colonic malignant transformation process induced by 1,2-dimethylhydrazine.
Effect of Rab23 on the proliferation and apoptosis in breast cancer.
EGFr and c-erB2mRNA expression in urinary bladder superficial carcinomas.
EGFR and K-ras gene mutation status in squamous cell anal carcinoma: a role for concurrent radiation and EGFR inhibitors?
Emerging prognostic markers related to mesenchymal characteristics of poorly differentiated breast cancers.
EML4-ALK fusion transcripts, but no NPM-, TPM3-, CLTC-, ATIC-, or TFG-ALK fusion transcripts, in non-small cell lung carcinomas.
Endometrial carcinomas with significant mucinous differentiation associated with higher frequency of k-ras mutations: a morphologic and molecular correlation study.
Epidermal growth factor receptor and K-Ras mutations and resistance of lung cancer to insulin-like growth factor 1 receptor tyrosine kinase inhibitors.
Epidermal growth factor receptor and K-RAS status in two cohorts of squamous cell carcinomas.
Epigenetic inactivation of the Ras-association domain family 1 (RASSF1A) gene and its function in human carcinogenesis.
ERBB2 kinase domain mutation in a gastric cancer metastasis.
ERBB2 kinase domain mutation in the lung squamous cell carcinoma.
ERK2-dependent reactivation of Akt mediates the limited response of tumor cells with constitutive K-RAS activity to PI3K inhibition.
Establishment and molecular profiling of a novel human pancreatic cancer panel for 5-FU.
Estimation of risk based on multiple events in radiation carcinogenesis of rat skin.
Evidence for aldosterone-dependent growth of renal cell carcinoma.
Expression and alteration of ras and p53 proteins in patients with lung carcinoma accompanied by idiopathic pulmonary fibrosis.
Expression and mutation analysis of epidermal growth factor receptor in head and neck squamous cell carcinoma.
Expression of CDC42 in cervical squamous cell carcinoma and its correlation with clinicopathologic characteristics.
Expression of epidermal growth factor receptor, but not K-RAS mutations, is present in congenital cystic airway malformation/congenital pulmonary airway malformation.
Expression of intermediate filament proteins by normal and transformed mouse epidermal-keratinocytes in culture.
Expression of Ki-67, p53, and K-ras in chronic pancreatitis and pancreatic ductal adenocarcinoma.
Expression of Kirsten-ras p21 in gastric cancer correlates with tumor progression and is prognostic.
Expression of P21-activated kinase 1 and cell division control protein 42 homolog correlates with clinicopathological features and prognosis in cervical carcinoma.
Expression of p21ras-related protein in the plasma and tissue of patients with adenomas and carcinomas of the colon.
Expression of Rac1, HIF-1?, and VEGF in Gastric Carcinoma: Correlation with Angiogenesis and Prognosis.
Expression of seven main Rho family members in gastric carcinoma.
Expression of simple epithelial cytokeratins in mouse epidermal keratinocytes harboring Harvey ras gene alterations.
Expression of the farnesyltransferase beta-subunit gene in human ovarian carcinoma: correlation to K-ras mutation.
Expression profile of Rho kinases in urinary bladder cancer.
Fibroblast-led collective invasion of carcinoma cells with differing roles for RhoGTPases in leading and following cells.
Filamin C promotes lymphatic invasion and lymphatic metastasis and increases cell motility by regulating Rho GTPase in esophageal squamous cell carcinoma.
Follow-Up Study of K-ras Mutations in the Plasma of Patients With Pancreatic Cancer: Correlation With Clinical Features and Carbohydrate Antigen 19-9.
Frequency of H-ras mutations in human bladder cancer detected by direct sequencing.
Frequent hypermethylation of RASSF1A in early flat-type colorectal tumors.
Frequent K-ras mutations and absence of p53 mutations in mucin-producing tumors of the pancreas.
Frequent mutations of the p53 gene and infrequent H- and K-ras mutations in urinary bladder carcinomas of NON/Shi mice treated with N-butyl-N-(4-hydroxybutyl)nitrosamine.
Frequent p53 and H-ras mutations in benzene- and ethylene oxide-induced mammary gland carcinomas from B6C3F1 mice.
Frequent p53 mutation in brain (fetal)-type glycogen phosphorylase positive foci adjacent to human 'de novo' colorectal carcinomas.
Frequent polymorphic variations but rare tumour specific mutations of the S100A2 on 1q21 in non-small cell lung cancer.
Frequent RASSF1A promoter hypermethylation and K-ras mutations in pancreatic carcinoma.
From pancreatic intraepithelial neoplasia to cancer: a dramatic progression with K-ras status analysis.
Gain-of-function mutant p53 but not p53 deletion promotes head and neck cancer progression in response to oncogenic K-ras.
Gallbladder adenomas have molecular abnormalities different from those present in gallbladder carcinomas.
Gallbladder carcinoma.
Gene analysis of K-, H-ras, p53, and retinoblastoma susceptibility genes in human lung cancer cell lines by the polymerase chain reaction/single-strand conformation polymorphism method.
Gene expression and protein array studies of folliculin-regulated pathways.
Gene expression studies demonstrate that the K-ras/Erk MAP kinase signal transduction pathway and other novel pathways contribute to the pathogenesis of cumene-induced lung tumors.
Gene mutations of K-ras in gallbladder mucosae and gallbladder carcinoma with an anomalous junction of the pancreaticobiliary duct.
Generation of monoclonal antibodies specific for ras p21 Glu-12 oncoproteins: detection in carcinogen-induced mammary carcinomas.
Generation of stable CD4+ and CD8+ T cell lines from patients immunized with ras oncogene-derived peptides reflecting codon 12 mutations.
Genetic aberrations of the K-ras proto-oncogene in bladder cancer in Kashmiri population.
Genetic abnormalities involved in the pathogenesis of gallbladder carcinoma.
Genetic alteration in carcinoid tumors of the lung.
Genetic alterations in gallbladder carcinoma.
Genetic alterations in K-ras and p53 cancer genes in lung neoplasms from B6C3F1 mice exposed to cumene.
Genetic alterations in ovarian carcinoma: with specific reference to histological subtypes.
Genetic alterations in p53 and k-ras in lung-cancer in relation to histopathology of the tumor and smoking history of the patient.
Genetic alterations in the 61st codon of the H-ras oncogene isolated from archival sections of hepatic hyperplasias, adenomas and carcinomas in control groups of B6C3F1 mouse bioassay studies conducted from 1979 to 1986.
Genetic Alterations of K-ras, p53, c-erbB-2, and DPC4 in Pancreatic Ductal Adenocarcinoma and Their Correlation With Patient Survival.
Genetic alterations of mixed hyperplastic adenomatous polyps in the colon and rectum.
Genetic analysis of DNA excreted in urine: a new approach for detecting specific genomic DNA sequences from cells dying in an organism.
Genetic changes and histopathological types in colorectal tumors from patients with familial adenomatous polyposis.
Genetic changes in skin tumor progression: correlation between presence of a mutant ras gene and loss of heterozygosity on mouse chromosome 7.
Genetic changes of p53, K-ras, and microsatellite instability in gallbladder carcinoma in high-incidence areas of Japan and Hungary.
Genetic factors in ovarian carcinoma.
Genetic instability and p53 mutations in metastatic foci of mouse urinary bladder carcinomas induced by N-butyl-N-(4-hydroxybutyl)nitrosamine.
Genetic instability in renal cell carcinoma.
Genetic mutations of p53 and k-ras in gastric carcinoma patients from Hunan, China.
Genetic pathways of 'de novo' colorectal carcinomas with reference to fetal-type glycogen phosphorylase positive foci.
Genetic profile of 22 pancreatic carcinoma cell lines. Analysis of K-ras, p53, p16 and DPC4/Smad4.
Glutathione S-transferase mu1 null genotype is associated with K-ras gene mutation in lung adenocarcinoma among smokers.
Glutathione S-transferase-pi overexpression is closely associated with K-ras mutation during human colon carcinogenesis.
Growth factor-dependent activation of the Ras-Raf-MEK-MAPK pathway in the human pancreatic carcinoma cell line PANC-1 carrying activated K-ras: implications for cell proliferation and cell migration.
Growth inhibition of non-small-cell lung carcinoma by BN/GRP antagonist is linked with suppression of K-Ras, COX-2, and pAkt.
GSTM1, P53 and K-ras molecular detection in resectable non-small cell lung cancer by denaturing gradient gel electrophoresis-bronchoalveolar lavage fluid analysis.
H-ras 61st codon activation in archival proliferative hepatic lesions isolated from female B6C3F1 mice exposed to the leukotriene D4-antagonist, LY171883.
H-Ras activation and fibroblast-induced TGF-? signaling promote laminin-332 accumulation and invasion in cutaneous squamous cell carcinoma.
H-ras and c-fos exhibit similar expression patterns during most stages of oral oncogenesis.
H-ras and Nm23-H1 gene expression and proteolytic activity in squamous cell carcinoma of the uterine cervix.
H-ras codon 12 mutation in cervical dysplasia.
H-ras gene amplification or mutation is not common in human primary breast cancer.
H-ras mutation is an additional event of sarcomatous transformation in aerodigestive spindle cell carcinoma.
H-Ras mutation modulates the expression of major cell cycle regulatory proteins and disease prognosis in oral carcinoma.
H-ras mutations in human pituitary carcinoma metastases.
H-ras mutations in rat urinary bladder carcinomas induced by N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide and sodium saccharin, sodium ascorbate, or related salts.
H-Ras oncogene counteracts the growth-inhibitory effect of genistein in T24 bladder carcinoma cells.
H-ras oncogene mutation and human papillomavirus infection in oral carcinomas.
H-ras oncogene mutations during development of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced rat mammary gland cancer.
H-ras protooncogene mutations in human thyroid neoplasms.
H-RAS V12-induced radioresistance in HCT116 colon carcinoma cells is heregulin dependent.
H-ras-1 gene mutations in basal cell carcinoma: automated direct sequencing of clinical specimens.
Hammerhead ribozyme specifically inhibits mutant K-ras mRNA of human pancreatic cancer cells.
Harvey ras (H-ras) point mutations are induced by 4-nitroquinoline-1-oxide in murine oral squamous epithelia, while squamous cell carcinomas and loss of heterozygosity occur without additional exposure.
Helicobacter pylori induces formation of stress fibers and membrane ruffles in AGS cells by rac activation.
Heparanase cooperates with Ras to drive breast and skin tumorigenesis.
Heterogeneous distribution of K-ras mutations in primary colon carcinomas: implications for EGFR-directed therapy.
Heterogeneous distribution of K-ras-mutated epithelia in mucinous ovarian tumors with special reference to histopathology.
Heterogeneous immunoreactivity of frozen human benign and malignant breast lesions to C-MYC and C-Ha-ras cellular oncogenes.
HIF-1alpha mRNA and protein upregulation involves Rho GTPase expression during hypoxia in renal cell carcinoma.
High Expression of Cell Division Cycle 42 Promotes Pancreatic Cancer Growth and Predicts Poor Outcome of Pancreatic Cancer Patients.
High expression of RAB27A and TP53 in pancreatic cancer predicts poor survival.
High frequency mutation in codons 12 and 61 of H-ras oncogene in chewing tobacco-related human oral carcinoma in India.
High frequency of K-ras mutations in biliary duct carcinomas of cases with a long common channel in the papilla of Vater.
High frequency of ras mutations in forestomach and lung tumors of B6C3F1 mice exposed to 1-amino-2,4-dibromoanthraquinone for 2 years.
High incidence of H-ras oncogene mutations in squamous cell carcinoma of lip vermilion.
High incidence of point mutation in K-ras codon 12 in carcinoma of the fallopian tube.
High relative biologic effectiveness of carbon ion radiation on induction of rat mammary carcinoma and its lack of H-ras and Tp53 mutations.
High susceptibility of human c-Ha-ras proto-oncogene transgenic rats to carcinogenesis: a cancer-prone animal model.
High TUBB3 expression, an independent prognostic marker in patients with early non small cell lung cancer (NSCLC) treated by preoperative chemotherapy, is regulated by K-Ras signaling pathway.
High-level microsatellite instability is not involved in gallbladder carcinogenesis.
Higher expression of K-ras is associated with parathyroid hormone-related protein-induced hypercalcaemia in renal cell carcinoma.
Histological and genetic changes in malignant transformation of gallbladder adenoma.
Histone deacetylase 1 represses the small GTPase RhoB expression in human nonsmall lung carcinoma cell line.
HLA molecules in basal cell carcinoma of the skin.
Human papillomavirus and mutated H-ras oncogene in cervical carcinomas and pathological negative pelvic lymph nodes: a retrospective follow-up.
Hypermethylation of the Ras association domain family 1A (RASSF1A) gene in gallbladder cancer.
Hypoxia in models of lung cancer: implications for targeted therapeutics.
Hypoxia stimulates carcinoma invasion by stabilizing microtubules and promoting the Rab11 trafficking of the alpha6beta4 integrin.
Hypoxia up-regulates hypoxia-inducible factor-1alpha expression through RhoA activation in trophoblast cells.
Identification of a human CD8+ T lymphocyte neo-epitope created by a ras codon 12 mutation which is restricted by the HLA-A2 allele.
Identification of RAB2A and PRDX1 as the potential biomarkers for oral squamous cell carcinoma using mass spectrometry-based comparative proteomic approach.
Identification of site-specific prognostic biomarkers in patients with oral squamous cell carcinoma.
Immunobead-PCR: a technique for the detection of circulating tumor cells using immunomagnetic beads and the polymerase chain reaction.
Immunohistochemical and genetic analysis of non-small cell and small cell gallbladder carcinoma and their precursor lesions.
Immunohistochemical detection of the H-ras, K-ras, and N-ras oncogenes in squamous cell carcinoma of the head and neck.
Immunohistochemical evaluation of K-ras, p53, and HER-2/neu expression in hyperplastic, dysplastic, and carcinomatous lesions of the pancreas: evidence for multistep carcinogenesis.
Impact of K-Ras Over-expression in Laryngeal Squamous Cell Carcinoma.
Impairing squamous differentiation by Klf4 deletion is sufficient to initiate tongue carcinoma development upon K-Ras activation in mice.
In-silico identification of small molecules targeting H-Ras and in-vitro cytotoxicity with caspase-mediated apoptosis in carcinoma cells.
Increased incidence of squamous cell carcinomas in Mastomys natalensis papillomavirus E6 transgenic mice during two-stage skin carcinogenesis.
Increased susceptibility of H-Ras(G12V)-transformed human urothelial cells to the genotoxic effects of sodium arsenite.
Induction of invasive mouse skin carcinomas in transgenic mice with mutations in both H-ras and p53.
Induction of invasive squamous cell carcinomas in the forestomach of (C3H x MSM)F1, MSM, and C3H mice by N-methyl-N-nitrosourea and mutational analysis of the H-ras and p53 genes.
Induction of reactive oxygen species renders mutant and wild-type K-ras pancreatic carcinoma cells susceptible to Ad.mda-7-induced apoptosis.
Influence of single nucleotide polymorphisms in H-Ras and cyclin D1 genes on oral cancer susceptibility.
Inhibitary effects of antisense oligonucleotide specific to K-ras point mutation on the target gene expression in human pancreatic carcinoma cells.
Inhibition of apoptosis after thymineless stress is conferred by oncogenic K-Ras in colon carcinoma cells.
Inhibition of Calcineurin/NFAT Signaling Blocks Oncogenic H-Ras Induced Autophagy in Primary Human Keratinocytes.
Inhibition of CDC42 reduces macrophage recruitment and suppresses lung tumorigenesis in vivo.
Inhibition of Fos- and Ras-induced transformation by mutant Fos proteins with structural alterations in functionally different domains.
Inhibition of the prenylation of K-Ras, but not H- or N-Ras, is highly resistant to CAAX peptidomimetics and requires both a farnesyltransferase and a geranylgeranyltransferase I inhibitor in human tumor cell lines.
Inhibition of tumor cell growth by monoterpenes in vitro: evidence of a Ras-independent mechanism of action.
Inhibitory effect of sarcophytol A on pancreatic carcinogenesis after initiation by N-nitrosobis(2-oxypropyl)amine in Syrian hamsters.
Integration of multiple signaling pathway activities resolves K-RAS/N-RAS mutation paradox in colon epithelial cell response to inflammatory cytokine stimulation.
Interleukin-10-deficient mice and inflammatory bowel disease associated cancer development.
Interrelationship between the expression of h-ras p21, C-myc and p53 proteins, and the infection of high-risk human papillomaviruses in Japanese patients with esophageal squamous-cell carcinoma.
Intraductal papillary-mucinous tumours represent a distinct group of pancreatic neoplasms: an investigation of tumour cell differentiation and K-ras, p53 and c-erbB-2 abnormalities in 26 patients.
Intranuclear androgen receptor deployment and protooncogene expression in human diseased prostate.
Invasive ductal adenocarcinoma of the remnant pancreatic body 9 years after resection of an intraductal papillary-mucinous carcinoma of the pancreatic head: a case report and comparison of DNA sequence in K-ras gene mutation.
Inverse relationship between APC gene mutation in gastric adenomas and development of adenocarcinoma.
Investigation of c-myc and K-ras amplification in renal clear cell adenocarcinoma.
Involvement of APC and K-ras mutation in non-polypoid colorectal tumorigenesis.
Involvement of Chromatin Remodeling Genes and the Rho GTPases RhoB and CDC42 in Ovarian Clear Cell Carcinoma.
K-ras 4A and 4B are co-expressed widely in human tissues, and their ratio is altered in sporadic colorectal cancer.
K-ras activation and ras p21 expression in latent prostatic carcinoma in Japanese men.
K-ras activation in premalignant and malignant epithelial lesions of the human uterus.
K-ras activation occurs frequently in mucinous adenocarcinomas and rarely in other common epithelial tumors of the human ovary.
K-Ras and its inhibitors towards personalized cancer treatment: Pharmacological and structural perspectives.
K-Ras and microsatellite marker analysis of fine-needle aspirates from intraductal papillary mucinous neoplasms of the pancreas.
K-ras and p53 mutations and overexpressions as prognostic factors in female rectal carcinoma.
K-ras and p53 mutations in aberrant crypt foci and colonic tumors from colon cancer patients.
K-ras and p53 mutations in colonic lavage fluid of patients with colorectal neoplasias.
K-ras and p53 mutations in hamster pancreatic ductal adenocarcinomas and cell lines.
K-ras and p53 mutations in stage I gallbladder carcinoma with an anomalous junction of the pancreaticobiliary duct.
K-ras and rho A mutations in malignant pleural effusion.
K-ras and Wnt signaling synergize to accelerate prostate tumorigenesis in the mouse.
K-ras Asp12 mutant neither interacts with Raf, nor signals through Erk and is less tumorigenic than K-ras Val12.
K-ras codon 12 and 13 mutations are correlated with differential patterns of tumor cell dissemination in colorectal cancer patients.
K-ras codon 12 and p53 mutations in biopsy specimens and bile from biliary tract cancers.
K-ras codon 12 mutations may be detected in serum of patients suffering from adeno- and large cell lung carcinoma. A preliminary report.
K-ras exon 2 point mutations in human endometrial cancer.
K-ras gene mutation in colorectal adenomas and carcinomas from familial adenomatous polyposis patients.
K-ras gene mutation in early ductal lesions induced in a rapid production model for pancreatic carcinomas in Syrian hamsters.
K-ras gene mutation in gall bladder carcinomas and dysplasia.
K-ras gene mutation in the diagnosis of ultrasound guided fine-needle biopsy of pancreatic masses.
K-ras gene mutational analysis supports a monoclonal origin of biphasic pleomorphic carcinoma of the lung.
K-ras gene mutations and loss of heterozygosity at the p53 gene locus relative to histological characteristics of mucin-producing tumors of the pancreas.
K-ras gene mutations in adenomas and carcinomas of the colon.
K-ras gene mutations in intrahepatic bile duct tumors of Syrian golden hamsters.
K-ras Gene Mutations in Liver Carcinomas from a Mediterranean Area of Spain.
K-ras gene mutations in normal colorectal tissues from K-ras mutation-positive colorectal cancer patients.
K-ras gene point mutation: a stable tumor marker in non-small cell lung carcinoma.
K-RAS Mutant Gene Found in Pancreatic Juice Activated Chromatin From Peri-ampullary Adenocarcinomas.
K-ras mutation and loss of heterozygosity at 17p with beta-catenin accumulation in intramucosal carcinoma of the ileostomy in familial adenomatous polyposis: a case report.
K-ras mutation and loss of heterozygosity of the adenomatous polyposis coli gene in patients with colorectal adenomas with in situ carcinoma.
K-ras mutation and p53 protein accumulation in intraductal mucin-hypersecreting neoplasms of the pancreas.
K-ras mutation in adenomas and carcinomas of the ampulla of vater.
K-ras mutation in focal proliferative lesions of human pancreas.
K-ras mutation in human carcinoma after kidney transplantation.
K-ras mutation in sputum of primary lung cancer patients does not always reflect that of cancerous cells.
K-RAS mutation in transitional cell carcinoma of urinary bladder.
K-ras mutation influences macroscopic features of gastric carcinoma.
K-ras mutation is an early event in pancreatic duct carcinogenesis in the Syrian golden hamster.
K-ras mutation may promote carcinogenesis of endometriosis leading to ovarian clear cell carcinoma.
K-RAS mutation profile in Puerto Rican patients with colorectal cancer: trends from April 2009 to January 2011.
K-ras mutation, p53 overexpression, and microsatellite instability in biliary tract cancers: a population-based study in China.
K-ras mutations (codon 12) are not involved in down-regulation of MHC class-I genes in colon carcinomas.
K-ras mutations and p53 alterations in neoplastic and nonneoplastic lesions associated with longstanding ulcerative colitis.
K-ras mutations and prognosis in large-bowel carcinomas.
K-ras mutations and the diagnosis of pancreatic carcinoma.
K-ras mutations are a relatively late event in the pathogenesis of lung carcinomas.
K-ras mutations are correlated to lymph node metastasis and tumor stage, but not to the growth pattern of colon carcinoma.
K-ras mutations are frequent in pulmonary squamous cell carcinomas but not in adenocarcinomas of WBN/Kob rats induced by N-nitrosobis(2-oxopropyl)amine.
K-ras mutations at codon 12 are rare events in chronic pancreatitis.
K-ras mutations in 1,2-dimethylhydrazine-induced colonic tumors: effects of supplemental dietary calcium and vitamin D deficiency.
K-ras mutations in DNA extracted from the plasma of patients with pancreatic carcinoma: diagnostic utility and prognostic significance.
K-ras mutations in duodenal aspirate without secretin stimulation for screening of pancreatic and biliary tract carcinoma.
K-ras mutations in endometrial carcinomas with microsatellite instability.
K-ras mutations in gastric stump carcinomas and in carcinomas from the non-operated stomach.
K-RAS mutations in laryngeal squamous cell carcinoma.
K-ras mutations in lung carcinomas from nonsmoking women exposed to unvented coal smoke in China.
K-ras mutations in lung tumors and tumors from other organs are consistent with a common mechanism of ethylene oxide tumorigenesis in the B6C3F1 mouse.
K-ras mutations in mouse lung tumors of extreme age: independent of paternal preconceptional exposure to chromium(III) but significantly more frequent in carcinomas than adenomas.
K-ras mutations in non-small-cell lung carcinoma: a review.
K-ras mutations in sinonasal cancers in relation to wood dust exposure.
K-ras mutations in stools and tissue samples from patients with malignant and nonmalignant pancreatic diseases.
K-ras mutations in the duodenal fluid of patients with pancreatic carcinoma.
K-ras mutations in tissue and stool samples from patients with pancreatic cancer and chronic pancreatitis.
K-ras oncogene activation in adenocarcinoma of the human pancreas. A study of 82 carcinomas using a combination of mutant-enriched polymerase chain reaction analysis and allele-specific oligonucleotide hybridization.
K-ras oncogene mutations in rat colon tumors induced by N-methyl-N-nitrosourea.
K-ras p21 expression and activity in lung and lung tumors.
K-ras point mutation occurs in the early stage of carcinogenesis in lung cancer.
K-ras point mutations are rare events in premalignant forms of Barrett's oesophagus.
K-ras point mutations in routinely processed tissues: non-radioactive screening by single strand conformational polymorphism analysis.
K-ras point mutations in spontaneously occurring endometrial adenocarcinomas in the Donryu rat.
K-ras point mutations in the supernatants of pancreatic juice and bile are reliable for diagnosis of pancreas and biliary tract carcinomas complementary to cytologic examination.
K-ras status in squamous cell anal carcinoma (SCC): it's time for target-oriented treatment?
KRAS and BRAF mutations in ovarian tumors: a comprehensive study of invasive carcinomas, borderline tumors and extraovarian implants.
Lack of constitutive activation of MAP kinase pathway in human acute myeloid leukemia cells with N-Ras mutation.
Lack of elevated MAP kinase (Erk) activity in pancreatic carcinomas despite oncogenic K-ras expression.
Lack of ras mutations and prediction of long-term survival in carcinoma of the colon.
Late occurrence of K-ras gene mutations in the pathogenesis of squamous cell carcinoma of the lung: analysis in sputum.
Lin28-let7 modulates radiosensitivity of human cancer cells with activation of K-Ras.
Local cytokine treatment of HPV16-associated tumours results in inhibition of their lung metastases.
Localization of H-ras mRNA in oral squamous cell carcinomas.
Loss of growth control by TGF-beta occurs at a late stage of mouse skin carcinogenesis and is independent of ras gene activation.
Loss of heterozygosity and K-ras gene mutations in gastric cancer.
Loss of heterozygosity and microsatellite instability of the h-ras gene in cancer of the head and neck.
Loss of oncogenic ras expression does not correlate with loss of tumorigenicity in human cells.
Lovastatin, a cholesterol biosynthesis inhibitor, inhibits the growth of human H-ras oncogene transformed cells in nude mice.
Low frequency of alterations in p53, K-ras, and mdm2 in rat lung neoplasms induced by diesel exhaust or carbon black.
Low frequency of H-ras activation in naturally occurring hepatocellular tumors of C3H/HeNCr mice.
Low frequency of H-ras mutations in hepatocellular adenomas and carcinomas and in hepatoblastomas from B6C3F1 mice exposed to oxazepam in the diet.
Low frequency of p53 and k-ras codon 12 mutations in non-small cell lung carcinoma (NSCLC) tumors and surgical margins.
Low frequency of TERT promoter mutations in a series of well-differentiated follicular-patterned thyroid neoplasms.
Low incidence of point mutation at codon 12 of K-ras proto-oncogene in squamous cell carcinoma of the upper aerodigestive tract.
Low levels of ras p21 oncogene expression correlates with clinical outcome in head and neck squamous cell carcinoma.
Low mutational rate of K-ras codon 12 in singular bronchoscopy specimens in suspected lung cancer.
Lung cancer and past occupational exposure to asbestos. Role of p53 and K-ras mutations.
Maintenance of growth factor signaling through Ras in human colon carcinoma cells containing K-ras mutations.
Malignant activation of a K-ras oncogene in lung carcinoma but not in normal tissue of the same patient.
Map kinase activation correlates with K-ras mutation and loss of heterozygosity on chromosome 6 in alveolar bronchiolar carcinomas from B6C3F1 mice exposed to vanadium pentoxide for 2 years.
Mechanism of H-ras oncogene activation in mouse squamous carcinoma induced by an alkylating agent.
Mechanistic analysis of multistage carcinogenesis in the rat prostate.
Metachronous colorectal and biliary carcinoma: the aetiological implications of k-ras oncogenes.
Methylation of O(6)-methylguanine-DNA methyltransferase gene is associated significantly with K-ras mutation, lymph node invasion, tumor staging, and disease free survival in patients with gastric carcinoma.
microRNA-195-Cdc42 axis acts as a prognostic factor of esophageal squamous cell carcinoma.
MicroRNA-429 inhibits the proliferation and migration of esophageal squamous cell carcinoma cells by targeting RAB23 through the NF-?B pathway.
Microsatellite instability and K-ras mutations in gastric adenomas, with reference to associated gastric cancers.
miR-107 functions as a tumor suppressor in human esophageal squamous cell carcinoma and targets Cdc42.
miR-181a shows tumor suppressive effect against oral squamous cell carcinoma cells by downregulating K-ras.
MiR-181d functions as a potential tumor suppressor in oral squamous cell carcinoma by targeting K-ras.
miR-182-5p improves the viability, mitosis, migration, and invasion ability of human gastric cancer cells by down-regulating RAB27A.
MiR-196a binding-site SNP regulates RAP1A expression contributing to esophageal squamous cell carcinoma risk and metastasis.
MiR-206 functions as a tumor suppressor and directly targets K-Ras in human oral squamous cell carcinoma [Retraction].
MiR-206 functions as a tumor suppressor and directly targets K-Ras in human oral squamous cell carcinoma.
miR-28-5p acts as a tumor suppressor in renal cell carcinoma for multiple antitumor effects by targeting RAP1B.
miR-384 suppressed renal cell carcinoma cell proliferation and migration through targeting RAB23.
miR-518b is down-regulated, and involved in cell proliferation and invasion by targeting Rap1b in esophageal squamous cell carcinoma.
Modulation of mdr-1 expression by a H-ras oncogene in a human colon carcinoma cell line.
Molecular alterations in oral carcinogenesis: significant risk predictors in malignant transformation and tumor progression.
Molecular analysis of p53 and K-ras in lung carcinomas of coal miners.
Molecular analysis of ras oncogenes in CIN III and in stage I and II invasive squamous cell carcinoma of the uterine cervix.
Molecular carcinogenesis of endometrial cancer.
Molecular characteristics of poorly differentiated adenocarcinoma and signet-ring-cell carcinoma of colorectum.
Molecular cloning of rat Krev-1 cDNA and analysis of the mRNA levels in normal and NMU-induced mammary carcinomas.
Molecular diagnosis of pancreatic cancer.
Molecular genetic alterations in hamartomatous polyps and carcinomas of patients with Peutz-Jeghers syndrome.
Molecular genetic changes associated with colorectal carcinogenesis are not prognostic for tumor regression following preoperative chemoradiation of rectal carcinoma.
Molecular genetic changes in epithelial, stromal and mixed neoplasms of the endometrium.
Molecular genetic characterization of BRCA1- and BRCA2-linked hereditary ovarian cancers.
Molecular genetics and endometrial cancer.
Molecular markers for diagnostic cytology of neoplasms in the head region of the pancreas: mutation of K-ras and overexpression of the p53 protein product.
Molecular pathogenesis of pancreatic cancer.
Molecular Pathology of Endometrial Carcinoma: Practical aspects from the diagnostic and therapeutical view points.
Molecular pathology of endometrial carcinoma: transcriptional signature in endometrioid tumors.
Molecular pathology of endometrial hyperplasia and carcinoma.
Molecular pathology of invasive carcinoma.
Molecular pathways of urothelial development and bladder tumorigenesis.
Molecular profile of grade 3 endometrioid endometrial carcinoma: is it a type I or type II endometrial carcinoma?
Molecular profiles of EGFR, K-ras, c-met, and FGFR in pulmonary pleomorphic carcinoma, a rare lung malignancy.
Molecular profiling of sporadic colorectal tumors by microsatellite analysis.
Molecular target-based therapy of pancreatic cancer.
Morphological subtypes of ovarian carcinoma: a review with emphasis on new developments and pathogenesis.
MSX2 in pancreatic tumor development and its clinical application for the diagnosis of pancreatic ductal adenocarcinoma.
Mucinous and nonmucinous appendiceal adenocarcinomas: different clinicopathological features but similar genetic alterations.
Mucinous carcinomas of the colorectum have distinct molecular genetic characteristics.
Mucinous cystic carcinoma of the pancreas: a unique cell line and xenograft model of a preinvasive lesion.
Multiple K-ras mutations in hyperplasia and carcinoma in cases of human pancreatic carcinoma.
Multiple loss of heterozygosity without K-ras mutation identified by molecular analysis on fine-needle aspiration cytology specimen of acinar cell carcinoma of pancreas.
Multiple stages in radiation carcinogenesis of rat skin.
Multiplex PCR/LDR for detection of K-ras mutations in primary colon tumors.
Multistage prostate carcinogenesis: the role of hormones.
Murine squamous cell carcinoma cell lines produced by a complete carcinogenesis protocol with benzo[a]pyrene exhibit characteristic p53 mutations and the absence of H-ras and cyl 1/cyclin D1 abnormalities.
Mutant K-ras promotes carcinogen-induced murine colorectal tumourigenesis, but does not alter tumour chromosome stability.
Mutant K-ras regulates cathepsin B localization on the surface of human colorectal carcinoma cells.
Mutant ras oncogenes upregulate VEGF/VPF expression: implications for induction and inhibition of tumor angiogenesis.
Mutated K-ras gene analysis in a randomized trial of preoperative chemotherapy plus surgery versus surgery in stage IIIA non-small cell lung cancer.
Mutated K-ras(Asp12) promotes tumourigenesis in Apc(Min) mice more in the large than the small intestines, with synergistic effects between K-ras and Wnt pathways.
Mutation analysis of K-ras and beta-catenin genes related to O6-methylguanin-DNA methyltransferase and mismatch repair protein status in human gallbladder carcinoma.
Mutation of K-RAS protooncogene and loss of heterozygosity on 6q27 in serous and mucinous ovarian carcinomas.
Mutation of K-ras protooncogene in human ovarian epithelial tumors of borderline malignancy.
Mutation of K-ras protooncogene is associated with histological subtypes in human mucinous ovarian tumors.
Mutation of the nm23 gene, loss of heterozygosity at the nm23 locus and K-ras mutation in ovarian carcinoma: correlation with tumour progression and nm23 gene expression.
Mutation Spectra of Kras and Tp53 in Urethral and Lung Neoplasms in B6C3F1 Mice Treated with 3,3',4,4'-Tetrachloroazobenzene.
Mutational activation of c-Ha-ras genes in intraductal proliferation induced by N-nitroso-N-methylurea in rat mammary glands.
Mutational activation of the K-ras oncogene. A possible pathogenetic factor in adenocarcinoma of the lung.
Mutational analysis of BRAF in gallbladder carcinomas in association with K-ras and p53 mutations and microsatellite instability.
Mutational analysis of K-ras and Ras protein expression in larynx squamous cell carcinoma.
Mutational analysis of K-ras segregates ovarian serous carcinomas into two types: invasive MPSC (low-grade tumor) and conventional serous carcinoma (high-grade tumor).
Mutational analysis of the p53 and K-ras genes and allelotype study of the Rb-1 gene for investigating the pathogenesis of combined hapatocellular-cholangiocellular carcinomas.
Mutational status of codons 12 and 13 of the N- and K-ras genes in tissue and cell lines derived from primary and metastatic prostate carcinomas.
Mutations in an alternatively spliced exon of h-ras are not associated with loss of heterozygosity on chromosome 11p15.5 in ovarian tumorigenesis.
Mutations in the K-ras oncogene induced by 1,2-dimethylhydrazine in preneoplastic and neoplastic rat colonic mucosa.
Mutations of K-ras but not p53 genes in biliary duct and pancreatic duct carcinomas induced in hamsters by cholecystoduodenostomy with dissection of the common duct followed by N-nitrosobis(2-oxopropyl)amine.
Mutations of K-ras oncogene and absence of H-ras mutations in squamous cell carcinomas of the lung.
Mutations of the K-ras and p53 genes in gastric adenocarcinomas from a high-incidence region around Florence, Italy.
Mutations, expression and genomic instability of the H-ras proto-oncogene in squamous cell carcinomas of the head and neck.
Mutually exclusive mutations of the Pten and ras pathways in skin tumor progression.
Neoplastic transformation of human keratinocytes by polybrene-induced DNA-mediated transfer of an activated oncogene.
Neratinib inhibits Hippo/YAP signaling, reduces mutant K-RAS expression, and kills pancreatic and blood cancer cells.
Neurotensin and EGF induce synergistic stimulation of DNA synthesis by increasing the duration of ERK signaling in ductal pancreatic cancer cells.
New concepts in the diagnosis and prognosis of endometrial carcinoma.
New Variations in the Promoter Regions of Human DOCK4 and RAP1A Genes, and Coding Regions of RAP1A in Sporadic Breast Tumors.
NGAL decreases E-cadherin-mediated cell-cell adhesion and increases cell motility and invasion through Rac1 in colon carcinoma cells.
NIH3T3 transfectant containing human K-ras oncogene shows enhanced metastatic activity after in vivo tumor growth or co-culture with fibroblasts.
No occurrence of DNA-polymerase Beta-gene mutation in human lung-carcinoma cell-lines with k-ras as, p53, or rb gene alterations.
Non-Epstein-Barr virus associated lymphoepithelioma-like carcinoma of the esophagogastric junction with microsatellite instability, K-ras wild type.
Non-involvement of the K-ras mutation in colon carcinogenesis promoted by dietary deoxycholate in azoxymethane-treated rats.
Non-radioactive detection of K-ras mutations by nested allele specific PCR and oligonucleotide hybridization.
Nonfunctioning islet cell carcinoma of the pancreas with high serum CEA & CA19-9, K-ras codon 12 mutation, and microsatellite instability.
Novel molecular profiles of endometrial cancer-new light through old windows.
NTP toxicology and carcinogensis studies of vanadium pentoxide (CAS No. 1314-62-1) in F344/N rats and B6C3F1 mice (inhalation).
Nuclear expression of S100A4 is associated with aggressive behavior of epithelial ovarian carcinoma: An important autocrine/paracrine factor in tumor progression.
Nucleolar localization of Small G protein RhoA is associated with active RNA synthesis in human carcinoma HEp-2 cells.
o-Nitrotoluene-induced large intestinal tumors in B6C3F1 mice model human colon cancer in their molecular pathogenesis.
O6-methylguanine-DNA methyltransferase promoter hypermethylation in colorectal carcinogenesis.
Occurrence of ras mutations in human lung cancer. Minireview.
Oligomycins as inhibitors of K-Ras plasma membrane localisation.
Oncogene activation in experimental carcinogenesis: the role of carcinogen and tissue specificity.
Oncogene amplification in squamous cell carcinoma of the head and neck.
Oncogene amplification in squamous cell carcinoma of the oral cavity.
Oncogene involvement in tumor regression: H-ras activation in the rabbit keratoacanthoma model.
Oncogenes in head and neck cancer.
Oncogenic effects of RAB27B through exosome independent function in renal cell carcinoma including sunitinib-resistant.
Oncogenic K-ras activates p38 to maintain colorectal cancer cell proliferation during MEK inhibition.
Oncogenic K-Ras down-regulates Rac1 and RhoA activity and enhances migration and invasion of pancreatic carcinoma cells through activation of p38.
Oncogenic K-RAS is required to maintain changes in cytoskeletal organization, adhesion, and motility in colon cancer cells.
Oncogenic Ras modulates epidermal growth factor responsiveness in endometrial carcinomas.
Osteoclast-like giant cell tumor of the pancreas with metastases to gallbladder and lymph nodes. A case report.
Ovarian clear cell carcinomas: RHO GTPases may contribute to explain their singular biologic behavior.
Ovarian small cell carcinoma with K-ras mutation: a case report with genetic analysis.
Overexpression of p53 protein and point mutation of K-ras genes in primary carcinoma of the small intestine.
Overexpression of p53 protein in adenocarcinoma of the pancreas.
Overexpression of Rac-1 small GTPase binding protein in oral squamous cell carcinoma.
Overexpression of RIN1 associates with tumor grade and progression in patients of bladder urothelial carcinoma.
Overexpression of the BRIP1 ameliorates chemosensitivity to cisplatin by inhibiting Rac1 GTPase activity in cervical carcinoma HeLa cells.
Overexpression of the p53 tumor suppressor gene product in primary lung adenocarcinomas is associated with cigarette smoking.
Overexpression of the rhoC gene correlates with progression of ductal adenocarcinoma of the pancreas.
Overlapping functions of Ras and Rac GTPases in regulating cancer cell proliferation and invasion.
p16 and K-ras gene mutations in the intraductal precursors of human pancreatic adenocarcinoma.
p53 and H-ras mutations and microsatellite instability in renal pelvic carcinomas of NON / Shi mice treated with N-butyl-N-(4-hydroxybutyl)-nitrosamine: different genetic alteration from urinary bladder carcinoma.
p53 and K-ras gene mutations in carcinoma of the rectum among Finnish women.
p53 and K-ras mutational genotyping in pulmonary carcinosarcoma, spindle cell carcinoma, and pulmonary blastoma: implications for histogenesis.
P53 and K-ras mutations are frequent events in microscopically negative surgical margins from patients with nonsmall cell lung carcinoma.
p53 and K-ras mutations in lung tissues and sputum samples of individuals exposed to smoky coal emissions in Xuan Wei County, China.
p53 and p21/Waf1 protein expression and K-ras codon 12 mutation in carcinoma of the papilla of Vater.
p53 and ras gene mutations in lung cancer: implications for smoking and occupational exposures.
p53 mutations in early neoplastic lesions of the urinary bladder in rats treated with N-butyl-N-(4-hydroxybutyl)nitrosamine.
p53 mutations in transitional cell carcinomas of the urinary bladder in rats treated with N-butyl-N-(4-hydroxybutyl)-nitrosamine.
p53 mutations, ras mutations, and p53-heat shock 70 protein complexes in human lung carcinoma cell lines.
p53 protein overexpression and K-ras codon 12 mutation in pancreatic ductal carcinoma: correlation with histologic factors.
Paired-like homeoprotein ESXR1 acts as a sequence-specific transcriptional repressor of the human K-ras gene.
Pancreatic adenocarcinomas with DNA replication errors (RER+) are associated with wild-type K-ras and characteristic histopathology. Poor differentiation, a syncytial growth pattern, and pushing borders suggest RER+.
Pancreatic cancer cell radiation survival and prenyltransferase inhibition: the role of K-Ras.
Pancreatic lymph nodal and plexus micrometastases detected by enriched polymerase chain reaction and nonradioisotopic single-strand conformation polymorphism analysis: a new predictive factor for recurrent pancreatic carcinoma.
Pancreatic tumor cells with mutant K-ras suppress ERK activity by MEK-dependent induction of MAP kinase phosphatase-2.
Partial suppression of tumorigenicity in a human lung cancer cell line transfected with Krev-1.
Pathology and proliferative activity of renal-cell carcinomas (RCCS) and renal oncocytomas in patients with different radiation exposure after the Chernobyl accident in Ukraine.
Pathology of Endometrial Carcinoma.
Pathophysiological effects of nicotine on the pancreas: an update.
PCR amplification and analysis of ras oncogenes from thyroid cytologic smears.
pERK activation in esophageal carcinomas: clinicopathological associations.
Phase I first-in-human study of HLX07, a novel and improved recombinant anti-EGFR humanized monoclonal antibody, in patients with advanced solid cancers.
Phenotypic classification of gastric signet ring cell carcinoma and its relationship with K-ras mutation.
Phospholipase D provides a survival signal in human cancer cells with activated H-Ras or K-Ras.
Polypoid growth and K-ras codon 12 mutation in colorectal cancer.
Possible role of activated ras genes in human esophageal carcinogenesis.
Preferential and novel activation of H-ras in human bladder carcinomas.
Prerequisites for effective adenovirus mediated gene therapy of colorectal liver metastases in the rat using an intracellular neutralizing antibody fragment to p21-Ras.
Presence of activated ras correlates with increased cysteine proteinase activities in human colorectal carcinomas.
Presence of ras oncogene mutations and human papillomavirus DNA in human prostate carcinomas.
Prevalence and clinical significance of combined K-ras mutation and p53 aberration in pancreatic adenocarcinoma.
Prevalence of activating K-ras mutations in the evolutionary stages of neoplasia in intraductal papillary mucinous tumors of the pancreas.
Prevalence of K-ras Codon 12 Mutations in Indian Patients with Head and Neck Cancer.
Prevalence of K-RAS Codons 12 and 13 Mutations in Locally Advanced Head and Neck Squamous Cell Carcinoma and Impact on Clinical Outcomes.
Prevalence of K-RAS mutations and CA125 tumor marker in patients with ovarian carcinoma.
Prevalences of Gs alpha, ras, p53 mutations and ret/PTC rearrangement in differentiated thyroid tumours in a Korean population.
Prevention of orthotopic human lung cancer growth by intratracheal instillation of a retroviral antisense K-ras construct.
Production of spindle cell carcinoma by transduction of H-Ras 61L into immortalized human mammary epithelial cells.
Prognostic impact of mutated K-ras gene in surgically resected non-small cell lung cancer patients.
Prognostic relevance of increased Rac GTPase expression in prostate carcinomas.
Prognostic role of Rab27A and Rab27B expression in patients with non-small cell lung carcinoma.
Prognostic significance of K-ras and TP53 mutations in the role of adjuvant chemotherapy on survival in patients with Dukes C colon cancer.
Prognostic significance of K-ras codon 12 mutations in patients with resected stage I and II non-small-cell lung cancer.
Prognostic significance of K-ras, p53, bcl-2, PCNA, CD34 in radically resected non-small cell lung cancers.
Prognostic significance of molecular markers in oral squamous cell carcinoma: A multivariate analysis.
Prognostic value of CpG island hypermethylation at PTGS2, RAR-beta, EDNRB, and other gene loci in patients undergoing radical prostatectomy.
Prognostic value of genetically diagnosed lymph node micrometastasis in non-small cell lung carcinoma cases.
Progression and multiple events in radiation carcinogenesis of rat skin.
Progression of squamous carcinoma cells to spindle carcinomas of mouse skin is associated with an imbalance of H-ras alleles on chromosome 7.
Proliferative heterogeneity of human renal cell carcinomas and prevalence of ras gene point mutations.
Proliferative potential and K-ras mutation in epithelial hyperplasia of the gallbladder in patients with anomalous pancreaticobiliary ductal union.
Proteome of Metastatic Canine Mammary Carcinomas: Similarities to and Differences from Human Breast Cancer (†).
pS2 expression as a possible diagnostic marker of colorectal carcinoma in ulcerative colitis.
PTEN mutation, expression and LOH at its locus in ovarian carcinomas. Relation to TP53, K-RAS and BRCA1 mutations.
Quantification of Tumor Burden in a Genetically Engineered Mouse Model of Lung Cancer by Micro-CT and Automated Analysis.
Quantitating the frequency of initiation and cH-ras mutation in in situ N-methyl-N-nitrosourea-exposed rat mammary gland.
Quantity of mutant K-ras gene in pancreatic secretions for diagnosis of pancreatic carcinoma with different assays: analysis of 100 patients.
Rab11 Functions as an Oncoprotein via Nuclear Factor kappa B (NF-?B) Signaling Pathway in Human Bladder Carcinoma.
Rab18 is not necessary for lipid droplet biogenesis or turnover in human mammary carcinoma cells.
Rab18 Regulates Proliferation, Invasion and Cisplatin Sensitivity Through STAT3 Signaling in Head and Neck Squamous Cell Carcinoma.
Rab23 promotes squamous cell carcinoma cell migration and invasion via integrin ?1/Rac1 pathway.
RAB23, regulated by miR-92b, promotes the progression of esophageal squamous cell carcinoma.
RAB27A is an independent prognostic factor in clear cell renal cell carcinoma.
Rab27a supports exosome-dependent and -independent mechanisms that modify the tumor microenvironment and can promote tumor progression.
Rac1 activation inhibits E-cadherin-mediated adherens junctions via binding to IQGAP1 in pancreatic carcinoma cells.
Radiation-associated and 'spontaneous' human thyroid carcinomas show a different pattern of ras oncogene mutation.
Radiation-stimulated ERK1/2 and JNK1/2 signaling can promote cell cycle progression in human colon cancer cells.
Ral GTPase Activation by Downregulation of RalGAP Enhances Oral Squamous Cell Carcinoma Progression.
RalA regulates vascular endothelial growth factor-C (VEGF-C) synthesis in prostate cancer cells during androgen ablation.
Rap1A promotes esophageal squamous cell carcinoma metastasis through the AKT signaling pathway.
RAP1B, a DVL2 binding protein, activates Wnt/beta-catenin signaling in esophageal squamous cell carcinoma.
Rap2A Is Upregulated in Invasive Cells Dissected from Follicular Thyroid Cancer.
Rap2a serves as a potential prognostic indicator of renal cell carcinoma and promotes its migration and invasion through up-regulating p-Akt.
Rapid detection of K-ras gene mutations in canine lung cancer using single-strand conformational polymorphism analysis.
Rapid detection of ras oncogenes in human tumors: applications to colon, esophageal, and gastric cancer.
Rapid development of salivary gland carcinomas upon conditional expression of K-ras driven by the cytokeratin 5 promoter.
Rare occurrence of ras and p53 gene mutations in mouse stomach tumors induced by N-methyl-N-nitrosourea.
ras activation in human tumors and in animal model systems.
ras and myc analysis in primary and metastatic colorectal carcinomas.
Ras CAAX peptidomimetic FTI 276 selectively blocks tumor growth in nude mice of a human lung carcinoma with K-Ras mutation and p53 deletion.
ras gene activation and infrequent mutation in papillary serous carcinoma of the peritoneum.
ras gene alterations in invasive and non-invasive rat bladder carcinomas induced by N-methyl-N-nitrosourea.
Ras gene mutation is not related to tumour invasion during rat tongue carcinogenesis induced by 4-nitroquinoline 1-oxide.
ras gene mutations and HPV infection are common in human laryngeal carcinoma.
Ras gene point mutations in gallbladder lesions associated with anomalous connection of pancreatobiliary ducts.
Ras involvement in cells transformed with 2-amino-4-(5-nitro-2-furyl)thiazole (ANFT) in vitro and with N-[4-(5-nitro-2-furyl)-2-thiazoyl]formamide in vivo.
Ras mutation, irrespective of cell type and p53 status, determines a cell's destiny to undergo apoptosis by okadaic acid, an inhibitor of protein phosphatase 1 and 2A.
RAS Mutations Affect Tumor Necrosis Factor-Induced Apoptosis in Colon Carcinoma Cells via ERK-Modulatory Negative and Positive Feedback Circuits Along with Non-ERK Pathway Effects.
ras mutations and expression in head and neck squamous cell carcinomas.
RAS Mutations Are the Predominant Molecular Alteration in Poorly Differentiated Thyroid Carcinomas and Bear Prognostic Impact.
Ras oncogene activation during hepatocarcinogenesis in B6C3F1 male mice by dichloroacetic and trichloroacetic acids.
Ras p21 in breast tissue: associations with pathology and cellular localisation.
Recruitment of Tiam1 to Semaphorin 4D Activates Rac and Enhances Proliferation, Invasion, and Metastasis in Oral Squamous Cell Carcinoma.
Redox regulation of ephrin/integrin cross-talk.
Regulation of pancreatic cancer growth by superoxide.
Relation between the occurrence of K-ras gene point mutations and genotypes of polymorphic N-acetyltransferase in human colorectal carcinomas.
Relationship between K-ras mutation and the expression of p21WAF1/CIP1 and p53 in chronic pancreatitis and pancreatic adenocarcinoma.
Relationship of family cancer history to the expression of p53, p21WAF-1, HER-2/neu, and K-ras mutation in pancreatic adenocarcinoma.
Relationship of the K-ras/c-mos expression patterns with angiogenesis in non-small cell lung carcinomas.
Remission of acromegaly caused by pituitary carcinoma after surgical excision of growth hormone-secreting metastasis detected by 111-indium pentetreotide scan.
Results of a Phase I Trial of 12 Patients With Locally Advanced Pancreatic Carcinoma Combining Gefitinib, Paclitaxel, and 3-Dimensional Conformal Radiation: Report of Toxicity and Evaluation of Circulating K-ras as a Potential Biomarker of Response to Therapy.
Retroviral vector-mediated transduction of K-ras antisense RNA into human lung cancer cells inhibits expression of the malignant phenotype.
Reversal of the malignant phenotype by an anti-ras ribozyme.
RhoA/ROCK-mediated switching between Cdc42- and Rac1-dependent protrusion in MTLn3 carcinoma cells.
Ribozyme against mutant K-ras mRNA suppresses tumor growth of pancreatic cancer.
Ribozyme as an approach for growth suppression of human pancreatic cancer.
Risk for K-ras gene mutations in smoking-induced lung cancer is associated with cytochrome P4501A1 and glutathione S-transferase micro1 polymorphisms.
Role of ARHGAP24 in ADP Ribosylation Factor 6 (ARF6)-dependent Pseudopod Formation in Human Breast Carcinoma Cells.
Role of the DPC4 tumor suppressor gene in adenocarcinoma of the ampulla of Vater: analysis of 140 cases.
S100A7 has an oncogenic role in oral squamous cell carcinoma by activating p38/MAPK and RAB2A signaling pathway.
Screening of H-ras gene point mutations in 50 cases of bladder carcinoma.
Second primary or recurrence? Comparative patterns of p53 and K-ras mutations suggest that serous borderline ovarian tumors and subsequent serous carcinomas are unrelated tumors.
Selective occurrence of ras mutations in benign and malignant thyroid follicular neoplasms in Taiwan.
Sequential accumulation of K-ras mutations and p53 overexpression in the progression of pancreatic mucinous cystic neoplasms to malignancy.
Significance of K-ras codon 12 point mutation in pancreatic juice in the diagnosis of carcinoma of the pancreas.
Significance of K-ras mutation and CEA level in pancreatic juice in the diagnosis of pancreatic cancer.
Silencing Ras-Related C3 Botulinum Toxin Substrate 1 Inhibits Growth and Migration of Hypopharyngeal Squamous Cell Carcinoma via the P38 Mitogen-Activated Protein Kinase Signaling Pathway.
Similar incidence of K-ras mutations in lung carcinomas of FVB/N mice and FVB/N mice carrying a mutant p53 transgene.
Single-Pattern Convergence of K-ras Mutation Correlates With Surgical Indication of Intraductal Papillary Mucinous Neoplasms.
Sirt1 protects from K-Ras-driven lung carcinogenesis.
Smad7 is required for TGF-beta-induced activation of the small GTPase Cdc42.
Small cell carcinoma of the gallbladder: a clinicopathologic, immunohistochemical, and molecular pathology study of 12 cases.
Small GTPase RhoE/Rnd3 Is a Critical Regulator of Notch1 Signaling.
Small interfering RNAs targeting mutant K-ras inhibit human pancreatic carcinoma cells growth in vitro and in vivo.
SmgGDS regulates cell proliferation, migration, and NF-kappaB transcriptional activity in non-small cell lung carcinoma.
Smoking, oncogenes and human lung cancer. A review of recent laboratory evidence linking smoking and lung cancer.
Smurf1 regulation of DAB2IP controls cell proliferation and migration.
Soluble normal and mutated DNA sequences from single-copy genes in human blood.
Somatic alterations of the serine/threonine kinase LKB1 gene in squamous cell (SCC) and large cell (LCC) lung carcinoma.
Somatic APC and K-ras codon 12 mutations in periampullary adenomas and carcinomas from familial adenomatous polyposis patients.
Somatic mutations of the ERBB4 kinase domain in human cancers.
Spatiotemporal metabolic dynamics of the photosensitizer talaporfin sodium in carcinoma and sarcoma.
Specific cross-talk between epidermal growth factor receptor and integrin alphavbeta5 promotes carcinoma cell invasion and metastasis.
Spheroid assay to measure TGF-?-induced invasion.
Splicing variant of Cdc42 interacting protein-4 disrupts beta-catenin-mediated cell-cell adhesion: expression and function in renal cell carcinoma.
Studies on the Contribution of Cox-2 Expression in the Progression of Oral Squamous Cell Carcinoma and H-Ras Activation.
Supplemental dietary calcium fails to alter the acute effects of 1,2-dimethylhydrazine on O6-methylguanine, O6-alkylguanine-DNA alkyltransferase and cellular proliferation in the rat colon.
Suppression of EJ cells tumorigenicity.
Survivin depletion preferentially reduces the survival of activated K-Ras-transformed cells.
Synchronous adenocarcinomas of intestinal type of the inner nose and the colon.
Synchronous colorectal cancer: clinical, pathological and molecular implications.
Synergism between K-rasVal12 and mutant Apc accelerates murine large intestinal tumourigenesis.
Synergistic effect of MNU and DMBA in mammary carcinogenesis and H-ras activation in female Sprague-Dawley rats.
The Adaptor Protein and Arf GTPase-activating Protein Cat-1/Git-1 Is Required for Cellular Transformation.
The amplification of c-erb-B2 in cancer-free surgical margins is a predictor of poor outcome in oral squamous cell carcinoma.
The association of K-ras gene mutation and vascular endothelial growth factor gene expression in pancreatic carcinoma.
The association of the H-ras oncogene and steroid hormone receptors in gynecological cancer.
The balanced induction of K-ras codon 12 and 13 mutations in mucosa differs from their ratio in neoplastic tissues.
The Efficacy of IGF-I Receptor Monoclonal Antibody against Human Gastrointestinal Carcinomas is Independent of k-ras Mutation Status.
The frequency of p53, K-ras mutations, and microsatellite instability differs in uterine endometrioid and serous carcinoma: evidence of distinct molecular genetic pathways.
The genetics of colorectal cancer.
The grab-and-drop protocol: a novel strategy for membrane protein isolation and reconstitution from single cells.
The K-ras gene regulates vascular endothelial growth factor gene expression in non-small cell lung cancers.
The let-7a microRNA protects from growth of lung carcinoma by suppression of k-Ras and c-Myc in nude mice.
The potential diagnostic use of K-ras codon 12 and p53 alterations in brush cytology from the pancreatic head region.
The presence of K-12 ras mutations in duodenal adenocarcinomas and the absence of ras mutations in other small bowel adenocarcinomas and carcinoid tumors.
The radiosensitivity of human keratinocytes: influence of activated c-H-ras oncogene expression and tumorigenicity.
The relationship between microvessel count and the expression of vascular endothelial growth factor, p53, and K-ras in non-small cell lung cancer.
The relevance of oncogenes as prognostic markers in cervical cancer.
The Rho GTPase RhoE exerts tumor-suppressing effects in human esophageal squamous cell carcinoma via negatively regulating epidermal growth factor receptor.
The Rho GTPase signalling pathway in urothelial carcinoma.
The role of circulating tumor cells and K-ras mutations in patients with locally advanced rectal cancer: a prospective study.
The role of p21ras in pancreatic neoplasia and chronic pancreatitis.
The sequential accumulation of genetic alterations characteristic of the colorectal adenoma-carcinoma sequence does not occur between gastric adenoma and adenocarcinoma.
The small GTPase RhoA has greater expression in small cell lung carcinoma than in non-small cell lung carcinoma and contributes to their unique morphologies.
Therapeutic efficacy of an adenovirus-mediated anti-H-ras ribozyme in experimental bladder cancer.
Thromboxane A2 receptors in prostate carcinoma: expression and its role in regulating cell motility via small GTPase Rho.
Time-dependent biological differences in molecular markers of high-grade urothelial cancer over 7 decades (ras proteins, pTEN, uPAR, PAI-1 and MMP-9).
Tissue factor expression in non-small cell lung cancer: relationship with vascular endothelial growth factor expression, microvascular density, and K-ras mutation.
TP53 and p16INK4A, but not H-KI-Ras, are involved in tumorigenesis and progression of pleomorphic adenomas.
Transcriptional regulation of the interleukin-11 gene by oncogenic Ras.
Transforming growth factor beta1, ras and p53 in silica-induced fibrogenesis and carcinogenesis.
Trimodality treatment in Stage III nonsmall cell lung carcinoma: prrognostic impact of K-ras mutations after neoadjuvant therapy.
TSAP6 is a novel candidate marker of poor survival in metastatic high-grade serous carcinoma.
Tumor suppression by p27Kip1 and p21Cip1 during chemically induced skin carcinogenesis.
UBIAD1 suppresses the proliferation of bladder carcinoma cells by regulating H-Ras intracellular trafficking via interaction with the C-terminal domain of H-Ras.
Update on the molecular profile of the MDA-MB-453 cell line as a model for apocrine breast carcinoma studies.
Upregulation of non-mutated H-ras and its upstream and downstream signaling proteins in colorectal cancer.
Use of ras-transformed human ovarian surface epithelial cells as a model for studying ovarian cancer.
Use of spontaneous Epstein-Barr virus-lymphoblastoid cell lines genetically modified to express tumor antigen as cancer vaccines: mutated p21 ras oncogene in pancreatic carcinoma as a model.
Usefulness of supernatant of pancreatic juice for genetic analysis of K-ras in diagnosis of pancreatic carcinoma.
Validation of the Point-EXACCT method in non-small cell lung carcinomas.
Vascular endothelial growth factor and nitric oxide synthase expression in human lung cancer and the relation to p53.
Vascular endothelial growth factor, p53, and the H-ras oncogene in Egyptian patients with bladder cancer.
Villous, hypermucinous mucosa in long standing ulcerative colitis shows high frequency of K-ras mutations.
What is the true rate of K-ras mutation in carcinoma of the pancreas?
Wild-type K-ras has a tumour suppressor effect on carcinogen-induced murine colorectal adenoma formation.
Wnt5b promotes the cell motility essential for metastasis of oral squamous cell carcinoma through active Cdc42 and RhoA.
[A resected case of metastatic pancreatic cancer from cecal carcinoma]
[Advance in the biology of pancreatic of cancer].
[Age-related and clinical-pathogenetic features of colorectal cancer associated with status of K-ras gene].
[Alteration of the K-ras and p16/CDKN2 gene in endocrine pancreatic carcinomas]
[An application value of detecting K-ras and p53 gene mutation in the stool and pure pancreatic juice for diagnosis of early pancreatic cancer]
[Anatomopathological tools for screening and medical surveillance of people exposed to asbestos]
[Carcinogenesis and its mechanism of mutant-type[12Asp]K-ras4B gene]
[Cell kinetics of colorectal tumors with assessment by K-ras mutation and PCNA labeling index]
[Clinical significance of p21H-ras expression and H-ras codon 12 mutation in squamous intraepithelial lesion (SIL) and carcinoma of uterine cervix]
[Combined detection of K-ras mutation and CA19-9 level in plasma of patients with pancreatic cancer]
[Current options and principles of pathomorphology-based tumour diagnostics]
[Detection of hepatic micrometastasis in ductal pancreatic carcinoma by K-ras mutation analysis and determination of clinical relevance]
[Detection of K-ras mutation from malignant cells in sputum with mutant-allele specific amplification (MASA) method]
[Detection of K-ras oncogene activation in human lung cancer and its possible clinical application]
[Detection of mutations of the K-ras gene in condensed breath of patients with non-small-cell lung carcinoma (NSCLC) as a possible noninvasive screening method]
[Detection of point mutation of K-ras gene codon 12 in biliary tract and ampullary carcinoma by modified two-step polymerase chain reaction]
[Detection of ras gene mutations of pancreatic tumors by polymerase chain reaction and direct sequencing method]
[Differential genetic pathway of duct and acinar carcinomas of the pancreas]
[Dualistic model of molecular pathogenesis in endometrial carcinoma]
[Effect of PCBs on mouse lung tumorigenesis induced by 1-nitropyrene: a preliminary report]
[Effect of shRNA-mediated silence of H-ras gene on proliferation of human SACC-M cells]
[Endometrial carcinoma and precursor lesions]
[Findings of genetic changes in small intestinal carcinomas]
[Frequency of K-ras mutation in biliary and pancreatic tumors.]
[General rules for the study of pancreatic cancer by molecular biological aspect]
[Genetic alterations and transformations in development and establishment of uterine endometrial carcinomas]
[Genetic alterations in gallbladder carcinoma: a review]
[Genetic investigations for lung carcinoma]
[Genetics and environmental factors in gastric carcinogenesis]
[Immunohistochemical study of growth factors and oncogenes in gastric carcinomas]
[K-ras gene mutation in gallbladder carcinoma]
[K-ras mutation analysis in ovarian serous borderline and malignant tumors]
[K-ras mutation in pancreatic juice from patients with pancreatic carcinoma]
[K-ras mutations in rectal cancer undergone preoperative radiotherapy]
[Microdissection and PCR-SSCP detected mutation and expression of p53 and K-ras gene in carcinogenesis and development of induced rat lung carcinoma]
[Molecular diagnosis of pancreatic cancer]
[Molecular, genetic and immunohistochemical investigation of carcinosarcoma of the female reproductive tract]
[Mutation analysis of K-ras protooncogene in colorectal adenocarcinomas and polyps in Russian patients]
[Mutation of the K-ras oncogene in pancreatic carcinoma, and application of its detection in pancreatic juice to diagnose pancreatic carcinoma]
[Mutations of APC and K-ras gene in aberrant crypt foci from human colon]
[New molecular targets in pancreatic cancer]
[Oncogenes and anti-oncogenes in lung cancer]
[Outcomes of patients with small bowel carcinoma treated with appropriate chemotherapy selected on the basis of genetic analysis findings].
[Point mutation of K-ras gene in pancreatic carcinoma]
[Precancerous lesion in colorectal cancer]
[Prevalence of K-ras gene mutations in human colorectal cancers]
[Progress and prospect in basic and clinical lung cancer researches]
[Sensitive detection of K-ras oncogene codon 12 mutations by nested PCR using mismatched primers and selective digestion of non-mutated PCR fragments with restriction enzyme]
[Serous genital carcinoma : Molecular pathogenesis and the role of tubal fimbria.]
[Significance of detection of K-ras gene mutations and CA19-9 in serum for diagnosis of pancreatic carcinoma]
[The diagnostic value of serum carcinoma markers, fecal K-ras and p53 gene mutation in pancreatic cancers]
[The expressions of K-ras in human laryngeal squamous cell carcinoma cell lines (Hep-2) and its significance]
[The study of the effect of antisense oligonucleotide specific to K-ras point mutation on human pancreatic carcinoma cell PC-2]
[Transformation of NIH/3T3 cells and SW 480 cells displaying K-ras mutation]
Carcinoma in Situ
Black tea extract can modulate protein expression of H-ras, c-Myc, p53, and Bcl-2 genes during pulmonary hyperplasia, dysplasia, and carcinoma in situ.
Clinicopathological observations of colorectal serrated lesions associated with invasive carcinoma and high-grade intraepithelial neoplasm.
Differential expression of cell cycle regulators in phenotypic variants of transgenically induced bladder tumors: implications for tumor behavior.
H-ras oncogene mutations during development of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced rat mammary gland cancer.
Harvey ras (H-ras) point mutations are induced by 4-nitroquinoline-1-oxide in murine oral squamous epithelia, while squamous cell carcinomas and loss of heterozygosity occur without additional exposure.
Inflammation and mitochondrial fatty acid beta-oxidation link obesity to early tumor promotion.
Irreversible and sustained upregulation of endothelin axis during oncogene-associated pancreatic inflammation and cancer.
K-ras mutation is an early event in pancreatic duct carcinogenesis in the Syrian golden hamster.
Molecular genetics of exocrine pancreatic neoplasms.
Molecular pathways of urothelial development and bladder tumorigenesis.
[Serous genital carcinoma : Molecular pathogenesis and the role of tubal fimbria.]
Carcinoma, Acinar Cell
Molecular pathology of invasive carcinoma.
Multiple loss of heterozygosity without K-ras mutation identified by molecular analysis on fine-needle aspiration cytology specimen of acinar cell carcinoma of pancreas.
Carcinoma, Adenoid Cystic
New Variations in the Promoter Regions of Human DOCK4 and RAP1A Genes, and Coding Regions of RAP1A in Sporadic Breast Tumors.
[Effect of shRNA-mediated silence of H-ras gene on proliferation of human SACC-M cells]
Carcinoma, Adenosquamous
Adenosquamous carcinoma of the pancreas: a clinicopathologic series of 25 cases.
Detection of K-ras mutations in lung carcinomas: relationship to prognosis.
Detection of low-fraction K-ras mutations in primary lung tumors using a sensitive method.
Mutations of epidermal growth factor receptor and K-ras genes in adenosquamous carcinoma of the lung.
Prognostic significance of K-ras codon 12 mutations in patients with resected stage I and II non-small-cell lung cancer.
The relationship between microvessel count and the expression of vascular endothelial growth factor, p53, and K-ras in non-small cell lung cancer.
Transition from squamous cell carcinoma to adenocarcinoma in adenosquamous carcinoma of the lung.
Trisomy 12 correlates with elevated expression of p21 ras in a human adenosquamous carcinoma of the lung.
Carcinoma, Basal Cell
Cdc42 is involved in basal cell carcinoma carcinogenesis.
H-ras-1 gene mutations in basal cell carcinoma: automated direct sequencing of clinical specimens.
HLA molecules in basal cell carcinoma of the skin.
Multiple stages in radiation carcinogenesis of rat skin.
Carcinoma, Bronchogenic
Lack of correlation between codon 12 K-ras mutations and major histocompatibility complex antigens in bronchogenic carcinomas.
Carcinoma, Ductal
?-Arrestin2 regulates lysophosphatidic acid-induced human breast tumor cell migration and invasion via Rap1 and IQGAP1.
Comparison of K-ras point mutations at codon 12 and p21 expression in pancreatic cancer between Japanese and Chinese patients.
Detection of K-ras gene mutations at codon 12 in the pancreatic juice of patients with intraductal papillary mucinous tumors of the pancreas.
Ductal and acinar differentiation in pancreatic endocrine tumors.
Genetic abnormalities in pancreatic cancer.
High Frequency of Codon 12 but not Codon 13 and 61 K-ras Gene Mutations in Invasive Ductal Carcinoma of Breast in a South Indian Population.
Loss of a c-H-ras-1 allele and aggressive human primary breast carcinomas.
Origin of giant cells in osteoclast-like giant cell tumors of the pancreas.
Pancreatic lymph nodal and plexus micrometastases detected by enriched polymerase chain reaction and nonradioisotopic single-strand conformation polymorphism analysis: a new predictive factor for recurrent pancreatic carcinoma.
The K-ras mutation pattern in pancreatic ductal adenocarcinoma usually is identical to that in associated normal, hyperplastic, and metaplastic ductal epithelium.
The role of p21ras in pancreatic neoplasia and chronic pancreatitis.
[Differential genetic pathway of duct and acinar carcinomas of the pancreas]
Carcinoma, Embryonal
A transfected H-ras oncogene does not inhibit differentiation of cardiac and skeletal muscle from embryonal carcinoma cells.
Cdc42-mTOR signaling pathway controls Hes5 and Pax6 expression in retinoic acid-dependent neural differentiation.
Cdo promotes neuronal differentiation via activation of the p38 mitogen-activated protein kinase pathway.
RhoB expression is induced after the transient upregulation of RhoA and Cdc42 during neuronal differentiation and influenced by culture substratum and microtubule integrity.
Carcinoma, Endometrioid
A dualistic model for endometrial carcinogenesis based on immunohistochemical and molecular genetic analyses.
Genetics of endometrial cancers.
Malignant transformation of endometriosis and genetic alterations of K-ras and microsatellite instability.
Molecular genetic pathways in various types of endometrial carcinoma: from a phenotypical to a molecular-based classification.
Molecular Pathology of Endometrial Carcinoma: Practical aspects from the diagnostic and therapeutical view points.
Molecular pathology of endometrial hyperplasia and carcinoma.
Molecular profile of grade 3 endometrioid endometrial carcinoma: is it a type I or type II endometrial carcinoma?
Novel ovarian endometriosis model causes infertility via iron-mediated oxidative stress in mice.
The Synergistic Effect of Conditional Pten Loss and Oncogenic K-ras Mutation on Endometrial Cancer Development Occurs via Decreased Progesterone Receptor Action.
[Dualistic model of molecular pathogenesis in endometrial carcinoma]
Carcinoma, Giant Cell
[Progress and prospect in basic and clinical lung cancer researches]
Carcinoma, Hepatocellular
A role for small GTPase RhoA in regulating intracellular membrane traffic of lysosomes in invasive rat hepatoma cells.
A role for the small GTPase Rab21 in the early endocytic pathway.
Activating mutations of the c-Ha-ras protooncogene in chemically induced hepatomas of the male B6C3 F1 mouse.
Activation of H-ras oncogenes in male B6C3F1 mouse liver tumors induced by vinthionine or 2-chloroethyl-methyl sulfide.
Akt phosphorylation of deleted in liver cancer 1 abrogates its suppression of liver cancer tumorigenesis and metastasis.
Alterations in metastatic properties of hepatocellular carcinoma cell following H-ras oncogene transfection.
Apoptosis of human BEL-7402 hepatocellular carcinoma cells released by antisense H-ras DNA--in vitro and in vivo studies.
Aspafilioside B induces G2/M cell cycle arrest and apoptosis by up-regulating H-Ras and N-Ras via ERK and p38 MAPK signaling pathways in human hepatoma HepG2 cells.
beta-catenin mutations are absent in hepatocellular carcinomas of SV40 T-antigen transgenic mice.
Beta-catenin mutations in liver tumors induced by 2-amino-3,4-dimethylimidazo[4,5-f]quinoline in CDF1 mice.
Blocking oncogenic Ras signaling for cancer therapy.
BRAF and PIK3CA genes are somatically mutated in hepatocellular carcinoma among patients from South Italy.
Carcinogen-induced liver tumours of Wistar rats: absence of activated ras genes and of N-rasC.
Cell proliferation and drug resistance in hepatocellular carcinoma are modulated by Rho GTPase signals.
Circular RNA MYLK promotes hepatocellular carcinoma progression by increasing Rab23 expression by sponging miR-362-3p.
Codon 64 of K-ras gene mutation pattern in hepatocellular carcinomas induced by bleomycin and 1-nitropyrene in A/J mice.
Decreased apoptosis in advanced-stage/high-grade hepatocellular carcinoma complicating chronic hepatitis C is mediated through the downregulation of p21 ras.
Depletion of Pokemon gene inhibits hepatocellular carcinoma cell growth through inhibition of H-ras.
Detection of hepatitis-B virus-DNA and mutations in k-ras and p53 genes in human hepatocellular carcinomas.
Detection of K-ras point mutations in the supernatants of peritoneal and pleural effusions for diagnosis complementary to cytologic examination.
Differential expression of Rab27A/B correlates with clinical outcome in hepatocellular carcinoma.
Donor polymorphisms of Rap1A rs494453 contribute to a higher risk of hepatocellular carcinoma recurrence following liver transplantation.
Downregulation of serum RAB27B confers improved prognosis and is associated with hepatocellular carcinoma progression through PI3K-AKT-P21 signaling.
Enhancement of migration and invasion of hepatoma cells via a Rho GTPase signaling pathway.
Erratum: miR-185 inhibits cell migration and invasion of hepatocellular carcinoma through CDC42.
Expression of H-ras and c-myc protooncogenes in isolated gamma-glutamyl transpeptidase-positive rat hepatocytes and in hepatocellular carcinomas induced by diethylnitrosamine.
Expression of oncogenes and tumor suppressor genes in human hepatocellular carcinoma and hepatoblastoma cell lines.
Expression of Organic Anion Transporting Polypeptides in an H-Ras 12V Transgenic Mouse Model of Spontaneous Hepatocellular Carcinoma.
Functional analysis of miR-101-3p and Rap1b involved in hepatitis B virus-related hepatocellular carcinoma pathogenesis.
Gd-EOB-DTPA Enhanced Micro-MR Imaging of Hepatic Tumors in H-ras 12V Transgenic Mice.
H-ras Consensus Sequence and Mutations in Primary Hepatocellular Carcinomas of Lemurs and Lorises.
Hepatitis B virus X protein up-regulates oncogene Rab18 to result in the dysregulation of lipogenesis and proliferation of hepatoma cells.
Hepatocarcinogenesis in mice with beta-catenin and Ha-ras gene mutations.
Hepatocyte expression of tumor associated aldehyde dehydrogenase (ALDH-3) and p21 Ras following diethylnitrosamine (DEN) initiation and chronic exposure to di(2-ethylhexyl)phthalate (DHEP).
High expression of Rap2A is associated with poor prognosis of patients with hepatocellular carcinoma.
Immunocytochemical localization of p21 ras gene product in human hepatoma cell lines and corresponding tumors in athymic mice.
Increased expression of c-jun gene during spontaneous hepatocarcinogenesis in LEC rats.
Infrequent point mutations in codons 12 and 61 of ras oncogenes in human hepatocellular carcinomas.
Inhibition of cell proliferation and metastasis of human hepatocellular carcinoma by miR-137 is regulated by CDC42.
Integrin ?9 Suppresses Hepatocellular Carcinoma Metastasis by Rho GTPase Signaling.
Involvement of mitophagy in oncogenic K-Ras-induced transformation: Overcoming a cellular energy deficit from glucose deficiency.
K-ras Gene Mutations in Liver Carcinomas from a Mediterranean Area of Spain.
Knockdown of mutated H-Ras V12 expression induces chemosensitivity of hepatocellular carcinoma cells to cisplatin treatment in vitro and in nude mouse xenografts.
Long non-coding RNA HOTAIR promotes exosome secretion by regulating RAB35 and SNAP23 in hepatocellular carcinoma.
Low frequency of H-ras activation in naturally occurring hepatocellular tumors of C3H/HeNCr mice.
MicroRNA-195 suppresses angiogenesis and metastasis of hepatocellular carcinoma by inhibiting the expression of VEGF, VAV2 and CDC42.
miR-145-5p Acts as a Novel Tumor Suppressor in Hepatocellular Carcinoma Through Targeting RAB18.
miR-185 inhibits cell migration and invasion of hepatocellular carcinoma through CDC42.
miR-455 Inhibits the Viability and Invasion by Targeting RAB18 in Hepatocellular Carcinoma.
Modulation of apoptosis, tumorigenesity and metastatic potential with antisense H-ras oligodeoxynucleotides in a high metastatic tumor model of hepatoma: LCI-D20.
Molecular Characteristics of Fibrolamellar Hepatocellular Carcinoma.
Mutational activation of H-ras and K-ras genes is absent in N-nitroso-N-methylurea-induced liver tumors in rats.
Mutational analysis of the p53 and K-ras genes and allelotype study of the Rb-1 gene for investigating the pathogenesis of combined hapatocellular-cholangiocellular carcinomas.
O-GlcNAcylation on Rab3A attenuates its effects on mitochondrial oxidative phosphorylation and metastasis in hepatocellular carcinoma.
Oncogene mediated repression of glucocorticoid hormone response elements and glucocorticoid receptor levels.
Peroxiredoxin I is important for cancer-cell survival in Ras-induced hepatic tumorigenesis.
Preferential loss of heterozygosity of chromosome 7 loci in simian virus 40 t/T antigen-induced mouse hepatocellular carcinomas does not involve H-ras mutations.
Prevalence of K-Ras mutations in hepatocellular carcinoma: A Turkish Oncology Group pilot study.
RAB18 promotes proliferation and metastasis in hepatocellular carcinoma.
Rab23 is a potential biological target for treating hepatocellular carcinoma.
Rab23 Promotes Hepatocellular Carcinoma Cell Migration Via Rac1/TGF-? Signaling.
Rab27B enhances drug resistance in hepatocellular carcinoma by promoting exosome-mediated drug efflux.
Rab5a promotes the migration and invasion of hepatocellular carcinoma by up-regulating Cdc42.
Rap1b enhances the invasion and migration of hepatocellular carcinoma cells by up-regulating Twist 1.
RAP2A promotes apoptosis resistance of hepatocellular carcinoma cells via the mTOR pathway.
Rho GTPases in hepatocellular carcinoma.
Study of the correlation between H-ras mutation and primary hepatocellular carcinoma.
Sublocalization of Rab23, a mediator of Sonic hedgehog signaling pathway, in hepatocellular carcinoma cell lines.
Supporting Role for GTPase Rab27a in Hepatitis C Virus RNA Replication through a Novel miR-122-Mediated Effect.
The formin INF2 regulates basolateral-to-apical transcytosis and lumen formation in association with Cdc42 and MAL2.
The Rho GTPase Rnd1 inhibits epithelial-mesenchymal transition in hepatocellular carcinoma and is a favorable anti-metastasis target.
Up-regulation of Rac GTPase activating protein 1 is significantly associated with the early recurrence of human hepatocellular carcinoma.
Upregulated expression of ROCK1 promotes cell proliferation by functioning as a target of miR-335-5p in non-small cell lung cancer.
Vps34 Inhibits Hepatocellular Carcinoma Invasion by Regulating Endosome-Lysosome Trafficking via Rab7-RILP and Rab11.
[A study on expression of various oncogenes and tumor-associated genes in LEC rats spontaneously developing hepatitis and hepatoma]
[Alterations in metastatic properties of hepatocellular carcinoma cell following H-ras oncogene transfection]
[Effect of Cdc42 gene inhibited on proliferation, migration and invasion in human hepatocellular carcinoma cells].
[Expression of H-ras gene in mouse 615 transplantable hepatoma]
[Influence of compensatory hepatocyte proliferation on the carcinogenesis of N-nitrosodimethylamine]
[Relationships between intrahepatic metastasis of hepatocellular carcinoma and in situ microenvironment, and the abundance of nm23-H1 H-ras mRNA]
[The effect of antisense H-ras on growth and metastasis of a high metastatic tumor model of human hepatoma in nude mice LCI-D20]
Carcinoma, Intraductal, Noninfiltrating
?-Arrestin2 regulates lysophosphatidic acid-induced human breast tumor cell migration and invasion via Rap1 and IQGAP1.
Different amounts of K-ras mutant epithelial cells in pancreatic carcinoma and mass-forming pancreatitis.
Intraductal papillary-mucinous tumours represent a distinct group of pancreatic neoplasms: an investigation of tumour cell differentiation and K-ras, p53 and c-erbB-2 abnormalities in 26 patients.
K-ras gene mutation in early ductal lesions induced in a rapid production model for pancreatic carcinomas in Syrian hamsters.
Molecular characterization of intraductal breast carcinomas.
Carcinoma, Islet Cell
Nonfunctioning islet cell carcinoma of the pancreas with high serum CEA & CA19-9, K-ras codon 12 mutation, and microsatellite instability.
Carcinoma, Large Cell
K-ras and rho A mutations in malignant pleural effusion.
K-ras mutation in sputum of primary lung cancer patients does not always reflect that of cancerous cells.
The relationship between microvessel count and the expression of vascular endothelial growth factor, p53, and K-ras in non-small cell lung cancer.
Validation of the Point-EXACCT method in non-small cell lung carcinomas.
Carcinoma, Lewis Lung
Inhibition of CDC42 reduces macrophage recruitment and suppresses lung tumorigenesis in vivo.
Carcinoma, Medullary
Point mutations of ras and Gs alpha subunit genes in thyroid tumors.
Carcinoma, Mucoepidermoid
Genetic alteration in carcinoid tumors of the lung.
H-ras gene mutations in salivary gland mucoepidermoid carcinomas.
Mucoepidermoid carcinoma of the lung, response to EGFR inhibitors, EGFR and K-RAS mutations, and differential diagnosis.
ras gene mutations in salivary gland tumors.
Carcinoma, Neuroendocrine
Analysis of K-ras, N-ras, H-ras, and p53 in lung neuroendocrine neoplasms.
K-ras point mutations in the supernatants of pancreatic juice and bile are reliable for diagnosis of pancreas and biliary tract carcinomas complementary to cytologic examination.
Carcinoma, Non-Small-Cell Lung
A fast and convenient new technique to detect the therapeutic target, K-ras mutant, from peripheral blood in non-small cell lung cancer patients.
A synthetic lethal interaction between K-Ras oncogenes and Cdk4 unveils a therapeutic strategy for non-small cell lung carcinoma.
Abnormal expression of p120-catenin, E-cadherin, and small GTPases is significantly associated with malignant phenotype of human lung cancer.
Aerosol delivery of lentivirus-mediated O-glycosylation mutant osteopontin suppresses lung tumorigenesis in K-ras (LA1) mice.
Akt/protein kinase B is constitutively active in non-small cell lung cancer cells and promotes cellular survival and resistance to chemotherapy and radiation.
Allele-specific detection of K-ras oncogene expression in human non-small-cell lung carcinomas.
An overview of farnesyltransferase inhibitors and their role in lung cancer therapy.
Analysis of K-ras, p53, bcl-2 and Rb expression in non-small cell lung cancer cell lines.
Assessment of EGFR and K-ras mutations in fixed and fresh specimens from transesophageal ultrasound-guided fine needle aspiration in non-small cell lung cancer patients.
Assessment of epidermal growth factor receptor and K-ras mutation status in cytological stained smears of non-small cell lung cancer patients: correlation with clinical outcomes.
Association of epidermal growth factor receptor and K-Ras mutations with smoking history in non-small cell lung cancer patients.
Association of K-ras codon 12 transversions with short survival in non-small cell lung cancer.
Automated real-time PCR to determine K-ras codon 12 mutations in non-small cell lung cancer: comparison with immunohistochemistry and clinico-pathological features.
Avicin G is a potent sphingomyelinase inhibitor and blocks oncogenic K- and H-Ras signaling.
c-Raf, but not B-Raf, is essential for development of K-Ras oncogene-driven non-small cell lung carcinoma.
Cellular protoonocogenes are infrequently amplified in untreated non-small cell lung cancer.
Clinical outcome of patients with non-small cell lung cancer receiving front-line chemotherapy according to EGFR and K-RAS mutation status.
Clinical significance and the correlation of expression between Let-7 and K-ras in non-small cell lung cancer.
Combination therapy targeting BCL6 and phospho-STAT3 defeats intra-tumor heterogeneity in a subset of non-small cell lung cancers.
Comparison of oncogene mutation detection and telomerase activity for the molecular staging of non-small cell lung cancer.
Conditional mouse lung cancer models using adenoviral or lentiviral delivery of Cre recombinase.
Correlation of immunohistochemical staining p63 and TTF-1 with EGFR and K-ras mutational spectrum and diagnostic reproducibility in non small cell lung carcinoma.
CpG island promoter hypermethylation of the Ras-effector gene NORE1A occurs in the context of a wild-type K-ras in lung cancer.
CT Radiogenomic Characterization of EGFR, K-RAS, and ALK Mutations in Non-Small Cell Lung Cancer.
Deletion of cyclooxygenase-2 inhibits K-ras-induced lung carcinogenesis.
DEPENDENCE ON THE MUC1-C ONCOPROTEIN IN NON-SMALL CELL LUNG CANCER CELLS WITH EGFR AND K-RAS MUTATIONS.
Design, synthesis, and biological evaluation of novel substituted thiourea derivatives as potential anticancer agents for NSCLC by blocking K-Ras protein-effectors interactions.
Detection by denaturant gradient gel electrophoresis of tumor-specific mutations in biopsies and relative bronchoalveolar lavage fluid from resectable non-small cell lung cancer.
Detection of activated K-ras in non-small cell lung cancer by membrane array: a comparison with direct sequencing.
Detection of K-ras and p53 mutations in bronchoscopically obtained malignant and non-malignant tissue from patients with non-small cell lung cancer.
Detection of K-ras gene mutations in non-neoplastic lung tissue and lung cancers.
Detection of K-Ras mutations in tumour samples of patients with non-small cell lung cancer using PNA-mediated PCR clamping.
Downregulation of miR-25 modulates non-small cell lung cancer cells by targeting CDC42.
Downregulation of RECK by promoter methylation correlates with lymph node metastasis in non-small cell lung cancer.
Dr. Neri et al.: Prognostic role of K-ras mutations in non-small cell lung cancer: Still an issue for open debate.
Dual phosphoinositide 3-kinase/mammalian target of rapamycin blockade is an effective radiosensitizing strategy for the treatment of non-small cell lung cancer harboring K-RAS mutations.
Dual targeting of PI3K and MEK enhances the radiation response of K-RAS mutated non-small cell lung cancer.
Effects of silencing Rab27a gene on biological characteristics and chemosensitivity of non-small cell lung cancer.
Efficacy of PHA-848125, a cyclin-dependent kinase inhibitor, on the K-Ras(G12D)LA2 lung adenocarcinoma transgenic mouse model: evaluation by multimodality imaging.
EGFR and K-ras mutation analysis in non-small cell lung cancer: comparison of paraffin embedded versus frozen specimens.
EGFR and K-RAS mutations and ERCC1, TUBB3, TYMS, RRM1 and EGFR mRNA expression in non-small cell lung cancer: Correlation with clinical response to gefitinib or chemotherapy.
EGFR autophosphorylation but not protein score correlates with histologic and molecular subtypes in lung adenocarcinoma.
Enhancing therapeutic efficacy of the MEK inhibitor, MEK162, by blocking autophagy or inhibiting PI3K/Akt signaling in human lung cancer cells.
Epidermal Growth Factor Receptor Signaling in Nonsmall Cell Lung Cancer.
ERK2-dependent reactivation of Akt mediates the limited response of tumor cells with constitutive K-RAS activity to PI3K inhibition.
Expression of the receptor tyrosine kinase EphA2 is increased in smokers and predicts poor survival in non-small cell lung cancer.
FHIT and p53 gene abnormalities in bronchioloalveolar carcinomas. Correlations with clinicopathological data and K-ras mutations.
Frequent polymorphic variations but rare tumour specific mutations of the S100A2 on 1q21 in non-small cell lung cancer.
Genetic analysis of the catalytic domain of the GAP gene in human lung cancer cell lines.
Genomics of non-small cell lung cancer (NSCLC): Association between CT-based imaging features and EGFR and K-RAS mutations in 122 patients-An external validation.
Glucose-6-Phosphate Dehydrogenase Is Not Essential for K-Ras-Driven Tumor Growth or Metastasis.
Growth inhibition of non-small-cell lung carcinoma by BN/GRP antagonist is linked with suppression of K-Ras, COX-2, and pAkt.
GSTM1, P53 and K-ras molecular detection in resectable non-small cell lung cancer by denaturing gradient gel electrophoresis-bronchoalveolar lavage fluid analysis.
Hyperglycemia promotes K-Ras-induced lung tumorigenesis through BASCs amplification.
Hypomethylation of CCGG sites in the 3' region of H-ras protooncogene is frequent and is associated with H-ras allele loss in non-small cell lung cancer.
Identification of a new inhibitor of KRAS-PDE? interaction targeting KRAS mutant non-small cell lung cancer.
Identification of secreted proteins that mediate cell-cell interactions in an in vitro model of the lung cancer microenvironment.
In Silico Screening of Mutated K-Ras Inhibitors from Malaysian Typhonium flagelliforme for Non-Small Cell Lung Cancer.
In vitro study of farnesyltransferase inhibitor SCH 66336, in combination with chemotherapy and radiation, in non-small cell lung cancer cell lines.
Incidence and possible clinical significance of K-ras oncogene activation in adenocarcinoma of the human lung.
Increased epidermal growth factor receptor (EGFR) gene copy number is strongly associated with EGFR mutations and adenocarcinoma in non-small cell lung cancers: a chromogenic in situ hybridization study of 182 patients.
Inhibition of AKT1 signaling promotes invasion and metastasis of non-small cell lung cancer cells with K-RAS or EGFR mutations.
Inhibition of lung cancer growth: ATP citrate lyase knockdown and statin treatment leads to dual blockade of mitogen-actiated protein kinase (MAPK) and phosphatidylinositol-3- kinase (PI3K)/AKT pathways.
Interferon-? reduces the gefitinib sensitivity of human non-small cell lung cancer.
K-ras activation in non-small cell lung cancer in the dog.
K-ras as a target for lung cancer therapy.
K-ras codon 12 mutations detected with enriched PCR method in operable non-small cell lung cancer.
K-ras gene mutations in non-small cell lung cancer in Japanese.
K-ras gene point mutation: a stable tumor marker in non-small cell lung carcinoma.
k-RAS mutation and resistance to epidermal growth factor receptor-tyrosine kinase inhibitor treatment in patients with nonsmall cell lung cancer.
K-ras mutations in 239PuO2 canine lung neoplasms.
k-RAS mutations in non-small cell lung cancer patients treated with TKIs among smokers and non-smokers: a meta-analysis.
K-ras mutations in non-small-cell lung carcinoma: a review.
K-ras oncogene mutation as a prognostic marker in non-small cell lung cancer: a combined analysis of 881 cases.
LATS2 tumour specific mutations and down-regulation of the gene in non-small cell carcinoma.
Long noncoding RNA RHPN1-AS1 promotes colorectal cancer progression via targeting miR-7-5p/OGT axis.
Lovastatin overcomes gefitinib resistance in human non-small cell lung cancer cells with K-Ras mutations.
Low frequency of p53 and k-ras codon 12 mutations in non-small cell lung carcinoma (NSCLC) tumors and surgical margins.
MicroRNA let-7a Inhibits the Proliferation and Invasion of Nonsmall Cell Lung Cancer Cell Line 95D by Regulating K-Ras and HMGA2 Gene Expression.
MicroRNA-29a functions as a potential tumor suppressor through directly targeting CDC42 in non-small cell lung cancer.
MicroRNA-30b/c inhibits non-small cell lung cancer cell proliferation by targeting Rab18.
MiR-135a inhibits non-small cell lung cancer progression by suppressing RAB1B expression and the RAS pathway.
MiR-185-5p targets RAB35 gene to regulate tumor cell-derived exosomes-mediated proliferation, migration and invasion of non-small cell lung cancer cells.
MiR-501-3p functions as a tumor suppressor in non-small cell lung cancer by downregulating RAP1A.
Modification of mutant K-ras gene expression in non-small cell lung cancer (NSCLC).
Molecular assessment of lymph nodes in patients with resected stage I non-small cell lung cancer: preliminary results of a prospective study.
Molecular genetics of small cell lung carcinoma.
Molecular staging of non-small cell lung cancer according to K-ras genotypes.
Mouse model for lung tumorigenesis through Cre/lox controlled sporadic activation of the K-Ras oncogene.
Mutated K-ras gene analysis in a randomized trial of preoperative chemotherapy plus surgery versus surgery in stage IIIA non-small cell lung cancer.
Mutations in K-ras codon 12 detected in plasma DNA are not an indicator of disease in patients with non-small cell lung cancer.
Mutations of p53 and K-ras genes as prognostic factors for non-small cell lung cancer.
No occurrence of DNA-polymerase Beta-gene mutation in human lung-carcinoma cell-lines with k-ras as, p53, or rb gene alterations.
Oncogenic Activity of Ect2 Is Regulated through Protein Kinase C{iota}-mediated Phosphorylation.
Optimization of patient selection for gefitinib in non-small cell lung cancer by combined analysis of epidermal growth factor receptor mutation, K-ras mutation, and Akt phosphorylation.
Overexpression of small GTPases directly correlates with expression of ?-catenin and their coexpression predicts a poor clinical outcome in nonsmall cell lung cancer.
p120-catenin is transcriptionally downregulated by FOXC2 in non-small cell lung cancer cells.
Partial suppression of tumorigenicity in a human lung cancer cell line transfected with Krev-1.
Phenotype of bone metastases of non-small cell lung cancer: epidermal growth factor receptor expression and K-RAS mutational status.
PKC? regulates integrin ?V?3 expression and transformed growth of K-ras dependent lung cancer cells.
Predictive and prognostic biomarkers with therapeutic targets in breast, colorectal, and non-small cell lung cancers: A systemic review of current development, evidence, and recommendation.
Predictive value of K-ras and PIK3CA in non-small cell lung cancer patients treated with EGFR-TKIs: a systemic review and meta-analysis.
Prognostic and predictive value of K-RAS mutations in non-small cell lung cancer.
Prognostic impact of mutated K-ras gene in surgically resected non-small cell lung cancer patients.
Prognostic role of K-Ras mutations in non-small cell lung cancer: still an issue for open debate.
Prognostic role of Rab27A and Rab27B expression in patients with non-small cell lung carcinoma.
Prognostic value of genetically diagnosed lymph node micrometastasis in non-small cell lung carcinoma cases.
Prognostic value of k-ras 12 genotypes in patients with advanced nonsmall cell lung-cancer receiving Carboplatin with either intravenous or chronic oral dose Etoposide.
Prognostic value of K-RAS mutations in patients with non-small cell lung cancer: a systematic review with meta-analysis.
Protein Kinase C {delta} Is a Downstream Effector of Oncogenic K-ras in Lung Tumors.
Quantification of Tumor Burden in a Genetically Engineered Mouse Model of Lung Cancer by Micro-CT and Automated Analysis.
RAB38 is a potential prognostic factor for tumor recurrence in non-small cell lung cancer.
Ras mutational status is a biomarker for resistance to EGFR inhibitors in colorectal carcinoma.
Relationship of Ras association domain family 1 methylation and K-ras mutation in primary non-small cell lung cancer.
Restoration of mutant K-Ras repressed miR-199b inhibits K-Ras mutant non-small cell lung cancer progression.
Role of epidermal growth factor receptor overexpression, K-ras point mutation and c-myc amplification in the carcinogenesis of non-small cell lung cancer.
Single-agent paclitaxel by 3-hour infusion in the treatment of non-small cell lung cancer: links between p53 and K-ras gene status and chemosensitivity.
Sirt1 protects from K-Ras-driven lung carcinogenesis.
SmgGDS regulates cell proliferation, migration, and NF-kappaB transcriptional activity in non-small cell lung carcinoma.
Sorafenib in patients with advanced non-small cell lung cancer that harbor K-ras mutations: a brief report.
Sotorasib: First Approval.
Synergistic effects of sorafenib in combination with gemcitabine or pemetrexed in lung cancer cell lines with K-ras mutations.
TBK1 kinase addiction in lung cancer cells is mediated via autophagy of Tax1bp1/Ndp52 and non-canonical NF-?B signalling.
The K-ras gene regulates vascular endothelial growth factor gene expression in non-small cell lung cancers.
The presence of Merkel cell polyomavirus is associated with deregulated expression of BRAF and Bcl-2 genes in non-small cell lung cancer.
The Ras inhibitor farnesylthiosalicylic acid (Salirasib) disrupts the spatiotemporal localization of active Ras: a potential treatment for cancer.
The relationship between microvessel count and the expression of vascular endothelial growth factor, p53, and K-ras in non-small cell lung cancer.
The small GTPase RhoA has greater expression in small cell lung carcinoma than in non-small cell lung carcinoma and contributes to their unique morphologies.
Tissue factor expression in non-small cell lung cancer: relationship with vascular endothelial growth factor expression, microvascular density, and K-ras mutation.
Vascular endothelial growth factor and other biological predictors related to the postoperative survival rate on non-small cell lung cancer.
[Correlation of expression of p120ctn , RhoA and Cdc42 and their significance in non-small cell lung cancer.]
[Detection of EGFR and K-ras mutations in non-small cell lung cancer using cytological specimens].
[Detection of mutations of the K-ras gene in condensed breath of patients with non-small-cell lung carcinoma (NSCLC) as a possible noninvasive screening method]
[Enhanced growth inhibition by combined two pathway inhibitors on K-ras mutated non-small cell lung cancer cells].
[Expression and clinical significance of caspase-3,survivin and k-ras in non-small cell lung cancer.]
[K-RAS gene mutations in patients with non-small cell lung cancer]
[K-ras mutation predictive significance in platinum based chemotherapeutic protocols in patients with advanced non-small cell lung cancer]
[Mutational analysis of EGFR and K-RAS in Chinese patients with non-small cell lung cancer]
[Relationship between EGFR and K-ras mutations and clinicopathological characteristics and response to erlotinib treatment in 301 Chinese patients with non-small cell lung cancer].
[Relationship between the protein expression of ERCC1, BRCA, ?-tubulin and K-ras and the efficacy and prognosis in advanced non-small cell lung cancer].
[Study on point mutations of K-ras gene in non-small cell lung cancer in Guangxi].
[The Expression of COX-2 in Human Lung Cancer and its Relationship with Expression of K-ras and Mcl-1.]
Carcinoma, Ovarian Epithelial
An essential role for Ran GTPase in epithelial ovarian cancer cell survival.
Cyclooxygenase-1 is overexpressed in multiple genetically engineered mouse models of epithelial ovarian cancer.
Glucocorticoids mediate induction of microRNA-708 to suppress ovarian cancer metastasis through targeting Rap1B.
Pathogenesis of ovarian cancers.
Rac GTPase activating protein 1 promotes oncogenic progression of epithelial ovarian cancer.
Rac1 expression in epithelial ovarian cancer: effect on cell EMT and clinical outcome.
ras gene activation and infrequent mutation in papillary serous carcinoma of the peritoneum.
Carcinoma, Pancreatic Ductal
Detection of K-ras gene mutations at codon 12 in the pancreatic juice of patients with intraductal papillary mucinous tumors of the pancreas.
Detection of point mutations in the K-ras oncogene at codon 12 in pure pancreatic juice for diagnosis of pancreatic carcinoma.
Determination of pancreatic ductal carcinoma histogenesis by analysis of mucous quality and K-ras mutation.
Genetic profile of 22 pancreatic carcinoma cell lines. Analysis of K-ras, p53, p16 and DPC4/Smad4.
Guanine Nucleotide Exchange Factors for RhoGTPases: Good Therapeutic Targets for Cancer Therapy?
In vitro modeling of human pancreatic duct epithelial cell transformation defines gene expression changes induced by K-ras oncogenic activation in pancreatic carcinogenesis.
Intercalated duct cell is starting point in development of pancreatic ductal carcinoma?
K-ras mutation and p53 protein accumulation in intraductal mucin-hypersecreting neoplasms of the pancreas.
K-ras mutations and allelic loss at 5q and 18q in the development of human pancreatic cancers.
Multiple K-ras mutations in hyperplasia and carcinoma in cases of human pancreatic carcinoma.
p53 protein overexpression and K-ras codon 12 mutation in pancreatic ductal carcinoma: correlation with histologic factors.
Selective killing of K-ras-transformed pancreatic cancer cells by targeting NAD(P)H oxidase.
The K-ras mutation pattern in pancreatic ductal adenocarcinoma usually is identical to that in associated normal, hyperplastic, and metaplastic ductal epithelium.
Carcinoma, Papillary
Can Different Thyroid Tumor Types Be Distinguished by Polymerase Chain Reaction-Based K-ras Mutation Detection?
H-ras protooncogene mutations in human thyroid neoplasms.
Low frequency of TERT promoter mutations in a series of well-differentiated follicular-patterned thyroid neoplasms.
p53 gene mutation and p53 protein overexpression in a patient with simultaneous double cancer of the gallbladder and bile duct associated with pancreaticobiliary maljunction.
Point mutations of ras and Gs alpha subunit genes in thyroid tumors.
Prevalences of Gs alpha, ras, p53 mutations and ret/PTC rearrangement in differentiated thyroid tumours in a Korean population.
[Thyroid carcinoma]
[Value of the expression of p21RAS, P53, Bcl-2 oncoproteins and Ki-67(MIB-1) antigen of cellular proliferation in the diagnosis and prognosis of thyroi]
Carcinoma, Renal Cell
Activated H-ras oncogenes in human kidney tumors.
Activation of the mTOR signaling pathway in renal clear cell carcinoma.
Author Correction: Rap2a serves as a potential prognostic indicator of renal cell carcinoma and promotes its migration and invasion through up-regulating p-Akt.
Chemotherapy for advanced adrenal cancer: improvement from a molecular approach?
Evidence for aldosterone-dependent growth of renal cell carcinoma.
Gene expression and protein array studies of folliculin-regulated pathways.
Genetic instability in renal cell carcinoma.
HIF-1alpha mRNA and protein upregulation involves Rho GTPase expression during hypoxia in renal cell carcinoma.
Higher expression of K-ras is associated with parathyroid hormone-related protein-induced hypercalcaemia in renal cell carcinoma.
Hypoxia up-regulates hypoxia-inducible factor-1alpha expression through RhoA activation in trophoblast cells.
miR-28-5p acts as a tumor suppressor in renal cell carcinoma for multiple antitumor effects by targeting RAP1B.
miR-384 suppressed renal cell carcinoma cell proliferation and migration through targeting RAB23.
Oncogenic effects of RAB27B through exosome independent function in renal cell carcinoma including sunitinib-resistant.
Pathology and proliferative activity of renal-cell carcinomas (RCCS) and renal oncocytomas in patients with different radiation exposure after the Chernobyl accident in Ukraine.
Proliferative heterogeneity of human renal cell carcinomas and prevalence of ras gene point mutations.
RAB27A is an independent prognostic factor in clear cell renal cell carcinoma.
Rap2a serves as a potential prognostic indicator of renal cell carcinoma and promotes its migration and invasion through up-regulating p-Akt.
Splicing variant of Cdc42 interacting protein-4 disrupts beta-catenin-mediated cell-cell adhesion: expression and function in renal cell carcinoma.
Synthetic miR-143 Exhibited an Anti-Cancer Effect via the Downregulation of K-RAS Networks of Renal Cell Cancer Cells In Vitro and In Vivo.
Carcinoma, Signet Ring Cell
Phenotypic classification of gastric signet ring cell carcinoma and its relationship with K-ras mutation.
Carcinoma, Small Cell
Detection of activating mutations in the ras family genes in cytological specimens from lung-tumors.
Immunohistochemical and genetic analysis of non-small cell and small cell gallbladder carcinoma and their precursor lesions.
Ovarian small cell carcinoma with K-ras mutation: a case report with genetic analysis.
Small cell carcinoma of the gallbladder: a clinicopathologic, immunohistochemical, and molecular pathology study of 12 cases.
[Detection of K-ras mutation from malignant cells in sputum with mutant-allele specific amplification (MASA) method]
[Detection of K-ras oncogene activation in human lung cancer and its possible clinical application]
Carcinoma, Squamous Cell
"Low-risk" and "high-risk" HPV-infection and K-ras gene point mutations in human cervical cancer: a study of 31 cases.
A transforming Kirsten ras oncogene in an oral squamous carcinoma.
A universal method for the mutational analysis of K-ras and p53 gene in non-small-cell lung cancer using formalin-fixed paraffin-embedded tissue.
Acute sensitivity of the oral mucosa to oncogenic K-ras.
Age-associated inflammation connects RAS-induced senescence to stem cell dysfunction and epidermal malignancy.
Amplification of wild-type K-ras promotes growth of head and neck squamous cell carcinoma.
An immortalization-dependent switch in integrin function up-regulates MMP-9 to enhance tumor cell invasion.
Analysis of p53 tumor suppressor gene, H-ras protooncogene and proliferating cell nuclear antigen (PCNA) in squamous cell carcinomas of HRA/Skh mice following exposure to 8-methoxypsoralen (8-MOP) and UVA radiation (PUVA therapy).
Analysis of the K-ras and p53 pathways in X-ray-induced lung tumors in the rat.
Anti-EGFR therapeutic efficacy correlates directly with inhibition of STAT3 activity.
CCL19-induced chemokine receptor 7 activates the phosphoinositide-3 kinase-mediated invasive pathway through Cdc42 in metastatic squamous cell carcinoma of the head and neck.
CCR7 regulates cell migration and invasion through MAPKs in metastatic squamous cell carcinoma of head and neck.
Circulating miR-16-5p, miR-92a-3p, and miR-451a in Plasma from Lung Cancer Patients: Potential Application in Early Detection and a Regulatory Role in Tumorigenesis Pathways.
Clinicopathological pattern and Annexin A2 and Cdc42 status in patients presenting with differentiation and lymphnode metastasis of esophageal squamous cell carcinomas.
Cloning and sequencing of CATR1.3, a human gene associated with tumorigenic conversion.
Constitutively active Harvey Ras confers resistance to epidermal growth factor receptor-targeted therapy with cetuximab and gefitinib.
Deletion of epidermal Rac1 inhibits HPV-8 induced skin papilloma formation and facilitates HPV-8- and UV-light induced skin carcinogenesis.
Detection of activated K-ras in non-small cell lung cancer by membrane array: a comparison with direct sequencing.
Detection of K-ras mutations in lung carcinomas: relationship to prognosis.
Detection of K-ras oncogene mutations in bronchoalveolar lavage fluid for lung cancer diagnosis.
Detection of low-fraction K-ras mutations in primary lung tumors using a sensitive method.
Distribution of p53 and K-ras mutations in human lung cancer tissues.
Down-regulation of the Rho GTPase signaling pathway is involved in the microRNA-138 mediated inhibition of cell migration and invasion in tongue squamous cell carcinoma.
Effect of blocking Ras signaling pathway with K-Ras siRNA on apoptosis in esophageal squamous carcinoma cells.
Enforced C-Src Activation Causes Compartmental Dysregulation of PI3K and PTEN Molecules in Lipid Rafts of Tongue Squamous Carcinoma Cells by Attenuating Rac1-Akt-GLUT-1-Mediated Sphingolipid Synthesis.
Epidermal growth factor receptor and K-Ras mutations and resistance of lung cancer to insulin-like growth factor 1 receptor tyrosine kinase inhibitors.
Epidermal growth factor receptor and K-RAS status in two cohorts of squamous cell carcinomas.
ERBB2 kinase domain mutation in the lung squamous cell carcinoma.
ERK2-dependent reactivation of Akt mediates the limited response of tumor cells with constitutive K-RAS activity to PI3K inhibition.
Expression and mutation analysis of epidermal growth factor receptor in head and neck squamous cell carcinoma.
Expression of CDC42 in cervical squamous cell carcinoma and its correlation with clinicopathologic characteristics.
Genetic alterations in p53 and k-ras in lung-cancer in relation to histopathology of the tumor and smoking history of the patient.
Glutathione S-transferase mu1 null genotype is associated with K-ras gene mutation in lung adenocarcinoma among smokers.
GSTM1, P53 and K-ras molecular detection in resectable non-small cell lung cancer by denaturing gradient gel electrophoresis-bronchoalveolar lavage fluid analysis.
H-Ras activation and fibroblast-induced TGF-? signaling promote laminin-332 accumulation and invasion in cutaneous squamous cell carcinoma.
H-ras and Nm23-H1 gene expression and proteolytic activity in squamous cell carcinoma of the uterine cervix.
High frequency of ras mutations in forestomach and lung tumors of B6C3F1 mice exposed to 1-amino-2,4-dibromoanthraquinone for 2 years.
High incidence of H-ras oncogene mutations in squamous cell carcinoma of lip vermilion.
Immunohistochemical detection of the H-ras, K-ras, and N-ras oncogenes in squamous cell carcinoma of the head and neck.
Increased incidence of squamous cell carcinomas in Mastomys natalensis papillomavirus E6 transgenic mice during two-stage skin carcinogenesis.
Induction of invasive squamous cell carcinomas in the forestomach of (C3H x MSM)F1, MSM, and C3H mice by N-methyl-N-nitrosourea and mutational analysis of the H-ras and p53 genes.
Inhibition of Calcineurin/NFAT Signaling Blocks Oncogenic H-Ras Induced Autophagy in Primary Human Keratinocytes.
K-ras and rho A mutations in malignant pleural effusion.
K-ras gene point mutation: a stable tumor marker in non-small cell lung carcinoma.
K-ras mutation in sputum of primary lung cancer patients does not always reflect that of cancerous cells.
K-ras Mutation, HPV Infection and Smoking or Alcohol Abuse Positively Correlate with Esophageal Squamous Carcinoma.
K-ras mutations are frequent in pulmonary squamous cell carcinomas but not in adenocarcinomas of WBN/Kob rats induced by N-nitrosobis(2-oxopropyl)amine.
K-ras mutations in sinonasal cancers in relation to wood dust exposure.
Late occurrence of K-ras gene mutations in the pathogenesis of squamous cell carcinoma of the lung: analysis in sputum.
Low incidence of point mutation at codon 12 of K-ras proto-oncogene in squamous cell carcinoma of the upper aerodigestive tract.
Low levels of ras p21 oncogene expression correlates with clinical outcome in head and neck squamous cell carcinoma.
Low mutational rate of K-ras codon 12 in singular bronchoscopy specimens in suspected lung cancer.
Mechanism of H-ras oncogene activation in mouse squamous carcinoma induced by an alkylating agent.
Metastasis is driven by sequential elevation of H-ras and Smad2 levels.
Molecular analysis of p53 and K-ras in lung carcinomas of coal miners.
Multiple stages in radiation carcinogenesis of rat skin.
Murine squamous cell carcinoma cell lines produced by a complete carcinogenesis protocol with benzo[a]pyrene exhibit characteristic p53 mutations and the absence of H-ras and cyl 1/cyclin D1 abnormalities.
Mutated K-ras gene analysis in a randomized trial of preoperative chemotherapy plus surgery versus surgery in stage IIIA non-small cell lung cancer.
Mutational analysis of K-ras and Ras protein expression in larynx squamous cell carcinoma.
Mutations of K-ras oncogene and absence of H-ras mutations in squamous cell carcinomas of the lung.
Mutations, expression and genomic instability of the H-ras proto-oncogene in squamous cell carcinomas of the head and neck.
Oncogene amplification in squamous cell carcinoma of the head and neck.
Oncogene amplification in squamous cell carcinoma of the oral cavity.
Oncogene involvement in tumor regression: H-ras activation in the rabbit keratoacanthoma model.
Oncogenes in head and neck cancer.
Overlapping functions of Ras and Rac GTPases in regulating cancer cell proliferation and invasion.
pERK activation in esophageal carcinomas: clinicopathological associations.
Prevalence of K-ras Codon 12 Mutations in Indian Patients with Head and Neck Cancer.
Prevalence of K-RAS Codons 12 and 13 Mutations in Locally Advanced Head and Neck Squamous Cell Carcinoma and Impact on Clinical Outcomes.
Prognostic impact of mutated K-ras gene in surgically resected non-small cell lung cancer patients.
Prognostic role of Rab27A and Rab27B expression in patients with non-small cell lung carcinoma.
Prognostic significance of K-ras codon 12 mutations in patients with resected stage I and II non-small-cell lung cancer.
Prognostic significance of K-ras, p53, bcl-2, PCNA, CD34 in radically resected non-small cell lung cancers.
Progression of squamous carcinoma cells to spindle carcinomas of mouse skin is associated with an imbalance of H-ras alleles on chromosome 7.
Rab18 Regulates Proliferation, Invasion and Cisplatin Sensitivity Through STAT3 Signaling in Head and Neck Squamous Cell Carcinoma.
Rab23 promotes squamous cell carcinoma cell migration and invasion via integrin ?1/Rac1 pathway.
Rap1A and rap1B ras-family proteins are prominently expressed in the nucleus of squamous carcinomas: nuclear translocation of GTP-bound active form.
Rare occurrence of ras and p53 gene mutations in mouse stomach tumors induced by N-methyl-N-nitrosourea.
ras activation in human tumors and in animal model systems.
Ras gene mutation is not related to tumour invasion during rat tongue carcinogenesis induced by 4-nitroquinoline 1-oxide.
ras mutations and expression in head and neck squamous cell carcinomas.
Risk for K-ras gene mutations in smoking-induced lung cancer is associated with cytochrome P4501A1 and glutathione S-transferase micro1 polymorphisms.
Small GTPase RhoE/Rnd3 Is a Critical Regulator of Notch1 Signaling.
Somatic alterations of the serine/threonine kinase LKB1 gene in squamous cell (SCC) and large cell (LCC) lung carcinoma.
Synergistic effects of sorafenib in combination with gemcitabine or pemetrexed in lung cancer cell lines with K-ras mutations.
The identification and characterization of a GDP-dissociation inhibitor (GDI) for the CDC42Hs protein.
The radiosensitivity of human keratinocytes: influence of activated c-H-ras oncogene expression and tumorigenicity.
The relationship between microvessel count and the expression of vascular endothelial growth factor, p53, and K-ras in non-small cell lung cancer.
Validation of the Point-EXACCT method in non-small cell lung carcinomas.
Vascular endothelial growth factor and nitric oxide synthase expression in human lung cancer and the relation to p53.
[Detection of K-ras mutation from malignant cells in sputum with mutant-allele specific amplification (MASA) method]
[Detection of K-ras oncogene activation in human lung cancer and its possible clinical application]
Carcinoma, Transitional Cell
Activated H-ras gene mutations in transitional cell carcinoma of urinary bladder in a Kashmiri population.
Activated H-ras oncogenes in human kidney tumors.
Activation of H-ras oncogene in rat bladder tumors induced by N-butyl-N-(4-hydroxybutyl)nitrosamine.
Activation of RAS family genes in urothelial carcinoma.
Detection of H-ras gene point mutations in transitional cell carcinoma of human urinary bladder using polymerase chain reaction.
Frequency of H-ras mutations in human bladder cancer detected by direct sequencing.
Genetic aberrations of the K-ras proto-oncogene in bladder cancer in Kashmiri population.
K-RAS mutation in transitional cell carcinoma of urinary bladder.
p53 mutations in transitional cell carcinomas of the urinary bladder in rats treated with N-butyl-N-(4-hydroxybutyl)-nitrosamine.
Ras involvement in cells transformed with 2-amino-4-(5-nitro-2-furyl)thiazole (ANFT) in vitro and with N-[4-(5-nitro-2-furyl)-2-thiazoyl]formamide in vivo.
Vascular endothelial growth factor, p53, and the H-ras oncogene in Egyptian patients with bladder cancer.
Carcinoma, Verrucous
H-ras oncogene mutation and human papillomavirus infection in oral carcinomas.
Carcinosarcoma
A position 12-activated H-ras oncogene in all HS578T mammary carcinosarcoma cells but not normal mammary cells of the same patient.
Immunohistochemistry and K-ras sequence of pancreatic carcinosarcoma.
K-ras exon 2 point mutations in human endometrial cancer.
Molecular evidence that most but not all carcinosarcomas of the uterus are combination tumors.
p53 and K-ras mutational genotyping in pulmonary carcinosarcoma, spindle cell carcinoma, and pulmonary blastoma: implications for histogenesis.
Role of Rho, Rac, and Rho-kinase in phosphorylation of myosin light chain, development of polarity, and spontaneous migration of Walker 256 carcinosarcoma cells.
Cardiomegaly
Cdc42 is an antihypertrophic molecular switch in the mouse heart.
Common pathways for primary hypertrophic and dilated cardiomyopathy.
Decreased perivascular fibrosis but not cardiac hypertrophy in ROCK1+/- haploinsufficient mice.
Exposure to low dose benzo[a]pyrene during early life stages causes symptoms similar to cardiac hypertrophy in adult zebrafish.
H-Ras Isoform Mediates Protection Against Pressure Overload-Induced Cardiac Dysfunction in Part Through Activation of AKT.
Impact of HMG CoA reductase inhibition on small GTPases in the heart.
MicroRNA-133 controls cardiac hypertrophy.
miR-30c Mediates Upregulation of Cdc42 and Pak1 in Diabetic Cardiomyopathy.
Molecules linked to Ras signaling as therapeutic targets in cardiac pathologies.
Phenanthrene exposure induces cardiac hypertrophy via reducing miR-133a expression by DNA methylation.
Rac1-Mediated Effects of HMG-CoA Reductase Inhibitors (Statins) in Cardiovascular Disease.
Rad GTPase deficiency leads to cardiac hypertrophy.
Rad GTPase inhibits cardiac fibrosis through connective tissue growth factor.
Ral-GTPase interacts with the beta1 subunit of Na+/K+-ATPase and is activated upon inhibition of the Na+/K+ pump.
Redox Signaling by 8-Nitro-cyclic Guanosine Monophosphate: Nitric Oxide- and Reactive Oxygen Species-Derived Electrophilic Messenger.
Role of small GTPase protein Rac1 in cardiovascular diseases: development of new selective pharmacological inhibitors.
Small GTP-binding proteins and their regulators in cardiac hypertrophy.
Cardiomyopathies
Increased myocardial Rab GTPase expression: a consequence and cause of cardiomyopathy.
Cardiomyopathy, Dilated
Common pathways for primary hypertrophic and dilated cardiomyopathy.
Myocardial subproteomic analysis of a constitutively active Rac1-expressing transgenic mouse with lethal myocardial hypertrophy.
Proteomic analysis of Rac1 transgenic mice displaying dilated cardiomyopathy reveals an increase in creatine kinase M-chain protein abundance.
Cardiomyopathy, Hypertrophic
Common pathways for primary hypertrophic and dilated cardiomyopathy.
Molecules linked to Ras signaling as therapeutic targets in cardiac pathologies.
Proteomic Profiling of H-Ras-G12V Induced Hypertrophic Cardiomyopathy in Transgenic Mice Using Comparative LC-MS Analysis of Thin Fresh-Frozen Tissue Sections.
Cardiovascular Diseases
A Functional Relevance of the Anaphylatoxin Receptor C3aR for Platelet Function and Arterial Thrombus Formation Marks an Intersection Point Between Innate Immunity and Thrombosis.
Cellular signaling for activation of Rho GTPase Cdc42.
Contribution of Cdc42 to cholesterol efflux in fibroblasts from Tangier disease and Werner syndrome.
Decreased perivascular fibrosis but not cardiac hypertrophy in ROCK1+/- haploinsufficient mice.
Expression and Activity of the Small RhoGTPase Cdc42 in Blood Cells of Older Adults Are Associated With Age and Cardiovascular Disease.
Gax regulates human vascular smooth muscle cell phenotypic modulation and vascular remodeling.
Guanine nucleotide induced conformational change of Cdc42 revealed by hydrogen/deuterium exchange mass spectrometry.
Peptide modulators of Rac1/Tiam1 protein-protein interaction: An alternative approach for cardiovascular diseases.
Protein Kinase N Promotes Stress-Induced Cardiac Dysfunction Through Phosphorylation of Myocardin-Related Transcription Factor A and Disruption of Its Interaction With Actin.
Role of small GTPase protein Rac1 in cardiovascular diseases: development of new selective pharmacological inhibitors.
Signaling Through Rho GTPase Pathway as Viable Drug Target.
Targeting the mevalonate cascade as a new therapeutic approach in heart disease, cancer and pulmonary disease.
[Involvement of small GTPase Rho in cardiovascular diseases]
Carotid Artery Injuries
Gax regulates human vascular smooth muscle cell phenotypic modulation and vascular remodeling.
Cataract
Impaired cytoskeletal organization and membrane integrity in lens fibers of a Rho GTPase functional knockout transgenic mouse.
Loss-of-function mutations in TBC1D20 cause cataracts and male infertility in blind sterile mice and Warburg micro syndrome in humans.
Celiac Disease
Association of LPP and TAGAP Polymorphisms with Celiac Disease Risk: A Meta-Analysis.
Cell Transformation, Neoplastic
Cooperativity of oncogenic K-ras and downregulated p16/INK4A in human pancreatic tumorigenesis.
Enumeration of the simian virus 40 early region elements necessary for human cell transformation.
FGD1 as a central regulator of extracellular matrix remodelling - lessons from faciogenital dysplasia.
Oncogenic Ras activation of Raf/mitogen-activated protein kinase-independent pathways is sufficient to cause tumorigenic transformation.
Rac1 is required for oncolytic NDV replication in human cancer cells and establishes a link between tumorigenesis and sensitivity to oncolytic virus.
Ral GTPases: corrupting the exocyst in cancer cells.
Tumorigenic transformation of primary rat embryonal fibroblasts by human papillomavirus type 8 E7 gene in collaboration with the activated H-ras gene.
Central Nervous System Diseases
Detection of Small GTPase Prenylation and GTP Binding Using Membrane Fractionation and GTPase-linked Immunosorbent Assay.
Microexon alternative splicing of small GTPase regulators: Implication in central nervous system diseases.
RAS oncogene mutations and outcome of therapy for childhood acute lymphoblastic leukemia.
Rho GTPase-activating proteins: Regulators of Rho GTPase activity in neuronal development and CNS diseases.
Cerebral Hemorrhage
The 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) pathway regulates developmental cerebral-vascular stability via prenylation-dependent signalling pathway.
Cerebral Infarction
Fuyuan Xingnao Decoction Promotes Angiogenesis Through the Rab1/AT1R Pathway in Diabetes Mellitus Complicated With Cerebral Infarction.
Gene transfer of hepatocyte growth factor gene improves learning and memory in the chronic stage of cerebral infarction.
Cervical Intraepithelial Neoplasia
[miR-143 inhibits cell proliferation through targeted regulating the expression of K-ras gene in HeLa cells].
Charcot-Marie-Tooth Disease
Exclusive expression of the Rab11 effector SH3TC2 in Schwann cells links integrin-?6 and myelin maintenance to Charcot-Marie-Tooth disease type 4C.
Myelin is dependent on the Charcot-Marie-Tooth Type 4H disease culprit protein FRABIN/FGD4 in Schwann cells.
The FGD homologue EXC-5 regulates apical trafficking in C. elegans tubules.
Chediak-Higashi Syndrome
Angeborene hämophagozytische Lymphohistiozytose (HLH).
[Defect in lytic granule exocytosis : several causes, a same effect.]
[Hypomelanoses transmitted from generation to generation].
Chlamydia Infections
Rab6 and Rab11 regulate Chlamydia trachomatis development and golgin-84-dependent Golgi fragmentation.
Cholangiocarcinoma
A polysaccharide from Pinellia ternata inhibits cell proliferation and metastasis in human cholangiocarcinoma cells by targeting of Cdc42 and 67kDa Laminin Receptor (LR).
Alterations of the p53 tumor-suppressor gene and K-ras oncogene in perihilar cholangiocarcinomas from a high-incidence area.
An integrated approach for comparative proteomic analysis of human bile reveals overexpressed cancer-associated proteins in malignant biliary stenosis.
Analysis of K-ras gene mutations in periampullary cancers, gallbladder cancers and cholangiocarcinomas from paraffin-embedded tissue sections.
Analysis of microsatellite instability, K-ras gene mutation and p53 protein overexpression in intrahepatic cholangiocarcinoma.
Analysis of ras gene mutations in human hepatic malignant tumors by polymerase chain reaction and direct sequencing.
Cholangiocarcinoma in primary sclerosing cholangitis: K-ras mutations and Tp53 dysfunction are implicated in the neoplastic development.
Cholangiocarcinoma: risk factors, diagnosis and management.
Comparison of K-ras oncogene activation in pancreatic duct carcinomas and cholangiocarcinomas induced in hamsters by N-nitrosobis(2-hydroxypropyl)amine.
Detection of K-ras mutations in the stool of patients with pancreatic adenocarcinoma and pancreatic ductal hyperplasia.
Frequency of p16(INK4A) alterations and K-ras mutations in intrahepatic cholangiocarcinoma of the liver.
K-ras codon 12 and p53 mutations in biopsy specimens and bile from biliary tract cancers.
K-ras Gene Mutations in Liver Carcinomas from a Mediterranean Area of Spain.
K-ras Mutation is Strongly Associated with Perineural Invasion and Represents an Independent Prognostic Factor of Intrahepatic Cholangiocarcinoma after Hepatectomy.
K-ras oncogene and p53 gene mutations in cholangiocarcinoma from Thai patients.
Keap1 deletion accelerates mutant K-ras/p53-driven cholangiocarcinoma.
MEK inhibition suppresses K-Ras wild-type cholangiocarcinoma in vitro and in vivo via inhibiting cell proliferation and modulating tumor microenvironment.
Molecular and immunohistochemical analysis of intraductal papillary neoplasms of the biliary tract.
Molecular Characteristics of Fibrolamellar Hepatocellular Carcinoma.
Multiple K-ras codon 12 mutations in cholangiocarcinomas demonstrated with a sensitive polymerase chain reaction technique.
Mutation of p53 and K-ras, and loss of heterozygosity of APC in intrahepatic cholangiocarcinoma.
Mutational analysis of the p53 and K-ras genes and allelotype study of the Rb-1 gene for investigating the pathogenesis of combined hapatocellular-cholangiocellular carcinomas.
p53?p72??225?331?V31I identified in a cholangiocarcinoma cell line promotes migration and invasiveness via the downregulation of claudin?1 expression and the activation of Cdc42.
S100P immunostaining identifies a subset of peripheral-type intrahepatic cholangiocarcinomas with morphological and molecular features similar to those of perihilar and extrahepatic cholangiocarcinomas.
The incidence of K-ras codon 12 mutations in cholangiocarcinoma detected by polymerase chain reaction technique.
[Detection of ras gene mutations of primary hepatic malignant tumors by polymerase chain reaction and direct sequencing method]
[Molecular genetic approaches in parasitology (in case of opisthorchiasis)]
Cholangitis
K-ras codon 12 and p53 mutations in biopsy specimens and bile from biliary tract cancers.
Cholangitis, Sclerosing
Cholangiocarcinoma in primary sclerosing cholangitis: K-ras mutations and Tp53 dysfunction are implicated in the neoplastic development.
K-ras mutations in the bile of patients with primary sclerosing cholangitis.
Cholecystitis
K-ras codon 12 and p53 mutations in biopsy specimens and bile from biliary tract cancers.
Choledochal Cyst
Biliary papillomatosis with the point mutation of K-ras gene arising in congenital choledochal cyst.
DPC-4 (Smad-4) and K-ras gene mutations in biliary tract epithelium in children with anomalous pancreaticobiliary ductal union.
Cholelithiasis
Molecular analysis to detect pancreatic ductal adenocarcinoma in high-risk groups.
Mutational spectrum of K-ras oncogene among Indian patients with gallbladder cancer.
Cholera
?-Adrenergic receptors suppress Rap1B prenylation and promote the metastatic phenotype in breast cancer cells.
A viral K-RAS protein increases the stimulability of adenylate cyclase by cholera toxin in NRK cells.
ADP-ribosylation factor 6 acts as an allosteric activator for the folded but not disordered cholera toxin A1 polypeptide.
Alterations in the cyclic AMP signal transduction pathway regulating ribonucleotide reductase gene expression in malignant H-ras transformed cell lines.
Calcium mobilization and protease-activated receptor cleavage after thrombin stimulation in motor neurons.
Endothelin 1 stimulates beta1Pix-dependent activation of Cdc42 through the G(salpha) pathway.
Identification of motifs in cholera toxin A1 polypeptide that are required for its interaction with human ADP-ribosylation factor 6 in a bacterial two-hybrid system.
Ornithine decarboxylase gene expression is aberrantly regulated via the cAMP signal transduction pathway in malignant H-ras transformed cell lines.
ras proteins can induce meiosis in Xenopus oocytes.
The cholera toxin A13 subdomain is essential for interaction with ADP-ribosylation factor 6 and full toxic activity but is not required for translocation from the endoplasmic reticulum to the cytosol.
Cholestasis
Cholestasis without cirrhosis alters regulatory liver gene expression and inhibits hepatic regeneration.
Growth-related gene expression in early cholestatic liver injury.
Cholesteatoma
Expression of Ras-related C3 botulinum toxin substrate 1 (RAC1) in human cholesteatoma.
Chondrosarcoma
H-ras oncogene mutation in dedifferentiated chondrosarcoma: polymerase chain reaction-restriction fragment length polymorphism analysis.
Suppressed invasive and migratory behaviors of SW1353 chondrosarcoma cells through the regulation of Src, Rac1 GTPase, and MMP13.
Chordoma
Molecular profiling of chordoma.
Choriocarcinoma
c-myc, c-erbB-2, c-fms and bcl-2 oncoproteins. Expression in normal placenta, partial and complete mole, and choriocarcinoma.
Dome formation induced by v-H-ras oncogene in a human choriocarcinoma cell line.
Establishment of a Choriocarcinoma Model from Immortalized Normal Extravillous Trophoblast Cells Transduced with HRASV12.
RhoE is regulated by cyclic AMP and promotes fusion of human BeWo choriocarcinoma cells.
[Analysis of c-onc genes in choriocarcinoma cells]
[Roles of ras genes on biological properties of human choriocarcinoma cells]
Choroidal Neovascularization
Activation of the Small GTPase Rap1 Inhibits Choroidal Neovascularization by Regulating Cell Junctions and ROS Generation in Rats.
Optimal Inhibition of Choroidal Neovascularization by scAAV2 with VMD2 Promoter-driven Active Rap1a in the RPE.
Retinal pigment epithelial cell expression of active Rap 1a by scAAV2 inhibits choroidal neovascularization.
Choroideremia
cDNA cloning of component A of Rab geranylgeranyl transferase and demonstration of its role as a Rab escort protein.
Mouse genetic corneal disease resulting from transgenic insertional mutagenesis.
Purification of component A of Rab geranylgeranyl transferase: possible identity with the choroideremia gene product.
Rab GTPase prenylation hierarchy and its potential role in choroideremia disease.
Rab27a regulates the peripheral distribution of melanosomes in melanocytes.
Structure of the Rab7:REP-1 complex: insights into the mechanism of Rab prenylation and choroideremia disease.
The Biological Activity of AAV Vectors for Choroideremia Gene Therapy Can Be Measured by In Vitro Prenylation of RAB6A.
Ciliopathies
Crystal structure of the small GTPase Arl6/BBS3 from Trypanosoma brucei.
GTP-binding of ARL-3 is activated by ARL-13 as a GEF and stabilized by UNC-119.
Hexa-Longin domain scaffolds for inter-Rab signalling.
Loss of function IFT27 variants associated with an unclassified lethal fetal ciliopathy with renal agenesis.
Lowe syndrome patient cells display mTOR- and RhoGTPase-dependent phenotypes alleviated by rapamycin and statins.
SUMOylation of the small GTPase ARL-13 promotes ciliary targeting of sensory receptors.
The emerging role of Arf/Arl small GTPases in Cilia and Ciliopathies.
Classical Lissencephalies and Subcortical Band Heterotopias
A Radial Glia-Specific Role of RhoA in Double Cortex Formation.
Small Rho-GTPases and cortical malformations: Fine-tuning the cytoskeleton stability.
Classical Swine Fever
Rab18 binds to classical swine fever virus NS5A and mediates viral replication and assembly in swine umbilical vein endothelial cells.
Rab5, Rab7, and Rab11 Are Required for Caveola-Dependent Endocytosis of Classical Swine Fever Virus in Porcine Alveolar Macrophages.
Cleft Lip
Inactivation of Cdc42 in neural crest cells causes craniofacial and cardiovascular morphogenesis defects.
Cobblestone Lissencephaly
A Radial Glia-Specific Role of RhoA in Double Cortex Formation.
Cockayne Syndrome
Detection of UV-induced K-ras codon 12 mutation by PCR and differential dot-blot hybridization in cells from Down syndrome and Cockayne syndrome.
Coinfection
Functional role of Rab11 in GLUT4 trafficking in cardiomyocytes.
Two distinct EF-Tu epitopes induce immune responses in rice and Arabidopsis.
Use of a novel coinfection system reveals a role for Rac1, H-Ras, and CrkII phosphorylation in Helicobacter pylori-induced host cell actin cytoskeletal rearrangements.
Colitis
Coelomic Fluid of Eisenia fetida Ameliorates Cetuximab to Reduce K-Ras and Vimentin Expression through Promoting RUNX3 in an AOM/DSS-Induced Colitis Associated Colon Cancer.
Involvement of Activated Cdc42 Kinase1 in Colitis and Colorectal Neoplasms.
K-ras mutations and p53 alterations in neoplastic and nonneoplastic lesions associated with longstanding ulcerative colitis.
Prolonged chronic inflammation progresses to dysplasia in a novel rat model of colitis-associated colon cancer.
Rab27A promotes cellular apoptosis and ROS production by regulating the miRNA-124-3p/STAT3/RelA signalling pathway in ulcerative colitis.
Reciprocal Regulation of Glycolysis-Driven Th17 Pathogenicity and Regulatory T Cell Stability by Cdc42.
RhoA and Cdc42 in T cells: Are they targetable for T cell-mediated inflammatory diseases?
Role of the protein tyrosine phosphatase shp2 in homeostasis of the intestinal epithelium.
Colitis, Ulcerative
Activating mutations in the k-ras gene in ulcerative-colitis and crohns-disease.
Aneuploidy mechanisms in human colorectal preneoplastic lesions and Barrett's esophagus. Is there a role for K-ras and p53 mutations?
Genetic alterations in ulcerative colitis-associated neoplasia focusing on APC, K-ras gene and microsatellite instability.
K-ras mutations and p53 alterations in neoplastic and nonneoplastic lesions associated with longstanding ulcerative colitis.
Microsatellite instability and K-ras mutations in patients with ulcerative colitis.
New insights into the interplay between autophagy, gut microbiota and inflammatory responses in IBD.
Overexpression of miR-21 in patients with ulcerative colitis impairs intestinal epithelial barrier function through targeting the Rho GTPase RhoB.
Polypoid growth and K-ras codon 12 mutation in colorectal cancer.
Rab27A promotes cellular apoptosis and ROS production by regulating the miRNA-124-3p/STAT3/RelA signalling pathway in ulcerative colitis.
Screening for p53 and K-ras mutations in whole-gut lavage in chronic inflammatory bowel disease.
Villous, hypermucinous mucosa in long standing ulcerative colitis shows high frequency of K-ras mutations.
[Genome analyses for precancerous lesions in the gastrointestinal tract]
Colitis-Associated Neoplasms
Coelomic Fluid of Eisenia fetida Ameliorates Cetuximab to Reduce K-Ras and Vimentin Expression through Promoting RUNX3 in an AOM/DSS-Induced Colitis Associated Colon Cancer.
Prolonged chronic inflammation progresses to dysplasia in a novel rat model of colitis-associated colon cancer.
Colonic Neoplasms
12th codon mutation resulting in c-N-ras activation in acute myelogenous leukemia.
A non-secretory form of FAM3B promotes invasion and metastasis of human colon cancer cells by upregulating Slug expression.
A novel activating mutation of the K-ras gene in human primary colon adenocarcinoma.
A novel point mutation at codon 146 of the K-ras gene in a human colorectal cancer identified by the polymerase chain reaction.
A novel Ras antagonist regulates both oncogenic Ras and the tumor suppressor p53 in colon cancer cells.
ACB-PCR quantification of K-RAS codon 12 GAT and GTT mutant fraction in colon tumor and non-tumor tissue.
Accomplishments in 2007 in biologic markers for gastrointestinal cancers.
Activated K-ras in tumorigenic and non-tumorigenic cell variants from a rat colon adenocarcinoma, induced by dimethylhydrazine.
Activated K-RAS increases polyamine uptake in human colon cancer cells through modulation of caveolar endocytosis.
Activating mutations in the k-ras gene in ulcerative-colitis and crohns-disease.
Allele-specific detection of K-ras oncogene expression in human non-small-cell lung carcinomas.
Alternative splicing of TIA-1 in human colon cancer regulates VEGF isoform expression, angiogenesis, tumour growth and bevacizumab resistance.
Animal products and K-ras codon 12 and 13 mutations in colon carcinomas.
Anti-EGFR therapeutic efficacy correlates directly with inhibition of STAT3 activity.
Anti-K-ras ribozyme induces growth inhibition and increased chemosensitivity in human colon cancer cells.
Antibody to ras proteins in patients with colon cancer.
Association between H-RAS T81C genetic polymorphism and gastrointestinal cancer risk: a population based case-control study in China.
Association of H-ras polymorphisms and susceptibility to sporadic colon cancer.
Association of K-ras mutations with p16 methylation in human colon cancer.
beta-Catenin mutation is selected during malignant transformation in colon carcinogenesis.
Blocking of p53-Snail binding, promoted by oncogenic K-Ras, recovers p53 expression and function.
BMP-induced growth suppression in colon cancer cells is mediated by p21WAF1 stabilization and modulated by RAS/ERK.
BRAF and RAS oncogenes regulate Rho GTPase pathways to mediate migration and invasion properties in human colon cancer cells: a comparative study.
Carcinogenicity of aminophenylnorharman, a possible novel endogenous mutagen, formed from norharman and aniline, in F344 rats.
Caveolin-1 is a novel regulator of K-RAS-dependent migration in colon carcinogenesis.
CD4+ T-cell immunity to mutated ras protein in pancreatic and colon cancer patients.
Cdc42 is highly expressed in colorectal adenocarcinoma and downregulates ID4 through an epigenetic mechanism.
Characterization of a novel oncogenic K-ras mutation in colon cancer.
Chromogenic in situ hybridization analysis of EGFR gene copies in colon adenocarcinoma based on intra-operative imprints and tissue microarrays.
Clinical impact of K-ras mutation in colorectal cancer patients treated with adjuvant FOLFOX.
Coelomic Fluid of Eisenia fetida Ameliorates Cetuximab to Reduce K-Ras and Vimentin Expression through Promoting RUNX3 in an AOM/DSS-Induced Colitis Associated Colon Cancer.
Coexistence of K-ras mutations and HPV infection in colon cancer.
Colon Cancer: A Clinician's Perspective in 2019.
Colorectal carcinogenesis--update and perspectives.
Combination of dasatinib and curcumin eliminates chemo-resistant colon cancer cells.
Comparative Proteomics Analysis Identifies Cdc42-Cdc42BPA Signaling as Prognostic Biomarker and Therapeutic Target for Colon Cancer Invasion.
Comprehensive genomic analyses of a metastatic colon cancer to the lung by whole exome sequencing and gene expression analysis.
Concurrent mutations of K-ras oncogene at codons 12 and 22 in colon cancer.
Conservation of the genomic structure and receptor-mediated signaling between human and rat IL-24.
Cytotoxic drugs up-regulate epidermal growth factor receptor (EGFR) expression in colon cancer cells and enhance their susceptibility to EGFR-targeted antibody-dependent cell-mediated-cytotoxicity (ADCC).
Detection of K-ras mutations in azoxymethane-induced aberrant crypt foci in mice using LNA -mediated real-time PCR clamping and mutant-specific probes.
Detection of mutated K12-ras in histologically negative lymph nodes as an indicator of poor prognosis in stage II colorectal cancer.
Detection of occult metastases in sentinel lymph nodes from colon cancer patients by K-ras mutation peptide nucleic acid clamp PCR.
Dietary folate intake and k-ras mutations in sporadic colon and rectal cancer in The Netherlands Cohort Study.
Dietary phytate lowers K-ras mutational frequency, decreases DNA-adduct and hydroxyl radical formation in azoxymethane-induced colon cancer.
Dietary supplementation of lutein reduces colon carcinogenesis in DMH-treated rats by modulating K-ras, PKB, and ?-catenin proteins.
Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon.
Direct Correlation Between Double K-RAS Mutation and Mucinous Carcinoma. A Case Report.
Distinguishable Prognostic Signatures of Left- and Right-Sided Colon Cancer: a Study Based on Sequencing Data.
DNA mutation detection with chip-based temperature gradient capillary electrophoresis using a slantwise radiative heating system.
Dose-dependent effect of dietary meat on endogenous colonic N-nitrosation.
Duodenal cancer in a patient with Peutz-Jeghers syndrome: molecular analysis.
Effect of the farnesyl transferase inhibitor L-744,832 on the colon cancer cell line DLD-1 and its combined use with radiation and 5-FU.
Engineering plasmonic nanorod arrays for colon cancer marker detection.
ERK/pERK expression, B-raf and K-ras mutations in colon adenocarcinomas: correlation with clinicopathological characteristics and expression of hMLH1 and hMSH2.
Essential role of p38gamma in K-Ras transformation independent of phosphorylation.
Essential role of the JAK/STAT1 signaling pathway in the expression of inducible nitric-oxide synthase in intestinal epithelial cells and its regulation by butyrate.
Evidence for a ras gene mutation in azoxymethane-induced colonic aberrant crypts in Sprague-Dawley rats: earliest recognizable precursor lesions of experimental colon cancer.
Expression of facilitative glucose transporter 1 mRNA in colon cancer was not regulated by k-ras.
Expression of pro-angiogenic factors as potential biomarkers in experimental models of colon cancer.
Expression of protooncogene-encoded mRNA by colonic epithelial cells in inflammatory bowel disease.
Extracted metabolite from
From colonic polyps to colon cancer: pathophysiology, clinical presentation, screening and colonoscopic therapy.
G?13/PDZ-RhoGEF/RhoA signaling is essential for gastrin-releasing peptide receptor-mediated colon cancer cell migration.
Gene targeting approach to selectively kill colon cancer cells, with hyperactive K-Ras pathway.
Genetic alterations in locally advanced stage II/III colon cancer: a search for prognostic markers.
Genetic alterations of K-ras may reflect prognosis in stage III colon cancer patients below 60 years of age.
Genetic analysis of DNA excreted in urine: a new approach for detecting specific genomic DNA sequences from cells dying in an organism.
Genetic pathways in the evolution of morphologically distinct colorectal neoplasms.
Glucose-6-Phosphate Dehydrogenase Is Not Essential for K-Ras-Driven Tumor Growth or Metastasis.
Growth inhibition of a colonic adenocarcinoma cell line (HT29) by T cells specific for mutant p21 ras.
Heterogeneous distribution of K-ras mutations in primary colon carcinomas: implications for EGFR-directed therapy.
Hyperprogressive Disease in an Advanced Stage Colon Cancer Patient on Pembrolizumab: A Case Report.
Hypoxia activates the K-ras proto-oncogene to stimulate angiogenesis and inhibit apoptosis in colon cancer cells.
Hypoxia-inducible factor-1-independent regulation of vascular endothelial growth factor by hypoxia in colon cancer.
Hypoxic regulation of vascular endothelial growth factor through the induction of phosphatidylinositol 3-kinase/Rho/ROCK and c-Myc.
Identification and characterization of a diamine exporter in colon epithelial cells.
Identification of a ternary protein-complex as a therapeutic target for K-Ras-dependent colon cancer.
IGF-1R inhibition induces MEK phosphorylation to promote survival in colon carcinomas.
IMP-1 Displays Cross-Talk with K-Ras and Modulates Colon Cancer Cell Survival through the Novel Proapoptotic Protein CYFIP2.
Impairment of K-Ras signaling networks and increased efficacy of EGFR inhibitors by a novel synthetic miR-143.
Increase in the frequency of K-ras codon 12 point mutation in colorectal carcinoma in elderly males in Japan: the 1990s compared with the 1960s.
Increased diacylglycerol kinase ? expression in human metastatic colon cancer cells augments Rho GTPase activity and contributes to enhanced invasion.
Induction of micronuclei by a new non-peptidic mimetic farnesyltransferase inhibitor RPR-115135: role of gene mutations.
Inhibition of miR-193a Expression by Max and RXR{alpha} Activates K-Ras and PLAU to Mediate Distinct Aspects of Cellular Transformation.
Inhibition of protein farnesylation enhances the chemotherapeutic efficacy of the novel geranylgeranyltransferase inhibitor BAL9611 in human colon cancer cells.
Interaction of molecular markers and physical activity on mortality in patients with colon cancer.
Inverse relationship between microsatellite instability and K-ras and p53 gene alterations in colon cancer.
Involvement of K-RAS mutations and amino acid substitutions in the survival of metastatic colorectal cancer patients.
Irinotecan hydrochloride (CPT-11) resistance identified by K-ras mutation in patients with progressive colon cancer after treatment with 5-fluorouracil (5-FU).
Is the Effect of Tumor Localization on Prognosis Compatible with Real-life Data in Metastatic Colon Cancer? Single-Center Experience: A Retrospective Analysis.
Isolation of a chemical inhibitor against K-Ras-induced p53 suppression through natural compound screening.
Isolation of a novel member of small G protein superfamily and its expression in colon cancer.
K-ras and p53 mutations in aberrant crypt foci and colonic tumors from colon cancer patients.
K-ras gene mutation as an early prognostic marker of colon cancer.
K-ras mutation in the major duodenal papilla and gastric and colonic mucosa in patients with autoimmune pancreatitis.
K-RAS mutation in the screening, prognosis and treatment of cancer.
K-ras mutations are correlated to lymph node metastasis and tumor stage, but not to the growth pattern of colon carcinoma.
K-ras mutations in aberrant crypt foci, adenomas and adenocarcinomas during azoxymethane-induced colon carcinogenesis.
K-ras mutations in putative preneoplastic lesions in human colon.
K-RAS point mutation, and amplification of C-MYC and C-ERBB2 in colon adenocarcinoma.
K-ras point mutations in routinely processed tissues: non-radioactive screening by single strand conformational polymorphism analysis.
K-Ras, Intestinal Homeostasis and Colon Cancer.
Kallikrein 6 is a mediator of K-RAS-dependent migration of colon carcinoma cells.
KRAS insertion mutations are oncogenic and exhibit distinct functional properties.
Leptin promotes motility and invasiveness in human colon cancer cells by activating multiple signal-transduction pathways.
Lessons from the genetics of colon cancer.
Liver metastasis models of colon cancer for evaluation of drug efficacy using NOD/Shi-scid IL2Rgammanull (NOG) mice.
Manumycin inhibits ras signal transduction pathway and induces apoptosis in COLO320-DM human colon tumour cells.
Mast Cell Targeted Chimeric Toxin Can Be Developed as an Adjunctive Therapy in Colon Cancer Treatment.
microRNA-214 functions as a tumor suppressor in human colon cancer via the suppression of ADP-ribosylation factor-like protein 2.
Microsatellite alterations and K-ras, TGFbetaRII, IGFRII and bax mutations in sporadic cancers of the gastrointestinal tract.
Microvessel density, cyclo-oxygenase 2 expression, K-ras mutation and p53 overexpression in colonic cancer.
Molecular biology of colorectal cancer.
Mutant K-ras oncogenes in colon cancers Do not predict Patient's chemotherapy response or survival
MUTYH exon 7 and 13 mutations associated with colorectal cancer (MAP syndrome) are not commonly associated with sporadic pancreatic cancer.
N-ras protein: frequent quantitative and qualitative changes occur in human colorectal carcinomas.
New peptide vaccine candidates for epithelial cancer patients with HLA-A3 supertype alleles.
No back seat for a progression event-K-RAS as a therapeutic target in CRC.
Nox1 is over-expressed in human colon cancers and correlates with activating mutations in K-Ras.
Oncogenic K-ras confers SAHA resistance by up-regulating HDAC6 and c-myc expression.
Oncogenic K-RAS is required to maintain changes in cytoskeletal organization, adhesion, and motility in colon cancer cells.
Oncogenic K-ras promotes early carcinogenesis in the mouse proximal colon.
Oncogenic K-ras stimulates Wnt signaling in colon cancer through inhibition of GSK-3beta.
Oncogenic Pathways and Loss of the Rab11 GTPase Synergize To Alter Metabolism in Drosophila.
Oncogenic ras induces gastrin gene expression in colon cancer.
p38 MAPK activation selectively induces cell death in K-ras-mutated human colon cancer cells through regulation of vitamin D receptor.
p53 Activation by Blocking Snail : A Novel Pharmacological Strategy for Cancer.
p53 and K-ras gene mutations in carcinoma of the rectum among Finnish women.
Personalized medicine and oncology practice guidelines: a case study of contemporary biomarkers in colorectal cancer.
Phytohemagglutinin-L (PHA-L) lectin surface binding of N-linked beta 1-6 carbohydrate and its relationship to activated mutant ras in human pancreatic cancer cell lines.
Primary cancer of the small intestine and mutational analysis of the K-ras and p53 genes.
Prognostic role of K-ras in patients with progressive colon cancer who received treatment with Marimastat (BB2516).
Prognostic significance of K-ras and TP53 mutations in the role of adjuvant chemotherapy on survival in patients with Dukes C colon cancer.
PTHrP promotes colon cancer cell migration and invasion in an integrin ?6?4-dependent manner through activation of Rac1.
PTP-PEST controls motility, adherens junction assembly, and Rho GTPase activity in colon cancer cells.
Rab11 collaborates E-cadherin to promote collective cell migration and indicates a poor prognosis in colorectal carcinoma.
Rab27A mediated by NF-?B promotes the stemness of colon cancer cells via up-regulation of cytokine secretion.
Rab3 proteins and cancer: Exit strategies.
Ras mutation, irrespective of cell type and p53 status, determines a cell's destiny to undergo apoptosis by okadaic acid, an inhibitor of protein phosphatase 1 and 2A.
RAS Mutations Affect Tumor Necrosis Factor-Induced Apoptosis in Colon Carcinoma Cells via ERK-Modulatory Negative and Positive Feedback Circuits Along with Non-ERK Pathway Effects.
Rational combination of MEK inhibitor and the STAT3 pathway modulator for the therapy in K-Ras mutated pancreatic and colon cancer cells.
Reciprocal regulation of extracellular signal regulated kinase 1/2 and mitogen activated protein kinase phosphatase-3.
Rheb promotes cancer cell survival through p27Kip1-dependent activation of autophagy.
Rho GTPase Rac1: molecular switch within the galectin network and for N-glycan ?2,6-sialylation/O-glycan core 1 sialylation in colon cancer in vitro.
Ribozyme-mediated inactivation of mutant K-ras oncogene in a colon cancer cell line.
Role of genetic polymorphisms and mutations in colorectal cancer therapy (Review).
S-adenosylmethionine inhibits the growth of cancer cells by reversing the hypomethylation status of c-myc and H-ras in human gastric cancer and colon cancer.
Secretory RAB GTPase 3C modulates IL6-STAT3 pathway to promote colon cancer metastasis and is associated with poor prognosis.
shRNA-induced silencing of Ras-related C3 botulinum toxin substrate 1 inhibits the proliferation of colon cancer cells through upregulation of BAD and downregulation of cyclin D1.
Small Molecule Destabilizer of ?-Catenin and Ras Proteins Antagonizes Growth of K-Ras Mutation-Driven Colorectal Cancers Resistant to EGFR Inhibitors.
Sprouty-2 controls c-Met expression and metastatic potential of colon cancer cells: sprouty/c-Met upregulation in human colonic adenocarcinomas.
STAT1 Represses Skp2 Gene Transcription to Promote p27Kip1 Stabilization in Ras-Transformed Cells.
Successful Multidisciplinary Treatment with Secondary Metastatic Liver Resection after Downsizing by Palliative Second-Line Treatment of Colorectal Cancer: A Curative Option.
Suppression of pancreatic and colon cancer cells by antisense K-ras RNA expression vectors.
Targeted disruption of the K-ras oncogene in an invasive colon cancer cell line down-regulates urokinase receptor expression and plasminogen-dependent proteolysis.
Targeted Intestinal Deletion of Rho Guanine Nucleotide Exchange Factor 7, ?PIX, Impairs Enterocyte Proliferation, Villus Maturation and Mucosal Defenses in Mice.
Targeting Cdc42 with the small molecule drug AZA197 suppresses primary colon cancer growth and prolongs survival in a preclinical mouse xenograft model by downregulation of PAK1 activity.
Targeting transforming growth factor-beta signaling in liver metastasis of colon cancer.
Testosterone induced apoptosis in colon cancer cells is regulated by PI3K/Rac1 signaling.
The capacity for growth stimulation by TGF beta 1 seen only in advanced colon cancers cannot be ascribed to mutations in APC, DCC, p53 or ras.
The Critical Role of Dysregulated RhoB Signaling Pathway in Radioresistance of Colorectal Cancer.
The Evi1, microRNA-143, K-Ras axis in colon cancer.
The ras gene family in human non-small-cell lung cancer.
The Ras inhibitor S-trans,trans-farnesylthiosalicylic acid chemosensitizes human tumor cells without causing resistance.
The role of DNA hypermethylation in human neoplasia.
The role of ras gene mutation in gastric cancer and precancerous lesions.
The Wnt/beta-catenin pathway regulates growth and maintenance of colonospheres.
Transforming growth factor-beta1 modulates metalloproteinase-2 and -9, nitric oxide, RhoA and alpha-smooth muscle actin expression in colon adenocarcinoma cells.
Tumor suppressors miR-143 and miR-145 and predicted target proteins API5, ERK5, K-RAS, and IRS-1 are differentially expressed in proximal and distal colon.
Tumour markers in colorectal cancer: European Group on Tumour Markers (EGTM) guidelines for clinical use.
Upregulation of non-mutated H-ras and its upstream and downstream signaling proteins in colorectal cancer.
Upregulation of polycistronic microRNA-143 and microRNA-145 in colonocytes suppresses colitis and inflammation-associated colon cancer.
Ursodeoxycholic acid inhibits Ras mutations, wild-type Ras activation, and cyclooxygenase-2 expression in colon cancer.
Use of isogenic human cancer cells for high-throughput screening and drug discovery.
Wnt signaling can repress thrombospondin-1 expression in colonic tumorigenesis.
[A case of liver metastasis treated by cetuximab monotherapy with partial response]
[CD4+ T-cell immunity and Ab responses to mutant ras protein in pancreas and colon cancer patients]
[Detection of K-ras mutations in colon cancer by PHA-PHFA (preferential homoduplex formation assay)]
[Detection of ras gene mutation in various stages of gastric cancer by PCR/RFLP SSCP and DNA sequencing]
[Effects of K-ras gene mutation on colon cancer cell line Caco-2 metastasis by regulating E-cadherin/beta-catenin/p120 protein complex formation and RhoA protein activity]
[K-ras mutational status and tumour-infiltrating lymphocytes in human colon cancer: state of the art and future perspectives].
[Mutations of APC and K-ras gene in aberrant crypt foci from human colon]
[Standardization of evaluation for target molecule in cancer therapy].
[The effect of small GTPase Cdc42 on the multidrug resistance of oxaliplatin-resistant colon cancer cell lines].
[The expressions of K-ras in human laryngeal squamous cell carcinoma cell lines (Hep-2) and its significance]
Colorectal Neoplasms
5-Arylidene(chromenyl-methylene)-thiazolidinediones: Potential New Agents against Mutant Oncoproteins K-Ras, N-Ras and B-Raf in Colorectal Cancer and Melanoma.
?-catenin and K-ras mutations and RASSF1A promoter methylation in Taiwanese colorectal cancer patients.
?Np63? suppresses cells invasion by downregulating PKC?/Rac1 signaling through miR-320a.
A case of syncronised hereditery nonpoliposis colorectal tumor with different hystopathological type and k-ras gene mutation: case report.
A colorimetric method for point mutation detection using high-fidelity DNA ligase.
A detailed analysis of K-ras point mutations in relation to tumor progression and survival in colorectal cancer patients.
A detailed analysis of the role of K-ras gene mutation in the progression of colorectal adenoma.
A highly sensitive method for K-ras mutation detection is useful in diagnosis of gastrointestinal cancer.
A K-ras 13Gly-->Asp mutation is recognized by HLA-DQ7 restricted T cells in a patient with colorectal cancer. Modifying effect of DQ7 on established cancers harbouring this mutation?
A miniaturized spatial temperature gradient capillary electrophoresis system with radiative heating and automated sample introduction for DNA mutation detection.
A newly identified pattern of K-ras mutations at codons 12 and 13 is associated with long-term survival in colorectal cancer.
A novel gene containing PDZ and LIM domains, PCD1, is overexpressed in human colorectal cancer.
A novel high-specificity approach for colorectal neoplasia: Detection of K-ras2 oncogene mutation in normal mucosa.
A novel K-ras mutation in colorectal cancer. A case report and literature review.
A novel mutant allele specific amplification and electrochemiluminescence method for the detection of point mutation in clinical samples.
A novel point mutation at codon 146 of the K-ras gene in a human colorectal cancer identified by the polymerase chain reaction.
A rapid PCR ELISA for the detection of activated K-ras in colorectal cancer.
A relationship between K-ras gene mutations and some clinical and histologic variables in patients with primary colorectal carcinoma.
A sensitive fluorescence anisotropy method for point mutation detection by using core-shell fluorescent nanoparticles and high-fidelity DNA ligase.
A simple method of detecting K-ras point mutations in stool samples for colorectal cancer screening using one-step polymerase chain reaction/restriction fragment length polymorphism analysis.
A study of ras gene mutations in colonic adenomas from familial polyposis coli patients.
A very large villous adenoma with an adjacent cancer of the rectum: an informative case for testing the proposed molecular basis of colorectal tumorigenesis.
Acquisition of anoikis resistance promotes the emergence of oncogenic K-ras mutations in colorectal cancer cells and stimulates their tumorigenicity in vivo.
Activating K-Ras mutations outwith 'hotspot' codons in sporadic colorectal tumours - implications for personalised cancer medicine.
Activation of extracellular regulated kinases (ERK1/2) but not AKT predicts poor prognosis in colorectal carcinoma and is associated with k-ras mutations.
Activation of K-RAS by co-mutation of codons 19 and 20 is transforming.
Activation of Rho GTPase Cdc42 promotes adhesion and invasion in colorectal cancer cells.
Activation of the K-ras oncogene in colorectal neoplasms is associated with decreased apoptosis.
Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth.
Advances in Molecular Pathology and Treatment of Periampullary Cancers.
Ag3PO4 NP@MoS2 nanosheet enhanced F, S-doped BN quantum dot electrochemiluminescence biosensor for K-ras tumor gene detection.
Age-associated loss of heterozygosity of tumor suppressor genes in the gastric mucosa of humans.
Agreement between K-ras sequence variations detected in plasma and tissue DNA in pancreatic and colorectal cancer.
AKAP-9 promotes colorectal cancer development by regulating Cdc42 interacting protein 4.
Alterations in K-ras, APC and p53-multiple genetic pathway in colorectal cancer among Indians.
Alterations of K-ras and p53 mutations in colorectal cancer patients in Central Europe.
Alterations of p53 and k-ras genes in human colorectal-cancer with ulcerative-colitis.
Alterations of the K-ras and p53 genes and microsatellite instability in sporadic colorectal carcinomas.
Amplification refractory mutation system linear extension: a novel, gel-free, enzyme-linked immunoassay method for DNA genotyping.
Analysis of HER-3, insulin growth factor-1, nuclear factor-kB and epidermal growth factor receptor gene copy number in the prediction of clinical outcome for K-RAS wild-type colorectal cancer patients receiving irinotecan-cetuximab.
Analysis of K-ras codon 12 and TP53 mutations in patients with advanced colorectal carcinoma.
Analysis of K-ras codon 12 mutations and p53 overexpression in colorectal nodule-aggregating tumors.
Analysis of K-ras in the stools of patients with colorectal tumors.
Analysis of mutant K-ras in multiple sites of normal appearing mucosa of colorectal cancer patients.
Analysis of potential predictive markers of cetuximab benefit in BMS099, a phase III study of cetuximab and first-line taxane/carboplatin in advanced non-small-cell lung cancer.
Analysis of RIN1 gene expression in colorectal cancer.
Analysis of the anatomic subsites, gender and age in unresectable advanced colorectal carcinomas in Tochigi, Japan suggests a shift in location towards the right side colon in elderly patients treated with cetuximab.
Analysis of the K-ras/B-raf/Erk signal cascade, p53 and CMAP as markers for tumor progression in colorectal cancer patients.
ANIMAL MODELS FOR COLORECTAL CANCER.
APC and p53 mutations in de novo colorectal adenocarcinomas.
APC loss-induced intestinal tumorigenesis in Drosophila: Roles of Ras in Wnt signaling activation and tumor progression.
APC mutations are sufficient for the growth of early colorectal adenomas.
APC, K-ras, and p53 gene mutations in colorectal cancer patients: correlation to clinicopathologic features and postoperative surveillance.
Application of cycling gradient capillary electrophoresis to detection of APC, K-ras, and DCC point mutations in patients with sporadic colorectal tumors.
Approaching real-time molecular diagnostics: single-pair fluorescence resonance energy transfer (spFRET) detection for the analysis of low abundant point mutations in K-ras oncogenes.
Are high initial CEA and CA 19-9 levels associated with the presence of K-ras mutation in patients with metastatic colorectal cancer?
Assessment of K-ras mutation: a step toward personalized medicine for patients with colorectal cancer.
Assessment of somatic k-RAS mutations as a mechanism associated with resistance to EGFR-targeted agents: a systematic review and meta-analysis of studies in advanced non-small-cell lung cancer and metastatic colorectal cancer.
Association between H-ras minisatellite and colorectal cancer risk.
Association of folate intake, dietary habits, smoking and COX-2 promotor -765G>C polymorphism with K-ras mutation in patients with colorectal cancer.
Association of K-ras mutational status and clinical outcomes in patients with metastatic colorectal cancer receiving panitumumab alone.
Association of K-ras mutations with liver metastases from colorectal carcinoma.
Association of k-ras, b-raf, and p53 status with the treatment effect of bevacizumab.
Association of KRAS gene mutations with depression in older metastatic colorectal cancer patients.
Association of the SS genotype of the L-myc gene and loss of 18q sequences with a worse clinical prognosis in colorectal cancers.
beta-Catenin and ras oncogenes detect most human colorectal cancer.
Biological consequences of the genetic changes which occur during human colorectal carcinogenesis.
Biweekly cetuximab and first-line chemotherapy in chinese patients with k-ras wild-type colorectal cancers.
Can K-ras gene mutation be utilized as prognostic biomarker for colorectal cancer patients receiving chemotherapy? A meta-analysis and systematic review.
Carfilzomib Promotes the Unfolded Protein Response and Apoptosis in Cetuximab-Resistant Colorectal Cancer.
Caveolin-1 mediates the expression and localization of cathepsin B, pro-urokinase plasminogen activator and their cell-surface receptors in human colorectal carcinoma cells.
CDC42 inhibition suppresses progression of incipient intestinal tumors.
Cdc42 is highly expressed in colorectal adenocarcinoma and downregulates ID4 through an epigenetic mechanism.
Cdc42 subcellular relocation in response to VEGF/NRP1 engagement is associated with the poor prognosis of colorectal cancer.
cDNA sequencing improves the detection of P53 missense mutations in colorectal cancer.
Cetuximab in the first-line treatment of K-ras wild-type metastatic colorectal cancer: the choice and schedule of fluoropyrimidine matters.
Cetuximab rechallenge in metastatic colorectal cancer patients: how to come away from acquired resistance?
Cetuximab-based therapy for metastatic colorectal cancer: a meta-analysis of the effect of K-ras mutations.
Characteristics in primary signet-ring cell carcinoma of the colorectum, from clinicopathological observations.
Cigarette smoking and K-ras mutations in pancreas, lung and colorectal adenocarcinomas: Etiopathogenic similarities, differences and paradoxes.
Clinical impact of K-ras mutation in colorectal cancer patients treated with adjuvant FOLFOX.
Clinical relevance of the transcriptional signature regulated by CDC42 in colorectal cancer.
Clinical retrospective study on the expression of the PD-L1 molecule in sporadic colorectal cancer and its correlation with K-ras gene mutations in Chinese patients.
Clinical significance of K-ras and BRAF mutations in Chinese colorectal cancer patients.
Clinical significance of K-Ras mutations in intraoperative tumor drainage blood from patients with colorectal carcinoma.
Clinical significance of p53, K-ras and DCC gene alterations in the stage I-II colorectal cancers.
Clinical usefulness of K-RAS mutation detection in colorectal cancer and in surgical margins of the colon.
Clinical validation of colorectal cancer biomarkers identified from bioinformatics analysis of public expression data.
Clinical-pathological correlation of K-Ras mutation and ERK phosphorylation in colorectal cancer.
Clinico-pathological study of K-ras mutations in colorectal tumors in Saudi Arabia.
Clinico-Pathological Study of K-ras Mutations in Colorectal Tumors: A Single-Center Retrospective Study of 51 Patients in Madinah, Saudi Arabia.
Clinicopathologic and carcinogenetic appraisal of DNA replication error in sporadic T3N0M0 stage colorectal cancer after curative resection.
Clinicopathological and protein characterization of BRAF- and K-RAS-mutated colorectal cancer and implications for prognosis.
Clinicopathological Associations of K-RAS and N-RAS Mutations in Indonesian Colorectal Cancer Cohort.
Clonal analysis of colorectal tumors using K-ras and p53 gene mutations as markers.
Coexistence of K-ras mutations and HPV infection in colon cancer.
Colonic Paneth cell metaplasia is pre-neoplastic condition of colonic cancer or not?
Colorectal adenoma to carcinoma progression follows multiple pathways of chromosomal instability.
Colorectal cancer prognosis: is it all mutation, mutation, mutation?
Colorectal cancer screening - Methodology.
Colorectal cancer: using blood samples and tumor tissue to detect K-ras mutations.
Combined analysis of microsatellite instability and K-ras mutation increases detection incidence of normal samples from colorectal cancer patients.
Comparative Screening of K-ras Mutations in Colorectal Cancer and Lung Cancer Patients Using a Novel Real-Time PCR with ADx-K-ras Kit and Sanger DNA Sequencing.
Comparative study of mutations in SNP loci of K-RAS, hMLH1 and hMSH2 genes in neoplastic intestinal polyps and colorectal cancer.
Comparison of a PNA clamp PCR and an ARMS/Scorpion PCR assay for the detection of K-ras mutations.
Comparison of clinicopathologic characteristics and genetic alterations between microsatellite instability-positive and microsatellite instability-negative sporadic colorectal carcinomas in patients younger than 40 years old.
Comparison of K-ras mutations in lung, colorectal and gastric cancer.
Concurrent mutation in exons 1 and 2 of the K-ras oncogene in colorectal cancer.
Concurrent mutations of K-ras oncogene at codons 12 and 22 in colon cancer.
Contrasting molecular pathology of colorectal carcinoma in Egyptian and Western patients.
Control of colorectal metastasis formation by K-Ras.
Cooperative anti-invasive effect of Cdc42/Rac1 activation and ROCK inhibition in SW620 colorectal cancer cells with elevated blebbing activity.
Correlation of K-ras codon 12 mutations in human feces and ages of patients with colorectal cancer (CRC).
Corrigendum: Tetrac and NDAT Induce Anti-proliferation via Integrin ?v?3 in Colorectal Cancers With Different K-RAS Status.
Cost-effectiveness of targeted therapy with cetuximab in patients with K-ras wild-type colorectal cancer presenting with initially unresectable metastases limited to the liver in a German setting.
CpG island promoter hypermethylation of a novel Ras-effector gene RASSF2A is an early event in colon carcinogenesis and correlates inversely with K-ras mutations.
Critical Role of p53 and K-ras in the Diagnosis of Early Colorectal Cancer: a One-year, Single-center Analysis.
CSE1L modulates Ras-induced cancer cell invasion: correlation of K-Ras mutation and CSE1L expression in colorectal cancer progression.
Cyclin D1 overexpression in colorectal carcinoma in vivo is dependent on beta-catenin protein dysregulation, but not k-ras mutation.
Cyclooxygenase-2 overexpression is related to polypoid growth and K-ras gene mutation in T1 colorectal carcinomas.
Decreased expression of Rab27A and Rab27B correlates with metastasis and poor prognosis in colorectal cancer.
Deleted in colorectal cancer binding netrin-1 mediates cell substrate adhesion and recruits Cdc42, Rac1, Pak1, and N-WASP into an intracellular signaling complex that promotes growth cone expansion.
Detecting K-ras mutations in stool from fecal occult blood test cards in multiphasic screening for colorectal cancer.
Detection of a K-ras mutation in urine of patients with colorectal cancer.
Detection of APC and k-ras mutations in the serum of patients with colorectal cancer.
Detection of codon 61 point mutations of the K-ras gene in lung and colorectal cancers by enriched PCR.
Detection of colorectal cancer K-ras mutations using a simplified oligonucleotide ligation assay.
Detection of isolated tumor cells by polymerase chain reaction-restriction fragment length polymorphism for K-ras mutations in tissue samples of 199 colorectal cancer patients.
Detection of K-ras mutation in colonic effluent samples from patients without evidence of colorectal carcinoma.
Detection of K-ras mutation in sputum by mutant-allele-specific amplification (MASA).
Detection of K-ras mutations in DNAs isolated from feces of patients with colorectal tumors by mutant-allele-specific amplification (MASA).
Detection of K-ras Mutations in Predicting Efficacy of Epidermal Growth Factor Receptor Tyrosine Kinase (EGFR-TK) Inhibitor in Patients with Metastatic Colorectal Cancer.
Detection of K-ras mutations in stools of patients with colorectal cancer by mutant-enriched PCR.
Detection of K-ras point mutations in mesenteric venous blood from colorectal cancer patients by enriched polymerase chain reaction and single-strand conformation polymorphism analysis.
Detection of K-ras point mutations in the supernatants of peritoneal and pleural effusions for diagnosis complementary to cytologic examination.
Detection of low-level DNA mutation by ARMS-blocker-Tm PCR.
Detection of mutant K-ras DNA in plasma or serum of patients with colorectal cancer.
Detection of mutated K-ras DNA in urine, plasma, and serum of patients with colorectal carcinoma or adenomatous polyps.
Detection of oncogene mutation from neoplastic colonic cells exfoliated in feces.
Detection of somatic DNA alterations in azoxymethane-induced F344 rat colon tumors by random amplified polymorphic DNA analysis.
Detection of the mutated K-Ras biomarker in colorectal carcinoma.
Detection of tumor cells in blood using CD45 magnetic cell separation followed by nested mutant allele-specific amplification of p53 and K-ras genes in patients with colorectal cancer.
Detection of tumor DNA in serum of colorectal cancer patients.
Determination of Circulating Tumor Cells for Prediction of Recurrent Colorectal Cancer Progression.
Determination of microsatellite instability, p53 and K-RAS mutations in hepatic metastases from patients with colorectal cancer: relationship with response to 5-fluorouracil and survival.
Development of a ligase detection reaction/CGE method using a LIF dual-channel detection system for direct identification of allelic composition of mutated DNA in a mixed population of excess wild-type DNA.
Diagnostic biochip array for fast and sensitive detection of K-ras mutations in stool.
Diet and K-ras mutations in colorectal cancer.
Dietary folate and APC mutations in sporadic colorectal cancer.
Dietary, lifestyle and clinicopathological factors associated with BRAF and K-ras mutations arising in distinct subsets of colorectal cancers in the EPIC Norfolk study.
Differences in gene mutations according to gender among patients with colorectal cancer.
Differences in the frequencies of K-ras c12-13 genotypes by gender and pathologic phenotypes in colorectal tumors measured using the allele discrimination method.
Different genetic pathways to proximal and distal colorectal cancer influenced by sex-related factors.
Different types of K-Ras mutations are conversely associated with overall survival in patients with colorectal cancer.
Differential colorectal carcinogenesis: Molecular basis and clinical relevance.
Differential Expression of IL-17, 22 and 23 in the Progression of Colorectal Cancer in Patients with K-ras Mutation: Ras Signal Inhibition and Crosstalk with GM-CSF and IFN-?.
Differing DNA methylation patterns and gene mutation frequencies in colorectal carcinomas from Middle Eastern countries.
Discordance between K-ras mutations in bone marrow micrometastases and the primary tumor in colorectal cancer.
Discrepancies between the K-ras mutational status of primary colorectal cancers and corresponding liver metastases are found in codon 13.
Discriminative detection of low-abundance point mutations using a PCR/ligase detection reaction/capillary gel electrophoresis method and fluorescence dual-channel monitoring.
Disseminated colorectal tumor cells in organs prone to metastasis detected by new double enriched nested-PCR in comparison with recognized assays.
Distinct genetic profiles in colorectal tumors with or without the CpG island methylator phenotype.
Distinct K-ras mutation pattern characterizes signet ring cell colorectal carcinoma.
Distribution of genetic variants in preneoplastic areas of colorectal tumours.
DNA alkylation and repair in the large bowel: animal and human studies.
DNA alterations in sporadic colorectal tumors do not correlate with tumor staging diagnosed by the TNM system.
DNA alterations of microsatellite DNA, p53, APC and K-ras in Chinese colorectal cancer patients.
Does increased endogenous formation of N-nitroso compounds in the human colon explain the association between red meat and colon cancer?
Down-regulation of Cdx2 in colorectal carcinoma cells by the Raf-MEK-ERK 1/2 pathway.
Downregulation of epidermal growth factor receptor family receptors and ligands in a mutant K-ras group of patients with colorectal cancer.
Early FDG/PET scanning as a pharmacodynamic marker of anti-EGFR antibody activity in colorectal cancer.
Early prediction by 18F-FDG PET/CT for progression-free survival and overall survival in patients with metastatic colorectal cancer receiving third-line cetuximab-based therapy.
Effect of K-ras mutation on morphogenesis of colorectal adenomas and early cancers: relationship to distribution of proliferating cells.
Efficacy of Oxaliplatin/5-Fluorouracil/Capecitabine-Cetuximab Combination Therapy and Its Effects on K-Ras Mutations in Advanced Colorectal Cancer.
EGFR-targeted TRAIL and a Smac mimetic synergize to overcome apoptosis resistance in KRAS mutant colorectal cancer cells.
Electrochemical biosensor based on functional composite nanofibers for detection of K-ras gene via multiple signal amplification strategy.
Eligibility of real-world patients with chemo-refractory, K-RAS wild-type, metastatic colorectal cancer for palliative intent regorafenib monotherapy.
Endogenous TNF inducibility and prognosis of colorectal cancer.
EP4 upregulation of Ras signaling and feedback regulation of Ras in human colon tissues and cancer cells.
Epidermal Growth Factor Receptor (EGFR) gene copy number (GCN) correlates with clinical activity of irinotecan-cetuximab in K-RAS wild-type colorectal cancer: a fluorescence in situ (FISH) and chromogenic in situ hybridization (CISH) analysis.
Epidermal growth factor receptor (EGFR) status and K-Ras mutations in colorectal cancer.
Epidermal growth factor receptor and K-RAS status in two cohorts of squamous cell carcinomas.
Epigenetic activation of the small GTPase TCL contributes to colorectal cancer cell migration and invasion.
Epiregulin gene expression as a biomarker of benefit from cetuximab in the treatment of advanced colorectal cancer.
Ethnic difference in the pattern of K-ras oncogene mutations in human colorectal cancers.
Evaluating the treatment of metastatic colorectal cancer with monoclonal antibodies.
Evaluation of K-RAS gene in colorectal cancer.
Exploring biomarkers in head and neck cancer.
Expression of chemokine receptor CCR5 correlates with the presence of hepatic molecular metastases in K-ras positive human colorectal cancer.
Expression of cytosolic and group X secretory phospholipase A(2) genes in human colorectal adenocarcinomas.
Expression of epiregulin and amphiregulin and K-ras mutation status predict disease control in metastatic colorectal cancer patients treated with cetuximab.
Extended staging results from the detection of isolated tumor cells in the liver of colorectal cancer patients.
Fabrication of DNA microarrays onto polymer substrates using UV modification protocols with integration into microfluidic platforms for the sensing of low-abundant DNA point mutations.
Factors influencing the detection of mutant K-ras in the serum of patients with colorectal cancer.
Fast simultaneous detection of K-RAS mutations in colorectal cancer.
Fat and K-ras mutations in sporadic colorectal cancer in The Netherlands Cohort Study.
Fecal multiple molecular tests to detect colorectal cancer in stool.
Frequency and clinico-pathological associations of ras mutations in colorectal cancer in the Victorian population.
Frequency and clinicopathology associations of K-ras mutations in colorectal cancer in a northeast Mexican population.
Frequency and spectrum of K-RAS codons 12 and 13 mutations in colorectal adenocarcinomas from Taiwan.
Frequency of K-RAS and N-RAS Gene Mutations in Colorectal Cancers in Southeastern Iran
Frequent and characteristic K-ras activation in aberrant crypt foci of colon. Is there preference among K-ras mutants for malignant progression?
Frequent detection of K-ras mutation in stool samples of colorectal carcinoma patients after improved DNA extraction: comparison with tissue samples.
Frequent hypermethylation of RASSF1A in early flat-type colorectal tumors.
Frequent involvement of ras-signalling pathways in both polypoid-type and flat-type early-stage colorectal cancers.
Frequent polymorphism of peroxisome proliferator activated receptor gamma gene in colorectal cancer containing wild-type K-ras gene.
Gene-environment interactions in the pre-Industrial Era: the cancer of King Ferrante I of Aragon (1431-1494).
Genetic abnormalities and microsatellite instability in colorectal cancer.
Genetic alterations in colorectal cancer, comparative analysis of deletion events, and point mutations.
Genetic alterations in ulcerative colitis-associated neoplasia focusing on APC, K-ras gene and microsatellite instability.
Genetic alterations of APC, K-ras, p53, MSI, and MAGE in Korean colorectal cancer patients.
Genetic alterations of K-ras may reflect prognosis in stage III colon cancer patients below 60 years of age.
Genetic analysis of colorectal cancer.
Genetic and biochemical changes in colorectal carcinoma in relation to morphologic characteristics.
Genetic changes in multi-step development of colorectal cancer.
Genetic detection of colorectal cancer cells in circulation and lymph nodes.
Genetic detection of lymph node micrometastases: a selection criterion for liver transplantation in patients with liver metastases after colorectal cancer.
Genetic diagnosis identifies occult lymph node metastases undetectable by the histopathological method.
Genetic diagnosis of lymph-node metastasis in colorectal cancer.
Genetic pathways and genome-wide determinants of clinical outcome in colorectal cancer.
Genetic pathways in the evolution of morphologically distinct colorectal neoplasms.
Genomic heterogeneity and instability in colorectal cancer: spectral karyotyping, glutathione transferase-Ml and ras.
Genotyping of K-ras codons 12 and 13 mutations in colorectal cancer by capillary electrophoresis.
Glutathione S-transferase-pi overexpression is closely associated with K-ras mutation during human colon carcinogenesis.
Greater frequency of K-ras Val-12 mutation in colorectal cancer as detected with sensitive methods.
H-RAS V12-induced radioresistance in HCT116 colon carcinoma cells is heregulin dependent.
Haploinsufficient tumor suppressor genes.
Hematologic toxicity assessment in solid tumor patients treated with cetuximab: A pooled analysis of 18 randomized controlled trials.
Heterogeneous distribution of K-ras mutations in primary colon carcinomas: implications for EGFR-directed therapy.
High frequency of activated K-ras codon 15 mutant in colorectal carcinomas from Taiwanese patients.
High frequency of K-ras mutations in sporadic colorectal adenomas.
High nuclear expression of phosphorylated extracellular signal-regulated kinase in tumor cells in colorectal glands is associated with poor outcome in colorectal cancer.
High Rab27A expression indicates favorable prognosis in CRC.
High sensitivity scanning of colorectal tumors and matched plasma DNA for mutations in APC, TP53, K-RAS, and BRAF genes with a novel DHPLC fluorescence detection platform.
High-content screening Raman spectroscopy (HCS-RS) of panitumumab-exposed colorectal cancer cells.
High-degree tumor budding and podia-formation in sporadic colorectal carcinomas with K-ras gene mutations.
HMGB1-RAGE signaling facilitates Ras-dependent Yap1 expression to drive colorectal cancer stemness and development.
Human Papillomavirus DNA and Oncogene Alterations in Colorectal Tumors.
Human urine contains small, 150 to 250 nucleotide-sized, soluble DNA derived from the circulation and may be useful in the detection of colorectal cancer.
Hypermethylation of CpG island in O6-methylguanine-DNA methyltransferase gene was associated with K-ras G to A mutation in colorectal tumor.
Identification of mutant K-Ras-dependent phenotypes using a panel of isogenic cell lines.
Identification of Rho GTPase Activating Protein 6 Isoform 1 Variant as a New Molecular Marker in Human Colorectal Tumors.
Identification of subjects at risk for colorectal carcinoma through a test based on K-ras determination in the stool.
Immunohistochemical assay for detection of K-ras protein expression in metastatic colorectal cancer.
Immunohistochemical studies of colorectal cancers that developed following pelvic irradiation.
Immunoperoxidase staining for cytokeratins 8 and 18 is very sensitive for detection of occult node metastasis of colorectal cancer: a comparison with genetic analysis of K-ras.
Impact of Cellular Genetic Make-up on Colorectal Cancer Cell Lines Response to Ellagic Acid: Implications of Small Interfering RNA.
Impact of oncogenes in tumor angiogenesis: mutant K-ras up-regulation of vascular endothelial growth factor/vascular permeability factor is necessary, but not sufficient for tumorigenicity of human colorectal carcinoma cells.
Implication of K-ras and p53 in colorectal cancer carcinogenesis in Tunisian population cohort.
Improving detection of colorectal cancer.
Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is associated with G to A mutations in K-ras in colorectal tumorigenesis.
Increase in the frequency of K-ras codon 12 point mutation in colorectal carcinoma in elderly males in Japan: the 1990s compared with the 1960s.
Increased expression of annexin A1 is correlated with K-ras mutation in colorectal cancer.
Increased farnesyltransferase activity in human colorectal cancer: relationship with clinicopathological features and K-ras mutation.
Individualization of therapy for colorectal cancer based on clinical and molecular parameters.
Induced Chromosomal Aneuploidy Results in Global and Consistent Deregulation of the Transcriptome of Cancer Cells.
Influence of age on adenomatous polyposis coli and p53 mutation frequency in sporadic colorectal cancer-rarity of co-occurrence of mutations in APC, K-ras, and p53 genes.
Influence of K-ras status and anti-tumour treatments on complications due to colorectal self-expandable metallic stents: A retrospective multicentre study.
Infrequent inactivation of DCC gene in replication error-positive colorectal cancers.
Infrequent K-ras activation in superficial-type (flat) colorectal adenomas and adenocarcinomas.
Inhibition of rat colon tumors by sulindac and sulindac sulfone is independent of K-ras (codon 12) mutation.
Initial Report of Phase II Study on Bi-weekly SOX plus Cetuximab Treatment for Wild-type K-RAS Advanced and Recurrent Colorectal Cancer.
Ink4a/Arf and oncogene-induced senescence prevent tumor progression during alternative colorectal tumorigenesis.
Insulin-like growth factor 1 expression correlates with clinical outcome in K-RAS wild type colorectal cancer patients treated with cetuximab and irinotecan.
Interlaboratory comparison of K-ras testing by real-time PCR and RFLP in colorectal cancer samples.
Involvement of Activated Cdc42 Kinase1 in Colitis and Colorectal Neoplasms.
Involvement of K-RAS mutations and amino acid substitutions in the survival of metastatic colorectal cancer patients.
Involvement of Kruppel-like factor 6 (KLF6) mutation in the development of nonpolypoid colorectal carcinoma.
Involvement of small ArfGAP1 (SMAP1), a novel Arf6-specific GTPase-activating protein, in microsatellite instability oncogenesis.
Is availability of anti-EGFR therapy for the colorectal adenocarcinomas showing fascin expression limited?
Is K-ras gene mutation a prognostic factor for colorectal cancer: a systematic review and meta-analysis.
Ischemia-induced K-ras mutations in human colorectal cancer cells: role of microenvironmental regulation of MSH2 expression.
K-ras 4A and 4B are co-expressed widely in human tissues, and their ratio is altered in sporadic colorectal cancer.
K-ras activation in colorectal tumors from patients with familial polyposis coli.
K-ras activation in gastric epithelial tumors in Japanese.
K-ras activation in neoplasms of the human female reproductive tract.
K-ras and B-raf gene mutations are not associated with gastrin- and CCK2-receptor mRNA expression in human colorectal tumour tissues.
K-ras and p16 aberrations confer poor prognosis in human colorectal cancer.
K-ras and p53 gene mutations in colorectal cancer in 57 Japanese patients.
K-ras and p53 mutations and overexpressions as prognostic factors in female rectal carcinoma.
K-ras and p53 mutations in colonic lavage fluid of patients with colorectal neoplasias.
K-ras and p53 mutations in DNA extracted from colonic epithelial cells exfoliated in faeces of patients with colorectal cancer.
K-ras and p53 mutations in hereditary non-polyposis colorectal cancers.
K-Ras and sensitivity to EGFR inhibitors in metastatic colorectal cancer.
K-ras Asp12 mutant neither interacts with Raf, nor signals through Erk and is less tumorigenic than K-ras Val12.
K-ras codon 12 and 13 mutations are correlated with differential patterns of tumor cell dissemination in colorectal cancer patients.
K-ras exon 4A has a tumour suppressor effect on carcinogen-induced murine colonic adenoma formation.
K-ras gene mutation as an early prognostic marker of colon cancer.
K-ras gene mutation in colorectal adenomas and carcinomas from familial adenomatous polyposis patients.
K-ras gene mutation is a useful predictor of the survival of early stage colorectal cancers.
K-Ras gene mutation status as a prognostic and predictive factor in patients with colorectal cancer undergoing irinotecan- or oxaliplatin-based chemotherapy.
K-ras gene mutation status in colorectal cancer: comparative analysis of pyrosequencing and PCR-RFLP.
K-ras gene mutations in adenomas and carcinomas of the colon.
K-ras gene mutations in early colorectal cancer ... flat elevated vs polyp-forming cancer....
K-ras gene mutations in normal colorectal tissues from K-ras mutation-positive colorectal cancer patients.
K-ras genetic mutation and influencing factor analysis for Han and Uygur nationality colorectal cancer patients.
K-ras mutation and loss of heterozygosity of chromosome 17p and survival in colorectal cancer.
K-Ras mutation and prognosis of colorectal cancer: a meta-analysis.
K-ras mutation detection in colorectal cancer using the Pyrosequencing technique.
K-ras Mutation in Colorectal Cancer, A Report from Southern Iran.
K-ras mutation in colorectal cancer: relations to patient age, sex and tumour location.
K-ras mutation in colorectal carcinomas from singapore.
K-RAS mutation profile in Puerto Rican patients with colorectal cancer: trends from April 2009 to January 2011.
K-Ras mutation status as a predictive biomarker in metastatic colorectal cancer.
K-ras mutation status correlates with the expression of VEGFR1, VEGFR2, and PDGFRalpha in colorectal cancer.
K-ras mutation: early detection in molecular diagnosis and risk assessment of colorectal, pancreas, and lung cancers--a review.
K-ras mutational analysis of polyclonal colorectal cancers identifies uniclonal circulating tumor cells.
K-ras mutations (codon 12) are not involved in down-regulation of MHC class-I genes in colon carcinomas.
K-ras mutations and benefit from cetuximab in advanced colorectal cancer.
K-ras mutations and cetuximab in colorectal cancer.
K-ras mutations and p53 alterations in neoplastic and nonneoplastic lesions associated with longstanding ulcerative colitis.
K-ras mutations and RASSF1A promoter methylation in colorectal cancer.
K-Ras mutations and treatment outcome in colorectal cancer patients receiving exclusive fluoropyrimidine therapy.
K-Ras mutations are changing practice in advanced colorectal cancer.
K-ras mutations are correlated to lymph node metastasis and tumor stage, but not to the growth pattern of colon carcinoma.
K-ras mutations are found in DNA extracted from the plasma of patients with colorectal cancer.
K-ras Mutations as the Earliest Driving Force in a Subset of Colorectal Carcinomas.
K-ras mutations in colorectal cancer: a practice changing discovery.
K-ras mutations in incident sporadic colorectal adenomas.
K-Ras Mutations in Non-Small-Cell Lung Cancer: Prognostic and Predictive Value.
K-ras mutations in patients with early colorectal cancers.
K-ras mutations in sera of patients with colorectal neoplasias and long-standing inflammatory bowel disease.
K-ras mutations in sporadic colorectal tumors in Israel: unusual high frequency of codon 13 mutations and evidence for nonhomogeneous representation of mutation subtypes.
K-ras mutations, rectal crypt cells proliferation, and meat consumption in patients with left-sided colorectal carcinoma.
K-ras oncogene mutations in sporadic colorectal cancer in The Netherlands Cohort Study.
K-ras point mutations in human colorectal carcinomas: relation to aneuploidy and metastasis.
K-ras status does not predict successful hepatic resection of colorectal cancer metastasis.
Keratin 20 is a specific marker of submicroscopic lymph node metastases in colorectal cancer: validation by K-RAS mutations.
KLF5 mediates the hyper-proliferative phenotype of the intestinal epithelium in mice with intestine-specific endogenous K-RasG12D expression.
Kruppel-like factor 6 (KLF6) is a tumor-suppressor gene frequently inactivated in colorectal cancer.
KY1022, a small molecule destabilizing Ras via targeting the Wnt/?-catenin pathway, inhibits development of metastatic colorectal cancer.
Laser pressure catapulting (LPC): optimization LPC-system and genotyping of colorectal carcinomas.
Ligase detection reaction for the analysis of point mutations using free-solution conjugate electrophoresis in a polymer microfluidic device.
Long noncoding RNA UCA1 enhances sensitivity to oncolytic vaccinia virus by sponging miR-18a/miR-182 and modulating the Cdc42/filopodia axis in colorectal cancer.
Loss of Apc allows phenotypic manifestation of the transforming properties of an endogenous K-ras oncogene in vivo.
Loss of CDX2 expression and microsatellite instability are prominent features of large cell minimally differentiated carcinomas of the colon.
Loss of heterozygosity at the human RAP1A/Krev-1 locus is a rare event in colorectal tumors.
Loss of RASSF1A expression in colorectal cancer and its association with K-ras status.
Low Gene Dosage of Cdc42 Is Not Associated with Protein Dysfunction in Patients with Colorectal Cancer.
Low O6-alkylguanine DNA-alkyltransferase activity in normal colorectal tissue is associated with colorectal tumours containing a GC-->AT transition in the K-ras oncogene.
Low somatic K-ras mutation frequency in colorectal cancer diagnosed under the age of 45 years.
Low-dose metronomic cyclophosphamide treatment mediates ischemia-dependent K-ras mutation in colorectal carcinoma xenografts.
Macrophages stimulate gastric and colorectal cancer invasion through EGFR Y(1086), c-Src, Erk1/2 and Akt phosphorylation and smallGTPase activity.
Malignant transformation of rat embryo fibroblasts by cotransfection with eleven human mutant p53 cDNAs and activated H-ras gene.
MEK1/2 inhibitors AS703026 and AZD6244 may be potential therapies for KRAS mutated colorectal cancer that is resistant to EGFR monoclonal antibody therapy.
Melting temperature analysis as quantitative method for detection of point mutations.
Metastatic colorectal cancer first-line treatment with bevacizumab: the impact of K-ras mutation.
Methylation of estrogen receptor 1 in colorectal adenomas is not age-dependent, but is correlated with K-ras mutation.
Methylation of O-6-methylguanine DNA methyltransferase characterizes a subset of colorectal cancer with low-level DNA microsatellite instability.
MicroRNA-100 regulates SW620 colorectal cancer cell proliferation and invasion by targeting RAP1B.
MicroRNA-101 suppresses colorectal cancer progression by negative regulation of Rap1b.
MicroRNA-224 suppresses colorectal cancer cell migration by targeting Cdc42.
MicroRNA-30b-5p functions as a metastasis suppressor in colorectal cancer by targeting Rap1b.
MicroRNAs targeting mutant K-ras by electrotransfer inhibit human colorectal adenocarcinoma cell growth in vitro and in vivo.
Microsatellite instability in colorectal adenocarcinoma cell lines that have full-length adenomatous polyposis coli protein.
miR-137 targets Cdc42 expression, induces cell cycle G1 arrest and inhibits invasion in colorectal cancer cells.
miR-185 targets RhoA and Cdc42 expression and inhibits the proliferation potential of human colorectal cells.
miR-18a inhibits CDC42 and plays a tumour suppressor role in colorectal cancer cells.
miR-211 regulates the expression of RRM2 in tumoral metastasis and recurrence in colorectal cancer patients with a k-ras gene mutation.
miR-330 regulates the proliferation of colorectal cancer cells by targeting Cdc42.
MiR-384 inhibits human colorectal cancer metastasis by targeting KRAS and CDC42.
MiR-622 inhibited colorectal cancer occurrence and metastasis by suppressing K-Ras.
Modified mismatch polymerase chain reaction-restriction fragment length polymorphism detected mutations in codon 12 and 13 of exon 2 of K-
Molecular approaches for colorectal cancer screening.
Molecular characteristics of poorly differentiated adenocarcinoma and signet-ring-cell carcinoma of colorectum.
Molecular detection (k-ras) of exfoliated tumour cells in the pelvis is a prognostic factor after resection of rectal cancer?
Molecular detection of codon 12 K-RAS mutations in circulating DNA from serum of colorectal cancer patients.
Molecular detection of genetic alterations in the serum of colorectal cancer patients.
Molecular epidemiology of colon cancer.
Molecular genetic profiles of colitis-associated neoplasms.
Molecular mechanisms underlying the tumorigenesis of colorectal adenomas: correlation to activated K-ras oncogene.
Molecular profiling of sporadic colorectal tumors by microsatellite analysis.
Molecular staging of colorectal cancer: K-ras mutation analysis of lymph nodes upstages Dukes B patients.
Morphological and molecular heterogeneity in colorectal neoplasms with K-RAS mutation. A report of two cases.
mTOR-independent 4E-BP1 phosphorylation is associated with cancer resistance to mTOR kinase inhibitors.
Multiple detection of genetic alterations in tumors and stool.
Multiplex PCR/LDR for detection of K-ras mutations in primary colon tumors.
Murine models of colorectal cancer: studying the role of oncogenic K-ras.
Mutant K-Ras activation of the proapoptotic MST2 pathway is antagonized by wild-type K-Ras.
Mutant K-ras in apparently normal mucosa of colorectal cancer patients. Its potential as a biomarker of colorectal tumorigenesis.
Mutant K-ras promotes carcinogen-induced murine colorectal tumourigenesis, but does not alter tumour chromosome stability.
Mutant K-ras regulates cathepsin B localization on the surface of human colorectal carcinoma cells.
Mutant-enriched PCR and allele-specific hybridization reaction to detect K-ras mutations in stool DNA: high prevalence in a large sample of older adults.
Mutation analysis of p53, K-ras, and BRAF genes in colorectal cancer progression.
Mutation in the K-ras gene at codon 12 does not correlate with disease progression in colorectal carcinoma patients treated with 5-FU/folinic acid biomodulated chemotherapy.
Mutation of beta-catenin does not coexist with K-ras mutation in colorectal tumorigenesis.
Mutation pattern of K-ras gene in colorectal cancer patients of Kashmir: a report.
Mutation status of genes encoding RhoA, Rac1, and Cdc42 GTPases in a panel of invasive human colorectal and breast tumors.
Mutations in APC, CTNNB1 and K-ras genes and expression of hMLH1 in sporadic colorectal carcinomas from the Netherlands Cohort Study.
Mutations in codons 12 and 13 of K-ras exon 2 in colorectal tumors of Saudi Arabian patients: frequency, clincopathological associations, and clinical outcomes.
Mutations in epidermal growth factor receptor and K-ras in Chinese patients with colorectal cancer.
Mutations in K-ras and Epidermal Growth Factor Receptor Expression in Korean Patients With Stages III and IV Colorectal Cancer.
Mutations of p53 and K-ras correlate TF expression in human colorectal carcinomas: TF downregulation as a marker of poor prognosis.
MUTYH exon 7 and 13 mutations associated with colorectal cancer (MAP syndrome) are not commonly associated with sporadic pancreatic cancer.
MYC-nick promotes cell migration by inducing fascin expression and Cdc42 activation.
NAD(P)H:quinone oxidoreductase-dependent risk for colorectal cancer and its association with the presence of K-ras mutations in tumors.
NAT2 fast acetylator genotype and MGMT promoter methylation may contribute to gender difference in K-RAS mutation occurrence in Taiwanese colorectal cancer.
Natural history of colorectal nonpolypoid adenomas: a prospective colonoscopic study and relation with cell kinetics and K-ras mutations.
NDRG1 regulates Filopodia-induced Colorectal Cancer invasiveness via modulating CDC42 activity.
No major difference in K-ras and p53 abnormalities in sporadic and hereditary nonpolyposis colorectal adenomas.
No-touch isolation technique reduces intraoperative shedding of tumor cells into the portal vein during resection of colorectal cancer.
Noninvasive detection through REMS-PCR technique of K-ras mutations in stool DNA of patients with colorectal cancer.
Not infrequent K-ras mutations in depressed-type early colorectal carcinomas larger than 10 mm.
Novel approach to abuse the hyperactive K-Ras pathway for adenoviral gene therapy of colorectal cancer.
Nuclear beta-catenin expression is closely related to ulcerative growth of colorectal carcinoma.
O(6)-methylguanine methyltransferase in colorectal cancers: detection of mutations, loss of expression, and weak association with G:C>A:T transitions.
O(6)-Methylguanine-DNA methyltransferase promoter hypermethylation shifts the p53 mutational spectrum in non-small cell lung cancer.
O6-methylguanine-DNA methyltransferase Leu84Phe and Ile143Val polymorphisms and risk of colorectal cancer in the Nurses' Health Study and Physicians' Health Study (United States).
Oligonucleotide microarray analysis of distinct gene expression patterns in colorectal cancer tissues harboring BRAF and K-ras mutations.
Oligonucleotide microarray-based mutation detection of the K-ras gene in colorectal cancers with use of competitive DNA hybridization.
Oncogenic events regulate tissue factor expression in colorectal cancer cells: implications for tumor progression and angiogenesis.
Oncogenic K-ras activates p38 to maintain colorectal cancer cell proliferation during MEK inhibition.
Oncogenic K-Ras signals through epidermal growth factor receptor and wild-type H-Ras to promote radiation survival in pancreatic and colorectal carcinoma cells.
Oncogenic K-Ras suppresses IP3-dependent Ca2+ release through remodelling of the isoform composition of IP3Rs and ER luminal Ca2+ levels in colorectal cancer cell lines.
Oncogenic K-Ras Turns Death Receptors Into Metastasis-Promoting Receptors in Human and Mouse Colorectal Cancer Cells.
Oncogenic Ras mutant causes the hyperactivation of NF-?B via acceleration of its transcriptional activation.
Oncogenic Ras promotes butyrate-induced apoptosis through inhibition of gelsolin expression.
Oncogenic Ras triggers hyperproliferation and impairs polarized colonic morphogenesis by autocrine ErbB3 signaling.
Oncogenic RAS-induced downregulation of ATG12 is required for survival of malignant intestinal epithelial cells.
Oncosuppressor methylation: A possible key role in colon metastatic progression.
Oncosuppressor methylation: a possible key role in colon metastatic progression.
Orthotopic xenografts of human pancreatic carcinomas acquire genetic aberrations during dissemination in nude mice.
Overexpression of Rab1B and MMP9 predicts poor survival and good response to chemotherapy in patients with colorectal cancer.
P14 methylation in human colon cancer is associated with microsatellite instability and wild-type p53.
p53 and K-ras gene mutations correlate with tumor aggressiveness but are not of routine prognostic value in colorectal cancer.
p53 and Ki-ras as prognostic factors for Dukes' stage B colorectal cancer.
p53 is an independent pre-treatment markers for long-term survival in stage II and III colorectal cancers: an analysis of interaction between genetic markers and fluorouracil-based adjuvant therapy.
P53 mutations in colorectal cancer from northern Iran: Relationships with site of tumor origin, microsatellite instability and K-ras mutations.
p53 Overexpression and K-ras Codon 12 Mutations in Submucosal Invasive Colorectal Cancer.
p53 overexpression and K-ras codon 12 mutations in submucosal invasive depressed-type colorectal cancer.
p73 Isoforms affect VEGF, VEGF165b and PEDF expression in human colorectal tumors: VEGF165b downregulation as a marker of poor prognosis.
Panitumumab and irinotecan every 3 weeks is an active and convenient regimen for second-line treatment of patients with wild-type K-RAS metastatic colorectal cancer.
Pathogenesis of colorectal carcinoma and therapeutic implications: the roles of the ubiquitin-proteasome system and Cox-2.
Pattern of growth factor, proto-oncogene and carcinoembryonic antigen gene expression in human colorectal carcinoma cell lines.
Patterns of K-ras mutation in colorectal carcinomas from Iran and Italy (a Gruppo Oncologico dell'Italia Meridionale study): influence of microsatellite instability status and country of origin.
Peptide nucleic acid clamp PCR: a novel K-ras mutation detection assay for colorectal cancer micrometastases in lymph nodes.
Peptidomimetic inhibitors of APC-Asef interaction block colorectal cancer migration.
Peroxisome proliferator-activated receptor gamma and spermidine/spermine N1-acetyltransferase gene expressions are significantly correlated in human colorectal cancer.
Persistence of K-ras mutations in plasma after colorectal tumor resection.
Personalized medicine and oncology practice guidelines: a case study of contemporary biomarkers in colorectal cancer.
Peutz-Jeghers polyps, dysplasia, and K-ras codon 12 mutations.
Phase II study of selumetinib (AZD6244, ARRY-142886) plus irinotecan as second-line therapy in patients with K-RAS mutated colorectal cancer.
Phase III randomized, placebo-controlled study of cetuximab plus brivanib alaninate versus cetuximab plus placebo in patients with metastatic, chemotherapy-refractory, wild-type K-RAS colorectal carcinoma: the NCIC Clinical Trials Group and AGITG CO.20 Trial.
PIK3CA mutation is predictive of poor survival in patients with colorectal cancer.
PIK3CA, BRAF, and PTEN status and benefit from cetuximab in the treatment of advanced colorectal cancer--results from NCIC CTG/AGITG CO.17.
Polyamine biosynthesis in relation to K-ras and p-53 mutations in colorectal carcinoma.
Polymorphisms in cyclooxygenase-2 and epidermal growth factor receptor are associated with progression-free survival independent of K-ras in metastatic colorectal cancer patients treated with single-agent cetuximab.
Polypoid growth and K-ras codon 12 mutation in colorectal cancer.
Post-transcriptional regulation of the tumor suppressor miR-139-5p and a network of miR-139-5p-mediated mRNA interactions in colorectal cancer.
Predictive and prognostic biomarkers with therapeutic targets in breast, colorectal, and non-small cell lung cancers: A systemic review of current development, evidence, and recommendation.
Predominance of G to A codon 12 mutation K-ras gene in Dukes' B colorectal cancer.
Presence of activated ras correlates with increased cysteine proteinase activities in human colorectal carcinomas.
Prevalence of G-to-T transversions among K-ras oncogene mutations in human colorectal tumors in Yugoslavia.
Prevalence of p53 overexpression or mutations, but not k-ras mutations, in recurrent patients affected by colorectal-carcinoma.
Prognostic and predictive value of K-RAS mutations in non-small cell lung cancer.
Prognostic factors of colorectal cancer: K-ras mutation, overexpression of the p53 protein, and cell proliferative activity.
Prognostic impact of K-RAS mutational status and primary tumor location in patients undergoing resection for colorectal cancer liver metastases: an update.
Prognostic impact of K-RAS mutational status and primary tumour location in patients undergoing resection for colorectal cancer liver metastases: A METHEPAR analysis (multicentre study in Argentina).
Prognostic importance of tumor location and anti-EGFR therapy in patients with K-RAS wild type metastatic colorectal cancer.
Prognostic molecular markers for planning adjuvant chemotherapy trials in Dukes' B colorectal cancer patients: how much evidence is enough?
Prognostic significance of DNA aneuploidy and p21 ras oncoprotein expression in colorectal cancer and their role in the determination of treatment modalities.
Prognostic significance of K-ras and TP53 mutations in the role of adjuvant chemotherapy on survival in patients with Dukes C colon cancer.
Prognostic significance of K-Ras mutation rate in metastatic colorectal cancer patients.
Prognostic significance of K-ras mutations in colorectal carcinoma.
Prognostic value of disseminated colorectal tumor cells in the liver: results of follow-up examinations.
Prognostic value of K-ras mutations and allelic imbalance on chromosome 18q in patients with resected colorectal cancer.
Promoter hypermethylation of the DNA repair gene O(6)-methylguanine-DNA methyltransferase is associated with the presence of G:C to A:T transition mutations in p53 in human colorectal tumorigenesis.
Prospective study of a molecular selection profile for RAS wild type colorectal cancer patients receiving irinotecan-cetuximab.
Protein expression of NF-kappaB in human colorectal adenocarcinoma.
PTEN loss of expression predicts cetuximab efficacy in metastatic colorectal cancer patients.
Putative precursor cancer cells in human colorectal cancer tissue.
Quality of life in patients with K-RAS wild-type colorectal cancer: the CO.20 phase 3 randomized trial.
Quantitative and qualitative characterization of plasma DNA identifies primary and recurrent colorectal cancer.
Quantitative detection of mutant alleles of the K-ras gene with minor groove binder-conjugated fluorogenic DNA probes.
Rab GTPase Mediating Regulation of NALP3 in Colorectal Cancer.
Rab11 collaborates E-cadherin to promote collective cell migration and indicates a poor prognosis in colorectal carcinoma.
Rab11 regulates E-cadherin expression and induces cell transformation in colorectal carcinoma.
Rab13 regulates sEV secretion in mutant KRAS colorectal cancer cells.
Rab23 contributes to the progression of colorectal cancer via protein kinase B and extracellular signal-regulated kinase signaling pathways.
Rab27b is a potential predictor for metastasis and prognosis in colorectal cancer.
RAB27B-activated secretion of stem-like tumor exosomes delivers the biomarker microRNA-146a-5p, which promotes tumorigenesis and associates with an immunosuppressive tumor microenvironment in colorectal cancer.
Rac1 GTPase and the Rac1 exchange factor Tiam1 associate with Wnt-responsive promoters to enhance beta-catenin/TCF-dependent transcription in colorectal cancer cells.
Rac1B overexpression in Papillary Thyroid Carcinoma: a role to unravel.
Radiation-stimulated ERK1/2 and JNK1/2 signaling can promote cell cycle progression in human colon cancer cells.
Rapid detection of low-abundance K-ras mutation in stools of colorectal cancer patients using chip-based temperature gradient capillary electrophoresis.
ras and human tumors.
Ras inhibitors display an anti-metastatic effect by downregulation of lysyl oxidase through inhibition of the Ras-PI3K-Akt-HIF-1? pathway.
Ras oncogene and p53 gene hotspot mutations in colorectal cancers.
Rational Fabrication of a Smart Electrochemiluminescent Sensor: Synergistic Effect of a Self-Luminous Faraday Cage and Biomimetic Magnetic Vesicles.
Re. article entitled 'Keratin 20 is a specific marker of submicroscopic lymph node metastases in colorectal cancer: validation by K-RAS mutations'.
Recycling Endosomes in Mature Epithelia Restrain Tumorigenic Signaling.
Reduced MGMT activity in human colorectal adenomas is associated with K-ras GC->AT transition mutations in a population exposed to methylating agents.
Regulation of cyclooxygenase-2 expression by the Wnt and ras pathways.
Regulation of RAP1B by miR-139 suppresses human colorectal carcinoma cell proliferation.
Regulation of the small GTPase Ran by miR-802 modulates proliferation and metastasis in colorectal cancer cells.
Relation between the occurrence of K-ras gene point mutations and genotypes of polymorphic N-acetyltransferase in human colorectal carcinomas.
Relationship Between Expression of ras p21 Oncoprotein and Mutation Status of the K-ras Gene in Sporadic Colorectal Cancer Patients in Tunisia.
Relationship between overexpression of ras p21 oncoprotein and K-ras codon 12 and 13 mutations in Turkish colorectal cancer patients.
Relationship of BRAF mutation, morphology, and apoptosis in early colorectal cancer.
Release of autoinhibition of ASEF by APC leads to CDC42 activation and tumor suppression.
Reliability of K-ras mutational analysis on cytological samples from metastatic colorectal cancer.
Removal of high-molecular-weight DNA by carboxylated magnetic beads enhances the detection of mutated K-ras DNA in urine.
Renaissance mummies in Italy.
Resistance to EGF-R (erbB-1) and VEGF-R modulating agents.
Restriction endonuclease-mediated selective polymerase chain reaction: a novel assay for the detection of K-ras mutations in clinical samples.
Rho GTPase signaling in the development of colorectal cancer.
RHOA inactivation enhances Wnt signalling and promotes colorectal cancer.
Role of ?4 integrin in HER-3-negative, K-RAS wild-type metastatic colorectal tumors receiving cetuximab.
Role of K-ras mutations in colorectal carcinoma.
Role of retinoids in the prevention and treatment of colorectal cancer.
Sampling technique influences the detection of K-ras mutations in normal appearing mucosa of colorectal cancer patients.
Sensitive detection of K-ras mutations augments diagnosis of colorectal cancer metastases in the liver.
Sequence of molecular genetic events in colorectal tumorigenesis.
Silencing the wild-type and mutant K-ras increases the resistance to 5-flurouracil in HCT-116 as a colorectal cancer cell line.
Simplified rapid non-radioactive PCR-SSCP method applied to K-ras mutation analysis.
Simultaneous mutations in K-ras and TP53 are indicative of poor prognosis in sporadic colorectal cancer.
Small Molecule Destabilizer of ?-Catenin and Ras Proteins Antagonizes Growth of K-Ras Mutation-Driven Colorectal Cancers Resistant to EGFR Inhibitors.
Somatic mutation screening: identification of individuals harboring K-ras mutations with the use of plasma DNA.
Somatic mutations of ERBB2 kinase domain in gastric, colorectal, and breast carcinomas.
Somatic Mutations of K-Ras and BRAF in Thai Colorectal Cancer and their Prognostic Value.
Somatic mutations, acetylator status, and prognosis in colorectal cancer.
Sotorasib: First Approval.
Specific c-K-ras gene mutations as a tumor-response marker in locally advanced rectal cancer treated with preoperative chemoradiotherapy.
Specific codon 13 K-ras mutations are predictive of clinical outcome in colorectal cancer patients, whereas codon 12 K-ras mutations are associated with mucinous histotype.
Splice isoforms as therapeutic targets for colorectal cancer.
Stability of K-ras mutations throughout the natural history of human colorectal cancer.
Statistical strategies to improve the efficiency of molecular studies of colorectal cancer prognosis.
Suppression of colorectal cancer growth using an adenovirus vector expressing an antisense K-ras RNA.
Synchronous colorectal cancer: clinical, pathological and molecular implications.
Systemic inflammatory status predict the outcome of k-RAS WT metastatic colorectal cancer patients receiving the thymidylate synthase poly-epitope-peptide anticancer vaccine.
TAp73 is one of the genes responsible for the lack of response to chemotherapy depending on B-Raf mutational status.
Targeted deletion of miR-139-5p activates MAPK, NF-?B and STAT3 signaling and promotes intestinal inflammation and colorectal cancer.
Targeting inhibition of K-ras enhances Ad.mda-7-induced growth suppression and apoptosis in mutant K-ras colorectal cancer cells.
Targeting the Wnt Pathway and Cancer Stem Cells with Anti-progastrin Humanized Antibodies as a Potential Treatment for K-RAS-Mutated Colorectal Cancer.
Tegafur gimeracil oter combined with oxaliplatin for advanced colorectal cancer.
Telomeric repeat-length alterations in colorectal carcinoma are associated with loss of heterozygosity and point mutation in p53 gene.
Tetrac and NDAT Induce Anti-proliferation via Integrin ?v?3 in Colorectal Cancers With Different K-RAS Status.
TGF-? acts as a dual regulator of COX-2/PGE2 tumor promotion depending of its cross-interaction with H-Ras and Wnt/?-catenin pathways in colorectal cancer cells.
The balanced induction of K-ras codon 12 and 13 mutations in mucosa differs from their ratio in neoplastic tissues.
The clinical benefit of bevacizumab in metastatic colorectal cancer is independent of K-ras mutation status: analysis of a phase III study of bevacizumab with chemotherapy in previously untreated metastatic colorectal cancer.
The combination of tetraiodothyroacetic acid and cetuximab inhibits cell proliferation in colorectal cancers with different K-ras status.
The detection of K-ras mutations in colorectal cancer using the amplification-refractory mutation system.
The differential effects of wildtype and mutated K-Ras on MST2 signalling are determined by K-Ras activation kinetics.
The differentially mutational spectra of the APC, K-ras, and p53 genes in sporadic colorectal cancers from Taiwanese patients.
The frequency and spectrum of K-ras mutations among Iraqi patients with sporadic colorectal carcinoma.
The Frequency and Type of K-RAS Mutations in Mexican Patients With Colorectal Cancer: A National Study.
The Presence of Mutations in the K-RAS Gene Does Not Affect Survival after Resection of Pulmonary Metastases from Colorectal Cancer.
The prognostic significance of K-ras, p53, and APC mutations in colorectal carcinoma.
The prognostic value of c-Kit, K-ras codon 12, and p53 codon 72 mutations in Egyptian patients with stage II colorectal cancer.
The prognostic value of the presence of mutations at the codons 12, 13, 61 of K-ras oncogene in colorectal cancer.
The role of antiangiogenic agents in the treatment of patients with advanced colorectal cancer according to K-RAS status.
The role of HER-3 expression in the prediction of clinical outcome for advanced colorectal cancer patients receiving irinotecan and cetuximab.
The role of K-RAS and B-RAF mutations as biomarkers in metastatic colorectal cancer.
The role of miRNA -31-3p and miR-31-5p in the anti-EGFR treatment efficacy of wild-type K-RAS metastatic colorectal cancer. Is it really the next best thing in miRNAs?
The role of miRNAs targeting K-ras and APC genes in colorectal cancer.
The type of K-ras mutation determines prognosis in colorectal cancer.
Therapeutic modulation of k-ras signaling in colorectal cancer.
Three-dimensional microarray compared with PCR-single-strand conformation polymorphism analysis/DNA sequencing for mutation analysis of K-ras codons 12 and 13.
Tissue sampling for mutation analysis in colorectal cancer: K-ras is homogeneously distributed throughout the tumor tissue.
Tn antigen promotes human colorectal cancer metastasis via H-Ras mediated epithelial-mesenchymal transition activation.
TNMF versus TNM in staging of colorectal cancer.
TP53 and let-7a micro-RNA regulate K-Ras activity in HCT116 colorectal cancer cells.
Transrenal DNA as a diagnostic tool: important technical notes.
Tumor budding predicts response to anti-EGFR therapies in metastatic colorectal cancer patients.
Tumor location and detection of k-ras mutations in stool from colorectal cancer patients.
Tumor markers in colorectal cancer, gastric cancer and gastrointestinal stromal cancers: European group on tumor markers 2014 guidelines update.
Tumour cell responses to MEK1/2 inhibitors: acquired resistance and pathway remodelling.
Tumour diagnosis by PCR-based detection of tumour cells.
Tumour genetics and genomics to personalise cancer treatment.
Tumour-derived mutated K-ras codon 12 expression in regional lymph nodes of stage II colorectal cancer patients is not associated with increased risk of cancer-related death.
Understanding the predictive role of K-ras for epidermal growth factor receptor-targeted therapies in colorectal cancer.
Upregulation of miR-582-5p inhibits cell proliferation, cell cycle progression and invasion by targeting Rab27a in human colorectal carcinoma.
Upregulation of non-mutated H-ras and its upstream and downstream signaling proteins in colorectal cancer.
Use of K-Ras as a predictive biomarker for selecting anti-EGF receptor/pathway treatment.
Use of molecular markers for predicting therapy response in cancer patients.
Utilization of K-ras mutations identified in stool DNA for the early detection of colorectal cancer.
Variation in K-ras codon 12 point mutation rate with histological atypia within individual colorectal tumors.
Whole-Exome Sequencing Analyses of Inflammatory Bowel Disease-Associated Colorectal Cancers.
Wild-type K-ras has a tumour suppressor effect on carcinogen-induced murine colorectal adenoma formation.
["Field cancerization"--an additional phenomenon in development of colon tumors? K-ras codon 12 mutations in normal colonic mucosa of patients with colorectal neoplasms]
[A Case of Rectal Cancer with Unresectable Liver Metastasis Responding to Rechallenge with FOLFIRI].
[A case of remnant liver metastases after resection of liver metastases from rectal cancer following treatment with 5-FU, L-OHP and CPT-11, with markedly effective treatment by cetuximab plus S-1].
[A study on the mutation of P53 and K-ras gene in colorectal adenomas and colorectal carcinomas].
[Age-related and clinical-pathogenetic features of colorectal cancer associated with status of K-ras gene].
[Analysis of therapeutic effect and prognosis in patients with metastatic colorectal cancer and different K-ras status].
[Association between H-ras and L-myc gene polymorphisms and susceptibility to colorectal cancer].
[Association of mutations of K-RAS oncogene and deletions of 18Q with lymph node metastasis of colorectal cancer]
[Cell kinetics of colorectal tumors with assessment by K-ras mutation and PCNA labeling index]
[Clinical outcomes in refractory colorectal cancer patients with wild-type K-ras treated with bevacizumab and oxaliplatin-based chemotherapy as a first-line treatment].
[Clinical relevance of the K-ras oncogene in colorectal cancer: experience in a Mexican population].
[Clinicopathological characteristics, MSI and K-ras gene mutations of double primary malignancies associated with colorectal cancer].
[Colorectal carcinoma--molecular markers in clinical routine]
[Correlation analysis between abundance of K-ras mutation in plasma free DNA and its correlation with clinical outcome and prognosis in patients with metastatic colorectal cancer].
[Correlation of K-ras Gene Mutations with the Protein Expressions of TAK1 and MAP4K2 in Colorectal Cancer].
[Current medicinal treatment of metastasized colorectal carcinoma].
[Cytomolecular aspects of colorectal carcinoma]
[Detection of genetic mutations in clinical specimens from cancer patients: comparison of NIRCA and SSCP scanning methods]
[Detection of K-ras mutations in colon cancer by PHA-PHFA (preferential homoduplex formation assay)]
[Detection of K-ras point mutations in the stool of patients with colorectal tumors]
[Determination of K-ras gene mutation in colorectal cancer tissue by capillary electrophoresis].
[Effect of microRNA143 expression on cell proliferation in colorectal carcinoma]
[Effect of shRNA-mediated CDC42 knockdown on morphology of colorectal cancer cells in vitro].
[Efficacy and safety of panitumumab for K-ras wild-type unresectable or recurrent colorectal cancer - a study focusing on first-line treatment].
[Efficacy of cetuximab combined with chemotherapy for patients with advanced colorectal cancer and unclear K-ras status].
[Frequency and clinicopathological associations of K-ras mutations in Venezuelan patients with colo-rectal cancer]
[Genes, heredity and colorectal cancer]
[Identification of K-RAS mutations in colorectal cancer patients in Israel].
[Immunohistological study for the ras oncogene products in colorectal cancer]
[K-ras gene mutation in colorectal cancer and its clinicopathologic significance].
[K-ras mutation and liver micrometastasis in colorectal cancer]
[K-ras mutation as a prognostic factor in colorectal carcinoma]
[Molecular-genetic analysis of clonal intratumoral heterogeneity on colorectal adenocarcinomas]
[Mutation analysis of K-ras protooncogene in colorectal adenocarcinomas and polyps in Russian patients]
[Mutations of APC and K-ras gene in aberrant crypt foci from human colon]
[Outcomes of patients with small bowel carcinoma treated with appropriate chemotherapy selected on the basis of genetic analysis findings].
[Personalized medicine--the future is already here].
[Pharmacoeconomics of molecular target drug: K-ras testing and cetuximab for colorectal cancer as an example].
[Polymerase chain reaction--principles and clinical relevance]
[Prevalence of K-ras gene mutations in human colorectal cancers]
[Prognostic value of K-ras gene mutation in colorectal cancer]
[Prognostic value of the presence of the mutation of the codons 12, 13 and 61 in K-ras oncogene in colorectal cancer]
[Proteome study of colorectal cancer genesis and hepatic metastasis]
[Sensitive detection of K-ras oncogene codon 12 mutations by nested PCR using mismatched primers and selective digestion of non-mutated PCR fragments with restriction enzyme]
[Significance of K-ras detection in colorectal cancer]
[Study of angiogenesis in human colorectal carcinoma and its modulation by p53 and K-ras gene]
[Study on relationship of the K-ras mutation with the occurrence of colorectal liver metastasis and survival outcomes].
[The Aragonese mummies of the Basilica of Saint Domenico Maggiore in Naples]
[The molecular screening of the stool for the colorectal carcinoma]
[The RAS paradoxon of the EGFR-targeted therapy of colorectal cancer]
[Two cases of metastatic colorectal cancer in wild-type K-RAS effectively treated by panitumumab].
[Value of fecal and blood adenomatous polyposis coli gene and K-ras gene mutation detection in colorectal neoplasm screening]
Colorectal Neoplasms, Hereditary Nonpolyposis
Hyperprogressive Disease in an Advanced Stage Colon Cancer Patient on Pembrolizumab: A Case Report.
No major difference in K-ras and p53 abnormalities in sporadic and hereditary nonpolyposis colorectal adenomas.
Tumor markers in colorectal cancer, gastric cancer and gastrointestinal stromal cancers: European group on tumor markers 2014 guidelines update.
Communicable Diseases
Bacterial virulence factors targeting Rho GTPases: parasitism or symbiosis?
Cone-Rod Dystrophies
Mutations in RAB28, encoding a farnesylated small GTPase, are associated with autosomal-recessive cone-rod dystrophy.
Whole-Organism Developmental Expression Profiling Identifies RAB-28 as a Novel Ciliary GTPase Associated with the BBSome and Intraflagellar Transport.
Confusion
Zonula occludens-2 regulates Rho proteins activity and the development of epithelial cytoarchitecture and barrier function.
Congenital Abnormalities
Cdc42 regulates cranial suture morphogenesis and ossification.
Genetic abnormalities involved in the pathogenesis of gallbladder carcinoma.
Inactivation of Cdc42 in neural crest cells causes craniofacial and cardiovascular morphogenesis defects.
Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Germline expression of H-Ras causes neurological deficits associated to Costello syndrome.
The role of p19 and p21 H-Ras proteins and mutants in miRNA expression in cancer and a Costello syndrome cell model.
Coronary Artery Disease
A Functional Relevance of the Anaphylatoxin Receptor C3aR for Platelet Function and Arterial Thrombus Formation Marks an Intersection Point Between Innate Immunity and Thrombosis.
Gene-smoking interactions in multiple Rho-GTPase pathway genes in an early-onset coronary artery disease cohort.
Potentially critical roles of TNPO1, RAP1B, ZDHHC17, and PPM1B in the progression of coronary atherosclerosis through microarray data analysis.
Costello Syndrome
A mouse model for Costello syndrome reveals an Ang II-mediated hypertensive condition.
Costello syndrome H-Ras alleles regulate cortical development.
Expression of H-RASV12 in a zebrafish model of Costello syndrome causes cellular senescence in adult proliferating cells.
Germline expression of H-Ras causes neurological deficits associated to Costello syndrome.
Molecules linked to Ras signaling as therapeutic targets in cardiac pathologies.
RasGRF1 regulates proliferation and metastatic behavior of human alveolar rhabdomyosarcomas.
Retinoblastoma protein modulates the inverse relationship between cellular proliferation and elastogenesis.
The role of p19 and p21 H-Ras proteins and mutants in miRNA expression in cancer and a Costello syndrome cell model.
[Mutations in H-Ras proto-oncogen in Costello syndrome]
COVID-19
Differential Expression of Rab5 and Rab7 Small GTPase Proteins in Placental Tissues From Pregnancies Affected by Maternal Coronavirus Disease 2019.
H-Ras gene takes part to the host immune response to COVID-19.
SARS-CoV-2 receptor ACE2 and TMPRSS2 are primarily expressed in bronchial transient secretory cells.
Craniosynostoses
Carpenter syndrome: extended RAB23 mutation spectrum and analysis of nonsense-mediated mRNA decay.
Clinical study and some molecular features of Mexican patients with syndromic craniosynostosis.
Genetic basis of potential therapeutic strategies for craniosynostosis.
Genetics of craniosynostosis: genes, syndromes, mutations and genotype-phenotype correlations.
Molecular Analysis of Gli3, Ihh, Rab23, and Jag1 in a Rabbit Model of Craniosynostosis: Likely Exclusion as the Loci of Origin.
Mutation Screening of Candidate Genes in Patients with Nonsyndromic Sagittal Craniosynostosis.
RAB23 mutations in Carpenter syndrome imply an unexpected role for hedgehog signaling in cranial-suture development and obesity.
Creutzfeldt-Jakob Syndrome
Prion protein deposition and abnormal synaptic protein expression in the cerebellum in Creutzfeldt-Jakob disease.
Sporadic Creutzfeldt-Jakob disease subtype-specific alterations of the brain proteome: impact on Rab3a recycling.
Crohn Disease
A genome-wide association study identifying RAP1A as a novel susceptibility gene for Crohn's disease in Japanese individuals.
Activating mutations in the k-ras gene in ulcerative-colitis and crohns-disease.
Dislocation of Rab13 and vasodilator-stimulated phosphoprotein in inactive colon epithelium in patients with Crohn's disease.
MicroRNA-15a - cell division cycle 42 signaling pathway in pathogenesis of pediatric inflammatory bowel disease.
New insights into the interplay between autophagy, gut microbiota and inflammatory responses in IBD.
Screening for p53 and K-ras mutations in whole-gut lavage in chronic inflammatory bowel disease.
TLR sorting by Rab11 endosomes maintains intestinal epithelial-microbial homeostasis.
Cryptococcosis
Two CDC42 paralogues modulate Cryptococcus neoformans thermotolerance and morphogenesis under host physiological conditions.
Cryptosporidiosis
Cdc42 and the actin-related protein/neural Wiskott-Aldrich syndrome protein network mediate cellular invasion by Cryptosporidium parvum.
Cushing Syndrome
Mutations of K-ras oncogene in human adrenal tumours in Taiwan.
Cystadenocarcinoma
K-ras mutations in stools and tissue samples from patients with malignant and nonmalignant pancreatic diseases.
K-ras mutations in tissue and stool samples from patients with pancreatic cancer and chronic pancreatitis.
K-ras oncogene mutations indicate malignancy in cystic tumors of the pancreas.
Cystadenocarcinoma, Mucinous
Appendiceal mucinous cystadenocarcinoma with mural nodules of anaplastic carcinoma and K-RAS mutation.
Cystadenocarcinoma, Serous
Stability of c-K-ras amplification during progression in a patient with adenocarcinoma of the ovary.
Cystadenoma
Detection of codon 12 mutation in the K-ras oncogene in pancreatic tumors.
Heterogeneous distribution of K-ras-mutated epithelia in mucinous ovarian tumors with special reference to histopathology.
Heterogeneous genetic alterations in ovarian mucinous tumors: application and usefulness of laser capture microdissection.
K-ras oncogene mutations indicate malignancy in cystic tumors of the pancreas.
[Serous genital carcinoma : Molecular pathogenesis and the role of tubal fimbria.]
Cystadenoma, Mucinous
Heterogeneous genetic alterations in ovarian mucinous tumors: application and usefulness of laser capture microdissection.
Cystadenoma, Serous
Molecular pathology of invasive carcinoma.
Cystic Adenomatoid Malformation of Lung, Congenital
Mucinous bronchioloalveolar carcinoma with K-ras mutation arising in type 1 congenital cystic adenomatoid malformation: a case report with review of the literature.
Cystic Fibrosis
A neutrophil intrinsic impairment affecting Rab27a and degranulation in cystic fibrosis is corrected by CFTR potentiator therapy.
ABCA1: regulation, trafficking and association with heteromeric proteins.
Burkholderia cenocepacia infection: Disruption of phagocyte immune functions through Rho GTPase inactivation.
CALEB/NGC interacts with the Golgi-associated protein PIST.
Cl- channels regulate lipid droplet formation via Rab8a expression during adipocyte differentiation.
Construction of in situ oligonucleotide arrays on plastic.
Elevated small GTPase activation influences the cell proliferation signaling control in Niemann-Pick type C fibroblasts.
Rab27a negatively regulates CFTR chloride channel function in colonic epithelia: involvement of the effector proteins in the regulatory mechanism.
Regulation of cystic fibrosis transmembrane regulator trafficking and protein expression by a Rho family small GTPase TC10.
Soluble normal and mutated DNA sequences from single-copy genes in human blood.
Cystinosis
Cystinosin, the small GTPase Rab11, and the Rab7 effector RILP regulate intracellular trafficking of the chaperone-mediated autophagy receptor LAMP2A.
Cystitis
H-ras immunohistochemical expression and molecular analysis of urinary bladder lesions in grazing adult cattle exposed to bracken fern.
Survey of ferns and clinico-pathological studies on the field cases of Enzootic bovine haematuria in Himachal Pradesh, a north-western Himalayan state of India.
Cysts
Actin, RhoA, and Rab11 participation during encystment in Entamoeba invadens.
Activated ras protein accelerates cell cycle progression to perturb madin-darby canine kidney cystogenesis.
Active K-RAS induces the coherent rotation of epithelial cells: A model for collective cell invasion in vitro.
Active Rab11 and functional recycling endosome are required for E-cadherin trafficking and lumen formation during epithelial morphogenesis.
Anisotropic expansion of hepatocyte lumina enforced by apical bulkheads.
Apical polarity proteins recruit the RhoGEF Cysts to promote junctional myosin assembly.
Cdc42 controls spindle orientation to position the apical surface during epithelial morphogenesis.
CDC42 is required for epicardial and pro-epicardial development by mediating FGF receptor trafficking to the plasma membrane.
CDC42-positive macrophages may prevent malignant transformation of ovarian endometriosis.
Comparison of carcinoembryonic antigen and molecular analysis in pancreatic cyst fluid.
Ectopic Thyroid Tissue in the Adrenal Gland: Report of a Case.
Expression of motility-related molecule Cdc42 in endometrial tissue in women with adenomyosis and ovarian endometriomata.
Formation of multicellular epithelial structures.
H-Ras mediates the inhibitory effect of epidermal growth factor on the epithelial Na+ channel.
Incidental Cystic Lesions in the Pancreas: Resect? EUS? Follow?
K-Ras and microsatellite marker analysis of fine-needle aspirates from intraductal papillary mucinous neoplasms of the pancreas.
K-ras Mutations Correlate with Atypical Cytology and Elevated CEA Levels in Pancreatic Cystic Neoplasms.
K-ras mutations in Müllerian inclusion cysts associated with serous borderline tumors of the ovary.
K-RAS mutations in ovarian and extraovarian lesions of serous tumors of borderline malignancy.
Molecular analysis of pancreatic cyst fluid: a comparative analysis with current practice of diagnosis.
Morphogenetic and Molecular Analyses of Cyst Wall Components in the Ciliated Protozoan Colpoda cucullus Nag-1.
Opening ahead: early steps in lumen formation revealed.
Pak1 regulates the orientation of apical polarization and lumen formation by distinct pathways.
Pancreatic carcinoma accompanied by pseudocyst: report of two cases.
Pancreatic cyst fluid analysis--a review.
Pancreatic cyst fluid DNA analysis in evaluating pancreatic cysts: a report of the PANDA study.
Par6B and Atypical PKC Regulate Mitotic Spindle Orientation during Epithelial Morphogenesis.
Proliferative signaling by ERBB proteins and RAF/MEK/ERK effectors in polycystic kidney disease.
Rab GTPase-Myo5B complexes control membrane recycling and epithelial polarization.
Rab11 and actin cytoskeleton participate in Giardia lamblia encystation, guiding the specific vesicles to the cyst wall.
Rab35 GTPase couples cell division with initiation of epithelial apico-basal polarity and lumen opening.
Rac1 orientates epithelial apical polarity through effects on basolateral laminin assembly.
Ras p21 in breast tissue: associations with pathology and cellular localisation.
RBD11, a bioengineered Rab11-binding module for visualizing and analyzing endogenous Rab11.
Regulation of podocalyxin trafficking by Rab small GTPases in 2D and 3D epithelial cell cultures.
Renal activation of extracellular signal-regulated kinase in rats with autosomal-dominant polycystic kidney disease.
Somatic support cells regulate germ cell survival through the Baz/aPKC/Par6 complex.
The effect of trehalose on autophagy-related proteins and cyst growth in a hypomorphic Pkd1 mouse model of autosomal dominant polycystic kidney disease.
The Rho family of small GTPases is involved in epithelial cystogenesis and tubulogenesis.
The role of pancreatic cyst fluid molecular analysis in predicting cyst pathology.
Tuba, a Cdc42 GEF, is required for polarized spindle orientation during epithelial cyst formation.
Zonula occludens-2 regulates Rho proteins activity and the development of epithelial cytoarchitecture and barrier function.
Cytomegalovirus Infections
Cdc42 and Rab8a are critical for intestinal stem cell division, survival, and differentiation in mice.
Drebrin E depletion in human intestinal epithelial cells mimics Rab8a loss of function.
Myosin Vb uncoupling from RAB8A and RAB11A elicits microvillus inclusion disease.
Rab11 Is a Useful Tool for the Diagnosis of Microvillous Inclusion Disease.
Deafness
DelGEF, a homologue of the Ran guanine nucleotide exchange factor RanGEF, binds to the exocyst component Sec5 and modulates secretion.
Pathogenetic basis of Takenouchi-Kosaki syndrome: Electron microscopy study using platelets in patients and functional studies in a Caenorhabditis elegans model.
Pleiotropic effects of coat colour-associated mutations in humans, mice and other mammals.
Dehydration
Cloning and characterization of a salt stress-inducible small GTPase gene from the model grass species Lolium temulentum.
Microbes in Cahoots with Plants: MIST to Hit the Jackpot of Agricultural Productivity during Drought.
Overexpression of a PLDalpha1 gene from Setaria italica enhances the sensitivity of Arabidopsis to abscisic acid and improves its drought tolerance.
Overexpression of a wheat phospholipase D gene, TaPLD?, enhances tolerance to drought and osmotic stress in Arabidopsis thaliana.
The expression of a rab-related gene, rab18, is induced by abscisic acid during the cold acclimation process of Arabidopsis thaliana (L.) Heynh.
The soybean U-box gene GmPUB6 regulates drought tolerance in Arabidopsis thaliana.
Dementia
Growth-associated protein GAP-43 in the frontal cortex and in the hippocampus in Alzheimer's disease: an immunohistochemical and quantitative study.
Protein farnesylation is upregulated in Alzheimer's human brains and neuron-specific suppression of farnesyltransferase mitigates pathogenic processes in Alzheimer's model mice.
Synaptic pathology in Alzheimer's disease: relation to severity of dementia, but not to senile plaques, neurofibrillary tangles, or the ApoE4 allele.
Synaptic proteins predict cognitive decline in Alzheimer's disease and Lewy body dementia.
Xanthoceras sorbifolia extracts ameliorate dendritic spine deficiency and cognitive decline via upregulation of BDNF expression in a rat model of Alzheimer's disease.
Demyelinating Diseases
Peripheral nerve demyelination caused by a mutant Rho GTPase guanine nucleotide exchange factor, frabin/FGD4.
Rac1 GTPase controls myelination and demyelination.
Dengue
Disentangling the role of PI3K/Akt, Rho GTPase and the actin cytoskeleton on dengue virus infection.
Effect of the Rho GTPase inhibitor-1 on the entry of dengue serotype 2 virus into EAhy926 cells.
Identification and characterization of a novel broad spectrum virus entry inhibitor.
Insight into structural organization and protein-protein interaction of non structural 3 (NS3) proteins from dengue serotypes.
Molecular dissection of dengue virus egress: involvement of the class II ARF small GTPase.
Rab18 Facilitates Dengue Virus Infection by Targeting Fatty Acid Synthase to Sites of Viral Replication.
Rab5 Enhances Classical Swine Fever Virus Proliferation and Interacts with Viral NS4B Protein to Facilitate Formation of NS4B Related Complex.
Rac1 and Cdc42 GTPases cross-talk regulates formation of filopodia required for Dengue virus type-2 entry into HMEC-1 cells.
Roles of small GTPase Rac1 in the regulation of actin cytoskeleton during dengue virus infection.
The non-structural 3 (NS3) protein of dengue virus type 2 interacts with human nuclear receptor binding protein and is associated with alterations in membrane structure.
Dental Pulp Calcification
Cell shape and epithelial patterning in the Drosophila embryonic epidermis.
Dermatitis, Phototoxic
Phototoxic effects of lysosome-associated genetically encoded photosensitizer KillerRed.
Diabetes Mellitus
IFN-?/mTORC1 decreased Rab11 in Schwann cells of diabetic peripheral neuropathy, inhibiting cell proliferation via GLUT1 downregulation.
Multicenter analysis of risk factors for anastomotic leakage after middle and low rectal cancer resection without diverting stoma: a retrospective study of 319 consecutive patients.
Past medical conditions and K-ras mutations in pancreatic ductal adenocarcinoma: a hypothesis-generating study.
Rab27a: a new face in beta cell metabolism-secretion coupling.
Renal gene expression in embryonic and newborn diabetic mice.
[Changes in functional state of the low-molecular G-proteins of platelets in type 1 diabetes mellitus]
Diabetes Mellitus, Type 1
Metformin Decreases Insulin Resistance in Type 1 Diabetes Through Regulating P53 and RAP2A in vitro and in vivo [Retraction].
Metformin Decreases Insulin Resistance in Type 1 Diabetes Through Regulating p53 and RAP2A in vitro and in vivo.
[Changes in functional state of the low-molecular G-proteins of platelets in type 1 diabetes mellitus]
Diabetes Mellitus, Type 2
Allosteric binding sites in Rab11 for potential drug candidates.
Cloning of Rab GTPases expressed in human skeletal muscle: studies in insulin-resistant subjects.
GGPPS-mediated Rab27A geranylgeranylation regulates ? cell dysfunction during type 2 diabetes development by affecting insulin granule docked pool formation.
Measuring gene-gene interaction using Kullback-Leibler divergence.
Multi-step pancreatic carcinogenesis and its clinical implications.
Rac1-NADPH oxidase signaling promotes CD36 activation under glucotoxic conditions in pancreatic beta cells.
Diabetes, Gestational
Down-regulation of microRNA-30d-5p is associated with gestational diabetes mellitus by targeting RAB8A.
Diabetic Cardiomyopathies
miR-30c Mediates Upregulation of Cdc42 and Pak1 in Diabetic Cardiomyopathy.
Diabetic Nephropathies
Gender Differences in Genetic Associations of RAB38 with Urinary Protein-to-Creatinine Ratio (UPCR) Levels in Diabetic Nephropathy Patients.
Genome-wide Association Studies Identify Genetic Loci Associated With Albuminuria in Diabetes.
Identification of up-regulated Ras-like GTPase, Rap1b, by suppression subtractive hybridization.
Inhibiting Rab27a in renal tubular epithelial cells attenuates the inflammation of diabetic kidney disease through the miR-26a-5p/CHAC1/NF-kB pathway.
Podocyte-specific Rac1 deficiency ameliorates podocyte damage and proteinuria in STZ-induced diabetic nephropathy in mice.
Protective effects of calcitriol on diabetic nephropathy are mediated by down regulation of TGF-?1 and CIP4 in diabetic nephropathy rat.
Ras-Related C3 Botulinum Toxin Substrate 1 Combining With the Mixed Lineage Kinase 3- Mitogen-Activated Protein Kinase 7- c-Jun N-Terminal Kinase Signaling Module Accelerates Diabetic Nephropathy.
Rho-kinase inhibition prevents the progression of diabetic nephropathy by downregulating hypoxia-inducible factor 1?.
ROCK2 regulates TGF-?-induced expression of CTGF and profibrotic genes via NF-?B and cytoskeleton dynamics in mesangial cells.
Diabetic Retinopathy
cGMP-dependent protein kinase phosphorylates p21-activated kinase (Pak) 1, inhibiting Pak/Nck binding and stimulating Pak/vasodilator-stimulated phosphoprotein association.
Diabetes regulates small molecular weight G-protein, H-Ras, in the microvasculature of the retina: Implication in the development of retinopathy.
Diabetic retinopathy and signaling mechanism for activation of matrix metalloproteinase-9.
Ras-related C3 botulinum toxin substrate 1 activation is involved in the pathogenesis of diabetic retinopathy.
Role of Matrix Metalloproteinase-9 in the Development of Diabetic Retinopathy and its Regulation by H-Ras.
Small GTPase ARF6 controls VEGFR2 trafficking and signaling in diabetic retinopathy.
Small molecular weight G-protein, H-Ras, and retinal endothelial cell apoptosis in diabetes.
Translocation of H-Ras and its implications in the development of diabetic retinopathy.
DiGeorge Syndrome
Palmitoylation of cdc42 Promotes Spine Stabilization and Rescues Spine Density Deficit in a Mouse Model of 22q11.2 Deletion Syndrome.
dihydropyrimidinase deficiency
Predictive and prognostic biomarkers with therapeutic targets in breast, colorectal, and non-small cell lung cancers: A systemic review of current development, evidence, and recommendation.
Dihydropyrimidine Dehydrogenase Deficiency
Predictive and prognostic biomarkers with therapeutic targets in breast, colorectal, and non-small cell lung cancers: A systemic review of current development, evidence, and recommendation.
Diphtheria
An Entamoeba histolytica ADP-ribosyl transferase from the diphtheria toxin family modifies the bacterial elongation factor Tu.
Escherichia coli cytotoxic necrotizing factor 1: evidence for induction of actin assembly by constitutive activation of the p21 Rho GTPase.
Disorders of Sex Development
Sex differences in autophagy-mediated diseases: toward precision medicine.
Diverticulitis
Expression of protooncogene-encoded mRNA by colonic epithelial cells in inflammatory bowel disease.
Down Syndrome
Detection of UV-induced K-ras codon 12 mutation by PCR and differential dot-blot hybridization in cells from Down syndrome and Cockayne syndrome.
Drug Resistant Epilepsy
[Overexpression of the Cdc42 in the brain tissue of human with intractable temporal epilepsy]
Dysgerminoma
K-ras gene point mutations and p21ras immunostaining in human ovarian tumors.
Dyskinesias
Rhes, a striatal-enriched small G protein, mediates mTOR signaling and L-DOPA-induced dyskinesia.
Dyslexia
Two Autism/Dyslexia Linked Variations of DOCK4 Disrupt the Gene Function on Rac1/Rap1 Activation, Neurite Outgrowth, and Synapse Development.
Ectodermal Dysplasia
Aplasia cutis congenita in a CDC42-related developmental phenotype.
Encephalitis
Pulmonary lymphomatoid granulomatosis in Griscelli syndrome type 2.
Encephalitis, Japanese
Rab5 and Rab11 Are Required for Clathrin-Dependent Endocytosis of Japanese Encephalitis Virus in BHK-21 Cells.
Encephalocele
Novel mouse model of encephalocele: post-neurulation origin and relationship to open neural tube defects.
Encephalomyelitis
miR-142a-3p promotes the proliferation of porcine hemagglutinating encephalomyelitis virus by targeting Rab3a.
You-Gui pills promote nerve regeneration by regulating netrin1, DCC and Rho family GTPases RhoA, Racl, Cdc42 in C57BL/6 mice with experimental autoimmune encephalomyelitis.
Encephalomyelitis, Autoimmune, Experimental
You-Gui pills promote nerve regeneration by regulating netrin1, DCC and Rho family GTPases RhoA, Racl, Cdc42 in C57BL/6 mice with experimental autoimmune encephalomyelitis.
Endometrial Hyperplasia
Alteration of the k-ras gene expression in atypical and nonatypical hyperplastic endometrium.
Biomarkers in the endometrium.
Clonal analysis and mutations in the PTEN and the K-ras genes in endometrial hyperplasia.
Genetics of endometrial cancers.
K-ras activation in premalignant and malignant epithelial lesions of the human uterus.
K-ras mutation in tamoxifen-related endometrial polyps.
K-ras mutations appear in the premalignant phase of both microsatellite stable and unstable endometrial carcinogenesis.
K-ras mutations in endometrial carcinomas with microsatellite instability.
Molecular basis of endometrial cancer.
Molecular genetic pathways in various types of endometrial carcinoma: from a phenotypical to a molecular-based classification.
New concepts in the diagnosis and prognosis of endometrial carcinoma.
Surgical treatment of high stage endometrial cancer: current perspectives.
Endometrial Neoplasms
Abnormalities in the NF-kappaB family and related proteins in endometrial carcinoma.
Alteration of the k-ras gene expression in atypical and nonatypical hyperplastic endometrium.
Alteration of the p53 tumor suppressor gene and activation of c-K-ras-2 protooncogene in endometrial adenocarcinoma from Colorado.
Alterations of the K-ras and p53 genes in Tamoxifen-associated endometrial carcinoma.
Analysis of point mutations at codon 12 of K-ras in human endometrial carcinoma and cervical adenocarcinoma by dot blot hybridization and polymerase chain reaction.
Another Surprise from Metformin: Novel Mechanism of Action via K-Ras Influences Endometrial Cancer Response to Therapy.
Biomarkers in the endometrium.
Carcinogenic mechanisms of endometrial cancer: involvement of genetics and epigenetics.
Chromosomal deletions and K-ras gene mutations in human endometrial carcinomas.
Chromosome aberrations [dup(1q)] in endometrial cancer: Gene analysis of 54 surgical specimens in Turkey.
Clinical implications of K-ras mutations in malignant epithelial tumors of the endometrium.
Clinicopathological and molecular analysis of endometrial carcinoma associated with tamoxifen.
Detection of clonality and genetic alterations in endometrial pipelle biopsy and its surgical specimen counterpart.
Detection of human papillomavirus types 16 and 18 in human neoplastic endometrium: lack of correlation with established prognostic factors.
Detection of K-ras mutations in cancerous lesions of human endometrium.
Distinct molecular alterations in complex endometrial hyperplasia (CEH) with and without immature squamous metaplasia (squamous morules).
Endometrial cancer side-population cells show prominent migration and have a potential to differentiate into the mesenchymal cell lineage.
Endometrial carcinomas with significant mucinous differentiation associated with higher frequency of k-ras mutations: a morphologic and molecular correlation study.
Evidence for different expression profiles for c-Met, EGFR, PTEN and the mTOR pathway in low and high grade endometrial carcinomas in a cohort of consecutive women. Occurrence of PIK3CA and K-Ras mutations and microsatellite instability.
Fendiline inhibits K-Ras plasma membrane localization and blocks K-Ras signal transmission.
Genetic Alterations in SMAD4 and K-ras in Serbian Patients With Endometrial Carcinoma.
Genotype-dependent efficacy of a dual PI3K/mTOR inhibitor, NVP-BEZ235, and an mTOR inhibitor, RAD001, in endometrial carcinomas.
Geraniol Inhibits Endometrial Carcinoma via Downregulating Oncogenes and Upregulating Tumour Suppressor Genes.
Immunohistochemical analysis of MIB-1 proliferative activity in human endometrial cancer. Correlation with clinicopathological parameters, patient outcome, retinoblastoma immunoreactivity and K-ras codon 12 point mutations.
K-ras activation in neoplasms of the human female reproductive tract.
K-ras exon 2 point mutations in human endometrial cancer.
K-ras gene point mutations in human endometrial carcinomas: correlation with clinicopathological features and patients' outcome.
K-ras mutations in endometrial carcinomas with microsatellite instability.
K-ras point mutations in endometrial carcinoma: effect on outcome is dependent on age of patient.
K-ras point mutations in spontaneously occurring endometrial adenocarcinomas in the Donryu rat.
K-Ras stabilization by estrogen via PKC? is involved in endometrial tumorigenesis.
LncRNA LOXL1-AS1 promotes endometrial cancer progression by sponging miR-28-5p to upregulate RAP1B expression.
MGMT promoter hypermethylation and K-RAS, PTEN and TP53 mutations in tamoxifen-exposed and non-exposed endometrial cancer cases.
Microsatellite instability and somatic mutations in endometrial carcinomas.
Model for the molecular genetic diagnosis of endometrial cancer using K-ras mutation analysis.
Molecular assessment of depth of myometrial invasion in stage I endometrial cancer: a model based on K-ras mutation analysis.
Molecular basis of endometrial cancer.
Molecular differences between RER+ and RER- sporadic endometrial carcinomas in a large population-based series.
Molecular genetic characterization of tamoxifen-associated endometrial cancer.
Molecular genetics of gynecologic cancer.
Molecular pathology of endometrial carcinoma: transcriptional signature in endometrioid tumors.
Monitoring of endometrial K-ras mutation in tamoxifen-treated patients with breast cancer.
Mutations and amplification of oncogenes in endometrial cancer.
New concepts in the diagnosis and prognosis of endometrial carcinoma.
Novel molecular profiles of endometrial cancer-new light through old windows.
Oncogenic Ras modulates epidermal growth factor responsiveness in endometrial carcinomas.
Phase I, Open-Label, Dose-Escalation/Dose-Expansion Study of Lifirafenib (BGB-283), an RAF Family Kinase Inhibitor, in Patients With Solid Tumors.
PIK3CA gene mutations in endometrial carcinoma: correlation with PTEN and K-RAS alterations.
Predicting everolimus treatment efficacy in patients with advanced endometrial carcinoma: a GINECO group study.
Promoter hypermethylation and expression of sprouty 2 in endometrial carcinoma.
Promoter hypermethylation and reduced expression of RASSF1A are frequent molecular alterations of endometrial carcinoma.
ras gene mutations in human endometrial carcinoma.
RASSF1A methylation and K-ras and B-raf mutations and recurrent endometrial cancer.
RB protein expression in human endometrial carcinomas--an immunohistochemical study.
Studies on ras oncogene activation in endometrial carcinoma.
Surgical treatment of high stage endometrial cancer: current perspectives.
The clinicopathological significance of K-RAS point mutation and gene amplification in endometrial cancer.
The inhibitory effect of salinomycin on the proliferation, migration and invasion of human endometrial cancer stem-like cells.
The Synergistic Effect of Conditional Pten Loss and Oncogenic K-ras Mutation on Endometrial Cancer Development Occurs via Decreased Progesterone Receptor Action.
Tumorigenesis of K-ras mutation in human endometrial carcinoma via upregulation of estrogen receptor.
[Carcinogenesis and its mechanism of mutant-type[12Asp]K-ras4B gene]
[Endometrial carcinoma and precursor lesions]
[Gene K-ras mutation in cells of endometrial adenocarcinoma in women]
[Targeting Ras-PI3K/mTOR pathway and the predictive biomarkers in endometrial cancer].
[The factors involved in invasive ability of endometrial carcinoma cells]
Endometriosis
Activation of mutated K-ras in donor endometrial epithelium and stroma promotes lesion growth in an intact immunocompetent murine model of endometriosis.
CDC42-positive macrophages may prevent malignant transformation of ovarian endometriosis.
Endometriosis risk alleles at 1p36.12 act through inverse regulation of CDC42 and LINC00339.
Expression of motility-related molecule Cdc42 in endometrial tissue in women with adenomyosis and ovarian endometriomata.
Fine mapping of variants associated with endometriosis in the WNT4 region on chromosome 1p36.
K-Ras 4A Transcript variant is up-regulated in eutopic endometrium of endometriosis patients during proliferative phase of menstrual cycle.
K-ras mutation may promote carcinogenesis of endometriosis leading to ovarian clear cell carcinoma.
Malignant transformation of endometriosis and genetic alterations of K-ras and microsatellite instability.
Molecular mechanisms and biological plausibility underlying the malignant transformation of endometriosis: a critical analysis.
Novel ovarian endometriosis model causes infertility via iron-mediated oxidative stress in mice.
Role of K-ras and Pten in the development of mouse models of endometriosis and endometrioid ovarian cancer.
Endotoxemia
Hepatic Rac1 GTPase contributes to liver-mediated basal immune homeostasis and LPS-induced endotoxemia.
Increased survival and reduced neutrophil infiltration of the liver in rab27a- but not munc13-4-deficient mice in lipopolysaccharide-induced systemic inflammation.
Enteritis
1,25-Dihydroxyvitamin D3 and dietary vitamin D reduce inflammation in mice lacking intestinal epithelial cell Rab11a.
Identification and cloning of two immunogenic Clostridium perfringens proteins, elongation factor Tu (EF-Tu) and pyruvate:ferredoxin oxidoreductase (PFO) of C. perfringens.
Rab11 Is a Useful Tool for the Diagnosis of Microvillous Inclusion Disease.
Eosinophilia
A case of therapy-related acute myeloid leukemia with inv(16)(p13.1q22) after single low-dose iodine-131 treatment for thyroid cancer.
Differential expression and activation of Rab27A in human eosinophils: relationship to blood eosinophilia.
Epidermal Cyst
The radiosensitivity of human keratinocytes: influence of activated c-H-ras oncogene expression and tumorigenicity.
Epilepsy
Aurora A plays a dual role in migration and survival of human glioblastoma cells according to the CXCL12 concentration.
Inhibition of the small GTPase Cdc42 in regulation of epileptic-seizure in rats.
Mutations in the small GTPase gene RAB39B are responsible for X-linked mental retardation associated with autism, epilepsy, and macrocephaly.
[Overexpression of the Cdc42 in the brain tissue of human with intractable temporal epilepsy]
Epilepsy, Temporal Lobe
Inhibition of the small GTPase Cdc42 in regulation of epileptic-seizure in rats.
Epstein-Barr Virus Infections
Molecular characterization of primary mediastinal B cell lymphoma.
Possible association of active gastritis, featuring accelerated cell turnover and p53 overexpression, with cancer development at anastomoses after gastrojejunostomy. Comparison with gastroduodenostomy.
Esophageal Neoplasms
Assessment of epidermal growth factor receptor mutation/copy number and K-ras mutation in esophageal cancer.
Characterization and effects of miR-21 expression in esophageal cancer.
Deregulation of SLIT2-Mediated Cdc42 Activity Is Associated with Esophageal Cancer Metastasis and Poor Prognosis.
Effect of blocking Ras signaling pathway with K-Ras siRNA on apoptosis in esophageal squamous carcinoma cells.
K-ras Mutation, HPV Infection and Smoking or Alcohol Abuse Positively Correlate with Esophageal Squamous Carcinoma.
MiR-196a binding-site SNP regulates RAP1A expression contributing to esophageal squamous cell carcinoma risk and metastasis.
Regulation of CXCR4/AKT-signaling-induced cell invasion and tumor metastasis by RhoA, Rac-1, and Cdc42 in human esophageal cancer.
Relationship between H-ras p21 product and p53 protein or high-risk human papillomaviruses in esophageal cancer from Kochi, Japan.
RNAi-induced K-Ras Gene Silencing Suppresses Growth of EC9706 Cells and Enhances Chemotherapy Sensitivity of Esophageal Cancer.
Suppression of Erk activation and in vivo growth in esophageal cancer cells by the dominant negative Ras mutant, N116Y.
The expression of H-ras p21 product in esophageal cancer from Hong Kong Chinese.
TNK2 promoted esophageal cancer progression via activating egfr-akt signaling.
Esophageal Squamous Cell Carcinoma
An association study on genetic polymorphisms of Rab37 gene with the risk of esophageal squamous cell carcinoma in a Chinese Han population.
Deregulation of SLIT2-Mediated Cdc42 Activity Is Associated with Esophageal Cancer Metastasis and Poor Prognosis.
Differential expression of miR-195 in esophageal squamous cell carcinoma and miR-195 expression inhibits tumor cell proliferation and invasion by targeting of Cdc42.
Dysregulation of Rab37-Mediated Cross-talk between Cancer Cells and Endothelial Cells via Thrombospondin-1 Promotes Tumor Neovasculature and Metastasis.
Filamin C promotes lymphatic invasion and lymphatic metastasis and increases cell motility by regulating Rho GTPase in esophageal squamous cell carcinoma.
Interrelationship between the expression of h-ras p21, C-myc and p53 proteins, and the infection of high-risk human papillomaviruses in Japanese patients with esophageal squamous-cell carcinoma.
microRNA-195-Cdc42 axis acts as a prognostic factor of esophageal squamous cell carcinoma.
MicroRNA-429 inhibits the proliferation and migration of esophageal squamous cell carcinoma cells by targeting RAB23 through the NF-?B pathway.
miR-107 functions as a tumor suppressor in human esophageal squamous cell carcinoma and targets Cdc42.
MiR-196a binding-site SNP regulates RAP1A expression contributing to esophageal squamous cell carcinoma risk and metastasis.
miR-518b is down-regulated, and involved in cell proliferation and invasion by targeting Rap1b in esophageal squamous cell carcinoma.
RAB23, regulated by miR-92b, promotes the progression of esophageal squamous cell carcinoma.
Rap1A promotes esophageal squamous cell carcinoma metastasis through the AKT signaling pathway.
RAP1B, a DVL2 binding protein, activates Wnt/beta-catenin signaling in esophageal squamous cell carcinoma.
The Rho GTPase RhoE exerts tumor-suppressing effects in human esophageal squamous cell carcinoma via negatively regulating epidermal growth factor receptor.
Exanthema
Clinical use of anti-epidermal growth factor receptor monoclonal antibodies in metastatic colorectal cancer.
Molecular cloning of cDNAs encoding a guanine-nucleotide-releasing factor for Ras p21.
Polymorphisms in cyclooxygenase-2 and epidermal growth factor receptor are associated with progression-free survival independent of K-ras in metastatic colorectal cancer patients treated with single-agent cetuximab.
Ral-GTPases mediate a distinct downstream signaling pathway from Ras that facilitates cellular transformation.
[Cetuximab (Erbitux)]
Exocrine Pancreatic Insufficiency
Mutant-enriched PCR and allele-specific hybridization reaction to detect K-ras mutations in stool DNA: high prevalence in a large sample of older adults.
Fanconi Anemia
Defective homing is associated with altered Cdc42 activity in cells from patients with Fanconi anemia group A.
Rho GTPases in hematopoiesis and hemopathies.
Fasciculation
p190 RhoGAP is the principal Src substrate in brain and regulates axon outgrowth, guidance and fasciculation.
The small GTPase Rac is involved in clustering of hippocampal neurons and fasciculation of their neurites.
Fatty Liver
Integrated Analysis and Identification of Novel Biomarkers in Parkinson's Disease.
Fetal Alcohol Spectrum Disorders
Ethanol impairs Rho GTPase signaling and differentiation of cerebellar granule neurons in a rodent model of fetal alcohol syndrome.
Fetal Growth Retardation
Down-regulation of placental Cdc42 and Rac1 links mTORC2 inhibition to decreased trophoblast amino acid transport in human intrauterine growth restriction.
Fibrosarcoma
70 kDa heat shock cognate protein is a transformation-associated antigen and a possible target for the host's anti-tumor immunity.
A calcium binding protein, S100A4, mediates T cell dependent cytotoxicity as a transformation-associated antigen.
A disconnect between antitumor and antiangiogenic effects of fluvastatin in vitro and in vivo.
A PSP94-derived peptide PCK3145 inhibits MMP-9 secretion and triggers CD44 cell surface shedding: implication in tumor metastasis.
Absence of ras-gene hot-spot mutations in canine fibrosarcomas and melanomas.
Activation of K-ras and oncogenes other than ras family in rat fibrosarcomas induced by 1,8-dinitropyrene.
Active H-ras and N-ras in rat fibrosarcomas induced by 1,6-dinitropyrene.
Differential contribution of the ERK and JNK mitogen-activated protein kinase cascades to Ras transformation of HT1080 fibrosarcoma and DLD-1 colon carcinoma cells.
Exosome secretion promotes chemotaxis of cancer cells.
Expression of the ras-related rap genes in human tumors.
Genetic analysis of the Kirsten-ras-revertant 1 gene: potentiation of its tumor suppressor activity by specific point mutations.
Insulin like growth factor-1 selectively regulates the expression of matrix metalloproteinase-2 in malignant H-ras transformed cells.
Involvement of peptide antigens in the cytotoxicity between 70-kDa heat shock cognate protein-like molecule and CD3+, CD4-, CD8-, TCR-alpha beta- killer T cells.
Molecular cloning of rat NK target structure--the possibility of CD44 involvement in NK cell-mediated lysis.
Rab11-mediated focal adhesion turnover in sarcoma cell migration.
S-Adenosylmethionine decarboxylase gene expression is regulated by the cAMP signal transduction pathway in H-ras transformed fibrosarcoma cells capable of malignant progression.
S-adenosylmethionine decarboxylase gene expression is regulated by the cAMP signal transduction pathway in H-ras transformed fibrosarcoma cells capable of malignant progression.
The Arp2/3 complex mediates multigeneration dendritic protrusions for efficient 3-dimensional cancer cell migration.
Tissue factor pathway inhibitor-2 suppresses the production of active matrix metalloproteinase-2 and is down-regulated in cells harboring activated ras oncogenes.
Transforming growth factor beta 1 selectively regulates ornithine decarboxylase gene expression in malignant H-ras transformed fibrosarcoma cell lines.
Tumor-derived expression of vascular endothelial growth factor is a critical factor in tumor expansion and vascular function.
Foot-and-Mouth Disease
Foot-and-mouth disease virus degrades Rab27a to suppress the exosome-mediated antiviral immune response.
G3BP1 interacts directly with the FMDV IRES and negatively regulates translation.
Fragile X Syndrome
The small GTPase Arf6 is dysregulated in a mouse model for fragile X syndrome.
Frontotemporal Lobar Degeneration
Altered Expression of Circulating Cdc42 in Frontotemporal Lobar Degeneration.
Galactosemias
Diabetes regulates small molecular weight G-protein, H-Ras, in the microvasculature of the retina: Implication in the development of retinopathy.
Gallbladder Neoplasms
A MEK inhibitor (U0126) prolongs survival in nude mice bearing human gallbladder cancer cells with K-ras mutation: analysis in a novel orthotopic inoculation model.
Analysis of K-ras gene mutations in periampullary cancers, gallbladder cancers and cholangiocarcinomas from paraffin-embedded tissue sections.
Detection of ras oncogene point mutations and simultaneous proliferative fraction estimation in gallbladder cancer.
Epithelial cell proliferation and gene mutation in the mucosa of gallbladder with pancreaticobiliary malunion and cancer.
High frequency of TP53 but not K-ras gene mutations in Bolivian patients with gallbladder cancer.
K-ras mutation, p53 overexpression, and microsatellite instability in biliary tract cancers: a population-based study in China.
K-ras oncogene mutation in cancer and precancerous lesions of the gallbladder.
K-ras, p53 mutations, and microsatellite instability (MSI) in gallbladder cancer.
Mutational spectrum of K-ras oncogene among Indian patients with gallbladder cancer.
p53 gene mutation and p53 protein overexpression in a patient with simultaneous double cancer of the gallbladder and bile duct associated with pancreaticobiliary maljunction.
Prognostic Significance of K- ras Codon 12 Mutation in Patients with Resected Gallbladder Cancer.
Rac GTPase activating protein 1 promotes gallbladder cancer via binding DNA ligase 3 to reduce apoptosis.
Relation between K-ras codon 12 mutation and p53 protein overexpression in gallbladder cancer and biliary ductal epithelia in patients with pancreaticobiliary maljunction.
Sporadic TP53 transition mutations in chronic cholecystitis are possibly linked to gallbladder carcinogenesis.
Tumor Protein p53 and K-ras Gene Mutations in Peruvian Patients with Gallbladder Cancer
Usefulness of K-ras gene mutation at codon 12 in bile for diagnosing biliary strictures.
[K-ras gene mutation in gallbladder carcinoma]
Ganglioneuroblastoma
Specific expression of the ras-related rab3A gene in human normal and malignant neuroendocrine cells.
Gastrinoma
[Alteration of the K-ras and p16/CDKN2 gene in endocrine pancreatic carcinomas]
[Detection of H-ras and K-ras in tumors of gastrointestinal-pancreatic system]
Gastritis
Braf, Kras and Helicobacter pylori epigenetic changes-associated chronic gastritis in Egyptian patients with and without gastric cancer.
K-ras mutation in helicobacter pylori-associated chronic gastritis in patients with and without gastric cancer.
K-ras mutations and cell kinetics in Helicobacter pylori associated gastric intestinal metaplasia: a comparison before and after eradication in patients with chronic gastritis and gastric cancer.
[Study on association between an H-RAS gene polymorphism and gastric cancer development]
Gastritis, Atrophic
[Gene expression profiling using oligonucleotide microarray in atrophic gastritis and intestinal metaplasia]
[Genome analyses for precancerous lesions in the gastrointestinal tract]
Gastroenteritis
A Novel Mouse Model of Enteric Vibrio parahaemolyticus Infection Reveals that the Type III Secretion System 2 Effector VopC Plays a Key Role in Tissue Invasion and Gastroenteritis.
Gastrointestinal Diseases
Molecular detection of codon 12 K-RAS mutations in circulating DNA from serum of colorectal cancer patients.
Gastrointestinal Neoplasms
A highly sensitive method for K-ras mutation detection is useful in diagnosis of gastrointestinal cancer.
Association between H-RAS T81C genetic polymorphism and gastrointestinal cancer risk: a population based case-control study in China.
Clinical update on K-Ras targeted therapy in gastrointestinal cancers.
Frameshift mutations at mononucleotide repeats in caspase-5 and other target genes in endometrial and gastrointestinal cancer of the microsatellite mutator phenotype.
Molecular markers predictive of response to chemotherapy in gastrointestinal tumors.
Mutant-enriched PCR and allele-specific hybridization reaction to detect K-ras mutations in stool DNA: high prevalence in a large sample of older adults.
The effect of forced expression of mutated K-RAS gene on gastrointestinal cancer cell lines and the IGF-1R targeting therapy.
The Efficacy of IGF-I Receptor Monoclonal Antibody against Human Gastrointestinal Carcinomas is Independent of k-ras Mutation Status.
Gastrointestinal Stromal Tumors
Prognostic value of Rab27B nuclear expression in gastrointestinal stromal tumors.
Genetic Diseases, Inborn
A role for the vesicle-associated tubulin binding protein ARL6 (BBS3) in flagellum extension in Trypanosoma brucei.
Expression of H-RASV12 in a zebrafish model of Costello syndrome causes cellular senescence in adult proliferating cells.
Molecular inversion probes equipped with discontinuous rolling cycle amplification for targeting nucleotide variants: Determining SMN1 and SMN2 genes in diagnosis of spinal muscular atrophy.
Pediatric Hemophagocytic Lymphohistiocytosis (HLH).
Rab GTPases implicated in inherited and acquired disorders.
Rab27 effectors, pleiotropic regulators in secretory pathways.
Suppression of oncogenic Ras by mutant neurofibromatosis type 1 genes with single amino acid substitutions.
Giant Cell Tumor of Bone
Dosage and allelic restriction fragment studies and PCR analysis of the H-ras locus in giant cell tumor of bone.
STAT1, IGF1, RAC1, and MDM2 Are Associated with Recurrence of Giant Cell Tumor of Bone.
Giant Cell Tumors
Dosage and allelic restriction fragment studies and PCR analysis of the H-ras locus in giant cell tumor of bone.
K-ras oncogene mutations in osteoclast-like giant cell tumors of the pancreas and liver: genetic evidence to support origin from the duct epithelium.
Origin of giant cells in osteoclast-like giant cell tumors of the pancreas.
STAT1, IGF1, RAC1, and MDM2 Are Associated with Recurrence of Giant Cell Tumor of Bone.
Gingival Overgrowth
Lack of mutation in p53 and H-ras genes in phenytoin induced gingival overgrowth suggests its non cancerous nature.
Glaucoma
Chemo-informatics guided study of natural inhibitors targeting rho GTPase: a lead for treatment of glaucoma.
Elevated intraocular pressure induces Rho GTPase mediated contractile signaling in the trabecular meshwork.
Rho GTPase/Rho kinase inhibition as a novel target for the treatment of glaucoma.
Glaucoma, Open-Angle
Elevated intraocular pressure induces Rho GTPase mediated contractile signaling in the trabecular meshwork.
Glioblastoma
?v?8 integrin interacts with RhoGDI1 to regulate Rac1 and Cdc42 activation and drive glioblastoma cell invasion.
A role for activated Cdc42 in glioblastoma multiforme invasion.
Activated Ras induces cytoplasmic vacuolation and non-apoptotic death in glioblastoma cells via novel effector pathways.
Activation of RhoB by hypoxia controls hypoxia-inducible factor-1alpha stabilization through glycogen synthase kinase-3 in U87 glioblastoma cells.
Active ras triggers death in glioblastoma cells through hyperstimulation of macropinocytosis.
AEG-1 promotes mesenchymal transition through the activation of Rho GTPases in human glioblastoma cells.
An Arf/Rab cascade controls the growth and invasiveness of glioblastoma.
Cdc42 and the guanine nucleotide exchange factors Ect2 and trio mediate Fn14-induced migration and invasion of glioblastoma cells.
Chromosomal changes and correspondingly altered proto-oncogene expression in human gliomas. Value of combined cytogenetic and molecular genetic analysis.
Combined erbB gene overexpression and decreased H-ras gene expression in human gliomas.
Daam1 activates RhoA to regulate Wnt5a?induced glioblastoma cell invasion.
Down-regulation of K-ras and H-ras in human brain gliomas.
Epigenetic suppression of EGFR signaling in G-CIMP+ glioblastomas.
Functional Blockade of Small GTPase RAN Inhibits Glioblastoma Cell Viability.
Human Mena associates with Rac1 small GTPase in glioblastoma cell lines.
Hypoxia-induced acetylation of PAK1 enhances autophagy and promotes brain tumorigenesis via phosphorylating ATG5.
In vivo fluorescence resonance energy transfer imaging reveals differential activation of Rho-family GTPases in glioblastoma cell invasion.
Let-7 microRNA inhibits the proliferation of human glioblastoma cells.
Lovastatin and perillyl alcohol inhibit glioma cell invasion, migration, and proliferation--impact of Ras-/Rho-prenylation.
Luteolin inhibits migration of human glioblastoma U-87 MG and T98G cells through downregulation of Cdc42 expression and PI3K/AKT activity.
miR-181 subunits enhance the chemosensitivity of temozolomide by Rap1B-mediated cytoskeleton remodeling in glioblastoma cells.
miR-29a/b/c function as invasion suppressors for gliomas by targeting CDC42 and predict the prognosis of patients.
Rab27b contributes to radioresistance and exerts a paracrine effect via epiregulin in glioblastoma.
RAB38 confers a poor prognosis, associated with malignant progression and subtype preference in glioma.
RAB38 Facilitates Energy Metabolism and Counteracts Cell Death in Glioblastoma Cells.
Rab3a promotes brain tumor initiation and progression.
Redox biology in normal cells and cancer: Restoring function of the redox/Fyn/c-Cbl pathway in cancer cells offers new approaches to cancer treatment.
RND2 attenuates apoptosis and autophagy in glioblastoma cells by targeting the p38 MAPK signalling pathway.
RND3 promotes Snail 1 protein degradation and inhibits glioblastoma cell migration and invasion.
Signaling determinants of glioma cell invasion.
Signaling Determinants of Glioma Cell Invasion.
Small G protein Rac GTPases regulate the maintenance of glioblastoma stem-like cells in vitro and in vivo.
Small GTPase RHOE/RND3, a new critical regulator of NF-?B signalling in glioblastoma multiforme?
SPARC-induced migration of glioblastoma cell lines via uPA-uPAR signaling and activation of small GTPase RhoA.
Tax-interacting protein 1 coordinates the spatiotemporal activation of Rho GTPases and regulates the infiltrative growth of human glioblastoma.
The Ras-related protein, Rap1A, mediates thrombin-stimulated, integrin-dependent glioblastoma cell proliferation and tumor growth.
The Role of Rho GTPases in Motility and Invasion of Glioblastoma Cells.
The small GTPase RhoG mediates glioblastoma cell invasion.
Upregulated miRNA-622 inhibited cell proliferation, motility, and invasion via repressing Kirsten rat sarcoma in glioblastoma.
Glioma
4-Hydroxytamoxifen induces autophagic death through K-Ras degradation.
A genetically tractable model of human glioma formation.
A role for activated Cdc42 in glioblastoma multiforme invasion.
A software application for comparing large numbers of high resolution MALDI-FTICR MS spectra demonstrated by searching candidate biomarkers for glioma blood vessel formation.
A tree shrew glioblastoma model recapitulates features of human glioblastoma.
ADP-ribosylation factor 6 regulates glioma cell invasion through the IQ-domain GTPase-activating protein 1-Rac1-mediated pathway.
Alphavbeta3 and alphavbeta5 integrins control glioma cell response to ionising radiation through ILK and RhoB.
An imbalance between Smad and MAPK pathways is responsible for TGF-beta tumor promoting effects in high-grade gliomas.
Cathepsin L is involved in X-ray-induced invasion and migration of human glioma U251 cells.
Cdc42 and the guanine nucleotide exchange factors Ect2 and trio mediate Fn14-induced migration and invasion of glioblastoma cells.
CircRNA hsa_circ_0030018 regulates the development of glioma via regulating the miR-1297/RAB21 axis.
Combined erbB gene overexpression and decreased H-ras gene expression in human gliomas.
Decreased expression of miR-410-3p correlates with poor prognosis and tumorigenesis in human glioma.
Down-regulation of K-ras and H-ras in human brain gliomas.
Downregulation of ARHGDIA contributes to human glioma progression through activation of Rho GTPase signaling pathway.
Dynamin 2 mediates PDGFR?-SHP-2-promoted glioblastoma growth and invasion.
Effect of Ras-guanine nucleotide release factor 1-mediated H-Ras/ERK signaling pathway on glioma.
Effects of Rab27a on proliferation, invasion, and anti-apoptosis in human glioma cell.
EGFR inhibition in glioma cells modulates Rho signaling to inhibit cell motility and invasion and cooperates with temozolomide to reduce cell growth.
Elevated IQGAP1 and CDC42 levels correlate with tumor malignancy of human glioma.
Enhanced glioma-targeting and stability of LGICP peptide coupled with stabilized peptide DA7R.
Enriched environment reduces glioma growth through immune and non-immune mechanisms in mice.
Exosomal miR-2276-5p in Plasma Is a Potential Diagnostic and Prognostic Biomarker in Glioma.
Expression and correlation of Rab23 with pathological grades in human glioma cells.
Genetic alterations in brain tumors following 1,3-butadiene exposure in B6C3F1 mice.
GFAP-Cre-Mediated Activation of Oncogenic K-ras Results in Expansion of the Subventricular Zone and Infiltrating Glioma.
Glioma formation in neurofibromatosis 1 reflects preferential activation of K-RAS in astrocytes.
Glioma-Targeted Drug Delivery Enabled by a Multifunctional Peptide.
GOLPH3 regulates the migration and invasion of glioma cells though RhoA.
Hypomethylated Rab27b is a progression-associated prognostic biomarker of glioma regulating MMP-9 to promote invasion.
Hypoxia-induced acetylation of PAK1 enhances autophagy and promotes brain tumorigenesis via phosphorylating ATG5.
Illuminating Radiogenomic Characteristics of Glioblastoma Multiforme through Integration of MR Imaging, Messenger RNA Expression, and DNA Copy Number Variation.
Implications of Rho GTPase Signaling in Glioma Cell Invasion and Tumor Progression.
In contrast to EGFr gene overexpression, H-ras gene expression decreases in human gliomas.
Inhibition of glioma cell lysosome exocytosis inhibits glioma invasion.
Inhibition of H-ras as a treatment for experimental brain C6 glioma.
Inhibition of Rho pathways induces radiosensitization and oxygenation in human glioblastoma xenografts.
Insulin-like growth factor binding protein 2 promotes glioma development and progression.
Knockdown of Rab21 inhibits proliferation and induces apoptosis in human glioma cells.
Long non-coding RNA MALAT1 promotes proliferation and suppresses apoptosis of glioma cells through derepressing Rap1B by sponging miR-101.
Loss of p53 cooperates with K-ras activation to induce glioma formation in a region-independent manner.
LRRC4 inhibits glioblastoma cell proliferation, migration, and angiogenesis by downregulating pleiotropic cytokine expression and responses.
LRRC4 inhibits glioma cell growth and invasion through a miR-185-dependent pathway.
Micro-editing mistake translates into a devastating brain tumor.
MicroRNA-384 inhibits proliferation migration and invasion of glioma by targeting at CDC42.
MicroRNA-599 suppresses glioma progression by targeting RAB27B.
MiR-181d acts as a tumor suppressor in glioma by targeting K-ras and Bcl-2.
MiR-199a Inhibits Tumor Growth and Attenuates Chemoresistance by Targeting K-RAS via AKT and ERK Signalings.
miR-200b as a prognostic factor targets multiple members of RAB family in glioma.
miR-29a/b/c function as invasion suppressors for gliomas by targeting CDC42 and predict the prognosis of patients.
NEDD9 regulates 3D migratory activity independent of the Rac1 morphology switch in glioma and neuroblastoma.
Oligodendrocyte-type-2 astrocyte (O-2A) progenitor cells transformed with c-myc and H-ras form high-grade glioma after stereotactic injection into the rat brain.
Oncogenic signaling is dominant to cell of origin and dictates astrocytic or oligodendroglial tumor development from oligodendrocyte precursor cells.
Organotypic brain explant culture as a drug evaluation system for malignant brain tumors.
Over-expression of Rap2a inhibits glioma migration and invasion by down-regulating p-AKT.
Overexpressed let-7a inhibits glioma cell malignancy by directly targeting K-ras, independently of PTEN.
PTEN gene transfer suppresses the invasive potential of human malignant gliomas by regulating cell invasion-related molecules.
Rab18 interacted with V-set and immunoglobulin domain-containing 4 (VSIG4) to involve in the apoptosis of glioma and the sensitivity to temozolomide.
Rab27a was identified as a prognostic biomaker by mRNA profiling, correlated with malignant progression and subtype preference in gliomas.
Rab27b contributes to radioresistance and exerts a paracrine effect via epiregulin in glioblastoma.
Rab3 proteins and cancer: Exit strategies.
RAB38 confers a poor prognosis, associated with malignant progression and subtype preference in glioma.
Rab3a promotes brain tumor initiation and progression.
Rap2c as a Novel Biomarker for Predicting Poor Prognosis in Glioma.
Regulation of glioma migration and invasion via modification of Rap2a activity by the ubiquitin ligase Nedd4-1.
Remodeling cancer stemness by collagen/fibronectin via the AKT and CDC42 signaling pathway crosstalk in glioma.
Role of Rap1B and Tumor Suppressor PTEN in the Negative Regulation of Lysophosphatidic Acid-induced Migration by Isoproterenol in Glioma Cells.
Semaphorin 5A and plexin-B3 inhibit human glioma cell motility through RhoGDIalpha-mediated inactivation of Rac1 GTPase.
Slit2 inhibits glioma cell invasion in the brain by suppression of Cdc42 activity.
SNHG15 affects the growth of glioma microvascular endothelial cells by negatively regulating miR-153.
Synthesis and evaluation of bis-thiazole derivatives as new anticancer agents.
The guanine nucleotide exchange factors trio, Ect2, and Vav3 mediate the invasive behavior of glioblastoma.
The small GTPase Rac1 is involved in the maintenance of stemness and malignancies in glioma stem-like cells.
Three-dimensional patterning of multiple cell populations through orthogonal genetic control of cell motility.
TRPM7 Induces Mechanistic Target of Rap1b Through the Downregulation of miR-28-5p in Glioma Proliferation and Invasion.
Two novel genetic variants in the STK38L and RAB27A genes are associated with glioma susceptibility.
Versatile Role of Rab27a in Glioma: Effects on Release of Extracellular Vesicles, Cell Viability, and Tumor Progression.
Glomerulonephritis
C3G overexpression in glomerular epithelial cells during anti-GBM-induced glomerulonephritis.
Glomerulonephritis, Membranous
Role of guanine nucleotide exchange factor-H1 in complement-mediated RhoA activation in glomerular epithelial cells.
Glomerulosclerosis, Focal Segmental
Inverted formin 2-related Charcot-Marie-Tooth disease: extension of the mutational spectrum and pathological findings in Schwann cells and axons.
Rho-GTPase Activating Protein myosin MYO9A identified as a novel candidate gene for monogenic focal segmental glomerulosclerosis.
Glucose Intolerance
Insulin secretory deficiency and glucose intolerance in Rab3A null mice.
The adaptor protein APPL2 controls glucose-stimulated insulin secretion via F-actin remodeling in pancreatic ?-cells.
Goiter
H-RAS gene expression in human multinodular goiter.
Point mutations of ras and Gs alpha subunit genes in thyroid tumors.
Point mutations of ras oncogenes are an early event in thyroid tumorigenesis.
Goiter, Nodular
H-RAS 81 polymorphism is significantly associated with aneuploidy in follicular tumors of the thyroid.
H-RAS gene expression in human multinodular goiter.
Granuloma
Can K-ras codon 12 mutations be used to distinguish benign bile duct proliferations from metastases in the liver? A molecular analysis of 101 liver lesions from 93 patients.
Rubella vaccine-induced granulomas are a novel phenotype with incomplete penetrance of genetic defects in cytotoxicity.
Transforming growth factor beta1, ras and p53 in silica-induced fibrogenesis and carcinogenesis.
Granulomatous Disease, Chronic
Reconstitution of defective respiratory burst activity with partially purified human neutrophil cytochrome B in two genetic forms of chronic granulomatous disease: possible role of Rap1A.
Growth Hormone-Secreting Pituitary Adenoma
ras mutations in human prolactinomas and pituitary carcinomas.
Head and Neck Neoplasms
A transforming Kirsten ras oncogene in an oral squamous carcinoma.
Docetaxel suppresses invasiveness of head and neck cancer cells in vitro.
Drug Vulnerabilities and Disease Prognosis Linked to the Stem Cell-Like Gene Expression Program Triggered by the RHO GTPase Activator VAV2 in Hyperplastic Keratinocytes and Head and Neck Cancer.
Gain-of-function mutant p53 but not p53 deletion promotes head and neck cancer progression in response to oncogenic K-ras.
H-ras oncogene mutation and human papillomavirus infection in oral carcinomas.
Loss of heterozygosity and microsatellite instability of the h-ras gene in cancer of the head and neck.
Mutations in EGFR Signal Pathway in Correlation with Response to Treatment of Head and Neck Cancers.
Prevalence of K-ras Codon 12 Mutations in Indian Patients with Head and Neck Cancer.
[Clinical significance of K-RAS and cytokeratine 20 markers in diagnosis of lymphogenic metastasis of pancreatic cancer]
Hearing Loss, Noise-Induced
Noise-induced cochlear F-actin depolymerization is mediated via ROCK2/p-ERM signaling.
Heart Arrest
Global brain ischemia and reperfusion: modifications in eukaryotic initiation factors associated with inhibition of translation initiation.
Heart Diseases
Identification and association of RAC1 gene polymorphisms with mRNA and protein expression levels of Rac1 in solid organ (kidney, liver, heart) transplant recipients.
Role of Rac1-mineralocorticoid-receptor signalling in renal and cardiac disease.
Tinman/Nkx2-5 acts via miR-1 and upstream of Cdc42 to regulate heart function across species.
Heart Failure
Cdc42 is an antihypertrophic molecular switch in the mouse heart.
H-Ras Isoform Mediates Protection Against Pressure Overload-Induced Cardiac Dysfunction in Part Through Activation of AKT.
Hydrogen sulfide anion regulates redox signaling via electrophile sulfhydration.
Redox Signaling by 8-Nitro-cyclic Guanosine Monophosphate: Nitric Oxide- and Reactive Oxygen Species-Derived Electrophilic Messenger.
Rho-associated kinase modulates myocardial inflammatory cytokine responses.
Rnd3 haploinsufficient mice are predisposed to hemodynamic stress and develop apoptotic cardiomyopathy with heart failure.
Simvastatin activates the PPAR?-dependent pathway to prevent left ventricular hypertrophy associated with inhibition of RhoA signaling.
Small GTP-binding proteins and their regulators in cardiac hypertrophy.
[Establishment of a novel therapeutic strategy for heart failure based on the mechanism underlying maintenance of redox homeostasis by reactive sulfur species].
Hemangioma, Cavernous, Central Nervous System
CDC42 Deletion Elicits Cerebral Vascular Malformations via Increased MEKK3-Dependent KLF4 Expression.
KRIT1 association with the integrin-binding protein ICAP-1: a new direction in the elucidation of cerebral cavernous malformations (CCM1) pathogenesis.
miR-21 coordinates tumor growth and modulates KRIT1 levels.
Hemangiopericytoma
Cytogenetic, ras, and p53: studies in cases of canine neoplasms (hemangiopericytoma, mastocytoma, histiocytoma, chloroma).
Hemangiosarcoma
Chemical-specific alterations in ras, p53, and beta-catenin genes in hemangiosarcomas from B6C3F1 mice exposed to o-nitrotoluene or riddelliine for 2 years.
Comprehensive profiling of H-Ras signalling in angiosarcoma endothelium.
Final report on carcinogens background document for riddelliine.
Mutational status of K-ras and TP53 genes in primary sarcomas of the heart.
Mutations of ras protooncogenes and p53 tumor suppressor gene in cardiac hemangiosarcomas from B6C3F1 mice exposed to 1,3-butadiene for 2 years.
Hematologic Diseases
Rho GTPases in hematopoiesis and hemopathies.
Hematologic Neoplasms
Blocking oncogenic Ras signaling for cancer therapy.
Rho GTPases in hematopoiesis and hemopathies.
The pattern of mutational involvement of RAS genes in human hematologic malignancies determined by DNA amplification and direct sequencing.
[Characteristics of plasma DNA and its application for detection of K-ras gene mutation]
Hepatitis
Macrophage-derived extracellular vesicles regulate concanavalin A-induced hepatitis by suppressing macrophage cytokine production.
miR-203a is involved in HBx-induced inflammation by targeting Rap1a.
Hepatitis B
Applying Antibodies Inside Cells: Principles and Recent Advances in Neurobiology, Virology and Oncology.
Expression of oncogenes and tumor suppressor genes in human hepatocellular carcinoma and hepatoblastoma cell lines.
Functional analysis of miR-101-3p and Rap1b involved in hepatitis B virus-related hepatocellular carcinoma pathogenesis.
Hepatitis B Virus X Protein Stimulates Proliferation, Wound Closure and Inhibits Apoptosis of HuH-7 Cells via CDC42.
Hepatitis B virus X protein up-regulates oncogene Rab18 to result in the dysregulation of lipogenesis and proliferation of hepatoma cells.
Mechanisms of Huangqi Decoction Granules () on Hepatitis B Cirrhosis Patients Based on RNA-Sequencing.
Rac1 GTPase is activated by hepatitis B virus replication--involvement of HBX.
Small Interfering RNA Screening for the Small GTPase Rab Proteins Identifies Rab5B as a Major Regulator of Hepatitis B Virus Production.
[Pathogenesis of human cancer]
Hepatitis B, Chronic
Downregulation of serum RAB27B confers improved prognosis and is associated with hepatocellular carcinoma progression through PI3K-AKT-P21 signaling.
Hepatitis C
A single nucleotide polymorphism in activated cdc42 associated tyrosine kinase 1 influences the interferon therapy in hepatitis C patients.
Applying Antibodies Inside Cells: Principles and Recent Advances in Neurobiology, Virology and Oncology.
Differential Regulation of Lipoprotein and Hepatitis C Virus Secretion by Rab1b.
Hepatitis C virus core from two different genotypes has an oncogenic potential but is not sufficient for transforming primary rat embryo fibroblasts in cooperation with the H-ras oncogene.
Rab13 Is Involved in the Entry Step of Hepatitis C Virus Infection.
Rab18 binds to hepatitis C virus NS5A and promotes interaction between sites of viral replication and lipid droplets.
Rab18 is required for viral assembly of hepatitis C virus through trafficking of the core protein to lipid droplets.
Rab5 Enhances Classical Swine Fever Virus Proliferation and Interacts with Viral NS4B Protein to Facilitate Formation of NS4B Related Complex.
Supporting Role for GTPase Rab27a in Hepatitis C Virus RNA Replication through a Novel miR-122-Mediated Effect.
Hepatitis C, Chronic
Decreased apoptosis in advanced-stage/high-grade hepatocellular carcinoma complicating chronic hepatitis C is mediated through the downregulation of p21 ras.
Hepatoblastoma
Expression of oncogenes and tumor suppressor genes in human hepatocellular carcinoma and hepatoblastoma cell lines.
Genetic alterations in the Catnb gene but not the H-ras gene in hepatocellular neoplasms and hepatoblastomas of B6C3F(1) mice following exposure to diethanolamine for 2 years.
Low frequency of H-ras mutations in hepatocellular adenomas and carcinomas and in hepatoblastomas from B6C3F1 mice exposed to oxazepam in the diet.
Hermanski-Pudlak Syndrome
Analysis and expression of Rab38 in oculocutaneous lung disease.
Analysis of ocular hypopigmentation in Rab38cht/cht mice.
Combined deficiency of RAB32 and RAB38 in the mouse mimics Hermansky-Pudlak syndrome and critically impairs thrombosis.
Direct production of mouse disease models by embryo microinjection of TALENs and oligodeoxynucleotides.
Rab27a regulates the peripheral distribution of melanosomes in melanocytes.
RAB38 confers a poor prognosis, associated with malignant progression and subtype preference in glioma.
Rab38 Targets to Lamellar Bodies and Normalizes Their Sizes in Lung Alveolar Type II Epithelial Cells.
The regulation of platelet-dense granules by Rab27a in the ashen mouse, a model of Hermansky-Pudlak and Griscelli syndromes, is granule-specific and dependent on genetic background.
[Hypomelanoses transmitted from generation to generation].
Herpes Simplex
Activating the Expression of Human K-rasG12D Stimulates Oncogenic Transformation in Transgenic Goat Fetal Fibroblast Cells.
Development and analysis of a transformation-defective mutant of Harvey murine sarcoma tk virus and its gene product.
Impact of Rac1 and Cdc42 signaling during early herpes simplex virus type 1 infection of keratinocytes.
Rational screening of oligonucleotide combinatorial libraries for drug discovery.
Role of the small GTPase Rab27a during herpes simplex virus infection of oligodendrocytic cells.
Towards the application of Tc toxins as a universal protein translocation system.
Herpes Zoster
Liver X receptor activation enhances blood-brain barrier integrity in the ischemic brain and increases the abundance of ATP-binding cassette transporters ABCB1 and ABCC1 on brain capillary cells.
MicroRNA-15a - cell division cycle 42 signaling pathway in pathogenesis of pediatric inflammatory bowel disease.
The monomeric GTP binding protein, rab3a, is associated with the acrosome in mouse sperm.
Hirschsprung Disease
Quantitative Proteomics Reveals Association of Neuron Projection Development Genes ARF4, KIF5B, and RAB8A With Hirschsprung Disease.
Histiocytic Sarcoma
Infrequent activation of K-ras, H-ras, and other oncogenes in hepatocellular neoplasms initiated by methyl(acetoxymethyl)nitrosamine, a methylating agent, and promoted by phenobarbital in F344 rats.
Trametinib and Dabrafenib in histiocytic sarcoma transdifferentiated from chronic lymphocytic leukemia with a K-RAS and a unique BRAF mutation.
Histiocytoma, Benign Fibrous
Microsatellite and EGFR, HER2 and K-RAS analyses in sclerosing hemangioma of the lung.
Histiocytoma, Malignant Fibrous
H-ras oncogene mutation in dedifferentiated liposarcoma. Polymerase chain reaction-restriction fragment length polymorphism analysis.
Molecular analysis of p53, MDM2, and H-ras genes in osteosarcoma and malignant fibrous histiocytoma of bone in patients older than 40 years.
Primary malignant fibrous histiocytoma of the pancreas: a case with K-ras mutation and a review of the literature.
Histiocytosis, Langerhans-Cell
Enhanced expression of c-myc and H-ras oncogenes in Letterer-Siwe disease. A sequential study using colorimetric in situ hybridization.
HIV Infections
Cdc42 and RhoB activation are required for mannose receptor-mediated phagocytosis by human alveolar macrophages.
HIV signaling through CD4 and CCR5 activates Rho family GTPases that are required for optimal infection of primary CD4+ T cells.
Regulation of CXCR4 conformation by the small GTPase Rac1: implications for HIV infection.
Hodgkin Disease
A Novel CDC42 Mutation in an 11-Year Old Child Manifesting as Syndromic Immunodeficiency, Autoinflammation, Hemophagocytic Lymphohistiocytosis, and Malignancy: A Case Report.
Detection of activating mutations in the ras family genes in cytological specimens from lung-tumors.
Holoprosencephaly
Cdc42 deficiency causes Sonic hedgehog-independent holoprosencephaly.
Huntington Disease
A Large-scale Huntingtin Protein Interaction Network Implicates Rho GTPase Signaling Pathways in Huntington's Disease.
Deficient Rab11 activity underlies glucose hypometabolism in primary neurons of Huntington's disease mice.
Dendritic spine loss and neurodegeneration is rescued by Rab11 in models of Huntington's disease.
Disruption of Rab11 activity in a knock-in mouse model of Huntington's disease.
Rab11 as a modulator of synaptic transmission.
Rab11 rescues synaptic dysfunction and behavioural deficits in a Drosophila model of Huntington's disease.
The role of Rhes, Ras homolog enriched in striatum, in neurodegenerative processes.
Hydatidiform Mole
c-myc, c-erbB-2, c-fms and bcl-2 oncoproteins. Expression in normal placenta, partial and complete mole, and choriocarcinoma.
Hydrocephalus
Cdc42 deficiency causes ciliary abnormalities and cystic kidneys.
Conditional N-WASP knockout in mouse brain implicates actin cytoskeleton regulation in hydrocephalus pathology.
Inactivation of Cdc42 in embryonic brain results in hydrocephalus with ependymal cell defects in mice.
Myosin IXa Regulates Epithelial Differentiation and Its Deficiency Results in Hydrocephalus.
Hyperaldosteronism
Mutations of K-ras oncogene in human adrenal tumours in Taiwan.
Hyperalgesia
Botulinum toxin C3 inhibits hyperalgesia in mice with partial sciatic nerve injury.
Rab27a Contributes to the Processing of Inflammatory Pain in Mice.
Hypercholesterolemia
Simvastatin and ML141 Decrease Intracellular Streptococcus pyogenes Infection.
Statins inhibit HIV-1 infection by down-regulating Rho activity.
Hyperglycemia
Cdc42: A Novel Regulator of Insulin Secretion and Diabetes-Associated Diseases.
High glucose stimulates synthesis of fibronectin via a novel protein kinase C, Rap1b, and B-Raf signaling pathway.
Hyperglycemia promotes K-Ras-induced lung tumorigenesis through BASCs amplification.
Map4k4 Signaling Nodes in Metabolic and Cardiovascular Diseases.
miR-30c Mediates Upregulation of Cdc42 and Pak1 in Diabetic Cardiomyopathy.
ROCK-1 mediates diabetes-induced retinal pigment epithelial and endothelial cell blebbing: Contribution to diabetic retinopathy.
Translocation of H-Ras and its implications in the development of diabetic retinopathy.
Use of a fibrin-based system for enhancing angiogenesis and modulating inflammation in the treatment of hyperglycemic wounds.
Hyperhomocysteinemia
Rac1 GTPase Inhibition Blocked Podocyte Injury and Glomerular Sclerosis during Hyperhomocysteinemia via Suppression of Nucleotide-Binding Oligomerization Domain-Like Receptor Containing Pyrin Domain 3 Inflammasome Activation.
Hyperinsulinism
Fetal hyperinsulinemia increases farnesylation of p21 Ras in fetal tissues.
Hyperlipidemias
Rab8a Deficiency in Skeletal Muscle Causes Hyperlipidemia and Hepatosteatosis by Impairing Muscle Lipid Uptake and Storage.
Hyperpigmentation
Exogenous pyruvate alleviates UV-induced hyperpigmentation via restraining dendrite outgrowth and Rac1 GTPase activity.
Mosaic analysis and tumor induction in zebrafish by microsatellite instability-mediated stochastic gene expression.
Hypersensitivity
Adult neuronal Arf6 controls ethanol-induced behavior with Arfaptin downstream of Rac1 and RhoGAP18B.
Akt2 deficiency promotes cardiac induction of Rab4a and myocardial ?-adrenergic hypersensitivity.
Hypersensitivity of NIH3T3 cells transformed by H-ras gene to DNA-topoisomerase-I inhibitors.
Involvement of Golgi-associated retrograde protein complex in the recycling of the putative Dnf aminophospholipid flippases in yeast.
Rab37 is a novel mast cell specific GTPase localized to secretory granules.
Sumoylation of ABI5 by the Arabidopsis SUMO E3 ligase SIZ1 negatively regulates abscisic acid signaling.
Hypertension
Distinct Signaling Functions of Rap1 Isoforms in NO Release From Endothelium.
Fluoxetine inhibits monocrotaline-induced pulmonary arterial remodeling involved in inhibition of RhoA-Rho kinase and Akt signalling pathways in rats.
Identification of Novel Rho-Kinase-II Inhibitors with Vasodilatory Activity.
Inhibition of rho-associated kinase results in suppression of neointimal formation of balloon-injured arteries.
Involvement of Rho GTPases and their regulators in the pathogenesis of hypertension.
Rac1 GTPase in rodent kidneys is essential for salt-sensitive hypertension via a mineralocorticoid receptor-dependent pathway.
Rac1-Mediated Effects of HMG-CoA Reductase Inhibitors (Statins) in Cardiovascular Disease.
Regulation of Rho proteins by phosphorylation in the cardiovascular system.
Rho-kinase, a potential therapeutic target for the treatment of hypertension.
Role of Rac1 GTPase in salt-sensitive hypertension.
Ste20-related kinase SLK phosphorylates Ser188 of RhoA to induce vasodilation in response to angiotensin II Type 2 receptor activation.
Targeted genomic disruption of h-ras induces hypotension through a NO-cGMP-PKG pathway-dependent mechanism.
The effect of afterload and angiotensin II on proto-oncogene mRNA levels in the isolated working rat heart.
The kidney and hypertension: pathogenesis of salt-sensitive hypertension.
The Rho exchange factor Arhgef1 mediates the effects of angiotensin II on vascular tone and blood pressure.
[Involvement of small GTPase Rho and Rho-kinase in the pathogenesis of hypertension and hypertensive target organ damage]
Hypertension, Pulmonary
Prostacyclin does not inhibit rho-kinase: an implication for the treatment of pulmonary hypertension.
Hypertrophy, Left Ventricular
Simvastatin activates the PPAR?-dependent pathway to prevent left ventricular hypertrophy associated with inhibition of RhoA signaling.
Hypoglycemia
Signaling pathways involved in thrombin-induced cell protection.
Hypopigmentation
A novel RAB27A mutation in a patient with Griscelli syndrome type 2.
Pulmonary lymphomatoid granulomatosis in Griscelli syndrome type 2.
Rab GTPases: key players in melanosome biogenesis, transport, and transfer.
The regulation of platelet-dense granules by Rab27a in the ashen mouse, a model of Hermansky-Pudlak and Griscelli syndromes, is granule-specific and dependent on genetic background.
Hypotension
Targeted genomic disruption of h-ras induces hypotension through a NO-cGMP-PKG pathway-dependent mechanism.
Hypothyroidism
Nutritional, hormonal, and depot-dependent regulation of the expression of the small GTPase Rab18 in rodent adipose tissue.
Pathogenetic basis of Takenouchi-Kosaki syndrome: Electron microscopy study using platelets in patients and functional studies in a Caenorhabditis elegans model.
Regulation by thyroid status of c-myc, c-fos and H-ras mRNAs in the rat myocardium.
Synaptic and Non-Synaptic Mitochondria in Hippocampus of Adult Rats Differ in Their Sensitivity to Hypothyroidism.
Idiopathic Pulmonary Fibrosis
Downregulation of FAK-related non-kinase mediates the migratory phenotype of human fibrotic lung fibroblasts.
Immune System Diseases
A Griscelli syndrome type 2 murine model of hemophagocytic lymphohistiocytosis (HLH).
Biochemical and functional characterization of Rab27a mutations occurring in Griscelli syndrome patients.
Characterization of a cdc42 protein inhibitor and its use as a molecular probe.
Infarction, Middle Cerebral Artery
Liver X receptor activation enhances blood-brain barrier integrity in the ischemic brain and increases the abundance of ATP-binding cassette transporters ABCB1 and ABCC1 on brain capillary cells.
Infections
"Low-risk" and "high-risk" HPV-infection and K-ras gene point mutations in human cervical cancer: a study of 31 cases.
A Cdc42 homolog in Colletotrichum gloeosporioides regulates morphological development and is required for ROS-mediated plant infection.
A combinatorial approach for selectively inducing programmed cell death in human pancreatic cancer cells.
A dominant negative mutant of rab5 inhibits infection of cells by foot-and-mouth disease virus; implications for virus entry.
A human vascular endothelial cell model to study angiogenesis and tumorigenesis.
A Novel CDC42 Mutation in an 11-Year Old Child Manifesting as Syndromic Immunodeficiency, Autoinflammation, Hemophagocytic Lymphohistiocytosis, and Malignancy: A Case Report.
A Peptide Derived from Phosphoinositide 3-kinase Inhibits Endocytosis and Influenza Virus Infection.
A Rac1 GTPase is a critical factor in the immune response of shrimp (Litopenaeus vannamei) to Vibrio alginolyticus infection.
Actin pedestal formation by enteropathogenic Escherichia coli is regulated by IQGAP1, calcium, and calmodulin.
Actions of Rab27B-GTPase on mammalian central excitatory synaptic transmission.
Activation of hypersensitive response genes in the absence of pathogens in transgenic tobacco plants expressing a rice small GTPase.
Adeno-associated virus 2 infection requires endocytosis through the CLIC/GEEC pathway.
Altered ganglioside expression in ras-oncogene-transformed cells.
Alternative endocytosis pathway for productive entry of hepatitis C virus.
Analysis and clinical implications of K-ras gene mutations and infection with human papillomavirus types 16 and 18 in primary adenocarcinoma of the uterine cervix.
Analysis of Chlamydia caviae entry sites and involvement of Cdc42 and Rac activity.
Analysis of human immunodeficiency virus type 1 promoter insertion in vivo.
Analysis of p53, K-ras gene mutation & Helicobacter pylori infection in patients with gastric cancer & peptic ulcer disease at a tertiary care hospital in north India.
Analysis of the proteins synthesized in ultraviolet light-irradiated Escherichia coli following infection with the bacteriophages lambdadrifd 18 and lambdadfus-3.
Analysis of the Rac/Rop small GTPase family in rice: expression, subcellular localization and role in disease resistance.
Arabidopsis RAB8A, RAB8B, and RAB8D Proteins Interact with Several RTNLB Proteins and Are Involved in the Agrobacterium tumefaciens Infection Process.
Beyond Rab GTPases Legionella activates the small GTPase Ran to promote microtubule polymerization, pathogen vacuole motility, and infection.
Beyond Rab GTPases: Legionella activates the small GTPase Ran to promote microtubule polymerization, pathogen vacuole motility, and infection.
Bombyx mori nucleopolyhedrovirus utilizes a clathrin and dynamin dependent endocytosis entry pathway into BmN cells.
Borrelia burgdorferi elongation factor EF-Tu is an immunogenic protein during Lyme borreliosis.
Burkholderia cenocepacia infection: Disruption of phagocyte immune functions through Rho GTPase inactivation.
Cag pathogenicity island-specific responses of gastric epithelial cells to Helicobacter pylori infection.
Caprine humoral response to Burkholderia pseudomallei antigens during acute melioidosis from aerosol exposure.
CD81 is a central regulator of cellular events required for hepatitis C virus infection of human hepatocytes.
Cdc42 - A tryst between host cholesterol metabolism and infection.
Cdc42 and the Rho GEF intersectin-1 collaborate with Nck to promote N-WASP-dependent actin polymerisation.
Cdc42 promotes host defenses against fatal infection.
Cdc42 stimulates neurite outgrowth and formation of growth cone filopodia and lamellipodia.
Cell Entry of Avian Reovirus Follows a Caveolin-1-mediated and Dynamin-2-dependent Endocytic Pathway That Requires Activation of p38 Mitogen-activated Protein Kinase (MAPK) and Src Signaling Pathways as Well as Microtubules and Small GTPase Rab5 Protein.
Cell lines containing and expressing the human herpesvirus 6A ts gene are protected from both H-ras and BPV-1 transformation.
Characterization of human astrovirus cell entry.
Cholera toxin disrupts barrier function by inhibiting exocyst-mediated trafficking of host proteins to intestinal cell junctions.
Cloning and Activity Analysis of Promoter of RanGTPase Gene from Shrimp, Marsupenaeus japonicus
Coexistence of K-ras mutations and HPV infection in colon cancer.
Conformational control of small GTPases by AMPylation.
Constitutive resistance to viral infection in human CD141(+) dendritic cells.
cPLA2 regulates the expression of type I interferons and intracellular immunity to Chlamydia trachomatis.
Cyclophilin A is secreted by a vesicular pathway in vascular smooth muscle cells.
Cyclophilin function in Cancer; lessons from virus replication.
Detection of hepatitis-B virus-DNA and mutations in k-ras and p53 genes in human hepatocellular carcinomas.
Detection of human papilloma virus (HPV) and K-ras mutations in human lung carcinomas.
Differentiating Staphylococcus aureus from Escherichia coli mastitis: S. aureus triggers unbalanced immune-dampening and host cell invasion immediately after udder infection.
Differentiation of PC12 cells with K-ras: comparison with nerve growth factor.
Disruption of epithelial barrier integrity by Salmonella enterica serovar typhimurium requires geranylgeranylated proteins.
Dot/Icm Effector Translocation by Legionella longbeachae Creates a Replicative Vacuole Similar to That of Legionella pneumophila despite Translocation of Distinct Effector Repertoires.
Downregulation of serum RAB27B confers improved prognosis and is associated with hepatocellular carcinoma progression through PI3K-AKT-P21 signaling.
Drosophila melanogaster S2 cells: a model system to study Chlamydia interaction with host cells.
Early herpes simplex virus type 1 infection is dependent on regulated Rac1/Cdc42 signalling in epithelial MDCKII cells.
Effect of the Rho GTPase inhibitor-1 on the entry of dengue serotype 2 virus into EAhy926 cells.
Endocytic Rabs Are Recruited to the Trypanosoma cruzi Parasitophorous Vacuole and Contribute to the Process of Infection in Non-professional Phagocytic Cells.
Enterohaemorrhagic E. coli modulates an ARF6:Rab35 signaling axis to prevent recycling endosome maturation during infection.
Enzymatically active Rho and Rac small-GTPases are involved in the establishment of the vacuolar membrane after Toxoplasma gondii invasion of host cells.
Epithelial chemokine CXCL14 synergizes with CXCL12 via allosteric modulation of CXCR4.
Equine Alphaherpesviruses Require Activation of the Small GTPases Rac1 and Cdc42 for Intracellular Transport.
Expression of oncogenic alleles induces multiple blocks to HCMV infection.
FgMon1, a guanine nucleotide exchange factor of FgRab7, is important for vacuole fusion, autophagy and plant infection in Fusarium graminearum.
Gene editing a constitutively active OsRac1 by homologous recombination-based gene targeting induces immune responses in rice.
Golgi-Resident GTPase Rab30 Promotes the Biogenesis of Pathogen-Containing Autophagosomes.
Graf1 controls the growth of human parainfluenza virus type 2 through inactivation of RhoA signaling.
Growth inhibitory effect of anti-K-ras adenovirus on lung cancer cells.
H-ras infection in mink lung epithelial cells may induce "atypical" multidrug resistance.
Hepatocarcinogenesis in mice with beta-catenin and Ha-ras gene mutations.
Herpes Simplex Virus Entry by a Nonconventional Endocytic Pathway.
High-level expression of H-ras and c-myc oncogenes in mycoplasma-mediated malignant cell transformation.
Identification and characterization of a novel broad spectrum virus entry inhibitor.
Identification and cloning of two immunogenic Clostridium perfringens proteins, elongation factor Tu (EF-Tu) and pyruvate:ferredoxin oxidoreductase (PFO) of C. perfringens.
Identification and functional analysis of inflammation-related miRNAs in skin wound repair.
Identification of a Role for the trans-Golgi Network in Human Papillomavirus 16 Pseudovirus Infection.
Identification of cognate host targets and specific ubiquitylation sites on the Salmonella SPI-1 effector SopB/SigD.
Identification of host trafficking genes required for HIV-1 virological synapse formation in dendritic cells.
Identification of Rab18 as an Essential Host Factor for BK Polyomavirus Infection Using a Whole-Genome RNA Interference Screen.
Identification of Rab27a as a host factor for oncolytic herpes virus susceptibility to tumor cells.
Immune evasion by Salmonella: exploiting the VPAC1/VIP axis in human monocytes.
Immunogenicity and protective capacity of EF-Tu and FtsZ of Streptococcus suis serotype 2 against lethal infection.
Impact of Rac1 and Cdc42 signaling during early herpes simplex virus type 1 infection of keratinocytes.
Infection: UPEC subverts endosomal recycling by modulating Rab35.
Influenza A virus progeny vRNP trafficking in live infected cells studied with the virus-encoded fluorescently tagged PB2 protein.
Influenza A virus ribonucleoproteins modulate host recycling by competing with Rab11 effectors.
Inhibition of CD40-induced N-Ras activation reduces leishmania major infection.
Inhibition of Cdc42-dependent signalling in Saccharomyces cerevisiae by phosphatase-dead SigD/SopB from Salmonella typhimurium.
Interrelationship between the expression of h-ras p21, C-myc and p53 proteins, and the infection of high-risk human papillomaviruses in Japanese patients with esophageal squamous-cell carcinoma.
Intracellular Uropathogenic E. coli Exploits Host Rab35 for Iron Acquisition and Survival within Urinary Bladder Cells.
Intraperitoneal injection of adenovirus expressing antisense K-ras RNA suppresses peritoneal dissemination of hamster syngeneic pancreatic cancer without systemic toxicity.
IQGAP1 regulates salmonella invasion through interactions with actin, Rac1, and Cdc42.
K-ras Mutation Targeted to Gastric Tissue Progenitor Cells Results in Chronic Inflammation, an Altered Microenvironment, and Progression to Intraepithelial Neoplasia.
K-ras mutations and cell kinetics in Helicobacter pylori associated gastric intestinal metaplasia: a comparison before and after eradication in patients with chronic gastritis and gastric cancer.
Kaposi's sarcoma associated herpes virus (KSHV) induced COX-2: a key factor in latency, inflammation, angiogenesis, cell survival and invasion.
KSHV Entry and Trafficking in Target Cells-Hijacking of Cell Signal Pathways, Actin and Membrane Dynamics.
Lack of p53 and ras mutations in Helicobacter hepaticus-induced liver tumors in A/JCr mice.
Legionella pneumophila infection is enhanced in a RacH-null mutant of Dictyostelium.
Leishmania donovani infection differentially regulates small G-proteins.
Macropinocytotic uptake and infection of human epithelial cells with species B2 adenovirus type 35.
Major Host Factors Involved in Epithelial Cell Invasion of Campylobacter jejuni: Role of Fibronectin, Integrin Beta1, FAK, Tiam-1, and DOCK180 in Activating Rho GTPase Rac1.
Membrane trafficking RNA interference screen identifies a crucial role of the clathrin endocytic pathway and ARP2/3 complex for Japanese encephalitis virus infection in HeLa cells.
Metformin impairs Rho GTPase signaling to induce apoptosis in neuroblastoma cells and inhibits growth of tumors in the xenograft mouse model of neuroblastoma.
MiR-199a Inhibits Secondary Envelopment of Herpes Simplex Virus-1 Through the Downregulation of Cdc42-specific GTPase Activating Protein Localized in Golgi Apparatus.
Modulation of cis- and trans- Golgi and the Rab9A-GTPase during infection by Besnoitia besnoiti, Toxoplasma gondii and Neospora caninum.
Modulation of Rab GTPase function by a protein phosphocholine transferase.
Molecular cloning and characterization of Ras- and Raf-homologues from the fox-tapeworm Echinococcus multilocularis.
Mouse hepatitis coronavirus RNA replication depends on GBF1-mediated ARF1 activation.
Mutant RBL mast cells defective in Fc epsilon RI signaling and lipid raft biosynthesis are reconstituted by activated Rho-family GTPases.
Mycoplasma infection suppresses p53, activates NF-kappaB and cooperates with oncogenic Ras in rodent fibroblast transformation.
NSC23766 and Ehop016 Suppress Herpes Simplex Virus-1 Replication by Inhibiting Rac1 Activity.
Overexpression of microRNA-133b reduces myocardial injuries in children with viral myocarditis by targeting Rab27B gene.
Overexpression of vascular endothelial growth factor isoforms drives oxygenation and growth but not progression to glioblastoma multiforme in a human model of gliomagenesis.
Pancytopenia, Recurrent Infection, Poor Wound Healing, Heterotopia of the Brain Probably Associated with A Candidate Novel de Novo CDC42 Gene Defect: Expanding the Molecular and Phenotypic Spectrum.
Pathogenetic basis of Takenouchi-Kosaki syndrome: Electron microscopy study using platelets in patients and functional studies in a Caenorhabditis elegans model.
Pathogenicity island-dependent activation of Rho GTPases Rac1 and Cdc42 in Helicobacter pylori infection.
Phosphatidylinositol 3-kinase and frabin mediate Cryptosporidium parvum cellular invasion via activation of Cdc42.
Presence of ras oncogene mutations and human papillomavirus DNA in human prostate carcinomas.
Progressive decline of T and B cell numbers and function in a patient with CDC42 deficiency.
rAAV2 traffics through both the late and the recycling endosomes in a dose-dependent fashion.
Rab GTPases implicated in inherited and acquired disorders.
Rab13 Is Involved in the Entry Step of Hepatitis C Virus Infection.
Rab18 Facilitates Dengue Virus Infection by Targeting Fatty Acid Synthase to Sites of Viral Replication.
Rab1b-GBF1-ARFs mediated intracellular trafficking is required for classical swine fever virus replication in swine umbilical vein endothelial cells.
Rab27a facilitates human parainfluenza virus type 2 growth by promoting cell surface transport of envelope proteins.
Rab27a is essential for the formation of neutrophil extracellular traps (NETs) in neutrophil-like differentiated HL60 cells.
Rab27a is required for human cytomegalovirus assembly.
Rab27b regulates extracellular vesicle production in cells infected with Kaposi's sarcoma-associated herpesvirus to promote cell survival and persistent infection.
Rab5 and Rab11 Are Required for Clathrin-Dependent Endocytosis of Japanese Encephalitis Virus in BHK-21 Cells.
Rab5 and Rab7, but not ARF6, govern the early events of HIV-1 infection in polarized human placental cells.
Rab5 Enhances Classical Swine Fever Virus Proliferation and Interacts with Viral NS4B Protein to Facilitate Formation of NS4B Related Complex.
Rac GTPases in human diseases.
Rac1 and Cdc42 GTPases cross-talk regulates formation of filopodia required for Dengue virus type-2 entry into HMEC-1 cells.
Rac1-dependent endocytosis and Rab5-dependent intracellular trafficking are required by Enterovirus A71 and Coxsackievirus A10 to establish infections.
Rac2 is a major actor of Drosophila resistance to Pseudomonas aeruginosa acting in phagocytic cells.
RalF-Mediated Activation of Arf6 Controls Rickettsia typhi Invasion by Co-Opting Phosphoinositol Metabolism.
Ras isoforms selectively regulate antigen-specific immune response.
Real-time imaging of Leishmania mexicana-infected early phagosomes: a study using primary macrophages generated from green fluorescent protein-Rab5 transgenic mice.
Recycling Endosomes and Viral Infection.
Regulation of small GTPases by GEFs, GAPs, and GDIs.
RhoA signaling is required for respiratory syncytial virus-induced syncytium formation and filamentous virion morphology.
RhoGTPase activation is a key step in renal epithelial mesenchymal transdifferentiation.
Role of the small GTPase Rab27a during herpes simplex virus infection of oligodendrocytic cells.
Roles of small GTPase Rac1 in the regulation of actin cytoskeleton during dengue virus infection.
Rsr1 Palmitoylation and GTPase Activity Status Differentially Coordinate Nuclear, Septin, and Vacuole Dynamics in Candida albicans.
Salmon cells SHK-1 internalize infectious pancreatic necrosis virus by macropinocytosis.
SAP and XIAP deficiency in hemophagocytic lymphohistiocytosis.
Silencing of the Rac1 GTPase MtROP9 in Medicago truncatula stimulates early mycorrhizal and oomycete root colonizations but negatively affects rhizobial infection.
Small GTPase Immunity-Associated Proteins Mediate Resistance to Toxoplasma gondii Infection in Lewis Rat.
Small GTPase Rab8a-recruited Phosphatidylinositol 3-Kinase ? Regulates Signaling and Cytokine Outputs from Endosomal Toll-like Receptors.
Small Molecule Inhibitors Limit Endothelial Cell Invasion by Staphylococcus aureus.
Soft-shelled turtle iridovirus enters cells via cholesterol-dependent, clathrin-mediated endocytosis as well as macropinocytosis.
Statins disrupt CCR5 and RANTES expression levels in CD4+ T lymphocytes in vitro and preferentially decrease infection of R5 versus X4 HIV-1.
Structural basis for RNA-genome recognition during bacteriophage Q? replication.
Structure of the Qbeta replicase, an RNA-dependent RNA polymerase consisting of viral and host proteins.
Study on the association between Helicobacter pylori infection and the pathogenesis of gastric cancer by using molecular biological techniques.
Substrate recognition by the Pseudomonas aeruginosa EF-Tu-modifying methyltransferase EftM.
Suppression of PmRab11 inhibits YHV infection in Penaeus monodon.
Temporal regulation of salmonella virulence effector function by proteasome-dependent protein degradation.
The autophagic pathway is actively modulated by phase II Coxiella burnetii to efficiently replicate in the host cell.
The cytotoxin YopT of Yersinia enterocolitica induces modification and cellular redistribution of the small GTP-binding protein RhoA.
The Differential Expression and Possible Function of Long Noncoding RNAs in Liver Cells Infected by Dengue Virus.
The dual action of poly(ADP-ribose) polymerase -1 (PARP-1) inhibition in HIV-1 infection: HIV-1 LTR inhibition and diminution in Rho GTPase activity.
The Early Secretory Pathway Contributes to the Growth of the Coxiella-replicative Niche.
The GTPase Rab4 interacts with Chlamydia trachomatis inclusion membrane protein CT229.
The Hematopoietic Cell-Specific Rho GTPase Inhibitor ARHGDIB/D4GDI Limits HIV Type 1 Replication.
The interplay between the Escherichia coli Rho guanine nucleotide exchange factor effectors and the mammalian RhoGEF inhibitor EspH.
The late endocytic Rab39a GTPase regulates the interaction between multivesicular bodies and chlamydial inclusions.
The monomeric GTPase RabA2 is required for progression and maintenance of membrane integrity of infection threads during root nodule symbiosis.
The Mycobacterium avium subsp. paratuberculosis MAP3464 gene encodes an oxidoreductase involved in invasion of bovine epithelial cells through the activation of host cell Cdc42.
The open reading frame 3a protein of severe acute respiratory syndrome-associated coronavirus promotes membrane rearrangement and cell death.
The Ras/Rac1/Cdc42/SEK/JNK/c-Jun cascade is a key pathway by which agonists stimulate DNA synthesis in primary cultures of rat hepatocytes.
The Salmonella Effector SseK3 Targets Small Rab GTPases.
The small G protein H-Ras in the mesolimbic system is a molecular gateway to alcohol-seeking and excessive drinking behaviors.
The small GTPase NtRHO1 negatively regulates tobacco defense response to Tobacco mosaic virus by interacting with NtWRKY50.
The Small GTPase Rab5c Exerts Bi-Function in Singapore Grouper Iridovirus Infections and Cellular Responses in the Grouper, Epinephelus coioides.
The small GTPases Rab9A and Rab23 function at distinct steps in autophagy during Group A Streptococcus infection.
Time-resolved proteomics of adenovirus infected cells.
Tuning of in vivo cognate B-T cell interactions by Intersectin 2 is required for effective anti-viral B cell immunity.
Two closely related Rho GTPases, Cdc42 and RacA, of the en-dophytic fungus Epichloë festucae have contrasting roles for ROS production and symbiotic infection synchronized with the host plant.
Ubiquitination-Dependent Regulation of Small GTPases in Membrane Trafficking: From Cell Biology to Human Diseases.
Unveiling ubiquitinome rearrangements induced by Salmonella infection.
Vibrio parahaemolyticus Infection Influenced Trace Element Homeostasis, Impaired Antioxidant Function, and Induced Inflammation Response in Litopenaeus vannamei.
[Evaluation of K-ras 12 oncogene mutations in Venezuelan patients with Helicobacter pylori infection]
[Express of human papillomavirus, P53 and H-ras gene in laryngeal cancer]
[HMGB1-a as potential target for therapy of hematological malignancies].
[Oncogenes and cancer of the larynx. EGFR, p21 ras and HPV-DNA infections]
[The roles of H. pylori infection and K-ras gene mutation in gastric carcinogenesis]
Infertility
Alterations in seminal plasma proteomic profile in men with primary and secondary infertility.
CDC42 controls the activation of primordial follicles by regulating PI3K signaling in mouse oocytes.
Rab11 is essential for fertility in Drosophila.
Infertility, Female
Specific deletion of Cdc42 does not affect meiotic spindle organization/migration and homologous chromosome segregation but disrupts polarity establishment and cytokinesis in mouse oocytes.
Inflammatory Bowel Diseases
Analysis of mutations in TP53, APC, K-ras, and DCC genes in the non-dysplastic mucosa of patients with inflammatory bowel disease.
Dislocation of Rab13 and vasodilator-stimulated phosphoprotein in inactive colon epithelium in patients with Crohn's disease.
Identification of subjects at risk for colorectal carcinoma through a test based on K-ras determination in the stool.
Increased etheno-DNA adducts in affected tissues of patients suffering from Crohn's disease, ulcerative colitis, and chronic pancreatitis.
K-ras mutations in sera of patients with colorectal neoplasias and long-standing inflammatory bowel disease.
Kruppel-like factor 6 (KLF6) is a tumor-suppressor gene frequently inactivated in colorectal cancer.
Mice lacking myosin IXb, an inflammatory bowel disease susceptibility gene, have impaired intestinal barrier function and superficial ulceration in the ileum.
New insights into the interplay between autophagy, gut microbiota and inflammatory responses in IBD.
Rac Attack: Modulation of the Small GTPase Rac in Inflammatory Bowel Disease and Thiopurine Therapy.
Screening for p53 and K-ras mutations in whole-gut lavage in chronic inflammatory bowel disease.
Influenza, Human
A Comprehensive Review on the Interaction Between the Host GTPase Rab11 and Influenza A Virus.
A Peptide Derived from Phosphoinositide 3-kinase Inhibits Endocytosis and Influenza Virus Infection.
A Rab11 and microtubule dependent mechanism for cytoplasmic transport of influenza A virus vRNA.
Binding of ras oncogene peptides to purified HLA-DQ(alpha 1*0102,beta 1*0602) and -DR(alpha,beta 1*0101) molecules.
Binding of the influenza virus NS1 protein to double-stranded RNA inhibits the activation of the protein kinase that phosphorylates the elF-2 translation initiation factor.
Clustering of Rab11 vesicles in influenza A virus infected cells creates hotspots containing the 8 viral ribonucleoproteins.
Clustering of raft-associated proteins in the external membrane leaflet modulates internal leaflet h-ras diffusion and signaling.
Fluorescent protein-based biosensors to visualize signal transduction beneath the plasma membrane.
Influenza A virus ribonucleoproteins modulate host recycling by competing with Rab11 effectors.
On the role of electrostatic interactions in the design of protein-protein interfaces.
Role of the Rab11 pathway in negative-strand virus assembly.
The Rab11 pathway is required for influenza A viral budding and filament formation.
The Rac1 inhibitor NSC23766 exerts anti-influenza virus properties by affecting the viral polymerase complex activity.
Transport of influenza A virus neuraminidase (NA) to host cell surface is regulated by ARHGAP21 and Cdc42.
YRKL sequence of influenza virus M1 functions as the L domain motif and interacts with VPS28 and Cdc42.
[Mechanism underlying the anterograde transport of the influenza A virus transmembrane proteins and genome in host cytoplasm].
Insulin Resistance
IFN-?/mTORC1 decreased Rab11 in Schwann cells of diabetic peripheral neuropathy, inhibiting cell proliferation via GLUT1 downregulation.
Map4k4 Signaling Nodes in Metabolic and Cardiovascular Diseases.
Metformin Decreases Insulin Resistance in Type 1 Diabetes Through Regulating P53 and RAP2A in vitro and in vivo [Retraction].
Metformin Decreases Insulin Resistance in Type 1 Diabetes Through Regulating p53 and RAP2A in vitro and in vivo.
Rac1 muscle knockout exacerbates the detrimental effect of high-fat diet on insulin-stimulated muscle glucose uptake independently of Akt.
Insulinoma
Analysis of selected genes in neuroendocrine tumours: insulinomas and phaeochromocytomas.
Co-deletions of the retinoblastoma gene and Wilms' tumor gene and rearrangement of the Krev-1 gene in a human insulinoma.
Expression of the ras-related rab3a gene in human insulinomas and normal human pancreatic islets.
ICA69 is a novel Rab2 effector regulating ER-Golgi trafficking in insulinoma cells.
Molecular genetics of malignant insulinoma.
Rab8a is involved in membrane trafficking of Kir6.2 in the MIN6 insulinoma cell line.
Rap1 promotes multiple pancreatic islet cell functions and signals through mTOR complex 1 to enhance proliferation.
[Alteration of the K-ras and p16/CDKN2 gene in endocrine pancreatic carcinomas]
[K-ras mutation in pancreatic juice from patients with pancreatic carcinoma]
Intellectual Disability
Alteration of synaptic network dynamics by the intellectual disability protein PAK3.
Cerebral organoid and mouse models reveal a RAB39b-PI3K-mTOR pathway-dependent dysregulation of cortical development leading to macrocephaly/autism phenotypes.
Costello syndrome H-Ras alleles regulate cortical development.
CYFIP/Sra-1 controls neuronal connectivity in Drosophila and links the Rac1 GTPase pathway to the fragile X protein.
De novo mutations in the GTP/GDP-binding region of RALA, a RAS-like small GTPase, cause intellectual disability and developmental delay.
Dendritic spine abnormalities in mental retardation.
Diverse roles of Rho family GTPases in neuronal development, survival, and death.
Dysregulation of Rho GTPases in the ?Pix/Arhgef6 mouse model of X-linked intellectual disability is paralleled by impaired structural and synaptic plasticity and cognitive deficits.
Exon 21 deletion in the OPHN1 gene in a family with syndromic X-linked intellectual disability: Case report.
From fragile X mental retardation protein to Rac1 GTPase: new insights from Fly CYFIP.
Impairment of fragile X mental retardation protein-metabotropic glutamate receptor 5 signaling and its downstream cognates ras-related C3 botulinum toxin substrate 1, amyloid beta A4 precursor protein, striatal-enriched protein tyrosine phosphatase, and homer 1, in autism: a postmortem study in cerebellar vermis and superior frontal cortex.
LRCH1 interferes with DOCK8-Cdc42-induced T cell migration and ameliorates experimental autoimmune encephalomyelitis.
Neuropathophysiological significance of the c.1449T>C/p.(Tyr64Cys) mutation in the CDC42 gene responsible for Takenouchi-Kosaki syndrome.
p21-activated kinase-aberrant activation and translocation in Alzheimer disease pathogenesis.
Pathogenetic basis of Takenouchi-Kosaki syndrome: Electron microscopy study using platelets in patients and functional studies in a Caenorhabditis elegans model.
Pharmacological rescue of adult hippocampal neurogenesis in a mouse model of X-linked intellectual disability.
Platelet lamellipodium formation is not required for thrombus formation and stability.
Rab23 and developmental disorders.
Rho GTPase signaling at the synapse: Implications for intellectual disability.
Rho GTPases in Intellectual Disability: From Genetics to Therapeutic Opportunities.
ROCK/PKA inhibition rescues hippocampal hyperexcitability and GABAergic neuron alterations in Oligophrenin-1 Knock-out mouse model of X-linked intellectual disability.
The novel Rho-GTPase activating gene MEGAP/ srGAP3 has a putative role in severe mental retardation.
The Xq22 inversion breakpoint interrupted a novel Ras-like GTPase gene in a patient with Duchenne muscular dystrophy and profound mental retardation.
Two knockdown models of the autism genes SYNGAP1 and SHANK3 in zebrafish produce similar behavioral phenotypes associated with embryonic disruptions of brain morphogenesis.
Variants in the RAB3A gene are not associated with mental retardation in the Chinese population.
Intestinal Neoplasms
Detection of K-ras gene mutation in fecal samples from elderly large intestinal cancer patients and its diagnostic significance.
Targeted expression of oncogenic K-ras in intestinal epithelium causes spontaneous tumorigenesis in mice.
TGF-? acts as a dual regulator of COX-2/PGE2 tumor promotion depending of its cross-interaction with H-Ras and Wnt/?-catenin pathways in colorectal cancer cells.
Intestinal Polyposis
KLF5 mediates the hyper-proliferative phenotype of the intestinal epithelium in mice with intestine-specific endogenous K-RasG12D expression.
Irritable Bowel Syndrome
Genetic variants in CDC42 and NXPH1 as susceptibility factors for constipation and diarrhoea predominant irritable bowel syndrome.
Ischemic Attack, Transient
Disturbances of calcium homeostasis within the endoplasmic reticulum may contribute to the development of ischemic-cell damage.
Ischemic Stroke
Activation of endothelial ras-related C3 botulinum toxin substrate 1 (Rac1) improves post-stroke recovery and angiogenesis via activating Pak1 in mice.
Increased leukocyte ROCK activity in patients after acute ischemic stroke.
Neuronal Rho GTPase Rac1 elimination confers neuroprotection in a mouse model of permanent ischemic stroke.
Small GTPase RhoA and its effector rho kinase mediate oxygen glucose deprivation-evoked in vitro cerebral barrier dysfunction.
SVCT2 Promotes Neural Stem/Progenitor Cells Migration Through Activating CDC42 After Ischemic Stroke.
Joint Diseases
H-ras oncogene point mutations in arthritic synovium.
Keratoacanthoma
Differential expression of the H-ras mutated and normal alleles in rabbit DMBA-induced keratoacanthomas.
H-ras activation in benign and self-regressing skin tumors (keratoacanthomas) in both humans and an animal model system.
Increased incidence of squamous cell carcinomas in Mastomys natalensis papillomavirus E6 transgenic mice during two-stage skin carcinogenesis.
Oncogene involvement in tumor regression: H-ras activation in the rabbit keratoacanthoma model.
ras activation in human tumors and in animal model systems.
Kidney Diseases
A Point Mutation in p190A RhoGAP Affects Ciliogenesis and Leads to Glomerulocystic Kidney Defects.
Cdc42 deficiency induces podocyte apoptosis by inhibiting the Nwasp/stress fibers/YAP pathway.
Modification of mineralocorticoid receptor function by Rac1 GTPase: implication in proteinuric kidney disease.
Podocyte-specific Rac1 deficiency ameliorates podocyte damage and proteinuria in STZ-induced diabetic nephropathy in mice.
Rab27a dependent exosome releasing participated in albumin handling as a coordinated approach to lysosome in kidney disease.
Rac1 activation in podocytes induces the spectrum of nephrotic syndrome.
Rac1 GTPase in rodent kidneys is essential for salt-sensitive hypertension via a mineralocorticoid receptor-dependent pathway.
Kidney Diseases, Cystic
Aberrant regulation of planar cell polarity in polycystic kidney disease.
Cdc42 deficiency causes ciliary abnormalities and cystic kidneys.
Kidney Failure, Chronic
Genetic susceptibility of hypertension-induced kidney disease.
RhoA, Rho kinase, JAK2, and STAT3 may be the intracellular determinants of longevity implicated in the progeric influence of obesity: Insulin, IGF-1, and leptin may all conspire to promote stem cell exhaustion.
Kidney Neoplasms
Chromosomal abnormalities and gene amplification in renal cancers induced in rats by nickel subsulfide.
Evidence for aldosterone-dependent growth of renal cell carcinoma.
Heme oxygenase-1 is overexpressed in human renal cancer cells following activation of the Ras-Raf-ERK Pathway, and mediates anti-apoptotic signal.
Prostaglandin E2 regulates renal cell carcinoma invasion through a EP4-Rap signal transduction pathway.
Rap2a serves as a potential prognostic indicator of renal cell carcinoma and promotes its migration and invasion through up-regulating p-Akt.
Rho GTPase Activating Protein 24 (ARHGAP24) Silencing Promotes Lung Cancer Cell Migration and Invasion by Activating ?-Catenin Signaling.
Klatskin Tumor
Alterations of the p53 tumor-suppressor gene and K-ras oncogene in perihilar cholangiocarcinomas from a high-incidence area.
Laryngeal Neoplasms
Expression of ras oncogene p21 protein in normal and neoplastic laryngeal tissues: correlation with histopathological features and epidermal growth factor receptors.
High level of galectin-1 expression is a negative prognostic predictor of recurrence in laryngeal squamous cell carcinomas.
Metabolic activation, DNA adducts, and H-ras mutations in human neoplastic and non-neoplastic laryngeal tissue.
Recombinant adenovirus encoding H-ras ribozyme induces apoptosis in laryngeal cancer cells through caspase- and mitochondria-dependent pathways.
[Express of human papillomavirus, P53 and H-ras gene in laryngeal cancer]
[Oncogenes and cancer of the larynx. EGFR, p21 ras and HPV-DNA infections]
Latent Infection
The guanine exchange factor SWAP70 mediates vGPCR-induced endothelial plasticity.
Latent Tuberculosis
Unbiased Identification of Blood-based Biomarkers for Pulmonary Tuberculosis by Modeling and Mining Molecular Interaction Networks.
Leiomyoma
Aspirin inhibits the proliferation of human uterine leiomyoma cells by downregulation of K?Ras?p110? interaction.
Expression of motility-related molecule Cdc42 in endometrial tissue in women with adenomyosis and ovarian endometriomata.
Identification of Differentially Expressed K-Ras Transcript Variants in Patients With Leiomyoma.
Leiomyosarcoma
A primary cardiac leiomyosarcoma with mutation at H-ras codon 12.
Detection of K-ras mutations in resected primary leiomyosarcoma.
Detection of transforming genes by transfection of DNA from primary soft-tissue tumours.
H-ras and K-ras gene mutations in primary human soft tissue sarcoma: concomitant mutations of the ras genes.
Leishmaniasis, Visceral
Leishmania major large RAB GTPase is highly immunogenic in individuals immune to cutaneous and visceral leishmaniasis.
Leukemia
7,12-DMBA-induced rat leukemia: a review with insights into future research.
A novel somatic K-Ras mutation in juvenile myelomonocytic leukemia.
Absence of Kirsten-ras oncogene activation in B-cell chronic lymphocytic leukemia.
Accuracy of DNA amplification from archival hematological slides for use in genetic biomarker studies.
Activation of Rac1 GTPase promotes leukemia cell chemotherapy resistance, quiescence and niche interaction.
Acute myeloid leukemia transforms the bone marrow niche into a leukemia-permissive microenvironment through exosome secretion.
Analysis of ras gene mutations and methylation state in human leukemias.
Cell Polarity and Division Symmetry Analyses in Transformed Blood Cells.
Combination of farnesyltransferase and Akt inhibitors is synergistic in breast cancer cells and causes significant breast tumor regression in ErbB2 transgenic mice.
Conditional immortalization and/or transformation of rat cells carrying v-abl or EJras oncogene in the presence or absence of glucocorticoid hormone.
Cytogenetic and molecular changes in leukemia found among atomic bomb survivors.
Dacarbazine-induced immunogenicity of a murine leukemia is attenuated in cells transfected with mutated K-ras gene.
Defective K-Ras oncoproteins overcome impaired effector activation to initiate leukemia in vivo.
Detection of high incidence of H-RAS oncogene point mutations in acute myelogenous leukemia.
Development of a multi-step leukemogenesis model of MLL-rearranged leukemia using humanized mice.
Effect of Clostridium difficile toxin B on IgE receptor-mediated signal transduction in rat basophilic leukemia cells: inhibition of phospholipase D activation.
Effector function for RAS oncogene in interleukin-3-dependent myeloid cells involves diminished efficacy of prostaglandin E1-mediated inhibition of proliferation.
Eicosapentaenoic acid activates RAS/ERK/C/EBP? pathway through H-Ras intron 1 CpG island demethylation in U937 leukemia cells.
Elf-2, a rhombotin-2 binding ets transcription factor: discovery and potential role in T cell leukemia.
Erythroleukemia cells acquire an alternative mitophagy capability.
Expression of a constitutively active mutant of M-Ras in normal bone marrow is sufficient for induction of a malignant mastocytosis/mast cell leukemia, distinct from the histiocytosis/monocytic leukemia induced by expression of activated H-Ras.
Expression of endogenous retrovirus-like sequences and cellular oncogenes during phenobarbital treatment and regeneration in rat liver.
Expression of the 6C3 antigen on murine hematopoietic neoplasms. Association with expression of abl, ras, fes, src, erbB, and Cas NS-1 oncogenes but not with myc.
Fc receptor-mediated phagocytosis requires CDC42 and Rac1.
Frequent rearrangements of retinoic acid receptor alpha gene and myl gene, and rare mutations of RAS and FMS genes in acute promyelocytic leukemia.
Friend leukemia virus integration 1 activates the Rho GTPase pathway and is associated with metastasis in breast cancer.
Genetics of myeloid leukemias.
Growth properties, differentiation capacity and oncogene expression in metastatic and nonmetastatic Friend leukemia cell variants.
High incidence of N and K-Ras activating mutations in multiple myeloma and primary plasma cell leukemia at diagnosis.
Inhibition of Rac GTPase signaling and downstream prosurvival Bcl-2 proteins as combination targeted therapy in MLL-AF9 leukemia.
Inhibitors of Ras signal transduction as antitumor agents.
Involvement of Rab27 in antigen-induced histamine release from rat basophilic leukemia 2H3 cells.
K-ras mutations and N-ras mutations in childhood acute leukemias with or without mixed-lineage leukemia gene rearrangements.
KRAS (G12D) Cooperates with AML1/ETO to Initiate a Mouse Model Mimicking Human Acute Myeloid Leukemia.
Lack of noncanonical RAS mutations in cytogenetically normal acute myeloid leukemia.
Leukemia-associated NOTCH1 alleles are weak tumor initiators but accelerate K-ras-initiated leukemia.
Leukemogenic risk of hydroxyurea therapy as a single agent in polycythemia vera and essential thrombocythemia: N- and K-ras mutations and microsatellite instability in chromosomes 5 and 7 in 69 patients.
Low frequency of ras oncogene mutations in Philadelphia-positive acute leukemia and report of a novel mutation H61 Leu in a single case.
MLL3 Induced by Luteolin Causes Apoptosis in Tamoxifen-Resistant Breast Cancer Cells through H3K4 Monomethylation and Suppression of the PI3K/AKT/mTOR Pathway.
Phospholipase C gamma negatively regulates Rac/Cdc42 activation in antigen-stimulated mast cells.
Rab5 and Rab11 maintain hematopoietic homeostasis by restricting multiple signaling pathways in Drosophila.
Rab7b, a novel lysosome-associated small GTPase, is involved in monocytic differentiation of human acute promyelocytic leukemia cells.
Rac and phosphatidylinositol 3-kinase regulate the protein kinase B in Fc epsilon RI signaling in RBL 2H3 mast cells.
Rac1 GTPase promotes interaction of hematopoietic stem/progenitor cell with niche and participates in leukemia initiation and maintenance in mouse.
ras and human tumors.
Ras and relatives--job sharing and networking keep an old family together.
Rearrangement and expression of T cell receptor and immunoglobulin loci in immortalized CD4-CD8- T cell lines.
Resveratrol induces FasL-related apoptosis through Cdc42 activation of ASK1/JNK-dependent signaling pathway in human leukemia HL-60 cells.
Rho GTPases in hematopoiesis and hemopathies.
Selective control of membrane ruffling and actin plaque assembly by the Rho GTPases Rac1 and CDC42 in FcepsilonRI-activated rat basophilic leukemia (RBL-2H3) cells.
Synthesis and biological activity of isoprenoid bisphosphonates.
The cell polarity determinant CDC42 controls division symmetry to block leukemia cell differentiation.
The hematopoietically expressed vav proto-oncogene shares homology with the dbl GDP-GTP exchange factor, the bcr gene and a yeast gene (CDC24) involved in cytoskeletal organization.
The role of ras gene mutation in gastric cancer and precancerous lesions.
The role of the oncogenic Rab35 in cancer invasion, metastasis, and immune evasion, especially in leukemia.
The TLR9 agonist (GNKG168) induces a unique immune activation pattern in vivo in children with minimal residual disease positive acute leukemia: Results of the TACL T2009-008 phase I study.
Transforming genes and chromosome aberrations in therapy-related leukemia and myelodysplastic syndrome.
Vitexin isolated from Prosopis cineraria leaves induce apoptosis in K-562 leukemia cells via inhibition of the BCR-ABL-Ras-Raf pathway.
[Application of flow cytometry to the study of hematologic disorders: analysis of oncogene products]
[Detection of ras gene mutation in various stages of gastric cancer by PCR/RFLP SSCP and DNA sequencing]
Leukemia, Erythroblastic, Acute
Defective RAB1B-related megakaryocytic ER-to-Golgi transport in RUNX1 haplodeficiency: impact on von Willebrand factor.
Leukemia, Lymphocytic, Chronic, B-Cell
A one-step DGGE scanning method for detection of mutations in the K-, N-, and H-ras oncogenes: mutations at codons 12, 13 and 61 are rare in B-cell non-Hodgkin's lymphoma.
Absence of Kirsten-ras oncogene activation in B-cell chronic lymphocytic leukemia.
Chronic lymphocytic leukemia cells induce defective LFA-1-directed T cell motility by altering Rho GTPase signaling that is reversible with lenalidomide.
The Phospholipase C-?2 Mutants R665W and L845F Identified in Ibrutinib-Resistant Chronic Lymphocytic Leukemia Patients are Hypersensitive to the Rho GTPase Rac2.
Trametinib and Dabrafenib in histiocytic sarcoma transdifferentiated from chronic lymphocytic leukemia with a K-RAS and a unique BRAF mutation.
[Flow cytometric analysis of oncogene products]
Leukemia, Lymphoid
N-ras gene point mutations in childhood acute lymphocytic leukemia correlate with a poor prognosis.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Activation of Harvey ras oncogene by mutation at codon 12 is very rare in hemopoietic malignancies.
Effect of Ras Inhibition in Hematopoiesis and BCR/ABL Leukemogenesis.
Induction of apoptosis by a dominant negative H-RAS mutant (116Y) in K562 cells.
Inhibition of small GTPase RalA regulates growth and arsenic-induced apoptosis in chronic myeloid leukemia (CML) cells.
p210(Bcr-Abl) desensitizes Cdc42 GTPase signaling for SDF-1alpha-directed migration in chronic myeloid leukemia cells.
Polymorphism T81C in H-RAS Oncogene Is Associated With Disease Progression in Imatinib (TKI) Treated Chronic Myeloid Leukemia Patients.
Ras oncogene mutations are rare late stage events in chronic myelogenous leukemia.
Small GTPase RAB45-mediated p38 activation in apoptosis of chronic myeloid leukemia progenitor cells.
Southern blot analysis of Bcr, N-ras, H-ras, c-myc and myb proto-oncogenes in blast crisis of chronic myelogenous leukemia.
Leukemia, Myeloid
Activation of Rac1 GTPase promotes leukemia cell chemotherapy resistance, quiescence and niche interaction.
Mutant H-ras over-expression inhibits a random apoptotic nuclease in myeloid leukemia cells.
Mutant RAS selectively promotes sensitivity of myeloid leukemia cells to apoptosis by a protein kinase C-dependent process.
Synergistic cytotoxic effects in myeloid leukemia cells upon cotreatment with farnesyltransferase and geranylgeranyl transferase-I inhibitors.
Leukemia, Myeloid, Acute
A case of therapy-related acute myeloid leukemia with inv(16)(p13.1q22) after single low-dose iodine-131 treatment for thyroid cancer.
Active oral regimen for elderly adults with newly diagnosed acute myelogenous leukemia: a preclinical and phase 1 trial of the farnesyltransferase inhibitor tipifarnib (R115777, Zarnestra) combined with etoposide.
ARHGEF3 controls HDACi-induced differentiation via RhoA-dependent pathways in acute myeloid leukemias.
Caspase-3 controls AML1-ETO-driven leukemogenesis via autophagy modulation in a ULK1 dependent manner.
Cell Polarity and Division Symmetry Analyses in Transformed Blood Cells.
Correlated flow cytometric analysis of H-ras p21 and DNA ploidy in acute myelogenous leukemia.
Detection of high incidence of H-RAS oncogene point mutations in acute myelogenous leukemia.
Detection of N-RAS and K-RAS in their active GTP-bound form in acute myeloid leukemia without activating RAS mutations.
Expression of normal and mutant ras proteins in human acute leukemia.
Features of Ras activation by a mislocalized oncogenic tyrosine kinase: FLT3 ITD signals via K-Ras at the plasma membrane of Acute Myeloid Leukemia cells.
MBD3/NuRD loss participates with KDM6A program to promote DOCK5/8 expression and Rac GTPase activation in human acute myeloid leukemia.
miR-34c-5p promotes eradication of acute myeloid leukemia stem cells by inducing senescence through selective RAB27B targeting to inhibit exosome shedding.
Multiple point mutation of N-ras and K-ras oncogenes in myelodysplastic syndrome and acute myelogenous leukemia.
Mutational analysis of K-ras codon 12 in blood samples of patients with acute myeloid leukemia.
Mutations in the ras proto-oncogenes in patients with myelodysplastic syndromes.
Nf1 deficiency co-operates with oncogenic K-RAS to induce acute myeloid leukemia in mice.
Oncogenic K-ras in mouse models of myeloproliferative disease and acute myeloid leukemia.
Pharmacological Rac1 inhibitors with selective apoptotic activity in human acute leukemic cell lines.
Prognostic importance of mutations in the ras proto-oncogenes in de novo acute myeloid leukemia.
Prognostic significance of N-RAS and K-RAS mutations in 232 patients with acute myeloid leukemia.
The cell polarity determinant CDC42 controls division symmetry to block leukemia cell differentiation.
The Prognostic Impact of K-RAS Mutations in Adult Acute Myeloid Leukemia Patients Treated with High Dose Cytarabine.
The prognostic impact of K-RAS mutations in adult acute myeloid leukemia patients treated with high-dose cytarabine.
Leukemia, Myelomonocytic, Juvenile
A novel somatic K-Ras mutation in juvenile myelomonocytic leukemia.
Leukemia, Plasma Cell
High incidence of N and K-Ras activating mutations in multiple myeloma and primary plasma cell leukemia at diagnosis.
Leukemia, Promyelocytic, Acute
Frequent rearrangements of retinoic acid receptor alpha gene and myl gene, and rare mutations of RAS and FMS genes in acute promyelocytic leukemia.
Rab7b, a novel lysosome-associated small GTPase, is involved in monocytic differentiation of human acute promyelocytic leukemia cells.
Leukemia, Radiation-Induced
Cytogenetic and molecular changes in leukemia found among atomic bomb survivors.
Mutation of RAS oncogene in atomic bomb radiation-exposed leukemia.
Leukemia, T-Cell
Elf-2, a rhombotin-2 binding ets transcription factor: discovery and potential role in T cell leukemia.
K-RasG12D-induced T-cell lymphoblastic lymphoma/leukemias harbor Notch1 mutations and are sensitive to gamma-secretase inhibitors.
Leukemia-Lymphoma, Adult T-Cell
Decoding pathogenesis factors involved in the progression of ATLL or HAM/TSP after infection by HTLV-1 through a systems virology study.
Leukoencephalopathies
Novel mutation in mitochondrial Elongation Factor EF-Tu associated to dysplastic leukoencephalopathy and defective mitochondrial DNA translation.
Leukopenia
Immunoproteomic to analysis the pathogenicity factors in leukopenia caused by Klebsiella pneumonia bacteremia.
Lewy Body Disease
Abnormal alpha-synuclein interactions with rab3a and rabphilin in diffuse Lewy body disease.
Lipoblastoma
Identification of a novel BOC-PLAG1 fusion gene in a case of lipoblastoma.
Identification of COL3A1 and RAB2A as novel translocation partner genes of PLAG1 in lipoblastoma.
Lipoma
Association of LPP and TAGAP Polymorphisms with Celiac Disease Risk: A Meta-Analysis.
Liposarcoma
Detection of transforming genes by transfection of DNA from primary soft-tissue tumours.
H-ras oncogene mutation in dedifferentiated liposarcoma. Polymerase chain reaction-restriction fragment length polymorphism analysis.
Liver Cirrhosis
HCC-derived exosomes elicit HCC progression and recurrence by epithelial-mesenchymal transition through MAPK/ERK signalling pathway.
Liver X receptors balance lipid stores in hepatic stellate cells via Rab18, a retinoid responsive lipid droplet protein.
Liver Cirrhosis, Experimental
H-ras oncogene expression and angiogenesis in experimental liver cirrhosis.
Liver Diseases
Integrated Analysis and Identification of Novel Biomarkers in Parkinson's Disease.
Pre-operative chemotherapy for colorectal cancer liver metastases: an update of recent clinical trials.
Liver Neoplasms
Absence of H-ras point mutation at codon 12 in N-methyl-N-nitrosourea-induced hepatocellular neoplasms in the rat.
Akt phosphorylation of deleted in liver cancer 1 abrogates its suppression of liver cancer tumorigenesis and metastasis.
Altered gene expression and genetic damage in North American fish populations.
Anti-tumor Properties of Picrasma quassioides Extracts in H-RasG12V Liver Cancer Are Mediated Through ROS-dependent Mitochondrial Dysfunction.
Deleted in liver cancer 1 (DLC1) negatively regulates Rho/ROCK/MLC pathway in hepatocellular carcinoma.
Design, Graph Theoretical Analysis and Insilico Modeling of Dunaliella bardawil Biomass Encapsulated N-Succinyl Chitosan Nanoparticles for Enhanced Anticancer Activity.
Detection of K-ras mutations in pancreatic and hepatic neoplasms by non-isotopic mismatched polymerase chain reaction.
DLC1 is a chromosome 8p tumor suppressor whose loss promotes hepatocellular carcinoma.
DLC1 suppresses NF-?B activity in prostate cancer cells due to its stabilizing effect on adherens junctions.
DLC2 modulates angiogenic responses in vascular endothelial cells by regulating cell attachment and migration.
Downregulation of serum RAB27B confers improved prognosis and is associated with hepatocellular carcinoma progression through PI3K-AKT-P21 signaling.
Expression profile of the tumor suppressor genes DLC-1 and DLC-2 in solid tumors.
Frequency of ras mutations in liver neoplasms from B6C3F1 mice exposed to tetrafluoroethylene for two years.
Hepatic and pulmonary carcinogenicity of methylene chloride in mice: a search for mechanisms.
Identification and characterization of Dlc1 isoforms in the mouse and study of the biological function of a single gene trapped isoform.
Identification of P-Rex1 in the Regulation of Liver Cancer Cell Proliferation and Migration via HGF/c-Met/Akt Pathway.
Identifying Cancer-Relevant Mutations in the DLC START Domain Using Evolutionary and Structure-Function Analyses.
Impact of Helicobacter hepaticus infection in B6C3F1 mice from twelve National Toxicology Program two-year carcinogenesis studies.
Mutations in ras genes in experimental tumours of rodents.
NTP Toxicology and Carcinogenesis Studies of Oxazepam (CAS No. 604-75-1) in Swiss-Webster and B6C3F1 Mice (Feed Studies).
Nuclear-targeted deleted in liver cancer 1 (DLC1) is less efficient in exerting its tumor suppressive activity both in vitro and in vivo.
Proto-Oncogene Serine/Threonine Kinase PIM3 Promotes Cell Migration via Modulating Rho GTPase Signaling.
Rab27B enhances drug resistance in hepatocellular carcinoma by promoting exosome-mediated drug efflux.
RAB9A Plays an Oncogenic Role in Human Liver Cancer Cells.
Regulation of white and brown adipocyte differentiation by RhoGAP DLC1.
Rho GTPase activating protein cDNA on chromosome 13q12 is the deleted in liver cancer (DLC2) gene.
Targeting ?-catenin in hepatocellular cancers induced by coexpression of mutant ?-catenin and K-Ras in mice.
Tensins are versatile regulators of Rho GTPase signalling and cell adhesion.
The effect of CXCL9 on the invasion ability of hepatocellular carcinoma through up-regulation of PREX2.
The role of Dlc1 isoform 2 in K-Ras2(G12D) induced thymic cancer.
[Effect of Cdc42 gene inhibited on proliferation, migration and invasion in human hepatocellular carcinoma cells].
Lung Diseases
A mutation in Rab38 small GTPase causes abnormal lung surfactant homeostasis and aberrant alveolar structure in mice.
Analysis and expression of Rab38 in oculocutaneous lung disease.
High frequency of K-ras mutations in normal appearing lung tissues and sputum of patients with lung cancer.
Targeting the mevalonate cascade as a new therapeutic approach in heart disease, cancer and pulmonary disease.
[Expressions of 8-OH-dG, k-ras, and p53 genes in pleural effusion cells and their clinical significances]
Lung Diseases, Interstitial
Expression and alteration of ras and p53 proteins in patients with lung carcinoma accompanied by idiopathic pulmonary fibrosis.
K-ras gene point mutation in neogenetic lesions of subpleural fibrotic lesions: either an early genetic event in lung cancer development or a non-specific genetic change during the inflammatory reparative process.
Lung Injury
Bmi1 is critical for lung tumorigenesis and bronchioalveolar stem cell expansion.
Critical role of the small GTPase RhoA in the development of pulmonary edema induced by Pseudomonas aeruginosa in mice.
Differential roles of STAT3 in the initiation and growth of lung cancer.
Endothelial Cdc42 deficiency impairs endothelial regeneration and vascular repair after inflammatory vascular injury.
Inactivation of Rab11a GTPase in Macrophages Facilitates Phagocytosis of Apoptotic Neutrophils.
Neuronal Wiskott-Aldrich syndrome protein regulates TGF-?1-mediated lung vascular permeability.
Oxidized phospholipids reduce ventilator-induced vascular leak and inflammation in vivo.
Small GTPase RAB6 deficiency promotes alveolar progenitor cell renewal and attenuates PM2.5-induced lung injury and fibrosis.
Lung Neoplasms
A central role for Foxp3+ regulatory T cells in K-Ras-driven lung tumorigenesis.
A cross-sectional study examining the expression of splice variants K-RAS4A and K-RAS4B in advanced non-small-cell lung cancer patients.
A detailed immunohistochemical analysis of the PI3K/AKT/mTOR pathway in lung cancer: correlation with PIK3CA, AKT1, K-RAS or PTEN mutational status and clinicopathological features.
A distinct mutational spectrum of p53 and K-ras genes in lung cancer of workers with silicosis.
A fast and convenient new technique to detect the therapeutic target, K-ras mutant, from peripheral blood in non-small cell lung cancer patients.
A genetic mouse model for metastatic lung cancer with gender differences in survival.
A novel combination of K-ras and myc amplification accompanied by point mutational activation of K-ras in a human lung cancer.
A novel point mutation at codon 146 of the K-ras gene in a human colorectal cancer identified by the polymerase chain reaction.
A personalized treatment for lung cancer: molecular pathways, targeted therapies, and genomic characterization.
A universal method for the mutational analysis of K-ras and p53 gene in non-small-cell lung cancer using formalin-fixed paraffin-embedded tissue.
Ablation of p120-catenin enhances invasion and metastasis of human lung cancer cells.
Abnormal expression of p120-catenin, E-cadherin, and small GTPases is significantly associated with malignant phenotype of human lung cancer.
Additional value of K-ras point mutations in bronchial wash fluids for diagnosis of peripheral lung tumours.
Adenoviral-Vector Based siRNA for Mutant K-ras as a Promising Tool for Lung Cancer Gene Therapy: A License to Kill.
Aerosol delivery of glucosylated polyethylenimine/phosphatase and tensin homologue deleted on chromosome 10 complex suppresses Akt downstream pathways in the lung of K-ras null mice.
Aerosol delivery of lentivirus-mediated O-glycosylation mutant osteopontin suppresses lung tumorigenesis in K-ras (LA1) mice.
Aerosol delivery of urocanic acid-modified chitosan/programmed cell death 4 complex regulated apoptosis, cell cycle, and angiogenesis in lungs of K-ras null mice.
Akt/protein kinase B is constitutively active in non-small cell lung cancer cells and promotes cellular survival and resistance to chemotherapy and radiation.
Akt1 deletion prevents lung tumorigenesis by mutant K-ras.
An important role for Myb-MuvB and its target gene KIF23 in a mouse model of lung adenocarcinoma.
An overview of farnesyltransferase inhibitors and their role in lung cancer therapy.
Analysis of K-RAS and P53 mutations in sputum samples.
Analysis of K-ras gene mutations in lung carcinomas: correlation with gender, histological subtypes, and clinical outcome.
Analysis of K-ras, p53, bcl-2 and Rb expression in non-small cell lung cancer cell lines.
Analysis of Mutations in K-ras and p53 Genes in Sputum and Plasma Samples.
Anti-tumorigenic effect of a K-ras ribozyme against human lung cancer cell line heterotransplants in nude mice.
ARVCF expression is significantly correlated with the malignant phenotype of non-small cell lung cancer.
Assessment of EGFR and K-ras mutations in fixed and fresh specimens from transesophageal ultrasound-guided fine needle aspiration in non-small cell lung cancer patients.
Assessment of epidermal growth factor receptor and K-ras mutation status in cytological stained smears of non-small cell lung cancer patients: correlation with clinical outcomes.
Assessment of somatic k-RAS mutations as a mechanism associated with resistance to EGFR-targeted agents: a systematic review and meta-analysis of studies in advanced non-small-cell lung cancer and metastatic colorectal cancer.
Association of epidermal growth factor receptor and K-Ras mutations with smoking history in non-small cell lung cancer patients.
Association of K-ras codon 12 transversions with short survival in non-small cell lung cancer.
Automated real-time PCR to determine K-ras codon 12 mutations in non-small cell lung cancer: comparison with immunohistochemistry and clinico-pathological features.
Avicin G is a potent sphingomyelinase inhibitor and blocks oncogenic K- and H-Ras signaling.
Biodistribution and Pharmacokinetics Study of siRNA-loaded Anti-NTSR1-mAb-functionalized Novel Hybrid Nanoparticles in a Metastatic Orthotopic Murine Lung Cancer Model.
Biomarkers for the lung cancer diagnosis and their advances in proteomics.
Biomarkers in non-small cell lung cancer prevention.
Broad overexpression of ribonucleotide reductase genes in mice specifically induces lung neoplasms.
c-Jun N-terminal kinase contributes to aberrant retinoid signaling in lung cancer cells by phosphorylating and inducing proteasomal degradation of retinoic acid receptor alpha.
C-Raf is required for the initiation of lung cancer by K-Ras.
Cell Division Cycle 42 plays a Cell type-Specific role in Lung Tumorigenesis.
Cellular protoonocogenes are infrequently amplified in untreated non-small cell lung cancer.
Changes in cancer cell metabolism revealed by direct sample analysis with MALDI mass spectrometry.
Chromosomal instability suppresses the growth of K-Ras-induced lung adenomas.
CHUK/IKK-? loss in lung epithelial cells enhances NSCLC growth associated with HIF up-regulation.
Clinical outcome of patients with non-small cell lung cancer receiving front-line chemotherapy according to EGFR and K-RAS mutation status.
Clinical significance and the correlation of expression between Let-7 and K-ras in non-small cell lung cancer.
Clonal origin of multiple lung cancers: K-ras and p53 mutations determined by nonradioisotopic single-strand conformation polymorphism analysis.
Co-dependency of PKC? and K-Ras: inverse association with cytotoxic drug sensitivity in KRAS mutant lung cancer.
Combination Therapy of NSCLC Using Hsp90 Inhibitor and Doxorubicin Carrying Functional Nanoceria.
Combination therapy targeting BCL6 and phospho-STAT3 defeats intra-tumor heterogeneity in a subset of non-small cell lung cancers.
Comment on "Methylation patterns and K-ras mutations in tumor and paired serum of resected non-small-call lung cancer patients" (Cancer Letters 2003;193:207-216).
Comparative Screening of K-ras Mutations in Colorectal Cancer and Lung Cancer Patients Using a Novel Real-Time PCR with ADx-K-ras Kit and Sanger DNA Sequencing.
Comparison of EGFR and K-RAS gene status between primary tumours and corresponding metastases in NSCLC.
Comparison of K-ras gene mutations in tumour and sputum DNA of patients with lung cancer.
Comparison of oncogene mutation detection and telomerase activity for the molecular staging of non-small cell lung cancer.
Conditional mouse lung cancer models using adenoviral or lentiviral delivery of Cre recombinase.
Converged Rab37/IL-6 trafficking and STAT3/PD-1 transcription axes elicit an immunosuppressive lung tumor microenvironment.
COPD-Type lung inflammation promotes K-ras mutant lung cancer through epithelial HIF-1? mediated tumor angiogenesis and proliferation.
CpG island promoter hypermethylation of the Ras-effector gene NORE1A occurs in the context of a wild-type K-ras in lung cancer.
CT Radiogenomic Characterization of EGFR, K-RAS, and ALK Mutations in Non-Small Cell Lung Cancer.
Curcumin Inhibits COPD-Like Airway Inflammation and Lung Cancer Progression in Mice.
Cyclophilin D counteracts P53-mediated growth arrest and promotes Ras tumorigenesis.
Cytoplasmic P120ctn Promotes Gefitinib Resistance in Lung Cancer Cells by Activating PAK1 and ERK Pathway.
DA-Raf, a dominant-negative antagonist of the Ras-ERK pathway, is a putative tumor suppressor.
Deficiency of a potential 3p21.3 tumor suppressor gene UBE1L (UBA7) does not accelerate lung cancer development in K-ras(LA2) mice.
Deletion of cyclooxygenase-2 inhibits K-ras-induced lung carcinogenesis.
DEPENDENCE ON THE MUC1-C ONCOPROTEIN IN NON-SMALL CELL LUNG CANCER CELLS WITH EGFR AND K-RAS MUTATIONS.
Deregulation of DUSP activity in EGFR-mutant lung cancer cell lines contributes to sustained ERK1/2 signaling.
Design, synthesis, and biological evaluation of novel substituted thiourea derivatives as potential anticancer agents for NSCLC by blocking K-Ras protein-effectors interactions.
Detection and characterization of oncogene mutations in preneoplastic and early neoplastic lesions.
Detection and Characterization of Oncogene Mutations in Preneoplastic and Early Neoplastic Lesions.
Detection by denaturant gradient gel electrophoresis of tumor-specific mutations in biopsies and relative bronchoalveolar lavage fluid from resectable non-small cell lung cancer.
Detection of activated K-ras in non-small cell lung cancer by membrane array: a comparison with direct sequencing.
Detection of activating mutations in the ras family genes in cytological specimens from lung-tumors.
Detection of codon 61 point mutations of the K-ras gene in lung and colorectal cancers by enriched PCR.
Detection of human papilloma virus (HPV) and K-ras mutations in human lung carcinomas.
Detection of infrequent and multiple K-ras mutations in human tumors and tumor-adjacent tissues.
Detection of K-ras and p53 mutations in bronchoscopically obtained malignant and non-malignant tissue from patients with non-small cell lung cancer.
Detection of K-ras and p53 mutations in sputum samples of lung cancer patients using laser capture microdissection microscope and mutation analysis.
Detection of K-ras gene mutations in non-neoplastic lung tissue and lung cancers.
Detection of K-ras mutation in sputum by mutant-allele-specific amplification (MASA).
Detection of K-ras mutations in lung carcinomas: relationship to prognosis.
Detection of k-ras mutations in nonsmall cell lung-carcinoma.
Detection of K-Ras mutations in tumour samples of patients with non-small cell lung cancer using PNA-mediated PCR clamping.
Detection of K-ras mutations of bronchoalveolar lavage fluid cells aids the diagnosis of lung cancer in small pulmonary lesions.
Detection of K-ras oncogene mutations by polymerase chain reaction-based ligase chain reaction.
Detection of K-ras oncogene mutations in bronchoalveolar lavage fluid for lung cancer diagnosis.
Detection of k-ras point mutations in codons 12 and 13 in non-small cell lung cancers.
Detection of K-ras point mutations in sputum from patients with adenocarcinoma of the lung by point-EXACCT.
Detection of low-fraction K-ras mutations in primary lung tumors using a sensitive method.
Detection of miR-155-5p and imaging lung cancer for early diagnosis: in vitro and in vivo study.
Detection of p53 and K-ras mutations in sputum of individuals exposed to smoky coal emissions in Xuan Wei County, China.
Detection of Point Mutations of K-ras Oncogene and p53 Tumor-Suppressor Gene in Sputum Samples.
Detection of serum factors enhancing cell mutability from lung cancer patients by application of hypermutable human RS cells.
Development of a rapid and practical mutation screening assay for human lung adenocarcinoma.
Diacylglycerol kinase ? modulates oncogenic properties of lung cancer cells.
Different site mutation of the K-ras gene in a patient with metachronous double lung cancers.
Different types of K-Ras mutations could affect drug sensitivity and tumour behaviour in non-small-cell lung cancer.
Differential frequencies of p16(INK4a) promoter hypermethylation, p53 mutation, and K-ras mutation in exfoliative material mark the development of lung cancer in symptomatic chronic smokers.
Differential response to 1?,25-dihydroxyvitamin D(3) (1?,25(OH)(2)D(3)) in non-small cell lung cancer cells with distinct oncogene mutations.
Distinctive evaluation of nonmucinous and mucinous subtypes of bronchioloalveolar carcinomas in EGFR and K-ras gene-mutation analyses for Japanese lung adenocarcinomas: confirmation of the correlations with histologic subtypes and gene mutations.
Distribution of p53 and K-ras mutations in human lung cancer tissues.
DNA methylation of the CYP1A1 enhancer is associated with smoking-induced genetic alterations in human lung.
Downregulation of miR-25 modulates non-small cell lung cancer cells by targeting CDC42.
Downregulation of RECK by promoter methylation correlates with lymph node metastasis in non-small cell lung cancer.
Dr. Neri et al.: Prognostic role of K-ras mutations in non-small cell lung cancer: Still an issue for open debate.
Dual phosphoinositide 3-kinase/mammalian target of rapamycin blockade is an effective radiosensitizing strategy for the treatment of non-small cell lung cancer harboring K-RAS mutations.
Dual targeting of PI3K and MEK enhances the radiation response of K-RAS mutated non-small cell lung cancer.
Early recognition of lung cancer by integrin targeted imaging in K-ras mouse model.
Effect of promoter and intron 2 polymorphisms on murine lung K-ras gene expression.
Effects of silencing Rab27a gene on biological characteristics and chemosensitivity of non-small cell lung cancer.
Efficacy of PHA-848125, a cyclin-dependent kinase inhibitor, on the K-Ras(G12D)LA2 lung adenocarcinoma transgenic mouse model: evaluation by multimodality imaging.
EGF-stimulated activation of Rab35 regulates RUSC2-GIT2 complex formation to stabilize GIT2 during directional lung cancer cell migration.
EGFR and K-ras mutation analysis in non-small cell lung cancer: comparison of paraffin embedded versus frozen specimens.
EGFR and K-RAS mutations and ERCC1, TUBB3, TYMS, RRM1 and EGFR mRNA expression in non-small cell lung cancer: Correlation with clinical response to gefitinib or chemotherapy.
EGFR autophosphorylation but not protein score correlates with histologic and molecular subtypes in lung adenocarcinoma.
Enhanced MET Translation and Signaling Sustains K-Ras-Driven Proliferation under Anchorage-Independent Growth Conditions.
Enhancement of lung carcinogenesis initiated with 4-(N-hydroxymethylnitrosamino)-1-(3-pyridyl)-1-butanone by Ogg1 gene deficiency in female, but not male, mice.
Enhancing therapeutic efficacy of the MEK inhibitor, MEK162, by blocking autophagy or inhibiting PI3K/Akt signaling in human lung cancer cells.
Enterolactone alters FAK-Src signaling and suppresses migration and invasion of lung cancer cell lines.
Epidermal growth factor receptor and K-Ras mutations and resistance of lung cancer to insulin-like growth factor 1 receptor tyrosine kinase inhibitors.
Epidermal growth factor receptor and K-RAS status in two cohorts of squamous cell carcinomas.
Epidermal Growth Factor Receptor Signaling in Nonsmall Cell Lung Cancer.
Epigenetic regulation of TGF-?-induced EMT by JMJD3/KDM6B histone H3K27 demethylase.
Epithelial cell migration as a potential therapeutic target in early lung cancer.
ERK2-dependent reactivation of Akt mediates the limited response of tumor cells with constitutive K-RAS activity to PI3K inhibition.
Erratum and apology re: "Detection of K-ras oncogene mutations in bronchoalveolar lavage fluid for lung cancer diagnosis".
Exosomal expression of RAB27A and its related lncRNA Lnc-RNA-RP11-510M2 in lung cancer.
Exosomes derived from Rab27a?overexpressing tumor cells elicit efficient induction of antitumor immunity.
Expression analysis of Cdc42 in lung cancer and modulation of its expression by curcumin in lung cancer cell lines.
Expression of hedgehog signaling molecules in lung cancer.
Expression of the receptor tyrosine kinase EphA2 is increased in smokers and predicts poor survival in non-small cell lung cancer.
Expression profile-defined classification of lung adenocarcinoma shows close relationship with underlying major genetic changes and clinicopathologic behaviors.
Facilitated detection of oncogene mutations from exfoliated tissue material by a PNA-mediated 'enriched PCR' protocol.
FHIT and p53 gene abnormalities in bronchioloalveolar carcinomas. Correlations with clinicopathological data and K-ras mutations.
Fingolimod augments Pemetrexed killing of non-small cell lung cancer and overcomes resistance to ERBB inhibition.
Fluorescence background subtraction technique for hybrid fluorescence molecular tomography/x-ray computed tomography imaging of a mouse model of early stage lung cancer.
Foxm1 transcription factor is required for the initiation of lung tumorigenesis by oncogenic Kras(G12D.)
Frequent detection of ras and p53 mutations in brush cytology samples from lung cancer patients by a restriction fragment length polymorphism-based "enriched PCR" technique.
Frequent down-regulation of hRAB37 in metastatic tumor by genetic and epigenetic mechanisms in lung cancer.
Geminin functions downstream of p53 in K-ras-induced gene amplification of dihydrofolate reductase.
Gender is a risk factor for lung cancer.
Gene analysis of K-, H-ras, p53, and retinoblastoma susceptibility genes in human lung cancer cell lines by the polymerase chain reaction/single-strand conformation polymorphism method.
Generation of a ribozyme-adenoviral vector against K-ras mutant human lung cancer cells.
Genetic alterations in K-ras and p53 cancer genes in lung neoplasms from B6C3F1 mice exposed to cumene.
Genetic alterations in K-ras and p53 cancer genes in lung neoplasms from Swiss (CD-1) male mice exposed transplacentally to AZT.
Genetic analysis of the catalytic domain of the GAP gene in human lung cancer cell lines.
Genetic evidence for an independent origin of multiple preneoplastic and neoplastic lung lesions.
Genetic factors in lung disease. Part II: Lung cancer and angiotensin converting enzyme gene.
Genome and transcriptome sequencing of lung cancers reveal diverse mutational and splicing events.
Genomics of non-small cell lung cancer (NSCLC): Association between CT-based imaging features and EGFR and K-RAS mutations in 122 patients-An external validation.
Glucose-6-Phosphate Dehydrogenase Is Not Essential for K-Ras-Driven Tumor Growth or Metastasis.
Group IIa secretory phospholipase expression correlates with group IIa secretory phospholipase inhibition-mediated cell death in K-ras mutant lung cancer cells.
Growth inhibitory effect of anti-K-ras adenovirus on lung cancer cells.
Growth regulation via insulin-like growth factor binding protein-4 and -2 in association with mutant K-ras in lung epithelia.
GSTM1, P53 and K-ras molecular detection in resectable non-small cell lung cancer by denaturing gradient gel electrophoresis-bronchoalveolar lavage fluid analysis.
Guanine Nucleotide Exchange Factors for RhoGTPases: Good Therapeutic Targets for Cancer Therapy?
Hepatic and pulmonary carcinogenicity of methylene chloride in mice: a search for mechanisms.
High frequency of codon 61 K-ras A-->T transversions in lung and Harderian gland neoplasms of B6C3F1 mice exposed to chloroprene (2-chloro-1,3-butadiene) for 2 years, and comparisons with the structurally related chemicals isoprene and 1,3-butadiene.
High frequency of K-ras codon 12 mutations in bronchoalveolar lavage fluid of patients at high risk for second primary lung cancer.
High frequency of K-ras mutations in normal appearing lung tissues and sputum of patients with lung cancer.
High TUBB3 expression, an independent prognostic marker in patients with early non small cell lung cancer (NSCLC) treated by preoperative chemotherapy, is regulated by K-Ras signaling pathway.
Histochemical characterization of non-neuroendocrine tumors and neuroendocrine cell hyperplasia induced in hamster lung by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone with or without hyperoxia.
Hyperglycemia promotes K-Ras-induced lung tumorigenesis through BASCs amplification.
Hypomethylation of CCGG sites in the 3' region of H-ras protooncogene is frequent and is associated with H-ras allele loss in non-small cell lung cancer.
Identification and imaging of miR-155 in the early screening of lung cancer by targeted delivery of octreotide-conjugated chitosan-molecular beacon nanoparticles.
Identification of a new inhibitor of KRAS-PDE? interaction targeting KRAS mutant non-small cell lung cancer.
Identification of a novel subpopulation of Caspase-4 positive non-small cell lung Cancer patients.
Identification of a small molecule with synthetic lethality for K-ras and protein kinase C iota.
Identification of secreted proteins that mediate cell-cell interactions in an in vitro model of the lung cancer microenvironment.
IL6 Blockade Reprograms the Lung Tumor Microenvironment to Limit the Development and Progression of K-ras-Mutant Lung Cancer.
Imaging primary lung cancers in mice to study radiation biology.
Immunogenicity of Del19 EGFR mutations in Chinese patients affected by lung adenocarcinoma.
Immunohistochemical evaluation of P21ras and P53 proteins expression in human non-small-cell lung cancers.
Impact of smoking on frequency and spectrum of K-RAS and EGFR mutations in treatment naive Indonesian lung cancer patients.
Implications and prognostic value of K-ras mutation for early-stage lung cancer in women.
In Silico Screening of Mutated K-Ras Inhibitors from Malaysian Typhonium flagelliforme for Non-Small Cell Lung Cancer.
In vitro anti-tumor immune response induced by dendritic cells transfected with recombinant adenovirus carrying mutant K-ras genes.
In vitro study of farnesyltransferase inhibitor SCH 66336, in combination with chemotherapy and radiation, in non-small cell lung cancer cell lines.
Incidence and possible clinical significance of K-ras oncogene activation in adenocarcinoma of the human lung.
Increased epidermal growth factor receptor (EGFR) gene copy number is strongly associated with EGFR mutations and adenocarcinoma in non-small cell lung cancers: a chromogenic in situ hybridization study of 182 patients.
Increased frequency of K-ras mutations in lung neoplasms from female B6C3F1 mice exposed to ozone for 24 or 30 months.
Increased prevalence of K-ras oncogene mutations in lung adenocarcinoma.
Inhibition effects of Yuxiao San combined with cisplatin on transplanted tumor growths via upregulation of nm-23 and downregulation of K-ras in Lewis lung cancer mice.
Inhibition of AKT1 signaling promotes invasion and metastasis of non-small cell lung cancer cells with K-RAS or EGFR mutations.
Inhibition of CDC42 reduces macrophage recruitment and suppresses lung tumorigenesis in vivo.
Inhibition of K-Ras4B-plasma membrane association with a membrane microdomain-targeting peptide.
Inhibition of lung cancer growth: ATP citrate lyase knockdown and statin treatment leads to dual blockade of mitogen-actiated protein kinase (MAPK) and phosphatidylinositol-3- kinase (PI3K)/AKT pathways.
Inhibition of oncogenic K-ras signaling by aerosolized gene delivery in a mouse model of human lung cancer.
Inhibitors Targeting CDK9 Show High Efficacy against Osimertinib and AMG510 Resistant Lung Adenocarcinoma Cells.
Interaction between smoking and asbestos in human lung adenocarcinoma: role of K-ras mutations.
Interaction between the bone morphogenetic proteins and Ras/MAP-kinase signalling pathways in lung cancer.
Interferon-? reduces the gefitinib sensitivity of human non-small cell lung cancer.
Interleukin-6 Prevents the Initiation but Enhances the Progression of Lung Cancer.
Interplay between estrogen and Stat3/NF-?B-driven immunomodulation in lung cancer.
Interplay between menin and K-Ras in regulating lung adenocarcinoma.
Is there a prognostic role of K-ras point mutations in the serum of patients with advanced non-small cell lung cancer?
Isolation of a chemical inhibitor against K-Ras-induced p53 suppression through natural compound screening.
JMJD2A promotes cellular transformation by blocking cellular senescence through transcriptional repression of the tumor suppressor CHD5.
K-ras activation generates an inflammatory response in lung tumors.
K-ras activation in non-small cell lung cancer in the dog.
K-ras and p53 mutations are an independent unfavourable prognostic indicator in patients with non-small-cell lung cancer.
K-ras as a target for lung cancer therapy.
K-ras codon 12 mutations detected with enriched PCR method in operable non-small cell lung cancer.
K-ras codon 12 mutations may be detected in serum of patients suffering from adeno- and large cell lung carcinoma. A preliminary report.
K-ras gene mutation in sputum samples containing atypical cells and adenocarcinoma cells in the lung.
K-ras gene mutation is a useful predictor of the survival of early stage colorectal cancers.
K-ras gene mutations in non-small cell lung cancer in Japanese.
K-ras gene point mutation in neogenetic lesions of subpleural fibrotic lesions: either an early genetic event in lung cancer development or a non-specific genetic change during the inflammatory reparative process.
K-ras gene point mutation: a stable tumor marker in non-small cell lung carcinoma.
K-ras genotypes and prognosis in non-small-cell lung cancer.
k-RAS mutation and resistance to epidermal growth factor receptor-tyrosine kinase inhibitor treatment in patients with nonsmall cell lung cancer.
K-ras mutation in sputum of patients with or without lung cancer.
K-ras mutation in sputum of primary lung cancer patients does not always reflect that of cancerous cells.
K-ras mutation promotes ionizing radiation-induced invasion and migration of lung cancer in part via the Cathepsin L/CUX1 pathway.
K-ras mutation: early detection in molecular diagnosis and risk assessment of colorectal, pancreas, and lung cancers--a review.
K-ras mutations are a relatively late event in the pathogenesis of lung carcinomas.
K-ras mutations in 239PuO2 canine lung neoplasms.
K-ras mutations in circulating DNA from pancreatic and lung cancers: bridging methodology for a common validation of the molecular diagnosis value.
K-ras mutations in human adenocarcinoma of the lung: association with smoking and occupational exposure to asbestos.
K-ras mutations in lung cancer: the "mysterious mutation".
K-ras mutations in lung carcinomas from nonsmoking women exposed to unvented coal smoke in China.
K-ras mutations in lung tumors and tumors from other organs are consistent with a common mechanism of ethylene oxide tumorigenesis in the B6C3F1 mouse.
k-RAS mutations in non-small cell lung cancer patients treated with TKIs among smokers and non-smokers: a meta-analysis.
K-Ras Mutations in Non-Small-Cell Lung Cancer: Prognostic and Predictive Value.
K-ras mutations in non-small-cell lung carcinoma: a review.
K-ras oncogene activation in atypical alveolar hyperplasias of the human lung.
K-ras oncogene mutation as a prognostic marker in non-small cell lung cancer: a combined analysis of 881 cases.
K-ras point mutation detection in lung cancer: comparison of two approaches to somatic mutation detection using ARMS allele-specific amplification.
K-ras point mutation occurs in the early stage of carcinogenesis in lung cancer.
K-Ras promotes the non-small lung cancer cells survival by cooperating with sirtuin 1 and p27 under ROS stimulation.
K-ras proto-oncogene exhibits tumor suppressor activity as its absence promotes tumorigenesis in murine teratomas.
K-ras role in lung cancer therapy.
K-Ras-Activated Cells Can Develop into Lung Tumors When Runx3-Mediated Tumor Suppressor Pathways Are Abrogated.
Knockdown of mutant K-ras expression by adenovirus-mediated siRNA inhibits the in vitro and in vivo growth of lung cancer cells.
Knockdown of the sodium-dependent phosphate co-transporter 2b (NPT2b) suppresses lung tumorigenesis.
Kos1, a nonreceptor tyrosine kinase that suppresses Ras signaling.
Kruppel-like factor 5 is not required for K-RasG12D lung tumorigenesis, but represses ABCG2 expression and is associated with better disease-specific survival.
Lack of prognostic significance of p53 and K-ras mutations in primary resected non-small-cell lung cancer on E4592: a Laboratory Ancillary Study on an Eastern Cooperative Oncology Group Prospective Randomized Trial of Postoperative Adjuvant Therapy.
LATS2 tumour specific mutations and down-regulation of the gene in non-small cell carcinoma.
Lentivirus-mediated carboxyl-terminal modulator protein gene transfection via aerosol in lungs of K-ras null mice.
Life-span inhalation exposure to mainstream cigarette smoke induces lung cancer in B6C3F1 mice through genetic and epigenetic pathways.
LncRNA PCAT-1 upregulates RAP1A through modulating miR-324-5p and promotes survival in lung cancer.
Long noncoding RNA RHPN1-AS1 promotes colorectal cancer progression via targeting miR-7-5p/OGT axis.
Long-term toxicity studies of ozone in F344/N rats and B6C3F1 mice.
Loss of RASSF2 Enhances Tumorigencity of Lung Cancer Cells and Confers Resistance to Chemotherapy.
Loss of the novel tumour suppressor and polarity gene Trim62 (Dear1) synergizes with oncogenic Ras in invasive lung cancer.
Lovastatin overcomes gefitinib resistance in human non-small cell lung cancer cells with K-Ras mutations.
Low frequency of alterations in p53, K-ras, and mdm2 in rat lung neoplasms induced by diesel exhaust or carbon black.
Low frequency of p53 and k-ras codon 12 mutations in non-small cell lung carcinoma (NSCLC) tumors and surgical margins.
Low mutational rate of K-ras codon 12 in singular bronchoscopy specimens in suspected lung cancer.
Lung cancer and past occupational exposure to asbestos. Role of p53 and K-ras mutations.
Lung cancer in US women: a contemporary epidemic.
Lung cancer-associated SNP at the beginning of mouse k-ras gene intron 2 is essential for transcription factor binding.
Lung tumorigenesis associated with erb-B-2 and erb-B-3 overexpression in human erb-B-3 transgenic mice is enhanced by methylnitrosourea.
Luteolin attenuates migration and invasion of lung cancer cells via suppressing focal adhesion kinase and non-receptor tyrosine kinase signaling pathway.
MALT1 is required for EGFR-induced NF-?B activation and contributes to EGFR-driven lung cancer progression.
Map kinase activation correlates with K-ras mutation and loss of heterozygosity on chromosome 6 in alveolar bronchiolar carcinomas from B6C3F1 mice exposed to vanadium pentoxide for 2 years.
Melphalan inhibits adenoma development through modulating the expression of K-ras-specific markers in K-ras Tg mice.
Methylation patterns and K-ras mutations in tumor and paired serum of resected non-small-cell lung cancer patients.
MicroRNA let-7a Inhibits the Proliferation and Invasion of Nonsmall Cell Lung Cancer Cell Line 95D by Regulating K-Ras and HMGA2 Gene Expression.
microRNA-148a-3p inhibited the proliferation and epithelial-mesenchymal transition progression of non-small-cell lung cancer via modulating Ras/MAPK/Erk signaling.
microRNA-195 Promotes Small Cell Lung Cancer Cell Apoptosis via Inhibiting Rap2C Protein-Dependent MAPK Signal Transduction.
MicroRNA-29a functions as a potential tumor suppressor through directly targeting CDC42 in non-small cell lung cancer.
MicroRNA-30b/c inhibits non-small cell lung cancer cell proliferation by targeting Rab18.
miR-124 Inhibits Lung Tumorigenesis Induced by K-ras Mutation and NNK.
MiR-135a inhibits non-small cell lung cancer progression by suppressing RAB1B expression and the RAS pathway.
miR-137 inhibits the proliferation of lung cancer cells by targeting Cdc42 and Cdk6.
MiR-185-5p targets RAB35 gene to regulate tumor cell-derived exosomes-mediated proliferation, migration and invasion of non-small cell lung cancer cells.
miR-337-3p and its targets STAT3 and RAP1A modulate taxane sensitivity in non-small cell lung cancers.
MiR-501-3p functions as a tumor suppressor in non-small cell lung cancer by downregulating RAP1A.
MiroRNA-188 Acts as Tumor Suppressor in Non-Small-Cell Lung Cancer by Targeting MAP3K3.
Mitochondrial catalase suppresses naturally occurring lung cancer in old mice.
Modification of mutant K-ras gene expression in non-small cell lung cancer (NSCLC).
Molecular alterations in spontaneous sputum of cancer-free heavy smokers: results from a large screening program.
Molecular analysis of p53 and K-ras in lung carcinomas of coal miners.
Molecular assessment of lymph nodes in patients with resected stage I non-small cell lung cancer: preliminary results of a prospective study.
Molecular epidemiology of pancreatic cancer.
Molecular footprints of human lung cancer progression.
Molecular genetic tumor markers in the early diagnosis and screening of non-small-cell lung cancer.
Molecular genetics of small cell lung carcinoma.
Molecular margin analysis predicts local recurrence after sublobar resection of lung cancer.
Molecular staging of non-small cell lung cancer according to K-ras genotypes.
Mouse model for lung tumorigenesis through Cre/lox controlled sporadic activation of the K-Ras oncogene.
Mouse model for probing tumor suppressor activity of protein phosphatase 2A in diverse signaling pathways.
Mucoepidermoid carcinoma of the lung, response to EGFR inhibitors, EGFR and K-RAS mutations, and differential diagnosis.
Multiple MicroRNAs synergistically promote tolerance to epidermal growth factor receptor-targeted drugs in smoked lung cancer therapies.
Mutant K-ras oncogenes in colon cancers Do not predict Patient's chemotherapy response or survival
Mutated K-ras gene analysis in a randomized trial of preoperative chemotherapy plus surgery versus surgery in stage IIIA non-small cell lung cancer.
Mutation and polymorphism in the EGFR-TK domain associated with lung cancer.
Mutational activation of the K-ras oncogene and the effect of chemotherapy in advanced adenocarcinoma of the lung: a prospective study.
Mutational activation of the K-ras oncogene. A possible pathogenetic factor in adenocarcinoma of the lung.
Mutations in epidermal growth factor receptor and K-ras in Chinese patients with colorectal cancer.
Mutations in K-ras codon 12 detected in plasma DNA are not an indicator of disease in patients with non-small cell lung cancer.
Mutations in ras genes in experimental tumours of rodents.
Mutations of p53 and K-ras genes as prognostic factors for non-small cell lung cancer.
Mutations of ras genes distinguish a subset of non-small-cell lung cancer cell lines from small-cell lung cancer cell lines.
Mutations of ras protooncogenes and p53 tumor suppressor gene in cardiac hemangiosarcomas from B6C3F1 mice exposed to 1,3-butadiene for 2 years.
Nanomedicine-Assisted Combination Therapy of NSCLC: New Platinum-Based Anticancer Drug Synergizes the Therapeutic Efficacy of Ganetespib.
New molecular approaches to lung cancer: biological and clinical implications of P53, P16 and K-RAS studies.
NF-kappaB in lung tumorigenesis.
No association between the XPD 312, 751, or XRCC1 399 polymorphisms and K-ras gene mutation in smoking non-small-cell lung cancer.
No occurrence of DNA-polymerase Beta-gene mutation in human lung-carcinoma cell-lines with k-ras as, p53, or rb gene alterations.
Novel involvement of RhebL1 in sphingosylphosphorylcholine-induced keratin phosphorylation and reorganization: Binding to and activation of AKT1.
NTP Toxicology and Carcinogenesis Studies of Tetranitromethane (CAS No. 509-14-8) in F344/N Rats and B6C3F1 Mice (Inhalation Studies).
Nullifying the CDKN2A/B Locus Promotes Mutant K-ras Lung Tumorigenesis.
Occurrence of ras mutations in human lung cancer. Minireview.
Oncogenes and Tumor Suppressor Genes in the Carcinogenicity of Fibers and Particles.
Oncogenic Activity of Ect2 Is Regulated through Protein Kinase C{iota}-mediated Phosphorylation.
Oncogenic K-ras confers SAHA resistance by up-regulating HDAC6 and c-myc expression.
Oncogenic K-Ras regulates proliferation and cell junctions in lung epithelial cells through induction of cyclooxygenase-2 and activation of metalloproteinase-9.
Oncogenic KRAS signaling and YAP1/?-catenin: Similar cell cycle control in tumor initiation.
Optimization of patient selection for gefitinib in non-small cell lung cancer by combined analysis of epidermal growth factor receptor mutation, K-ras mutation, and Akt phosphorylation.
Origin and pharmacological modulation of tumor-associated regulatory dendritic cells.
Overexpression of Bcl-2 and mutations in p53 and K-ras in resected human non-small cell lung cancers.
Overexpression of small GTPases directly correlates with expression of ?-catenin and their coexpression predicts a poor clinical outcome in nonsmall cell lung cancer.
Overview of genetic and molecular events in the pathogenesis of lung cancer.
p120-catenin is transcriptionally downregulated by FOXC2 in non-small cell lung cancer cells.
p38? negatively regulates survival and malignant selection of transformed bronchioalveolar stem cells.
p53 Activation by Blocking Snail : A Novel Pharmacological Strategy for Cancer.
p53 and K-ras in radon-associated lung adenocarcinoma.
p53 and K-ras mutations in lung cancers from former and never-smoking women.
p53 and K-ras mutations in lung tissues and sputum samples of individuals exposed to smoky coal emissions in Xuan Wei County, China.
Partial suppression of tumorigenicity in a human lung cancer cell line transfected with Krev-1.
Pathologic and molecular features of screening low-dose computed tomography (LDCT)-detected lung cancer: a baseline and 2-year repeat study.
PCGF3 promotes the proliferation and migration of non-small cell lung cancer cells via the PI3K/AKT signaling pathway.
Personalized medicine and treatment approaches in non-small-cell lung carcinoma.
Phenotype of bone metastases of non-small cell lung cancer: epidermal growth factor receptor expression and K-RAS mutational status.
Phosphorylation of Rab37 by protein kinase C alpha inhibits the exocytosis function and metastasis suppression activity of Rab37.
PKC? regulates integrin ?V?3 expression and transformed growth of K-ras dependent lung cancer cells.
Point mutations of K-ras and H-ras genes in forestomach neoplasms from control B6C3F1 mice and following exposure to 1,3-butadiene, isoprene or chloroprene for up to 2-years.
Polyisoprenylated cysteinyl amide inhibitors deplete K-Ras and induce caspase-dependent apoptosis in lung cancer cells.
Predictive and Prognostic Biomarkers for Patients Treated with Anti-EGFR Agents in Lung Cancer: A Systemic Review and Meta-Analysis.
Predictive and prognostic biomarkers with therapeutic targets in breast, colorectal, and non-small cell lung cancers: A systemic review of current development, evidence, and recommendation.
Predictive value of K-ras and PIK3CA in non-small cell lung cancer patients treated with EGFR-TKIs: a systemic review and meta-analysis.
Predominant K-ras codon 12 G --> A transition in chemically induced lung neoplasms in B6C3F1 mice.
Prevention of orthotopic human lung cancer growth by intratracheal instillation of a retroviral antisense K-ras construct.
PRL-1 tyrosine phosphatase regulates c-Src levels, adherence, and invasion in human lung cancer cells.
Prognostic and predictive value of K-RAS mutations in non-small cell lung cancer.
Prognostic factors in resected stage I non-small-cell lung cancer: a multivariate analysis of six molecular markers.
Prognostic impact of mutated K-ras gene in surgically resected non-small cell lung cancer patients.
Prognostic role of K-Ras mutations in non-small cell lung cancer: still an issue for open debate.
Prognostic role of Rab27A and Rab27B expression in patients with non-small cell lung carcinoma.
Prognostic significance of K-ras codon 12 mutations in patients with resected stage I and II non-small-cell lung cancer.
Prognostic significance of K-ras, p53, bcl-2, PCNA, CD34 in radically resected non-small cell lung cancers.
Prognostic value of k-ras 12 genotypes in patients with advanced nonsmall cell lung-cancer receiving Carboplatin with either intravenous or chronic oral dose Etoposide.
Prognostic value of K-RAS mutations in patients with non-small cell lung cancer: a systematic review with meta-analysis.
Progress and challenges in selected areas of tobacco carcinogenesis.
Prolonged sulforaphane treatment does not enhance tumorigenesis in oncogenic K-ras and xenograft mouse models of lung cancer.
Promotion of Lung Carcinogenesis by COPD-like Airway Inflammation in a K-ras Induced Mouse Model.
Protein Kinase C {delta} Is a Downstream Effector of Oncogenic K-ras in Lung Tumors.
Prx I suppresses K-ras-driven lung tumorigenesis by opposing redox-sensitive ERK/cyclin D1 pathway.
Quantitative enriched PCR (QEPCR), a highly sensitive method for detection of K-ras oncogene mutation.
Rab37 in lung cancer mediates exocytosis of soluble ST2 and thus skews macrophages toward tumor-suppressing phenotype.
Rab37 mediates exocytosis of secreted frizzled-related protein 1 to inhibit Wnt signaling and thus suppress lung cancer stemness.
RAB38 is a potential prognostic factor for tumor recurrence in non-small cell lung cancer.
Rad GTPase inhibits the NF?B pathway through interacting with RelA/p65 to impede its DNA binding and target gene transactivation.
Radiosensitivity of small-cell lung cancer xenografts compared with activity of c-myc, N-myc, L-myc, c-raf-1 and K-ras proto-oncogenes.
Rap2a serves as a potential prognostic indicator of renal cell carcinoma and promotes its migration and invasion through up-regulating p-Akt.
Rapid detection of K-ras gene mutations in canine lung cancer using single-strand conformational polymorphism analysis.
Ras mutation, irrespective of cell type and p53 status, determines a cell's destiny to undergo apoptosis by okadaic acid, an inhibitor of protein phosphatase 1 and 2A.
Ras mutational status is a biomarker for resistance to EGFR inhibitors in colorectal carcinoma.
Reduced NF1 expression confers resistance to EGFR inhibition in lung cancer.
Regulatory single nucleotide polymorphisms at the beginning of intron 2 of the human KRAS gene.
Relationship of Ras association domain family 1 methylation and K-ras mutation in primary non-small cell lung cancer.
Requirement for Rac1 in a K-ras induced lung cancer in the mouse.
Requirement of the NF-kappaB subunit p65/RelA for K-Ras-induced lung tumorigenesis.
Response to First-Line Chemotherapy in Patients With Non-Small-Cell Lung Cancer According to Epidermal Growth Factor Receptor and K-RAS Mutation Status.
Restoration of mutant K-Ras repressed miR-199b inhibits K-Ras mutant non-small cell lung cancer progression.
Retroviral vector-mediated transduction of K-ras antisense RNA into human lung cancer cells inhibits expression of the malignant phenotype.
Rho GTPase Activating Protein 24 (ARHGAP24) Silencing Promotes Lung Cancer Cell Migration and Invasion by Activating ?-Catenin Signaling.
RHOB expression controls the activity of serine/threonine protein phosphatase PP2A to modulate mesenchymal phenotype and invasion in non-small cell lung cancers.
Risk assessment of space radiation-induced invasive cancer in mouse models of lung and colorectal cancer.
Risk for K-ras gene mutations in smoking-induced lung cancer is associated with cytochrome P4501A1 and glutathione S-transferase micro1 polymorphisms.
Role of epidermal growth factor receptor overexpression, K-ras point mutation and c-myc amplification in the carcinogenesis of non-small cell lung cancer.
RRAD inhibits the Warburg effect through negative regulation of the NF-?B signaling.
Schedule-dependent apoptosis in K-ras mutant non-small-cell lung cancer cell lines treated with docetaxel and erlotinib: rationale for pharmacodynamic separation.
Sex specific function of epithelial STAT3 signaling in pathogenesis of K-ras mutant lung cancer.
Sex-specificity in lung cancer risk.
Single-agent paclitaxel by 3-hour infusion in the treatment of non-small cell lung cancer: links between p53 and K-ras gene status and chemosensitivity.
siRNA-Encapsulated Hybrid Nanoparticles Target Mutant K-ras and Inhibit Metastatic Tumor Burden in a Mouse Model of Lung Cancer.
Somatic activation of the K-ras oncogene causes early onset lung cancer in mice.
Sorafenib in patients with advanced non-small cell lung cancer that harbor K-ras mutations: a brief report.
Sotorasib: First Approval.
Specific inhibition of K-ras expression and tumorigenicity of lung cancer cells by antisense RNA.
Splice switching an oncogenic ratio of SmgGDS isoforms as a strategy to diminish malignancy.
Studies on clinicopathological features of lung cancer patients with K-ras/p53 gene alterations: comparison between younger and older groups.
Sublocalization of Rab23, a mediator of Sonic hedgehog signaling pathway, in hepatocellular carcinoma cell lines.
Suppression of A549 lung cancer cell migration by precursor let-7g microRNA.
Suppression of colorectal cancer growth using an adenovirus vector expressing an antisense K-ras RNA.
Suppression of lung cancer tumor growth in a nude mouse model by the Ras inhibitor salirasib (farnesylthiosalicylic acid).
Suppression of non-small cell lung tumor development by the let-7 microRNA family.
Synchronous double primary lung cancers via p53 pathway induced by heavy smoking.
Synergistic cell growth inhibition by the combination of amrubicin and Akt-suppressing agents in K-ras mutation-harboring lung adenocarcinoma cells: implication of EGFR tyrosine kinase inhibitors.
Synergistic effects of sorafenib in combination with gemcitabine or pemetrexed in lung cancer cell lines with K-ras mutations.
T helper 17 cells play a critical pathogenic role in lung cancer.
Targeting Bcl-2 stability to sensitize cells harboring oncogenic ras.
TBK1 kinase addiction in lung cancer cells is mediated via autophagy of Tax1bp1/Ndp52 and non-canonical NF-?B signalling.
Telomere dysfunction promotes genome instability and metastatic potential in a K-ras p53 mouse model of lung cancer.
The brain microenvironment negatively regulates miRNA-768-3p to promote K-ras expression and lung cancer metastasis.
The Extract of Cordyceps Militaris Inhibited the Proliferation of Cisplatin-Resistant A549 Lung Cancer Cells by Downregulation of H-Ras.
The K-ras gene regulates vascular endothelial growth factor gene expression in non-small cell lung cancers.
The let-7 microRNA reduces tumor growth in mouse models of lung cancer.
The let-7a microRNA protects from growth of lung carcinoma by suppression of k-Ras and c-Myc in nude mice.
The lichen secondary metabolite atranorin suppresses lung cancer cell motility and tumorigenesis.
The presence of Merkel cell polyomavirus is associated with deregulated expression of BRAF and Bcl-2 genes in non-small cell lung cancer.
The Ras inhibitor farnesylthiosalicylic acid (Salirasib) disrupts the spatiotemporal localization of active Ras: a potential treatment for cancer.
The relationship between microvessel count and the expression of vascular endothelial growth factor, p53, and K-ras in non-small cell lung cancer.
The role of induction (neoadjuvant) chemotherapy in stage IIIA NSCLC.
The role of K-Ras gene mutation in TRAIL-induced apoptosis in pancreatic and lung cancer cell lines.
The sensitivity of lung cancer cell lines to the EGFR-selective tyrosine kinase inhibitor ZD1839 ('Iressa') is not related to the expression of EGFR or HER-2 or to K-ras gene status.
The tumor suppressor LKB1 regulates lung cancer cell polarity by mediating cdc42 recruitment and activity.
Therapeutic Efficacy of Lactonic Sophorolipids: Nanoceria-Assisted Combination Therapy of NSCLC using HDAC and Hsp90 Inhibitors.
Tissue factor expression in non-small cell lung cancer: relationship with vascular endothelial growth factor expression, microvascular density, and K-ras mutation.
Toxicology and Carcinogenesis Studies of Cumene (CAS No. 98-82-8) in F344/N Rats and B6C3F1 Mice (Inhalation Studies).
TUCR.454 inhabits metastasis in lung cancer cells.
Tumor necrosis factor links chronic obstructive pulmonary disease and K-ras mutant lung cancer through induction of an immunosuppressive pro-tumor microenvironment.
Type of TP53 mutation influences oncogenic potential and spectrum of associated K-ras mutations in lung-specific transgenic mice.
Understanding and re-engineering nucleoprotein machines to cure human disease.
Understanding the Complexity of the Tumor Microenvironment in K-ras Mutant Lung Cancer: Finding an Alternative Path to Prevention and Treatment.
Urine Proteome Profiling Predicts Lung Cancer from Control Cases and Other Tumors.
Use of K-Ras as a predictive biomarker for selecting anti-EGF receptor/pathway treatment.
Use of molecular markers for predicting therapy response in cancer patients.
VAMP8, a vesicle-SNARE required for RAB37-mediated exocytosis, possesses a tumor metastasis suppressor function.
Vascular endothelial growth factor and nitric oxide synthase expression in human lung cancer and the relation to p53.
Vascular endothelial growth factor and other biological predictors related to the postoperative survival rate on non-small cell lung cancer.
VEGF neutralizing aerosol therapy in primary pulmonary adenocarcinoma with K-ras activating-mutations.
Vimentin regulates lung cancer cell adhesion through a VAV2-Rac1 pathway to control focal adhesion kinase activity.
[A new cell line derived from a nude mouse resembling human large cell lung cancer]
[A simple look at the molecular biology of lung cancer: K-Ras]
[Ablation of p120-Catenin Altering the Activity of Small GTPase in Human Lung Cancer Cells.]
[Analysis of oncogenes and suppressor genes in lung cancer and bronchial lesions from high risk group]
[Construction of let-7a expression plasmid and its inhibitory effect on k-Ras protein in A549 lung cancer cells].
[Correlation of expression of p120ctn , RhoA and Cdc42 and their significance in non-small cell lung cancer.]
[Detection of EGFR and K-ras mutations in non-small cell lung cancer using cytological specimens].
[Detection of K-ras mutation from malignant cells in sputum with mutant-allele specific amplification (MASA) method]
[Detection of K-ras oncogene activation in human lung cancer and its possible clinical application]
[Detection of K-ras oncogene mutations in human lung cancer by PCR-SSCP-DNA direct sequencing]
[Detection of oncogenic mutations in sputum and its diagnostic value of lung cancer]
[Detection of P53 and K-ras gene mutations in lung cancer with oligonucleotide chip]
[Enhanced growth inhibition by combined two pathway inhibitors on K-ras mutated non-small cell lung cancer cells].
[Erratum: Identification Analysis of Eukaryotic Expression Plasmid Rap2a and Its Effect on the Migration of Lung Cancer Cells].
[Establishment and its biological characteristics of patient-derived lung cancer xenograft models]
[Evidence on the carcinogenicity of silica at DNA level in human]
[Expression and clinical significance of caspase-3,survivin and k-ras in non-small cell lung cancer.]
[Expression of surviving gene and its relationship with expression of P53, c-myc, k-ras proteins in non-small-cell lung cancer]
[Expressions of 8-OH-dG, k-ras, and p53 genes in pleural effusion cells and their clinical significances]
[Genetic abnormalities in lung cancer and their prognostic implications]
[Identification analysis of eukaryotic expression plasmid Rap2a and its effect on the migration of lung cancer cells].
[K-RAS gene mutations in patients with non-small cell lung cancer]
[K-ras gene mutations of asbestos and welding-fumes related human lung cancer]
[K-ras mutation predictive significance in platinum based chemotherapeutic protocols in patients with advanced non-small cell lung cancer]
[Lung cancer]
[Mutational analysis of EGFR and K-RAS in Chinese patients with non-small cell lung cancer]
[Relationship between EGFR and K-ras mutations and clinicopathological characteristics and response to erlotinib treatment in 301 Chinese patients with non-small cell lung cancer].
[Relationship between the protein expression of ERCC1, BRCA, ?-tubulin and K-ras and the efficacy and prognosis in advanced non-small cell lung cancer].
[Research advances of K-ras mutation in the prognosis and targeted therapy of gastric cancer].
[Reversal of pulmonary hypertrophic osteoarthropathy in surgically treated lung cancer].
[Screening for K-ras mutations in colorectal and lung cancers by using a novel real-time PCR with ADx-K-ras kit and Sanger DNA sequencing].
[Sequencing analysis of human K-ras oncogene exon 1 in Chinese people]
[Study of 8-OH-dG and its correlation with several cancer related gene in lung cancer tissues]
[Study of growth inhibition of lung cancer cells by siRNA targeting mutant K-ras gene in vitro and in vivo]
[Study on point mutations of K-ras gene in non-small cell lung cancer in Guangxi].
[Study on the mutations of p53 and K-ras gene in the cancer tissues and sputum cells of patients with lung cancer.]
[Synchronous Multiple Primary Lung Cancer Dignosed ?by Different Phenotype-genotype: A Case Report and Literature Review].
[The Expression of COX-2 in Human Lung Cancer and its Relationship with Expression of K-ras and Mcl-1.]
[The expressions of K-ras in human laryngeal squamous cell carcinoma cell lines (Hep-2) and its significance]
[The relationship between smoking and p53 and Ki-ras gene mutations in sputum cells of patients with lung cancer.]
[The role of the constitutional features and rearrangement of the H-ras 1 oncogene in the development of human lung cancer]
[The study of correlation between the K-ras genotype and murine susceptibility to chemically induced lung neoplasms]
Lupus Erythematosus, Systemic
Signal transduction pathways in chronic inflammatory autoimmune disease: small GTPases.
Lyme Disease
Borrelia burgdorferi elongation factor EF-Tu is an immunogenic protein during Lyme borreliosis.
Lymphatic Metastasis
Analysis of microsatellite instability, K-ras gene mutation and p53 protein overexpression in intrahepatic cholangiocarcinoma.
Association of matrilysin mRNA expression with K-ras mutations and progression in pancreatic ductal adenocarcinomas.
Clinical significance of K-ras and c-erbB-2 mutations in pancreatic adenocarcinoma and chronic pancreatitis.
Clinicopathological pattern and Annexin A2 and Cdc42 status in patients presenting with differentiation and lymphnode metastasis of esophageal squamous cell carcinomas.
Co-mutation of p53, K-ras genes and accumulation of p53 protein and its correlation to clinicopathological features in rectal cancer.
Comparison of K-ras gene mutations in tumour and sputum DNA of patients with lung cancer.
Correlation of COX-2 and K-ras expression to clinical outcome in gastric cancer.
Curative resection of hilar cholangiocarcinoma in a 25-year-old woman: report of a case.
Detection of K-ras mutations in the plasma DNA of pancreatic cancer patients.
Detection of mutated K12-ras in histologically negative lymph nodes as an indicator of poor prognosis in stage II colorectal cancer.
Downregulation of RECK by promoter methylation correlates with lymph node metastasis in non-small cell lung cancer.
Effect of the secretory small GTPase Rab27B on breast cancer growth, invasion, and metastasis.
ERM/Rho protein expression in ductal breast cancer: a 15 year follow-up.
Expression analysis of Cdc42 in lung cancer and modulation of its expression by curcumin in lung cancer cell lines.
Expression of P21-activated kinase 1 and cell division control protein 42 homolog correlates with clinicopathological features and prognosis in cervical carcinoma.
Fast simultaneous detection of K-RAS mutations in colorectal cancer.
Filamin C promotes lymphatic invasion and lymphatic metastasis and increases cell motility by regulating Rho GTPase in esophageal squamous cell carcinoma.
Genetic Alterations of K-ras, p53, c-erbB-2, and DPC4 in Pancreatic Ductal Adenocarcinoma and Their Correlation With Patient Survival.
Genetic diagnosis identifies occult lymph node metastases undetectable by the histopathological method.
Heterogeneous distribution of K-ras mutations in primary colon carcinomas: implications for EGFR-directed therapy.
High Rab27A expression indicates favorable prognosis in CRC.
Immunohistochemical evaluation of P21ras and P53 proteins expression in human non-small-cell lung cancers.
Immunoperoxidase staining for cytokeratins 8 and 18 is very sensitive for detection of occult node metastasis of colorectal cancer: a comparison with genetic analysis of K-ras.
K-ras mutation is an early event in pancreatic duct carcinogenesis in the Syrian golden hamster.
K-ras mutations are correlated to lymph node metastasis and tumor stage, but not to the growth pattern of colon carcinoma.
K-ras point mutations in endometrial carcinoma: effect on outcome is dependent on age of patient.
Keratin 20 is a specific marker of submicroscopic lymph node metastases in colorectal cancer: validation by K-RAS mutations.
Loss of a reporter gene for green fluorescent protein during tumor progression suggests the recruitment of host cells in rats with experimentally induced colon cancer.
Loss of heterozygosity and microsatellite instability of the h-ras gene in cancer of the head and neck.
MiR-196a binding-site SNP regulates RAP1A expression contributing to esophageal squamous cell carcinoma risk and metastasis.
Overexpression of MEKK2 is associated with colorectal carcinogenesis.
Overexpression of Rab27B is correlated with distant metastasis and poor prognosis in ovarian cancer.
Overexpression of the secretory small GTPase Rab27B in human breast cancer correlates closely with lymph node metastasis and predicts poor prognosis.
Prognostic factors of colorectal cancer: K-ras mutation, overexpression of the p53 protein, and cell proliferative activity.
Prognostic significance of Rab27 expression in solid cancer: a systematic review and meta-analysis.
Rab11 collaborates E-cadherin to promote collective cell migration and indicates a poor prognosis in colorectal carcinoma.
Rab27b Is a Potential Indicator for Lymph Node Metastasis and Unfavorable Prognosis in Lung Adenocarcinoma.
Rab27b is a potential predictor for metastasis and prognosis in colorectal cancer.
ras gene mutations in ethmoid sinus adenocarcinoma: prognostic implications.
Re. article entitled 'Keratin 20 is a specific marker of submicroscopic lymph node metastases in colorectal cancer: validation by K-RAS mutations'.
The prognostic significance of p63 cytoplasmic expression in colorectal cancer. An immunohistochemical study.
The relationship between microvessel count and the expression of vascular endothelial growth factor, p53, and K-ras in non-small cell lung cancer.
The secretory small GTPase Rab27B as a marker for breast cancer progression.
[Association of mutations of K-RAS oncogene and deletions of 18Q with lymph node metastasis of colorectal cancer]
[Clinical significance of p21H-ras expression and H-ras codon 12 mutation in squamous intraepithelial lesion (SIL) and carcinoma of uterine cervix]
Lymphocytic Choriomeningitis
Identification and characterization of a novel broad spectrum virus entry inhibitor.
Lymphohistiocytosis, Hemophagocytic
A Griscelli syndrome type 2 murine model of hemophagocytic lymphohistiocytosis (HLH).
A Heterozygous RAB27A Mutation Associated with Delayed Cytolytic Granule Polarization and Hemophagocytic Lymphohistiocytosis.
A Novel CDC42 Mutation in an 11-Year Old Child Manifesting as Syndromic Immunodeficiency, Autoinflammation, Hemophagocytic Lymphohistiocytosis, and Malignancy: A Case Report.
A RAB27A 5'UTR structural variant associated with late-onset hemophagocytic lymphohistiocytosis and normal pigmentation.
Different NK cell activating receptors preferentially recruit Rab27a or Munc13-4 to perforin-containing granules for cytotoxicity.
Evidence for defective Rab GTPase-dependent cargo traffic in immune disorders.
Evidence that Griscelli syndrome with neurological involvement is caused by mutations in RAB27A, not MYO5A.
Genetic loci contributing to hemophagocytic lymphohistiocytosis do not confer susceptibility to systemic-onset juvenile idiopathic arthritis.
Griscelli syndrome: report of the first peripheral blood stem cell transplant and the role of mutations in the RAB27A gene as an indication for BMT.
Hematopoietic stem cell transplantation in children with Griscelli Syndrome type 2: Experience and outcomes.
Hemophagocytic lymphohistiocytosis and related disorders.
MUNC13-4 protein regulates the oxidative response and is essential for phagosomal maturation and bacterial killing in neutrophils.
Mutation spectrum in children with primary hemophagocytic lymphohistiocytosis: molecular and functional analyses of PRF1, UNC13D, STX11, and RAB27A.
NK cytotoxicity mediated by CD16 but not by NKp30 is functional in Griscelli syndrome.
Oral features of Griscelli syndrome type II: A rare case report.
Pulmonary lymphomatoid granulomatosis in Griscelli syndrome type 2.
Rab27a negatively regulates phagocytosis by prolongation of the actin-coating stage around phagosomes.
Synaptotagmin-like protein 5: a novel Rab27A effector with C-terminal tandem C2 domains.
The munc13-4-rab27 complex is specifically required for tethering secretory lysosomes at the plasma membrane.
The Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2 functions as a novel Rab27A binding domain.
[Defect in lytic granule exocytosis : several causes, a same effect.]
Lymphoma
A unique carboxyl-terminal insert domain in the hematopoietic-specific, GTPase-deficient Rho GTPase RhoH regulates post-translational processing.
Activation of clg, a novel dbl family guanine nucleotide exchange factor gene, by proviral insertion at evi24, a common integration site in B cell and myeloid leukemias.
Activation of K-ras by codon 13 mutations in C57BL/6 X C3H F1 mouse tumors induced by exposure to 1,3-butadiene.
Activation of protooncogenes in spontaneously occurring non-liver tumors from C57BL/6 x C3H F1 mice.
An overexpressed N-ras proto-oncogene cooperates with N-methylnitrosourea in mouse mammary carcinogenesis.
Analysis of p53, K-ras, c-kit, and beta-catenin gene mutations in sinonasal NK/T cell lymphoma in northeast district of China.
Anaplastic lymphoma kinase activates the small GTPase Rap1 via the Rap1-specific GEF C3G in both neuroblastoma and PC12 cells.
Characteristic association between K-ras gene mutation with loss of heterozygosity in X-ray-induced thymic lymphomas of the B6C3F1 mouse.
Combined Inactivation of MYC and K-Ras oncogenes reverses tumorigenesis in lung adenocarcinomas and lymphomas.
Cooperative alterations of Rb pathway regulators in mouse primary T cell lymphomas.
Degradation of Tiam1 by casein kinase 1 and the SCF?TrCP ubiquitin ligase controls the duration of mTOR-S6K signaling.
Differential expression of the normal and mutated K-ras alleles in chemically induced thymic lymphomas.
Exosomes secreted from cancer-associated fibroblasts elicit anti-pyrimidine drug resistance through modulation of its transporter in malignant lymphoma.
Expression of miR-34a and miR-15b during the progression of cervical cancer in a murine model expressing the HPV16 E7 oncoprotein.
Expression of the 6C3 antigen on murine hematopoietic neoplasms. Association with expression of abl, ras, fes, src, erbB, and Cas NS-1 oncogenes but not with myc.
Gene mutation analysis of sinonasal lymphomas in Indonesia.
Gene mutations in lymphoproliferative disorders of T and NK/T cell phenotypes developing in renal transplant patients.
Genetic susceptibility to thymic lymphomas and K-ras gene mutation in mice after exposure to X-rays and N-ethyl-N-nitrosourea.
H-RAS point mutations in leukaemias and lymphomas.
Helicobacter pylori eradication therapy for high-grade mucosa-associated lymphoid tissue lymphomas of the stomach with analysis of p53 and K-ras alteration and microsatellite instability.
Induction of mammary cancer and lymphoma by multiple, low oral doses of 7,12-dimethylbenz[a]anthracene in SENCAR mice.
Influence of sex and carcinogen treatment protocol on tumor latency and frequency of K-ras mutations in N-methyl-N-nitrosourea-induced lymphomas.
Inhibition of Rac controls NPM-ALK-dependent lymphoma development and dissemination.
K-ras point mutations in the supernatants of pancreatic juice and bile are reliable for diagnosis of pancreas and biliary tract carcinomas complementary to cytologic examination.
Lymphomagenesis in E mu-myc transgenic mice can involve ras mutations.
Mice over-expressing human O6 alkylguanine-DNA alkyltransferase selectively reduce O6 methylguanine mediated carcinogenic mutations to threshold levels after N-methyl-N-nitrosourea.
Microsatellite instability and k-ras, p53 mutations in thyroid lymphoma.
Molecular profiling to optimize treatment in non-small cell lung cancer: a review of potential molecular targets for radiation therapy by the translational research program of the radiation therapy oncology group.
Mutations of p53, c-kit, K-ras, and beta-catenin gene in non-Hodgkin's lymphoma of adrenal gland.
Mutations of ras protooncogenes and p53 tumor suppressor gene in cardiac hemangiosarcomas from B6C3F1 mice exposed to 1,3-butadiene for 2 years.
p53, K-ras, c-kit and beta-catenin gene mutations in sinonasal NK/T-cell lymphoma in Korea and Japan.
P53, N- and K-Ras, and beta-catenin gene mutations and prognostic factors in nasal NK/T-cell lymphoma from Hokkaido, Japan.
Potentiation of lymphomagenesis by methylnitrosourea in mice transgenic for LMO1 is blocked by O6-alkylguanine DNA-alkyltransferase.
Rac1 targeting suppresses p53 deficiency-mediated lymphomagenesis.
Radiation and chemical activation of ras oncogenes in different mouse strains.
ras activation in human tumors and in animal model systems.
ras oncogenes and phenotypic staging in N-methylnitrosourea- and gamma-irradiation-induced thymic lymphomas in C57BL/6J mice.
Recruitment of Tiam1 to Semaphorin 4D Activates Rac and Enhances Proliferation, Invasion, and Metastasis in Oral Squamous Cell Carcinoma.
Recurrent intragenic exon rearrangements of SOBP and AUTS2 in non-Hodgkin B-cell lymphoma.
Redundant and nonredundant roles for Cdc42 and Rac1 in lymphomas developed in NPM-ALK transgenic mice.
Sialylation and glycosylation modulate cell adhesion and invasion to extracellular matrix in human malignant lymphoma: Dependency on integrin and the Rho GTPase family.
The anaplastic lymphoma kinase controls cell shape and growth of anaplastic large cell lymphoma through Cdc42 activation.
The Influence of Biomarker Mutations and Systemic Treatment on Cerebral Metastases from NSCLC Treated with Radiosurgery.
The utility of cytology in the diagnosis of adenocarcinoma lung: A tertiary care center study.
Transgenic expression of human MGMT blocks the hypersensitivity of PMS2-deficient mice to low dose MNU thymic lymphomagenesis.
Upregulated TRIO expression correlates with a malignant phenotype in human hepatocellular carcinoma.
Use of E mu-PIM-1 transgenic mice short-term in vivo carcinogenicity testing: lymphoma induction by benzo[a]pyrene, but not by TPA.
Wiskott-Aldrich syndrome protein (WASP) is a tumor suppressor in T cell lymphoma.
Lymphoma, B-Cell
A one-step DGGE scanning method for detection of mutations in the K-, N-, and H-ras oncogenes: mutations at codons 12, 13 and 61 are rare in B-cell non-Hodgkin's lymphoma.
Expression of miR-34a and miR-15b during the progression of cervical cancer in a murine model expressing the HPV16 E7 oncoprotein.
p53 expression, K-ras gene mutation and microsatellite instability in gastric B-cell lymphomas.
Recurrent intragenic exon rearrangements of SOBP and AUTS2 in non-Hodgkin B-cell lymphoma.
Targeting Rac and Cdc42 GEFs in Metastatic Cancer.
Upregulated TRIO expression correlates with a malignant phenotype in human hepatocellular carcinoma.
Lymphoma, B-Cell, Marginal Zone
Helicobacter pylori eradication therapy for high-grade mucosa-associated lymphoid tissue lymphomas of the stomach with analysis of p53 and K-ras alteration and microsatellite instability.
Lymphoma, Large B-Cell, Diffuse
A one-step DGGE scanning method for detection of mutations in the K-, N-, and H-ras oncogenes: mutations at codons 12, 13 and 61 are rare in B-cell non-Hodgkin's lymphoma.
Lymphoma, Large-Cell, Anaplastic
Inhibition of Rac controls NPM-ALK-dependent lymphoma development and dissemination.
Redundant and nonredundant roles for Cdc42 and Rac1 in lymphomas developed in NPM-ALK transgenic mice.
The anaplastic lymphoma kinase controls cell shape and growth of anaplastic large cell lymphoma through Cdc42 activation.
Lymphoma, Non-Hodgkin
A one-step DGGE scanning method for detection of mutations in the K-, N-, and H-ras oncogenes: mutations at codons 12, 13 and 61 are rare in B-cell non-Hodgkin's lymphoma.
Association between C-myc and K-ras gene polymorphisms and non-Hodgkin lymphoma.
Detection of K-ras mutations in stools of patients with colorectal cancer by mutant-enriched PCR.
H-RAS 1 minisatellite rare alleles: a genetic susceptibility and prognostic factor for non-Hodgkin's lymphoma.
Mutations of p53, c-kit, K-ras, and beta-catenin gene in non-Hodgkin's lymphoma of adrenal gland.
Lymphoma, T-Cell
Dasatinib is an effective treatment for angioimmunoblastic T-cell lymphoma.
Redundant and nonredundant roles for Cdc42 and Rac1 in lymphomas developed in NPM-ALK transgenic mice.
Roles of GTP and Rho GTPases in pancreatic islet beta cell function and dysfunction.
Timing of Novel Drug 1A-116 to Circadian Rhythms Improves Therapeutic Effects against Glioblastoma.
Lymphoma, T-Cell, Peripheral
Gene mutations in lymphoproliferative disorders of T and NK/T cell phenotypes developing in renal transplant patients.
Lymphoproliferative Disorders
Hemophagocytic lymphohistiocytosis and related disorders.
Oncogene expression in T-cell lymphoproliferative disorders.
Pediatric Hemophagocytic Lymphohistiocytosis (HLH).
Machado-Joseph Disease
cDNA cloning and tissue expression analyses of the encoding regions for three novel porcine genes- MJD1, CDC42 and NECD.
Macular Degeneration
CCL24 contributes to HCC malignancy via RhoB- VEGFA-VEGFR2 angiogenesis pathway and indicates poor prognosis.
cGMP-dependent protein kinase phosphorylates p21-activated kinase (Pak) 1, inhibiting Pak/Nck binding and stimulating Pak/vasodilator-stimulated phosphoprotein association.
Malaria
Rab GTPase regulation of bacteria and protozoa phagocytosis occurs through the modulation of phagocytic receptor surface expression.
Structures of PI4KIII? complexes show simultaneous recruitment of Rab11 and its effectors.
Megalencephaly
Cerebral organoid and mouse models reveal a RAB39b-PI3K-mTOR pathway-dependent dysregulation of cortical development leading to macrocephaly/autism phenotypes.
Mutations in the small GTPase gene RAB39B are responsible for X-linked mental retardation associated with autism, epilepsy, and macrocephaly.
Recurrent ?100 Kb microdeletion in the chromosomal region 14q11.2, involving CHD8 gene, is associated with autism and macrocephaly.
Melanoma
5-Arylidene(chromenyl-methylene)-thiazolidinediones: Potential New Agents against Mutant Oncoproteins K-Ras, N-Ras and B-Raf in Colorectal Cancer and Melanoma.
A comprehensive genome-wide analysis of melanoma Breslow thickness identifies interaction between CDC42 and SCIN genetic variants.
A disconnect between antitumor and antiangiogenic effects of fluvastatin in vitro and in vivo.
A Targeted Quantitative Proteomic Approach Assesses the Reprogramming of Small GTPases during Melanoma Metastasis.
Abrogation of RAB27A expression transiently affects melanoma cell proliferation.
Absence of ras gene mutations in UV-induced malignant melanomas correlates with a dermal origin of melanocytes in Monodelphis domestica.
Absence of ras-gene hot-spot mutations in canine fibrosarcomas and melanomas.
Activation of small GTPase Rho is required for autocrine motility factor signaling.
ADP-ribosylation factor 6 regulates tumor cell invasion through the activation of the MEK/ERK signaling pathway.
An integrated approach to uncover drivers of cancer.
Analysis of mutations in B-RAF, N-RAS, and H-RAS genes in the differential diagnosis of Spitz nevus and spitzoid melanoma.
Analysis of N- and K-ras mutations in the distinctive tumor progression phases of melanoma.
beta-catenin mutations are absent in hepatocellular carcinomas of SV40 T-antigen transgenic mice.
Binimetinib in heavily pretreated NRAS-mutant Melanoma Patients with Brain Metastases.
Blockage of transferred exosome-shuttled miR-494 inhibits melanoma growth and metastasis.
Blocking oncogenic Ras signaling for cancer therapy.
Cdc42 and Rac1 are necessary for autotaxin-induced tumor cell motility in A2058 melanoma cells.
Chemotherapy for advanced adrenal cancer: improvement from a molecular approach?
Circ_0013359 facilitates the tumorigenicity of melanoma by regulating miR-136-5p/RAB9A axis.
Components of the Rb pathway are critical targets of UV mutagenesis in a murine melanoma model.
Decreased expressions of c-myc and H-ras oncogenes in vitamin E succinate induced morphologically differentiated murine B-16 melanoma cells in culture.
DOCK10-mediated Cdc42 activation is necessary for amoeboid invasion of melanoma cells.
Dynamic regulation of endolysosomal programs drives melanoma progression.
Exoenzyme C3 transferase lowers actin cytoskeleton dynamics, genomic stability and survival of malignant melanoma cells under UV-light stress.
Expression of p21 ras protein in human melanoma cell lines.
Genetic and epigenetic loss of microRNA-31 leads to feed-forward expression of EZH2 in melanoma.
Genetic similarities between Spitz nevus and Spitzoid melanoma in children.
H-ras ribozyme-mediated alteration of the human melanoma phenotype.
Hippo-independent activation of YAP by the GNAQ uveal melanoma oncogene through a trio-regulated rho GTPase signaling circuitry.
Impact of point mutation P29S in RAC1 on tumorigenesis.
In vivo assessment of RAS-dependent maintenance of tumor angiogenesis by real-time magnetic resonance imaging.
Induction of different morphologic features of malignant melanoma and pigmented lesions after transformation of murine melanocytes with bFGF-cDNA and H-ras, myc, neu, and E1a oncogenes.
Involvement of E-cadherin, beta-catenin, Cdc42 and CXCR4 in the progression and prognosis of cutaneous melanoma.
LKB1/STK11 inactivation leads to expansion of a prometastatic tumor subpopulation in melanoma.
Long non-coding RNA NEAT1 promotes tumor development and metastasis through targeting RAB9A in malignant melanoma.
Long Noncoding RNA LUADT1 Is Upregulated in Melanoma and May Sponge miR-28-5p to Upregulate RAP1B.
Long noncoding RNA RHPN1-AS1 promotes colorectal cancer progression via targeting miR-7-5p/OGT axis.
Long noncoding RNA ZFAS1 promotes tumorigenesis through regulation of miR-150-5p/RAB9A in melanoma.
Low level electricity increases the secretion of extracellular vesicles from cultured cells.
Melanoma chondroitin sulphate proteoglycan regulates cell spreading through Cdc42, Ack-1 and p130cas.
Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET.
Microphthalmia-associated transcription factor regulates RAB27A gene expression and controls melanosome transport.
Molecular cloning and characterization of rab27a and rab27b, novel human rab proteins shared by melanocytes and platelets.
NecroX-5 Can Suppress Melanoma Metastasis by Reducing the Expression of Rho-Family GTPases.
Neratinib and entinostat combine to rapidly reduce the expression of K-RAS, N-RAS, G?q and G?11 and kill uveal melanoma cells.
NFATc2 is an intrinsic regulator of melanoma dedifferentiation.
Non-canonical EphA2 signaling is a driver of tumor-endothelial cell interactions and metastatic dissemination in BRAF inhibitor resistant melanoma.
Overexpression of mutant ras in human melanoma increases invasiveness, proliferation and anchorage-independent growth in vitro and induces tumour formation and cachexia in vivo.
Pentoxifylline impedes migration in B16F10 melanoma by modulating Rho GTPase activity and actin organisation.
Photobiology and genetics of malignant melanoma.
Pro-metastatic signaling by c-Met through RAC-1 and reactive oxygen species (ROS).
Procathepsin L secretion, which triggers tumour progression, is regulated by Rab4a in human melanoma cells.
RAB27A promotes melanoma cell invasion and metastasis via regulation of pro-invasive exosomes.
Rab33A: Characterization, Expression, and Suppression by Epigenetic Modification.
RAB7 controls melanoma progression by exploiting a lineage-specific wiring of the endolysosomal pathway.
Ras mutations in human melanoma: a marker of malignant progression.
ras mutations in human melanotic lesions: K-ras activation is a frequent and early event in melanoma development.
Ras oncoproteins transfer from melanoma cells to T cells and modulate their effector functions.
Reduced WNT5A signaling in melanoma cells favors an amoeboid mode of invasion.
Rho-GTPase signaling drives melanoma cell plasticity.
RhoJ modulates melanoma invasion by altering actin cytoskeletal dynamics.
RIAM controls invasion and growth of melanoma cells.
RNAi-mediated knockdown of protein kinase C-alpha inhibits cell migration in MM-RU human metastatic melanoma cell line.
Role of ING4 in human melanoma cell migration, invasion and patient survival.
Serological cloning of a melanocyte rab guanosine 5'-triphosphate-binding protein and a chromosome condensation protein from a melanoma complementary DNA library.
Small Gtpase rab3A is associated with melanosomes in melanoma cells.
Soft matrices downregulate FAK activity to promote growth of tumor-repopulating cells.
Somatic p16(INK4a) loss accelerates melanomagenesis.
SOX9 is a dose-dependent metastatic fate determinant in melanoma.
Stress-induced proteins in immune response to cancer.
Stromal cell-derived factor-1alpha promotes melanoma cell invasion across basement membranes involving stimulation of membrane-type 1 matrix metalloproteinase and Rho GTPase activities.
Structure based drug discovery of Rab38 protein- Identification of antagonists as cancer drug candidates.
Suppression of the malignant phenotype of melanoma cells by anti-oncogene ribozymes.
Suppression of the neoplastic phenotype in vivo by an anti-ras ribozyme.
Targeting effector pathways in RAC1P29S-driven malignant melanoma.
Targeting Rac and Cdc42 GTPases in Cancer.
TCL/RhoJ Plasma Membrane Localization and Nucleotide Exchange Is Coordinately Regulated by Amino Acids within the N Terminus and a Distal Loop Region.
The Antitumor Effect of Lipophilic Bisphosphonate BPH1222 in Melanoma Models: The Role of the PI3K/Akt Pathway and the Small G Protein Rheb.
The Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2 functions as a novel Rab27A binding domain.
The Small GTPase ARF6 Activates PI3K in Melanoma to Induce a Prometastatic State.
The Small GTPase ARF6 Stimulates ?-Catenin Transcriptional Activity During WNT5A-Mediated Melanoma Invasion and Metastasis.
Tissue-specific expression of an anti-ras ribozyme inhibits proliferation of human malignant melanoma cells.
Melanoma, Amelanotic
Spontaneous uveal amelanotic melanoma in transgenic Tyr-RAS+ Ink4a/Arf-/- mice.
Melanoma, Experimental
Evidence that the small GTPase Rab8 is involved in melanosome traffic and dendrite extension in B16 melanoma cells.
Inhibition of B16 melanoma cell proliferation and alterations in p21 ras expression induced by interceptors of signal transduction pathways.
RPEL-family rhoGAPs link Rac/Cdc42 GTP loading to G-actin availability.
The bisphosphonate zoledronic acid decreases tumor growth in bone in mice with defective osteoclasts.
Melioidosis
Immunospecific responses to bacterial elongation factor Tu during Burkholderia infection and immunization.
Memory Disorders
Forebrain depletion of Rheb GTPase elicits spatial memory deficits in mice.
Upregulation of miR-137 protects anesthesia-induced hippocampal neurodegeneration.
Meningioma
Loss-of-Function Mutations in TRAF7 and KLF4 Cooperatively Activate RAS-Like GTPase Signaling and Promote Meningioma Development.
Meningitis
CSF Levels of Elongation Factor Tu Is Associated With Increased Mortality in Malawian Adults With Streptococcus pneumoniae Meningitis.
Meningitis, Cryptococcal
Cryptococcus neoformans activates RhoGTPases followed by PKC, FAK and ezrin to enhance traversal across the blood-brain barrier.
Meningomyelocele
Amniotic fluid transcriptomics reflects novel disease mechanisms in fetuses with myelomeningocele.
Menkes Kinky Hair Syndrome
[Hypomelanoses transmitted from generation to generation].
Mental Retardation, X-Linked
Evidence that a major site of expression of the RHO-GTPASE activating protein, oligophrenin-1, is peripheral myelin.
Mutations in the small GTPase gene RAB39B are responsible for X-linked mental retardation associated with autism, epilepsy, and macrocephaly.
[Anassociation study between OPHN1 gene rs492933 polymorphism and mental retardation in children of the Qinba Mountain region.]
Mesothelioma
Analysis of K-ras and p53 mutations in mesotheliomas from humans and rats exposed to asbestos.
Bisphosphonates inhibit the growth of mesothelioma cells in vitro and in vivo.
Differential effects of Ca(2+) on bisphosphonate-induced growth inhibition in breast cancer and mesothelioma cells.
Molecular biology studies on mesothelioma tumor samples: preliminary data on H-ras, p21, and SV40.
p53 and Kirsten-ras mutations in human mesothelioma cell lines.
Well-differentiated papillary mesothelioma of the peritoneum is genetically defined by mutually exclusive mutations in TRAF7 and CDC42.
Mesothelioma, Malignant
Immunohistochemical staining of ras oncogene product in neoplastic and non-neoplastic mesothelial tissues: immunoreactivity for N-ras and lack of immunohistochemical staining for Ha-ras and K-ras.
Molecular biology studies on mesothelioma tumor samples: preliminary data on H-ras, p21, and SV40.
Well-differentiated papillary mesothelioma of the peritoneum is genetically defined by mutually exclusive mutations in TRAF7 and CDC42.
Metabolic Syndrome
Contextual inhibition of fatty acid synthesis by metformin involves glucose-derived acetyl-CoA and cholesterol in pancreatic tumor cells.
Opposing roles of nitric oxide and rho-kinase in lipid metabolism in mice.
Mevalonate Kinase Deficiency
An Update on Autoinflammatory Diseases: Inflammasomopathies.
Microcephaly
Rab18 Collaborates with Rab7 to Modulate Lysosomal and Autophagy Activities in the Nervous System: an Overlapping Mechanism for Warburg Micro Syndrome and Charcot-Marie-Tooth Neuropathy Type 2B.
Microphthalmos
Rap1 GTPase is required for mouse lens epithelial maintenance and morphogenesis.
Motor Neuron Disease
Loss of endosomal recycling factor RAB11 coupled with complex regulation of MAPK/ERK/AKT signaling in postmortem spinal cord specimens of sporadic amyotrophic lateral sclerosis patients.
Mouth Neoplasms
Detection of a rare point mutation at codon 59 and relatively high incidence of H-ras mutation in Indian oral cancer.
Detection of two novel mutations and relatively high incidence of H-RAS mutations in Vietnamese oral cancer.
H-ras and c-fos exhibit similar expression patterns during most stages of oral oncogenesis.
H-ras oncogene mutation and human papillomavirus infection in oral carcinomas.
High frequency mutation in codons 12 and 61 of H-ras oncogene in chewing tobacco-related human oral carcinoma in India.
Influence of single nucleotide polymorphisms in H-Ras and cyclin D1 genes on oral cancer susceptibility.
Mucosal HPV E6/E7 Peptide Vaccination in Combination with Immune Checkpoint Modulation Induces Regression of HPV+ Oral Cancers.
Niclosamide acts as a new inhibitor of vasculogenic mimicry in oral cancer through upregulation of miR-124 and downregulation of STAT3.
S100A7 has an oncogenic role in oral squamous cell carcinoma by activating p38/MAPK and RAB2A signaling pathway.
Understanding and re-engineering nucleoprotein machines to cure human disease.
Urinary-type plasminogen activator receptor (uPAR) modulates oral cancer cell behavior with alteration in p130cas.
Multiple Myeloma
A single-chain Fv diabody against human leukocyte antigen-A molecules specifically induces myeloma cell death in the bone marrow environment.
Activating mutations in the N- and K-ras oncogenes differentially affect the growth properties of the IL-6-dependent myeloma cell line ANBL6.
Activating mutations of N- and K-ras in multiple myeloma show different clinical associations: analysis of the Eastern Cooperative Oncology Group Phase III Trial.
An unusual H-Ras mutant isolated from a human multiple myeloma line leads to transformation and factor-independent cell growth.
Combination of farnesyltransferase and Akt inhibitors is synergistic in breast cancer cells and causes significant breast tumor regression in ErbB2 transgenic mice.
Correlated flow cytometric analysis of H-ras p21 and nuclear DNA in multiple myeloma.
Detection of N-Ras codon 61 mutations in subpopulations of tumor cells in multiple myeloma at presentation.
Downstream effectors of oncogenic ras in multiple myeloma cells.
High incidence of N and K-Ras activating mutations in multiple myeloma and primary plasma cell leukemia at diagnosis.
Histone deacetylase inhibition in combination with MEK or BCL-2 inhibition in multiple myeloma.
Identification of translocation products but not K-RAS mutations in memory B cells from patients with multiple myeloma.
Morphoproteomic expression of H-ras (p21ras) correlates with serum monoclonal immunoglobulin reduction in multiple myeloma patients following pamidronate treatment.
N-RAS and K-RAS gene mutations in Brazilian patients with multiple myeloma.
Olefin Isomers of a Triazole Bisphosphonate Synergistically Inhibit Geranylgeranyl Diphosphate Synthase.
Proliferation of IL-6-independent multiple myeloma does not require the activity of extracellular signal-regulated kinases (ERK1/2).
Rational Targeting of Cdc42 Overcomes Drug Resistance of Multiple Myeloma.
Reduction of serum IGF-I levels in patients affected with Monoclonal Gammopathies of undetermined significance or Multiple Myeloma. Comparison with bFGF, VEGF and K-ras gene mutation.
The proliferation of multiple myeloma colonies (MY-CFUc) in vitro is independent of prognosis and is not associated with mutated N- or K-ras alleles in human bone marrow aspirates.
The small GTPase Ral mediates SDF-1-induced migration of B cells and multiple myeloma cells.
The small GTPase RhoU lays downstream of JAK/STAT signaling and mediates cell migration in multiple myeloma.
[Application of flow cytometry to the study of hematologic disorders: analysis of oncogene products]
[Flow cytometric analysis of oncogene products]
Multiple Sclerosis
Expression of a T39N mutant Rab32 protein arrests mitochondria movement within neurites of differentiated SH-SY5Y cells.
Small GTPase RAS in multiple sclerosis - exploring the role of RAS GTPase in the etiology of multiple sclerosis.
Multiple System Atrophy
Alpha-synuclein binding to rab3a in multiple system atrophy.
Combined Assessment of Serum Alpha-Synuclein and Rab35 is a Better Biomarker for Parkinson's Disease.
Increased Rab35 expression is a potential biomarker and implicated in the pathogenesis of Parkinson's disease.
Muscle Hypotonia
Bi-allelic Variants in RALGAPA1 Cause Profound Neurodevelopmental Disability, Muscular Hypotonia, Infantile Spasms, and Feeding Abnormalities.
Muscular Atrophy
Cdc42 GTPase-activating protein deficiency promotes genomic instability and premature aging-like phenotypes.
Dystrophin-glycoprotein complex and Ras and Rho GTPase signaling are altered in muscle atrophy.
Muscular Diseases
Statins and skeletal muscles toxicity: from clinical trials to everyday practice.
Muscular Dystrophy, Duchenne
The Xq22 inversion breakpoint interrupted a novel Ras-like GTPase gene in a patient with Duchenne muscular dystrophy and profound mental retardation.
Mycoplasma Infections
High-level expression of H-ras and c-myc oncogenes in mycoplasma-mediated malignant cell transformation.
Mycoses
CARD9 mediates Dectin-1-induced ERK activation by linking Ras-GRF1 to H-Ras for antifungal immunity.
Mycosis Fungoides
Altered expression of Bcl-2, c-Myc, H-Ras, K-Ras, and N-Ras does not influence the course of mycosis fungoides.
Myelodysplastic Syndromes
Multiple point mutation of N-ras and K-ras oncogenes in myelodysplastic syndrome and acute myelogenous leukemia.
Mutations in the ras proto-oncogenes in patients with myelodysplastic syndromes.
Prognostic importance of mutations in the ras proto-oncogenes in de novo acute myeloid leukemia.
ras and human tumors.
Transforming genes and chromosome aberrations in therapy-related leukemia and myelodysplastic syndrome.
Myeloproliferative Disorders
Conditional expression of oncogenic K-ras from its endogenous promoter induces a myeloproliferative disease.
Nf1 deficiency co-operates with oncogenic K-RAS to induce acute myeloid leukemia in mice.
The human GFI136N variant induces epigenetic changes at the Hoxa9 locus and accelerates K-RAS driven myeloproliferative disorder in mice.
Myocardial Infarction
A Functional Relevance of the Anaphylatoxin Receptor C3aR for Platelet Function and Arterial Thrombus Formation Marks an Intersection Point Between Innate Immunity and Thrombosis.
CREG ameliorates the phenotypic switching of cardiac fibroblasts after myocardial infarction via modulation of CDC42.
Expression and Activity of the Small RhoGTPase Cdc42 in Blood Cells of Older Adults Are Associated With Age and Cardiovascular Disease.
Interaction of small G protein signaling modulator 3 with connexin 43 contributes to myocardial infarction in rat hearts.
Rab27a deletion impairs the therapeutic potential of endothelial progenitor cells for myocardial infarction.
Small G protein signaling modulator 3 (SGSM3) knockdown attenuates apoptosis and cardiogenic differentiation in rat mesenchymal stem cells exposed to hypoxia.
[Establishment of a novel therapeutic strategy for heart failure based on the mechanism underlying maintenance of redox homeostasis by reactive sulfur species].
Myocarditis
Common pathways for primary hypertrophic and dilated cardiomyopathy.
Overexpression of microRNA-133b reduces myocardial injuries in children with viral myocarditis by targeting Rab27B gene.
Myotonic Dystrophy
Activation of LIM kinases by myotonic dystrophy kinase-related Cdc42-binding kinase alpha.
Cdc42 antagonizes inductive action of cAMP on cell shape, via effects of the myotonic dystrophy kinase-related Cdc42-binding kinase (MRCK) on myosin light chain phosphorylation.
Characterization of the Interaction of Phorbol Esters with the C1 Domain of MRCK (Myotonic Dystrophy Kinase-related Cdc42 Binding Kinase) {alpha}/{beta}
DOCK8 Protein Regulates Macrophage Migration through Cdc42 Protein Activation and LRAP35a Protein Interaction.
Evidence for a role of MRCK in mediating HeLa cell elongation induced by the C1 domain ligand HMI-1a3.
Expression of the human myotonic dystrophy kinase-related Cdc42-binding kinase gamma is regulated by promoter DNA methylation and Sp1 binding.
Myotonic dystrophy CTG expansion affects synaptic vesicle proteins, neurotransmission and mouse behaviour.
Myotonic dystrophy kinase-related Cdc42-binding kinase acts as a Cdc42 effector in promoting cytoskeletal reorganization.
Myotonic dystrophy kinase-related Cdc42-binding kinases (MRCK), the ROCK-like effectors of Cdc42 and Rac1.
Phosphorylation of a novel myosin binding subunit of protein phosphatase 1 reveals a conserved mechanism in the regulation of actin cytoskeleton.
Phosphorylation of ERM proteins at filopodia induced by Cdc42.
Regulation of microtubules by Rho GTPases in migrating cells.
Targeting Rho GTPase Signaling Networks in Cancer.
The CDC42 effector protein MRCK? autophosphorylates on Threonine 1108.
The myotonic dystrophy kinase-related Cdc42-binding kinase is involved in the regulation of neurite outgrowth in PC12 cells.
Myxoma
Heart myxoma develops oncogenic and metastatic phenotype.
Ras oncogenes and p53 tumor suppressor gene analysis in cardiac myxomas.
Nasopharyngeal Carcinoma
Down-regulation of miRNA-204 by LMP-1 enhances CDC42 activity and facilitates invasion of EBV-associated nasopharyngeal carcinoma cells.
Epstein-Barr virus-encoded LMP1 interacts with FGD4 to activate Cdc42 and thereby promote migration of nasopharyngeal carcinoma cells.
Knockdown Rab11-FIP2 inhibits migration and invasion of nasopharyngeal carcinoma via suppressing Rho GTPase signaling.
Methylation associated inactivation of RASSF1A and its synergistic effect with activated K-Ras in nasopharyngeal carcinoma.
MicroRNA?342?3p suppresses proliferation and invasion of nasopharyngeal carcinoma cells by directly targeting Cdc42.
miR-1, regulated by LMP1, suppresses tumour growth and metastasis by targeting K-ras in nasopharyngeal carcinoma.
Nuclear Klf4 accumulation is associated with cetuximab drug-resistance and predicts poor prognosis of nasopharyngeal carcinoma.
One-dimensional microfluidic beads array for multiple mRNAs expression detection.
RAB37 Hypermethylation Regulates Metastasis and Resistance to Docetaxel-Based Induction Chemotherapy in Nasopharyngeal Carcinoma.
The prognostic impact of RAP2A expression in patients with early and locoregionally advanced nasopharyngeal carcinoma in an endemic area.
[Effects of silencing H-ras gene by RNA interference on cetuximab-sensitivity of cetuximab-resistant human nasopharyngeal carcinoma cells].
Nasopharyngeal Neoplasms
MiR-20a-5p promotes radio-resistance by targeting Rab27B in nasopharyngeal cancer cells.
Neoplasm Metastasis
?-Adrenergic receptors suppress Rap1B prenylation and promote the metastatic phenotype in breast cancer cells.
?-Catenin activates Rho GTPase, promotes lymphangiogenesis and growth of tumor metastases.
?Np63? suppresses cells invasion by downregulating PKC?/Rac1 signaling through miR-320a.
A New Strategy to Control and Eradicate "Undruggable" Oncogenic K-RAS-Driven Pancreatic Cancer: Molecular Insights and Core Principles Learned from Developmental and Evolutionary Biology.
A non-secretory form of FAM3B promotes invasion and metastasis of human colon cancer cells by upregulating Slug expression.
A polysaccharide from Pinellia ternata inhibits cell proliferation and metastasis in human cholangiocarcinoma cells by targeting of Cdc42 and 67kDa Laminin Receptor (LR).
A Targeted Quantitative Proteomic Approach Assesses the Reprogramming of Small GTPases during Melanoma Metastasis.
Aberrant overexpression of the Rgl2 Ral small GTPase-specific guanine nucleotide exchange factor promotes pancreatic cancer growth through Ral-dependent and Ral-independent mechanisms.
Ablation of p120-catenin enhances invasion and metastasis of human lung cancer cells.
Abnormal expression of Rap2A as a prognostic marker for human breast cancer.
Abrogation of RAB27A expression transiently affects melanoma cell proliferation.
Activated K-ras and INK4a/Arf deficiency cooperate during the development of pancreatic cancer by activation of Notch and NF-?B signaling pathways.
Activated Vav2 modulates cellular invasion through Rac1 and Cdc42 in oral squamous cell carcinoma.
Activation of STAT transcription factors by the Rho-family GTPases.
Adenocarcinoma of the pancreas: detection of occult metastases in regional lymph nodes by a polymerase chain reaction-based assay.
ADP-ribosylation factor 6 regulates tumorigenic and invasive properties in vivo.
AFAP1-AS1, a long noncoding RNA upregulated in lung cancer and promotes invasion and metastasis.
Allele-specific detection of K-ras oncogene expression in human non-small-cell lung carcinomas.
Alterations in metastatic properties of hepatocellular carcinoma cell following H-ras oncogene transfection.
Alterations of oncogenes, tumor suppressor genes and growth factors in hepatocellular carcinoma: with relation to tumor size and invasiveness.
An oncogene-tumor suppressor cascade drives metastatic prostate cancer by coordinately activating Ras and nuclear factor-kappaB.
Analysis of gp74 expression by transformed rat fibroblasts from experimental pulmonary metastases following specific ricin A-chain immunotoxin therapy.
Analysis of K-ras, N-ras, H-ras, and p53 in lung neuroendocrine neoplasms.
Analysis of microsatellite instability, K-ras gene mutation and p53 protein overexpression in intrahepatic cholangiocarcinoma.
Analysis of N- and K-ras mutations in the distinctive tumor progression phases of melanoma.
Analysis of the expression and potential molecular mechanism of interleukin-1 receptor antagonist (IL1RN) in papillary thyroid cancer via bioinformatics methods.
Angiogenesis and p53 and H-ras mutations in pancreatic ductal adenocarcinoma.
Anti-metastasis effects of gallic acid on gastric cancer cells involves inhibition of NF-kappaB activity and downregulation of PI3K/AKT/small GTPase signals.
APC, K-ras, and p53 gene mutations in colorectal cancer patients: correlation to clinicopathologic features and postoperative surveillance.
Application of clonal analysis. Differential diagnosis for synchronous primary ovarian and endometrial cancers and metastatic cancer.
Applying Antibodies Inside Cells: Principles and Recent Advances in Neurobiology, Virology and Oncology.
Artemisinin inhibits in vitro and in vivo invasion and metastasis of human hepatocellular carcinoma cells.
Assessment of K-ras, Smad4 and p53 gene alterations in colorectal metastases and their role in the metastatic process.
Association of K-ras mutations with liver metastases from colorectal carcinoma.
Association of matrilysin mRNA expression with K-ras mutations and progression in pancreatic ductal adenocarcinomas.
beta-Catenin and ras oncogenes detect most human colorectal cancer.
Bif-1 promotes tumor cell migration and metastasis via Cdc42 expression and activity.
Bioinformatic Prediction of Signaling Pathways for Apurinic/Apyrimidinic Endodeoxyribonuclease 1 (APEX1) and Its Role in Cholangiocarcinoma Cells.
Blockage of transferred exosome-shuttled miR-494 inhibits melanoma growth and metastasis.
Bmi-1 promotes invasion and metastasis, and its elevated expression is correlated with an advanced stage of breast cancer.
BMI1 cooperates with H-RAS to induce an aggressive breast cancer phenotype with brain metastases.
BNIPL-2 promotes the invasion and metastasis of human hepatocellular carcinoma cells.
BRCA1, C-erbB-2, and H-ras gene expressions in young women with breast cancer. An immunohistochemical study.
Breaking up is hard to do: RalA, mitochondrial fission and cancer.
Bronchioloalveolar adenocarcinoma of lung: monoclonal origin for multifocal disease.
Can K-ras codon 12 mutations be used to distinguish benign bile duct proliferations from metastases in the liver? A molecular analysis of 101 liver lesions from 93 patients.
CD47 Promotes Tumor Invasion and Metastasis in Non-small Cell Lung Cancer.
Cdc42 in oncogenic transformation, invasion, and tumorigenesis.
Cdc42 overexpression induces hyperbranching in the developing mammary gland by enhancing cell migration.
Cdc42 promotes transendothelial migration of cancer cells through ?1 integrin.
Cdc42 subcellular relocation in response to VEGF/NRP1 engagement is associated with the poor prognosis of colorectal cancer.
Cdc42: A Novel Regulator of Insulin Secretion and Diabetes-Associated Diseases.
Cell proliferation and drug resistance in hepatocellular carcinoma are modulated by Rho GTPase signals.
Cell-to-cell contact-mediated regulation of tumor behavior in the tumor microenvironment.
Cells lay their own tracks - optogenetic Cdc42 activation stimulates fibronectin deposition supporting directed migration.
Cellular protoonocogenes are infrequently amplified in untreated non-small cell lung cancer.
Cetuximab for the first-line treatment of metastatic colorectal cancer.
Characterization and effects of miR-21 expression in esophageal cancer.
Characterization of a Dual Rac/Cdc42 Inhibitor MBQ-167 in Metastatic Cancer.
Characterization of EHop-016, a novel small molecule inhibitor of Rac GTPase.
CHD1L promotes hepatocellular carcinoma progression and metastasis in mice and is associated with these processes in human patients.
Clinical significance of K-ras and c-erbB-2 mutations in pancreatic adenocarcinoma and chronic pancreatitis.
Clinical significance of RacGAP1 expression at the invasive front of gastric cancer.
Clinical value of bile for the detection of mutant K-ras from colorectal liver metastases.
Clinicopathological pattern and Annexin A2 and Cdc42 status in patients presenting with differentiation and lymphnode metastasis of esophageal squamous cell carcinomas.
Clonal origin of multiple lung cancers: K-ras and p53 mutations determined by nonradioisotopic single-strand conformation polymorphism analysis.
Co-mutation of p53, K-ras genes and accumulation of p53 protein and its correlation to clinicopathological features in rectal cancer.
Combining clinicopathological predictors and molecular biomarkers in the oncogenic K-RAS/Ki67/HIF-1? pathway to predict survival in resectable pancreatic cancer.
Comparison of EGFR and K-RAS gene status between primary tumours and corresponding metastases in NSCLC.
Comparison of K-ras gene mutations in tumour and sputum DNA of patients with lung cancer.
Comparison of K-ras mutations in lung, colorectal and gastric cancer.
Comparison of oncogene mutation detection and telomerase activity for the molecular staging of non-small cell lung cancer.
Comprehensive genomic analyses of a metastatic colon cancer to the lung by whole exome sequencing and gene expression analysis.
Control of colorectal metastasis formation by K-Ras.
Control of Rho GTPase function by BAR-domains.
Conversion to complete resection with mFOLFOX6 with bevacizumab or cetuximab based on K-ras status for unresectable colorectal liver metastasis (BECK study).
Conversion to complete resection with mFOLFOX6 with bevacizumab or cetuximab based on K-RAS status for unresectable colorectal liver metastasis (BECK study): Long-term results of survival.
Coping with strong translational noncrystallographic symmetry and extreme anisotropy in molecular replacement with Phaser: human Rab27a.
Correlation Between RAB27B and p53 Expression and Overall Survival in Pancreatic Cancer.
Correlation of COX-2 and K-ras expression to clinical outcome in gastric cancer.
Cost-effectiveness of targeted therapy with cetuximab in patients with K-ras wild-type colorectal cancer presenting with initially unresectable metastases limited to the liver in a German setting.
Crystallographic characterization of the membrane-targeting domains of the Rac-specific guanine nucleotide-exchange factors Tiam1 and Tiam2.
CtBP-a targetable dependency for tumor-initiating cell activity and metastasis in pancreatic adenocarcinoma.
CtBP2 Promotes Human Cancer Cell Migration by Transcriptional Activation of Tiam1.
Cucurbitacin I Inhibits Rac1 Activation in Breast Cancer Cells by a Ros-Mediated Mechanism and Independently of Jak2 and P-Rex1.
Curative resection of hilar cholangiocarcinoma in a 25-year-old woman: report of a case.
Cyclooxygenase-2 overexpression is a marker of poor prognosis in stage I non-small cell lung cancer.
DAB2IP Plays Important Clinical Significance and Correlates With Immune Infiltration in Renal Cell Carcinoma.
Decreased expression of Rab27A and Rab27B correlates with metastasis and poor prognosis in colorectal cancer.
Degradation of Tiam1 by casein kinase 1 and the SCF?TrCP ubiquitin ligase controls the duration of mTOR-S6K signaling.
Deleted in liver cancer 1 (DLC1) negatively regulates Rho/ROCK/MLC pathway in hepatocellular carcinoma.
Deleted in Liver Cancer-1 (DLC1): An Emerging Metastasis Suppressor Gene.
Deregulation of SLIT2-Mediated Cdc42 Activity Is Associated with Esophageal Cancer Metastasis and Poor Prognosis.
Detection of activating mutations in the ras family genes in cytological specimens from lung-tumors.
Detection of isolated tumor cells by polymerase chain reaction-restriction fragment length polymorphism for K-ras mutations in tissue samples of 199 colorectal cancer patients.
Detection of K-ras gene mutations in plasma DNA of patients with pancreatic adenocarcinoma: correlation with clinicopathological features.
Detection of K-ras mutations in the plasma DNA of pancreatic cancer patients.
Detection of K-ras point mutations in mesenteric venous blood from colorectal cancer patients by enriched polymerase chain reaction and single-strand conformation polymorphism analysis.
Detection of multiple hepatic micrometastases in pancreatic adenocarcinoma with a solitary liver metastasis by direct sequencing of the K-ras gene: a case report.
Detection of mutant K-ras DNA in plasma or serum of patients with colorectal cancer.
Detection of mutated K12-ras in histologically negative lymph nodes as an indicator of poor prognosis in stage II colorectal cancer.
Detection of occult metastases in sentinel lymph nodes from colon cancer patients by K-ras mutation peptide nucleic acid clamp PCR.
Determination of microsatellite instability, p53 and K-RAS mutations in hepatic metastases from patients with colorectal cancer: relationship with response to 5-fluorouracil and survival.
Differing deregulation of EGFR and downstream proteins in primary colorectal cancer and related metastatic sites may be clinically relevant.
Discordance of Mutation Statuses of Epidermal Growth Factor Receptor and K-ras between Primary Adenocarcinoma of Lung and Brain Metastasis.
Discrepancies between the K-ras mutational status of primary colorectal cancers and corresponding liver metastases are found in codon 13.
Dissected peripancreatic tissue margin is a critical prognostic factor and is associated with a K-ras gene mutation in pancreatic ductal adenocarcinoma.
Disseminated colorectal tumor cells in organs prone to metastasis detected by new double enriched nested-PCR in comparison with recognized assays.
Dissociation mechanism of GDP from Cdc42 via DOCK9 revealed by molecular dynamics simulations.
DNA alterations of microsatellite DNA, p53, APC and K-ras in Chinese colorectal cancer patients.
Donor polymorphisms of Rap1A rs494453 contribute to a higher risk of hepatocellular carcinoma recurrence following liver transplantation.
Down-regulation of miRNA-204 by LMP-1 enhances CDC42 activity and facilitates invasion of EBV-associated nasopharyngeal carcinoma cells.
Downregulation of Rab23 inhibits proliferation, invasion, and metastasis of human ovarian cancer.
Downregulation of RECK by promoter methylation correlates with lymph node metastasis in non-small cell lung cancer.
Dysregulation of Rab37-Mediated Cross-talk between Cancer Cells and Endothelial Cells via Thrombospondin-1 Promotes Tumor Neovasculature and Metastasis.
Dysregulation of Rho GTPases in Human Cancers.
Early detection of leptomeningeal metastasis by PCR examination of tumor-derived K-ras DNA in cerebrospinal fluid.
Effect of microRNA-206 on cytoskeleton remodelling by downregulating Cdc42 in MDA-MB-231 cells.
Effect of the secretory small GTPase Rab27B on breast cancer growth, invasion, and metastasis.
Effects of CDC42 on the proliferation and invasion of gastric cancer cells.
Efficacy of an angiogenesis inhibitor, TNP-470, in xenotransplanted human colorectal cancer with high metastatic potential.
Enhanced Expression of Rab27A Gene by Breast Cancer Cells Promoting Invasiveness and the Metastasis Potential by Secretion of Insulin-Like Growth Factor-II.
Enhanced spontaneous metastasis of mouse carcinoma cells transfected with an activated c-Ha-ras-1 gene.
Enhancement of migration and invasion of hepatoma cells via a Rho GTPase signaling pathway.
Epidermal Growth Factor Receptor Mutation and Pathologic-Radiologic Correlation Between Multiple Lung Nodules with Ground-Glass Opacity Differentiates Multicentric Origin from Intrapulmonary Spread.
ERM/Rho protein expression in ductal breast cancer: a 15 year follow-up.
Evolution of intratumoral genetic heterogeneity during colorectal cancer progression.
Exercise modulates redox-sensitive small GTPase activity in the brain microvasculature in a model of brain metastasis formation.
Expression analysis of Cdc42 in lung cancer and modulation of its expression by curcumin in lung cancer cell lines.
Expression of chemokine receptor CCR5 correlates with the presence of hepatic molecular metastases in K-ras positive human colorectal cancer.
Expression of H-ras correlates with metastatic potential: evidence for direct regulation of the metastatic phenotype in 10T1/2 and NIH 3T3 cells.
Expression of P21-activated kinase 1 and cell division control protein 42 homolog correlates with clinicopathological features and prognosis in cervical carcinoma.
Expression of RAP1B is associated with poor prognosis and promotes an aggressive phenotype in gastric cancer.
Expression of Tiam-1 in the developing brain suggests a role for the Tiam-1-Rac signaling pathway in cell migration and neurite outgrowth.
Extended staging results from the detection of isolated tumor cells in the liver of colorectal cancer patients.
Factors affecting prognosis in metastatic colorectal cancer patients.
Fast simultaneous detection of K-RAS mutations in colorectal cancer.
Fasudil suppresses fibrosarcoma growth by stimulating secretion of the chemokine CXCL14/BRAK.
Friend leukemia virus integration 1 activates the Rho GTPase pathway and is associated with metastasis in breast cancer.
Function, Significance, and Regulation of Rap1b in Malignancy.
Functionalized Graphene@Gold Nanostar/Lipid for Pancreatic Cancer Gene and Photothermal Synergistic Therapy under Photoacoustic/Photothermal Imaging Dual-Modal Guidance.
Gain of miR-151 on chromosome 8q24.3 facilitates tumour cell migration and spreading through downregulating RhoGDIA.
Genetic Alterations of K-ras, p53, c-erbB-2, and DPC4 in Pancreatic Ductal Adenocarcinoma and Their Correlation With Patient Survival.
Genetic and epigenetic changes in primary metastatic and nonmetastatic colorectal cancer.
Genetic and histological assessment of surgical margins in resected liver metastases from colorectal carcinoma: minimum surgical margins for successful resection.
Genetic detection of colorectal cancer cells in circulation and lymph nodes.
Genetic diagnosis identifies occult lymph node metastases undetectable by the histopathological method.
Genetic diagnosis of lymph-node metastasis in colorectal cancer.
Genetic markers of survival and liver recurrence after resection of liver metastases from colorectal cancer.
Genome-wide analysis of chromosomal alterations in patients with esophageal squamous cell carcinoma exposed to tobacco and betel quid from high-risk area in India.
Genomic amplicons target vesicle recycling in breast cancer.
Genomic analysis of metastasis reveals an essential role for RhoC.
Geranylgeranyltransferase I promotes human glioma cell growth through Rac1 membrane association and activation.
Glucocorticoids mediate induction of microRNA-708 to suppress ovarian cancer metastasis through targeting Rap1B.
Glutaminase 2 is a novel negative regulator of small GTPase Rac1 and mediates p53 function in suppressing metastasis.
Growth factor-mediated altered expression and regulation of S-adenosylmethionine decarboxylase in a H-ras transformed cell line capable of malignant progression.
H-ras Consensus Sequence and Mutations in Primary Hepatocellular Carcinomas of Lemurs and Lorises.
H-ras mutations in human pituitary carcinoma metastases.
HCC-derived exosomes elicit HCC progression and recurrence by epithelial-mesenchymal transition through MAPK/ERK signalling pathway.
Hepatic disseminated tumor cells in colorectal cancer UICC stage 4 patients: prognostic implications.
Heterogeneous distribution of K-ras mutations in primary colon carcinomas: implications for EGFR-directed therapy.
High expression of Rap2A is associated with poor prognosis of patients with hepatocellular carcinoma.
High expression of small GTPase Rab3D promotes cancer progression and metastasis.
High frequency of K-ras mutations in normal appearing lung tissues and sputum of patients with lung cancer.
High Rab27A expression indicates favorable prognosis in CRC.
Histone deacetylase 1 represses the small GTPase RhoB expression in human nonsmall lung carcinoma cell line.
Homologous orthotopic implantation models of pancreatic ductal cancer in Syrian golden hamsters: which is better for metastasis research--cell implantation or tissue implantation?
Human papillomavirus and mutated H-ras oncogene in cervical carcinomas and pathological negative pelvic lymph nodes: a retrospective follow-up.
Human ZNF312b promotes the progression of gastric cancer by transcriptional activation of the K-ras gene.
Hypermethylation of SHISA3 Promotes Nasopharyngeal Carcinoma Metastasis by Reducing SGSM1 Stability.
Identification of mRNA and non-coding RNA hubs using network analysis in organ tropism regulated triple negative breast cancer metastasis.
Identification of the potential biomarkers for the metastasis of rectal adenocarcinoma.
Identifying Cancer-Relevant Mutations in the DLC START Domain Using Evolutionary and Structure-Function Analyses.
IL-4/IL-13 Stimulated Macrophages Enhance Breast Cancer Invasion Via Rho-GTPase Regulation of Synergistic VEGF/CCL-18 Signaling.
Immunohistochemical evaluation of P21ras and P53 proteins expression in human non-small-cell lung cancers.
Immunoperoxidase staining for cytokeratins 8 and 18 is very sensitive for detection of occult node metastasis of colorectal cancer: a comparison with genetic analysis of K-ras.
In-depth NMR characterization of Rab4a structure, nucleotide exchange and hydrolysis kinetics reveals an atypical GTPase profile.
Inactivation of Rab23 inhibits the invasion and motility of pancreatic duct adenocarcinoma.
Inactivation of Rab27B-dependent signaling pathway by calycosin inhibits migration and invasion of ER-negative breast cancer cells.
Incidence and possible clinical significance of K-ras oncogene activation in adenocarcinoma of the human lung.
Increased expression of annexin A1 is correlated with K-ras mutation in colorectal cancer.
Increased Rac1 activity and Pak1 overexpression are associated with lymphovascular invasion and lymph node metastasis of upper urinary tract cancer.
Inhibiting the phosphatidylinositide 3-kinase pathway blocks radiation-induced metastasis associated with Rho-GTPase and Hypoxia-inducible factor-1 activity.
Inhibition effects of Yuxiao San combined with cisplatin on transplanted tumor growths via upregulation of nm-23 and downregulation of K-ras in Lewis lung cancer mice.
Inhibition of AKT1 signaling promotes invasion and metastasis of non-small cell lung cancer cells with K-RAS or EGFR mutations.
Inhibition of cancer cell invasion by new ((3,4-dihydroxy benzylidene)hydrazinyl)pyridine-3-sulfonamide analogs.
Inhibition of CDC42 reduces macrophage recruitment and suppresses lung tumorigenesis in vivo.
Inhibition of cell proliferation and metastasis of human hepatocellular carcinoma by miR-137 is regulated by CDC42.
Inhibition of gastric cancer cell growth and invasion through siRNA-mediated knockdown of guanine nucleotide exchange factor Vav3.
Inhibition of Rac1 reverses enzalutamide resistance in castration-resistant prostate cancer.
Insights into oncogenic mutations of plexin-B1 based on the solution structure of the Rho GTPase binding domain.
Insulin like growth factor-1 selectively regulates the expression of matrix metalloproteinase-2 in malignant H-ras transformed cells.
Integrin ?9 Suppresses Hepatocellular Carcinoma Metastasis by Rho GTPase Signaling.
Interaction between Peptidyl-prolyl Cis-trans Isomerase NIMA-interacting 1 and GTP-H-Ras: Implications for Aggressiveness of Human Mammary Epithelial Cells and Drug Resistance.
K-ras and p53 mutations in the pathogenesis of classical and goblet cell carcinoids of the appendix.
K-ras gene point mutation: a stable tumor marker in non-small cell lung carcinoma.
K-ras genetic mutation and influencing factor analysis for Han and Uygur nationality colorectal cancer patients.
K-ras mutation in Greek patients with poorly and moderately differenciated tumours of the lower intestinal tract.
K-ras mutation is an early event in pancreatic duct carcinogenesis in the Syrian golden hamster.
K-ras Mutation is Strongly Associated with Perineural Invasion and Represents an Independent Prognostic Factor of Intrahepatic Cholangiocarcinoma after Hepatectomy.
K-RAS mutation profile in Puerto Rican patients with colorectal cancer: trends from April 2009 to January 2011.
K-ras mutational status predicts poor prognosis in unresectable pancreatic cancer.
K-ras mutations and prognosis in large-bowel carcinomas.
K-Ras mutations and treatment outcome in colorectal cancer patients receiving exclusive fluoropyrimidine therapy.
K-ras mutations are correlated to lymph node metastasis and tumor stage, but not to the growth pattern of colon carcinoma.
K-ras mutations in colorectal cancer: a practice changing discovery.
K-ras mutations in DNA extracted from the plasma of patients with pancreatic carcinoma: diagnostic utility and prognostic significance.
K-ras oncogene mutation in cancer and precancerous lesions of the gallbladder.
K-ras point mutations in endometrial carcinoma: effect on outcome is dependent on age of patient.
K-ras point mutations in human colorectal carcinomas: relation to aneuploidy and metastasis.
K-ras status does not predict successful hepatic resection of colorectal cancer metastasis.
Keratin 20 is a specific marker of submicroscopic lymph node metastases in colorectal cancer: validation by K-RAS mutations.
Kinase-dependent and -independent roles of EphA2 in the regulation of prostate cancer invasion and metastasis.
Knockdown of Arf6 increases drug sensitivity and inhibits proliferation, migration and invasion in gastric cancer SGC-7901 cells.
Knockdown of contactin-1 expression suppresses invasion and metastasis of lung adenocarcinoma.
KY1022, a small molecule destabilizing Ras via targeting the Wnt/?-catenin pathway, inhibits development of metastatic colorectal cancer.
Lentivirus-mediated carboxyl-terminal modulator protein gene transfection via aerosol in lungs of K-ras null mice.
Let-7c functions as a metastasis suppressor by targeting MMP11 and PBX3 in colorectal cancer.
Long non-coding RNA NEAT1 promotes tumor development and metastasis through targeting RAB9A in malignant melanoma.
Loss of a reporter gene for green fluorescent protein during tumor progression suggests the recruitment of host cells in rats with experimentally induced colon cancer.
Loss of heterozygosity and microsatellite instability of the h-ras gene in cancer of the head and neck.
Loss of RAB1B promotes triple-negative breast cancer metastasis by activating TGF-?/SMAD signaling.
Loss of the novel tumour suppressor and polarity gene Trim62 (Dear1) synergizes with oncogenic Ras in invasive lung cancer.
Loss of transforming growth factor-beta type II receptor promotes metastatic head-and-neck squamous cell carcinoma.
Malignant transformation of an epithelial cell by v-Src via tv-a-mediated retroviral infection: a new cell model for studying carcinogenesis.
Mechanism of WASP and WAVE family proteins in the progression of prostate cancer.
Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET.
Metastasis is driven by sequential elevation of H-ras and Smad2 levels.
Metastasis of benign tumor cells in tuberous sclerosis complex.
Microarray-based copy number analysis of neurofibromatosis type-1 (NF1)-associated malignant peripheral nerve sheath tumors reveals a role for Rho-GTPase pathway genes in NF1 tumorigenesis.
MicroRNA Regulation of the Small Rho GTPase Regulators-Complexities and Opportunities in Targeting Cancer Metastasis.
MicroRNA-105 is involved in TNF-?-related tumor microenvironment enhanced colorectal cancer progression.
MicroRNA-151 and its hosting gene FAK (focal adhesion kinase) regulate tumor cell migration and spreading of hepatocellular carcinoma.
MicroRNA-195 suppresses angiogenesis and metastasis of hepatocellular carcinoma by inhibiting the expression of VEGF, VAV2 and CDC42.
MicroRNA-206 suppresses gastric cancer cell growth and metastasis.
MicroRNA-30b-5p functions as a metastasis suppressor in colorectal cancer by targeting Rap1b.
MicroRNA-548j functions as a metastasis promoter in human breast cancer by targeting Tensin1.
MicroRNA-665 suppressed the invasion and metastasis of osteosarcoma by directly inhibiting RAB23.
MicroRNA?342?3p suppresses proliferation and invasion of nasopharyngeal carcinoma cells by directly targeting Cdc42.
MicroRNAs targeting mutant K-ras by electrotransfer inhibit human colorectal adenocarcinoma cell growth in vitro and in vivo.
Microvessel density, cyclo-oxygenase 2 expression, K-ras mutation and p53 overexpression in colonic cancer.
Minireview: Mouse Models of Rho GTPase Function in Mammary Gland Development, Tumorigenesis, and Metastasis.
miR-1, regulated by LMP1, suppresses tumour growth and metastasis by targeting K-ras in nasopharyngeal carcinoma.
miR-143 inhibits the metastasis of pancreatic cancer and an associated signaling pathway.
MiR-193a-3p and miR-193a-5p suppress the metastasis of human osteosarcoma cells by down-regulating Rab27B and SRR, respectively.
MiR-196a binding-site SNP regulates RAP1A expression contributing to esophageal squamous cell carcinoma risk and metastasis.
MiR-203 down-regulates Rap1A and suppresses cell proliferation, adhesion and invasion in prostate cancer.
miR-211 regulates the expression of RRM2 in tumoral metastasis and recurrence in colorectal cancer patients with a k-ras gene mutation.
MiR-384 inhibits human colorectal cancer metastasis by targeting KRAS and CDC42.
MiR-429 regulates the metastasis and EMT of HCC cells through targeting RAB23.
miR-431 Promotes Metastasis of Pancreatic Neuroendocrine Tumors by Targeting DAB2 Interacting Protein, a Ras GTPase Activating Protein Tumor Suppressor.
MiR-622 inhibited colorectal cancer occurrence and metastasis by suppressing K-Ras.
Mir20a/106a-WTX axis regulates RhoGDIa/CDC42 signaling and colon cancer progression.
miR?367?3p downregulates Rab23 expression and inhibits Hedgehog signaling resulting in the inhibition of the proliferation, migration, and invasion of prostate cancer cells.
miRNA-143 replacement therapy harnesses the proliferation and migration of colorectal cancer cells in vitro.
MKL1 Mediates TGF-? Induced RhoJ Transcription to Promote Breast Cancer Cell Migration and Invasion.
Modified mismatch polymerase chain reaction-restriction fragment length polymorphism detected mutations in codon 12 and 13 of exon 2 of K-
Modulation of apoptosis, tumorigenesity and metastatic potential with antisense H-ras oligodeoxynucleotides in a high metastatic tumor model of hepatoma: LCI-D20.
Modulation of E-cadherin expression by K-Ras; involvement of DNA methyltransferase-3b.
Modulation of tumor induction and progression of oncogenic K-ras-positive tumors in the presence of TGF- b1 haploinsufficiency.
Molecular assessment of lymph nodes in patients with resected stage I non-small cell lung cancer: preliminary results of a prospective study.
Molecular detection of clinical colorectal cancer metastasis: how should multiple markers be put to use?
Molecular detection of neoplastic cells in lymph nodes of metastatic colorectal cancer patients predicts recurrence.
Molecular staging of colorectal cancer: K-ras mutation analysis of lymph nodes upstages Dukes B patients.
Mutant K-RAS Promotes Invasion and Metastasis in Pancreatic Cancer Through GTPase Signaling Pathways.
Mutation status of genes encoding RhoA, Rac1, and Cdc42 GTPases in a panel of invasive human colorectal and breast tumors.
Mutational activation of the K-ras oncogene. A possible pathogenetic factor in adenocarcinoma of the lung.
Mutations and amplification of oncogenes in endometrial cancer.
Mutations in epidermal growth factor receptor and K-ras in Chinese patients with colorectal cancer.
MYC is a metastasis gene for non-small-cell lung cancer.
Myosin-interacting guanine exchange factor (MyoGEF) regulates the invasion activity of MDA-MB-231 breast cancer cells through activation of RhoA and RhoC.
Natural killer cell regulation of implantation and early lung growth of H-ras-transformed 10T1/2 fibroblasts in mice.
Nm23-H1 modulates the activity of the guanine exchange factor Dbl-1.
No back seat for a progression event-K-RAS as a therapeutic target in CRC.
Novel Regulation of Integrin Trafficking by Rab11-FIP5 in Aggressive Prostate Cancer.
Novel synthetic oleanane triterpenoid AMR-MeOAc inhibits K-Ras through ERK, Akt and survivin in pancreatic cancer cells.
O-GlcNAcylation on Rab3A attenuates its effects on mitochondrial oxidative phosphorylation and metastasis in hepatocellular carcinoma.
O-linked GlcNAcylation elevated by HPV E6 mediates viral oncogenesis.
Oncogenes and metastatic progression.
Oncogenic K-Ras and loss of Smad4 mediate invasion by activating an EGFR/NF-?B Axis that induces expression of MMP9 and uPA in human pancreas progenitor cells.
Oncogenic K-Ras Turns Death Receptors Into Metastasis-Promoting Receptors in Human and Mouse Colorectal Cancer Cells.
Oncosuppressor methylation: A possible key role in colon metastatic progression.
Orthotopic xenografts of human pancreatic carcinomas acquire genetic aberrations during dissemination in nude mice.
Ovarian clear cell carcinomas: RHO GTPases may contribute to explain their singular biologic behavior.
Overexpression and biological function of IQGAP3 in human pancreatic cancer.
Overexpression of MEKK2 is associated with colorectal carcinogenesis.
Overexpression of Rab1B and MMP9 predicts poor survival and good response to chemotherapy in patients with colorectal cancer.
Overexpression of Rab27B is correlated with distant metastasis and poor prognosis in ovarian cancer.
Overexpression of RhoV Promotes the Progression and EGFR-TKI Resistance of Lung Adenocarcinoma.
Overexpression of the secretory small GTPase Rab27B in human breast cancer correlates closely with lymph node metastasis and predicts poor prognosis.
p38{gamma} promotes breast cancer cell motility and metastasis through regulation of RhoC GTPase, cytoskeletal architecture, and a novel leading edge behavior.
p53 and H-ras mutations and microsatellite instability in renal pelvic carcinomas of NON / Shi mice treated with N-butyl-N-(4-hydroxybutyl)-nitrosamine: different genetic alteration from urinary bladder carcinoma.
p8 expression controls pancreatic cancer cell migration, invasion, adhesion and tumorigenesis.
Pamidronate induced anti-proliferative, apoptotic, and anti-migratory effects in hepatocellular carcinoma.
Pancreatic cancer heterogeneity and response to Mek inhibition.
Pathological functions of the small GTPase Arf6 in cancer progression: Tumor angiogenesis and metastasis.
Paving the Rho in cancer metastasis: Rho GTPases and beyond.
Peptide nucleic acid clamp PCR: a novel K-ras mutation detection assay for colorectal cancer micrometastases in lymph nodes.
Phenotype of bone metastases of non-small cell lung cancer: epidermal growth factor receptor expression and K-RAS mutational status.
Phenotypic classification of gastric signet ring cell carcinoma and its relationship with K-ras mutation.
Phosphorylation of Rab-coupling protein by LMTK3 controls Rab14-dependent EphA2 trafficking to promote cell:cell repulsion.
Phosphorylation of Rab37 by protein kinase C alpha inhibits the exocytosis function and metastasis suppression activity of Rab37.
Pleiotropic functions of Rho GTPase signaling: a Trojan horse or Achilles' heel for breast cancer treatment?
Prediction of breast cancer proteins involved in immunotherapy, metastasis, and RNA-binding using molecular descriptors and artificial neural networks.
Presence of ras oncogene mutations and human papillomavirus DNA in human prostate carcinomas.
Pro-metastatic signaling by c-Met through RAC-1 and reactive oxygen species (ROS).
Progesterone and calcitriol reduce invasive potential of endometrial cancer cells by targeting ARF6, NEDD9 and MT1-MMP.
Prognostic factors of colorectal cancer: K-ras mutation, overexpression of the p53 protein, and cell proliferative activity.
Prognostic impact of K-RAS mutational status and primary tumor location in patients undergoing resection for colorectal cancer liver metastases: an update.
Prognostic impact of K-RAS mutational status and primary tumour location in patients undergoing resection for colorectal cancer liver metastases: A METHEPAR analysis (multicentre study in Argentina).
Prognostic role of Rab27A and Rab27B expression in patients with non-small cell lung carcinoma.
Prognostic significance of Rab27 expression in solid cancer: a systematic review and meta-analysis.
Prognostic significance of ras/p21 alterations in human ovarian cancer.
Prognostic value of disseminated colorectal tumor cells in the liver: results of follow-up examinations.
Progress in the therapeutic inhibition of Cdc42 signalling.
Proteogenomic Analysis of Human Colon Carcinoma Cell Lines LIM1215, LIM1899, and LIM2405.
R-Ketorolac Targets Cdc42 and Rac1 and Alters Ovarian Cancer Cell Behaviors Critical for Invasion and Metastasis.
Rab11 collaborates E-cadherin to promote collective cell migration and indicates a poor prognosis in colorectal carcinoma.
RAB18 promotes proliferation and metastasis in hepatocellular carcinoma.
Rab18 Regulates Proliferation, Invasion and Cisplatin Sensitivity Through STAT3 Signaling in Head and Neck Squamous Cell Carcinoma.
RAB23, regulated by miR-92b, promotes the progression of esophageal squamous cell carcinoma.
Rab27a plays a dual role in metastatic propensity of pancreatic cancer.
RAB27A promotes melanoma cell invasion and metastasis via regulation of pro-invasive exosomes.
RAB27A, RAB27B and VPS36 are downregulated in advanced prostate cancer and show functional relevance in prostate cancer cells.
Rab27b Is a Potential Indicator for Lymph Node Metastasis and Unfavorable Prognosis in Lung Adenocarcinoma.
Rab27b is a potential predictor for metastasis and prognosis in colorectal cancer.
RAB37 Hypermethylation Regulates Metastasis and Resistance to Docetaxel-Based Induction Chemotherapy in Nasopharyngeal Carcinoma.
Rab37 in lung cancer mediates exocytosis of soluble ST2 and thus skews macrophages toward tumor-suppressing phenotype.
RAB38 is a potential prognostic factor for tumor recurrence in non-small cell lung cancer.
Rac inhibition as a novel therapeutic strategy for EGFR/HER2 targeted therapy resistant breast cancer.
Rac1 contributes to trastuzumab resistance of breast cancer cells: Rac1 as a potential therapeutic target for the treatment of trastuzumab-resistant breast cancer.
Rac1 targeting suppresses human non-small cell lung adenocarcinoma cancer stem cell activity.
Rac1b negatively regulates TGF-?1-induced cell motility in pancreatic ductal epithelial cells by suppressing Smad signalling.
Rap1A promotes esophageal squamous cell carcinoma metastasis through the AKT signaling pathway.
Rap1A promotes ovarian cancer metastasis via activation of ERK/p38 and notch signaling.
RAP1B, a DVL2 binding protein, activates Wnt/beta-catenin signaling in esophageal squamous cell carcinoma.
Rap2a is a novel target gene of p53 and regulates cancer cell migration and invasion.
Rap2a serves as a potential prognostic indicator of renal cell carcinoma and promotes its migration and invasion through up-regulating p-Akt.
Rap2c as a Novel Biomarker for Predicting Poor Prognosis in Glioma.
ras gene mutations in ethmoid sinus adenocarcinoma: prognostic implications.
RCC2 is a novel p53 target in suppressing metastasis.
Rce1 suppresses invasion and metastasis of hepatocellular carcinoma via epithelial-mesenchymal transition induced by the TGF-?1/H-Ras signaling pathway.
Re. article entitled 'Keratin 20 is a specific marker of submicroscopic lymph node metastases in colorectal cancer: validation by K-RAS mutations'.
Recruitment of Tiam1 to Semaphorin 4D Activates Rac and Enhances Proliferation, Invasion, and Metastasis in Oral Squamous Cell Carcinoma.
Regulating Cdc42 and Its Signaling Pathways in Cancer: Small Molecules and MicroRNA as New Treatment Candidates.
Regulation of CXCR4/AKT-signaling-induced cell invasion and tumor metastasis by RhoA, Rac-1, and Cdc42 in human esophageal cancer.
Regulation of the small GTPase Ran by miR-802 modulates proliferation and metastasis in colorectal cancer cells.
Relevance of Ki-67 antigen expression and K-ras mutation in colorectal liver metastases.
Restoration of mutant K-Ras repressed miR-199b inhibits K-Ras mutant non-small cell lung cancer progression.
Rho family GTPases regulate mammary epithelium cell growth and metastasis through distinguishable pathways.
Rho GDP dissociation inhibitor 2 suppresses metastasis via unconventional regulation of RhoGTPases.
Rho GTPase effector functions in tumor cell invasion and metastasis.
Rho GTPase RhoJ is Associated with Gastric Cancer Progression and Metastasis.
Rho GTPases link cytoskeletal rearrangements and activation processes induced via the tetraspanin CD82 in T lymphocytes.
Rho?associated kinase inhibitor, Y?27632, inhibits the invasion and proliferation of T24 and 5367 bladder cancer cells.
RHOB influences lung adenocarcinoma metastasis and resistance in a host-sensitive manner.
RhoC mediates invasion and migration of CaSki cells through the Rho-associated serine-threonine protein kinase 1 signaling pathway.
RhoC Modulates Cell Junctions and Type I Interferon Response in Aggressive Breast Cancers.
RhoE is frequently downregulated in HCC and suppresses HCC invasion through antagonizing the Rho/ROCK/MYPT pathway.
RhoGTPases and Rho-effectors in hepatocellular carcinoma metastasis: ROCK N'Rho move it.
Rhoj Is a Novel Target for Progression and Invasion of Glioblastoma by Impairing Cytoskeleton Dynamics.
RNA Interference of IQ Motif Containing GTPase-Activating Protein 3 (IQGAP3) Inhibits Cell Proliferation and Invasion in Breast Carcinoma Cells.
RNA-interference-mediated Cdc42 silencing down-regulates phosphorylation of STAT3 and suppresses growth in human bladder-cancer cells.
Rock2 stabilizes ?-catenin to promote tumor invasion and metastasis in colorectal cancer.
Role of ARHGAP24 in ADP Ribosylation Factor 6 (ARF6)-dependent Pseudopod Formation in Human Breast Carcinoma Cells.
Role of retinoids in the prevention and treatment of colorectal cancer.
Role of Rho GTPases in breast cancer.
Role of tumor markers and mutations in cells and pancreatic juice in the diagnosis of pancreatic cancer.
Role of vasodilator-stimulated phosphoprotein in RANKL-differentiated murine macrophage RAW264.7 cells: Modulation of NF-?B, c-Fos and NFATc1 transcription factors.
Roles of Rap1 signaling in tumor cell migration and invasion.
RPEL-family rhoGAPs link Rac/Cdc42 GTP loading to G-actin availability.
Secretory RAB GTPase 3C modulates IL6-STAT3 pathway to promote colon cancer metastasis and is associated with poor prognosis.
Selection for spontaneous metastasis after calcium phosphate-mediated transfer of DNA.
Selective stabilization of multiple promoter G-quadruplex DNA by using 2-phenyl-1H-imidazole-based tanshinone IIA derivatives and their potential suppressing function in the metastatic breast cancer.
Sensitive detection of K-ras mutations augments diagnosis of colorectal cancer metastases in the liver.
Signalling to cancer cell invasion through PAK family kinases.
Silencing Ras-Related C3 Botulinum Toxin Substrate 1 Inhibits Growth and Migration of Hypopharyngeal Squamous Cell Carcinoma via the P38 Mitogen-Activated Protein Kinase Signaling Pathway.
Small G protein signalling modulator 2 (SGSM2) is involved in oestrogen receptor-positive breast cancer metastasis through enhancement of migratory cell adhesion via interaction with E-cadherin.
Small GTPase Rab37 targets tissue inhibitor of metalloproteinase 1 for exocytosis and thus suppresses tumour metastasis.
SNX9 promotes metastasis by enhancing cancer cell invasion via differential regulation of RhoGTPases.
Specific codon 13 K-ras mutations are predictive of clinical outcome in colorectal cancer patients, whereas codon 12 K-ras mutations are associated with mucinous histotype.
Specific cross-talk between epidermal growth factor receptor and integrin alphavbeta5 promotes carcinoma cell invasion and metastasis.
Subgroup Analysis by Liver Metastasis in the FRESCO Trial Comparing Fruquintinib versus Placebo Plus Best Supportive Care in Chinese Patients with Metastatic Colorectal Cancer.
Successful Multidisciplinary Treatment with Secondary Metastatic Liver Resection after Downsizing by Palliative Second-Line Treatment of Colorectal Cancer: A Curative Option.
Suppression of A549 lung cancer cell migration by precursor let-7g microRNA.
Surgical treatment of hepatocellular carcinoma and related basic research with special reference to recurrence and metastasis.
Synthetic 8-hydroxydeoxyguanosine inhibited metastasis of pancreatic cancer through concerted inhibitions of ERM and Rho-GTPase.
Targeting Rac and Cdc42 GEFs in Metastatic Cancer.
Targeting TRAF3IP2, Compared to Rab27, is More Effective in Suppressing the Development and Metastasis of Breast Cancer.
The brain microenvironment negatively regulates miRNA-768-3p to promote K-ras expression and lung cancer metastasis.
The cancer-associated, gain-of-function TP53 variant P152Lp53 activates multiple signaling pathways implicated in tumorigenesis.
The E3-ligase E6AP Represses Breast Cancer Metastasis via Regulation of ECT2-Rho Signaling.
The guanine nucleotide exchange factor Tiam1 affects neuronal morphology; opposing roles for the small GTPases Rac and Rho.
The Jumonji Domain-Containing Histone Demethylase Homolog 1D/lysine Demethylase 7A (JHDM1D/KDM7A) Is an Epigenetic Activator of RHOJ Transcription in Breast Cancer Cells.
The microRNA-367 Inhibits the Invasion and Metastasis of Gastric Cancer by Directly Repressing Rab23.
The MLK-related Kinase (MRK) Is a Novel RhoC Effector That Mediates Lysophosphatidic Acid (LPA)-stimulated Tumor Cell Invasion.
The noncoding RNA HOXD-AS1 is a critical regulator of the metastasis and apoptosis phenotype in human hepatocellular carcinoma.
The Presence of Mutations in the K-RAS Gene Does Not Affect Survival after Resection of Pulmonary Metastases from Colorectal Cancer.
The prognostic impact of RAP2A expression in patients with early and locoregionally advanced nasopharyngeal carcinoma in an endemic area.
The prognostic significance of p63 cytoplasmic expression in colorectal cancer. An immunohistochemical study.
The R-Enantiomer of Ketorolac Delays Mammary Tumor Development in Mouse Mammary Tumor Virus-Polyoma Middle T Antigen (MMTV-PyMT) Mice.
The relationship between microvessel count and the expression of vascular endothelial growth factor, p53, and K-ras in non-small cell lung cancer.
The Rho GTPase Rnd1 suppresses mammary tumorigenesis and EMT by restraining Ras-MAPK signalling.
The role of induction (neoadjuvant) chemotherapy in stage IIIA NSCLC.
The role of the H-ras oncogene in radiation resistance and metastasis.
The role of the oncogenic Rab35 in cancer invasion, metastasis, and immune evasion, especially in leukemia.
The role of the small GTPase Rab31 in cancer.
The secretory small GTPase Rab27B as a marker for breast cancer progression.
The Small GTPase ARF6 Activates PI3K in Melanoma to Induce a Prometastatic State.
The small GTPase ARF6 regulates protein trafficking to control cellular function during development and in disease.
The Small GTPase ARF6 Stimulates ?-Catenin Transcriptional Activity During WNT5A-Mediated Melanoma Invasion and Metastasis.
The suppressor of metastasis Nm23-H1 interacts with the Cdc42 Rho family member and the pleckstrin homology domain of oncoprotein Dbl-1 to suppress cell migration.
The V-ATPase-inhibitor Archazolid abrogates tumor metastasis via inhibition of endocytic activation of the Rho-GTPase Rac1.
Timing of Novel Drug 1A-116 to Circadian Rhythms Improves Therapeutic Effects against Glioblastoma.
Tn antigen promotes human colorectal cancer metastasis via H-Ras mediated epithelial-mesenchymal transition activation.
TNF-? augments CXCL10/CXCR3 axis activity to induce Epithelial-Mesenchymal Transition in colon cancer cell.
Traditional Chinese medicine Jianpi Bushen therapy suppresses the onset of pre-metastatic niche in a murine model of spontaneous lung metastasis.
Triptolide Inhibits Breast Cancer Cell Metastasis Through Inducing the Expression of miR-146a, a Negative Regulator of Rho GTPase.
Tumor markers in colorectal cancer, gastric cancer and gastrointestinal stromal cancers: European group on tumor markers 2014 guidelines update.
Tumor metastasis suppressor nm23H1 regulates Rac1 GTPase by interaction with Tiam1.
Tumor regression grades, K-RAS mutational profile and c-MET in colorectal liver metastases.
Ubc9 promotes breast cell invasion and metastasis in a sumoylation-independent manner.
Unraveling the molecular mechanism of interactions of the Rho GTPases Cdc42 and Rac1 with the scaffolding protein IQGAP2.
Upregulated expression of ROCK1 promotes cell proliferation by functioning as a target of miR-335-5p in non-small cell lung cancer.
Upregulation of non-mutated H-ras and its upstream and downstream signaling proteins in colorectal cancer.
Upregulation of ROCK2 in gastric cancer cell promotes tumor cell proliferation, metastasis and invasion.
Vaccination against RhoC induces long-lasting immune responses in patients with prostate cancer: results from a phase I/II clinical trial.
Vacuolar H+ ATPase expression and activity is required for Rab27B-dependent invasive growth and metastasis of breast cancer.
VAMP8, a vesicle-SNARE required for RAB37-mediated exocytosis, possesses a tumor metastasis suppressor function.
Variegated RHOA mutations in human cancers.
Wnt5b promotes the cell motility essential for metastasis of oral squamous cell carcinoma through active Cdc42 and RhoA.
ZEB1 drives prometastatic actin cytoskeletal remodeling by downregulating miR-34a expression.
[A Case of Rectal Cancer with Unresectable Liver Metastasis Responding to Rechallenge with FOLFIRI].
[A case of remnant liver metastases after resection of liver metastases from rectal cancer following treatment with 5-FU, L-OHP and CPT-11, with markedly effective treatment by cetuximab plus S-1].
[A resected case of metastatic pancreatic cancer from cecal carcinoma]
[Ablation of p120-Catenin Altering the Activity of Small GTPase in Human Lung Cancer Cells.]
[Alterations in metastatic properties of hepatocellular carcinoma cell following H-ras oncogene transfection]
[Association of mutations of K-RAS oncogene and deletions of 18Q with lymph node metastasis of colorectal cancer]
[Cell kinetics of colorectal tumors with assessment by K-ras mutation and PCNA labeling index]
[Clinical significance of K-RAS and cytokeratine 20 markers in diagnosis of lymphogenic metastasis of pancreatic cancer]
[Clinical significance of p21H-ras expression and H-ras codon 12 mutation in squamous intraepithelial lesion (SIL) and carcinoma of uterine cervix]
[Detection of hepatic micrometastasis in ductal pancreatic carcinoma by K-ras mutation analysis and determination of clinical relevance]
[Effect of Cdc42 gene inhibited on proliferation, migration and invasion in human hepatocellular carcinoma cells].
[Effects of K-ras gene mutation on colon cancer cell line Caco-2 metastasis by regulating E-cadherin/beta-catenin/p120 protein complex formation and RhoA protein activity]
[Evaluation of prognostic factors in gynecological cancer examined by molecular biological study]
[Experiment study on the diagnostic value of bile K-ras gene mutation responsible to the hepatic metastasis of pancreatic cancer]
[Genetic investigations for lung carcinoma]
[HMGB1-a as potential target for therapy of hematological malignancies].
[K-ras mutation as a prognostic factor in colorectal carcinoma]
[Prevalence of K-ras gene mutations in human colorectal cancers]
[Prognostic value of K-ras gene mutation in colorectal cancer]
[Proteome study of colorectal cancer genesis and hepatic metastasis]
[Relationships between intrahepatic metastasis of hepatocellular carcinoma and in situ microenvironment, and the abundance of nm23-H1 H-ras mRNA]
[Role of Rho GTPase in inhibiting metastatic ability of human prostate cancer cell line PC-3 by omega-3 polyunsaturated fatty acid]
[Study of DNA microarray chip of associated genes of hydatidiform mole]
[Study on relationship of the K-ras mutation with the occurrence of colorectal liver metastasis and survival outcomes].
[The effect of antisense H-ras on growth and metastasis of a high metastatic tumor model of human hepatoma in nude mice LCI-D20]
[The relationship between lymphangiogenesis and lymphatic metastasis in murine hepatic carcinoma of high and low metastatic potentialities.]
[Value of fecal and blood adenomatous polyposis coli gene and K-ras gene mutation detection in colorectal neoplasm screening]
Neoplasm Micrometastasis
A Colorimetric Method for Detection of K-ras Codon 12 Point Mutations in DNA Extracted from Tissue and Peripheral Blood in Pancreatic Disorders.
Clinical application of K-ras oncogene mutations in pancreatic carcinoma: detection of micrometastases.
Detection of extrapancreatic nerve plexus invasion of pancreatic adenocarcinoma. Cytokeratin 19 staining and K-ras mutation.
Detection of multiple hepatic micrometastases in pancreatic adenocarcinoma with a solitary liver metastasis by direct sequencing of the K-ras gene: a case report.
Detection of mutant K-ras in dissected paraaortic lymph nodes of patients with pancreatic adenocarcinoma.
Discordance between K-ras mutations in bone marrow micrometastases and the primary tumor in colorectal cancer.
Peptide nucleic acid clamp PCR: a novel K-ras mutation detection assay for colorectal cancer micrometastases in lymph nodes.
Prognostic value of genetically diagnosed lymph node micrometastasis in non-small cell lung carcinoma cases.
Quantitative detection of mutant alleles of the K-ras gene with minor groove binder-conjugated fluorogenic DNA probes.
Targeting TRAF3IP2, Compared to Rab27, is More Effective in Suppressing the Development and Metastasis of Breast Cancer.
Tumour-derived mutated K-ras codon 12 expression in regional lymph nodes of stage II colorectal cancer patients is not associated with increased risk of cancer-related death.
[Detection of hepatic micrometastasis in ductal pancreatic carcinoma by K-ras mutation analysis and determination of clinical relevance]
[K-ras mutation and liver micrometastasis in colorectal cancer]
[K-ras mutations detection in paraaortic lymph nodes and its prognostic value after the surgical treatment of pancreas cancer]
Neoplasm, Residual
Detection of isolated tumor cells by polymerase chain reaction-restriction fragment length polymorphism for K-ras mutations in tissue samples of 199 colorectal cancer patients.
Prognostic implications of routine, immunohistochemical, and molecular staging in resectable pancreatic adenocarcinoma.
Therapy for regionally unresectable pancreatic cancer.
Neoplasms
"Low-risk" and "high-risk" HPV-infection and K-ras gene point mutations in human cervical cancer: a study of 31 cases.
(1)H, (13)C and (15)N resonance assignment for the human K-Ras at physiological pH.
(1)H, (15)N and (13)C backbone assignments of GDP-bound human H-Ras mutant G12V.
100% HUMAN MONOCLONAL ANTIBODIES IN ONCOLOGY: HYPE OR BREAKTHROUGH?
12th codon mutation resulting in c-N-ras activation in acute myelogenous leukemia.
14-3-3 proteins regulate Tctp-Rheb interaction for organ growth in Drosophila.
14-3-3gamma induces oncogenic transformation by stimulating MAP kinase and PI3K signaling.
2D-PAGE of ovarian cancer: analysis of soluble and insoluble fractions using medium-range immobilized pH gradients.
4-nitrophenol exposure in T24 human bladder cancer cells promotes proliferation, motilities, and epithelial-to-mesenchymal transition.
5' transcript replacement in vitro catalyzed by a group I intron-derived ribozyme.
5'-AMP-activated protein kinase activity is elevated early during primary brain tumor development in the rat.
5-Aza-2'-deoxycytidine is chemopreventive in a 4-(methyl-nitrosamino)-1-(3-pyridyl)-1-butanone-induced primary mouse lung tumor model.
68Ga-labeled oligonucleotides for in vivo imaging with PET.
8-Hydroxyquinoline-based inhibitors of the Rce1 protease disrupt Ras membrane localization in human cells.
?-Arrestin2 regulates lysophosphatidic acid-induced human breast tumor cell migration and invasion via Rap1 and IQGAP1.
?-Catenin activates Rho GTPase, promotes lymphangiogenesis and growth of tumor metastases.
?-Catenin and K-RAS synergize to form primitive renal epithelial tumors with features of epithelial Wilms' tumors.
?Np63? suppresses cells invasion by downregulating PKC?/Rac1 signaling through miR-320a.
A cell line from a human ovarian carcinoma with amplification of the K-ras gene.
A central role for Foxp3+ regulatory T cells in K-Ras-driven lung tumorigenesis.
A chemical biology screen reveals a role for Rab21-mediated control of actomyosin contractility in fibroblast-driven cancer invasion.
A clinicopathologic and immunohistochemical study of 22 intraductal papillary mucinous neoplasms of the pancreas, with a review of the literature.
A Colorimetric Method for Detection of K-ras Codon 12 Point Mutations in DNA Extracted from Tissue and Peripheral Blood in Pancreatic Disorders.
A commercial real-time PCR kit provides greater sensitivity than direct sequencing to detect KRAS mutations: a morphology-based approach in colorectal carcinoma.
A comprehensive survey of Ras mutations in cancer.
A Covalent Calmodulin Inhibitor as a Tool to Study Cellular Mechanisms of K-Ras-Driven Stemness.
A CRISPR-Cas9 repressor for epigenetic silencing of KRAS.
A Cyp2a polymorphism predicts susceptibility to NNK-induced lung tumorigenesis in mice.
A detailed analysis of K-ras point mutations in relation to tumor progression and survival in colorectal cancer patients.
A disconnect between antitumor and antiangiogenic effects of fluvastatin in vitro and in vivo.
A double germline mutations in the APC and p53 genes.
A dualistic model for endometrial carcinogenesis based on immunohistochemical and molecular genetic analyses.
A farnesyltransferase inhibitor induces tumor regression in transgenic mice harboring multiple oncogenic mutations by mediating alterations in both cell cycle control and apoptosis.
A fast and convenient new technique to detect the therapeutic target, K-ras mutant, from peripheral blood in non-small cell lung cancer patients.
A fast, sensitive and accurate high resolution melting (HRM) technology-based assay to screen for common K-ras mutations.
A fluorescence resonance energy transfer activation sensor for Arf6.
A gene expression signature associated with "K-Ras addiction" reveals regulators of EMT and tumor cell survival.
A genetically defined mouse ovarian carcinoma model for the molecular characterization of pathway-targeted therapy and tumor resistance.
A genome-wide Drosophila epithelial tumorigenesis screen identifies Tetraspanin 29Fb as an evolutionarily conserved suppressor of Ras-driven cancer.
A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene.
A germ-line p53 mutation accelerates pulmonary tumorigenesis: p53-independent efficacy of chemopreventive agents green tea or dexamethasone/myo-inositol and chemotherapeutic agents taxol or adriamycin.
A Guanidyl-Based Bivalent Peptidomimetic Inhibits K-Ras Prenylation and Association with c-Raf.
A highly sensitive method for K-ras mutation detection is useful in diagnosis of gastrointestinal cancer.
A Historic Perspective and Overview of H-Ras Structure, Oncogenicity, and Targeting.
A Jnk-Rho-Actin remodeling positive feedback network directs Src-driven invasion.
A K-ras 13Gly-->Asp mutation is recognized by HLA-DQ7 restricted T cells in a patient with colorectal cancer. Modifying effect of DQ7 on established cancers harbouring this mutation?
A Light-Driven Therapy of Pancreatic Adenocarcinoma Using Gold Nanorods-Based Nanocarriers for Co-Delivery of Doxorubicin and siRNA.
A Macropinocytosis-Intensifying Albumin Domain-Based scFv Antibody and Its Conjugate Directed against K-Ras Mutant Pancreatic Cancer.
A member of the Ras oncogene family, RAP1A, mediates antileishmanial activity of monastrol.
A method for the second-site screening of K-Ras in the presence of a covalently attached first-site ligand.
A microplate assay for K-ras genotyping.
A molecular approach to leukemogenesis: mouse lymphomas contain an activated c-ras oncogene.
A mouse strain defective in both T cells and NK cells has enhanced sensitivity to tumor induction by plasmid DNA expressing both activated H-Ras and c-Myc.
A multi-functional imaging approach to high-content protein interaction screening.
A murine model for the development of melanocytic nevi and their progression to melanoma.
A Murine Model of K-RAS and ?-Catenin Induced Renal Tumors Expresses High Levels of E2F1 and Resembles Human Wilms Tumor.
A New Class of Orthosteric uPAR•uPA Small-Molecule Antagonists Are Allosteric Inhibitors of the uPAR•Vitronectin Interaction.
A new facet of NDRG1 in pancreatic ductal adenocarcinoma: Suppression of glycolytic metabolism.
A New Strategy to Control and Eradicate "Undruggable" Oncogenic K-RAS-Driven Pancreatic Cancer: Molecular Insights and Core Principles Learned from Developmental and Evolutionary Biology.
A New View of Ras Isoforms in Cancers.
A novel activating mutation of the K-ras gene in human primary colon adenocarcinoma.
A novel caveolin-1/p85?/Rab5/Tiam1/Rac1 signaling axis in tumor cell migration and invasion.
A Novel CDC42 Mutation in an 11-Year Old Child Manifesting as Syndromic Immunodeficiency, Autoinflammation, Hemophagocytic Lymphohistiocytosis, and Malignancy: A Case Report.
A novel high-specificity approach for colorectal neoplasia: Detection of K-ras2 oncogene mutation in normal mucosa.
A novel hybrid peptide targeting EGFR-expressing cancers.
A novel K-ras mutation in colorectal cancer. A case report and literature review.
A novel method for the production of fully modified K-Ras 4B.
A novel molecular staging protocol for non-small cell lung cancer.
A Novel Pharmacologic Activity of Ketorolac for Therapeutic Benefit in Ovarian Cancer Patients.
A novel point mutation at codon 146 of the K-ras gene in a human colorectal cancer identified by the polymerase chain reaction.
A novel Ras antagonist regulates both oncogenic Ras and the tumor suppressor p53 in colon cancer cells.
A novel role of Rho-kinase in the regulation of ligand-induced phosphorylated EGFR endocytosis via the early/late endocytic pathway in human fibrosarcoma cells.
A novel splice variant of GLI1 that promotes glioblastoma cell migration and invasion.
A novel strategy for specifically down-regulating individual Rho GTPase activity in tumor cells.
A one-step DGGE scanning method for detection of mutations in the K-, N-, and H-ras oncogenes: mutations at codons 12, 13 and 61 are rare in B-cell non-Hodgkin's lymphoma.
A panel of high resolution melting (HRM) technology-based assays with direct sequencing possibility for effective mutation screening of EGFR and K-ras genes.
A PCR-RFLP method for the detection of activated H-ras oncogene with a point mutation at codon 12 and 61.
A personalized treatment for lung cancer: molecular pathways, targeted therapies, and genomic characterization.
A phase I study of BMS-690514 in Japanese patients with advanced or metastatic solid tumors.
A Phase I trial of H-ras antisense oligonucleotide ISIS 2503 administered as a continuous intravenous infusion in patients with advanced carcinoma.
A phase I trial of ISIS 2503, an antisense inhibitor of H-ras, in combination with gemcitabine in patients with advanced cancer.
A position 12-activated H-ras oncogene in all HS578T mammary carcinosarcoma cells but not normal mammary cells of the same patient.
A possible multiclonal development in human colonic carcinomas.
A preliminary result of three-dimensional microarray technology to gene analysis with endoscopic ultrasound-guided fine-needle aspiration specimens and pancreatic juices.
A quantitative volumetric micro-computed tomography method to analyze lung tumors in genetically engineered mouse models.
A Rac1/Cdc42 GTPase-Specific Small Molecule Inhibitor Suppresses Growth of Primary Human Prostate Cancer Xenografts and Prolongs Survival in Mice.
A randomized trial comparing preoperative chemotherapy plus surgery with surgery alone in patients with non-small-cell lung cancer.
A relationship between K-ras gene mutations and some clinical and histologic variables in patients with primary colorectal carcinoma.
A repeated pancreatectomy in the remnant pancreas 22 months after pylorus-preserving pancreatoduodenectomy for pancreatic adenocarcinoma.
A role for activated Cdc42 in glioblastoma multiforme invasion.
A role for K-ras in conferring resistance to the MEK inhibitor, CI-1040.
A Role for Mitochondrial Translation in Promotion of Viability in K-Ras Mutant Cells.
A Role for PP1/NIPP1 in Steering Migration of Human Cancer Cells.
A role for small GTPase RhoA in regulating intracellular membrane traffic of lysosomes in invasive rat hepatoma cells.
A Sensitized Screen for Genes Promoting Invadopodia Function In Vivo: CDC-42 and Rab GDI-1 Direct Distinct Aspects of Invadopodia Formation.
A study of ras gene mutations in colonic adenomas from familial polyposis coli patients.
A synthetic lethal interaction between K-Ras oncogenes and Cdk4 unveils a therapeutic strategy for non-small cell lung carcinoma.
A Targeted Quantitative Proteomic Approach Assesses the Reprogramming of Small GTPases during Melanoma Metastasis.
A transforming Kirsten ras oncogene in an oral squamous carcinoma.
A unifying mechanism in the initiation of cancer and other diseases by catechol quinones.
A universal method for the mutational analysis of K-ras and p53 gene in non-small-cell lung cancer using formalin-fixed paraffin-embedded tissue.
A vertically stacked, polymer, microfluidic point mutation analyzer: Rapid high accuracy detection of low-abundance K-ras mutations.
A very large villous adenoma with an adjacent cancer of the rectum: an informative case for testing the proposed molecular basis of colorectal tumorigenesis.
AAV9-mediated telomerase activation does not accelerate tumorigenesis in the context of oncogenic K-Ras-induced lung cancer.
Aberrant deoxyribonucleic acid methylation in human thyroid tumors.
Aberrant expression of the K-ras proto-oncogene in B-cell malignancies.
Aberrant G protein signaling in nervous system tumors.
Aberrations of the K-ras, p53, and APC genes in extrahepatic bile duct cancer.
Abnormal expression of p120-catenin, E-cadherin, and small GTPases is significantly associated with malignant phenotype of human lung cancer.
Abnormal expression of Rap2A as a prognostic marker for human breast cancer.
Abrogation of RAB27A expression transiently affects melanoma cell proliferation.
Absence of activating mutations in ras and gsp oncogenes in a cohort of nine patients with sporadic pediatric thyroid tumors.
Absence of H- and K-ras oncogene mutations in sporadic medullary thyroid carcinoma.
Absence of H-ras point mutation at codon 12 in N-methyl-N-nitrosourea-induced hepatocellular neoplasms in the rat.
Absence of p53 gene mutations in rat colon carcinomas induced by azoxymethane.
Absence of p53 mutations in methylnitrosourea-induced mammary tumors in rats.
Absent ras gene mutations in human adrenal cortical neoplasms and pheochromocytomas.
Absolute quantification of farnesylated Ras levels in complex samples using liquid chromatography fractionation combined with tryptic digestion and electrospray tandem mass spectrometry.
ACB-PCR measurement of H-ras codon 61 CAA?CTA mutation provides an early indication of aristolochic acid I carcinogenic effect in tumor target tissues.
ACB-PCR measurement of K-ras codon 12 mutant fractions in livers of Big Blue rats treated with N-hydroxy-2-acetylaminofluorene.
ACB-PCR measurement of spontaneous and furan-induced H-ras Codon 61 CAA to CTA and CAA to AAA mutation in B6C3F1 mouse liver.
ACB-PCR quantification of K-RAS codon 12 GAT and GTT mutant fraction in colon tumor and non-tumor tissue.
Accomplishments in 2007 in biologic markers for gastrointestinal cancers.
Acinar-ductal-carcinoma sequence in transforming growth factor-alpha transgenic mice.
Ack promotes tissue growth via phosphorylation and suppression of the Hippo pathway component Expanded.
ACK1 is dispensable for development, skin tumor formation, and breast cancer cell proliferation.
Acquired glucose sensitivity of k-ras transformed fibroblasts.
Acquired resistance to gefitinib: The contribution of mechanisms other than the T790M, MET, and HGF status.
Across The Universe Of K-Ras Mutations In Non-Small-Cell-Lung Cancer.
Activated fibroblast growth factor receptor 3 is an oncogene that contributes to tumor progression in multiple myeloma.
Activated H-ras oncogenes in human kidney tumors.
Activated K-ras and INK4a/Arf deficiency cooperate during the development of pancreatic cancer by activation of Notch and NF-?B signaling pathways.
Activated K-Ras and INK4a/Arf deficiency promote aggressiveness of pancreatic cancer by induction of EMT consistent with cancer stem cell phenotype.
Activated K-ras and N-ras oncogenes in primary renal mesenchymal tumors induced in F344 rats by methyl(methoxymethyl)nitrosamine.
Activated K-ras is involved in regulation of integrin expression in human colon carcinoma cells.
Activated Ras induces cytoplasmic vacuolation and non-apoptotic death in glioblastoma cells via novel effector pathways.
Activated ras oncogene collaborates with HBx gene of hepatitis B virus to transform cells by suppressing HBx-mediated apoptosis.
Activated ras oncogenes in human thyroid cancers.
Activated ras protein accelerates cell cycle progression to perturb madin-darby canine kidney cystogenesis.
Activated Rho GTPases in Cancer-The Beginning of a New Paradigm.
Activating K-Ras mutations outwith 'hotspot' codons in sporadic colorectal tumours - implications for personalised cancer medicine.
Activating mutations in the k-ras gene in ulcerative-colitis and crohns-disease.
Activating mutations of N- and K-ras in multiple myeloma show different clinical associations: analysis of the Eastern Cooperative Oncology Group Phase III Trial.
Activating the Expression of Human K-rasG12D Stimulates Oncogenic Transformation in Transgenic Goat Fetal Fibroblast Cells.
Activation of a c-K-ras oncogene by somatic mutation in mouse lymphomas induced by gamma radiation.
Activation of c-myc and c-K-ras oncogenes in primary rat tumors induced by ionizing radiation.
Activation of clg, a novel dbl family guanine nucleotide exchange factor gene, by proviral insertion at evi24, a common integration site in B cell and myeloid leukemias.
Activation of H-ras is prevalent in 1,3-butadiene-induced and spontaneously occurring murine Harderian gland tumors.
Activation of H-ras oncogene in rat bladder tumors induced by N-butyl-N-(4-hydroxybutyl)nitrosamine.
Activation of H-ras oncogenes in male B6C3F1 mouse liver tumors induced by vinthionine or 2-chloroethyl-methyl sulfide.
Activation of H-ras oncogenes in preneoplastic mouse mammary tissues.
Activation of Harvey ras oncogene by mutation at codon 12 is very rare in hemopoietic malignancies.
Activation of K-RAS by co-mutation of codons 19 and 20 is transforming.
Activation of K-ras by codon 13 mutations in C57BL/6 X C3H F1 mouse tumors induced by exposure to 1,3-butadiene.
Activation of K-ras in aflatoxin B1-induced lung tumors from AC3F1 (A/J x C3H/HeJ) mice.
Activation of K-ras in transplantable pancreatic ductal adenocarcinomas of Syrian golden hamsters.
Activation of nuclear factor-kappaB p50 homodimer/Bcl-3 complexes in nasopharyngeal carcinoma.
Activation of proto-oncogenes in human and mouse lung tumors.
Activation of protooncogenes in mouse lung tumors.
Activation of Rap1 promotes prostate cancer metastasis.
Activation of RAS family genes in urothelial carcinoma.
Activation of ras oncogenes preceding the onset of neoplasia.
Activation of RhoB by hypoxia controls hypoxia-inducible factor-1alpha stabilization through glycogen synthase kinase-3 in U87 glioblastoma cells.
Activation of the K-ras gene by insertion mutations in chemically induced rat renal mesenchymal tumors.
Activation of the K-ras oncogene in colorectal neoplasms is associated with decreased apoptosis.
Activation of the K-ras oncogene in liver tumors of Hudson River tomcod.
Activation of the K-ras protooncogene in lung tumors from rats and mice chronically exposed to tetranitromethane.
Activation of the Raf/MAP kinase cascade by the Ras-related protein TC21 is required for the TC21-mediated transformation of NIH 3T3 cells.
Activation of the Ran GTPase is subject to growth factor regulation and can give rise to cellular transformation.
Activation of the small GTPase Cdc42 by the inflammatory cytokines TNF(alpha) and IL-1, and by the Epstein-Barr virus transforming protein LMP1.
Active RAC1 Promotes Tumorigenic Phenotypes and Therapy Resistance in Solid Tumors.
Additional evidence that the K-ras protooncogene is a candidate for the major mouse pulmonary adenoma susceptibility (Pas-1) gene.
Additional value of K-ras point mutations in bronchial wash fluids for diagnosis of peripheral lung tumours.
Adenocarcinoma of the pancreas: detection of occult metastases in regional lymph nodes by a polymerase chain reaction-based assay.
Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth.
Adenosine promotes tumor metastasis.
Adenovirus-mediated anti-K-ras ribozyme induces apoptosis and growth suppression of human pancreatic carcinoma.
ADP-ribosylation factor 6 regulates tumor cell invasion through the activation of the MEK/ERK signaling pathway.
ADP-ribosylation factor 6 regulates tumorigenic and invasive properties in vivo.
ADP-ribosylation of oncogenic Ras proteins by pseudomonas aeruginosa exoenzyme S in vivo.
Advances in Molecular Pathology and Treatment of Periampullary Cancers.
Advances in the molecular genetics of endometrial cancer (Review).
AFAP1-AS1, a long noncoding RNA upregulated in lung cancer and promotes invasion and metastasis.
Afatinib restrains K-RAS-driven lung tumorigenesis.
Ag3PO4 NP@MoS2 nanosheet enhanced F, S-doped BN quantum dot electrochemiluminescence biosensor for K-ras tumor gene detection.
AKT and cancer--is it all mTOR?
Akt pathway activation converts anaplastic astrocytoma to glioblastoma multiforme in a human astrocyte model of glioma.
Akt phosphorylation of deleted in liver cancer 1 abrogates its suppression of liver cancer tumorigenesis and metastasis.
Akt/protein kinase B is constitutively active in non-small cell lung cancer cells and promotes cellular survival and resistance to chemotherapy and radiation.
Akt1 deletion prevents lung tumorigenesis by mutant K-ras.
Alcohol consumption and distinct molecular pathways to colorectal cancer.
Allele-specific activation and expression of the K-ras gene in hybrid mouse lung tumors induced by chemical carcinogens.
Allele-specific detection of K-ras oncogene expression in human non-small-cell lung carcinomas.
Allele-specific, non-extendable primer blocker PCR (AS-NEPB-PCR) for DNA mutation detection in cancer.
Allelic loss of susceptibility loci and the occurrence of BRAF and RAS mutations in patients with familial non-medullary thyroid cancer.
Allelotype analysis of mouse lung carcinomas reveals frequent allelic losses on chromosome 4 and an association between allelic imbalances on chromosome 6 and K-ras activation.
Allosteric Activation of GDP-Bound Ras Isoforms by Bisphenol Derivative Plasticisers.
Allosteric binding sites in Rab11 for potential drug candidates.
Alpha-tubulin acetyltransferase/MEC-17 regulates cancer cell migration and invasion through epithelial-mesenchymal transition suppression and cell polarity disruption.
ALS2, the small GTPase Rab17-interacting protein, regulates maturation and sorting of Rab17-associated endosomes.
Alteration of the p53 tumor suppressor gene occurs independently of K-ras activation and more frequently in serous adenocarcinomas than in other common epithelial tumors of the human ovary.
Alterations in K-ras, APC and p53-multiple genetic pathway in colorectal cancer among Indians.
Alterations in membrane-bound and cytoplasmic K-ras protein levels in mouse lung induced by treatment with lovastatin, cholestyramine, or niacin: effects are highly mouse strain dependent.
Alterations in the K-ras and p53 genes in rat lung tumors.
Alterations of K-ras and p53 mutations in colorectal cancer patients in Central Europe.
Alterations of K-ras, p53, and erbB-2/neu in human lung adenocarcinomas.
Alterations of oncogenes, tumor suppressor genes and growth factors in hepatocellular carcinoma: with relation to tumor size and invasiveness.
Alterations of p53, cyclin D1, Rb, and H-ras in human oral carcinomas related to tobacco use.
Alterations of protein kinase C, 8-hydroxydeoxyguanosine, and K-ras oncogene in rat lungs exposed to passive smoking.
Alterations of the K-ras and p53 genes and microsatellite instability in sporadic colorectal carcinomas.
Alterations of the K-ras and p53 genes in Tamoxifen-associated endometrial carcinoma.
Alterations of the p53 tumor suppressor gene and its association with activation of the c-K-ras-2 protooncogene in premalignant and malignant lesions of the human uterine endometrium.
Alterations of tumor suppressor genes and the H-ras oncogene in oral squamous cell carcinoma.
Altered adhesive structures and their relation to RhoGTPase activation in merlin-deficient Schwannoma.
Altered detoxification status and increased resistance to oxidative stress by K-ras transformation.
Altered gene expression profiles of NIH3T3 cells regulated by human lung cancer associated gene CT120.
Altered intracellular region of MUC1 and disrupted correlation of polarity-related molecules in breast cancer subtypes.
Alternative splicing of the K-ras gene in mouse tissues and cell lines.
Alternative splicing of TIA-1 in human colon cancer regulates VEGF isoform expression, angiogenesis, tumour growth and bevacizumab resistance.
American College of Radiology thyroid imaging report and data system combined with K-RAS mutation improves the management of cytologically indeterminate thyroid nodules.
Amplification of epidermal growth factor receptor gene but no evidence of ras mutations in primary human esophageal cancers.
Amplification of the N-myc oncogene in an adenocarcinoma cell line of the lung.
Amplification of wild-type K-ras promotes growth of head and neck squamous cell carcinoma.
An adenosine-mediated signaling pathway suppresses prenylation of the GTPase Rap1B and promotes cell scattering.
An adenovirus inhibitor of tumor necrosis factor alpha-induced apoptosis complexes with dynein and a small GTPase.
An attempt to isolate genes responsible for spontaneous and experimental metastasis in the mouse model.
An ex(o)citing machinery for invasive tumor growth.
An expanding role for RAS GTPase activating proteins (RAS GAPs) in cancer.
An immune escape screen reveals Cdc42 as regulator of cancer susceptibility to lymphocyte-mediated tumor suppression.
An important role for Myb-MuvB and its target gene KIF23 in a mouse model of lung adenocarcinoma.
An overview of genetic mutations and epigenetic signatures in the course of pancreatic cancer progression.
An unexpected new role of mutant Ras: perturbation of human embryonic development.
Analogues and Derivatives of Oncrasin-1, a Novel Inhibitor of the C-Terminal Domain of RNA Polymerase II and Their Antitumor Activities.
Analyses on K-ras mutations and fascin expression in patients with cardia cancer.
Analysis of activated protooncogenes in B6C3F1 mouse liver tumors induced by ciprofibrate, a potent peroxisome proliferator.
Analysis of h-ras, k-ras and N-ras genes for expression, mutation and amplification in laryngeal tumors.
Analysis of HER-3, insulin growth factor-1, nuclear factor-kB and epidermal growth factor receptor gene copy number in the prediction of clinical outcome for K-RAS wild-type colorectal cancer patients receiving irinotecan-cetuximab.
Analysis of K-ras and p53 mutations in mesotheliomas from humans and rats exposed to asbestos.
Analysis of K-RAS and P53 mutations in sputum samples.
Analysis of K-ras codon 12 and TP53 mutations in patients with advanced colorectal carcinoma.
Analysis of K-ras codon 12 mutations and p53 overexpression in colorectal nodule-aggregating tumors.
Analysis of K-ras gene mutations in human pancreatic cancer cell lines and in bile samples from patients with pancreatic and biliary cancers.
Analysis of K-ras gene mutations in malignant and nonmalignant endobronchial tissue obtained by fiberoptic bronchoscopy.
Analysis of K-ras gene mutations in periampullary cancers, gallbladder cancers and cholangiocarcinomas from paraffin-embedded tissue sections.
Analysis of K-ras gene mutations in rare pancreatic and ampullary tumours.
Analysis of K-Ras Interactions by Biotin Ligase Tagging.
Analysis of K-ras mutations and expression of cyclooxygenase-2 and gastrin protein in laterally spreading tumors.
Analysis of K-ras mutations in pancreatic tissue after fine needle aspirates.
Analysis of K-ras oncogene mutation directly applied to atypical cell clusters on cytologic smear slides of bile and pancreatic juice.
Analysis of K-ras, APC, and beta-catenin in aberrant crypt foci in sporadic adenoma, cancer, and familial adenomatous polyposis.
Analysis of K-ras, BRAF, and PIK3CA mutations in laterally-spreading tumors of the colorectum.
Analysis of K-ras, N-ras, H-ras, and p53 in lung neuroendocrine neoplasms.
Analysis of K-ras, p53 and c-raf-1 mutations in beryllium-induced rat lung tumors.
Analysis of loss of heterozygosity in atypical and negative bile duct brushing cytology specimens with malignant outcome: are "false-negative" cytologic findings a representation of morphologically subtle molecular alterations?
Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras.
Analysis of mutations in B-RAF, N-RAS, and H-RAS genes in the differential diagnosis of Spitz nevus and spitzoid melanoma.
Analysis of mutations in the K-ras and p53 genes of lung tumors and in the hprt gene of 6-thioguanine-resistant T-lymphocytes from rats treated with 1,6-dinitropyrene.
Analysis of N- and K-ras mutations in the distinctive tumor progression phases of melanoma.
Analysis of p53 and K-ras genes and their proteins in a sarcoma botryoides of the uterine cervix.
Analysis of p53 tumor suppressor gene, H-ras protooncogene and proliferating cell nuclear antigen (PCNA) in squamous cell carcinomas of HRA/Skh mice following exposure to 8-methoxypsoralen (8-MOP) and UVA radiation (PUVA therapy).
Analysis of ras gene mutations in biliary and pancreatic tumors by polymerase chain reaction and direct sequencing.
Analysis of ras gene mutations in hepatocellular carcinoma in southern African blacks.
Analysis of ras gene mutations in human hepatic malignant tumors by polymerase chain reaction and direct sequencing.
Analysis of RIN1 gene expression in colorectal cancer.
Analysis of somatic molecular changes, clinicopathological features, family history, and germline mutations in colorectal cancer families: evidence for efficient diagnosis of HNPCC and for the existence of distinct groups of non-HNPCC families.
Analysis of the allele-specific PCR method for the detection of neoplastic disease.
Analysis of the c-myc, K-ras and p53 genes in methylcholanthrene-induced mouse sarcomas.
Analysis of the expression and potential molecular mechanism of interleukin-1 receptor antagonist (IL1RN) in papillary thyroid cancer via bioinformatics methods.
Analysis of the Harvey ras gene in cisplatin-initiated mouse skin tumors by polymerase chain reaction and direct DNA sequencing.
Analysis of the K-ras and p53 pathways in X-ray-induced lung tumors in the rat.
Analysis of the K-ras/B-raf/Erk signal cascade, p53 and CMAP as markers for tumor progression in colorectal cancer patients.
Analysis of tumor progression by transcriptional profiling of mouse MK16 cell lines transformed with human papillomavirus type 16 E6 and E7 oncogenes and activated H-ras.
Analysis of tumor-host interactions by gene expression profiling of lung adenocarcinoma xenografts identifies genes involved in tumor formation.
Analyzing time-series microarray data reveals key genes in spinal cord injury.
Anaplastic Lymphoma Kinase (ALK) Kinase Domain Mutation Following ALK Inhibitor(s) Failure in Advanced ALK Positive Non-Small-Cell Lung Cancer: Analysis and Literature Review.
Anchorage-independent growth and the expression of cellular proto-oncogenes in normal human epidermal keratinocytes and in human squamous cell carcinoma cell lines.
Androgen receptor splice variants bind to constitutively open chromatin and promote abiraterone-resistant growth of prostate cancer.
Aneuploidy mechanisms in human colorectal preneoplastic lesions and Barrett's esophagus. Is there a role for K-ras and p53 mutations?
Angiogenesis and p53 and H-ras mutations in pancreatic ductal adenocarcinoma.
Animal Models of Beryllium-induced Lung Disease
Animal models of beryllium-induced lung disease.
Animal products and K-ras codon 12 and 13 mutations in colon carcinomas.
Another Surprise from Metformin: Novel Mechanism of Action via K-Ras Influences Endometrial Cancer Response to Therapy.
Anti-apoptotic and oncogenic properties of the dsRNA-binding protein of vaccinia virus, E3L.
Anti-K-ras ribozyme induces growth inhibition and increased chemosensitivity in human colon cancer cells.
Anti-tumor activity of antizyme which targets the ornithine decarboxylase (ODC) required for cell growth and transformation.
Anti-tumor activity of ESX1 on cancer cells harboring oncogenic K-ras mutation.
Anti-tumor effects of phenolic alkaloids of menispermum dauricum on gastric cancer in vivo and in vitro.
Anti-tumorigenic effect of a K-ras ribozyme against human lung cancer cell line heterotransplants in nude mice.
Anticancer mechanisms of doxorubicin and zoledronic acid in breast cancer tumor growth in bone.
Anticoagulation therapy promotes the tumor immune-microenvironment and potentiates the efficacy of immunotherapy by alleviating hypoxia.
Antisense oligonucleotides specific to mutated K-ras genes inhibit invasiveness of human pancreatic cancer cell lines.
Antisense therapeutics: lessons from early clinical trials.
Antisense therapy specific to mutated K-ras gene in hamster pancreatic cancer model. Can it inhibit the growth of 5-FU and MMC-resistant metastatic and remetastatic cell lines?
Antitumor activity of a novel oncrasin analogue is mediated by JNK activation and STAT3 inhibition.
Antitumor activity of an oncolytic adenovirus-delivered oncogene small interfering RNA.
Antitumor activity of ER-51785, a new peptidomimetic inhibitor of farnesyl transferase: synergistic effect in combination with paclitaxel.
Antitumor effect of a farnesyl protein transferase inhibitor in mammary and lymphoid tumors overexpressing N-ras in transgenic mice.
Antitumor effects of dioscin in A431 cells via adjusting ATM/p53-mediated cell apoptosis, DNA damage and migration.
Antitumor efficacy of a novel class of non-thiol-containing peptidomimetic inhibitors of farnesyltransferase and geranylgeranyltransferase I: combination therapy with the cytotoxic agents cisplatin, Taxol, and gemcitabine.
Antitumorigenesis of antioxidants in a transgenic Rac1 model of Kaposi's sarcoma.
APC and K-ras gene mutation in aberrant crypt foci of human colon.
APC and p53 mutations in de novo colorectal adenocarcinomas.
APC mutations are sufficient for the growth of early colorectal adenomas.
APC, K-ras codon 12 mutations and p53 gene expression in carcinoma and adenoma of the gall-bladder suggest two genetic pathways in gall-bladder carcinogenesis.
APC, K-ras, and p53 gene mutations in colorectal cancer patients: correlation to clinicopathologic features and postoperative surveillance.
Aphanin, a triterpenoid from Amoora rohituka inhibits K-Ras mutant activity and STAT3 in pancreatic carcinoma cells.
Apolipoprotein E4 genotype compromises brain exosome production.
Apoptosis in relation to proliferating cell nuclear antigen and Dukes' stage in colorectal adenocarcinoma.
Apoptosis of human BEL-7402 hepatocellular carcinoma cells released by antisense H-ras DNA--in vitro and in vivo studies.
Apoptotic effects of high-dose rapamycin occur in S-phase of the cell cycle.
Application of clonal analysis. Differential diagnosis for synchronous primary ovarian and endometrial cancers and metastatic cancer.
Application of FTIR microscopy for the characterization of malignancy: H-ras transfected murine fibroblasts as an example.
Application of gene expression profiling to colon cell maturation, transformation and chemoprevention.
Application of the p53 and K-ras gene mutation patterns for cytologic diagnosis of recurrent lung carcinomas.
Application of the restriction site mutation technique to N-methyl-N-nitrosourea-induced mutations in the rat.
Applying Antibodies Inside Cells: Principles and Recent Advances in Neurobiology, Virology and Oncology.
Approach for targeting Ras with small molecules that activate SOS-mediated nucleotide exchange.
Approaches of targeting Rho GTPases in cancer drug discovery.
Approaches to inhibiting oncogenic K-Ras.
Aptamer-derived peptide inhibitors of Rho guanine nucleotide exchange factors.
Are high initial CEA and CA 19-9 levels associated with the presence of K-ras mutation in patients with metastatic colorectal cancer?
Arf6 regulates tumour angiogenesis and growth through HGF-induced endothelial ?1 integrin recycling.
ARF6, induced by mutant Kras, promotes proliferation and Warburg effect in pancreatic cancer.
ARF6-regulated shedding of tumor cell-derived plasma membrane microvesicles.
ARHGAP10, downregulated in ovarian cancer, suppresses tumorigenicity of ovarian cancer cells.
ARHGAP17 suppresses tumor progression and up-regulates P21 and P27 expression via inhibiting PI3K/AKT signaling pathway in cervical cancer.
ARHGAP21 is a RhoGAP for RhoA and RhoC with a role in proliferation and migration of prostate adenocarcinoma cells.
Aristolochic acid as a probable human cancer hazard in herbal remedies: a review.
Aristolochic acid-induced carcinogenesis examined by ACB-PCR quantification of H-Ras and K-Ras mutant fraction.
Assessing sequential oncogene amplification in human breast cancer.
Assessment of in vitro cytotoxic and genotoxic activities of some trimethoprim conjugates.
Assessment of K-ras mutation: a step toward personalized medicine for patients with colorectal cancer.
Assessment of the mutagenicity of dichloroacetic acid in lacI transgenic B6C3F1 mouse liver.
Association between ATL and non-hematopoietic neoplasms.
Association between coffee drinking and K-ras mutations in exocrine pancreatic cancer. PANKRAS II Study Group.
Association between H-ras minisatellite and colorectal cancer risk.
Association between H-RAS T81C genetic polymorphism and gastrointestinal cancer risk: a population based case-control study in China.
Association of deficient DNA repair during G2 phase with progression from benign to malignant state in a line of human skin keratinocytes transfected with ras oncogene.
Association of epidermal growth factor receptor and K-Ras mutations with smoking history in non-small cell lung cancer patients.
Association of genetic variants of O6-methylguanine-DNA methyltransferase with risk of lung cancer in non-Hispanic Whites.
Association of H-ras mutations with adenocarcinomas of the parotid gland.
Association of H-ras polymorphisms and susceptibility to sporadic colon cancer.
Association of K-ras codon 12 transversions with short survival in non-small cell lung cancer.
Association of K-ras mutational status and clinical outcomes in patients with metastatic colorectal cancer receiving panitumumab alone.
Association of K-ras mutations with p16 methylation in human colon cancer.
Association of k-ras, b-raf, and p53 status with the treatment effect of bevacizumab.
Association of matrilysin mRNA expression with K-ras mutations and progression in pancreatic ductal adenocarcinomas.
Association of p53, K-ras and proliferating cell nuclear antigen with rat lung lesions following exposure to simulated nuclear fuel particles.
Association of polymorphisms in AKT1 and EGFR with clinical outcome and toxicity in non-small cell lung cancer patients treated with gefitinib.
Association of sonic hedgehog signaling pathway genes IHH, BOC, RAB23a and MIR195-5p, MIR509-3-5p, MIR6738-3p with gastric cancer stage.
Association of the SS genotype of the L-myc gene and loss of 18q sequences with a worse clinical prognosis in colorectal cancers.
Association of Wilms' tumor with primary brain tumor in siblings.
Associations between markers of colorectal cancer stem cells, mutation, microRNA and the clinical features of ulcerative colitis.
ATR/Chk1/Smurf1 pathway determines cell fate after DNA damage by controlling RhoB abundance.
Attenuated expression and function of the RECK tumor suppressor under hypoxic conditions is mediated by the MAPK signaling pathways.
Augmentation of immune response by an analog of the antigenic peptide in a human T-cell clone recognizing mutated Ras-derived peptides.
Aurora-A phosphorylates, activates, and relocalizes the small GTPase RalA.
Automated real-time PCR to determine K-ras codon 12 mutations in non-small cell lung cancer: comparison with immunohistochemistry and clinico-pathological features.
Autophagy facilitates glycolysis during Ras-mediated oncogenic transformation.
Autophagy in pancreatic cancer pathogenesis and treatment.
B-Raf is dispensable for K-Ras-mediated oncogenesis in human cancer cells.
Bacterial Biotransformation and Anticancer Activities of Betulin against A549, HepG2 and 5RP7 Cancer Cell Lines.
Basic fibroblast growth factor selectively regulates ornithine decarboxylase gene expression in malignant H-ras transformed cells.
BAY61-3606 Affects the Viability of Colon Cancer Cells in a Genotype-Directed Manner.
Bcl-3 promotes multi-modal tumour cell migration via NF-?B1 mediated regulation of Cdc42.
BCR expression is decreased in meningiomas showing loss of heterozygosity of 22q within a new minimal deletion region.
beta-Catenin and ras oncogenes detect most human colorectal cancer.
beta-Catenin mutation is selected during malignant transformation in colon carcinogenesis.
Beta-catenin mutations in liver tumors induced by 2-amino-3,4-dimethylimidazo[4,5-f]quinoline in CDF1 mice.
Bevacizumab in combination with chemotherapy: first-line treatment of patients with metastatic colorectal cancer.
Beyond the Genomic Mutation: Rethinking the Molecular Biomarkers of K-RAS Dependency in Pancreatic Cancers.
Bif-1 promotes tumor cell migration and metastasis via Cdc42 expression and activity.
Biliopancreatic malignancy: screening the at risk patient with molecular markers.
Binding of wild-type and mutant forms of p53 protein from human tumors to a specific DNA-sequence of the first intron of the h-ras oncogene.
Biochemical diagnostics of pancreatic cancer - Present and future.
Biological consequences of the genetic changes which occur during human colorectal carcinogenesis.
Biological identification of ampullary adenocarcinomas.
Biological significance of aminophenyl-?-carboline derivatives formed from co-mutagenic action of ?-carbolines and aniline and o-toluidine and its effect on tumorigenesis in humans: A review.
Biomarker discovery, development, and implementation in france: a report from the French national cancer institute and cooperative groups.
Biomarkers in the ovary.
Bisphenol A binds to Ras proteins and competes with guanine nucleotide exchange: implications for GTPase-selective antagonists.
Black tea extract can modulate protein expression of H-ras, c-Myc, p53, and Bcl-2 genes during pulmonary hyperplasia, dysplasia, and carcinoma in situ.
Blockage of epidermal growth factor receptor-phosphatidylinositol 3-kinase-AKT signaling increases radiosensitivity of K-RAS mutated human tumor cells in vitro by affecting DNA repair.
Blockage of transferred exosome-shuttled miR-494 inhibits melanoma growth and metastasis.
Blocking anaplerotic entry of glutamine into the TCA cycle sensitizes K-Ras mutant cancer cells to cytotoxic drugs.
Blocking K-Ras Interaction With the Plasma Membrane Is a Tractable Therapeutic Approach to Inhibit Oncogenic K-Ras Activity.
Blocking of p53-Snail binding, promoted by oncogenic K-Ras, recovers p53 expression and function.
Bmi-1 Cooperates with H-Ras to Transform Human Mammary Epithelial Cells via Dysregulation of Multiple Growth-Regulatory Pathways.
BNIPL-2 promotes the invasion and metastasis of human hepatocellular carcinoma cells.
Bond swapping from a charge cloud allows flexible coordination of upstream signals through WASP: Multiple regulatory roles for the WASP basic region.
Bone Marrow-Derived Mesenchymal Stem Cells Differentially Affect Glioblastoma Cell Proliferation, Migration, and Invasion: A 2D-DIGE Proteomic Analysis.
Both (+/-)syn- and (+/-)anti-7,12-dimethylbenz[a]anthracene-3,4-diol-1,2-epoxides initiate tumors in mouse skin that possess -CAA- to -CTA- mutations at Codon 61 of c-H-ras.
Both farnesyltransferase and geranylgeranyltransferase I inhibitors are required for inhibition of oncogenic K-Ras prenylation but each alone is sufficient to suppress human tumor growth in nude mouse xenografts.
Both K-ras and H-ras protooncogene mutations are associated with Harderian gland tumorigenesis in B6C3F1 mice exposed to isoprene for 26 weeks.
Both sides of the same coin: Rac1 alternative splicing by EGF signaling.
Bracken fern-induced malignant tumors in rats: absence of mutations in p53, H-ras and K-ras and no microsatellite instability.
BRAF and RAS oncogenes regulate Rho GTPase pathways to mediate migration and invasion properties in human colon cancer cells: a comparative study.
BRAF mutation associated with dysregulation of apoptosis in human colorectal neoplasms.
BRAF mutation is frequently present in sporadic colorectal cancer with methylated hMLH1, but not in hereditary nonpolyposis colorectal cancer.
BRAF mutations characterize colon but not gastric cancer with mismatch repair deficiency.
BRaf signaling principles unveiled by large-scale human mutation analysis with a rapid lentivirus-based gene replacement method.
BRAF, K-ras and BAT26 mutations in colorectal polyps and stool.
BRAF/K-ras mutation, microsatellite instability, and promoter hypermethylation of hMLH1/MGMT in human gastric carcinomas.
BRCA1, C-erbB-2, and H-ras gene expressions in young women with breast cancer. An immunohistochemical study.
Breaking bad family ties: Pan-ERBB blockers inhibit KRAS driven lung tumorigenesis.
Breaking up is hard to do: RalA, mitochondrial fission and cancer.
Bronchioloalveolar lung carcinomas: K-ras mutations are constant events in the mucinous subtype.
c-K-ras overexpression is characteristic for metastases derived from a methylcholanthrene-induced fibrosarcoma.
c-Ki-ras point mutations in ductectatic-type mucinous cystic neoplasms of the pancreas.
C-Raf is required for the initiation of lung cancer by K-Ras.
Cadmium malignantly transforms normal human breast epithelial cells into a basal-like phenotype.
Cadmium modulates H-ras expression and caspase-3 apoptotic cell death in breast cancer epithelial MCF-7 cells.
Calcium regulates podocyte actin dynamics.
Calmodulin and PI3K Signaling in KRAS Cancers.
cAMP inhibition of Akt is mediated by activated and phosphorylated Rap1b.
Can cancer be reversed by engineering the tumor microenvironment?
Can Different Thyroid Tumor Types Be Distinguished by Polymerase Chain Reaction-Based K-ras Mutation Detection?
Cancer stem cell drugs target K-ras signaling in a stemness context.
Cancer targets in the Ras pathway.
Carcinogen and dietary lipid regulate ras expression and localization in rat colon without affecting farnesylation kinetics.
Carcinogen exposure, p53 alteration, and K-ras mutation in synchronous multiple primary lung carcinoma.
Carcinogen specificity in the activation of transforming genes by direct-acting alkylating agents.
Carcinogen-induced colon tumors in mice are chromosomally stable and are characterized by low-level microsatellite instability.
Carcinogen-induced liver tumours of Wistar rats: absence of activated ras genes and of N-rasC.
Carcinogenesis in MYH-associated polyposis follows a distinct genetic pathway.
Carcinogenesis of cancer of the papilla and ampulla: pathophysiological facts and molecular biological mechanisms.
Carcinogenic mechanisms of endometrial cancer: involvement of genetics and epigenetics.
Carcinogenicity studies of oxazepam in mice.
Carcinogenicity, DNA adduct formation and K-ras activation by 7H-dibenzo[c,g]carbazole in strain A/J mouse lung.
Carcinoma of the colon in childhood; report of 2 cases expressing p53 without K-ras mutation.
Carcinosarcoma colliding osteosarcoma of the pancreas: a rare case report of multiple clonal originated pancreatic tumors.
Case of Invasive Carcinoma Derived from Intraductal Papillary Mucinous Neoplasm Negative for GNAS Mutation.
Caveolin-1 is a novel regulator of K-RAS-dependent migration in colon carcinogenesis.
CD44 expression in colorectal adenomas is an early event occurring prior to K-ras and p53 gene mutation.
CD8+ T cells from a patient with colon carcinoma, specific for a mutant p21-Ras-derived peptide (Gly13-->Asp), are cytotoxic towards a carcinoma cell line harbouring the same mutation.
CDC4 mutations occur in a subset of colorectal cancers but are not predicted to cause loss of function and are not associated with chromosomal instability.
Cdc42 and Rac1 activity is reduced in human pheochromocytoma and correlates with FARP1 and ARHGEF1 expression.
Cdc42 and Rac1 are necessary for autotaxin-induced tumor cell motility in A2058 melanoma cells.
Cdc42 and Rac1 regulate late events in Salmonella typhimurium-induced interleukin-8 secretion from polarized epithelial cells.
Cdc42 expression in cervical cancer and its effects on cervical tumor invasion and migration.
CDC42 Gtpase Activation Affects Hela Cell DNA Repair and Proliferation Following UV Radiation-Induced Genotoxic Stress.
Cdc42 in oncogenic transformation, invasion, and tumorigenesis.
CDC42 inhibition suppresses progression of incipient intestinal tumors.
Cdc42 is highly expressed in colorectal adenocarcinoma and downregulates ID4 through an epigenetic mechanism.
Cdc42 is involved in basal cell carcinoma carcinogenesis.
Cdc42 mediates cancer cell chemotaxis in perineural invasion.
Cdc42 negatively regulates intrinsic migration of highly aggressive breast cancer cells.
Cdc42 promotes transendothelial migration of cancer cells through ?1 integrin.
Cdc42 regulates schwann cell radial sorting and myelin sheath folding through NF2/merlin-dependent and independent signaling.
Cdc42 Signaling Pathway Inhibition as a Therapeutic Target in Ras-Related Cancers.
Cdc42 subcellular relocation in response to VEGF/NRP1 engagement is associated with the poor prognosis of colorectal cancer.
Cdc42-mediated supracellular cytoskeleton induced cancer cell migration under low shear stress.
Cdc42: A Novel Regulator of Insulin Secretion and Diabetes-Associated Diseases.
Cdc42: an effector and regulator of ErbB1 as a strategic target in breast cancer therapy.
Cdc42: Role in Cancer Management.
CDK4/6 inhibition synergizes with inhibition of P21-Activated Kinases (PAKs) in lung cancer cell lines.
CDK5 is a major regulator of the tumor suppressor DLC1.
cDNA sequencing improves the detection of P53 missense mutations in colorectal cancer.
CDX-2 Expression in Primary Lung Adenocarcinoma.
CEA is the major PHA-L-reactive glycoprotein in colon carcinoma cell lines and tumors: relationship between K-ras activation and beta1-6 branching of N-linked carbohydrate on CEA.
Cell autonomous angiotensin II signaling controls the pleiotropic functions of oncogenic K-Ras.
Cell autonomous or systemic EGFR blockade alters the immune-environment in squamous cell carcinomas.
Cell cycle-dependent Rho GTPase activity dynamically regulates cancer cell motility and invasion in vivo.
Cell Division Cycle 42 plays a Cell type-Specific role in Lung Tumorigenesis.
Cell proliferation and drug resistance in hepatocellular carcinoma are modulated by Rho GTPase signals.
Cell proliferation and prevalence of ras gene mutations in 7,12-dimethylbenz(a)anthracene (DMBA)-induced rat mammary tumors.
Cell type-dependent HIF1 ?-mediated effects of hypoxia on proliferation, migration and metastatic potential of human tumor cells.
Cell-permeable CaaX-peptides affect K-Ras downstream signaling and promote cell death in cancer cells.
Cell-to-cell contact-mediated regulation of tumor behavior in the tumor microenvironment.
Cells lay their own tracks - optogenetic Cdc42 activation stimulates fibronectin deposition supporting directed migration.
Cellular and molecular biology of biliary tract cancers.
Cellular phenotypes of differentiated-type adenocarcinomas and precancerous lesions of the stomach are dependent on the genetic pathways.
Cellular protoonocogenes are infrequently amplified in untreated non-small cell lung cancer.
Cellular redox imbalance and changes of protein S-glutathionylation patterns are associated with senescence induced by oncogenic H-ras.
Cellular signaling for activation of Rho GTPase Cdc42.
Ceramide 1-phosphate regulates cell migration and invasion of human pancreatic cancer cells.
Cetuximab and circadian chronomodulated chemotherapy as salvage treatment for metastatic colorectal cancer (mCRC): safety, efficacy and improved secondary surgical resectability.
Cetuximab in the first-line treatment of K-ras wild-type metastatic colorectal cancer: the choice and schedule of fluoropyrimidine matters.
Cetuximab-based therapy for metastatic colorectal cancer: a meta-analysis of the effect of K-ras mutations.
cGMP-dependent protein kinase phosphorylates p21-activated kinase (Pak) 1, inhibiting Pak/Nck binding and stimulating Pak/vasodilator-stimulated phosphoprotein association.
Chalcones bearing a 3,4,5-trimethoxyphenyl motif are capable of selectively inhibiting oncogenic K-Ras signaling.
Changes in actin and E-cadherin expression induced by 5-aminolevulinic acid photodynamic therapy in normal and Ras-transfected human mammary cell lines.
Changes in cancer cell metabolism revealed by direct sample analysis with MALDI mass spectrometry.
Changes in protein expression after neoadjuvant use of aromatase inhibitors in primary breast cancer: a proteomic approach to search for potential biomarkers to predict response or resistance.
Characterisation of a subtype of colorectal cancer combining features of the suppressor and mild mutator pathways.
Characterisation of colorectal cancers showing hypermethylation at multiple CpG islands.
Characterization of a cdc42 protein inhibitor and its use as a molecular probe.
Characterization of a Dual Rac/Cdc42 Inhibitor MBQ-167 in Metastatic Cancer.
Characterization of EHop-016, a novel small molecule inhibitor of Rac GTPase.
Characterization of K-ras gene mutations in association with mucinous hypersecretion in intraductal papillary-mucinous neoplasms.
Characterization of pancreatic lesions from MT-tgfalpha, Ela-myc and MT-tgfalpha/Ela-myc single and double transgenic mice.
Characterization of primary breast carcinomas grown in three-dimensional cultures.
Characterization of the antitumor effects of the selective farnesyl protein transferase inhibitor R115777 in vivo and in vitro.
Characterization of the K-ras gene of the marsupial Monodelphis domestica.
Characterization of the mutations of the K-ras, p53, p16, and SMAD4 genes in 15 human pancreatic cancer cell lines.
CHD1L promotes hepatocellular carcinoma progression and metastasis in mice and is associated with these processes in human patients.
Chemical reverse transformation of CHO-K1 cells induces changes in expression of a candidate tumour suppressor and of a gene not previously characterised as transformation related.
Chemistry and biology of moverastins, inhibitors of cancer cell migration, produced by Aspergillus.
Chemopreventive effect of perillyl alcohol on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induced tumorigenesis in (C3H/HeJ X A/J)F1 mouse lung.
Chemopreventive efficacy of promising farnesyltransferase inhibitors.
Chemopreventive properties of trans-resveratrol are associated with inhibition of activation of the IkappaB kinase.
Chimaerins: GAPs that bridge diacylglycerol signalling and the small G-protein Rac.
Cholangiocarcinoma in primary sclerosing cholangitis: K-ras mutations and Tp53 dysfunction are implicated in the neoplastic development.
Cholangiocarcinoma Therapeutics: An Update.
Chromosomal changes and correspondingly altered proto-oncogene expression in human gliomas. Value of combined cytogenetic and molecular genetic analysis.
Chromosomal instability suppresses the growth of K-Ras-induced lung adenomas.
Chromosome aberrations and expression of ras and myc oncogenes in leiomyomas and a leiomyosarcoma of the uterus.
Chromosome aberrations [dup(1q)] in endometrial cancer: Gene analysis of 54 surgical specimens in Turkey.
Chromosome losses in tumorigenic revertants of EJ/ras-expressing somatic cell hybrids.
Chronic cadmium exposure in vitro induces cancer cell characteristics in human lung cells.
Chronic inhalation exposure to mainstream cigarette smoke increases lung and nasal tumor incidence in rats.
Chronic lymphocytic leukemia cells induce defective LFA-1-directed T cell motility by altering Rho GTPase signaling that is reversible with lenalidomide.
Chronic p27Kip1 Induction by Dexamethasone Causes Senescence Phenotype and Permanent Cell Cycle Blockade in Lung Adenocarcinoma Cells Over-expressing Glucocorticoid Receptor.
Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinoma by K-Ras oncogenes in adult mice.
Chronic ulcerative colitis and colorectal cancer.
CHUK/IKK-? loss in lung epithelial cells enhances NSCLC growth associated with HIF up-regulation.
Cigarette smoking and genetic alterations in sporadic colon carcinomas.
Cigarette smoking and K-ras mutations in pancreas, lung and colorectal adenocarcinomas: Etiopathogenic similarities, differences and paradoxes.
Cigarette smoking is strongly associated with mutation of the K-ras gene in patients with primary adenocarcinoma of the lung.
CircRNA hsa_circ_0030018 regulates the development of glioma via regulating the miR-1297/RAB21 axis.
Circular RNA circSIPA1L1 Contributes to Osteosarcoma Progression Through the miR-411-5p/RAB9A Signaling Pathway.
Circulating DNA for detection of gastric cancer.
Classic Ras Proteins Promote Proliferation and Survival via Distinct Phosphoproteome Alterations in Neurofibromin-Null Malignant Peripheral Nerve Sheath Tumor Cells.
Classification of advanced colorectal carcinomas by tumor edge morphology: evidence for different pathogenesis and significance of polypoid and nonpolypoid tumors.
Clear cell carcinoma of the pancreas: an adenocarcinoma with ductal phenotype.
Clinical and genetic analysis of noncancerous and cancerous biliary epithelium in patients with pancreaticobiliary maljunction.
Clinical detection of lung cancer progression markers.
Clinical impact of K-ras mutation analysis in EUS-guided FNA specimens from pancreatic masses.
Clinical implications of K-ras mutations in malignant epithelial tumors of the endometrium.
Clinical outcome of patients with non-small cell lung cancer receiving front-line chemotherapy according to EGFR and K-RAS mutation status.
Clinical relevance of cytoskeleton associated proteins for ovarian cancer.
Clinical relevance of H-RAS, K-RAS, and N-RAS mRNA expression in primary breast cancer patients.
Clinical relevance of the transcriptional signature regulated by CDC42 in colorectal cancer.
Clinical significance and the correlation of expression between Let-7 and K-ras in non-small cell lung cancer.
Clinical significance of cathepsin E in pancreatic juice in the diagnosis of pancreatic ductal adenocarcinoma.
Clinical significance of K-ras and c-erbB-2 mutations in pancreatic adenocarcinoma and chronic pancreatitis.
Clinical significance of K-Ras mutations in intraoperative tumor drainage blood from patients with colorectal carcinoma.
Clinical significance of K-ras oncogene activation in ampullary neoplasms.
Clinical significance of p53, K-ras and DCC gene alterations in the stage I-II colorectal cancers.
Clinical significance of ras oncogene activation in human lung cancer.
Clinical studies of antisense therapy in cancer.
Clinical usefulness of K-ras gene mutation detection and cytology in pancreatic juice in the diagnosis and screening of pancreatic cancer.
Clinical usefulness of K-RAS mutation detection in colorectal cancer and in surgical margins of the colon.
Clinical value of bile for the detection of mutant K-ras from colorectal liver metastases.
Clinical value of K-ras codon 12 analysis and endobiliary brush cytology for the diagnosis of malignant extrahepatic bile duct stenosis.
Clinical-pathological correlation of K-Ras mutation and ERK phosphorylation in colorectal cancer.
Clinico-pathological study of K-ras mutations in colorectal tumors in Saudi Arabia.
Clinico-Pathological Study of K-ras Mutations in Colorectal Tumors: A Single-Center Retrospective Study of 51 Patients in Madinah, Saudi Arabia.
Clinicopathologic analysis of k-ras, p53, and ERBB-2 gene alterations in pulmonary adenocarcinoma.
Clinicopathologic implications of MDM2, p53 and K-ras gene alterations in osteosarcomas: MDM2 amplification and p53 mutations found in progressive tumors.
Clinicopathologic significance of the K-ras gene codon 12 point mutation in stomach cancer. An analysis of 140 cases.
Clinicopathological and genetic characteristics of mucinous carcinomas in the colorectum.
Clinicopathological and prognostic features of surgically resected pathological stage I lung adenocarcinoma harboring epidermal growth factor receptor and K-ras mutation.
Clonal analysis of colorectal tumors using K-ras and p53 gene mutations as markers.
Clonal preservation of human pancreatic cell line derived from primary pancreatic adenocarcinoma.
Clonality and K-ras mutation analyses of epithelia in intraductal papillary mucinous tumor and mucinous cystic tumor of the pancreas.
Clonality, founder mutations, and field cancerization in human ulcerative colitis-associated neoplasia.
Cloning and characterization of a novel Rab-family gene, Rab36, within the region at 22q11.2 that is homozygously deleted in malignant rhabdoid tumors.
Cloning and characterization of a novel small monomeric GTPase, RasL10B, with tumor suppressor potential
Cloning and characterization of a novel small monomeric GTPase, RasL10B, with tumor suppressor potential.
Cloning and characterization of a novel splice variant of human Rab18 gene (RAB18)dagger.
CNF1-induced ubiquitylation and proteasome destruction of activated RhoA is impaired in Smurf1-/- cells.
CNF1-like deamidase domains: common Lego bricks among cancer-promoting immunomodulatory bacterial virulence factors.
Co-dependency of PKC? and K-Ras: inverse association with cytotoxic drug sensitivity in KRAS mutant lung cancer.
Co-mutation of p53, K-ras genes and accumulation of p53 protein and its correlation to clinicopathological features in rectal cancer.
Coamplification at lower denaturation temperature polymerase chain reaction enables selective identification of K-Ras mutations in formalin-fixed, paraffin-embedded tumor tissues without tumor-cell enrichment.
Codon 12 and codon 13 mutations at the K-ras gene induce different soft tissue sarcoma types in nude mice.
Codon 64 of K-ras gene mutation pattern in hepatocellular carcinomas induced by bleomycin and 1-nitropyrene in A/J mice.
Codon usage regulates human KRAS expression at both transcriptional and translational levels.
Coexistence of K-ras mutations and HPV infection in colon cancer.
Coexistence of somatic and germ-line mutations of APC gene in desmoid tumors from patients with familial adenomatous polyposis.
Collective cancer cell invasion requires RNA accumulation at the invasive front.
Collision tumor of cutaneous malignant melanoma and basal cell carcinoma.
Colon cancer: a civilization disorder.
Colorectal cancer screening by detection of altered human DNA in stool: feasibility of a multitarget assay panel.
Colorectal cancer: using blood samples and tumor tissue to detect K-ras mutations.
Colorectal carcinogenesis based on molecular biology of early colorectal cancer, with special reference to nonpolypoid (superficial) lesions.
Colorectal carcinogenesis.
Colorectal carcinogenesis: historical review.
Colorectal carcinogenesis: MSI-H versus MSI-L.
Combination of dihydroartemisinin and resveratrol effectively inhibits cancer cell migration via regulation of the DLC1/TCTP/Cdc42 pathway.
Combination of farnesyltransferase and Akt inhibitors is synergistic in breast cancer cells and causes significant breast tumor regression in ErbB2 transgenic mice.
Combination of immunoprecipitation (IP)-ATP_Glo kinase assay and melanogenesis for the assessment of potent and safe PAK1-blockers in cell culture.
Combination therapy with SCH58500 (p53 adenovirus) and cyclophosphamide in preclinical cancer models.
Combination therapy with vidaza and entinostat suppresses tumor growth and reprograms the epigenome in an orthotopic lung cancer model.
Combined cetuximab and trastuzumab are superior to gemcitabine in the treatment of human pancreatic carcinoma xenografts.
Combined erbB gene overexpression and decreased H-ras gene expression in human gliomas.
Combined Inactivation of MYC and K-Ras oncogenes reverses tumorigenesis in lung adenocarcinomas and lymphomas.
Combined silencing of K-ras and Akt2 oncogenes achieves synergistic effects in inhibiting pancreatic cancer cell growth in vitro and in vivo.
Combined subcarcinogenic benzo[a]pyrene and UVA synergistically caused high tumor incidence and mutations in H-ras gene, but not p53, in SKH-1 hairless mouse skin.
Comethylation of p16 and MGMT genes in colorectal carcinoma: correlation with clinicopathological features and prognostic value.
Comment on "Methylation patterns and K-ras mutations in tumor and paired serum of resected non-small-call lung cancer patients" (Cancer Letters 2003;193:207-216).
Common occurrence of APC and K-ras gene mutations in the spectrum of colitis-associated neoplasias.
Common occurrence of multiple K-RAS mutations in pancreatic cancers with associated precursor lesions and in biliary cancers.
Common Oncogene Mutations and Novel SND1-BRAF Transcript Fusion in Lung Adenocarcinoma from Never Smokers.
Common Telomere Changes during In Vivo Reprogramming and Early Stages of Tumorigenesis.
Comparative analysis of K-ras point mutation, telomerase activity, and p53 overexpression in pancreatic tumours.
Comparative analysis of mutations in the p53 and K-ras genes in pancreatic cancer.
Comparative analysis of p16/CDKN2, p53 and ras gene alterations in human non-small cell lung cancers, with and without associated pulmonary asbestosis.
Comparative analysis of p53 gene mutations and protein accumulation in human non-small-cell lung cancer.
Comparative effects of oncogenic mutations G12C, G12V, G13D, and Q61H on local conformations and dynamics of K-Ras.
Comparative immunohistochemical reactivity of monoclonal and polyclonal antibodies to H-ras p21 in normal and neoplastic tissues of rodents and humans.
Comparative Screening of K-ras Mutations in Colorectal Cancer and Lung Cancer Patients Using a Novel Real-Time PCR with ADx-K-ras Kit and Sanger DNA Sequencing.
Comparing the diagnostic accuracy of five common tumour biomarkers and CA19-9 for pancreatic cancer: a protocol for a network meta-analysis of diagnostic test accuracy.
Comparison of EGFR and K-RAS gene status between primary tumours and corresponding metastases in NSCLC.
Comparison of epigenetic and genetic alterations in mucinous cystic neoplasm and serous microcystic adenoma of pancreas.
Comparison of features of human lung cancer cell lines and their corresponding tumors.
Comparison of Ha-ras mutational spectra of N-methyldibenzo[c,g]carbazole and 7H-dibenzo[c,g]carbazole-induced mouse skin tumors.
Comparison of K-ras gene mutations in tumour and sputum DNA of patients with lung cancer.
Comparison of K-ras mutations in lung, colorectal and gastric cancer.
Comparison of K-ras point mutation distributions in intraductal papillary-mucinous tumors and ductal adenocarcinoma of the pancreas.
Comparison of Ki-67 antigen expression and K-ras mutation in lung tumours induced by urethane in mice.
Comparison of mutations in the p53 and K-ras genes in lung carcinomas from smoking and nonsmoking women.
Comparison of mutations of ras oncogene in human pancreatic exocrine and endocrine tumors.
Comparison of ras activation during epidermal carcinogenesis in vitro and in vivo.
Comparison of ras-responsive gene enhancers in pancreatic tumor cells that express either wild-type or mutant K-ras.
Compartmentalized Ras proteins transform NIH 3T3 cells with different efficiencies.
Complete Radiographic Response to Zoledronic Acid Therapy in a Patient With Bony Metastatic Urothelial Carcinoma: A Case Report.
Components of the Rb pathway are critical targets of UV mutagenesis in a murine melanoma model.
Comprehensive genomic analyses of a metastatic colon cancer to the lung by whole exome sequencing and gene expression analysis.
Comprehensive molecular analyses of lung adenocarcinoma with regard to the epidermal growth factor receptor, K-ras, MET, and hepatocyte growth factor status.
Comprehensive Mutation Analysis of PIK3CA, p14ARF, p16INK4a and p21Waf1/Cip1 Genes is Suggestive of a Non- Neoplastic Nature of Phenytoin Induced Gingival Overgrowth.
Computational and in vitro Pharmacodynamics Characterization of 1A-116 Rac1 Inhibitor: Relevance of Trp56 in Its Biological Activity.
Computational Modeling Reveals that Signaling Lipids Modulate the Orientation of K-Ras4A at the Membrane Reflecting Protein Topology.
Concomitant activation of MEK-1 and Rac-1 increases the proliferative potential of thyroid epithelial cells, without affecting their differentiation.
Concomitant K- and N-ras gene point mutations in clonal murine lymphoma.
Concurrent mutation in exons 1 and 2 of the K-ras oncogene in colorectal cancer.
Concurrent mutations of K-ras oncogene at codons 12 and 22 in colon cancer.
Conditional expression of mutated K-ras accelerates intestinal tumorigenesis in Msh2-deficient mice.
Conditional mouse lung cancer models using adenoviral or lentiviral delivery of Cre recombinase.
Conformational SERS Classification of K-Ras Point Mutations for Cancer Diagnostics.
Conformational transformation of switch domains in GDP/K-Ras induced by G13 mutants: An investigation through Gaussian accelerated molecular dynamics simulations and principal component analysis.
Constitutively active Harvey Ras confers resistance to epidermal growth factor receptor-targeted therapy with cetuximab and gefitinib.
Contextual extracellular cues promote tumor cell EMT and metastasis by regulating miR-200 family expression.
Contextual inhibition of fatty acid synthesis by metformin involves glucose-derived acetyl-CoA and cholesterol in pancreatic tumor cells.
Contribution of dichloroacetate and trichloroacetate to liver tumor induction in mice by trichloroethylene.
Contribution of epithelial-to-mesenchymal transition and cancer stem cells to pancreatic cancer progression.
Control by the endogenous cannabinoid system of ras oncogene-dependent tumor growth.
Control of colorectal metastasis formation by K-Ras.
Control of Rho GTPase function by BAR-domains.
Converged Rab37/IL-6 trafficking and STAT3/PD-1 transcription axes elicit an immunosuppressive lung tumor microenvironment.
Conversion to complete resection with mFOLFOX6 with bevacizumab or cetuximab based on K-ras status for unresectable colorectal liver metastasis (BECK study).
Conversion to complete resection with mFOLFOX6 with bevacizumab or cetuximab based on K-RAS status for unresectable colorectal liver metastasis (BECK study): Long-term results of survival.
Cooperative induction of rat mammary cancer by radiation and 1-methyl-1-nitrosourea via the oncogenic pathways involving c-Myc activation and H-ras mutation.
Coordinated Regulation of Intracellular Fascin Distribution Governs Tumor Microvesicle Release and Invasive Cell Capacity.
COPD-Type lung inflammation promotes K-ras mutant lung cancer through epithelial HIF-1? mediated tumor angiogenesis and proliferation.
Coping with strong translational noncrystallographic symmetry and extreme anisotropy in molecular replacement with Phaser: human Rab27a.
Copy number alterations of chromosomal regions enclosing protein tyrosine phosphatase receptor-like genes in colorectal cancer.
Copy number of cancer genes predict tumor grade and survival of pancreatic cancer patients.
Correction: Metformin impairs Rho GTPase signaling to induce apoptosis in neuroblastoma cells and inhibits growth of tumors in the xenograft mouse model of neuroblastoma.
Correction: Targeting the ?4-?5 dimerization interface of K-RAS inhibits tumor formation in vivo.
Correlated flow cytometric analysis of H-ras p21 and nuclear DNA in multiple myeloma.
Correlation between Bcl-2 overexpression and H-ras mutation in naturally occurring hepatocellular proliferative lesions of the B6C3F1 mouse.
Correlation between K-ras gene mutation and prognosis of patients with nonsmall cell lung carcinoma.
Correlation between microsatellite instability and metachronous disease recurrence after endoscopic mucosal resection in patients with early stage gastric carcinoma.
Correlation Between RAB27B and p53 Expression and Overall Survival in Pancreatic Cancer.
Correlation of cellular differentiation in human colorectal carcinoma and adenoma cell lines with metabolite profiles determined by 1H magnetic resonance spectroscopy.
Correlation of COX-2 and K-ras expression to clinical outcome in gastric cancer.
CpG island methylation in sporadic colorectal cancers and its relationship to microsatellite instability.
CpG island promoter hypermethylation of the Ras-effector gene NORE1A occurs in the context of a wild-type K-ras in lung cancer.
Critical role of PTEN for development and progression of nerve sheath tumors in neurofibromatosis type 1.
Cronkhite-Canada syndrome containing colon cancer and serrated adenoma lesions.
Crosstalk between ERK, AKT, and cell survival.
Crosstalk between Pten and Ras signaling pathways in tumor development.
Crystal Structure of a Human K-Ras G12D Mutant in Complex with GDP and the Cyclic Inhibitory Peptide KRpep-2d.
CSE1L modulates Ras-induced cancer cell invasion: correlation of K-Ras mutation and CSE1L expression in colorectal cancer progression.
CtBP-a targetable dependency for tumor-initiating cell activity and metastasis in pancreatic adenocarcinoma.
CtBP2 Promotes Human Cancer Cell Migration by Transcriptional Activation of Tiam1.
Cucurbit [7] uril encapsulated cisplatin overcomes resistance to cisplatin induced by Rab25 overexpression in an intraperitoneal ovarian cancer model.
Cucurbitacin B Alters the Expression of Tumor-Related Genes by Epigenetic Modifications in NSCLC and Inhibits NNK-Induced Lung Tumorigenesis.
Curative resection of hilar cholangiocarcinoma in a 25-year-old woman: report of a case.
Current Chemotherapy and Potential New Targets in Uterine Leiomyosarcoma.
Current treatment strategies for pancreatic cancer in the elderly.
CXCL12 promotes human ovarian cancer cell invasion through suppressing ARHGAP10 expression.
CXCR4 regulates the early extravasation of metastatic tumor cells in vivo.
Cyclic AMP regulates the migration and invasion potential of human pancreatic cancer cells.
Cyclin D1 harboring the T286I mutation promotes oncogenic activation in endometrial cancer.
Cyclin D1 over-expression correlates with beta-catenin activation, but not with H-ras mutations, and phosphorylation of Akt, GSK3 beta and ERK1/2 in mouse hepatic carcinogenesis.
Cyclin D1 overexpression in rat two-stage bladder carcinogenesis and its relationship with oncogenes, tumor suppressor genes, and cell proliferation.
Cyclooxygenase-2 expression in human pancreatic adenocarcinomas.
Cyclooxygenase-2 overexpression is related to polypoid growth and K-ras gene mutation in T1 colorectal carcinomas.
Cyclophilin D counteracts P53-mediated growth arrest and promotes Ras tumorigenesis.
Cytogenetic alterations in eight mammary tumors and tumor-suppressor gene p53 mutation in one mammary tumor from dogs.
Cytogenetic, ras, and p53: studies in cases of canine neoplasms (hemangiopericytoma, mastocytoma, histiocytoma, chloroma).
Cytokinesis failure due to derailed integrin traffic induces aneuploidy and oncogenic transformation in vitro and in vivo.
Cytotoxic CD4+ and CD8+ T lymphocytes, generated by mutant p21-ras (12Val) peptide vaccination of a patient, recognize 12Val-dependent nested epitopes present within the vaccine peptide and kill autologous tumour cells carrying this mutation.
Cytotoxicity induced by exposure to natural and synthetic tremolite asbestos: An in vitro pilot study.
Dacarbazine-induced immunogenicity of a murine leukemia is attenuated in cells transfected with mutated K-ras gene.
De novo CD5-positive and Richter's syndrome-associated diffuse large B cell lymphomas are genotypically distinct.
Death effector domain protein PEA-15 potentiates Ras activation of extracellular signal receptor-activated kinase by an adhesion-independent mechanism.
Decrease in K-ras p21 and increase in Raf1 and activated Erk 1 and 2 in murine lung tumors initiated by N-nitrosodimethylamine and promoted by 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Decreased c-kit function inhibits enhanced skin carcinogenesis in c-Ha-ras protooncogene transgenic mice.
Decreased expression of miR-410-3p correlates with poor prognosis and tumorigenesis in human glioma.
Decreased expression of Rab27A and Rab27B correlates with metastasis and poor prognosis in colorectal cancer.
Decreased GTPase activity of K-ras mutants deriving from human functional adrenocortical tumours.
Deficiencies in mouse Myh and Ogg1 result in tumor predisposition and G to T mutations in codon 12 of the K-ras oncogene in lung tumors.
Deficiency of a potential 3p21.3 tumor suppressor gene UBE1L (UBA7) does not accelerate lung cancer development in K-ras(LA2) mice.
Degradation of activated K-Ras orthologue via K-Ras-specific lysine residues is required for cytokinesis.
Degradation of endothelial cell matrix collagen is correlated with induction of stromelysin by an activated ras oncogene.
Dehydro-alpha-lapachone, a plant product with antivascular activity.
Dehydrotrametenolic acid selectively inhibits the growth of H-ras transformed rat2 cells and induces apoptosis through caspase-3 pathway.
Deleted in liver cancer 1 (DLC1) negatively regulates Rho/ROCK/MLC pathway in hepatocellular carcinoma.
Deleted in liver cancer-1 (DLC-1): a tumor suppressor not just for liver.
Deletion of cyclooxygenase-2 inhibits K-ras-induced lung carcinogenesis.
Deletion of Lactate Dehydrogenase-A in Myeloid Cells Triggers Antitumor Immunity.
Deletion of Rap1b, but not Rap1a or Epac1, Reduces Protein Kinase A-Mediated Thyroid Cancer.
Denaturing gradient gel electrophoresis (DGGE) assay for K-ras and N-ras genes: detection of K-ras point mutations in human lung tumour DNA.
DENND2B activates Rab13 at the leading edge of migrating cells and promotes metastatic behavior.
DEP domain containing 1 predicts prognosis of hepatocellular carcinoma patients and regulates tumor proliferation and metastasis.
Depletion of K-Ras promotes proteasome degradation of survivin.
Deregulated matriptase causes ras-independent multistage carcinogenesis and promotes ras-mediated malignant transformation.
Deregulation of miR-146a expression in a mouse model of pancreatic cancer affecting EGFR signaling.
Deregulation of Rab and Rab effector genes in bladder cancer.
Deregulation of Rho GTPases in cancer.
Design and in vivo analysis of potent non-thiol inhibitors of farnesyl protein transferase.
Designed diagnostic restriction fragment length polymorphisms for the detection of point mutations in ras oncogenes.
Detecting colorectal cancer in stool with the use of multiple genetic targets.
Detecting K-ras mutations in stool from fecal occult blood test cards in multiphasic screening for colorectal cancer.
Detection and characterization of oncogene mutations in preneoplastic and early neoplastic lesions.
Detection and Characterization of Oncogene Mutations in Preneoplastic and Early Neoplastic Lesions.
Detection and clinical correlations of ras gene mutations in human ovarian tumors.
Detection and cloning of potent transforming gene(s) from chewing tobacco-related human oral carcinomas.
Detection by denaturant gradient gel electrophoresis of tumor-specific mutations in biopsies and relative bronchoalveolar lavage fluid from resectable non-small cell lung cancer.
Detection of a rare point mutation at codon 59 and relatively high incidence of H-ras mutation in Indian oral cancer.
Detection of activated K-ras in non-small cell lung cancer by membrane array: a comparison with direct sequencing.
Detection of activated proto-oncogenes in N-nitrosodiethylamine-induced liver tumors: a comparison between B6C3F1 mice and Fischer 344 rats.
Detection of altered H-ras proteins in human tumors using western blot analysis.
Detection of APC and k-ras mutations in the serum of patients with colorectal cancer.
Detection of circulating cancer cells with K-ras oncogene using membrane array.
Detection of circulating tumor cells in colorectal cancer by immunobead-PCR is a sensitive prognostic marker for relapse of disease.
Detection of codon 12 K-ras mutations in non-neoplastic mucosa from bronchial carina in patients with lung adenocarcinomas.
Detection of codon 12 mutation in the K-ras oncogene in pancreatic tumors.
Detection of codon 12 point mutations of the K-ras gene from mouse lung adenocarcinoma by 'enriched' PCR.
Detection of codon 61 point mutations of the K-ras gene in lung and colorectal cancers by enriched PCR.
Detection of dibenzo[a,l]pyrene-induced H-ras codon 61 mutant genes in preneoplastic SENCAR mouse skin using a new PCR-RFLP method.
Detection of DNA point mutations with DNA mismatch repair enzymes.
Detection of high incidence of K-ras oncogenes during human colon tumorigenesis.
Detection of human papilloma virus (HPV) and K-ras mutations in human lung carcinomas.
Detection of human papillomavirus types 16 and 18 in human neoplastic endometrium: lack of correlation with established prognostic factors.
Detection of infrequent and multiple K-ras mutations in human tumors and tumor-adjacent tissues.
Detection of isolated tumor cells by polymerase chain reaction-restriction fragment length polymorphism for K-ras mutations in tissue samples of 199 colorectal cancer patients.
Detection of K-ras and p53 gene mutations in pancreatic juice for the diagnosis of intraductal papillary mucinous tumors.
Detection of K-ras and p53 mutations in bronchoscopically obtained malignant and non-malignant tissue from patients with non-small cell lung cancer.
Detection of K-ras and p53 mutations in sputum samples of lung cancer patients using laser capture microdissection microscope and mutation analysis.
Detection of K-ras exon 1 mutations by constant denaturant capillary electrophoresis.
Detection of K-ras gene mutations at codon 12 in the pancreatic juice of patients with intraductal papillary mucinous tumors of the pancreas.
Detection of K-ras gene mutations in feces by magnetic nanoprobe in patients with pancreatic cancer: A preliminary study.
Detection of K-ras gene mutations in plasma DNA of patients with pancreatic adenocarcinoma: correlation with clinicopathological features.
Detection of K-ras mutation in a patient with multiple tumors.
Detection of K-ras mutation in colonic effluent samples from patients without evidence of colorectal carcinoma.
Detection of k-ras mutation in normal and malignant colonic tissues by an enriched PCR method.
Detection of K-ras mutations by denaturing gradient gel electrophoresis (DGGE): a study on pancreatic cancer.
Detection of K-ras mutations in azoxymethane-induced aberrant crypt foci in mice using LNA -mediated real-time PCR clamping and mutant-specific probes.
Detection of K-ras mutations in DNAs isolated from feces of patients with colorectal tumors by mutant-allele-specific amplification (MASA).
Detection of K-ras mutations in lung carcinomas: relationship to prognosis.
Detection of K-ras mutations in mucinous pancreatic duct hyperplasia from a patient with a family history of pancreatic carcinoma.
Detection of k-ras mutations in nonsmall cell lung-carcinoma.
Detection of K-ras mutations in pancreatic and hepatic neoplasms by non-isotopic mismatched polymerase chain reaction.
Detection of K-ras mutations in resected primary leiomyosarcoma.
Detection of K-ras mutations in stools of patients with colorectal cancer by mutant-enriched PCR.
Detection of K-ras mutations in the plasma DNA of pancreatic cancer patients.
Detection of K-ras mutations in the stool of patients with pancreatic adenocarcinoma and pancreatic ductal hyperplasia.
Detection of K-Ras mutations in tumour samples of patients with non-small cell lung cancer using PNA-mediated PCR clamping.
Detection of K-ras oncogene from the human genomic DNA using ultrasonication and a quantum dots-based microfluidic chip.
Detection of K-ras point mutation at codon 12 in pancreatic diseases: a study in a Brazilian casuistic.
Detection of K-ras point mutation at codon 12 in pure pancreatic juice collected 3 years and 6 months before the clinical diagnosis of pancreatic cancer.
Detection of K-ras point mutation by enriched PCR-colorimetric plate assay.
Detection of K-ras point mutations at codon 12 in pure pancreatic juice for the diagnosis of pancreatic cancer by PCR-RFLP analysis.
Detection of k-ras point mutations in codons 12 and 13 in non-small cell lung cancers.
Detection of K-ras point mutations in mesenteric venous blood from colorectal cancer patients by enriched polymerase chain reaction and single-strand conformation polymorphism analysis.
Detection of K-ras point mutations in sputum from patients with adenocarcinoma of the lung by point-EXACCT.
Detection of low-fraction K-ras mutations in primary lung tumors using a sensitive method.
Detection of mutant K-ras DNA in plasma or serum of patients with colorectal cancer.
Detection of mutant K-ras in dissected paraaortic lymph nodes of patients with pancreatic adenocarcinoma.
Detection of mutant k-ras sequences in the urine of cancer patients.
Detection of mutations of p53 tumor suppressor gene in pancreatic juice and its application to diagnosis of patients with pancreatic cancer: comparison with K-ras mutation.
Detection of occult metastases in sentinel lymph nodes from colon cancer patients by K-ras mutation peptide nucleic acid clamp PCR.
Detection of oncogene mutation from neoplastic colonic cells exfoliated in feces.
Detection of oncogenes in the diagnosis of cancers with active oncogenic signaling.
Detection of p53 and K-ras mutations in sputum of individuals exposed to smoky coal emissions in Xuan Wei County, China.
Detection of pancreatic carcinoma: diagnostic value of K-ras mutations in circulating DNA from serum.
Detection of point mutation in K-ras oncogene at codon 12 in pancreatic diseases.
Detection of point mutations in K-ras gene at codon 12 in bile from percutaneous transhepatic choledochal drainage tubes for diagnosis of biliary strictures.
Detection of point mutations in the K-ras oncogene at codon 12 in pure pancreatic juice for diagnosis of pancreatic carcinoma.
Detection of rare circulating human colon tumor cells in a nude mouse xenograft model.
Detection of ras gene mutations in peripheral blood of carcinoma patients using CD45 immunomagnetic separation and nested mutant allele specific amplification.
Detection of ras oncogene point mutations and simultaneous proliferative fraction estimation in gallbladder cancer.
Detection of somatic DNA alterations in azoxymethane-induced F344 rat colon tumors by random amplified polymorphic DNA analysis.
Detection of the mutated K-Ras biomarker in colorectal carcinoma.
Detection of transforming oncogenes in rat colon tumors induced by direct perfusion with N-methyl-N-nitrosourea.
Detection of tumor cells in blood using CD45 magnetic cell separation followed by nested mutant allele-specific amplification of p53 and K-ras genes in patients with colorectal cancer.
Detection of tumor DNA in serum of colorectal cancer patients.
Detection of tumour DNA in serum of colorectal cancer patients.
Detection of two novel mutations and relatively high incidence of H-RAS mutations in Vietnamese oral cancer.
Detection of UV-induced K-ras codon 12 mutation by PCR and differential dot-blot hybridization in cells from Down syndrome and Cockayne syndrome.
Determinants of recurrence after intended curative resection for colorectal cancer.
Determination of microsatellite instability, p53 and K-RAS mutations in hepatic metastases from patients with colorectal cancer: relationship with response to 5-fluorouracil and survival.
Development and characterization of a cytokine-secreting pancreatic adenocarcinoma vaccine from primary tumors for use in clinical trials.
Development and utilization of the rat lymphocyte hprt mutation assay.
Development of a rapid and practical mutation screening assay for human lung adenocarcinoma.
Development of colonic neoplasia in p53 deficient mice with experimental colitis induced by dextran sulphate sodium.
Development of EHop-016: a small molecule inhibitor of Rac.
Development of human cell models for assessing the carcinogenic potential of chemicals.
Diabetes and oral oncogenesis.
Diacylglycerol kinase ? controls RCP-dependent integrin trafficking to promote invasive migration.
Diagnosis of pancreatic cancer by cytology and measurement of oncogene and tumor markers in pure pancreatic juice aspirated by endoscopy.
Diagnosis of pancreatic cancer by K-ras point mutation and cytology of pancreatic juice.
Diagnosis of pancreatico-biliary malignancy: detection of gene mutations in plasma and stool.
Diagnostic and prognostic value of incidence of K-ras codon 12 mutations in resected distal bile duct carcinoma.
Diagnostic procedures for paraffin-embedded tissues analysis in pharmacogenomic studies.
Diagnostic utility of K-ras mutational analysis on bile obtained by endoscopic retrograde cholangiopancreatography.
Diagnostic utility of K-ras mutations in fine-needle aspirates of pancreatic masses.
Diagnostic value of K-ras mutation analysis for pancreaticobiliary cytology specimens with indeterminate diagnosis.
Dietary folate and APC mutations in sporadic colorectal cancer.
Dietary folate intake and k-ras mutations in sporadic colon and rectal cancer in The Netherlands Cohort Study.
Dietary phytate lowers K-ras mutational frequency, decreases DNA-adduct and hydroxyl radical formation in azoxymethane-induced colon cancer.
Dietary supplementation of lutein reduces colon carcinogenesis in DMH-treated rats by modulating K-ras, PKB, and ?-catenin proteins.
Dietary, lifestyle and clinicopathological factors associated with BRAF and K-ras mutations arising in distinct subsets of colorectal cancers in the EPIC Norfolk study.
Differences between KC and KPC pancreatic ductal adenocarcinoma mice models, in terms of their modeling biology and their clinical relevance.
Differences in carcinogenesis by the length of carcinogen exposure period in rat colon.
Differences in K-ras and p53 gene mutations among pancreatic adenocarcinomas associated with regional environmental pollution.
Differences in mucus and K-ras mutation in relation to phenotypes of tumors of the papilla of vater.
Differences in the frequencies of K-ras c12-13 genotypes by gender and pathologic phenotypes in colorectal tumors measured using the allele discrimination method.
Differences in the histological findings, phenotypic marker expressions and genetic alterations between adenocarcinoma of the gastric cardia and distal stomach.
Different effects of point mutations within the B-Raf glycine-rich loop in colorectal tumors on mitogen-activated protein/extracellular signal-regulated kinase kinase/extracellular signal-regulated kinase and nuclear factor kappaB pathway and cellular transformation.
Different genetic alterations in rat forestomach tumors induced by genotoxic and non-genotoxic carcinogens.
Different genetic features associated with colon and rectal carcinogenesis.
Different genetic pathways to proximal and distal colorectal cancer influenced by sex-related factors.
Different pattern of metastasis in liver implanted pancreatic cancer between young and old Syrian golden hamsters.
Different types of K-Ras mutations could affect drug sensitivity and tumour behaviour in non-small-cell lung cancer.
Differential (Ha-, K- and N-) ras p21 expression in benign and malignant human thyroid tumors: an immunohistochemical study.
Differential activation of ERK and JNK mitogen-activated protein kinases by Raf-1 and MEKK.
Differential colorectal carcinogenesis: Molecular basis and clinical relevance.
Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon.
Differential expression and activation of epidermal growth factor receptor 1 (EGFR1), ERK, AKT, STAT3, and TWIST1 in nonsmall cell lung cancer (NSCLC).
Differential expression and mutation of the ras family genes in human breast cancer.
Differential expression of cell cycle regulators in phenotypic variants of transgenically induced bladder tumors: implications for tumor behavior.
Differential Expression of IL-17, 22 and 23 in the Progression of Colorectal Cancer in Patients with K-ras Mutation: Ras Signal Inhibition and Crosstalk with GM-CSF and IFN-?.
Differential expression of miR-195 in esophageal squamous cell carcinoma and miR-195 expression inhibits tumor cell proliferation and invasion by targeting of Cdc42.
Differential expression of the H-ras mutated and normal alleles in rabbit DMBA-induced keratoacanthomas.
Differential oncogenic Ras signaling and senescence in tumor cells.
Differential Rac1 signalling by guanine nucleotide exchange factors implicates FLII in regulating Rac1-driven cell migration.
Differential roles of STAT3 in the initiation and growth of lung cancer.
Differential sensitivity of normal and H-ras oncogene-transformed rat kidney epithelial cells to okadaic acid-induced apoptosis.
Differentiation of tumour-promoting stromal myofibroblasts by cancer exosomes.
Differing deregulation of EGFR and downstream proteins in primary colorectal cancer and related metastatic sites may be clinically relevant.
Differing molecular pathology of pancreatic adenocarcinoma in Egyptian and United States patients.
Dihydrosanguinarine suppresses pancreatic cancer cells via regulation of mut-p53/WT-p53 and the Ras/Raf/Mek/Erk pathway.
DIRAS3 (ARHI) Blocks RAS/MAPK Signaling by Binding Directly to RAS and Disrupting RAS Clusters.
Direct evidence for the contribution of activated N-ras and K-ras oncogenes to increased intrinsic radiation resistance in human tumor cell lines.
Discordance between K-ras mutations in bone marrow micrometastases and the primary tumor in colorectal cancer.
Discordance of Mutation Statuses of Epidermal Growth Factor Receptor and K-ras between Primary Adenocarcinoma of Lung and Brain Metastasis.
Discovery and characterization of small molecule Rac1 inhibitors.
Discovery of (R)-7-cyano-2,3,4, 5-tetrahydro-1-(1H-imidazol-4-ylmethyl)-3- (phenylmethyl)-4-(2-thienylsulfonyl)-1H-1,4-benzodiazepine (BMS-214662), a farnesyltransferase inhibitor with potent preclinical antitumor activity.
Discovery of a Direct Ras Inhibitor by Screening a Combinatorial Library of Cell-Permeable Bicyclic Peptides.
Discovery of High-Affinity Noncovalent Allosteric KRAS Inhibitors That Disrupt Effector Binding.
Discrepancies between the K-ras mutational status of primary colorectal cancers and corresponding liver metastases are found in codon 13.
Disruption of actin filaments and suppression of pancreatic cancer cell viability and migration following treatment with polyisoprenylated cysteinyl amides.
Disruption of redox homeostasis for combinatorial drug efficacy in K-Ras tumors as revealed by metabolic connectivity profiling.
Dissecting the different biological effects of oncogenic Ras isoforms in cancer cell lines: Could stimulation of oxidative stress be the one more weapon of H-Ras?: Regulation of oxidative stress and Ras biological effects.
Disseminated colorectal tumor cells in organs prone to metastasis detected by new double enriched nested-PCR in comparison with recognized assays.
Dissociation mechanism of GDP from Cdc42 via DOCK9 revealed by molecular dynamics simulations.
Distinct genetic profiles in colorectal tumors with or without the CpG island methylator phenotype.
Distinct K-ras mutation pattern characterizes signet ring cell colorectal carcinoma.
Distinction of low grade from high grade human ovarian carcinomas on the basis of losses of heterozygosity on chromosomes 3, 6, and 11 and HER-2/neu gene amplification.
Distinctive molecular genetic alterations in sporadic and familial adenomatous polyposis-associated pancreatoblastomas : frequent alterations in the APC/beta-catenin pathway and chromosome 11p.
Distribution of genetic variants in preneoplastic areas of colorectal tumours.
Distribution of p53 and K-ras mutations in human lung cancer tissues.
Divergent in vitro/in vivo responses to drug treatments of highly aggressive NIH-Ras cancer cells: a PET imaging and metabolomics-mass-spectrometry study.
Divergent Roles of PAX2 in the Etiology and Progression of Ovarian Cancer.
Diverse roles of tissue factor-expressing cell subsets in tumor progression.
Diverse subpopulations of vesicles secreted by different intracellular mechanisms are present in exosome preparations obtained by differential ultracentrifugation.
Diverse tumorigenic pathways in ovarian serous carcinoma.
DLC-1 suppresses non-small cell lung cancer growth and invasion by RhoGAP-dependent and independent mechanisms.
DLC1 is a chromosome 8p tumor suppressor whose loss promotes hepatocellular carcinoma.
DLC1 is the principal biologically-relevant down-regulated DLC family member in several cancers.
DLC1 is unlikely to be a primary target for deletions on chromosome arm 8p22 in head and neck squamous cell carcinoma.
DLC1 suppresses NF-?B activity in prostate cancer cells due to its stabilizing effect on adherens junctions.
DLC2 modulates angiogenic responses in vascular endothelial cells by regulating cell attachment and migration.
DLC2 operates as a tumor suppressor gene in breast cancer via the RhoGTPase pathway.
DNA adduct measurements, cell proliferation and tumor mutation induction in relation to tumor formation in B6C3F1 mice fed coal tar or benzo[a]pyrene.
DNA adducts and p53 mutations in a patient with aristolochic acid-associated nephropathy.
DNA adducts, genetic polymorphisms, and K-ras mutation in human pancreatic cancer.
DNA alkylation and repair in the large bowel: animal and human studies.
DNA alterations in sporadic colorectal tumors do not correlate with tumor staging diagnosed by the TNM system.
DNA aneuploidy in morphologically normal colons from patients with colon cancer.
DNA content and other factors associated with ten-year survival after resection of pancreatic carcinoma.
DNA hypermethylation status of multiple genes in prostate adenocarcinomas.
DNA methylation adduct formation and H-ras gene mutations in progression of N-butyl-N-(4-hydroxybutyl)nitrosamine-induced bladder tumors caused by a single exposure to N-methyl-N-nitrosourea.
DNA methylation of coding and non-coding regions of the human H-RAS gene in normal and tumor tissues.
DNA methylation of the CYP1A1 enhancer is associated with smoking-induced genetic alterations in human lung.
DNA methylation patterns in adenomas from FAP, multiple adenoma and sporadic colorectal carcinoma patients.
DNA repair: counteragent in mutagenesis and carcinogenesis-- accomplice in cancer therapy resistance.
Do molecular markers predict survival in non-small-cell lung cancer?
Doc-2/hDab2 expression is up-regulated in primary pancreatic cancer but reduced in metastasis.
DOCK10-mediated Cdc42 activation is necessary for amoeboid invasion of melanoma cells.
Does early polypoid colorectal cancer with depression have a pathway other than adenoma-carcinoma sequence?
Dominant negative Rac1 attenuates paclitaxel-induced apoptosis in human melanoma cells through upregulation of heat shock protein 27: a functional proteomic analysis.
Dormant Wnt-initiated mammary cancer can participate in reconstituting functional mammary glands.
Dosage and allelic restriction fragment studies and PCR analysis of the H-ras locus in giant cell tumor of bone.
Dose-dependent ras mutation spectra in N-nitrosodiethylamine induced mouse liver tumors and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induced mouse lung tumors.
Double cancer of gall bladder and bile duct not associated with anomalous junction of the pancreaticobiliary duct system.
Down-regulation of let-7 microRNA increased K-ras expression in lung damage induced by radon.
Downregulated expression of ARHGAP10 correlates with advanced stage and high Ki-67 index in breast cancer.
Downregulation of PAR-4, a pro-apoptotic gene, in pancreatic tumors harboring K-ras mutation.
Downregulation of Rab23 in Prostate Cancer Inhibits Tumor Growth In Vitro and In Vivo.
Downregulation of Rab27A contributes to metformin-induced suppression of breast cancer stem cells.
Downregulation of Ral GTPase-activating protein promotes tumor invasion and metastasis of bladder cancer.
Downregulation of RECK by promoter methylation correlates with lymph node metastasis in non-small cell lung cancer.
Downregulation of survivin and aurora a by histone deacetylase and RAS inhibitors: A new drug combination for cancer therapy.
Downregulation of the long noncoding RNA SNHG1 inhibits tumor cell migration and invasion by sponging miR-195 through targeting Cdc42 in oesophageal cancer.
Downregulation of the Novel Tumor Suppressor DIRAS1 Predicts Poor Prognosis in Esophageal Squamous Cell Carcinoma.
Dr. Neri et al.: Prognostic role of K-ras mutations in non-small cell lung cancer: Still an issue for open debate.
DRoP: a water analysis program identifies Ras-GTP-specific pathway of communication between membrane-interacting regions and the active site.
Drugging K-RasG12C through covalent inhibitors: Mission possible?
Drugging the Small GTPase Pathways in Cancer Treatment: Promises and Challenges.
Dual inhibition of the epidermal growth factor receptor with cetuximab, an IgG1 monoclonal antibody, and gefitinib, a tyrosine kinase inhibitor, in patients with refractory non-small cell lung cancer (NSCLC): a phase I study.
Ductal and acinar differentiation in pancreatic endocrine tumors.
Ductal lesions in patients with chronic pancreatitis show K-ras mutations in a frequency similar to that in the normal pancreas and lack nuclear immunoreactivity for p53.
Ductal neoplasia of the pancreas: nosologic, clinicopathologic, and biologic aspects.
Duodenal cancer in a patient with Peutz-Jeghers syndrome: molecular analysis.
Dynamin 2 mediates PDGFR?-SHP-2-promoted glioblastoma growth and invasion.
Dysregulation of Rab37-Mediated Cross-talk between Cancer Cells and Endothelial Cells via Thrombospondin-1 Promotes Tumor Neovasculature and Metastasis.
Dysregulation of Rho GTPases in Human Cancers.
Early detection and prevention of lung cancer.
Early detection of cancer-associated gene alterations in DNA isolated from rat feces during intestinal tumor-induction with 1,2-dimethylhydrazine.
Early onset of colorectal cancer in a 13-year-old girl with Lynch syndrome.
Early-onset colorectal cancer: A distinct entity with unique genetic features.
Ectopic Thyroid Tissue in the Adrenal Gland: Report of a Case.
Effect of 8-oxoguanine glycosylase deficiency on aflatoxin B1 tumourigenicity in mice.
Effect of an epidermal growth factor receptor inhibitor in mouse models of lung cancer.
Effect of early vs. late administration of 4-hydroxyphenylretinamide (4-HPR) on N-methyl-N-nitrosourea (MNU)-induced mammary tumorigenesis.
Effect of farnesyltransferase inhibitor FTI-276 on established lung adenomas from A/J mice induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.
Effect of K-ras mutation on morphogenesis of colorectal adenomas and early cancers: relationship to distribution of proliferating cells.
Effect of novel CAAX peptidomimetic farnesyltransferase inhibitor on angiogenesis in vitro and in vivo.
Effect of polyamine oxidase inhibition on the colonic malignant transformation process induced by 1,2-dimethylhydrazine.
Effect of promoter and intron 2 polymorphisms on murine lung K-ras gene expression.
Effect of Ras-guanine nucleotide release factor 1-mediated H-Ras/ERK signaling pathway on glioma.
Effect of the secretory small GTPase Rab27B on breast cancer growth, invasion, and metastasis.
Effective panitumumab treatment in patients with heavily pre-treated metastatic colorectal cancer: a case series.
Effects of 5'-azacytidine and alendronate on a hepatocellular carcinoma cell line: a proteomics perspective.
Effects of antisense oligonucleotides targeting k-ras expression in pancreatic-cancer cell-lines.
Effects of asbestiform antigorite on human alveolar epithelial A549 cells: A morphological and immunohistochemical study.
Effects of CDC42 on the proliferation and invasion of gastric cancer cells.
Effects of Rab27A and Rab27B on Invasion, Proliferation, Apoptosis, and Chemoresistance in Human Pancreatic Cancer Cells.
Effects of silencing Rab27a gene on biological characteristics and chemosensitivity of non-small cell lung cancer.
Effects of the antitumor agent perillyl alcohol on H-Ras vs. K-Ras farnesylation and signal transduction in pancreatic cells.
Efficacy of an angiogenesis inhibitor, TNP-470, in xenotransplanted human colorectal cancer with high metastatic potential.
Efficacy of Oxaliplatin/5-Fluorouracil/Capecitabine-Cetuximab Combination Therapy and Its Effects on K-Ras Mutations in Advanced Colorectal Cancer.
EGF receptor signaling is essential for k-ras oncogene-driven pancreatic ductal adenocarcinoma.
EGFr and c-erB2mRNA expression in urinary bladder superficial carcinomas.
EGFR and K-ras mutation analysis in non-small cell lung cancer: comparison of paraffin embedded versus frozen specimens.
EGFR and K-ras mutations along the spectrum of pulmonary epithelial tumors of the lung and elaboration of a combined clinicopathologic and molecular scoring system to predict clinical responsiveness to EGFR inhibitors.
EGFR autophosphorylation but not protein score correlates with histologic and molecular subtypes in lung adenocarcinoma.
EGFR Signals Downregulate Tumor Suppressors miR-143 and miR-145 in Western Diet-Promoted Murine Colon Cancer: Role of G1 Regulators.
EGFR, ErbB2 and Ras but not Src suppress RhoB expression while ectopic expression of RhoB antagonizes oncogene-mediated transformation.
Elaiophylin Is a Potent Hsp90/ Cdc37 Protein Interface Inhibitor with K-Ras Nanocluster Selectivity.
Electrospray ionization quadrupole time-of-flight mass spectrometry and quadrupole mass spectrometry for genotyping single nucleotide substitutions in intact polymerase chain reaction products in K-ras and p53.
Elevated IQGAP1 and CDC42 levels correlate with tumor malignancy of human glioma.
Elevated K-ras activity with cholestyramine and lovastatin, but not konjac mannan or niacin in lung--importance of mouse strain.
Elevated superoxide production by active H-ras enhances human lung WI-38VA-13 cell proliferation, migration and resistance to TNF-alpha.
ELR+ CXC chemokines and oncogenic Ras-mediated tumorigenesis.
Elucidating the mode of action of a typical Ras state 1(T) inhibitor.
Emerging issues in mouse liver carcinogenesis.
Endogenous K-ras signaling in erythroid differentiation.
Endogenous TNF inducibility and prognosis of colorectal cancer.
Endogenous, hyperactive Rac3 controls proliferation of breast cancer cells by a p21-activated kinase-dependent pathway.
Endomembrane control of cell polarity: Relevance to cancer.
Endometrial carcinomas with significant mucinous differentiation associated with higher frequency of k-ras mutations: a morphologic and molecular correlation study.
Endometrioid carcinoma of the endometrium: pathologic and molecular features.
Enhanced expression of c-myc and H-ras oncogenes in Letterer-Siwe disease. A sequential study using colorimetric in situ hybridization.
Enhanced expression of EGF receptor and low frequency of ras mutations in X-ray-induced rat thyroid tumours.
Enhanced expression of Harvey-ras oncogene in FANFT-induced transitional cell carcinoma.
Enhanced expression of oncogene-encoded mRNA in a rat model of colon cancer.
Enhanced Expression of Rab27A Gene by Breast Cancer Cells Promoting Invasiveness and the Metastasis Potential by Secretion of Insulin-Like Growth Factor-II.
Enhanced insulin signaling via Shc in human breast cancer.
Enhanced Krev-1 expression inhibits the growth of pancreatic adenocarcinoma cells.
Enhanced MET Translation and Signaling Sustains K-Ras-Driven Proliferation under Anchorage-Independent Growth Conditions.
Enhanced therapeutic effects for human pancreatic cancer by application K-ras and IGF-IR antisense oligodeoxynucleotides.
Enhancement of migration and invasion of hepatoma cells via a Rho GTPase signaling pathway.
Enriched environment reduces glioma growth through immune and non-immune mechanisms in mice.
EphrinA1 inhibits malignant mesothelioma tumor growth via let-7 microRNA-mediated repression of the RAS oncogene.
Epidermal growth factor receptor and K-Ras in non-small cell lung cancer-molecular pathways involved and targeted therapies.
Epidermal growth factor receptor and K-RAS status in two cohorts of squamous cell carcinomas.
Epidermal growth factor receptor expression and mutational analysis in synovial sarcomas and malignant peripheral nerve sheath tumors.
Epidermal growth factor receptor gene copy number, K-ras mutation and pathological response to preoperative cetuximab, 5-FU and radiation therapy in locally advanced rectal cancer.
Epidermal Growth Factor Receptor Signaling in Nonsmall Cell Lung Cancer.
Epidermal Rac1 regulates the DNA damage response and protects from UV-light-induced keratinocyte apoptosis and skin carcinogenesis.
Epigenetic alteration of DNA in mucosal wash fluid predicts invasiveness of colorectal tumors.
Epigenetic and genetic alterations in duodenal carcinomas are distinct from biliary and ampullary carcinomas.
Epigenetic lesions causing genetic lesions in human cancer: promoter hypermethylation of DNA repair genes.
Epigenetic regulation of TGF-?-induced EMT by JMJD3/KDM6B histone H3K27 demethylase.
Epigenetics and pancreatic cancer: pathophysiology and novel treatment aspects.
Epithelial-to-Mesenchymal Transition and Oncogenic Ras Expression in Resistance to the Protein Kinase C{beta} Inhibitor Enzastaurin in Colon Cancer Cells.
ERBB2 kinase domain mutation in the lung squamous cell carcinoma.
ERK Inhibition Overcomes Acquired Resistance to MEK Inhibitors.
ERK2-dependent reactivation of Akt mediates the limited response of tumor cells with constitutive K-RAS activity to PI3K inhibition.
Erlotinib for Patients with EGFR Wild-Type Metastatic NSCLC: a Retrospective Biomarkers Analysis.
ERM/Rho protein expression in ductal breast cancer: a 15 year follow-up.
Escalating weekly doses of cetuximab and correlation with skin toxicity: A phase I study.
Essential role of Cdc42 in Ras-induced transformation revealed by gene targeting.
Establishment and characterization of a human intrahepatic cholangiocarcinoma cell line derived from an Italian patient.
Establishment and characterization of esophageal squamous cell carcinoma patient-derived xenograft mouse models for preclinical drug discovery.
Establishment of a patient-derived intrahepatic cholangiocarcinoma xenograft model with KRAS mutation.
Establishment of lung cancer patient-derived xenograft models and primary cell lines for lung cancer study.
Estimation of risk based on multiple events in radiation carcinogenesis of rat skin.
Estradiol is trophic for colon cancer in mice: effect on ornithine decarboxylase and c-myc messenger RNA.
Ets1 was significantly activated by ERK1/2 in mutant K-ras stably transfected human adrenocortical cells.
Eugenol inhibits oxidative phosphorylation and fatty acid oxidation via downregulation of c-Myc/PGC-1?/ERR? signaling pathway in MCF10A-ras cells.
Evaluating the treatment of metastatic colorectal cancer with monoclonal antibodies.
Evaluation of active Rac1 levels in cancer cells: A case of misleading conclusions from immunofluorescence analysis.
Evaluation of cII mutations in lung of male Big Blue mice exposed by inhalation to vanadium pentoxide for up to 8 weeks.
Evaluation of clinical relevance of examining K-ras, p16 and p53 mutations along with allelic losses at 9p and 18q in EUS-guided fine needle aspiration samples of patients with chronic pancreatitis and pancreatic cancer.
Evaluation of farnesyl:protein transferase and geranylgeranyl:protein transferase inhibitor combinations in preclinical models.
Evaluation of genetic alterations in cancer-related genes in lung and brain tumors from B6C3F1 mice exposed to 1,3-butadiene or chloroprene.
Evaluation of K-ras and p53 expression in pancreatic adenocarcinoma using the cancer genome atlas.
Evaluation of PCNA, p53, K-ras and LOH in endocrine pancreas tumors.
Evaluation of the diagnostic value of serum tumor markers, and fecal k-ras and p53 gene mutations for pancreatic cancer.
Evidence for aldosterone-dependent growth of renal cell carcinoma.
Evidence for biological effects of metformin in operable breast cancer: a pre-operative, window-of-opportunity, randomized trial.
Evidence for different expression profiles for c-Met, EGFR, PTEN and the mTOR pathway in low and high grade endometrial carcinomas in a cohort of consecutive women. Occurrence of PIK3CA and K-Ras mutations and microsatellite instability.
Evidence for type II cells as cells of origin of K-Ras-induced distal lung adenocarcinoma.
Evidence of Rab3A expression, regulation of vesicle trafficking, and cellular secretion in response to heregulin in mammary epithelial cells.
Evidence that error-prone DNA repair converts dibenzo[a,l]pyrene-induced depurinating lesions into mutations: formation, clonal proliferation and regression of initiated cells carrying H-ras oncogene mutations in early preneoplasia.
Evidence that sprouty 2 is necessary for sarcoma formation by H-Ras oncogene-transformed human fibroblasts.
Evidence that transgenes encoding components of the Wnt signaling pathway preferentially induce mammary cancers from progenitor cells.
Evolution and population genetics of the H-ras minisatellite and cancer predisposition.
Evolution of somatic mutations in mammary tumors in transgenic mice is influenced by the inherited genotype.
Evolution of telomere maintenance and tumour suppressor mechanisms across mammals.
Evolutionarily conserved protein ERH controls CENP-E mRNA splicing and is required for the survival of KRAS mutant cancer cells.
Evolving therapies: farnesyltransferase inhibitors.
Exercise modulates redox-sensitive small GTPase activity in the brain microvasculature in a model of brain metastasis formation.
Exosomal CD47 Plays an Essential Role in Immune Evasion in Ovarian Cancer.
Exosomal miR-2276-5p in Plasma Is a Potential Diagnostic and Prognostic Biomarker in Glioma.
Experimental, Clinical and Morphological Analysis of H-Ras Oncoproteins for Locally Advanced Breast Cancer.
Exploiting the origins of Ras mediated squamous cell carcinoma to develop novel therapeutic interventions.
Exploring the lapse in druggability: Sequence Analysis, Structural Dynamics and binding site characterization of K-RasG12C variant, a feasible oncotherapeutics target.
Expression analysis of Cdc42 in lung cancer and modulation of its expression by curcumin in lung cancer cell lines.
Expression of a Mutant p53 Results in an Age-Related Demographic Shift in Spontaneous Lung Tumor Formation in Transgenic Mice.
Expression of a transfected v-Harvey-ras oncogene in a Dunning rat prostate adenocarcinoma and the development of high metastatic ability.
Expression of activated M-Ras in a murine mammary epithelial cell line induces epithelial-mesenchymal transition and tumorigenesis.
Expression of ARHGAP10 correlates with prognosis of prostate cancer.
Expression of DJ-1 in endometrial cancer: close correlation with clinicopathological features and apoptosis.
Expression of epidermal growth factor receptor, but not K-RAS mutations, is present in congenital cystic airway malformation/congenital pulmonary airway malformation.
Expression of epiregulin and amphiregulin and K-ras mutation status predict disease control in metastatic colorectal cancer patients treated with cetuximab.
Expression of ets-1 is not affected by N-ras or H-ras during oral oncogenesis.
Expression of G protein alpha subunits in normal rat colon and in azoxymethane-induced colonic neoplasms.
Expression of H-ras correlates with metastatic potential: evidence for direct regulation of the metastatic phenotype in 10T1/2 and NIH 3T3 cells.
Expression of H-RASV12 in a zebrafish model of Costello syndrome causes cellular senescence in adult proliferating cells.
Expression of human Krev-1 gene in lungs of transgenic mice and subsequent reduction in multiplicity of ethyl carbamate-induced lung adenomas.
Expression of Kirsten-ras p21 in gastric cancer correlates with tumor progression and is prognostic.
Expression of oncogene products HER2/Neu and Ras and fibrosis-related growth factors bFGF, TGF-beta, and PDGF in bile from biliary malignancies and inflammatory disorders.
Expression of oncogenes and tumor suppressor genes in human hepatocellular carcinoma and hepatoblastoma cell lines.
Expression of oncogenes in human breast cancer specimens.
Expression of Organic Anion Transporting Polypeptides in an H-Ras 12V Transgenic Mouse Model of Spontaneous Hepatocellular Carcinoma.
Expression of p21 ras oncoproteins in human cancers.
Expression of P21-activated kinase 1 and cell division control protein 42 homolog correlates with clinicopathological features and prognosis in cervical carcinoma.
Expression of p21ras-related protein in the plasma and tissue of patients with adenomas and carcinomas of the colon.
Expression of pro-angiogenic factors as potential biomarkers in experimental models of colon cancer.
Expression of Rap 1 suppresses genomic instability of H-ras transformed mouse fibroblasts.
Expression of RAP1B is associated with poor prognosis and promotes an aggressive phenotype in gastric cancer.
Expression of selected gene for acquired drug resistance to EGFR-TKI in lung adenocarcinoma.
Expression of simple epithelial cytokeratins in mouse epidermal keratinocytes harboring Harvey ras gene alterations.
Expression of the 6C3 antigen on murine hematopoietic neoplasms. Association with expression of abl, ras, fes, src, erbB, and Cas NS-1 oncogenes but not with myc.
Expression of the farnesyltransferase beta-subunit gene in human ovarian carcinoma: correlation to K-ras mutation.
Expression of the glucocorticoid receptor and K-ras genes in urethan-induced mouse lung tumors and transformed cell lines.
Expression of the placenta-specific, 100 kDa ras GTPase activating protein in several human cancer cell lines and normal human tissues.
Expression of the receptor tyrosine kinase EphA2 is increased in smokers and predicts poor survival in non-small cell lung cancer.
Expression of the tuberous sclerosis 2 gene product, tuberin, in adult and developing nervous system tissues.
Expression of Tiam-1 in the developing brain suggests a role for the Tiam-1-Rac signaling pathway in cell migration and neurite outgrowth.
Expression pattern of the PRDX2, RAB1A, RAB1B, RAB5A and RAB25 genes in normal and cancer cervical tissues.
Expression status and mutational analysis of the ras and B-raf genes in ovarian granulosa cell and epithelial tumors.
Expressions of Rac1, Tiam1 and Cdc42 in retinoblastoma.
Extended staging results from the detection of isolated tumor cells in the liver of colorectal cancer patients.
Extending the Impact of RAC1b Overexpression to Follicular Thyroid Carcinomas.
Extracellular p53 fragment re-enters K-Ras mutated cells through the caveolin-1 dependent early endosomal system.
EYA4 inhibits hepatocellular carcinoma growth and invasion by suppressing NF-?B-dependent RAP1 transactivation.
Factors affecting prognosis in metastatic colorectal cancer patients.
Failure of catalase to protect against aflatoxin B1-induced mouse lung tumorigenicity.
Familial nasal NK/T-cell lymphoma and pesticide use.
Familial non-medullary thyroid carcinoma (FNMTC): analysis of fPTC/PRN, NMTC1, MNG1 and TCO susceptibility loci and identification of somatic BRAF and RAS mutations.
Farnesol modification of Kirsten-ras exon 4B protein is essential for transformation.
Farnesyltransferase and geranylgeranyltransferase I inhibitors and cancer therapy: lessons from mechanism and bench-to-bedside translational studies.
Farnesyltransferase and geranylgeranyltransferase I inhibitors in cancer therapy: important mechanistic and bench to bedside issues.
Farnesyltransferase inhibitor effects on prostate tumor micro-environment and radiation survival.
Farnesyltransferase inhibitor SCH-66336 downregulates secretion of matrix proteinases and inhibits carcinoma cell migration.
Farnesyltransferase inhibitors: a detailed chemical view on an elusive biological problem.
Farnesyltransferase inhibitors: potential role in the treatment of cancer.
Fast repair of O6-ethylguanine, but not O6-methylguanine, in transcribed genes prevents mutation of H-ras in rat mammary tumorigenesis induced by ethylnitrosourea in place of methylnitrosourea.
Fast simultaneous detection of K-RAS mutations in colorectal cancer.
Fasudil suppresses fibrosarcoma growth by stimulating secretion of the chemokine CXCL14/BRAK.
Fat and K-ras mutations in sporadic colorectal cancer in The Netherlands Cohort Study.
Feasibility of cetuximab given with a simplified schedule every 2 weeks in advanced colorectal cancer: a multicenter, retrospective analysis.
Fecal multiple molecular tests to detect colorectal cancer in stool.
Fendiline Enhances the Cytotoxic Effects of Therapeutic Agents on PDAC Cells by Inhibiting Tumor-Promoting Signaling Events: A Potential Strategy to Combat PDAC.
Fendiline inhibits K-Ras plasma membrane localization and blocks K-Ras signal transmission.
Fibroblast activation protein-? promotes ovarian cancer cell proliferation and invasion via extracellular and intracellular signaling mechanisms.
Fibroblast growth factor 2 restrains Ras-driven proliferation of malignant cells by triggering RhoA-mediated senescence.
Fibroblast-Mediated Collagen Remodeling Within the Tumor Microenvironment Facilitates Progression of Thyroid Cancers Driven by BrafV600E and Pten Loss.
Fibulin-2 is a driver of malignant progression in lung adenocarcinoma.
FilGAP, a GAP protein for Rac, regulates front-rear polarity and tumor cell migration through the ECM.
Filling GAPs in our knowledge: ARHGAP11A and RACGAP1 act as oncogenes in basal-like breast cancers.
Flat-elevated and depressed, subtypes of flat early colorectal cancers, should be distinguished by their pathological features.
Flexible-body motions of calmodulin and the farnesylated hypervariable region yield a high-affinity interaction enabling K-Ras4B membrane extraction.
FLIM-FRET imaging in vivo reveals 3D-environment spatially regulates RhoGTPase activity during cancer cell invasion.
Fluorescence background subtraction technique for hybrid fluorescence molecular tomography/x-ray computed tomography imaging of a mouse model of early stage lung cancer.
Fluorescence spectroscopy for detection of malignancy: H-ras overexpressing fibroblasts as a model.
Follow-Up Study of K-ras Mutations in the Plasma of Patients With Pancreatic Cancer: Correlation With Clinical Features and Carbohydrate Antigen 19-9.
Food and nutrient intakes and K-ras mutations in exocrine pancreatic cancer.
Formation of benzo[a]pyrene diol epoxide-DNA adducts at specific guanines within K-ras and p53 gene sequences: stable isotope-labeling mass spectrometry approach.
Formation of extracellular matrix-digesting invadopodia by primary aortic smooth muscle cells.
Formin-like 2 drives amoeboid invasive cell motility downstream of RhoC.
Foxm1 transcription factor is required for the initiation of lung tumorigenesis by oncogenic Kras(G12D.)
FRA1 is a determinant for the difference in RAS-induced transformation between human and rat fibroblasts.
Fragile Histidine Triad Mediated Tumor Suppression of Lung Cancer by Targeting Multiple Components of the Ras/Rho GTPase Molecular Switch.
Frameshift mutations at mononucleotide repeats in caspase-5 and other target genes in endometrial and gastrointestinal cancer of the microsatellite mutator phenotype.
Free circulating nucleic acids in plasma and serum (CNAPS) -- Useful for the detection of lung cancer patients?
Frequency and clinicopathology associations of K-ras mutations in colorectal cancer in a northeast Mexican population.
Frequency of K-ras mutations in pancreatic intraductal neoplasias associated with pancreatic ductal adenocarcinoma and chronic pancreatitis: a meta-analysis.
Frequency of p16(INK4A) alterations and K-ras mutations in intrahepatic cholangiocarcinoma of the liver.
Frequency of ras mutations in liver neoplasms from B6C3F1 mice exposed to tetrafluoroethylene for two years.
Frequent and characteristic K-ras activation and absence of p53 protein accumulation in aberrant crypt foci of the colon.
Frequent and characteristic K-ras activation in aberrant crypt foci of colon. Is there preference among K-ras mutants for malignant progression?
Frequent c-Ha-ras gene mutations in rat mammary carcinomas induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.
Frequent deregulations in the hedgehog signaling network and cross-talks with the epidermal growth factor receptor pathway involved in cancer progression and targeted therapies.
Frequent detection of K-ras mutation in stool samples of colorectal carcinoma patients after improved DNA extraction: comparison with tissue samples.
Frequent down-regulation of hRAB37 in metastatic tumor by genetic and epigenetic mechanisms in lung cancer.
Frequent hypermethylation of RASSF1A in early flat-type colorectal tumors.
Frequent involvement of ras-signalling pathways in both polypoid-type and flat-type early-stage colorectal cancers.
Frequent K-ras mutations and absence of p53 mutations in mucin-producing tumors of the pancreas.
Frequent p53 alterations but low incidence of ras mutations in UV-B-induced skin tumors of hairless mice.
Frequent polymorphic variations but rare tumour specific mutations of the S100A2 on 1q21 in non-small cell lung cancer.
Frequent polymorphism of peroxisome proliferator activated receptor gamma gene in colorectal cancer containing wild-type K-ras gene.
Frequent ras gene mutations in squamous cell cervical cancer.
Friend leukemia virus integration 1 activates the Rho GTPase pathway and is associated with metastasis in breast cancer.
From pancreatic intraepithelial neoplasia to cancer: a dramatic progression with K-ras status analysis.
Function of miR-200a in proliferation and apoptosis of non-small cell lung cancer cells.
Function of RasGRP3 in the formation and progression of human breast cancer.
Function of Rho GTPase Activating Protein 11A in Tumors.
Function, Significance, and Regulation of Rap1b in Malignancy.
Functional and clinical evidence for NDRG2 as a candidate suppressor of liver cancer metastasis.
Functional implications of structural predictions for alternative splice proteins expressed in Her2/neu-induced breast cancers.
Functional interaction of p53 with HPV18 E6, c-myc and H-ras in 3T3 cells.
Functional loss of tumour suppressor genes in multistage chemical carcinogenesis.
Functional specificity of ras isoforms: so similar but so different.
Functionalized Graphene@Gold Nanostar/Lipid for Pancreatic Cancer Gene and Photothermal Synergistic Therapy under Photoacoustic/Photothermal Imaging Dual-Modal Guidance.
Fuzzy modeling and global optimization to predict novel therapeutic targets in cancer cells.
Gain-of-function mutant p53 activates small GTPase Rac1 through SUMOylation to promote tumor progression.
Gain-of-function mutant p53 but not p53 deletion promotes head and neck cancer progression in response to oncogenic K-ras.
Galectin-1-mediated tumor invasion and metastasis, up-regulated matrix metalloproteinase expression, and reorganized actin cytoskeletons.
Galectin-3 augments K-Ras activation and triggers a Ras signal that attenuates ERK but not phosphoinositide 3-kinase activity.
Galectin-3 mediates cross-talk between K-Ras and Let-7c tumor suppressor microRNA.
Galectin-3 promotes chronic activation of K-Ras and differentiation block in malignant thyroid carcinomas.
Galectin-3 regulates a molecular switch from N-Ras to K-Ras usage in human breast carcinoma cells.
Galectin-3 regulates RasGRP4-mediated activation of N-Ras and H-Ras.
GANT61 plays anti-tumor effects by inducing oxidative stress through miRNA-1286/RAB31 axis in osteosarcoma.
Garlic extract in bladder cancer prevention: Evidence from T24 bladder cancer cell xenograft model, tissue microarray, and gene network analysis.
Gastric and intestinal phenotypic marker expression in early differentiated-type tumors of the stomach: clinicopathologic significance and genetic background.
Gastric-type endocervical glandular neoplasms associated with aberrant p16 expression and K-RAS gene mutation in Peutz-Jeghers syndrome.
Gd-complexes of DTPA-bis(amide) conjugates of tranexamic acid and its esters with high relaxivity and stability for magnetic resonance imaging.
Gd-EOB-DTPA Enhanced Micro-MR Imaging of Hepatic Tumors in H-ras 12V Transgenic Mice.
GEF-H1 mediates tumor necrosis factor-alpha-induced Rho activation and myosin phosphorylation: role in the regulation of tubular paracellular permeability.
Geldanamycin anisimycins activate Rho and stimulate Rho- and ROCK-dependent actin stress fiber formation.
Gemcitabine and ISIS-2503 for patients with locally advanced or metastatic pancreatic adenocarcinoma: a North Central Cancer Treatment Group phase II trial.
Gender is a risk factor for lung cancer.
Gene amplification and multiple mutations of the K-ras oncogene in Kaposi's sarcoma.
Gene expression and protein array studies of folliculin-regulated pathways.
Gene expression profile after cardiopulmonary bypass and cardioplegic arrest.
Gene expression profiling of NMU-induced rat mammary tumors: cross species comparison with human breast cancer.
Gene expression studies demonstrate that the K-ras/Erk MAP kinase signal transduction pathway and other novel pathways contribute to the pathogenesis of cumene-induced lung tumors.
Gene replacement strategies for cancer.
Gene Replacement Strategies for Lung Cancer.
Gene therapy in pancreatic cancer.
Gene-environment interactions in the pre-Industrial Era: the cancer of King Ferrante I of Aragon (1431-1494).
Gene-modified spontaneous Epstein-Barr virus-transformed lymphoblastoid cell lines as autologous cancer vaccines: mutated p21 ras oncogene as a model.
Generalizing molecular results arising from incomplete biological samples: expected bias and unexpected findings.
Generating mutations but providing chemosensitivity: the role of O6-methylguanine DNA methyltransferase in human cancer.
Generation and Analysis of Mouse Intestinal Tumors and Organoids Harboring APC and K-Ras Mutations.
Generation of a ribozyme-adenoviral vector against K-ras mutant human lung cancer cells.
Generation of Cancerous Neural Stem Cells Forming Glial Tumor by Oncogenic Stimulation.
Generation of KS-58 as the first K-Ras(G12D)-inhibitory peptide presenting anti-cancer activity in vivo.
Generation of monoclonal antibodies specific for ras p21 Glu-12 oncoproteins: detection in carcinogen-induced mammary carcinomas.
Generation of stable CD4+ and CD8+ T cell lines from patients immunized with ras oncogene-derived peptides reflecting codon 12 mutations.
Genes and viruses in hepatobiliary neoplasia.
Genes are differentially expressed in the epididymal fat of rats rendered obese by a high-fat diet.
Genetic aberrations of the K-ras proto-oncogene in bladder cancer in Kashmiri population.
Genetic ablation of cyclooxygenase-2 in keratinocytes produces a cell-autonomous defect in tumor formation.
Genetic abnormalities and microsatellite instability in colorectal cancer.
Genetic abnormalities in pancreatic cancer.
Genetic abnormalities in sporadic parathyroid adenomas.
Genetic abnormalities involved in the pathogenesis of gallbladder carcinoma.
Genetic alteration in carcinoid tumors of the lung.
Genetic alterations and growth pattern in biliary duct carcinomas: loss of heterozygosity at chromosome 5q bears a close relation with polypoid growth.
Genetic alterations detected on chromosomes 13 and 14 in Chinese non-small cell lung carcinomas.
Genetic alterations distinguish different types of ovarian tumors.
Genetic alterations in adenoma-carcinoma sequencing of intraductal papillary-mucinous neoplasm of the pancreas.
Genetic alterations in gallbladder adenoma, dysplasia and carcinoma.
Genetic alterations in gallbladder carcinoma.
Genetic alterations in goblet cell carcinoids of the vermiform appendix and comparison with gastrointestinal carcinoid tumors.
Genetic alterations in K-ras and p53 cancer genes in lung neoplasms from B6C3F1 mice exposed to cumene.
Genetic alterations in K-ras and p53 cancer genes in lung neoplasms from Swiss (CD-1) male mice exposed transplacentally to AZT.
Genetic alterations in locally advanced stage II/III colon cancer: a search for prognostic markers.
Genetic alterations in mouse lung tumors: implications for cancer chemoprevention.
Genetic alterations in ovarian carcinoma: with specific reference to histological subtypes.
Genetic alterations in p53 and k-ras in lung-cancer in relation to histopathology of the tumor and smoking history of the patient.
Genetic alterations in pancreatic carcinoma.
Genetic alterations in the Catnb gene but not the H-ras gene in hepatocellular neoplasms and hepatoblastomas of B6C3F(1) mice following exposure to diethanolamine for 2 years.
Genetic alterations in the K-Ras gene influence the prognosis in patients with cervical cancer treated by radiotherapy.
Genetic alterations in ulcerative colitis-associated neoplasia focusing on APC, K-ras gene and microsatellite instability.
Genetic alterations of cancer-related genes in glass fiber-induced transformed cells.
Genetic alterations of K-ras may reflect prognosis in stage III colon cancer patients below 60 years of age.
Genetic Alterations of K-ras, p53, c-erbB-2, and DPC4 in Pancreatic Ductal Adenocarcinoma and Their Correlation With Patient Survival.
Genetic analysis of benign ovarian tumors.
Genetic analysis of H-ras intron-1 polymorphic and variable tandem repeat regions in human breast cancer.
Genetic analysis of lung tumours of non-smoking subjects: p53 gene mutations are constantly associated with loss of heterozygosity at the FHIT locus.
Genetic analysis of sinonasal adenocarcinoma phenotypes: distinct alterations of histogenetic significance.
Genetic analysis of the catalytic domain of the GAP gene in human lung cancer cell lines.
Genetic and cellular changes in colorectal cancer: proposed targets of chemopreventive agents.
Genetic and clinical features of human pancreatic ductal adenocarcinomas with widespread microsatellite instability.
Genetic and epigenetic alterations of Ras signalling pathway in colorectal neoplasia: analysis based on tumour clinicopathological features.
Genetic and epigenetic changes in fibrosis-associated hepatocarcinogenesis in mice.
Genetic and epigenetic changes in primary metastatic and nonmetastatic colorectal cancer.
Genetic and epigenetic changes in stomach cancer.
Genetic and epigenetic contributions to colorectal cancer.
Genetic and histological assessment of surgical margins in resected liver metastases from colorectal carcinoma: minimum surgical margins for successful resection.
Genetic and protein markers related to in situ growth and multiplicity in small sporadic colorectal adenomas.
Genetic basis of pancreatic cancer.
Genetic basis of pituitary adenoma invasiveness: a review.
Genetic changes and histopathological types in colorectal tumors from patients with familial adenomatous polyposis.
Genetic changes during mouse skin tumorigenesis.
Genetic changes in contralateral bronchioloalveolar carcinomas of the lung.
Genetic changes in skin tumor progression: correlation between presence of a mutant ras gene and loss of heterozygosity on mouse chromosome 7.
Genetic deletion of the Pten tumor suppressor gene promotes cell motility by activation of Rac1 and Cdc42 GTPases.
Genetic detection of colorectal cancer cells in circulation and lymph nodes.
Genetic detection of lymph node micrometastases: a selection criterion for liver transplantation in patients with liver metastases after colorectal cancer.
Genetic determinants of cancer coagulopathy, angiogenesis and disease progression.
Genetic diagnosis identifies occult lymph node metastases undetectable by the histopathological method.
Genetic diagnosis of lymph-node metastasis in colorectal cancer.
Genetic factors in lung disease. Part II: Lung cancer and angiotensin converting enzyme gene.
Genetic factors in ovarian carcinoma.
Genetic heterogeneity in patients with multiple neoplastic lung lesions: a report of three cases.
Genetic instability in renal cell carcinoma.
Genetic interaction between Rb and K-ras in the control of differentiation and tumor suppression.
Genetic mechanisms in Apc-mediated mammary tumorigenesis.
Genetic pathways in the evolution of morphologically distinct colorectal neoplasms.
Genetic similarities between Spitz nevus and Spitzoid melanoma in children.
Genetic studies on lung tumor susceptibility and histogenesis in mice.
Genetic susceptibility to non-polyposis colorectal cancer.
Genetic, epigenetic, and clinicopathologic features of gastric carcinomas with the CpG island methylator phenotype and an association with Epstein-Barr virus.
Genetically Engineered Mouse Models of K-Ras-Driven Lung and Pancreatic Tumors: Validation of Therapeutic Targets.
Genetics of pancreatic cancer. From genes to families.
Genome-wide analysis of chromosomal alterations in patients with esophageal squamous cell carcinoma exposed to tobacco and betel quid from high-risk area in India.
Genome-wide single-nucleotide polymorphism arrays in endometrial carcinomas associate extensive chromosomal instability with poor prognosis and unveil frequent chromosomal imbalances involved in the PI3-kinase pathway.
Genomic alterations in sarcomas: a histologic correlative study with use of oncogene panels.
Genomic amplicons target vesicle recycling in breast cancer.
Genomic heterogeneity and instability in colorectal cancer: spectral karyotyping, glutathione transferase-Ml and ras.
Genomic instability and loh at 2 polymorphic sites in the h-ras1 gene.
Genomic instability, as measured by microsatellite alterations, is not associated with liver tumor development in the genetically susceptible B6C3F1 mouse.
Genomic loss of tumor suppressor miRNA-204 promotes cancer cell migration and invasion by activating AKT/mTOR/Rac1 signaling and actin reorganization.
Genotoxicity of pyrrolizidine alkaloids.
Genotyping of K-ras codons 12 and 13 mutations in colorectal cancer by capillary electrophoresis.
Geranylgeranyltransferase I as a target for anti-cancer drugs.
Geranylgeranyltransferase I inhibitor GGTI-2154 induces breast carcinoma apoptosis and tumor regression in H-Ras transgenic mice.
Geranylgeranyltransferase I promotes human glioma cell growth through Rac1 membrane association and activation.
GFAP-Cre-Mediated Activation of Oncogenic K-ras Results in Expansion of the Subventricular Zone and Infiltrating Glioma.
GGT to GTT transversions in codon 12 of the K-ras oncogene in rat renal sarcomas induced with nickel subsulfide or nickel subsulfide/iron are consistent with oxidative damage to DNA.
GGTase-I deficiency reduces tumor formation and improves survival in mice with K-RAS-induced lung cancer.
Ghrelin and the growth hormone secretagogue receptor constitute a novel autocrine pathway in astrocytoma motility.
Glioblastoma: a pathogenic crosstalk between tumor cells and pericytes.
Glioma-Targeted Drug Delivery Enabled by a Multifunctional Peptide.
Glucocorticoid and estrogen receptors have elevated activity in human endometrial and ovarian tumors as compared to the adjacent normal tissues and recognize sequence elements of the H-ras proto-oncogene.
Glucocorticoids mediate induction of microRNA-708 to suppress ovarian cancer metastasis through targeting Rap1B.
Glucose insult elicits hyperactivation of cancer stem cells through miR-424-cdc42-prdm14 signalling axis.
Glucose starvation induces cell death in K-ras-transformed cells by interfering with the hexosamine biosynthesis pathway and activating the unfolded protein response.
Glucose-6-Phosphate Dehydrogenase Is Not Essential for K-Ras-Driven Tumor Growth or Metastasis.
Glutamate E15 and E171 are Hotspots in p60TRP-Related Cancer.
Glutaminase 2 is a novel negative regulator of small GTPase Rac1 and mediates p53 function in suppressing metastasis.
Glutathione S-transferase mu1 null genotype is associated with K-ras gene mutation in lung adenocarcinoma among smokers.
GNA11 and N-RAS mutations: alternatives for MAPK pathway activating GNAQ mutations in primary melanocytic tumours of the central nervous system.
Group IIa secretory phospholipase expression correlates with group IIa secretory phospholipase inhibition-mediated cell death in K-ras mutant lung cancer cells.
Growth inhibition of human pancreatic cancer cell lines by anti-sense oligonucleotides specific to mutated K-ras genes.
Growth inhibition of non-small-cell lung carcinoma by BN/GRP antagonist is linked with suppression of K-Ras, COX-2, and pAkt.
Growth inhibitory effect of anti-K-ras adenovirus on lung cancer cells.
GSTM1, P53 and K-ras molecular detection in resectable non-small cell lung cancer by denaturing gradient gel electrophoresis-bronchoalveolar lavage fluid analysis.
GTP-State-Selective Cyclic Peptide Ligands of K-Ras(G12D) Block Its Interaction with Raf.
GTPases Rho distribution in intraepithelial and invasive neoplasias of the uterine cervix.
Guanine Nucleotide Exchange Factors for RhoGTPases: Good Therapeutic Targets for Cancer Therapy?
Guanine nucleotide induced conformational change of Cdc42 revealed by hydrogen/deuterium exchange mass spectrometry.
H- and K-ras mutational profiles in chemically induced liver tumors from B6C3F1 and CD-1 mice.
H-RAS 81 polymorphism is significantly associated with aneuploidy in follicular tumors of the thyroid.
H-ras activation and ras p21 expression in bladder tumors induced in F344/NCr rats by N-butyl-N-(4-hydroxybutyl)nitrosamine.
H-ras activation in benign and self-regressing skin tumors (keratoacanthomas) in both humans and an animal model system.
H-ras activation is an early event in the ptaquiloside-induced carcinogenesis: comparison of acute and chronic toxicity in rats.
H-ras and c-fos exhibit similar expression patterns during most stages of oral oncogenesis.
H-ras and K-ras gene mutations in primary human soft tissue sarcoma: concomitant mutations of the ras genes.
H-Ras and K-Ras Oncoproteins Induce Different Tumor Spectra When Driven by the Same Regulatory Sequences.
H-ras and Nm23-H1 gene expression and proteolytic activity in squamous cell carcinoma of the uterine cervix.
H-ras Consensus Sequence and Mutations in Primary Hepatocellular Carcinomas of Lemurs and Lorises.
H-ras gene amplification or mutation is not common in human primary breast cancer.
H-ras gene mutations in salivary gland mucoepidermoid carcinomas.
H-ras gene mutations in salivary gland pleomorphic adenomas.
H-Ras gene takes part to the host immune response to COVID-19.
H-Ras induces Nrf2-Pin1 interaction: Implications for breast cancer progression.
H-RAS mutation is a key molecular feature of pediatric urothelial bladder cancer. A detailed report of three cases.
H-RAS mutations are restricted to sporadic pheochromocytomas lacking specific clinical or pathological features: data from a multi-institutional series.
H-ras mutations at codon 61 or 13 in tumors initiated with a NO donor in mouse skin.
H-ras oncogene activation in invasive UVR-induced corneal sarcomas of the opossum Monodelphis domestica.
H-ras oncogene mutation and human papillomavirus infection in oral carcinomas.
H-ras oncogene mutation in dedifferentiated liposarcoma. Polymerase chain reaction-restriction fragment length polymorphism analysis.
H-ras oncogene mutation spectra in B6C3F1 and C57BL/6 mouse liver tumors provide evidence for TCDD promotion of spontaneous and vinyl carbamate-initiated liver cells.
H-ras oncogene mutations during development of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced rat mammary gland cancer.
H-ras oncogene mutations in the urine of patients with bladder-tumors - description of a noninvasive method for the detection of neoplasia.
H-ras protooncogene mutations in human thyroid neoplasms.
H-Ras regulation of TRAIL death receptor mediated apoptosis.
H-ras transformation sensitizes volume-activated anion channels and increases migratory activity of NIH3T3 fibroblasts.
H-ras-1 gene mutations in basal cell carcinoma: automated direct sequencing of clinical specimens.
H-Ras-driven tumoral maintenance is sustained through caveolin-1-dependent alterations in calcium signaling.
H-Ras-specific activation of NF-kappaB protects NIH 3T3 cells against stimulus-dependent apoptosis.
HACE1 is a potential tumor suppressor in osteosarcoma.
Hammerhead ribozymes as therapeutic agents for bladder cancer.
Harnessing membrane trafficking to promote cancer spreading and invasion: The case of RAB2A.
Harvey ras (H-ras) point mutations are induced by 4-nitroquinoline-1-oxide in murine oral squamous epithelia, while squamous cell carcinomas and loss of heterozygosity occur without additional exposure.
HDAC6 and SIRT2 Regulate the Acetylation State and Oncogenic Activity of Mutant K-RAS.
Heart myxoma develops oncogenic and metastatic phenotype.
Heparin co-factor II enhances cell motility and promotes metastasis in non-small cell lung cancer.
Hepatic disseminated tumor cells in colorectal cancer UICC stage 4 patients: prognostic implications.
Hepatic tumors induced by carbon tetrachloride in transgenic mice carrying a human c-H-ras proto-oncogene without mutations.
Hepatitis B Virus X Protein Stimulates Proliferation, Wound Closure and Inhibits Apoptosis of HuH-7 Cells via CDC42.
Hepatitis C virus core protein cooperates with ras and transforms primary rat embryo fibroblasts to tumorigenic phenotype.
Hepatocarcinogenicity of chlordane in B6C3F1 and B6D2F1 male mice: evidence for regression in B6C3F1 mice and carcinogenesis independent of ras proto-oncogene activation.
Hepatocyte expression of tumor associated aldehyde dehydrogenase (ALDH-3) and p21 Ras following diethylnitrosamine (DEN) initiation and chronic exposure to di(2-ethylhexyl)phthalate (DHEP).
Heterogeneity of DNA methylation status analyzed by bisulfite-PCR-SSCP and correlation with clinico-pathological characteristics in colorectal cancer.
Heterogeneous distribution of K-ras mutations in primary colon carcinomas: implications for EGFR-directed therapy.
Heterogeneous distribution of K-ras-mutated epithelia in mucinous ovarian tumors with special reference to histopathology.
Heterogeneous genetic alterations in ovarian mucinous tumors: application and usefulness of laser capture microdissection.
Heterozygous inactivation of TGF-beta1 increases the susceptibility to chemically induced mouse lung tumorigenesis independently of mutational activation of K-ras.
High affinity for farnesyltransferase and alternative prenylation contribute individually to K-Ras4B resistance to farnesyltransferase inhibitors.
High Expression of Cell Division Cycle 42 Promotes Pancreatic Cancer Growth and Predicts Poor Outcome of Pancreatic Cancer Patients.
High expression of RAB27A and TP53 in pancreatic cancer predicts poor survival.
High expression of RAB38 promotes malignant progression of pancreatic cancer.
High expression of Rap2A is associated with poor prognosis of patients with hepatocellular carcinoma.
High expression of Ras-related protein 1A promotes an aggressive phenotype in colorectal cancer via PTEN/FOXO3/CCND1 pathway.
High expression of small GTPase Rab3D promotes cancer progression and metastasis.
High frequency mutation in codons 12 and 61 of H-ras oncogene in chewing tobacco-related human oral carcinoma in India.
High frequency of activated K-ras codon 15 mutant in colorectal carcinomas from Taiwanese patients.
High Frequency of Codon 12 but not Codon 13 and 61 K-ras Gene Mutations in Invasive Ductal Carcinoma of Breast in a South Indian Population.
High frequency of codon 61 K-ras A-->T transversions in lung and Harderian gland neoplasms of B6C3F1 mice exposed to chloroprene (2-chloro-1,3-butadiene) for 2 years, and comparisons with the structurally related chemicals isoprene and 1,3-butadiene.
High frequency of K-ras mutations in normal appearing lung tissues and sputum of patients with lung cancer.
High frequency of K-ras mutations in spontaneous and vinyl carbamate-induced lung tumors of relatively resistant B6CF1 (C57BL/6J x BALB/cJ) mice.
High frequency of ras mutations in forestomach and lung tumors of B6C3F1 mice exposed to 1-amino-2,4-dibromoanthraquinone for 2 years.
High incidence of H-ras oncogene mutations in squamous cell carcinoma of lip vermilion.
High incidence of point mutation in K-ras codon 12 in carcinoma of the fallopian tube.
High level of galectin-1 expression is a negative prognostic predictor of recurrence in laryngeal squamous cell carcinomas.
High levels of c-myc protein in human breast tumours determined by a sensitive ELISA technique.
High Levels of Cell-Free Circulating Nucleic Acids in Pancreatic Cancer are Associated With Vascular Encasement, Metastasis and Poor Survival.
High Rab27A expression indicates favorable prognosis in CRC.
High yields of K-ras mutations in intraductal papillary mucinous tumors and invasive adenocarcinomas induced by N-nitroso(2-hydroxypropyl)(2-oxopropyl)amine in the pancreas of female Syrian hamsters.
High-Affinity Interaction of the K-Ras4B Hypervariable Region with the Ras Active Site.
High-degree tumor budding and podia-formation in sporadic colorectal carcinomas with K-ras gene mutations.
High-LET Radiation Increases Tumor Progression in a K-Ras-Driven Model of Lung Adenocarcinoma.
High-level microsatellite instability is not involved in gallbladder carcinogenesis.
High-throughput amenable fluorescence-assays to screen for calmodulin-inhibitors.
High-throughput screening identifies small molecules that bind to the RAS:SOS:RAS complex and perturb RAS signaling.
Higher expression of K-ras is associated with parathyroid hormone-related protein-induced hypercalcaemia in renal cell carcinoma.
Highly methylated genes in colorectal neoplasia: implications for screening.
Histamine receptors signalling in epidermal tumor cell lines with H-ras gene alterations.
Histochemical characterization of non-neuroendocrine tumors and neuroendocrine cell hyperplasia induced in hamster lung by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone with or without hyperoxia.
Histogenesis and the role of p53 and K-ras mutations in hepatocarcinogenesis by glyceryl trinitrate (nitroglycerin) in male F344 rats.
Histological and genetic changes in malignant transformation of gallbladder adenoma.
Histone deacetylase 1 represses the small GTPase RhoB expression in human nonsmall lung carcinoma cell line.
Histopathology of salivary and mammary gland tumors in transgenic mice expressing a human Ha-ras oncogene.
Histoprognostic markers role in colorectal cancer.
HIV protease inhibitors block Akt signaling and radiosensitize tumor cells both in vitro and in vivo.
HLA molecules in basal cell carcinoma of the skin.
Hormone dependent and independent mammary tumor development form N-methyl-N-nitrosourea-treated rat mammary epithelial cell xenografts in the nude mouse: multiple pathways and H-ras activation.
How to integrate molecular targeted agents in the continuum of care.
Hsa-miR-1 suppresses breast cancer development by down-regulating K-ras and long non-coding RNA MALAT1.
Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells.
Human hepatocyte carcinogenesis (Review).
Human ovarian cancer of the surface epithelium.
Human papillomavirus and mutated H-ras oncogene in cervical carcinomas and pathological negative pelvic lymph nodes: a retrospective follow-up.
Human Papillomavirus DNA and Oncogene Alterations in Colorectal Tumors.
Human urine contains small, 150 to 250 nucleotide-sized, soluble DNA derived from the circulation and may be useful in the detection of colorectal cancer.
Human ZNF312b promotes the progression of gastric cancer by transcriptional activation of the K-ras gene.
Hurthle cell thyroid tumors. An immunohistochemical study.
Hyaluronan-CD44 interaction promotes microRNA signaling and RhoGTPase activation leading to tumor progression.
Hyaluronan-CD44 interaction with IQGAP1 promotes Cdc42 and ERK signaling, leading to actin binding, Elk-1/estrogen receptor transcriptional activation, and ovarian cancer progression.
Hyaluronan-mediated CD44 activation of RhoGTPase signaling and cytoskeleton function promotes tumor progression.
Hydrogen gas represses the progression of lung cancer via down-regulating CD47.
Hyperglycemia promotes K-Ras-induced lung tumorigenesis through BASCs amplification.
Hypermethylation of CpG island in O6-methylguanine-DNA methyltransferase gene was associated with K-ras G to A mutation in colorectal tumor.
Hypermethylation-associated inactivation of p14(ARF) is independent of p16(INK4a) methylation and p53 mutational status.
Hypomethylated Rab27b is a progression-associated prognostic biomarker of glioma regulating MMP-9 to promote invasion.
Hypoxia in models of lung cancer: implications for targeted therapeutics.
Hypoxia promotes Rab5 activation, leading to tumor cell migration, invasion and metastasis.
Hypoxia stimulates carcinoma invasion by stabilizing microtubules and promoting the Rab11 trafficking of the alpha6beta4 integrin.
Hypoxia stimulates invasion and migration of human cervical cancer cell lines HeLa/SiHa through the Rab11 trafficking of integrin ?v?3/FAK/PI3K pathway-mediated Rac1 activation.
Hypoxia-induced acetylation of PAK1 enhances autophagy and promotes brain tumorigenesis via phosphorylating ATG5.
Hypoxia-inducible factor 1 alpha is required for the tumourigenic and aggressive phenotype associated with Rab25 expression in ovarian cancer.
Identification and characterization of 2'-deoxyadenosine adducts formed by isoprene monoepoxides in vitro.
Identification and characterization of Dlc1 isoforms in the mouse and study of the biological function of a single gene trapped isoform.
Identification and Characterization of Von Hippel-Lindau-Recruiting Proteolysis Targeting Chimeras (PROTACs) of TANK-Binding Kinase 1.
Identification of a farnesol analog as a Ras function inhibitor using both an in vivo Ras activation sensor and a phenotypic screening approach.
Identification of a MET-eIF4G1 translational regulation axis that controls HIF-1? levels under hypoxia.
Identification of a metabolic and canonical biomarker signature in Mexican HR+/HER2-, triple positive and triple-negative breast cancer patients.
Identification of a small molecule with synthetic lethality for K-ras and protein kinase C iota.
Identification of an oncogenic RAB protein.
Identification of bronchioalveolar stem cells in normal lung and lung cancer.
Identification of cancer initiating cells in K-Ras driven lung adenocarcinoma.
Identification of cancer-associated missense mutations in hace1 that impair cell growth control and Rac1 ubiquitylation.
Identification of Differentially Expressed Genes in Papillary Thyroid Carcinomas With and Without Rearrangements of the Tyrosine Kinase Receptors RET and/or NTRK1.
Identification of Gene Loci That Overlap Between Mental Disorders and Poor Prognosis of Cancers.
Identification of genetic polymorphisms through comparative DNA sequence analysis on the K-ras gene: implications for lung tumor susceptibility.
Identification of H-ras mutations in urine sediments complements cytology in the detection of bladder tumors.
Identification of h-ras-specific motif for the activation of invasive signaling program in human breast epithelial cells.
Identification of hepatocellular carcinoma-related genes associated with macrophage differentiation based on bioinformatics analyses.
Identification of insulin-like growth factor binding protein-3 as a farnesyl transferase inhibitor SCH66336-induced negative regulator of angiogenesis in head and neck squamous cell carcinoma.
Identification of K-ras mutations in pancreatic juice in the early diagnosis of pancreatic cancer.
Identification of key genes in invasive clinically non-functioning pituitary adenoma by integrating analysis of DNA methylation and mRNA expression profiles.
Identification of lung micrometastatic tumor foci in nude mice with implanted tumor using laser capture microdissection and PCR-single-strand conformation polymorphism.
Identification of miRNA Master Regulators in Breast Cancer.
Identification of mutant K-RAS in pituitary macroadenoma.
Identification of mutant K-Ras-dependent phenotypes using a panel of isogenic cell lines.
Identification of overlapping epitopes in mutant ras oncogene peptides that activate CD4+ and CD8+ T cell responses.
Identification of P-Rex1 in the Regulation of Liver Cancer Cell Proliferation and Migration via HGF/c-Met/Akt Pathway.
Identification of pharmacokinetically stable 3, 10-dibromo-8-chlorobenzocycloheptapyridine farnesyl protein transferase inhibitors with potent enzyme and cellular activities.
Identification of Rab27a as a host factor for oncolytic herpes virus susceptibility to tumor cells.
Identification of Rab6a as a New Target of microRNA-155 Involved in Regulating Lipopolysaccharide-Induced TNF Secretion.
Identification of ras oncogene mutations in the stool of patients with curable colorectal tumors.
Identification of Ras-related nuclear protein, targeting protein for xenopus kinesin-like protein 2, and stearoyl-CoA desaturase 1 as promising cancer targets from an RNAi-based screen.
Identification of rCop-1, a new member of the CCN protein family, as a negative regulator for cell transformation.
Identification of secreted proteins that mediate cell-cell interactions in an in vitro model of the lung cancer microenvironment.
Identification of subjects at risk for colorectal carcinoma through a test based on K-ras determination in the stool.
Identification of the integrin-binding site on coagulation factor VIIa required for proangiogenic PAR2 signaling.
Identification of translocation products but not K-RAS mutations in memory B cells from patients with multiple myeloma.
Identifying Cancer-Relevant Mutations in the DLC START Domain Using Evolutionary and Structure-Function Analyses.
Identifying conserved molecular targets required for cell migration of glioblastoma cancer stem cells.
Illuminating Radiogenomic Characteristics of Glioblastoma Multiforme through Integration of MR Imaging, Messenger RNA Expression, and DNA Copy Number Variation.
Immortalized bovine pancreatic duct cells become tumorigenic after transfection with mutant k-ras.
Immunocytochemical analysis of the synaptic proteins SNAP-25 and Rab3A in human pituitary adenomas. Overexpression of SNAP-25 in the mammmosomatotroph lineages.
Immunocytochemical demonstration and significance of p21 ras family oncogene product in benign and malignant breast disease.
Immunocytochemical demonstration of p21 ras family oncogene product in normal mucosa and in premalignant and malignant tumours of the colorectum.
Immunocytochemical localization of p21 ras gene product in human hepatoma cell lines and corresponding tumors in athymic mice.
Immunocytochemically detectable TGF-beta associated with malignancy in thyroid epithelial neoplasia.
Immunogenicity of Del19 EGFR mutations in Chinese patients affected by lung adenocarcinoma.
Immunohistochemical analysis of MIB-1 proliferative activity in human endometrial cancer. Correlation with clinicopathological parameters, patient outcome, retinoblastoma immunoreactivity and K-ras codon 12 point mutations.
Immunohistochemical analysis reveals a protective effect of H-ras expression mediated via apoptosis in node-negative breast cancer patients.
Immunohistochemical and genetic analysis of non-small cell and small cell gallbladder carcinoma and their precursor lesions.
Immunohistochemical and genetic analysis of osteoclastic giant cell tumor of the pancreas.
Immunohistochemical and molecular features of primary clear cell-adenocarcinoma of the rectum, as predictive factors for individualized therapy.
Immunohistochemical detection of RAS, JUN, FOS, and p53 oncoprotein expression in human colorectal adenomas and carcinomas.
Immunohistochemical detection of the H-ras, K-ras, and N-ras oncogenes in squamous cell carcinoma of the head and neck.
Immunohistochemical evaluation of P21ras and P53 proteins expression in human non-small-cell lung cancers.
Immunohistochemical expression of rabphilin-3A-like (Noc2) in normal and tumor tissues of human endocrine pancreas.
Immunohistochemical localization of telomerase hTERT protein and analysis of clonality in multifocal vulvar intraepithelial neoplasia.
Immunohistochemical studies of colorectal cancers that developed following pelvic irradiation.
Immunoperoxidase staining for cytokeratins 8 and 18 is very sensitive for detection of occult node metastasis of colorectal cancer: a comparison with genetic analysis of K-ras.
Immunophenotype and K-RAS mutation in mucinous ovarian adenocarcinoma with mural nodule of high-grade sarcoma: case report.
Immunophenotype of mutant ras p21 and early response to radiotherapy in cancer of the uterine cervix.
Immunophenotype, ras oncogenes and p53 onco-suppressor gene in benzo(a)pyrene induced malignant soft tissue tumours in Wistar rats.
Immunoprevention of Chemical Carcinogenesis through Early Recognition of Oncogene Mutations.
IMP-1 Displays Cross-Talk with K-Ras and Modulates Colon Cancer Cell Survival through the Novel Proapoptotic Protein CYFIP2.
Impact of Cadmium on Intracellular Zinc Levels in HepG2 Cells: Quantitative Evaluations and Molecular Effects.
Impact of garlic organosulfides on p21(H-ras) processing.
Impact of K-Ras Over-expression in Laryngeal Squamous Cell Carcinoma.
Impact of Nrf2 on tumour growth and drug sensitivity in oncogenic K-ras-transformed cells in vitro and in vivo.
Impact of oncogenes in tumor angiogenesis: mutant K-ras up-regulation of vascular endothelial growth factor/vascular permeability factor is necessary, but not sufficient for tumorigenicity of human colorectal carcinoma cells.
Impact of oncogenic driver mutations on feedback between the PI3K and MEK pathways in cancer cells.
Implication of K-ras and p53 in colorectal cancer carcinogenesis in Tunisian population cohort.
Implications and prognostic value of K-ras mutation for early-stage lung cancer in women.
Implications of Rho GTPase Signaling in Glioma Cell Invasion and Tumor Progression.
In silico discovery of small-molecule Ras inhibitors that display antitumor activity by blocking the Ras-effector interaction.
In Systemic Sclerosis, a Unique Long Non Coding RNA Regulates Genes and Pathways Involved in the Three Main Features of the Disease (Vasculopathy, Fibrosis and Autoimmunity) and in Carcinogenesis.
In tumor cells regulation of DNA double strand break repair through EGF receptor involves both NHEJ and HR and is independent of p53 and K-Ras status.
In vitro carcinogenesis of hamster pancreatic duct cells: cellular and molecular alterations.
In vitro pancreatic carcinogenesis.
In vitro transformation of mesenchymal stem cells induces gradual genomic hypomethylation.
In vivo activation of mitogen-activated protein kinases in rat intestinal neoplasia.
In Vivo Activity of Combined PI3K/mTOR and MEK Inhibition in a KrasG12D;Pten Deletion Mouse Model of Ovarian Cancer.
In-silico design of peptide inhibitors of K-Ras target in cancer disease.
In-silico identification of small molecules targeting H-Ras and in-vitro cytotoxicity with caspase-mediated apoptosis in carcinoma cells.
Inactivation of p16INK4a by CpG hypermethylation is not a frequent event in colorectal cancer.
Inactivation of Rab23 inhibits the invasion and motility of pancreatic duct adenocarcinoma.
Inactivation of RASA1 promotes melanoma tumorigenesis via R-Ras activation.
Inactivation of the candidate tumor suppressor par-4 in endometrial cancer.
Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is associated with G to A mutations in K-ras in colorectal tumorigenesis.
Inactivation of the NF1 gene in human melanoma and neuroblastoma cell lines without impaired regulation of GTP.Ras.
Incidence and possible clinical significance of K-ras oncogene activation in adenocarcinoma of the human lung.
Incidence of Harvey ras oncogene point mutations and their expression in methylbenzylnitrosamine-induced esophageal tumorigenesis.
Incidence of P53 and K-ras alterations in ovarian mucinous and serous tumors.
Increase in the frequency of K-ras codon 12 point mutation in colorectal carcinoma in elderly males in Japan: the 1990s compared with the 1960s.
Increased cyclin D1 expression in cancer of the ampulla of Vater: relevance to nuclear beta catenin accumulation and k-ras gene mutation.
Increased epidermal growth factor receptor (EGFR) gene copy number is strongly associated with EGFR mutations and adenocarcinoma in non-small cell lung cancers: a chromogenic in situ hybridization study of 182 patients.
Increased etheno-DNA adducts in affected tissues of patients suffering from Crohn's disease, ulcerative colitis, and chronic pancreatitis.
Increased expression of FoxM1 transcription factor in respiratory epithelium inhibits lung sacculation and causes Clara cell hyperplasia.
Increased farnesyltransferase activity in human colorectal cancer: relationship with clinicopathological features and K-ras mutation.
Increased frequency of K-ras mutations in lung neoplasms from female B6C3F1 mice exposed to ozone for 24 or 30 months.
Increased frequency of the k-ras G12C mutation in MYH polyposis colorectal adenomas.
Increased H-ras mutation frequency in mammary tumors of rats initiated with N-methyl-N-nitrosourea (MNU) and treated with acrylamide.
Increased incidence of squamous cell carcinomas in Mastomys natalensis papillomavirus E6 transgenic mice during two-stage skin carcinogenesis.
Increased K-ras mutation and expression of S100A4 and MUC2 protein in the malignant intraductal papillary mucinous tumor of the pancreas.
Increased Occurrence of Caspase-Dependent Apoptosis in Unfavorable Neuroblastomas.
Increased Rac1 activity and Pak1 overexpression are associated with lymphovascular invasion and lymph node metastasis of upper urinary tract cancer.
Increased radioresistance via G12S K-Ras by compensatory upregulation of MAPK and PI3K pathways in epithelial cancer.
Increased regucalcin gene expression extends survival in breast cancer patients: Overexpression of regucalcin suppresses the proliferation and metastatic bone activity in MDA-MB-231 human breast cancer cells in vitro.
Increased sensitivity of EBNA2-transformed rat fibroblasts to ionizing radiation.
Individual and combined soy isoflavones exert differential effects on metastatic cancer progression.
Individual rac GTPases mediate aspects of prostate cancer cell and bone marrow endothelial cell interactions.
Inducible activation of oncogenic K-ras results in tumor formation in the oral cavity.
Inducible transgenics. New lessons on events governing the induction and commitment in mammary tumorigenesis.
Induction and apoptotic regression of lung adenocarcinomas by regulation of a K-Ras transgene in the presence and absence of tumor suppressor genes.
Induction of apoptosis and inhibition of papilloma formation may signal a new role for okadaic acid.
Induction of CTLs by DCs pulsed with K-ras mutant peptide on the surface of nanoparticles in the treatment of pancreatic cancer.
Induction of different morphologic features of malignant melanoma and pigmented lesions after transformation of murine melanocytes with bFGF-cDNA and H-ras, myc, neu, and E1a oncogenes.
Induction of esophageal tumors in zinc-deficient rats by single low doses of N-nitrosomethylbenzylamine (NMBA): analysis of cell proliferation, and mutations in H-ras and p53 genes.
Induction of invasive mouse skin carcinomas in transgenic mice with mutations in both H-ras and p53.
Induction of invasive squamous cell carcinomas in the forestomach of (C3H x MSM)F1, MSM, and C3H mice by N-methyl-N-nitrosourea and mutational analysis of the H-ras and p53 genes.
Induction of mammary cancer and lymphoma by multiple, low oral doses of 7,12-dimethylbenz[a]anthracene in SENCAR mice.
Induction of ovarian cancer by defined multiple genetic changes in a mouse model system.
Induction of potent cell growth inhibition by schizophyllan/K-ras antisense complex in combination with gemcitabine.
Induction of reactive oxygen species renders mutant and wild-type K-ras pancreatic carcinoma cells susceptible to Ad.mda-7-induced apoptosis.
Induction of the apoptosis inhibitor ARC by Ras in human cancers.
Ineffectiveness of the presence of H-ras/p53 combination of mutations in squamous cell carcinoma cells to induce a conversion of a nontumorigenic to a tumorigenic phenotype.
Influence of retrovirally transduced human tumor-necrosis-factor-alpha on the expression of C-myc, k-ras, C-jun, p53, tgf-alpha, and cea in human colon-carcinoma cell-lines.
Influence of sex and carcinogen treatment protocol on tumor latency and frequency of K-ras mutations in N-methyl-N-nitrosourea-induced lymphomas.
Infrequent activation of K-ras, H-ras, and other oncogenes in hepatocellular neoplasms initiated by methyl(acetoxymethyl)nitrosamine, a methylating agent, and promoted by phenobarbital in F344 rats.
Infrequent involvement of mutations on neurofibromatosis type 1, H-ras, K-ras and N-ras in urothelial tumors.
Infrequent K-ras activation in superficial-type (flat) colorectal adenomas and adenocarcinomas.
Infrequent mutation of the ras genes in skin tumors of xeroderma pigmentosum patients in Japan.
Infrequent RAS oncogene mutations in human prostate cancer.
Ingenuity in pattern recognition: a novel bioinformatics approach towards lung cancer identification.
Inhibiting K-ras Signaling Reserves the Epithelial-Mesenchymal Transition of Pancreatic Cancer Cells and its Mechanisms.
Inhibiting Ras prenylation increases the radiosensitivity of human tumor cell lines with activating mutations of ras oncogenes.
Inhibition effects of Yuxiao San combined with cisplatin on transplanted tumor growths via upregulation of nm-23 and downregulation of K-ras in Lewis lung cancer mice.
Inhibition of a new differentiation pathway in neuroblastoma by copy number defects of N-myc, Cdc42, and nm23 genes.
Inhibition of Calcineurin/NFAT Signaling Blocks Oncogenic H-Ras Induced Autophagy in Primary Human Keratinocytes.
Inhibition of cancer cell invasion by new ((3,4-dihydroxy benzylidene)hydrazinyl)pyridine-3-sulfonamide analogs.
Inhibition of Cdc42 and Rac1 activities in pheochromocytoma, the adrenal medulla tumor.
Inhibition of Cdc42 is essential for Mig-6 suppression of cell migration induced by EGF.
Inhibition of CDC42 reduces macrophage recruitment and suppresses lung tumorigenesis in vivo.
Inhibition of Cdc42-intersectin interaction by small molecule ZCL367 impedes cancer cell cycle progression, proliferation, migration, and tumor growth.
Inhibition of cell proliferation and metastasis of human hepatocellular carcinoma by miR-137 is regulated by CDC42.
Inhibition of chemotherapy-related breast tumor EMT by application of redox-sensitive siRNA delivery system CSO-ss-SA/siRNA along with doxorubicin treatment.
Inhibition of ChoK is an efficient antitumor strategy for Harvey-, Kirsten-, and N-ras-transformed cells.
Inhibition of COX-2 and induction of apoptosis: two determinants of nonsteroidal anti-inflammatory drugs' chemopreventive efficacies in mouse lung tumorigenesis.
Inhibition of cyclooxygenase-2 expression and restoration of gap junction intercellular communication in H-ras-transformed rat liver epithelial cells by caffeic acid phenethyl ester.
Inhibition of de novo Palmitate Synthesis by Fatty Acid Synthase Induces Apoptosis in Tumor Cells by Remodeling Cell Membranes, Inhibiting Signaling Pathways, and Reprogramming Gene Expression.
Inhibition of endothelial cell proliferation by targeting Rac1 GTPase with small interference RNA in tumor cells.
Inhibition of farnesyl protein transferase and P21ras memebrane association by d-limonene in human pancreas tumor cells in vitro.
Inhibition of farnesyltransferase with A-176120, a novel and potent farnesyl pyrophosphate analogue.
Inhibition of fascin in cancer and stromal cells blocks ovarian cancer metastasis.
Inhibition of gastric cancer cell growth and invasion through siRNA-mediated knockdown of guanine nucleotide exchange factor Vav3.
Inhibition of H-ras as a treatment for experimental brain C6 glioma.
Inhibition of H-Ras transformation by the PTEN/MMAC1/TEP1 tumor suppressor gene.
Inhibition of HMGcoA reductase by atorvastatin prevents and reverses MYC-induced lymphomagenesis.
Inhibition of human bladder cancer cell motility by genistein is dependent on epidermal growth factor receptor but not p21ras gene expression.
Inhibition of lung tumor cell growth in vitro and mouse lung tumor formation by lovastatin.
Inhibition of malignant thyroid carcinoma cell proliferation by Ras and galectin-3 inhibitors.
Inhibition of mammalian target of rapamycin reverses alveolar epithelial neoplasia induced by oncogenic K-ras.
Inhibition of MEK pathway in vestibular schwannoma cell culture.
Inhibition of miR-193a Expression by Max and RXR{alpha} Activates K-Ras and PLAU to Mediate Distinct Aspects of Cellular Transformation.
Inhibition of motile and invasive properties of ovarian cancer cells by ASODN against Rho-associated protein kinase.
Inhibition of mutant KRAS-driven overexpression of ARF6 and MYC by an eIF4A inhibitor drug improves the effects of anti-PD-1 immunotherapy for pancreatic cancer.
Inhibition of NRAS Signaling in Melanoma through Direct Depalmitoylation Using Amphiphilic Nucleophiles.
Inhibition of O(6)-methylguanine-DNA methyltransferase increases azoxymethane-induced colonic tumors in rats.
Inhibition of RAC1 activity in cancer associated fibroblasts favours breast tumour development through IL-1? upregulation.
Inhibition of Rac1 GTPase downregulates vascular endothelial growth factor receptor-2 expression by suppressing Sp1-dependent DNA binding in human endothelial cells.
Inhibition of Rac1 reverses enzalutamide resistance in castration-resistant prostate cancer.
Inhibition of RalA signaling pathway in treatment of non-small cell lung cancer.
Inhibition of RAS: proven and potential vulnerabilities.
Inhibition of rat colon tumors by sulindac and sulindac sulfone is independent of K-ras (codon 12) mutation.
Inhibition of redox/Fyn/c-Cbl pathway function by Cdc42 controls tumour initiation capacity and tamoxifen sensitivity in basal-like breast cancer cells.
Inhibition of the membrane localization of p21 ras proteins by lovastatin in tumor cells possessing a mutated N-ras gene.
Inhibition of the miR-192/215-Rab11-FIP2 axis suppresses human gastric cancer progression.
Inhibition of the prenylation of K-Ras, but not H- or N-Ras, is highly resistant to CAAX peptidomimetics and requires both a farnesyltransferase and a geranylgeranyltransferase I inhibitor in human tumor cell lines.
Inhibition of the Rho GTPase, Rac1, decreases estrogen receptor levels and is a novel therapeutic strategy in breast cancer.
Inhibition of tumor cell migration and metastasis by the proton-sensing GPR4 receptor.
Inhibition of tumor growth by S-3-1, a synthetic intermediate of salvianolic acid A.
Inhibitor 9 Combined With Androgen Deprivation Therapy or Chemotherapy Delays the Malignant Behavior of Castration-Resistant Prostate Cancer Through K-Ras/PLC?/PKC? Signaling Pathway.
Inhibitors of chronically active ras: potential for treatment of human malignancies.
Inhibitors of farnesyl protein transferase and MEK1,2 induce apoptosis in fibroblasts transformed with farnesylated but not geranylgeranylated H-Ras.
Inhibitors of K-Ras plasma membrane localization.
Inhibitors of prenyl transferases.
Inhibitors of the ROCK serine/threonine kinases: key effectors of the RhoA small GTPase.
Inhibitory effect of flavonoids on mutant H-Rasp protein.
Inhibitory effect of sarcophytol A on pancreatic carcinogenesis after initiation by N-nitrosobis(2-oxypropyl)amine in Syrian hamsters.
Inhibitory effects of compound DMBT on hypoxia-induced vasculogenic mimicry in human breast cancer.
Inhibitory effects of phenolic alkaloids of menispermum dauricum on gastric cancer in vivo.
Inositol Trisphosphate Receptor Type 3-mediated Enhancement of EGFR and MET Cotargeting Efficacy in Non-Small Cell Lung Cancer Detected by 18F-fluorothymidine.
Insights into oncogenic mutations of plexin-B1 based on the solution structure of the Rho GTPase binding domain.
Insulin like growth factor-1 selectively regulates the expression of matrix metalloproteinase-2 in malignant H-ras transformed cells.
Insulin-like growth factor 1 expression correlates with clinical outcome in K-RAS wild type colorectal cancer patients treated with cetuximab and irinotecan.
Insulin-like growth factor receptor-1 expression predicts postoperative recurrence in adenocarcinoma of the lung.
Insulin-mediated alterations in S-adenosylmethionine decarboxylase expression in H-ras transformed cells of varying degrees of malignancy.
Integrated analysis identifies a long non-coding RNAs-messenger RNAs signature for prediction of prognosis in hepatitis B virus-hepatocellular carcinoma patients.
Integrated genomic and pharmacological approaches to identify synthetic lethal genes as cancer therapeutic targets.
Integration of multiple signaling pathway activities resolves K-RAS/N-RAS mutation paradox in colon epithelial cell response to inflammatory cytokine stimulation.
Integrative genomics identifies RAB23 as an invasion mediator gene in diffuse-type gastric cancer.
Integrative transcriptional analysis between human and mouse cancer cells provides a common set of transformation associated genes.
Integrin trafficking regulated by Rab21 is necessary for cytokinesis.
Integrin-Induced Signal Event Contributes to Self-Assembled Monolayers on Au-Nanoparticle-Regulated Cancer Cell Migration and Invasion.
Integrin?1 modulates tumour resistance to gemcitabine and serves as an independent prognostic factor in pancreatic adenocarcinomas.
Interactions of chemical carcinogens and genetic variation in hepatocellular carcinoma.
Intercellular transfer of oncogenic h-ras at the immunological synapse.
Interferon regulatory factor 3 activates p53-dependent cell growth inhibition.
Interlaboratory comparison of K-ras testing by real-time PCR and RFLP in colorectal cancer samples.
Interleukin-10-deficient mice and inflammatory bowel disease associated cancer development.
Interleukin-6 Prevents the Initiation but Enhances the Progression of Lung Cancer.
Interleukin-6 promotes pancreatic cancer cell migration by rapidly activating the small GTPase CDC42.
International comparison on ras gene mutations in latent prostate carcinoma.
Interplay between menin and K-Ras in regulating lung adenocarcinoma.
Interplay between Rab35 and Arf6 controls cargo recycling to coordinate cell adhesion and recycling.
Interrelationship between the expression of h-ras p21, C-myc and p53 proteins, and the infection of high-risk human papillomaviruses in Japanese patients with esophageal squamous-cell carcinoma.
Interruption of RNA processing machinery by a small compound, 1-[(4-chlorophenyl)methyl]-1H-indole-3-carboxaldehyde (oncrasin-1).
Intervention of human breast cell carcinogenesis chronically induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.
Intracellular expression and functional properties of an anti-p21Ras scFv derived from a rat hybridoma containing specific lambda and irrelevant kappa light chains.
Intracellular expression of an antibody fragment-neutralizing p21 ras promotes tumor regression.
Intracellular HMGB1 as a novel tumor suppressor of pancreatic cancer.
Intracellular redox regulation by the family of small GTPases.
Intraductal papillary-mucinous tumours represent a distinct group of pancreatic neoplasms: an investigation of tumour cell differentiation and K-ras, p53 and c-erbB-2 abnormalities in 26 patients.
Intraductal Tubulopapillary Epithelial Proliferation Associated with Type 1 Autoimmune Pancreatitis.
Intratumor cellular heterogeneity and alterations in ras oncogene and p53 tumor suppressor gene in human prostate carcinoma.
Intratumor genetic heterogeneity in advanced human colorectal adenocarcinoma.
Intratumor heterogeneity of k-ras and p53 mutations among human colorectal adenomas containing early cancer.
Intravenous infusion of bone marrow mononuclear cells promotes functional recovery and improves impaired cognitive function via inhibition of Rho guanine nucleotide triphosphatases and inflammatory signals in a model of chronic epilepsy.
Intrinsic K-Ras dynamics: A novel molecular dynamics data analysis method shows causality between residue pair motions.
Introduction of wild-type p53 gene downregulates the expression of H-ras gene and suppresses the growth of bladder cancer cells.
Invasion inhibition in pancreatic cancer using the oral iron chelating agent deferasirox.
Invasive cancer and survival of intraductal papillary mucinous tumors of the pancreas.
Inverse relationship between microsatellite instability and K-ras and p53 gene alterations in colon cancer.
Investigating the role of ADP-ribosylation factor 6 in tumor cell invasion and extracellular signal-regulated kinase activation.
Investigation of c-myc and K-ras amplification in renal clear cell adenocarcinoma.
Investigation of GTP-dependent dimerization of G12X K-Ras variants using ultraviolet photodissociation mass spectrometry.
Investigation of the pharmacological profiles of dinuclear metal complexes as novel, potent and selective cytotoxic agents against ras-transformed cells.
Involvement of E-cadherin, beta-catenin, Cdc42 and CXCR4 in the progression and prognosis of cutaneous melanoma.
Involvement of K-RAS mutations and amino acid substitutions in the survival of metastatic colorectal cancer patients.
Involvement of Kruppel-like factor 6 (KLF6) mutation in the development of nonpolypoid colorectal carcinoma.
Involvement of Rho family GTPases in p19Arf- and p53-mediated proliferation of primary mouse embryonic fibroblasts.
Involvement of small ArfGAP1 (SMAP1), a novel Arf6-specific GTPase-activating protein, in microsatellite instability oncogenesis.
Involvement of TMEM22 overexpression in the growth of renal cell carcinoma cells.
IQGAP1 regulates cell proliferation through a novel CDC42-mTOR pathway.
IQGAPs in Cancer: A Family of Scaffold Proteins Underlying Tumorigenesis.
Irinotecan hydrochloride (CPT-11) resistance identified by K-ras mutation in patients with progressive colon cancer after treatment with 5-fluorouracil (5-FU).
IRSp53 coordinates AMPK and 14-3-3 signaling to regulate filopodia dynamics and directed cell migration.
Is autotaxin (ENPP2) the link between hepatitis C and hepatocellular cancer?
Is availability of anti-EGFR therapy for the colorectal adenocarcinomas showing fascin expression limited?
Is primary sidedness a prognostic factor in patients with resected colon cancer liver metastases (CLM)?
Is the Effect of Tumor Localization on Prognosis Compatible with Real-life Data in Metastatic Colon Cancer? Single-Center Experience: A Retrospective Analysis.
Ischemia-induced K-ras mutations in human colorectal cancer cells: role of microenvironmental regulation of MSH2 expression.
Isoform specific gene expression analysis of KRAS in the prognosis of lung adenocarcinoma patients.
Isogambogenic acid inhibits tumour angiogenesis by suppressing Rho GTPases and vascular endothelial growth factor receptor 2 signalling pathway.
Isolated Hepatic Perfusion with High-Dose Melphalan Results in Immediate Alterations in Tumor Gene Expression in Patients with Metastatic Ocular Melanoma.
Isolation of a chemical inhibitor against K-Ras-induced p53 suppression through natural compound screening.
Isolation of mutations in the Drosophila homologues of the human Neurofibromatosis 2 and yeast CDC42 genes using a simple and efficient reverse-genetic method.
K-ras 4A and 4B are co-expressed widely in human tissues, and their ratio is altered in sporadic colorectal cancer.
K-ras 4A and 4B mRNA levels correlate with superoxide in lung adenocarcinoma cells, while at the protein level, only mutant K-ras 4A protein correlates with superoxide.
K-ras activation and ras p21 expression in latent prostatic carcinoma in Japanese men.
K-ras activation generates an inflammatory response in lung tumors.
K-ras activation in gastric epithelial tumors in Japanese.
K-ras activation in neoplasms of the human female reproductive tract.
K-ras activation in non-small cell lung cancer in the dog.
K-ras activation in premalignant and malignant epithelial lesions of the human uterus.
K-ras activation occurs frequently in mucinous adenocarcinomas and rarely in other common epithelial tumors of the human ovary.
K-ras alterations in Danish ovarian tumour patients. From the Danish "Malova" Ovarian Cancer study.
K-ras and B-raf gene mutations are not associated with gastrin- and CCK2-receptor mRNA expression in human colorectal tumour tissues.
K-Ras and cyclooxygenase-2 coactivation augments intraductal papillary mucinous neoplasm and Notch1 mimicking human pancreas lesions.
K-ras and Dpc4 mutations in chronic pancreatitis: case series.
K-Ras and its inhibitors towards personalized cancer treatment: Pharmacological and structural perspectives.
K-Ras and microsatellite marker analysis of fine-needle aspirates from intraductal papillary mucinous neoplasms of the pancreas.
K-RAS and N-RAS mutations in testicular germ cell tumors.
K-ras and p16 aberrations confer poor prognosis in human colorectal cancer.
K-ras and p16(INK4A)alterations in sputum of NSCLC patients and in heavy asymptomatic chronic smokers.
K-ras and p53 gene mutations in colorectal cancer in 57 Japanese patients.
K-ras and p53 gene mutations in pancreatic cancer: ductal and nonductal tumors progress through different genetic lesions.
K-ras and p53 in pancreatic cancer: association with medical history, histopathology, and environmental exposures in a population-based study.
K-ras and p53 mutations and overexpressions as prognostic factors in female rectal carcinoma.
K-ras and p53 mutations in aberrant crypt foci and colonic tumors from colon cancer patients.
K-RAS and P53 mutations in association with COX-2 and hTERT expression and clinico-pathological status of NSCLC patients.
K-ras and p53 mutations in colonic lavage fluid of patients with colorectal neoplasias.
K-ras and p53 mutations in DNA extracted from colonic epithelial cells exfoliated in faeces of patients with colorectal cancer.
K-ras and p53 mutations in hamster pancreatic ductal adenocarcinomas and cell lines.
K-ras and p53 mutations in hereditary non-polyposis colorectal cancers.
K-ras and p53 mutations in stage I gallbladder carcinoma with an anomalous junction of the pancreaticobiliary duct.
K-ras and p53 mutations in the pathogenesis of classical and goblet cell carcinoids of the appendix.
K-ras and p53 point mutations in 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced hamster lung tumors.
K-ras and rho A mutations in malignant pleural effusion.
K-ras as a target for cancer therapy.
K-ras as a target for lung cancer therapy.
K-ras Asp12 mutant neither interacts with Raf, nor signals through Erk and is less tumorigenic than K-ras Val12.
K-ras cancer gene mutations in lung tumors from female Swiss (CD-1) mice exposed transplacentally to 3'-azido-3'-deoxythymidine.
K-ras codon 12 and 13 mutations are correlated with differential patterns of tumor cell dissemination in colorectal cancer patients.
K-ras codon 12 and 61 point mutations in bromodeoxyuridine- and N-nitrosomethylurea-induced rat renal mesenchymal tumors.
K-ras codon 12 and p53 mutations in biopsy specimens and bile from biliary tract cancers.
K-ras codon 12 mutation determines the polypoid growth of colorectral cancer.
K-ras codon 12 mutation induces higher level of resistance to apoptosis and predisposition to anchorage-independent growth than codon 13 mutation or proto-oncogene overexpression.
K-ras codon 12 mutations detected with enriched PCR method in operable non-small cell lung cancer.
K-ras codon 12 mutations in biliary tract tumors detected by polymerase chain reaction denaturing gradient gel electrophoresis.
K-ras codon 12 mutations may be detected in serum of patients suffering from adeno- and large cell lung carcinoma. A preliminary report.
K-ras codon 12 mutations of the super-minute dysplasia in Barrett's esophagus by DNA extraction using a microdissection method.
K-ras exon 2 point mutations in human endometrial cancer.
K-ras exon 4A has a tumour suppressor effect on carcinogen-induced murine colonic adenoma formation.
K-ras expression--marker of dysplasia and cancer.
K-ras gene mutation as a pathogenetic and diagnostic marker in human cancer.
K-ras gene mutation as an early prognostic marker of colon cancer.
K-ras gene mutation enhances motility of immortalized airway cells and lung adenocarcinoma cells via Akt activation: possible contribution to non-invasive expansion of lung adenocarcinoma.
K-ras gene mutation in the diagnosis of ultrasound guided fine-needle biopsy of pancreatic masses.
K-Ras gene mutation status as a prognostic and predictive factor in patients with colorectal cancer undergoing irinotecan- or oxaliplatin-based chemotherapy.
K-ras gene mutational analysis supports a monoclonal origin of biphasic pleomorphic carcinoma of the lung.
K-ras gene mutations and loss of heterozygosity at the p53 gene locus relative to histological characteristics of mucin-producing tumors of the pancreas.
K-ras gene mutations in early colorectal cancer ... flat elevated vs polyp-forming cancer....
K-ras gene mutations in intrahepatic bile duct tumors of Syrian golden hamsters.
K-ras gene mutations in normal colorectal tissues from K-ras mutation-positive colorectal cancer patients.
K-ras gene mutations: an unfavorable prognostic marker in stage I lung adenocarcinoma.
K-ras gene point mutation: a stable tumor marker in non-small cell lung carcinoma.
K-ras gene point mutations and p21ras immunostaining in human ovarian tumors.
K-ras gene point mutations in human endometrial carcinomas: correlation with clinicopathological features and patients' outcome.
K-ras genetic mutation and influencing factor analysis for Han and Uygur nationality colorectal cancer patients.
K-ras genotypes and prognosis in non-small-cell lung cancer.
K-Ras mediated murine epidermal tumorigenesis is dependent upon and associated with elevated Rac1 activity.
K-RAS Mutant Gene Found in Pancreatic Juice Activated Chromatin From Peri-ampullary Adenocarcinomas.
K-RAS Mutant Pancreatic Tumors Show Higher Sensitivity to MEK than to PI3K Inhibition In Vivo.
K-RAS mutation analysis in a case of pancreatic cystic tumour: an additional tool in making decision of surgical management.
K-Ras mutation and amplification status is predictive of resistance and high basal pAKT is predictive of sensitivity to everolimus in biliary tract cancer cell lines.
K-ras mutation and loss of heterozygosity of chromosome 17p and survival in colorectal cancer.
K-ras mutation and loss of heterozygosity of the adenomatous polyposis coli gene in patients with colorectal adenomas with in situ carcinoma.
k-ras mutation and occupational asbestos exposure in lung adenocarcinoma: asbestos-related cancer without asbestosis.
K-ras mutation and p53 protein accumulation in intraductal mucin-hypersecreting neoplasms of the pancreas.
k-RAS mutation and resistance to epidermal growth factor receptor-tyrosine kinase inhibitor treatment in patients with nonsmall cell lung cancer.
K-ras mutation detection by hybridization to a polypyrrole DNA chip.
K-ras mutation detection in colorectal cancer using the Pyrosequencing technique.
K-Ras mutation detection in liquid biopsy and tumor tissue as prognostic biomarker in patients with pancreatic cancer: a systematic review with meta-analysis.
K-ras mutation in a tubular adenoma originating at an ileostomy in a familial adenomatous polyposis patient.
K-ras mutation in adenomas and carcinomas of the ampulla of vater.
K-ras mutation in colorectal cancer: relations to patient age, sex and tumour location.
K-ras mutation in colorectal carcinomas from singapore.
K-ras mutation in Greek patients with poorly and moderately differenciated tumours of the lower intestinal tract.
K-ras mutation in helicobacter pylori-associated chronic gastritis in patients with and without gastric cancer.
K-Ras mutation in liquid biopsy and tumor tissue correlation in patients with pancreatic cancer.
K-RAS mutation in the screening, prognosis and treatment of cancer.
K-RAS mutation in the tumour of Ferrante I of Aragon, King of Naples.
K-ras mutation influences macroscopic features of gastric carcinoma.
k-ras mutation may be an early event in mucinous ovarian tumorigenesis.
K-RAS mutation profile in Puerto Rican patients with colorectal cancer: trends from April 2009 to January 2011.
K-ras mutation promotes ionizing radiation-induced invasion and migration of lung cancer in part via the Cathepsin L/CUX1 pathway.
K-ras mutation status correlates with the expression of VEGFR1, VEGFR2, and PDGFRalpha in colorectal cancer.
K-ras Mutation Targeted to Gastric Tissue Progenitor Cells Results in Chronic Inflammation, an Altered Microenvironment, and Progression to Intraepithelial Neoplasia.
K-ras mutation, p53 overexpression, and microsatellite instability in biliary tract cancers: a population-based study in China.
K-ras mutation: early detection in molecular diagnosis and risk assessment of colorectal, pancreas, and lung cancers--a review.
K-ras mutational analysis of polyclonal colorectal cancers identifies uniclonal circulating tumor cells.
K-ras mutational status predicts poor prognosis in unresectable pancreatic cancer.
K-ras mutations (codon 12) are not involved in down-regulation of MHC class-I genes in colon carcinomas.
K-ras mutations and benefit from cetuximab in advanced colorectal cancer.
K-ras mutations and cell kinetics in Helicobacter pylori associated gastric intestinal metaplasia: a comparison before and after eradication in patients with chronic gastritis and gastric cancer.
K-ras mutations and HPV infection in cervicitis and intraepithelial neoplasias of the cervix.
K-ras mutations and mucin profile in preneoplastic lesions and colon tumors induced in rats by 1,2-dimethylhydrazine.
K-ras mutations and p53 alterations in neoplastic and nonneoplastic lesions associated with longstanding ulcerative colitis.
K-ras mutations and prognosis in large-bowel carcinomas.
K-ras mutations and RASSF1A promoter methylation in colorectal cancer.
K-Ras mutations and treatment outcome in colorectal cancer patients receiving exclusive fluoropyrimidine therapy.
K-ras mutations appear in the premalignant phase of both microsatellite stable and unstable endometrial carcinogenesis.
K-ras mutations are a relatively late event in the pathogenesis of lung carcinomas.
K-ras mutations are correlated to lymph node metastasis and tumor stage, but not to the growth pattern of colon carcinoma.
K-ras mutations are found in DNA extracted from the plasma of patients with colorectal cancer.
K-ras mutations are frequent in pulmonary squamous cell carcinomas but not in adenocarcinomas of WBN/Kob rats induced by N-nitrosobis(2-oxopropyl)amine.
K-ras Mutations Correlate with Atypical Cytology and Elevated CEA Levels in Pancreatic Cystic Neoplasms.
K-ras mutations in 1,2-dimethylhydrazine-induced colonic tumors: effects of supplemental dietary calcium and vitamin D deficiency.
K-ras mutations in 239PuO2 canine lung neoplasms.
K-ras mutations in benzotrichloride-induced lung tumors of A/J mice.
K-ras mutations in colorectal adenocarcinomas and neighbouring transitional mucosa.
K-ras mutations in colorectal cancer: a practice changing discovery.
K-ras mutations in DNA extracted from the plasma of patients with pancreatic carcinoma: diagnostic utility and prognostic significance.
K-ras mutations in duodenal aspirate without secretin stimulation for screening of pancreatic and biliary tract carcinoma.
K-ras mutations in endometrial carcinomas with microsatellite instability.
K-ras mutations in gastric stump carcinomas and in carcinomas from the non-operated stomach.
K-ras mutations in human adenocarcinoma of the lung: association with smoking and occupational exposure to asbestos.
K-ras mutations in lung carcinomas from nonsmoking women exposed to unvented coal smoke in China.
K-ras mutations in lung tumors and tumors from other organs are consistent with a common mechanism of ethylene oxide tumorigenesis in the B6C3F1 mouse.
K-ras mutations in lung tumors from A/J and A/J x TSG-p53 F1 mice treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and phenethyl isothiocyanate.
K-ras Mutations in Lung Tumors from NNK-treated Mice with Lipopolysaccharide-elicited Lung Inflammation.
K-ras mutations in lung tumors from p53 mutant mice exposed to cigarette smoke.
K-ras mutations in Müllerian inclusion cysts associated with serous borderline tumors of the ovary.
K-ras mutations in mouse lung tumors of extreme age: independent of paternal preconceptional exposure to chromium(III) but significantly more frequent in carcinomas than adenomas.
K-ras mutations in mucinous ovarian tumors: a clinicopathologic and molecular study of 95 cases.
K-ras mutations in non-small-cell lung carcinoma: a review.
K-ras mutations in nonmucinous ovarian epithelial tumors: a molecular analysis and clinicopathologic study of 144 patients.
K-RAS mutations in ovarian and extraovarian lesions of serous tumors of borderline malignancy.
K-ras mutations in patients with early colorectal cancers.
K-ras mutations in sera of patients with colorectal neoplasias and long-standing inflammatory bowel disease.
K-ras mutations in sinonasal adenocarcinomas in patients occupationally exposed to wood or leather dust.
K-ras mutations in sinonasal cancers in relation to wood dust exposure.
K-ras mutations in stools and tissue samples from patients with malignant and nonmalignant pancreatic diseases.
K-ras mutations in the bile of patients with primary sclerosing cholangitis.
K-ras mutations in the duodenal fluid of patients with pancreatic carcinoma.
K-ras mutations in tissue and stool samples from patients with pancreatic cancer and chronic pancreatitis.
K-ras mutations, rectal crypt cells proliferation, and meat consumption in patients with left-sided colorectal carcinoma.
K-ras oncogene activation as a prognostic marker in adenocarcinoma of the lung.
K-ras oncogene activation in adenocarcinoma of the human pancreas. A study of 82 carcinomas using a combination of mutant-enriched polymerase chain reaction analysis and allele-specific oligonucleotide hybridization.
K-ras oncogene mutation in cancer and precancerous lesions of the gallbladder.
K-ras oncogene mutations in neoplasias of kidney transplanted patients: preliminary results with a new technique.
K-ras oncogene mutations in osteoclast-like giant cell tumors of the pancreas and liver: genetic evidence to support origin from the duct epithelium.
K-ras oncogene mutations in rat colon tumors induced by N-methyl-N-nitrosourea.
K-ras oncogene mutations in sporadic colorectal cancer in The Netherlands Cohort Study.
K-ras oncogene mutations indicate malignancy in cystic tumors of the pancreas.
K-ras oncogene silencing strategy reduces tumor growth and enhances gemcitabine chemotherapy efficacy for pancreatic cancer treatment.
K-ras p21 expression and activity in lung and lung tumors.
K-ras point mutation in the nerve plexuses around the superior mesenteric artery in resectable adenocarcinoma of the pancreatic head: distribution pattern and related factors.
K-ras point mutation is associated with enhancement by deoxycholic acid of colon carcinogenesis induced by azoxymethane, but not with its attenuation by all-trans-retinoic acid.
K-RAS point mutation, and amplification of C-MYC and C-ERBB2 in colon adenocarcinoma.
K-ras point mutations in endometrial carcinoma: effect on outcome is dependent on age of patient.
K-ras point mutations in human colorectal carcinomas: relation to aneuploidy and metastasis.
K-ras point mutations in spontaneously occurring endometrial adenocarcinomas in the Donryu rat.
K-ras point mutations in the supernatants of pancreatic juice and bile are reliable for diagnosis of pancreas and biliary tract carcinomas complementary to cytologic examination.
K-Ras prenylation as a potential anticancer target.
K-Ras promotes angiogenesis mediated by immortalized human pancreatic epithelial cells through mitogen-activated protein kinase signaling pathways.
K-Ras Promotes Tumorigenicity through Suppression of Non-canonical Wnt Signaling.
K-Ras protein as a drug target.
K-ras proto-oncogene exhibits tumor suppressor activity as its absence promotes tumorigenesis in murine teratomas.
K-ras role in lung cancer therapy.
K-ras status does not predict successful hepatic resection of colorectal cancer metastasis.
K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions.
K-Ras(G12D)-selective inhibitory peptides generated by random peptide T7 phage display technology.
K-RAS(V12) induces autocrine production of EGFR ligands and mediates radioresistance through EGFR-dependent Akt signaling and activation of DNA-PKcs.
K-Ras(V14I) -induced Noonan syndrome predisposes to tumour development in mice.
K-Ras, H-Ras, N-Ras and B-Raf mutation and expression analysis in Wilms tumors: association with tumor growth.
K-Ras-Activated Cells Can Develop into Lung Tumors When Runx3-Mediated Tumor Suppressor Pathways Are Abrogated.
K-RasG12D Has a Potential Allosteric Small Molecule Binding Site.
K-rasG12V mediated lung tumor models identified three new quantitative trait loci modifying events post-K-ras mutation.
Kallikrein 6 protease advances colon tumorigenesis via induction of the high mobility group A2 protein.
Keratin 20 is a specific marker of submicroscopic lymph node metastases in colorectal cancer: validation by K-RAS mutations.
Killer genes in pancreatic cancer therapy.
Kinase-dependent and -independent roles of EphA2 in the regulation of prostate cancer invasion and metastasis.
Kinetics of O(6)()-Methyl-2'-deoxyguanosine Repair by O(6)()-Alkylguanine DNA Alkyltransferase within K-ras Gene-Derived DNA Sequences.
Kirsten Ras* oncogene: Significance of its discovery in human cancer research.
KLF4 regulates adult lung tumor-initiating cells and represses K-Ras-mediated lung cancer.
KLF4 Suppresses Tumor Formation in Genetic and Pharmacological Mouse Models of Colonic Tumorigenesis.
Knock-in of mutant K-ras in nontumorigenic human epithelial cells as a new model for studying K-ras mediated transformation.
Knockdown of Arf6 increases drug sensitivity and inhibits proliferation, migration and invasion in gastric cancer SGC-7901 cells.
Knockdown of Rab21 inhibits proliferation and induces apoptosis in human glioma cells.
KRAS and BRAF mutations in ovarian tumors: a comprehensive study of invasive carcinomas, borderline tumors and extraovarian implants.
KRAS insertion mutations are oncogenic and exhibit distinct functional properties.
KRAS mutant colorectal tumors: past and present.
KRAS mutant NSCLC, a new opportunity for the synthetic lethality therapeutic approach.
KRAS Mutation Testing of Colorectal Cancer for Anti-EGFR Therapy: Dogmas versus Evidence.
KRAS: From undruggable to a druggable Cancer Target.
Krüppel-like factor 8 promotes tumorigenic mammary stem cell induction by targeting miR-146a.
Lack of elevated MAP kinase (Erk) activity in pancreatic carcinomas despite oncogenic K-ras expression.
Lack of mutations in K-ras codons 12 and 13 in human atherosclerotic lesions.
Lack of p53 and ras mutations in Helicobacter hepaticus-induced liver tumors in A/JCr mice.
Lack of prognostic significance of p53 and K-ras mutations in primary resected non-small-cell lung cancer on E4592: a Laboratory Ancillary Study on an Eastern Cooperative Oncology Group Prospective Randomized Trial of Postoperative Adjuvant Therapy.
Large oncosomes in human prostate cancer tissues and in the circulation of mice with metastatic disease.
LATS2 tumour specific mutations and down-regulation of the gene in non-small cell carcinoma.
Lentivirus-mediated carboxyl-terminal modulator protein gene transfection via aerosol in lungs of K-ras null mice.
Lessons from the genetics of colon cancer.
Let-7 microRNA transfer in pancreatic cancer-derived cells inhibits in vitro cell proliferation but fails to alter tumor progression.
Let-7c functions as a metastasis suppressor by targeting MMP11 and PBX3 in colorectal cancer.
Leukemia-associated NOTCH1 alleles are weak tumor initiators but accelerate K-ras-initiated leukemia.
Leukemoid reaction in a patient with adenocarcinoma of the lung: a case report.
Levels and membrane localization of the c-K-ras p21 protein in lungs of mice of different genetic strains and effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and Aroclor 1254.
Levels of 4-aminobiphenyl-induced somatic H-ras mutation in mouse liver DNA correlate with potential for liver tumor development.
Life-span inhalation exposure to mainstream cigarette smoke induces lung cancer in B6C3F1 mice through genetic and epigenetic pathways.
Lifetime history of alcohol consumption and K-ras mutations in pancreatic ductal adenocarcinoma.
Lignan precursors from flaxseed or rye bran do not protect against the development of intestinal neoplasia in ApcMin mice.
Limonene chemoprevention of mammary carcinoma induction following direct in situ transfer of v-Ha-ras.
Lin28 promotes transformation and is associated with advanced human malignancies.
Lin28-let7 modulates radiosensitivity of human cancer cells with activation of K-Ras.
lincRNA-RoR and miR-145 regulate invasion in triple-negative breast cancer via targeting ARF6.
Lipid and sulfur substituted prenylcysteine analogs as human Icmt inhibitors.
Liposome-mediated in vivo gene transfer of antisense K-ras construct inhibits pancreatic tumor dissemination in the murine peritoneal cavity.
Live cell imaging of RhoGTPase biosensors in tumor cells.
Liver tumors induced in B6C3F1 mice by 7-chlorobenz[a]anthracene and 7-bromobenz[a]anthracene contain K-ras protooncogene mutations.
lncRNA OSER1-AS1 acts as a ceRNA to promote tumorigenesis in hepatocellular carcinoma by regulating miR-372-3p/Rab23 axis.
lncRNA UCA1-Mediated Cdc42 Signaling Promotes Oncolytic Vaccinia Virus Cell-to-Cell Spread in Ovarian Cancer.
Localization of H-ras mRNA in oral squamous cell carcinomas.
Localization of IQGAP1 is inversely correlated with intercellular adhesion mediated by e-cadherin in gastric cancers.
Localized Rho GTPase activation regulates RNA dynamics and compartmentalization in tumor cell protrusions.
Long non-coding RNA NEAT1 promotes tumor development and metastasis through targeting RAB9A in malignant melanoma.
Long Noncoding RNA LUADT1 Is Upregulated in Melanoma and May Sponge miR-28-5p to Upregulate RAP1B.
Long-term follow-up of patients with a clinically benign extrahepatic biliary stenosis and K-ras mutation in endobiliary brush cytology.
Loss of a c-H-ras-1 allele and aggressive human primary breast carcinomas.
Loss of a reporter gene for green fluorescent protein during tumor progression suggests the recruitment of host cells in rats with experimentally induced colon cancer.
Loss of Apc allows phenotypic manifestation of the transforming properties of an endogenous K-ras oncogene in vivo.
Loss of Apc and the entire chromosome 18 but absence of mutations at the Ras and Tp53 genes in intestinal tumors from Apc1638N, a mouse model for Apc-driven carcinogenesis.
Loss of CDX2 expression and microsatellite instability are prominent features of large cell minimally differentiated carcinomas of the colon.
Loss of desmocollin 3 in skin tumor development and progression.
Loss of Fhit expression in non-small-cell lung cancer: correlation with molecular genetic abnormalities and clinicopathological features.
Loss of giant obscurins from breast epithelium promotes epithelial-to-mesenchymal transition, tumorigenicity and metastasis.
Loss of growth control by TGF-beta occurs at a late stage of mouse skin carcinogenesis and is independent of ras gene activation.
Loss of heterozygosity and K-ras gene mutations in gastric cancer.
Loss of heterozygosity and microsatellite instability of the h-ras gene in cancer of the head and neck.
Loss of heterozygosity at the human RAP1A/Krev-1 locus is a rare event in colorectal tumors.
Loss of heterozygosity on the short arm of chromosome 3 in carcinoma of the uterine cervix.
Loss of p53 cooperates with K-ras activation to induce glioma formation in a region-independent manner.
Loss of RASSF2 Enhances Tumorigencity of Lung Cancer Cells and Confers Resistance to Chemotherapy.
Lovastatin induces apoptosis of k-ras-transformed thyroid cells via inhibition of ras farnesylation and by modulating redox state.
Lovastatin, a cholesterol biosynthesis inhibitor, inhibits the growth of human H-ras oncogene transformed cells in nude mice.
Low correspondence between K-ras mutations in pancreatic cancer tissue and detection of K-ras mutations in circulating DNA.
Low frequency of BRAF and CDKN2A mutations in endometrial cancer.
Low frequency of H-ras activation in naturally occurring hepatocellular tumors of C3H/HeNCr mice.
Low frequency of H-ras mutations in hepatocellular adenomas and carcinomas and in hepatoblastomas from B6C3F1 mice exposed to oxazepam in the diet.
Low frequency of p53 and k-ras codon 12 mutations in non-small cell lung carcinoma (NSCLC) tumors and surgical margins.
Low frequency of TERT promoter mutations in a series of well-differentiated follicular-patterned thyroid neoplasms.
Low level of microsatellite instability in paediatric malignant astrocytomas.
Low mutational rate of K-ras codon 12 in singular bronchoscopy specimens in suspected lung cancer.
Low O6-alkylguanine DNA-alkyltransferase activity in normal colorectal tissue is associated with colorectal tumours containing a GC-->AT transition in the K-ras oncogene.
Low-dose metronomic cyclophosphamide treatment mediates ischemia-dependent K-ras mutation in colorectal carcinoma xenografts.
Low-intensity continuous ultrasound triggers effective bisphosphonate anticancer activity in breast cancer.
Low-level microsatellite instability in most colorectal carcinomas.
Lower incidence of K-ras codon 12 mutation in flat colorectal adenomas than in polypoid adenomas.
LRRC4 inhibits glioma cell growth and invasion through a miR-185-dependent pathway.
Lung cancer and past occupational exposure to asbestos. Role of p53 and K-ras mutations.
Lung tumor induced by long-term inhalation or intratracheal instillation of diesel exhaust particles.
Lung-targeted expression of the c-Raf-1 kinase in transgenic mice exposes a novel oncogenic character of the wild-type protein.
Lysosomal trafficking mediated by Arl8b and BORC promotes invasion of cancer cells that survive radiation.
M-Ras induces Ral and JNK activation to regulate MEK/ERK-independent gene expression in MCF-7 breast cancer cells.
Machine Learning Helps Identify New Drug Mechanisms in Triple-Negative Breast Cancer.
Machineries regulating the activity of the small GTPase Arf6 in cancer cells are potential targets for developing innovative anti-cancer drugs.
Macropinocytosis of the PDGF ?-receptor promotes fibroblast transformation by H-RasG12V.
Macropinocytosis, mTORC1 and cellular growth control.
Maintenance BEZ235 Treatment Prolongs the Therapeutic Effect of the Combination of BEZ235 and Radiotherapy for Colorectal Cancer.
Major oncogenes and tumor suppressor genes involved in epithelial ovarian cancer (review).
Malignant activation of a K-ras oncogene in lung carcinoma but not in normal tissue of the same patient.
Malignant fibrous histiocytoma of the pancreas: a case report with genetic analysis.
Malignant transformation of a mouse liver epithelial cell line by transfection of an activated c-H-ras gene with a point mutation at codon 12.
Malignant transformation of an epithelial cell by v-Src via tv-a-mediated retroviral infection: a new cell model for studying carcinogenesis.
Malignant transformation of duct-like cells originating from acini in transforming growth factor transgenic mice.
MALT1 is required for EGFR-induced NF-?B activation and contributes to EGFR-driven lung cancer progression.
Mammalian target of rapamycin activator RHEB is frequently overexpressed in human carcinomas and is critical and sufficient for skin epithelial carcinogenesis.
Mammosomatotroph adenoma causing gigantism in an 8-year old boy: a possible pathogenetic mechanism.
Map kinase activation correlates with K-ras mutation and loss of heterozygosity on chromosome 6 in alveolar bronchiolar carcinomas from B6C3F1 mice exposed to vanadium pentoxide for 2 years.
MAP kinase and autophagy pathways cooperate to maintain RAS mutant cancer cell survival.
Mapping the Conformation Space of Wildtype and Mutant H-Ras with a Memetic, Cellular, and Multiscale Evolutionary Algorithm.
Maspin controls mammary tumor cell migration through inhibiting Rac1 and Cdc42, but not the RhoA GTPase.
Matrix metalloproteinase?2 regulates MDA?MB?231 breast cancer cell invasion induced by active mammalian diaphanous-related formin 1.
MCAM is a novel metastasis marker and regulates spreading, apoptosis and invasion of ovarian cancer cells.
Meat consumption and K-ras mutations in sporadic colon and rectal cancer in The Netherlands Cohort Study.
Mechanism of Akt1 inhibition of breast cancer cell invasion reveals a protumorigenic role for TSC2.
Mechanism of H-ras oncogene activation in mouse squamous carcinoma induced by an alkylating agent.
Mechanisms of aflatoxin B1 lung tumorigenesis.
Mechanisms of cancer inhibition by anti-oxidant nutrients.
Mechanistic Differences of Activation of Rac1P29S and Rac1A159V.
Medicinal Chemistry and Pharmacology Focused on Cannabidiol, a Major Component of the Fiber-Type Cannabis.
Meet me in the cytoplasm: A role for p27(Kip1) in the control of H-Ras.
MEK inhibition suppresses K-Ras wild-type cholangiocarcinoma in vitro and in vivo via inhibiting cell proliferation and modulating tumor microenvironment.
MEK1/2 inhibitors AS703026 and AZD6244 may be potential therapies for KRAS mutated colorectal cancer that is resistant to EGFR monoclonal antibody therapy.
Melanoma chondroitin sulphate proteoglycan regulates cell spreading through Cdc42, Ack-1 and p130cas.
Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET.
Melanoma-released exosomes directly activate the mitochondrial apoptotic pathway of CD4+ T cells through their microRNA cargo.
Melphalan inhibits adenoma development through modulating the expression of K-ras-specific markers in K-ras Tg mice.
Melting temperature analysis as quantitative method for detection of point mutations.
Membrane curvature sensing of the lipid-anchored K-Ras small GTPase.
Memory T cells of a patient with follicular thyroid carcinoma recognize peptides derived from mutated p21 ras (Gln-->Leu61).
Menin determines K-RAS proliferative outputs in endocrine cells.
MERTK as a novel therapeutic target in head and neck cancer.
Metabolic plasticity in heterogeneous pancreatic ductal adenocarcinoma.
Metabolic profiling of gemcitabine- and paclitaxel-treated immortalized human pancreatic cell lines with K-RAS
Metabolic remodeling of the tumor microenvironment: Migration stimulating factor (MSF) reprograms myofibroblasts toward lactate production, fueling anabolic tumor growth.
Metastasis is driven by sequential elevation of H-ras and Smad2 levels.
Metastatic MHC class I-negative mouse cells derived by transformation with human papillomavirus type 16.
Metformin impairs Rho GTPase signaling to induce apoptosis in neuroblastoma cells and inhibits growth of tumors in the xenograft mouse model of neuroblastoma.
Methionine represses the autophagy of gastric cancer stem cells via promoting the methylation and phosphorylation of RAB37.
Methylation associated inactivation of RASSF1A and its synergistic effect with activated K-Ras in nasopharyngeal carcinoma.
Methylation of estrogen receptor 1 in colorectal adenomas is not age-dependent, but is correlated with K-ras mutation.
Methylation of O(6)-methylguanine-DNA methyltransferase gene is associated significantly with K-ras mutation, lymph node invasion, tumor staging, and disease free survival in patients with gastric carcinoma.
Methylation of O-6-methylguanine DNA methyltransferase characterizes a subset of colorectal cancer with low-level DNA microsatellite instability.
Methylation patterns and K-ras mutations in tumor and paired serum of resected non-small-cell lung cancer patients.
METTL3 regulates the malignancy of cervical cancer via post-transcriptional regulation of RAB2B.
Mevalonate Blockade in Cancer Cells Triggers CLEC9A+ Dendritic Cell-Mediated Antitumor Immunity.
Mice defective in the DNA mismatch gene PMS2 are hypersensitive to MNU induced thymic lymphoma and are partially protected by transgenic expression of human MGMT.
Microarray-based copy number analysis of neurofibromatosis type-1 (NF1)-associated malignant peripheral nerve sheath tumors reveals a role for Rho-GTPase pathway genes in NF1 tumorigenesis.
Microdissection and polymerase chain reaction amplification of genomic DNA from histological tissue sections.
MicroRNA and ovarian cancer.
MicroRNA regulation of K-Ras in pancreatic cancer and opportunities for therapeutic intervention.
MicroRNA Regulation of the Small Rho GTPase Regulators-Complexities and Opportunities in Targeting Cancer Metastasis.
MicroRNA-134-3p is a novel potential inhibitor of human ovarian cancer stem cells by targeting RAB27A.
MicroRNA-143 shows tumor suppressive effects through inhibition of oncogenic K-Ras in pituitary tumor.
MicroRNA-145 functions as a tumor suppressor by targeting matrix metalloproteinase 11 and Rab GTPase family 27a in triple-negative breast cancer.
microRNA-148a-3p inhibited the proliferation and epithelial-mesenchymal transition progression of non-small-cell lung cancer via modulating Ras/MAPK/Erk signaling.
MicroRNA-16 suppressed the invasion and migration of osteosarcoma by directly inhibiting RAB23.
MicroRNA-188-5p promotes apoptosis and inhibits cell proliferation of breast cancer cells via the MAPK signaling pathway by targeting Rap2c.
microRNA-195-Cdc42 axis acts as a prognostic factor of esophageal squamous cell carcinoma.
microRNA-214 functions as a tumor suppressor in human colon cancer via the suppression of ADP-ribosylation factor-like protein 2.
MicroRNA-29a functions as a potential tumor suppressor through directly targeting CDC42 in non-small cell lung cancer.
MicroRNA-382-5p aggravates breast cancer progression by regulating the RERG/Ras/ERK signaling axis.
MicroRNA-622 functions as a tumor suppressor by targeting K-Ras and enhancing the anticarcinogenic effect of resveratrol.
MicroRNA?195 suppresses cell proliferation, migration and invasion in epithelial ovarian carcinoma via inhibition of the CDC42/CCND1 pathway.
MicroRNA?342?3p suppresses proliferation and invasion of nasopharyngeal carcinoma cells by directly targeting Cdc42.
MicroRNAs targeting mutant K-ras by electrotransfer inhibit human colorectal adenocarcinoma cell growth in vitro and in vivo.
Microsatellite alterations and K-ras, TGFbetaRII, IGFRII and bax mutations in sporadic cancers of the gastrointestinal tract.
Microsatellite and EGFR, HER2 and K-RAS analyses in sclerosing hemangioma of the lung.
Microsatellite instability and K-ras mutations in gastric adenomas, with reference to associated gastric cancers.
Microsatellite instability and K-ras mutations in patients with ulcerative colitis.
Microsatellite instability and somatic mutations in endometrial carcinomas.
Microvessel density, cyclo-oxygenase 2 expression, K-ras mutation and p53 overexpression in colonic cancer.
Minireview: Role of genetic changes of faciogenital dysplasia protein 1 in human disease.
miR-1, regulated by LMP1, suppresses tumour growth and metastasis by targeting K-ras in nasopharyngeal carcinoma.
miR-107 functions as a tumor suppressor in human esophageal squamous cell carcinoma and targets Cdc42.
miR-133 is a key negative regulator of CDC42-PAK pathway in gastric cancer.
miR-137 targets Cdc42 expression, induces cell cycle G1 arrest and inhibits invasion in colorectal cancer cells.
miR-143 inhibits the metastasis of pancreatic cancer and an associated signaling pathway.
miR-144 suppresses cell proliferation and migration in colorectal cancer by targeting NRAS.
miR-145-5p Acts as a Novel Tumor Suppressor in Hepatocellular Carcinoma Through Targeting RAB18.
miR-181a shows tumor suppressive effect against oral squamous cell carcinoma cells by downregulating K-ras.
MiR-181d acts as a tumor suppressor in glioma by targeting K-ras and Bcl-2.
MiR-181d functions as a potential tumor suppressor in oral squamous cell carcinoma by targeting K-ras.
miR-185 targets RhoA and Cdc42 expression and inhibits the proliferation potential of human colorectal cells.
MiR-185-5p targets RAB35 gene to regulate tumor cell-derived exosomes-mediated proliferation, migration and invasion of non-small cell lung cancer cells.
miR-18a inhibits CDC42 and plays a tumour suppressor role in colorectal cancer cells.
MiR-199a Inhibits Tumor Growth and Attenuates Chemoresistance by Targeting K-RAS via AKT and ERK Signalings.
MiR-206 functions as a tumor suppressor and directly targets K-Ras in human oral squamous cell carcinoma [Retraction].
MiR-206 functions as a tumor suppressor and directly targets K-Ras in human oral squamous cell carcinoma.
miR-21 coordinates tumor growth and modulates KRIT1 levels.
miR-211 regulates the expression of RRM2 in tumoral metastasis and recurrence in colorectal cancer patients with a k-ras gene mutation.
miR-28-5p acts as a tumor suppressor in renal cell carcinoma for multiple antitumor effects by targeting RAP1B.
miR-29a/b/c function as invasion suppressors for gliomas by targeting CDC42 and predict the prognosis of patients.
miR-330 regulates the proliferation of colorectal cancer cells by targeting Cdc42.
miR-338-3p targets RAB23 and suppresses tumorigenicity of prostate cancer cells.
miR-384 suppressed renal cell carcinoma cell proliferation and migration through targeting RAB23.
miR-431 Promotes Metastasis of Pancreatic Neuroendocrine Tumors by Targeting DAB2 Interacting Protein, a Ras GTPase Activating Protein Tumor Suppressor.
MiR-455-5p acts as a novel tumor suppressor in gastric cancer by down-regulating RAB18.
MiR-501-3p functions as a tumor suppressor in non-small cell lung cancer by downregulating RAP1A.
miR-518b is down-regulated, and involved in cell proliferation and invasion by targeting Rap1b in esophageal squamous cell carcinoma.
miR-597-3p inhibits invasion and migration of thyroid carcinoma SW579 cell by targeting RAB23.
miR-769-5p is associated with prostate cancer recurrence and modulates proliferation and apoptosis of cancer cells.
miR?367?3p downregulates Rab23 expression and inhibits Hedgehog signaling resulting in the inhibition of the proliferation, migration, and invasion of prostate cancer cells.
miR?448 targets Rab2B and is pivotal in the suppression of pancreatic cancer.
miRNA-143 replacement therapy harnesses the proliferation and migration of colorectal cancer cells in vitro.
miRNA-34 prevents cancer initiation and progression in a therapeutically-resistant K-ras and p53-induced mouse model of lung adenocarcinoma.
miRNA-mRNA integrative analysis in primary myelofibrosis CD34+ cells: role of miR-155/JARID2 axis in abnormal megakaryopoiesis.
Mitofusin-2 over-expresses and leads to dysregulation of cell cycle and cell invasion in lung adenocarcinoma.
Mixtures of Uncaria and Tabebuia extracts are potentially chemopreventive in CBA/Ca mice: a long-term experiment.
MLL3 Induced by Luteolin Causes Apoptosis in Tamoxifen-Resistant Breast Cancer Cells through H3K4 Monomethylation and Suppression of the PI3K/AKT/mTOR Pathway.
Modeling human lung cancer in mice: similarities and shortcomings.
Modelling oncogenic Ras/Raf signalling in the mouse.
Modified mismatch polymerase chain reaction-restriction fragment length polymorphism detected mutations in codon 12 and 13 of exon 2 of K-
Modulation in vitro of H-ras oncogene expression by trans-splicing.
Modulation of ABCG2 surface expression by Rab5 and Rab21 to overcome multidrug resistance in cancer cells.
Modulation of apoptosis, tumorigenesity and metastatic potential with antisense H-ras oligodeoxynucleotides in a high metastatic tumor model of hepatoma: LCI-D20.
Modulation of azoxymethane-induced mutational activation of ras protooncogenes by chemopreventive agents in colon carcinogenesis.
Modulation of E-cadherin expression by K-Ras; involvement of DNA methyltransferase-3b.
Modulation of the Pol II CTD Phosphorylation Code by Rac1 and Cdc42 Small GTPases in Cultured Human Cancer Cells and Its Implication for Developing a Synthetic-Lethal Cancer Therapy.
Modulation of tumor induction and progression of oncogenic K-ras-positive tumors in the presence of TGF- b1 haploinsufficiency.
Molecular alteration of alpha-induced transformed Syrian hamster embryo cells.
Molecular alterations associated with improved survival in pancreatic cancer patients treated with radiation or chemotherapy.
Molecular alterations in spontaneous sputum of cancer-free heavy smokers: results from a large screening program.
Molecular analyses of liver tumors in c-myc transgenic mice and c-myc and TGF-alpha double transgenic mice.
Molecular analysis of oncogenes, ras family genes (N-ras, K-ras, H-ras), myc family genes (c-myc, N-myc) and mdm2 in natural killer cell neoplasms.
Molecular analysis of p53, MDM2 and H-ras genes in low-grade central osteosarcoma.
Molecular analysis of peritoneal fluid in ovarian cancer patients.
Molecular analysis to detect pancreatic ductal adenocarcinoma in high-risk groups.
Molecular and genetic events in schistosomiasis-associated human bladder cancer: role of oncogenes and tumor suppressor genes.
Molecular and genetic toxicology of 1,3-butadiene.
Molecular and immunohistochemical analysis of intraductal papillary neoplasms of the biliary tract.
Molecular and pathologic aspects of endometrial carcinogenesis.
Molecular and Pharmacological Characterization of the Interaction between Human Geranylgeranyltransferase Type I and Ras-Related Protein Rap1B.
Molecular approaches for colorectal cancer screening.
Molecular aspects of carcinogenesis in pancreatic cancer.
Molecular aspects of chemical carcinogenesis: the roles of oncogenes and tumour suppressor genes.
Molecular aspects of pancreatic cancer and future perspectives.
Molecular assessment of depth of myometrial invasion in stage I endometrial cancer: a model based on K-ras mutation analysis.
Molecular assessment of lymph nodes in patients with resected stage I non-small cell lung cancer: preliminary results of a prospective study.
Molecular Associations and Clinical Significance of RAPs in Hepatocellular Carcinoma.
Molecular Basis for Allosteric Inhibition of GTP-Bound H-Ras Protein by a Small-Molecule Compound Carrying a Naphthalene Ring.
Molecular basis of endometrial cancer.
Molecular beacon imaging of tumor marker gene expression in pancreatic cancer cells.
Molecular biology of colon polyps and colon cancer.
Molecular biology of pancreatic cancer: potential clinical implications.
Molecular biology of pancreatic cancer; oncogenes, tumour suppressor genes, growth factors, and their receptors from a clinical perspective.
Molecular biology studies on mesothelioma tumor samples: preliminary data on H-ras, p21, and SV40.
Molecular carcinogenesis of endometrial cancer.
Molecular changes in second primary lung and breast cancers after therapy for Hodgkin's disease.
Molecular characterisation of pancreatic ductal adenocarcinoma in patients under 40.
Molecular Characteristics of Fibrolamellar Hepatocellular Carcinoma.
Molecular characteristics of poorly differentiated adenocarcinoma and signet-ring-cell carcinoma of colorectum.
Molecular characteristics of recurrent triple-negative breast cancer.
Molecular characterization of adenocarcinoma of the cervix.
Molecular characterization of primary mediastinal B cell lymphoma.
Molecular cloning of Copenhagen rat Krev-1 and rap1B cDNAs and study of their association with mammary tumor resistance in the Copenhagen rat.
Molecular cloning of rat Krev-1 cDNA and analysis of the mRNA levels in normal and NMU-induced mammary carcinomas.
Molecular consequences of silencing mutant K-ras in pancreatic cancer cells: justification for K-ras-directed therapy.
Molecular detection of codon 12 K-RAS mutations in circulating DNA from serum of colorectal cancer patients.
Molecular detection of genetic alterations in the serum of colorectal cancer patients.
Molecular detection of neoplastic cells in lymph nodes of metastatic colorectal cancer patients predicts recurrence.
Molecular determinants of dysplasia in colorectal lesions.
Molecular Diagnosis of Response to Neoadjuvant Chemoradiation Therapy in Patients with Locally Advanced Rectal Cancer.
Molecular diagnostic testing as an adjunct to morphologic evaluation of pancreatic ductal system brushings: potential augmentation for diagnostic sensitivity.
Molecular docking studies of anti-cancerous candidates in Hippophae rhamnoides and Hippophae salicifolia.
Molecular epidemiology of pancreatic cancer.
Molecular epizootiology of genotoxic events in marine fish: linking contaminant exposure, DNA damage, and tissue-level alterations.
Molecular events underlying schistosomiasis-related bladder cancer.
Molecular evidence of field cancerization in a patient with 7 tumors of the aerodigestive tract.
Molecular evidence that most but not all carcinosarcomas of the uterus are combination tumors.
Molecular gate keepers succumb to gene aberrations in colorectal cancer in Kashmiri population, revealing a high incidence area.
Molecular genetic alterations in radiation-induced astrocytomas.
Molecular genetic analysis of appendiceal mucinous adenomas in identical twins, including one with pseudomyxoma peritonei.
Molecular genetic analysis of clear cell adenocarcinomas of the vagina and cervix associated and unassociated with diethylstilbestrol exposure in utero.
Molecular genetic analysis of placental site trophoblastic tumors and epithelioid trophoblastic tumors confirms their trophoblastic origin.
Molecular genetic changes associated with colorectal carcinogenesis are not prognostic for tumor regression following preoperative chemoradiation of rectal carcinoma.
Molecular genetic characterization of BRCA1- and BRCA2-linked hereditary ovarian cancers.
Molecular genetic evidence supporting the clonality and appendiceal origin of Pseudomyxoma peritonei in women.
Molecular genetic studies of sporadic pituitary tumors.
Molecular genetic tumor markers in the early diagnosis and screening of non-small-cell lung cancer.
Molecular genetics and endometrial cancer.
Molecular genetics and related developments in pancreatic cancer.
Molecular genetics of small bowel cancer.
Molecular lesions in colorectal cancer: impact on prognosis? Original data and review of the literature.
Molecular markers as intermediate end-points in chemoprevention of colon-cancer - modulation of ras activation by sulindac and phenylhexylisothiocyanate during colon carcinogenesis.
Molecular markers for diagnostic cytology of neoplasms in the head region of the pancreas: mutation of K-ras and overexpression of the p53 protein product.
Molecular markers in lung cancer: prognostic role and relationship to smoking.
Molecular markers of pancreatic cancer: development and clinical relevance.
Molecular mechanisms and biological plausibility underlying the malignant transformation of endometriosis: a critical analysis.
Molecular mechanisms of invasion and metastasis during mouse skin tumour progression.
Molecular mechanisms of platelet activation and aggregation induced by breast cancer cells.
Molecular Mechanisms of the Blockage of Glioblastoma Motility.
Molecular oncology in pancreatic cancer.
Molecular oncology--perspectives in lung cancer.
Molecular pathobiology of pancreatic adenocarcinoma.
Molecular pathogenesis of intraductal papillary mucinous neoplasms of the pancreas.
Molecular pathogenesis of pancreatic adenocarcinoma: Potential clinical implications.
Molecular pathogenesis of pancreatic cancer.
Molecular pathologic substaging in 244 stage I non-small-cell lung cancer patients: clinical implications.
Molecular pathology of endometrial hyperplasia and carcinoma.
Molecular pathology of hemangiopericytomas accompanied by severe hypoglycemia: oncogenes, tumor-suppressor genes and the insulin-like growth factor family.
Molecular pathology of ovarian carcinomas.
Molecular pathways of urothelial development and bladder tumorigenesis.
Molecular pathways: targeting p21-activated kinase 1 signaling in cancer--opportunities, challenges, and limitations.
Molecular pathways: targeting RAC-p21-activated serine-threonine kinase signaling in RAS-driven cancers.
Molecular pattern of ductal pancreatic cancer.
Molecular pharmacology and antitumor activity of PHT-427, a novel Akt/phosphatidylinositide-dependent protein kinase 1 pleckstrin homology domain inhibitor.
Molecular profiles of EGFR, K-ras, c-met, and FGFR in pulmonary pleomorphic carcinoma, a rare lung malignancy.
Molecular Profiling of Synchronous and Metachronous Cancers of the Pancreas Reveal Molecular Mimicry Between Samples from the Same Patient.
Molecular staging of colorectal cancer: K-ras mutation analysis of lymph nodes upstages Dukes B patients.
Molecular staging of non-small cell lung cancer according to K-ras genotypes.
Molecular subversion of Cdc42 signalling in cancer.
Molecular target-based therapy of pancreatic cancer.
Molecular targeted treatment and radiation therapy for rectal cancer.
Monitoring of gene expression by functional proteomics: response of human lung fibroblast cells to stimulation by endothelin-1.
Morelloflavone, a biflavonoid, inhibits tumor angiogenesis by targeting rho GTPases and extracellular signal-regulated kinase signaling pathways.
Morphologic change and elevation of cortisol secretion in cultured human normal adrenocortical cells caused by mutant p21K-ras protein.
Morphological and molecular characterization of an undifferentiated soft tissue sarcoma cell line and derivative clones.
Morphological and molecular heterogeneity in colorectal neoplasms with K-RAS mutation. A report of two cases.
Morphological and molecular heterogeneity within nonmicrosatellite instability-high colorectal cancer.
Mosaic analysis and tumor induction in zebrafish by microsatellite instability-mediated stochastic gene expression.
Motility-related proteins as markers for head and neck squamous cell cancer.
Mouse embryo fibroblasts transformed by activated ras or dominant-negative p53 express cross-reactive tumor rejection antigens.
Mouse mammary tumor virus/v-Ha-ras transgene-induced mammary tumors exhibit strain-specific allelic loss on mouse chromosome 4.
Mouse model for lung tumorigenesis through Cre/lox controlled sporadic activation of the K-Ras oncogene.
Mouse model for probing tumor suppressor activity of protein phosphatase 2A in diverse signaling pathways.
Mouse models of K-ras-initiated carcinogenesis.
Mouse tissues that undergo neoplastic progression after K-Ras activation are distinguished by nuclear translocation of phospho-Erk1/2 and robust tumor suppressor responses.
MSX2 in pancreatic tumor development and its clinical application for the diagnosis of pancreatic ductal adenocarcinoma.
Mucinous cystic carcinoma of the pancreas: a unique cell line and xenograft model of a preinvasive lesion.
Mucosal HPV E6/E7 Peptide Vaccination in Combination with Immune Checkpoint Modulation Induces Regression of HPV+ Oral Cancers.
Multicenter analysis of risk factors for anastomotic leakage after middle and low rectal cancer resection without diverting stoma: a retrospective study of 319 consecutive patients.
Multidisciplinary approach of colorectal liver metastases.
Multiple detection of genetic alterations in tumors and stool.
Multiple fluorescence-based PCR-SSCP analysis.
Multiple genetic alterations in hamster pancreatic ductal adenocarcinomas.
Multiple hyperplastic polyps in the stomach: evidence for clonality and neoplastic potential.
Multiple K-ras codon 12 mutations in cholangiocarcinomas demonstrated with a sensitive polymerase chain reaction technique.
Multiple pulmonary adenomas in the lung of transgenic mice overexpressing the RON receptor tyrosine kinase. Recepteur d'origine nantais.
Multiple stages in radiation carcinogenesis of rat skin.
Multiple synchronous primaries of the gastrointestinal tract: a molecular case report.
Multiplex PCR/LDR for detection of K-ras mutations in primary colon tumors.
Multiplicity of abnormal promoter methylation in lung adenocarcinomas from smokers and never smokers.
Multistage carcinogenesis in murine thymocytes: involvement of oncogenes, chromosomal imbalances and T cell growth factor receptor.
Multistep carcinogenesis in colorectal cancers.
Murine models of colorectal cancer: studying the role of oncogenic K-ras.
Mutagenesis in monkey cells of a vector containing a single d(GPG) cis-diamminedichloroplatinum(II) adduct placed on codon 13 of the human H-ras proto-oncogene.
Mutagenesis of the H-ras protooncogene and the p53 tumor suppressor gene.
Mutagenesis of the K-ras protooncogene in mouse lung tumors induced by N-ethyl-N-nitrosourea or N-nitrosodiethylamine.
Mutant DNA in plasma of lung cancer patients: potential for monitoring response to therapy.
Mutant K-Ras activation of the proapoptotic MST2 pathway is antagonized by wild-type K-Ras.
Mutant K-ras enhances apoptosis in embryonic stem cells in combination with DNA damage and is associated with increased levels of p19(ARF).
Mutant K-ras in apparently normal mucosa of colorectal cancer patients. Its potential as a biomarker of colorectal tumorigenesis.
Mutant K-ras promotes carcinogen-induced murine colorectal tumourigenesis, but does not alter tumour chromosome stability.
Mutant K-rasV12 increases COX-2, peroxides and DNA damage in lung cells.
Mutant ras oncogenes upregulate VEGF/VPF expression: implications for induction and inhibition of tumor angiogenesis.
Mutated D4-guanine diphosphate-dissociation inhibitor is found in human leukemic cells and promotes leukemic cell invasion.
Mutated K-ras gene analysis in a randomized trial of preoperative chemotherapy plus surgery versus surgery in stage IIIA non-small cell lung cancer.
Mutated ras p21 as a target for cancer therapy in mouse transitional cell carcinoma.
Mutated Ras peptides as vaccines in immunotherapy of cancer.
Mutation analysis of K-ras oncogenes in gastroenterologic cancers by the amplified created restriction sites method.
Mutation analysis of K-ras-2 in liver angiosarcoma and adjacent nonneoplastic liver tissue from patients occupationally exposed to vinyl chloride.
Mutation analysis of p53, K-ras, and BRAF genes in colorectal cancer progression.
Mutation and polymorphism in the EGFR-TK domain associated with lung cancer.
Mutation detection in K-ras, BRCA1, BRCA2, and p53 using PCR/LDR and a universal DNA microarray.
Mutation in the K-ras gene at codon 12 does not correlate with disease progression in colorectal carcinoma patients treated with 5-FU/folinic acid biomodulated chemotherapy.
Mutation of H-ras is infrequent in bladder cancer: confirmation by single-strand conformation polymorphism analysis, designed restriction fragment length polymorphisms, and direct sequencing.
Mutation of K-ras protooncogene in human ovarian epithelial tumors of borderline malignancy.
Mutation of K-ras protooncogene is associated with histological subtypes in human mucinous ovarian tumors.
Mutation of p53 and K-ras, and loss of heterozygosity of APC in intrahepatic cholangiocarcinoma.
Mutation of the nm23 gene, loss of heterozygosity at the nm23 locus and K-ras mutation in ovarian carcinoma: correlation with tumour progression and nm23 gene expression.
Mutation of the transforming growth factor-beta type II receptor gene in right-sided colorectal cancer: relationship to clinicopathological features and genetic alterations.
Mutation profile of the p53, fhit, p16INK4a/p19ARF and H-ras genes in Indian breast carcinomas.
Mutation Status of K-ras, p53 and Allelic Losses at 9p and 18q Are Not Prognostic Markers in Patients with Pancreatic Cancer.
Mutational activation of H-ras and K-ras genes is absent in N-nitroso-N-methylurea-induced liver tumors in rats.
Mutational activation of k-ras oncogene in human breast-tumors.
Mutational activation of the K-ras oncogene and the effect of chemotherapy in advanced adenocarcinoma of the lung: a prospective study.
Mutational activation of the K-ras oncogene. A possible pathogenetic factor in adenocarcinoma of the lung.
Mutational analysis of BRAF and K-ras in gastric cancers: absence of BRAF mutations in gastric cancers.
Mutational analysis of BRAF in gallbladder carcinomas in association with K-ras and p53 mutations and microsatellite instability.
Mutational analysis of EGFR and K-RAS genes in lung adenocarcinomas.
Mutational analysis of K-ras and Ras protein expression in larynx squamous cell carcinoma.
Mutational analysis of K-ras segregates ovarian serous carcinomas into two types: invasive MPSC (low-grade tumor) and conventional serous carcinoma (high-grade tumor).
Mutational analysis of Ras hotspots in patients with urothelial carcinoma of the bladder.
Mutational analysis of the BRAF gene in colorectal mucinous carcinoma in association with histological configuration.
Mutational analysis of the H-ras oncogene in spontaneous C57BL/6 x C3H/He mouse liver tumors and tumors induced with genotoxic and nongenotoxic hepatocarcinogens.
Mutational analysis of the HER2 gene in lung tumors from Caucasian patients: mutations are mainly present in adenocarcinomas with bronchioloalveolar features.
Mutational analysis of the p53 and K-ras genes and allelotype study of the Rb-1 gene for investigating the pathogenesis of combined hapatocellular-cholangiocellular carcinomas.
Mutational and nonmutational activation of p21ras in rat colonic azoxymethane-induced tumors: effects on mitogen-activated protein kinase, cyclooxygenase-2, and cyclin D1.
Mutational landscape of K-Ras substitutions at 12th position-a systematic molecular dynamics approach.
Mutational spectrum of K-ras oncogene among Indian patients with gallbladder cancer.
Mutational Targets in Colorectal Cancer Cells with Microsatellite Instability.
Mutationally activated K-ras 4A and 4B both mediate lung carcinogenesis.
Mutations and amplification of oncogenes in endometrial cancer.
Mutations associated with in vivo aflatoxin B1-induced carcinogenesis need not be present in the in vitro transformations by this toxin.
Mutations in an alternatively spliced exon of h-ras are not associated with loss of heterozygosity on chromosome 11p15.5 in ovarian tumorigenesis.
Mutations in APC, CTNNB1 and K-ras genes and expression of hMLH1 in sporadic colorectal carcinomas from the Netherlands Cohort Study.
Mutations in APC, Kirsten-ras, and p53--alternative genetic pathways to colorectal cancer.
Mutations in codons 12 and 13 of K-ras exon 2 in colorectal tumors of Saudi Arabian patients: frequency, clincopathological associations, and clinical outcomes.
Mutations in epidermal growth factor receptor and K-ras in Chinese patients with colorectal cancer.
Mutations in ras genes in experimental tumours of rodents.
Mutations in the c-Kit gene disrupt mitogen-activated protein kinase signaling during tumor development in adenoid cystic carcinoma of the salivary glands.
Mutations in the epidermal growth factor receptor gene are linked to smoking-independent, lung adenocarcinoma.
Mutations in the ras proto-oncogene: clues to etiology and molecular pathogenesis of mouse liver tumors.
Mutations of K-ras oncogene and absence of H-ras mutations in squamous cell carcinomas of the lung.
Mutations of K-ras oncogene in human adrenal tumours in Taiwan.
Mutations of p16Ink4/CDKN2 and p15Ink4B/MTS2 genes in biliary tract cancers.
Mutations of p53 and K-ras genes as prognostic factors for non-small cell lung cancer.
Mutations of the EGFR, K-ras, EML4-ALK, and BRAF genes in resected pathological stage I lung adenocarcinoma.
Mutations of the epidermal growth factor receptor gene in atypical adenomatous hyperplasia and bronchioloalveolar carcinoma of the lung.
Mutations of the K-ras and p53 genes in gastric adenocarcinomas from a high-incidence region around Florence, Italy.
Mutations of the p53 gene and p53 protein overexpression are associated with sarcomatoid transformation in renal cell carcinomas.
Mutations, expression and genomic instability of the H-ras proto-oncogene in squamous cell carcinomas of the head and neck.
Mutually exclusive mutations of the Pten and ras pathways in skin tumor progression.
MutYH (MYH) and colorectal cancer.
MYC is a metastasis gene for non-small-cell lung cancer.
MYC-nick promotes cell migration by inducing fascin expression and Cdc42 activation.
Myosin-interacting guanine exchange factor (MyoGEF) regulates the invasion activity of MDA-MB-231 breast cancer cells through activation of RhoA and RhoC.
N-nitrosocimetidine as an initiator of murine skin tumors with associated H-ras oncogene activation.
NAD(P)H:quinone oxidoreductase-dependent risk for colorectal cancer and its association with the presence of K-ras mutations in tumors.
Nanobody-Based Quantification of GTP-Bound RHO Conformation Reveals RHOA and RHOC Activation Independent from Their Total Expression in Breast Cancer.
Nanomechanical Characteristics of Cervical Cancer and Cervical Intraepithelial Neoplasia Revealed by Atomic Force Microscopy.
Nanoparticle delivery of an AKT/PDK1 inhibitor improves the therapeutic effect in pancreatic cancer.
Natural history of colorectal nonpolypoid adenomas: a prospective colonoscopic study and relation with cell kinetics and K-ras mutations.
Natural killer cell regulation of implantation and early lung growth of H-ras-transformed 10T1/2 fibroblasts in mice.
NDRG1 regulates Filopodia-induced Colorectal Cancer invasiveness via modulating CDC42 activity.
Negative Control of Cell Migration by Rac1b in Highly Metastatic Pancreatic Cancer Cells Is Mediated by Sequential Induction of Nonactivated Smad3 and Biglycan.
Negative regulation of CDC42 expression and cell cycle progression by miR-29a in breast cancer.
Negative regulation of p53 by Ras superfamily protein RBEL1A.
Neoplastic reprogramming of patient-derived adipose stem cells by prostate cancer cell-associated exosomes.
Neoplastic reversion accomplished by high efficiency adenoviral-mediated delivery of an anti-ras ribozyme.
Neoplastic transformation of human keratinocytes by polybrene-induced DNA-mediated transfer of an activated oncogene.
Neoplastic transformation of human osteoblast cells to the tumorigenic phenotype by heavy metal-tungsten alloy particles: induction of genotoxic effects.
Neoplastic transformation of rat colon epithelial cells by expression of activated human K-ras.
Neratinib inhibits Hippo/YAP signaling, reduces mutant K-RAS expression, and kills pancreatic and blood cancer cells.
Nestin predicts a favorable prognosis in early ampullary adenocarcinoma and functions as a promoter of metastasis in advanced cancer.
Neurofibromatosis type 1: Fundamental insights into cell signalling and cancer.
Neurofibromatosis-like phenotype in Drosophila caused by lack of glucosylceramide extension.
Neurofibromin 1 Impairs Natural Killer T-Cell-Dependent Antitumor Immunity against a T-Cell Lymphoma.
Neurofibromin can inhibit Ras-dependent growth by a mechanism independent of its GTPase-accelerating function.
Neurofibromin is required for barrel formation in the mouse somatosensory cortex.
Neutron radiation can activate K-ras via a point mutation in codon 146 and induces a different spectrum of ras mutations than does gamma radiation.
Neutrophil elastase-mediated degradation of IRS-1 accelerates lung tumor growth.
New insights into the interplay between autophagy, gut microbiota and inflammatory responses in IBD.
New molecular approaches to lung cancer: biological and clinical implications of P53, P16 and K-RAS studies.
New Variations in the Promoter Regions of Human DOCK4 and RAP1A Genes, and Coding Regions of RAP1A in Sporadic Breast Tumors.
NGAL decreases E-cadherin-mediated cell-cell adhesion and increases cell motility and invasion through Rac1 in colon carcinoma cells.
Nicotine does not enhance tumorigenesis in mutant K-ras-driven mouse models of lung cancer.
Nicotine promotes mammary tumor migration via a signaling cascade involving protein kinase C and CDC42.
NIH3T3 transfectant containing human K-ras oncogene shows enhanced metastatic activity after in vivo tumor growth or co-culture with fibroblasts.
Nitrosamine-induced cancer: selective repair and conformational differences between O6-methylguanine residues in different positions in and around codon 12 of rat H-ras.
NKX6.3 Is a Transcription Factor for Wnt/?-catenin and Rho-GTPase Signaling-Related Genes to Suppress Gastric Cancer Progression.
Nm23-H1 modulates the activity of the guanine exchange factor Dbl-1.
NMR 1H,13C, 15N backbone and 13C side chain resonance assignment of the G12C mutant of human K-Ras bound to GDP.
NMR 1H,13C, 15N resonance assignment of the G12C mutant of human K-Ras bound to GppNHp.
NMR-based functional profiling of RASopathies and oncogenic RAS mutations.
No back seat for a progression event-K-RAS as a therapeutic target in CRC.
No evidence for point mutations in codons 12, 13, and 61 of the ras gene in a high-incidence area for esophageal and gastric cancers.
No major difference in K-ras and p53 abnormalities in sporadic and hereditary nonpolyposis colorectal adenomas.
No-touch isolation technique reduces intraoperative shedding of tumor cells into the portal vein during resection of colorectal cancer.
Non-radioactive detection of K-ras mutations by nested allele specific PCR and oligonucleotide hybridization.
Non-small cell lung cancer. Part I: Biology, diagnosis, and staging.
Non-small cell lung cancer. Part II: Treatment.
Non-Small-Cell Lung Cancer Signaling Pathways, Metabolism, and PD-1/PD-L1 Antibodies.
Non-Substrate Based, Small Molecule Inhibitors of the Human Isoprenylcysteine Carboxyl Methyltransferase.
Noncorrelative c-myc and ras oncogene expression in squamous cell carcinoma cells with tumorigenic potential.
Nonfunctioning islet cell carcinoma of the pancreas with high serum CEA & CA19-9, K-ras codon 12 mutation, and microsatellite instability.
Noninvasive image texture analysis differentiates K-ras mutation from pan-wildtype NSCLC and is prognostic.
Not infrequent K-ras mutations in depressed-type early colorectal carcinomas larger than 10 mm.
Notch1 destabilizes the adherens junction complex through upregulation of the Snail family of E-cadherin repressors in non-small cell lung cancer.
Novel anti-carcinogenic activity of an organosulfide from garlic: inhibition of H-RAS oncogene transformed tumor growth in vivo by diallyl disulfide is associated with inhibition of p21H-ras processing.
Novel involvement of RhebL1 in sphingosylphosphorylcholine-induced keratin phosphorylation and reorganization: Binding to and activation of AKT1.
Novel molecular profiles of endometrial cancer-new light through old windows.
Novel Regulation of Integrin Trafficking by Rab11-FIP5 in Aggressive Prostate Cancer.
Novel Suppressive Effects of Ketotifen on Migration and Invasion of MDA-MB-231 and HT-1080 Cancer Cells.
Novel synthetic oleanane triterpenoid AMR-MeOAc inhibits K-Ras through ERK, Akt and survivin in pancreatic cancer cells.
Novel targeting approaches and signaling pathways of colorectal cancer: An insight.
Novel ternary vanadium-betaine-peroxido species suppresses H-ras and matrix metalloproteinase-2 expression by increasing reactive oxygen species-mediated apoptosis in cancer cells.
Novel therapies for pancreatic cancer.
Novel transplatinum(II) complexes with [N2O2] donor sets. Cellular pharmacology and apoptosis induction in Pam 212-ras cells.
NRAS mutation causes a human autoimmune lymphoproliferative syndrome.
Nrf2 Activation Sensitizes K-Ras Mutant Pancreatic Cancer Cells to Glutaminase Inhibition.
NTP Toxicology and Carcinogenesis Studies of Oxazepam (CAS No. 604-75-1) in Swiss-Webster and B6C3F1 Mice (Feed Studies).
Nuclear factor-kappaB (NF-kappaB) is frequently expressed in lung cancer and preneoplastic lesions.
Nuclear-targeted deleted in liver cancer 1 (DLC1) is less efficient in exerting its tumor suppressive activity both in vitro and in vivo.
Nucleotide-Specific Autoinhibition of Full-Length K-Ras4B Identified by Extensive Conformational Sampling.
Nullifying the CDKN2A/B Locus Promotes Mutant K-ras Lung Tumorigenesis.
O(6)-methylguanine methyltransferase in colorectal cancers: detection of mutations, loss of expression, and weak association with G:C>A:T transitions.
O(6)-Methylguanine-DNA methyltransferase promoter hypermethylation shifts the p53 mutational spectrum in non-small cell lung cancer.
O-GlcNAcylation on Rab3A attenuates its effects on mitochondrial oxidative phosphorylation and metastasis in hepatocellular carcinoma.
O6-methylguanine-DNA methyltransferase promoter hypermethylation in colorectal carcinogenesis.
Occupational exposure to dyes, metals, polycyclic aromatic hydrocarbons and other agents and K-ras activation in human exocrine pancreatic cancer.
Occupational exposure to organic solvents and K-ras mutations in exocrine pancreatic cancer.
Occurrence of H-ras codon 61 CAA to AAA mutation during mouse liver tumor progression.
Occurrence of mutations in the epidermal growth factor receptor gene in X-ray-induced rat lung tumors.
Occurrence of ras mutations in human lung cancer. Minireview.
ODAM inhibits RhoA-dependent invasion in breast cancer.
Oligomycins as inhibitors of K-Ras plasma membrane localisation.
Oligonucleotide treatment of ras-induced tumors in nude mice.
On the oncodevelopmental role of human imprinted genes.
Oncogene alterations in primary human colon tumors.
Oncogene alterations in rat colon tumors induced by N-methyl-N-nitrosourea.
Oncogene amplification in squamous cell carcinoma of the oral cavity.
Oncogene and growth factor expression in MEN 2 and related tumors.
Oncogene involvement in tumor regression: H-ras activation in the rabbit keratoacanthoma model.
Oncogene mediated repression of glucocorticoid hormone response elements and glucocorticoid receptor levels.
Oncogene pathway activation in mammary tumors dictates FDG-PET uptake.
Oncogene profile of papillary thyroid carcinoma.
Oncogene Ras/Phosphatidylinositol 3-kinase (PI3K) signaling targets histone H3 acetylation at lysine K56.
Oncogene-dependent survival of highly transformed cancer cells under conditions of extreme centrifugal force - implications for studies on extracellular vesicles.
Oncogenes and cancer: the p21 ras genes.
Oncogenes and metastatic progression.
Oncogenes and radiation carcinogenesis.
Oncogenes in head and neck cancer.
Oncogenesis and the Clinical Significance of K-ras in Pancreatic Adenocarcinoma.
Oncogenesis driven by the Ras/Raf pathway requires the SUMO E2 ligase Ubc9.
Oncogenesis in ovarian cancer.
Oncogenic activation of NF-kappaB.
Oncogenic alterations in primary human lung-tumors (review).
Oncogenic and wild-type Ras play divergent roles in the regulation of mitogen-activated protein kinase signaling.
Oncogenic Ect2 signaling regulates rRNA synthesis in NSCLC.
Oncogenic effects of RAB27B through exosome independent function in renal cell carcinoma including sunitinib-resistant.
Oncogenic events regulate tissue factor expression in colorectal cancer cells: implications for tumor progression and angiogenesis.
Oncogenic G12D mutation alters local conformations and dynamics of K-Ras.
Oncogenic H-ras stimulates tumor angiogenesis by two distinct pathways.
Oncogenic K-ras activates p38 to maintain colorectal cancer cell proliferation during MEK inhibition.
Oncogenic K-Ras Binds to an Anionic Membrane in Two Distinct Orientations: A Molecular Dynamics Analysis.
Oncogenic K-Ras decouples glucose and glutamine metabolism to support cancer cell growth.
Oncogenic K-Ras down-regulates Rac1 and RhoA activity and enhances migration and invasion of pancreatic carcinoma cells through activation of p38.
Oncogenic K-ras Induces Mitochondrial OPA3 Expression to Promote Energy Metabolism in Pancreatic Cancer Cells.
Oncogenic K-Ras segregates at spatially distinct plasma membrane signaling platforms according to its phosphorylation status.
Oncogenic K-Ras signals through epidermal growth factor receptor and wild-type H-Ras to promote radiation survival in pancreatic and colorectal carcinoma cells.
Oncogenic K-Ras Turns Death Receptors Into Metastasis-Promoting Receptors in Human and Mouse Colorectal Cancer Cells.
Oncogenic levels of mitogen-activated protein kinase (MAPK) signaling of the dinucleotide KRAS2 mutations G12F and GG12-13VC.
Oncogenic pathway of sporadic colorectal cancer with novel germline missense mutations in the hMSH2 gene.
Oncogenic Pathways and Loss of the Rab11 GTPase Synergize To Alter Metabolism in Drosophila.
Oncogenic Ras Isoforms Signaling Specificity at the Membrane.
Oncogenic Ras mutant causes the hyperactivation of NF-?B via acceleration of its transcriptional activation.
Oncogenic Ras promotes butyrate-induced apoptosis through inhibition of gelsolin expression.
Oncogenic Ras triggers hyperproliferation and impairs polarized colonic morphogenesis by autocrine ErbB3 signaling.
Oncogenic ras-driven cancer cell vesiculation leads to emission of double-stranded DNA capable of interacting with target cells.
Oncogenic RAS-induced downregulation of ATG12 is required for survival of malignant intestinal epithelial cells.
Oncogenic signaling is dominant to cell of origin and dictates astrocytic or oligodendroglial tumor development from oligodendrocyte precursor cells.
Oncogenic Smad3 signaling induced by chronic inflammation is an early event in ulcerative colitis-associated carcinogenesis.
Oncogenicity of DNA in vivo: tumor induction with expression plasmids for activated H-ras and c-myc.
Oncolytic viral therapy for human pancreatic cancer cells by reovirus.
Oncomutations as biomarkers of cancer risk.
Oncosuppressor methylation: A possible key role in colon metastatic progression.
Oncosuppressor methylation: a possible key role in colon metastatic progression.
Opposing prognostic roles of nuclear and cytoplasmic RACGAP1 expression in colorectal cancer patients.
Optimal preservation of p21 ras immunoreactivity and morphology in paraffin-embedded tissue.
Optimization of a nonradioactive method for consistent and sensitive determination of activated K-ras protein.
Oral benzo[a]pyrene-induced cancer: two distinct types in different target organs depend on the mouse Cyp1 genotype.
Oral mucosal carcinogenesis in SENCAR mice.
Organochlorine exposure and colorectal cancer risk.
Origin of giant cells in osteoclast-like giant cell tumors of the pancreas.
Ornithine decarboxylase gene expression is aberrantly regulated via the cAMP signal transduction pathway in malignant H-ras transformed cell lines.
Orthotopic models of human pancreatic cancer.
Orthotopic transplantation model of human gastrointestinal cancer and detection of micrometastases.
Orthotopic transplantation models of pancreatic adenocarcinoma derived from cell lines and primary tumors and displaying varying metastatic activity.
Orthotopic xenografts of human pancreatic carcinomas acquire genetic aberrations during dissemination in nude mice.
Osteoclast-like giant cell tumor in mucinous cystadenocarcinoma of the pancreas: an immunohistochemical and molecular analysis.
Osteoclast-like giant cell tumor of the pancreas with metastases to gallbladder and lymph nodes. A case report.
Osteopontin, a transformation-associated cell adhesion phosphoprotein, is induced by 12-O-tetradecanoylphorbol 13-acetate in mouse epidermis.
Outcome of pancreatic cancer patients based on genetic lymph node staging.
Ovarian adenocarcinomas in the laying hen and women share similar alterations in p53, ras, and HER-2/neu.
Ovarian cancer: Stat3, RhoA and IGF-IR as therapeutic targets.
Ovarian clear cell carcinomas: RHO GTPases may contribute to explain their singular biologic behavior.
Ovarian mucinous tumor with malignant mural nodules: dedifferentiation or collision?
Ovarian Tumor Microenvironment Signaling: Convergence on the Rac1 GTPase.
Over-expression of Rap2a inhibits glioma migration and invasion by down-regulating p-AKT.
Overexpressed galectin-3 in pancreatic cancer induces cell proliferation and invasion by binding ras and activating ras signaling.
Overexpressed let-7a inhibits glioma cell malignancy by directly targeting K-ras, independently of PTEN.
Overexpression and biological function of IQGAP3 in human pancreatic cancer.
Overexpression of ARHGAP30 suppresses growth of cervical cancer cells by downregulating ribosome biogenesis.
Overexpression of Bcl-2 and mutations in p53 and K-ras in resected human non-small cell lung cancers.
Overexpression of human H-ras transgene is responsible for tumors induced by chemical carcinogens in mice.
Overexpression of P21-activated kinase 4 is associated with poor prognosis in non-small cell lung cancer and promotes migration and invasion.
Overexpression of p53 protein in adenocarcinoma of the pancreas.
Overexpression of Rab1B and MMP9 predicts poor survival and good response to chemotherapy in patients with colorectal cancer.
Overexpression of Rab27B is correlated with distant metastasis and poor prognosis in ovarian cancer.
Overexpression of Rab40b Promotes Hepatocellular Carcinoma Cell Proliferation and Metastasis via PI3K/AKT Signaling Pathway.
Overexpression of Rac GTPase Activating Protein 1 Contributes to Proliferation of Cancer Cells by Reducing Hippo Signaling to Promote Cytokinesis.
Overexpression of rho effector rhotekin confers increased survival in gastric adenocarcinoma.
Overexpression of RhoA, Rac1, and Cdc42 GTPases is associated with progression in testicular cancer.
Overexpression of RhoV Promotes the Progression and EGFR-TKI Resistance of Lung Adenocarcinoma.
Overexpression of ROCK in human breast cancer cells: evidence that ROCK activity mediates intracellular membrane traffic of lysosomes.
Overexpression of SAP-1, a transmembrane-type protein tyrosine phosphatase, in human colorectal cancers.
Overexpression of the p53 tumor suppressor gene product in primary lung adenocarcinomas is associated with cigarette smoking.
Overexpression of the rhoC gene correlates with progression of ductal adenocarcinoma of the pancreas.
Overexpression of vascular endothelial growth factor isoforms drives oxygenation and growth but not progression to glioblastoma multiforme in a human model of gliomagenesis.
Overview of Current Immunotherapies Targeting Mutated KRAS Cancers.
Overview of genetic and molecular events in the pathogenesis of lung cancer.
p120-catenin is transcriptionally downregulated by FOXC2 in non-small cell lung cancer cells.
P14 methylation in human colon cancer is associated with microsatellite instability and wild-type p53.
p14ARF promoter hypermethylation in plasma DNA as an indicator of disease recurrence in bladder cancer patients.
p16 and K-ras gene mutations in the intraductal precursors of human pancreatic adenocarcinoma.
p16(INK4A) Hypermethylation detected by fluorescent methylation-specific PCR in plasmas from non-small cell lung cancer.
P190B RhoGAP Regulates Chromosome Segregation in Cancer Cells.
p19Arf-p53 tumor suppressor pathway regulates cell motility by suppression of phosphoinositide 3-kinase and Rac1 GTPase activities.
P2X7 mRNA expression in non-small cell lung cancer: MicroRNA regulation and prognostic value.
p38 kinase is a key signaling molecule for H-Ras-induced cell motility and invasive phenotype in human breast epithelial cells.
p53 Activation by Blocking Snail : A Novel Pharmacological Strategy for Cancer.
p53 and H-ras mutations and microsatellite instability in renal pelvic carcinomas of NON / Shi mice treated with N-butyl-N-(4-hydroxybutyl)-nitrosamine: different genetic alteration from urinary bladder carcinoma.
p53 and K-ras gene mutations correlate with tumor aggressiveness but are not of routine prognostic value in colorectal cancer.
p53 and K-ras gene mutations in carcinoma of the rectum among Finnish women.
p53 and K-ras in radon-associated lung adenocarcinoma.
p53 and K-ras mutational genotyping in pulmonary carcinosarcoma, spindle cell carcinoma, and pulmonary blastoma: implications for histogenesis.
P53 and K-ras mutations are frequent events in microscopically negative surgical margins from patients with nonsmall cell lung carcinoma.
p53 and K-ras mutations in lung tissues and sputum samples of individuals exposed to smoky coal emissions in Xuan Wei County, China.
p53 and K-ras status in duodenal adenomas in familial adenomatous polyposis.
p53 and ras gene expression in human esophageal cancer and Barrett's epithelium: a prospective study.
p53 expression and K-ras mutation in colorectal adenomas.
p53 gene mutation and p53 protein overexpression in a patient with simultaneous double cancer of the gallbladder and bile duct associated with pancreaticobiliary maljunction.
P53 in RhoA regulation.
P53 mutation but not p16/MTS1 mutation occurs in intraductal papillary mucinous tumors of the pancreas.
p53 mutations and overexpression affect prognosis of ovarian endometrioid cancer but not clear cell cancer.
P53 mutations in colorectal cancer from northern Iran: Relationships with site of tumor origin, microsatellite instability and K-ras mutations.
p53 mutations in head and neck squamous cell carcinomas from Sudanese snuff (toombak) users.
p53 mutations in lung tumors: relationship to putative susceptibility markers for cancer.
p53 mutations in phenacetin-associated human urothelial carcinomas.
p53 mutations, ras mutations, and p53-heat shock 70 protein complexes in human lung carcinoma cell lines.
p53 Overexpression and K-ras Codon 12 Mutations in Submucosal Invasive Colorectal Cancer.
p53 overexpression and K-ras codon 12 mutations in submucosal invasive depressed-type colorectal cancer.
p53 overexpression and K-ras gene mutations in primary sclerosing cholangitis-associated biliary tract cancer.
p53 protein overexpression and K-ras codon 12 mutation in pancreatic ductal carcinoma: correlation with histologic factors.
p53 tumor suppressor protein and H-RAS oncogene in maxillofacial tumors: immunohistochemical and genetic investigation, induction chemotherapy response and prognosis evaluation.
p53, erbB-2 and K-ras gene alterations are rare in spontaneous and plutonium-239-induced canine lung neoplasia.
p53, K-ras, c-kit and beta-catenin gene mutations in sinonasal NK/T-cell lymphoma in Korea and Japan.
P53, N- and K-Ras, and beta-catenin gene mutations and prognostic factors in nasal NK/T-cell lymphoma from Hokkaido, Japan.
P68 RNA helicase (DDX5) alters activity of cis- and trans-acting factors of the alternative splicing of H-Ras.
p73 Isoforms affect VEGF, VEGF165b and PEDF expression in human colorectal tumors: VEGF165b downregulation as a marker of poor prognosis.
P76RBE silencing inhibits ovarian cancer cell proliferation, migration, and invasion via suppressing the integrin ?1/NF-?B pathway.
Paired-like homeoprotein ESXR1 acts as a sequence-specific transcriptional repressor of the human K-ras gene.
Palladin promotes invasion of pancreatic cancer cells by enhancing invadopodia formation in cancer-associated fibroblasts.
Pamidronate resistance and associated low ras levels in breast cancer cells: a role for combinatorial therapy.
Pancreatic adenocarcinomas with DNA replication errors (RER+) are associated with wild-type K-ras and characteristic histopathology. Poor differentiation, a syncytial growth pattern, and pushing borders suggest RER+.
Pancreatic cancer cell radiation survival and prenyltransferase inhibition: the role of K-Ras.
Pancreatic cancer heterogeneity and response to Mek inhibition.
Pancreatic cancer: a plea for good and comprehensive morphological studies.
Pancreatic cancer: epidemiology, genetics, and approaches to screening.
Pancreatic cancer: the potential clinical relevance of alterations in growth factors and their receptors.
Pancreatic carcinoma accompanied by pseudocyst: report of two cases.
Pancreatic cyst fluid analysis--a review.
Pancreatic cyst fluid DNA analysis in evaluating pancreatic cysts: a report of the PANDA study.
Pancreatic Ductal Adenocarcinoma and Transcription Factors: Role of c-Myc.
Pancreatic mucinous cystic neoplasms with sarcomatous stroma: molecular evidence for monoclonal origin with subsequent divergence of the epithelial and sarcomatous components.
Pancreatic tumor cells with mutant K-ras suppress ERK activity by MEK-dependent induction of MAP kinase phosphatase-2.
Pancreatitis-induced inflammation contributes to pancreatic cancer by inhibiting oncogene-induced senescence.
Partial growth suppression of human prostate cancer cells by the Krev-1 suppressor gene.
Partial response after treatment with Conversion chemotherapy: A case report of a patient with colon cancer and unresectable hepatic metastases.
Participation of small GTPases Rac1 and Cdc42Hs in myoblast transformation.
Past medical conditions and K-ras mutations in pancreatic ductal adenocarcinoma: a hypothesis-generating study.
Pathogenesis of adenocarcinoma in Peutz-Jeghers syndrome.
Pathogenesis of ovarian cancers.
Pathogenetic mechanisms and treatment options for ophthalmic pterygium: Trends and perspectives (Review).
Pathologic and molecular features of screening low-dose computed tomography (LDCT)-detected lung cancer: a baseline and 2-year repeat study.
Pathological functions of the small GTPase Arf6 in cancer progression: Tumor angiogenesis and metastasis.
Pathway activation strength is a novel independent prognostic biomarker for cetuximab sensitivity in colorectal cancer patients.
Pattern of growth factor, proto-oncogene and carcinoembryonic antigen gene expression in human colorectal carcinoma cell lines.
Patterns of genetic alterations in pancreatic cancer: a pooled analysis.
Patterns of K-ras mutation in colorectal carcinomas from Iran and Italy (a Gruppo Oncologico dell'Italia Meridionale study): influence of microsatellite instability status and country of origin.
Paving the Rho in cancer metastasis: Rho GTPases and beyond.
PCR bias toward the wild-type k-ras and p53 sequences: implications for PCR detection of mutations and cancer diagnosis.
PCR-SSCP analysis of human adrenocortical adenomas: absence of K-ras gene mutations.
PEA-15 potentiates H-Ras-mediated epithelial cell transformation through phospholipase D.
Peptide modulators of Rac1/Tiam1 protein-protein interaction: An alternative approach for cardiovascular diseases.
Peptide nucleic acid clamp PCR: a novel K-ras mutation detection assay for colorectal cancer micrometastases in lymph nodes.
Peptide-specific activation of cytolytic CD4+ T lymphocytes against tumor cells bearing mutated epitopes of K-ras p21.
Peroxiredoxin I is important for cancer-cell survival in Ras-induced hepatic tumorigenesis.
Persistence of K-ras mutations in plasma after colorectal tumor resection.
Pharmacodynamics of DT-IgG, a dual-targeting antibody against VEGF-EGFR, in tumor xenografted mice.
Pharmacokinetics of Rac inhibitor EHop-016 in mice by ultra-performance liquid chromatography tandem mass spectrometry.
Pharmacological Rac1 inhibitors with selective apoptotic activity in human acute leukemic cell lines.
Phase I and pharmacokinetic study of the farnesyltransferase inhibitor R115777 in combination with irinotecan in patients with advanced cancer.
Phase I clinical and pharmacologic study of chronic oral administration of the farnesyl protein transferase inhibitor R115777 in advanced cancer.
Phase I clinical trial of the farnesyltransferase inhibitor BMS-214662 given as a 1-hour intravenous infusion in patients with advanced solid tumors.
Phase I combination of sorafenib and erlotinib therapy in solid tumors: safety, pharmacokinetic, and pharmacodynamic evaluation from an expansion cohort.
Phase I Trial: Cirmtuzumab Inhibits ROR1 Signaling and Stemness Signatures in Patients with Chronic Lymphocytic Leukemia.
Phenotype of bone metastases of non-small cell lung cancer: epidermal growth factor receptor expression and K-RAS mutational status.
Phenotypic and molecular characteristics of hyperplastic polyposis.
Phenotypic characterisation of breast cancer: the role of CDC42.
Phenotypic classification of gastric signet ring cell carcinoma and its relationship with K-ras mutation.
Phenotypic reversion induced by anthracyclines in ras oncogene-expressed cells; structure-activity relationships.
Phenotypic Screening Identifies Protein Synthesis Inhibitors as H-Ras-Nanocluster-Increasing Tumor Growth Inducers.
Phorbol ester tumour promoter mediated altered expression and regulation of matrix metalloproteinase-2 in a H-ras transformed cell line capable of benign tumour formation.
Phosphodiesterase 5 inhibitors enhance chemotherapy killing in gastrointestinal/genitourinary cancer cells.
Phosphoinositide 3-Kinase Signaling Pathway in Pancreatic Ductal Adenocarcinoma Progression, Pathogenesis, and Therapeutics.
Phospholipase D provides a survival signal in human cancer cells with activated H-Ras or K-Ras.
Phosphorylation of Rab37 by protein kinase C alpha inhibits the exocytosis function and metastasis suppression activity of Rab37.
Photobiology and genetics of malignant melanoma.
Physical Mechanisms of Cancer in the Transition to Metastasis.
Phytohemagglutinin-L (PHA-L) lectin surface binding of N-linked beta 1-6 carbohydrate and its relationship to activated mutant ras in human pancreatic cancer cell lines.
PI3-kinase ? promotes Rap1a-mediated activation of myeloid cell integrin ?4?1, leading to tumor inflammation and growth.
PI3K, Rac1 and pPAK1 are overexpressed in extramammary Paget's disease.
PIK3CA mutations in the kinase domain (exon 20) of uterine endometrial adenocarcinomas are associated with adverse prognostic parameters.
PKC Regulates a Farnesyl-Electrostatic Switch on K-Ras that Promotes its Association with Bcl-Xl on Mitochondria and Induces Apoptosis.
PKC? regulates integrin ?V?3 expression and transformed growth of K-ras dependent lung cancer cells.
Plasma DNA K-ras mutations in patients with gastrointestinal malignancies.
Pleiotropic functions of Rho GTPase signaling: a Trojan horse or Achilles' heel for breast cancer treatment?
Podoplanin promotes the invasion of oral squamous cell carcinoma in coordination with MT1-MMP and Rho GTPases.
Point mutation analysis of ras genes in spontaneous and chemically induced C57Bl/10J mouse liver tumours.
Point mutation of K-ras gene codon 12 in biliary tract tumors.
Point mutation of K-ras gene in cisplatin-induced lung tumours in A/J mice.
Point mutations of K-ras and H-ras genes in forestomach neoplasms from control B6C3F1 mice and following exposure to 1,3-butadiene, isoprene or chloroprene for up to 2-years.
Point mutations of ras and Gs alpha subunit genes in thyroid tumors.
Point mutations of ras oncogenes are an early event in thyroid tumorigenesis.
Polarization of Drosophila neuroblasts during asymmetric division.
Polyamine biosynthesis in relation to K-ras and p-53 mutations in colorectal carcinoma.
Polyisoprenylated Cysteinyl Amide Inhibitors: A Novel Approach to Controlling Cancers with Hyperactive Growth Signaling.
Polylysine and CVIM sequences of K-RasB dictate specificity of prenylation and confer resistance to benzodiazepine peptidomimetic in vitro.
Polymer Nanovesicle-Mediated Delivery of MLN8237 Preferentially Inhibits Aurora Kinase A To Target RalA and Anchorage-Independent Growth in Breast Cancer Cells.
Polymerase chain reaction-based K-ras mutation detection of pancreatic adenocarcinoma in routine cytology smears.
Polymerase chain reaction/sequencing analysis of ras mutations in paraffin-embedded tissues as compared with 3T3 transfection and polymerase chain reaction/sequencing of frozen tumor deoxyribonucleic acids.
Polymorphic variants of H-RAS protooncogene and their possible role in bladder cancer etiology.
Polymorphisms in cyclooxygenase-2 and epidermal growth factor receptor are associated with progression-free survival independent of K-ras in metastatic colorectal cancer patients treated with single-agent cetuximab.
Polysialylated NCAM represses E-cadherin-mediated cell-cell adhesion in pancreatic tumor cells.
Portal Venous Blood Circulation Supports Immunosuppressive Environment and Pancreatic Cancer Circulating Tumor Cell Activation.
Positive immunohistochemical staining of p53 and cyclin D in advanced mouse skin tumors, but not in precancerous lesions produced by benzo[a]pyrene.
Possible association of active gastritis, featuring accelerated cell turnover and p53 overexpression, with cancer development at anastomoses after gastrojejunostomy. Comparison with gastroduodenostomy.
Possible carcinogenic effects of X-rays in a transgenerational study with CBA mice.
Possible role of activated ras genes in human esophageal carcinogenesis.
Potassium usnate, a water-soluble usnic acid salt, shows enhanced bioavailability and inhibits invasion and metastasis in colorectal cancer.
Potential clinical application of antioncogene ribozymes for human lung cancer.
Potential lung carcinogenicity induced by chronic exposure to PM2.5 in the rat.
Potentiation of lymphomagenesis by methylnitrosourea in mice transgenic for LMO1 is blocked by O6-alkylguanine DNA-alkyltransferase.
Preclinical activity of EGFR and MEK1/2 inhibitors in the treatment of biliary tract carcinoma.
Preclinical antitumor activity of BMS-214662, a highly apoptotic and novel farnesyltransferase inhibitor.
Preclinical in vivo evaluation of efficacy, pharmacokinetics, and pharmacodynamics of a novel MEK1/2 kinase inhibitor RO5068760 in multiple tumor models.
Preconditioning of the tumor microenvironment with oncolytic reovirus converts CD3-bispecific antibody treatment into effective immunotherapy.
Prediction of breast cancer proteins involved in immunotherapy, metastasis, and RNA-binding using molecular descriptors and artificial neural networks.
Predictive factors for outcome in a phase II study of gefitinib in second-line treatment of advanced esophageal cancer patients.
Predictive factors for the efficacy of cetuximab plus chemotherapy as salvage therapy in metastatic gastric cancer patients.
Predictive Molecular Tumour Testing: What Are the Obstacles between Bench and Bedside?
Predictive signatures inform the effective repurposing of Decitabine to treat K-RAS-dependent Pancreatic Ductal Adenocarcinoma.
Predictors of gefitinib outcomes in advanced non-small cell lung cancer (NSCLC): Study of a comprehensive panel of molecular markers.
Preferential carcinogen-DNA adduct formation at codons 12 and 14 in the human K-ras gene and their possible mechanisms.
Preferential DNA damage and poor repair determine ras gene mutational hotspot in human cancer.
Preneoplastic potential of morphologically distinct transformed foci induced by 3-methylcholanthrene.
Preresectional chemotherapy in stage IIIA non-small-cell lung cancer: a 7-year assessment of a randomized controlled trial.
Presence of activated ras correlates with increased cysteine proteinase activities in human colorectal carcinomas.
Prevalence and clinical significance of combined K-ras mutation and p53 aberration in pancreatic adenocarcinoma.
Prevalence of activating K-ras mutations in the evolutionary stages of neoplasia in intraductal papillary mucinous tumors of the pancreas.
Prevalence of K-ras Codon 12 Mutations in Indian Patients with Head and Neck Cancer.
Prevalence of K-RAS mutations and CA125 tumor marker in patients with ovarian carcinoma.
Prevalence of K-Ras mutations in hepatocellular carcinoma: A Turkish Oncology Group pilot study.
Prevalence of p53 overexpression or mutations, but not k-ras mutations, in recurrent patients affected by colorectal-carcinoma.
Prevalence of RAS oncogene mutation in head and neck carcinomas.
Prevention of K-Ras- and Pten-mediated intravaginal tumors by treatment with camptothecin-loaded PLGA nanoparticles.
Prevention of lung cancer progression by bexarotene in mouse models.
Prevention of orthotopic human lung cancer growth by intratracheal instillation of a retroviral antisense K-ras construct.
Primary cancer of the small intestine and mutational analysis of the K-ras and p53 genes.
Primary epithelial-myoepithelial carcinoma of the pituitary gland.
Primary lung tumors in mice: an experimentally manipulable model of human adenocarcinoma.
Primitive neuroectodermal tumors after prophylactic central nervous system irradiation in children. Association with an activated K-ras gene.
Principles of K-Ras effector organization and the role of oncogenic K-Ras in cancer initiation through G1 cell cycle deregulation.
Pro-apoptotic activity of oncogenic H-Ras for histone deacetylase inhibitor to induce apoptosis of human cancer HT29 cells.
Proapoptotic ability of oncogenic H-Ras to facilitate apoptosis induced by histone deacetylase inhibitors in human cancer cells.
Problems in the diagnosis and treatment of a so-called mucin-producing tumor of the pancreas.
Procathepsin L secretion, which triggers tumour progression, is regulated by Rab4a in human melanoma cells.
Production of spindle cell carcinoma by transduction of H-Ras 61L into immortalized human mammary epithelial cells.
Professor Frank McCormick: K-Ras proteins offer new opportunities for therapeutic intervention against human cancers.
Profiling gene expression induced by protease-activated receptor 2 (PAR2) activation in human kidney cells.
Profiling of transcripts and proteins modulated by K-ras oncogene in the lung tissues of K-ras transgenic mice by omics approaches.
Progesterone and calcitriol reduce invasive potential of endometrial cancer cells by targeting ARF6, NEDD9 and MT1-MMP.
Prognosis of human pancreatic adenocarcinoma: review of clinical and histopathological variables and possible uses of new molecular methods.
Prognostic and immunological role of Ras-related protein Rap1b in pan-cancer.
Prognostic and predictive factors in colorectal cancer.
Prognostic and Predictive Markers of Benefit from Adjuvant Chemotherapy in Early-Stage Non-small Cell Lung Cancer.
Prognostic and predictive molecular markers in colorectal carcinoma.
Prognostic and predictive value of K-RAS mutations in non-small cell lung cancer.
Prognostic and predictive values of pERK1/2 and pAkt-1 expression in non-small cell lung cancer patients treated with adjuvant chemotherapy.
Prognostic impact of K-RAS mutational status and primary tumor location in patients undergoing resection for colorectal cancer liver metastases: an update.
Prognostic impact of K-RAS mutational status and primary tumour location in patients undergoing resection for colorectal cancer liver metastases: A METHEPAR analysis (multicentre study in Argentina).
Prognostic implications of routine, immunohistochemical, and molecular staging in resectable pancreatic adenocarcinoma.
Prognostic importance of tumor location and anti-EGFR therapy in patients with K-RAS wild type metastatic colorectal cancer.
Prognostic role of K-ras in patients with progressive colon cancer who received treatment with Marimastat (BB2516).
Prognostic role of Rab27A and Rab27B expression in patients with non-small cell lung carcinoma.
Prognostic significance of DNA aneuploidy and p21 ras oncoprotein expression in colorectal cancer and their role in the determination of treatment modalities.
Prognostic Significance of K- ras Codon 12 Mutation in Patients with Resected Gallbladder Cancer.
Prognostic significance of K-ras and TP53 mutations in the role of adjuvant chemotherapy on survival in patients with Dukes C colon cancer.
Prognostic significance of K-ras mutations in pancreatic cancer: a meta-analysis.
Prognostic significance of K-ras, p53, bcl-2, PCNA, CD34 in radically resected non-small cell lung cancers.
Prognostic Significance of Rab27A and Rab27B Expression in Esophageal Squamous Cell Cancer.
Prognostic significance of ras/p21 alterations in human ovarian cancer.
Prognostic value of disseminated colorectal tumor cells in the liver: results of follow-up examinations.
Prognostic value of genetically diagnosed lymph node micrometastasis in non-small cell lung carcinoma cases.
Prognostic value of k-ras 12 genotypes in patients with advanced nonsmall cell lung-cancer receiving Carboplatin with either intravenous or chronic oral dose Etoposide.
Prognostic value of K-ras mutation status and subtypes in endoscopic ultrasound-guided fine-needle aspiration specimens from patients with unresectable pancreatic cancer.
Prognostic value of K-ras mutations and allelic imbalance on chromosome 18q in patients with resected colorectal cancer.
Prognostic value of Rab27B nuclear expression in gastrointestinal stromal tumors.
Prognostic value of replication errors on chromosomes 2p and 3p in non-small-cell lung cancer.
Progress in the therapeutic inhibition of Cdc42 signalling.
Progression and multiple events in radiation carcinogenesis of rat skin.
Progression of mouse skin carcinogenesis is associated with the orchestrated deregulation of miR-200 family members, miR-205 and their common targets.
Progression of squamous carcinoma cells to spindle carcinomas of mouse skin is associated with an imbalance of H-ras alleles on chromosome 7.
Proliferative heterogeneity of human renal cell carcinomas and prevalence of ras gene point mutations.
Prolonged survival in pancreatic cancer patients with increased regucalcin gene expression: Overexpression of regucalcin suppresses the proliferation in human pancreatic cancer MIA PaCa-2 cells in vitro.
Promoter hypermethylation of the DNA repair gene O(6)-methylguanine-DNA methyltransferase is associated with the presence of G:C to A:T transition mutations in p53 in human colorectal tumorigenesis.
Promoter hypermethylation of the O6-methylguanine-DNA methyltransferase gene: more common in lung adenocarcinomas from never-smokers than smokers and associated with tumor progression.
Promoter hypermethylation of tumor-related genes in the progression of colorectal neoplasia.
Promoter methylation of RASSF1A and DAPK and mutations of K-ras, p53, and EGFR in lung tumors from smokers and never-smokers.
Promoting effect of a high-fat/high-protein diet in DMBA-induced ductal pancreatic cancer in rats.
Prophylactic intervention of probiotics (L.acidophilus, L.rhamnosus GG) and celecoxib modulate Bax-mediated apoptosis in 1,2-dimethylhydrazine-induced experimental colon carcinogenesis.
Protection against malignant progression of spontaneously developing liver tumors in transgenic mice expressing O(6)-methylguanine-DNA methyltransferase.
Protein Kinase C {delta} Is a Downstream Effector of Oncogenic K-ras in Lung Tumors.
Protein kinase C-alpha signals P115RhoGEF phosphorylation and RhoA activation in TNF-alpha-induced mouse brain microvascular endothelial cell barrier dysfunction.
Protein kinase C? is a new prognostic factor in gastric cancer.
Protein profile of tax-associated complexes.
Protein tyrosine kinase 6 regulates mammary gland tumorigenesis in mouse models.
Protein tyrosine phosphatase receptor-like genes are frequently hypermethylated in sporadic colorectal cancer.
Proteomic analysis of eIF-5A in lung adenocarcinomas.
Proteomic and Interactome Approaches Reveal PAK4, PHB-2, and 14-3-3? as Targets of Overactivated Cdc42 in Cellular Responses to Genomic Instability.
Proteomic and phosphoproteomic alterations in benign, premalignant and tumor human breast epithelial cells and xenograft lesions: biomarkers of progression.
Proteomic Identification of Cysteine Cathepsin Substrates Shed from the Surface of Cancer Cells.
Proteomic profiling reveals the prognostic value of adenomatous polyposis coli-end-binding protein 1 in hepatocellular carcinoma.
Proteomics Analysis Reveals Novel RASSF2 Interaction Partners.
Proto-oncogene activation in liver tumors of hepatocarcinogenesis-resistant strains of mice.
Proto-oncogene ras GTPase-linked induction of glutathione-S-transferase by growth factors in PC12 cells.
PTEN dosage is essential for neurofibroma development and malignant transformation.
Pten inactivation accelerates oncogenic K-ras-initiated tumorigenesis in a mouse model of lung cancer.
PTEN loss of expression predicts cetuximab efficacy in metastatic colorectal cancer patients.
PTEN mutation, expression and LOH at its locus in ovarian carcinomas. Relation to TP53, K-RAS and BRCA1 mutations.
Pulmonary carcinogenesis in transgenic mice.
Pulmonary tumors associated with the JC virus T-antigen in a transgenic mouse model.
Putative contribution of CD56 positive cells in cetuximab treatment efficacy in first-line metastatic colorectal cancer patients.
Qian Yang Yu Yin Granule-containing serum inhibits angiotensin II-induced proliferation, reactive oxygen species production, and inflammation in human mesangial cells via an NADPH oxidase 4-dependent pathway.
Qualitative and quantitative changes in nuclear DNA and phenotypic gene expression in human malignant skin tumors during their progression.
Quantitative analysis of K-ras gene mutation in pancreatic tissue obtained by endoscopic ultrasonography-guided fine needle aspiration: clinical utility for diagnosis of pancreatic tumor.
Quantitative and qualitative characterization of plasma DNA identifies primary and recurrent colorectal cancer.
Quantitative detection of mutant alleles of the K-ras gene with minor groove binder-conjugated fluorogenic DNA probes.
Quantitative determination of K-ras mutations in pancreatic juice for diagnosis of pancreatic cancer using hybridization protection assay.
Quaternized chitosan particles as ion exchange supports for label-free DNA detection using PNA probe and MALDI-TOF mass spectrometry.
Quinacrine causes apoptosis in human cancer cell lines through caspase-mediated pathway and regulation of small-GTPase.
R(h)oads to microvesicles.
R-Ketorolac Targets Cdc42 and Rac1 and Alters Ovarian Cancer Cell Behaviors Critical for Invasion and Metastasis.
R-Ras promotes metastasis of cervical cancer epithelial cells.
Rab GTPases as regulators of endocytosis, targets of disease and therapeutic opportunities.
Rab GTPases implicated in inherited and acquired disorders.
Rab11 collaborates E-cadherin to promote collective cell migration and indicates a poor prognosis in colorectal carcinoma.
Rab11 Functions as an Oncoprotein via Nuclear Factor kappa B (NF-?B) Signaling Pathway in Human Bladder Carcinoma.
Rab11 regulates E-cadherin expression and induces cell transformation in colorectal carcinoma.
Rab11-FIP1C is a critical negative regulator in ErbB2-mediated mammary tumor progression.
RAB11-Mediated Trafficking and Human Cancers: An Updated Review.
Rab11a regulates MMP2 expression by activating the PI3K/AKT pathway in human hepatocellular carcinoma cells.
Rab11FIP proteins link endocytic recycling vesicles for cytoskeletal transport and tethering.
Rab13 and the Regulation of Cancer Cell Behavior.
Rab14 is overexpressed in ovarian cancers and promotes ovarian cancer proliferation through Wnt pathway.
Rab18 overexpression promotes proliferation and chemoresistance through regulation of mitochondrial function in human gastric cancer.
RAB18 promotes proliferation and metastasis in hepatocellular carcinoma.
Rab18 Regulates Proliferation, Invasion and Cisplatin Sensitivity Through STAT3 Signaling in Head and Neck Squamous Cell Carcinoma.
Rab23 activities and human cancer-emerging connections and mechanisms.
Rab23 contributes to the progression of colorectal cancer via protein kinase B and extracellular signal-regulated kinase signaling pathways.
Rab23 is a potential biological target for treating hepatocellular carcinoma.
Rab23 is overexpressed in human astrocytoma and promotes cell migration and invasion through regulation of Rac1.
Rab23 is overexpressed in human bladder cancer and promotes cancer cell proliferation and invasion.
Rab23 Promotes Hepatocellular Carcinoma Cell Migration Via Rac1/TGF-? Signaling.
Rab23 promotes squamous cell carcinoma cell migration and invasion via integrin ?1/Rac1 pathway.
Rab23 promotes the cisplatin resistance of ovarian cancer via the Shh-Gli-ABCG2 signaling pathway.
Rab23's genetic structure, function and related diseases: a review.
RAB23, regulated by miR-92b, promotes the progression of esophageal squamous cell carcinoma.
Rab25 GTPase: Functional roles in cancer.
Rab25 increases cellular ATP and glycogen stores protecting cancer cells from bioenergetic stress.
Rab25 Small GTPase Mediates Secretion of Tumor Necrosis Factor Receptor Superfamily Member 11b (osteoprotegerin) Protecting Cancer Cells from Effects of TRAIL.
Rab25 upregulation correlates with the proliferation, migration, and invasion of renal cell carcinoma.
RAB27A is an independent prognostic factor in clear cell renal cell carcinoma.
Rab27A mediated by NF-?B promotes the stemness of colon cancer cells via up-regulation of cytokine secretion.
Rab27A overexpression promotes bladder cancer proliferation and chemoresistance through regulation of NF-?B signaling.
Rab27a plays a dual role in metastatic propensity of pancreatic cancer.
RAB27A promotes melanoma cell invasion and metastasis via regulation of pro-invasive exosomes.
Rab27a supports exosome-dependent and -independent mechanisms that modify the tumor microenvironment and can promote tumor progression.
RAB27A, RAB27B and VPS36 are downregulated in advanced prostate cancer and show functional relevance in prostate cancer cells.
RAB27A-dependent release of exosomes by liver cancer stem cells induces Nanog expression in their differentiated progenies and confers regorafenib resistance.
Rab27b contributes to radioresistance and exerts a paracrine effect via epiregulin in glioblastoma.
Rab27b Is a Potential Indicator for Lymph Node Metastasis and Unfavorable Prognosis in Lung Adenocarcinoma.
Rab27b is a potential predictor for metastasis and prognosis in colorectal cancer.
RAB27B-activated secretion of stem-like tumor exosomes delivers the biomarker microRNA-146a-5p, which promotes tumorigenesis and associates with an immunosuppressive tumor microenvironment in colorectal cancer.
Rab35 GTPase and cancer: Linking membrane trafficking to tumorigenesis.
Rab35 GTPase: A Central Regulator of Phosphoinositides and F-actin in Endocytic Recycling and Beyond.
Rab35-dependent extracellular nanovesicles are required for induction of tumour supporting stroma.
Rab35: GEFs, GAPs and Effectors.
Rab37 in lung cancer mediates exocytosis of soluble ST2 and thus skews macrophages toward tumor-suppressing phenotype.
Rab37 mediates exocytosis of secreted frizzled-related protein 1 to inhibit Wnt signaling and thus suppress lung cancer stemness.
RAB38 confers a poor prognosis, associated with malignant progression and subtype preference in glioma.
RAB38 Facilitates Energy Metabolism and Counteracts Cell Death in Glioblastoma Cells.
RAB38 is a potential prognostic factor for tumor recurrence in non-small cell lung cancer.
RAB38 promotes bladder cancer growth by promoting cell proliferation and motility.
RAB39A: a Rab small GTPase with a prominent role in cancer stemness.
Rab3a promotes brain tumor initiation and progression.
Rab3IP interacts with SSX2 and enhances the invasiveness of gastric cancer cells.
RAB7 controls melanoma progression by exploiting a lineage-specific wiring of the endolysosomal pathway.
RAB9A Plays an Oncogenic Role in Human Liver Cancer Cells.
Rac GTPase activating protein 1 promotes gallbladder cancer via binding DNA ligase 3 to reduce apoptosis.
Rac-GAP-dependent inhibition of breast cancer cell proliferation by {beta}2-chimerin.
Rac1 and Cdc42 are regulators of HRasV12-transformation and angiogenic factors in human fibroblasts.
Rac1 and Cdc42 are required for phagocytosis, but not NF-kappaB-dependent gene expression, in macrophages challenged with Pseudomonas aeruginosa.
Rac1 and Cdc42 GTPases regulate shear stress-driven ?-catenin signaling in osteoblasts.
Rac1 as a potential therapeutic target for chemo-radioresistant head and neck squamous cell carcinomas (HNSCC).
Rac1 expression in epithelial ovarian cancer: effect on cell EMT and clinical outcome.
Rac1 is required for Prkar1a-mediated Nf2 suppression in Schwann cell tumors.
RAC1 Takes the Lead in Solid Tumors.
Rac1 targeting suppresses human non-small cell lung adenocarcinoma cancer stem cell activity.
Rac1-PAK1 regulation of Rab11 cycling promotes junction destabilization.
Rac1/?-Catenin Signalling Pathway Contributes to Trophoblast Cell Invasion by Targeting Snail and MMP9.
RAC1B Regulation of TGFB1 Reveals an Unexpected Role of Autocrine TGF?1 in the Suppression of Cell Motility.
RAC1B: A Rho GTPase with Versatile Functions in Malignant Transformation and Tumor Progression.
RacGAP1 ameliorates acute kidney injury by promoting proliferation and suppressing apoptosis of renal tubular cells.
RacGTPase-activating protein 1 interacts with hepatitis C virus polymerase NS5B to regulate viral replication.
Rad GTPase inhibits the NF?B pathway through interacting with RelA/p65 to impede its DNA binding and target gene transactivation.
Radiation and chemical activation of ras oncogenes in different mouse strains.
Radiation sensitization of human cancer cells in vivo by inhibiting the activity of PI3K using LY294002.
Radiation-associated and 'spontaneous' human thyroid carcinomas show a different pattern of ras oncogene mutation.
Radiation-induced cell transformation: transformation efficiencies of different types of ionizing radiation and molecular changes in radiation transformants and tumor cell lines.
Radioresistance of K-Ras mutated human tumor cells is mediated through EGFR-dependent activation of PI3K-AKT pathway.
Radiosensitivity of small-cell lung cancer xenografts compared with activity of c-myc, N-myc, L-myc, c-raf-1 and K-ras proto-oncogenes.
Radiosensitization of human tumor cell lines induced by the adenovirus-mediated expression of an anti-Ras single-chain antibody fragment.
Radiosensitizing Effects of the Prenyltransferase Inhibitor AZD3409 against RAS Mutated Cell Lines.
RAF dimer inhibition enhances the antitumor activity of MEK inhibitors in K-RAS mutant tumors.
Ral and Rheb GTPase activating proteins integrate mTOR and GTPase signaling in aging, autophagy, and tumor cell invasion.
Ral GTPase down-regulation stabilizes and reactivates p53 to inhibit malignant transformation.
RalA-exocyst complex regulates integrin-dependent membrane raft exocytosis and growth signaling.
RAN and YBX1 are required for cell proliferation and IL-4 expression and linked to poor prognosis in oral squamous cell carcinoma.
Ran, a small GTPase gene, encodes cytotoxic T lymphocyte (CTL) epitopes capable of inducing HLA-A33-restricted and tumor-reactive CTLs in cancer patients.
Rap GTPase Interactor: A Potential Marker for Cancer Prognosis Following Kidney Transplantation.
Rap1 activity is elevated in malignant astrocytomas independent of tuberous sclerosis complex-2 gene expression.
Rap1a null mice have altered myeloid cell functions suggesting distinct roles for the closely related Rap1a and 1b proteins.
Rap1A promotes esophageal squamous cell carcinoma metastasis through the AKT signaling pathway.
Rap1A promotes ovarian cancer metastasis via activation of ERK/p38 and notch signaling.
Rap1b enhances the invasion and migration of hepatocellular carcinoma cells by up-regulating Twist 1.
RAP1B, a DVL2 binding protein, activates Wnt/beta-catenin signaling in esophageal squamous cell carcinoma.
Rap1GAP regulates renal cell carcinoma invasion.
Rap2a is a novel target gene of p53 and regulates cancer cell migration and invasion.
Rap2A Is Upregulated in Invasive Cells Dissected from Follicular Thyroid Cancer.
RAP2A promotes apoptosis resistance of hepatocellular carcinoma cells via the mTOR pathway.
Rap2a serves as a potential prognostic indicator of renal cell carcinoma and promotes its migration and invasion through up-regulating p-Akt.
Rap2c as a Novel Biomarker for Predicting Poor Prognosis in Glioma.
Rapalogs can promote cancer cell stemness in vitro in a Galectin-1 and H-ras-dependent manner.
Rapamycin Prevents Early Onset of Tumorigenesis in an Oral-Specific K-ras and p53 Two-Hit Carcinogenesis Model.
Rapid and large-scale method to detect K-ras gene mutations in tumor samples.
Rapid detection of K-ras gene mutations in canine lung cancer using single-strand conformational polymorphism analysis.
Rapid detection of low-abundance K-ras mutation in stools of colorectal cancer patients using chip-based temperature gradient capillary electrophoresis.
Rapid detection of ras oncogenes in human tumors: applications to colon, esophageal, and gastric cancer.
Raptor, a binding partner of target of rapamycin.
Rare activation of ras oncogenes in radiation induced rat skin tumors.
Rare codons capacitate Kras-driven de novo tumorigenesis.
Rare Streptomyces sp. polyketides as modulators of K-Ras localisation.
Ras activation in human breast cancer.
Ras activation in retinal progenitor cells induces tumor formation in the eye.
Ras activity levels control the development of pancreatic diseases.
Ras and autophagy in cancer development and therapy.
ras and myc analysis in primary and metastatic colorectal carcinomas.
Ras and relatives--job sharing and networking keep an old family together.
Ras CAAX peptidomimetic FTI 276 selectively blocks tumor growth in nude mice of a human lung carcinoma with K-Ras mutation and p53 deletion.
ras gene activation and infrequent mutation in papillary serous carcinoma of the peritoneum.
Ras gene activation in human small intestinal tumors.
Ras gene activation in malignant cells of human ovarian carcinoma peritoneal fluids.
ras gene activation in rat tumors induced by benzidine congeners and derived dyes.
ras Gene mutations and expression of Ras signal transduction mediators in gastric adenocarcinomas.
ras gene mutations in ethmoid sinus adenocarcinoma: prognostic implications.
ras gene mutations in human endometrial carcinoma.
Ras gene mutations in intraductal papillary neoplasms of the pancreas. Analysis in five cases.
ras gene mutations in salivary gland tumors.
Ras in cancer and developmental diseases.
Ras interference as cancer therapy.
Ras mutation cooperates with ?-catenin activation to drive bladder tumourigenesis.
Ras mutational status is a biomarker for resistance to EGFR inhibitors in colorectal carcinoma.
RAS Mutations Affect Tumor Necrosis Factor-Induced Apoptosis in Colon Carcinoma Cells via ERK-Modulatory Negative and Positive Feedback Circuits Along with Non-ERK Pathway Effects.
ras mutations and expression in head and neck squamous cell carcinomas.
Ras mutations are uncommon in sporadic thyroid cancer in children and young adults.
ras mutations in 2-acetylaminofluorene-induced lung and liver tumors from C3H/HeJ and (C3H x A/J)F1 mice.
Ras mutations in methylclofenapate-induced B6C3F1 and C57BL/10J mouse liver tumours.
Ras oncogene activation during hepatocarcinogenesis in B6C3F1 male mice by dichloroacetic and trichloroacetic acids.
Ras oncogene activation in benign and malignant colorectal tumours.
ras oncogene activation in human ovarian carcinoma.
Ras oncogene mutations in benign and malignant thyroid neoplasms.
Ras oncogene point mutation: an infrequent event in bronchioloalveolar cancer.
ras proto-oncogene activation in dichloroacetic acid-, trichloroethylene- and tetrachloroethylene-induced liver tumors in B6C3F1 mice.
Ras proto-oncogene activation in liver and lung tumors from B6C3F1 mice exposed chronically to methylene chloride.
Ras regulation of DNA-methylation and cancer.
Ras signaling and therapies.
Ras signaling in tumor necrosis factor-induced apoptosis.
Ras Transformation Overrides a Proliferation Defect Induced by Tpm3.1 Knockout.
Ras up-regulation of cyclooxygenase-2.
Ras-related protein Rap2c promotes the migration and invasion of human osteosarcoma cells.
RAS/RAF/MEK Inhibitors in Oncology.
RasGRP1 transgenic mice develop cutaneous squamous cell carcinomas in response to skin wounding: potential role of granulocyte colony-stimulating factor.
RasIns: Genetically Encoded Intrabodies of Activated Ras Proteins.
RASL11A, member of a novel small monomeric GTPase gene family, is down-regulated in prostate tumors.
RASL11B gene enhances hyaluronic acid-mediated chondrogenic differentiation in human amniotic mesenchymal stem cells via the activation of Sox9/ERK/smad signals.
Rasl11b knock down in zebrafish suppresses one-eyed-pinhead mutant phenotype.
RASSF1A Deficiency Enhances RAS-Driven Lung Tumorigenesis.
RASSF1A gene inactivation in non-small cell lung cancer and its clinical implication.
RASSF1A methylation and K-ras and B-raf mutations and recurrent endometrial cancer.
RASSF1A Suppresses the Invasion and Metastatic Potential of Human Non-Small Cell Lung Cancer Cells by Inhibiting YAP Activation through the GEF-H1/RhoB Pathway.
RASSF5: An MST activator and tumor suppressor in vivo but opposite in vitro.
RASSF6 is a novel member of the RASSF family of tumor suppressors.
Rational combination of MEK inhibitor and the STAT3 pathway modulator for the therapy in K-Ras mutated pancreatic and colon cancer cells.
Rce1 suppresses invasion and metastasis of hepatocellular carcinoma via epithelial-mesenchymal transition induced by the TGF-?1/H-Ras signaling pathway.
Re: Role of oncogenic K-Ras in cancer stem cell activation by aberrant Wnt/?-catenin signaling.
Reactive oxygen species and lung tumorigenesis by mutant K-ras: a working hypothesis.
Real-time study of E-cadherin and membrane dynamics in living animals: implications for disease modeling and drug development.
Reappraisal of K-ras and p53 gene mutations in the recurrence of Dukes' B2 rectal cancer after curative resection.
Recent Advances in Developing K-Ras Plasma Membrane Localization Inhibitors.
Recent Advances in Identifying Biomarkers and High-Affinity Aptamers for Gynecologic Cancers Diagnosis and Therapy.
Recent advances in molecular genetics of colorectal cancer.
Recent discoveries in cancer genetics of exocrine pancreatic neoplasia.
Recent progress in developing small molecule inhibitors designed to interfere with ras membrane association: toward inhibiting K-Ras and N-Ras functions.
Recent progress in targeting the Raf/MEK/ERK pathway with inhibitors in cancer drug discovery.
Recombinant adenovirus encoding H-ras ribozyme induces apoptosis in laryngeal cancer cells through caspase- and mitochondria-dependent pathways.
Recruitment of Tiam1 to Semaphorin 4D Activates Rac and Enhances Proliferation, Invasion, and Metastasis in Oral Squamous Cell Carcinoma.
Recurrent activating mutation in PRKACA in cortisol-producing adrenal tumors.
Recurrent breast cancer and an adenocarcinoma of the lung occurring in one patient: c-myc oncogene amplification and K-ras codon 12 point mutation as tumour markers.
Recycling Endosomes in Mature Epithelia Restrain Tumorigenic Signaling.
Redox biology in normal cells and cancer: Restoring function of the redox/Fyn/c-Cbl pathway in cancer cells offers new approaches to cancer treatment.
Reduced cell death, invasive and angiogenic features conferred by BRCA1-deficiency in mammary epithelial cells transformed with H-Ras.
Reduced likelihood of metastases in patients with microsatellite-unstable colorectal cancer.
Reduced lung tumorigenesis in human methylguanine DNA--methyltransferase transgenic mice achieved by expression of transgene within the target cell.
Reduced WNT5A signaling in melanoma cells favors an amoeboid mode of invasion.
Reduction in IkappaB kinase alpha expression promotes the development of skin papillomas and carcinomas.
Reduction of p53 gene dosage does not increase initiation or promotion but enhances malignant progression of chemically induced skin tumors.
Refined mapping of 12q13-q15 amplicons in human malignant gliomas suggests CDK4/SAS and MDM2 as independent amplification targets.
Regulating Cdc42 and Its Signaling Pathways in Cancer: Small Molecules and MicroRNA as New Treatment Candidates.
Regulation and functional significance of CDC42 alternative splicing in ovarian cancer.
Regulation of cancer cell motility through actin reorganization.
Regulation of CXCR4/AKT-signaling-induced cell invasion and tumor metastasis by RhoA, Rac-1, and Cdc42 in human esophageal cancer.
Regulation of H-Ras-driven MAPK signaling, transformation and tumorigenesis, but not PI3K signaling and tumor progression, by plasma membrane microdomains.
Regulation of K-Ras4B Membrane Binding by Calmodulin.
Regulation of mixed lineage kinase 3 is required for Neurofibromatosis-2-mediated growth suppression in human cancer.
Regulation of p21/ras protein expression by diallyl sulfide in DMBA induced neoplastic changes in mouse skin.
Regulation of pancreatic cancer growth by superoxide.
Regulation of PD-L1 expression in K-ras-driven cancers through ROS-mediated FGFR1 signaling.
Regulation of the small GTPase Ran by miR-802 modulates proliferation and metastasis in colorectal cancer cells.
Regulation of vascular endothelial growth factor by the Wnt and K-ras pathways in colonic neoplasia.
Relationship Between Expression of ras p21 Oncoprotein and Mutation Status of the K-ras Gene in Sporadic Colorectal Cancer Patients in Tunisia.
Relationship between K-ras oncogene activation and smoking in adenocarcinoma of the human lung.
Relationship between overexpression of ras p21 oncoprotein and K-ras codon 12 and 13 mutations in Turkish colorectal cancer patients.
Relationship between the formation of promutagenic adducts and the activation of the K-ras protooncogene in lung tumors from A/J mice treated with nitrosamines.
Relationship of family cancer history to the expression of p53, p21WAF-1, HER-2/neu, and K-ras mutation in pancreatic adenocarcinoma.
Relationship of levels and kinetics of H-ras expression to transformed phenotype and loss of TGF-beta 1-mediated growth regulation in intestinal epithelial cells.
Relationship of the K-ras/c-mos expression patterns with angiogenesis in non-small cell lung carcinomas.
Relationships of DNA adduct formation, K-ras activating mutations and tumorigenic activities of 6-nitrochrysene and its metabolites in the lungs of CD-1 mice.
Release of autoinhibition of ASEF by APC leads to CDC42 activation and tumor suppression.
Release of tumor necrosis factor-á from macrophages is mediated by small GTPase Rab37.
Relevance of DNA repair to carcinogenesis and cancer therapy.
Relevance of Ras gene mutations in the context of the molecular heterogeneity of multiple myeloma.
Relevance of small GTPase Rac1 pathway in drug and radio-resistance mechanisms: Opportunities in cancer therapeutics.
Remodeling cancer stemness by collagen/fibronectin via the AKT and CDC42 signaling pathway crosstalk in glioma.
Renal gene expression in embryonic and newborn diabetic mice.
Report on carcinogens monograph on cumene.
Repositioning metformin in cancer: genetics, drug targets, and new ways of delivery.
Requirement of the NF-kappaB subunit p65/RelA for K-Ras-induced lung tumorigenesis.
Research strategy in industrial toxicology.
Residue interaction networks of K-Ras protein with water molecules identifies the potential role of switch II and P-loop.
Response to erlotinib in a patient with lung adenocarcinoma harbouring the EML4-ALK translocation: A case report.
Response to First-Line Chemotherapy in Patients With Non-Small-Cell Lung Cancer According to Epidermal Growth Factor Receptor and K-RAS Mutation Status.
Restoration of thrombospondin 1 expression in tumor cells harbouring mutant ras oncogene by treatment with low doses of doxycycline.
Restriction endonuclease-mediated selective polymerase chain reaction: a novel assay for the detection of K-ras mutations in clinical samples.
Results of a Phase I Trial of 12 Patients With Locally Advanced Pancreatic Carcinoma Combining Gefitinib, Paclitaxel, and 3-Dimensional Conformal Radiation: Report of Toxicity and Evaluation of Circulating K-ras as a Potential Biomarker of Response to Therapy.
Resveratrol inhibits age-dependent spontaneous tumorigenesis by SIRT1-mediated post-translational modulations in the annual fish Nothobranchius guentheri.
Resveratrol inhibits proliferation and migration through SIRT1 mediated post?translational modification of PI3K/AKT signaling in hepatocellular carcinoma cells.
Retraction: "Activated K-Ras and INK4a/Arf Deficiency Promote Aggressiveness of Pancreatic Cancer by Induction of EMT Consistent With Cancer Stem Cell Phenotype" by Wang et al.
Retroviral vector-mediated transduction of K-ras antisense RNA into human lung cancer cells inhibits expression of the malignant phenotype.
Reversal of the malignant phenotype by an anti-ras ribozyme.
Reversibility of proliferative lesions and induction of non-papillary tumors in rat urinary bladder treated with phenylethyl isothiocyanate.
Rho family GTPases cooperate with p53 deletion to promote primary mouse embryonic fibroblast cell invasion.
RHO Family GTPases in the Biology of Lymphoma.
Rho GTPase Activating Protein 9 (ARHGAP9) in Human Cancers.
Rho GTPase activating proteins in cancer phenotypes.
Rho GTPase effector functions in tumor cell invasion and metastasis.
Rho GTPase effectors and NAD metabolism in cancer immune suppression.
Rho GTPase function in tumorigenesis.
Rho GTPase signaling in the development of colorectal cancer.
Rho GTPase Transcriptome Analysis Reveals Oncogenic Roles for Rho GTPase-Activating Proteins in Basal-like Breast Cancers.
Rho GTPases and cancer.
Rho GTPases in cancer radiotherapy and metastasis.
Rho GTPases in cancer: friend or foe?
Rho GTPases in hepatocellular carcinoma.
Rho GTPases in human breast tumours: expression and mutation analyses and correlation with clinical parameters.
Rho GTPases in primary brain tumor malignancy and invasion.
Rho GTPases in transformation and metastasis.
Rho GTPases operating at the Golgi complex: Implications for membrane traffic and cancer biology.
Rho GTPases: Anti- or pro-neoplastic targets?
Rho GTPases: functions and association with cancer.
Rho GTPases: regulation and roles in cancer cell biology.
Rho signaling research: history, current status and future directions.
Rho-associated kinase (ROCK) function is essential for cell cycle progression, senescence and tumorigenesis.
Rho-associated kinase inhibitor reduces tumor recurrence after liver transplantation in a rat hepatoma model.
Rho-GTPase effector ROCK phosphorylates cofilin in actin-meditated cytokinesis during mouse oocyte meiosis.
Rho-kinase/ROCK is involved in cytokinesis through the phosphorylation of myosin light chain and not ezrin/radixin/moesin proteins at the cleavage furrow.
Rho/ROCK/actin signaling regulates membrane androgen receptor induced apoptosis in prostate cancer cells.
Rho?associated kinase inhibitor, Y?27632, inhibits the invasion and proliferation of T24 and 5367 bladder cancer cells.
RhoA controls retinoid signaling by ROCK dependent regulation of retinol metabolism.
RHOA G17V Induces T Follicular Helper Cell Specification and Promotes Lymphomagenesis.
RHOA in Gastric Cancer: Functional Roles and Therapeutic Potential.
RHOA inactivation enhances Wnt signalling and promotes colorectal cancer.
RhoA is associated with invasion and lymph node metastasis in upper urinary tract cancer.
RhoA mutations identified in diffuse gastric cancer.
RhoA triggers a specific signaling pathway that generates transforming microvesicles in cancer cells.
RhoA: a dubious molecule in cardiac pathophysiology.
RhoB differentially controls Akt function in tumor cells and stromal endothelial cells during breast tumorigenesis.
RhoB facilitates c-Myc turnover by supporting efficient nuclear accumulation of GSK-3.
RhoC and ROCKs regulate cancer cell interactions with endothelial cells.
RhoC mediates invasion and migration of CaSki cells through the Rho-associated serine-threonine protein kinase 1 signaling pathway.
RhoC promotes human melanoma invasion in a PI3K/Akt-dependent pathway.
RhoGAPs attenuate cell proliferation by direct interaction with p53 tetramerization domain.
RhoGDI SUMOylation at K138 Increases Its Binding Activity to Rho GTPase and its Inhibiting Cancer Cell Motility.
RhoGDI{alpha}-dependent balance between RhoA and RhoC is a key regulator of cancer cell tumorigenesis.
RhoGTPase signalling at epithelial tight junctions: Bridging the GAP between polarity and cancer.
RhoGTPase Signalling in Cancer Progression and Dissemination.
RhoGTPases and Rho-effectors in hepatocellular carcinoma metastasis: ROCK N'Rho move it.
RhoGTPases and their role in cancer.
RhoJ interacts with the GIT-PIX complex and regulates focal adhesion disassembly.
Rhoj Is a Novel Target for Progression and Invasion of Glioblastoma by Impairing Cytoskeleton Dynamics.
RIAM controls invasion and growth of melanoma cells.
Ribonucleotide reductase R2 gene expression and changes in drug sensitivity and genome stability.
Ribozyme against mutant K-ras mRNA suppresses tumor growth of pancreatic cancer.
RInhibiting K-ras Signaling Reserves the Epithelial-Mesenchymal Transition of Pancreatic Cancer Cells and its Mechanisms.
Risk for K-ras gene mutations in smoking-induced lung cancer is associated with cytochrome P4501A1 and glutathione S-transferase micro1 polymorphisms.
RNA-interference-mediated Cdc42 silencing down-regulates phosphorylation of STAT3 and suppresses growth in human bladder-cancer cells.
ROCK inhibition prevents early mouse embryo development.
Rock2 promotes RCC proliferation by decreasing SCARA5 expression through ?-catenin/TCF4 signaling.
Rock2 stabilizes ?-catenin to promote tumor invasion and metastasis in colorectal cancer.
Role of Apoptotic Regulators in Human Epithelial Ovarian Cancer.
Role of BamHI-A Rightward Frame 1 in Epstein-Barr Virus-Associated Epithelial Malignancies.
Role of Clara cells and type II cells in the development of pulmonary tumors in rats and mice following exposure to a tobacco-specific nitrosamine.
Role of DNA methylation in the activation of proto-oncogenes and the induction of pulmonary neoplasia by nitrosamines.
Role of epidermal growth factor receptor overexpression, K-ras point mutation and c-myc amplification in the carcinogenesis of non-small cell lung cancer.
Role of H-ras gene in chronic liver damage in mice. By using transgenic mice carrying a human C-H-ras proto-oncogene without mutations.
Role of H-ras in the malignant progression of rat tracheal epithelial cells.
Role of Necl-5 in the pathophysiology of colorectal lesions induced by dimethylhydrazine and/or dextran sodium sulphate.
Role of oncogenic K-Ras in cancer stem cell activation by aberrant Wnt/?-catenin signaling.
Role of peptidylarginine deiminase 2 (PAD2) in mammary carcinoma cell migration.
Role of point mutation of the K-ras gene in tumorigenesis of B6C3F1 mouse lung lesions induced by urethane.
Role of Rac1 and Cdc42 in hypoxia induced p53 and von Hippel-Lindau suppression and HIF1alpha activation.
Role of Rac1 Pathway in Epithelial-to-Mesenchymal Transition and Cancer Stem-like Cell Phenotypes in Gastric Adenocarcinoma.
Role of Rac1/WAVE2 Signaling in Mediating the Inhibitory Effects of ?-Tocotrienol on Mammary Cancer Cell Migration and Invasion.
Role of RAF/MEK/ERK pathway, p-STAT-3 and Mcl-1 in sorafenib activity in human pancreatic cancer cell lines.
Role of Rap1B and Tumor Suppressor PTEN in the Negative Regulation of Lysophosphatidic Acid-induced Migration by Isoproterenol in Glioma Cells.
Role of ras protooncogene activation in the formation of spontaneous and nitrosamine-induced lung tumors in the resistant C3H mouse.
Role of Rho GTPases in breast cancer.
Role of the DPC4 tumor suppressor gene in adenocarcinoma of the ampulla of Vater: analysis of 140 cases.
Role of tumor markers and mutations in cells and pancreatic juice in the diagnosis of pancreatic cancer.
Roles of E-cadherin and Noncoding RNAs in the Epithelial-mesenchymal Transition and Progression in Gastric Cancer.
Roles of Small GTPases in Acquired Tamoxifen Resistance in MCF-7 Cells Revealed by Targeted, Quantitative Proteomic Analysis.
RRAD inhibits the Warburg effect through negative regulation of the NF-?B signaling.
Runx3 is required for the differentiation of lung epithelial cells and suppression of lung cancer.
S-Adenosylmethionine decarboxylase gene expression is regulated by the cAMP signal transduction pathway in H-ras transformed fibrosarcoma cells capable of malignant progression.
S-adenosylmethionine decarboxylase gene expression is regulated by the cAMP signal transduction pathway in H-ras transformed fibrosarcoma cells capable of malignant progression.
S-adenosylmethionine inhibits the growth of cancer cells by reversing the hypomethylation status of c-myc and H-ras in human gastric cancer and colon cancer.
S100A7 has an oncogenic role in oral squamous cell carcinoma by activating p38/MAPK and RAB2A signaling pathway.
Salinomycin inhibits growth of pancreatic cancer and cancer cell migration by disruption of actin stress fiber integrity.
Sampling technique influences the detection of K-ras mutations in normal appearing mucosa of colorectal cancer patients.
SAP and XIAP deficiency in hemophagocytic lymphohistiocytosis.
Saponins extracted from by-product of Asparagus officinalis L. suppress tumour cell migration and invasion through targeting Rho GTPase signalling pathway.
Saponins extracted from by?product of Asparagus officinalis L. suppress tumour cell migration and invasion through targeting Rho GTPase signalling pathway
Screening for Combination Cancer Therapies With Dynamic Fuzzy Modeling and Multi-Objective Optimization.
Screening of H-ras gene point mutations in 50 cases of bladder carcinoma.
Screening of human bladder tumors and urine sediments for the presence of H-ras mutations.
Second primary or recurrence? Comparative patterns of p53 and K-ras mutations suggest that serous borderline ovarian tumors and subsequent serous carcinomas are unrelated tumors.
Secondary malignant giant-cell tumour of bone: molecular abnormalities of p53 and H-ras gene correlated with malignant transformation.
Selective 'stencil'-aided pre-PCR cleavage of wild-type sequences as a novel approach to detection of mutant K-RAS.
Selective control of membrane ruffling and actin plaque assembly by the Rho GTPases Rac1 and CDC42 in FcepsilonRI-activated rat basophilic leukemia (RBL-2H3) cells.
Selective cytotoxicity of glycyrrhetinic acid against tumorigenic r/m HM-SFME-1 cells: potential involvement of H-Ras downregulation.
Selective inhibition of growth of tuberous sclerosis complex 2 null cells by atorvastatin is associated with impaired Rheb and Rho GTPase function and reduced mTOR/S6 kinase activity.
Selective killing of K-ras mutant cancer cells by small molecule inducers of oxidative stress.
Selective killing of K-ras-transformed pancreatic cancer cells by targeting NAD(P)H oxidase.
Selective mutation of K-ras by N-ethylnitrosourea shifts from codon 12 to codon 61 during fetal mouse lung maturation.
Selective occurrence of ras mutations in benign and malignant thyroid follicular neoplasms in Taiwan.
Senescence in pancreatic carcinogenesis: from signalling to chromatin remodelling and epigenetics.
Sensitive and specific detection of K-ras mutations in colon tumors by short oligonucleotide mass analysis.
Sensitive and specific KRAS somatic mutation analysis on whole-genome amplified DNA from archival tissues.
Sensitive detection of intracellular environment of normal and cancer cells by autofluorescence lifetime imaging.
Sensitive detection of K-ras mutations augments diagnosis of colorectal cancer metastases in the liver.
Sensitization of Human Pancreatic Cancer Cells Harboring Mutated K-ras to Apoptosis.
SEPT9_i1 regulates human breast cancer cell motility through cytoskeletal and RhoA/FAK signaling pathway regulation.
Sequence Distribution of Acetaldehyde-Derived N(2)-Ethyl-dG Adducts along Duplex DNA.
Sequence of molecular genetic events in colorectal tumorigenesis.
Sequential accumulation of K-ras mutations and p53 overexpression in the progression of pancreatic mucinous cystic neoplasms to malignancy.
Sequential analysis of K-ras mutations in aberrant crypt foci and colonic tumors induced by azoxymethane in Fischer-344 rats on high-risk diet.
Serological cloning of a melanocyte rab guanosine 5'-triphosphate-binding protein and a chromosome condensation protein from a melanoma complementary DNA library.
Sex differences in clinicopathological features of peripheral T1 adenocarcinoma of the lung.
Sex specific function of epithelial STAT3 signaling in pathogenesis of K-ras mutant lung cancer.
Sex-specificity in lung cancer risk.
Signal transduction elements of TC21, an oncogenic member of the R-Ras subfamily of GTP-binding proteins.
Signaling Through Rho GTPase Pathway as Viable Drug Target.
Signet ring basal cell carcinoma. A case study emphasizing the differential diagnosis of neoplasms with signet ring cell formation.
Significance of K-ras codon 12 point mutation in pancreatic juice in the diagnosis of carcinoma of the pancreas.
Significantly increased cortisol secretion in normal adrenocortical cells transfected with K-ras mutants derived from human functional adrenocortical tumors.
Silencing Ras-Related C3 Botulinum Toxin Substrate 1 Inhibits Growth and Migration of Hypopharyngeal Squamous Cell Carcinoma via the P38 Mitogen-Activated Protein Kinase Signaling Pathway.
Silibinin Inhibit Cell Migration through Downregulation of RAC1 Gene Expression in Highly Metastatic Breast Cancer Cell Line.
Silica-induced chronic inflammation promotes lung carcinogenesis in the context of an immunosuppressive microenvironment.
Simplified Reverse Dot Blot Analyses for Detecting of ras Oncogene Mutations.
Simultaneous genotyping of multiplex single nucleotide polymorphisms of the K-ras gene with a home-made kit.
Single-Pattern Convergence of K-ras Mutation Correlates With Surgical Indication of Intraductal Papillary Mucinous Neoplasms.
Single-strand conformation polymorphism analysis by perpendicular temperature-gradient gel electrophoresis.
siRNA agents inhibit oncogene expression and attenuate human tumor cell growth.
siRNA-Encapsulated Hybrid Nanoparticles Target Mutant K-ras and Inhibit Metastatic Tumor Burden in a Mouse Model of Lung Cancer.
Sirt1 protects from K-Ras-driven lung carcinogenesis.
Site specificity of N-methyl-N-nitrosourea-induced transition mutations in the hprt gene.
Site-specific monoubiquitination activates Ras by impeding GTPase-activating protein function.
Six-month exposure of strain A/J mice to cigarette sidestream smoke: cell kinetics and lung tumor data.
Skin hyperkeratosis and papilloma formation in transgenic mice expressing a ras oncogene from a suprabasal keratin promoter.
Small advanced colorectal cancers: clinicopathological characteristics and pathogenetic origin.
Small G protein signalling modulator 2 (SGSM2) is involved in oestrogen receptor-positive breast cancer metastasis through enhancement of migratory cell adhesion via interaction with E-cadherin.
Small GTPase R-Ras Regulates Integrity and Functionality of Tumor Blood Vessels.
Small GTPase Rab21 regulates cell adhesion and controls endosomal traffic of beta1-integrins.
Small GTPase Rab37 targets tissue inhibitor of metalloproteinase 1 for exocytosis and thus suppresses tumour metastasis.
Small GTPase RBJ mediates nuclear entrapment of MEK1/MEK2 in tumor progression.
Small GTPase RBJ promotes cancer progression by mobilizing MDSCs via IL-6.
Small interfering RNAs targeting mutant K-ras inhibit human pancreatic carcinoma cells growth in vitro and in vivo.
Small molecule targeting Cdc42-intersectin interaction disrupts Golgi organization and suppresses cell motility.
Small rho GTPases mediate tumor-induced inhibition of endocytic activity of dendritic cells.
Small-molecule modulation of Ras signaling.
Smurf1 regulation of DAB2IP controls cell proliferation and migration.
Sodium nitroprusside induces H-Ras depalmitoylation and alters the cellular response to hypoxia in differentiated and undifferentiated PC12 cells.
Solid-pseudopapillary tumors of the pancreas are genetically distinct from pancreatic ductal adenocarcinomas and almost always harbor beta-catenin mutations.
Somatic activation of the K-ras oncogene causes early onset lung cancer in mice.
Somatic mutation screening: identification of individuals harboring K-ras mutations with the use of plasma DNA.
Somatic mutations of ERBB2 kinase domain in gastric, colorectal, and breast carcinomas.
Somatic mutations of the adenomatous polyposis coli gene in gastroduodenal tumors from patients with familial adenomatous polyposis.
Somatic mutations, acetylator status, and prognosis in colorectal cancer.
Sonic hedgehog acts at multiple stages during pancreatic tumorigenesis.
Sos-mediated cross-activation of wild-type Ras by oncogenic Ras is essential for tumorigenesis.
Sotorasib: First Approval.
Spatial distribution of IL4 controls iNKT cell-DC crosstalk in tumors.
Specific activation of K-RasG12D allele in the bladder urothelium results in lung alveolar and vascular defects.
Specific codon 13 K-ras mutations are predictive of clinical outcome in colorectal cancer patients, whereas codon 12 K-ras mutations are associated with mucinous histotype.
Specific expression of the ras-related rab3A gene in human normal and malignant neuroendocrine cells.
Specific H-Ras minisatellite alleles in breast cancer susceptibility.
Specific inhibition of K-ras expression and tumorigenicity of lung cancer cells by antisense RNA.
Specific pattern of RAS oncogene mutations in follicular thyroid tumors.
Specific repression of mutant K-RAS by 10-23 DNAzyme: sensitizing cancer cell to anti-cancer therapies.
Spindle cell carcinoma of head and neck: an immunohistochemical and molecular approach to its pathogenesis.
Splice switching an oncogenic ratio of SmgGDS isoforms as a strategy to diminish malignancy.
Spontaneous Tumor Regression in Tasmanian Devils Associated with RASL11A Activation.
Spontaneous uveal amelanotic melanoma in transgenic Tyr-RAS+ Ink4a/Arf-/- mice.
Sprouty2 protein enhances the response to gefitinib through epidermal growth factor receptor in colon cancer cells.
Src promotes GTPase activity of Ras via tyrosine 32 phosphorylation.
srGAP1 mediates the migration inhibition effect of Slit2-Robo1 in colorectal cancer.
Stability of c-K-ras amplification during progression in a patient with adenocarcinoma of the ovary.
Stability of K-ras mutations throughout the natural history of human colorectal cancer.
STAT1, IGF1, RAC1, and MDM2 Are Associated with Recurrence of Giant Cell Tumor of Bone.
Statins and pancreatic cancer.
Staurosporine: A new tool for studying phosphatidylserine trafficking.
Stem cell gene expression changes induced specifically by mutated K-ras.
Stepping out of the flow: capillary extravasation in cancer metastasis.
Stimulated human leukocytes cause activating mutations in the K-ras protooncogene.
Stimulated PI3K-AKT signaling mediated through ligand or radiation-induced EGFR depends indirectly, but not directly, on constitutive K-Ras activity.
Stimulation of Ectopic Bone Formation in Response to BMP-2 by Rho Kinase Inhibitor: A Pilot Study.
Strain-specific spontaneous and NNK-mediated tumorigenesis in Pten+/- mice.
Strategies for Overcoming Inherent and Acquired Resistance to EGFR Inhibitors by Targeting Downstream Effectors in the RAS/PI3K Pathway.
Stress-induced proteins in immune response to cancer.
Stromal cells of endometrial carcinoma promotes proliferation of epithelial cells through the HGF/c-Met/Akt signaling pathway.
Structural and functional analysis of oncogenes and tumor suppressor genes in adult T-cell leukemia/lymphoma shows frequent p53 mutations.
Structural basis for the unique biological function of small GTPase RHEB.
Structure and role of WASP and WAVE in Rho GTPase signalling in cancer.
Structure based drug discovery of Rab38 protein- Identification of antagonists as cancer drug candidates.
Structure guided design and kinetic analysis of highly potent benzimidazole inhibitors targeting the PDE? prenyl binding site.
Structure, signaling and the drug discovery of the Ras oncogene protein.
Structure-based discovery of neoandrographolide as a novel inhibitor of Rab5 to suppress cancer growth.
Studies on the Contribution of Cox-2 Expression in the Progression of Oral Squamous Cell Carcinoma and H-Ras Activation.
Study of the correlation between H-ras mutation and primary hepatocellular carcinoma.
Subunit peptide cancer vaccines targeting activating mutations of the p21 ras proto-oncogene.
Successful xenografting of cryopreserved primary pancreatic cancers.
Sulforaphane, quercetin and catechins complement each other in elimination of advanced pancreatic cancer by miR-let-7 induction and K-ras inhibition.
Superior efficacy of co-treatment with dual PI3K/mTOR inhibitor NVP-BEZ235 and pan-histone deacetylase inhibitor against human pancreatic cancer.
Suppression of anoikis by v-Src but not by activated c-H-ras in human gallbladder epithelial cells.
Suppression of colorectal oncogenesis by selenium-enriched milk proteins: apoptosis and K-ras mutations.
Suppression of Egr-1 transcription through targeting of the serum response factor by oncogenic H-Ras.
Suppression of Erk activation and in vivo growth in esophageal cancer cells by the dominant negative Ras mutant, N116Y.
Suppression of invasion of a hamster pancreatic cancer cell line by antisense oligonucleotides mutation-matched to K-ras gene.
Suppression of non-small cell lung tumor development by the let-7 microRNA family.
Suppression of ras-transformants (review).
Suppression of various human tumor cell lines by a dominant negative H-ras mutant.
Suppressive effect of modified dominant negative RAS mutant on human cancer by gene transfer with non-viral vector.
Surface charge: a key determinant of protein localization and function.
Surgical treatment of hepatocellular carcinoma and related basic research with special reference to recurrence and metastasis.
Survivin depletion preferentially reduces the survival of activated K-Ras-transformed cells.
Sustained inhibition of tumor growth and prolonged survival following sequential administration of doxorubicin and zoledronic acid in a breast cancer model.
Synchronous adenocarcinomas of intestinal type of the inner nose and the colon.
Syndecan-1 and -4 differentially regulate oncogenic K-ras dependent cell invasion into collagen through ?2?1 integrin and MT1-MMP.
Synergism between K-rasVal12 and mutant Apc accelerates murine large intestinal tumourigenesis.
Synergistic effect of MNU and DMBA in mammary carcinogenesis and H-ras activation in female Sprague-Dawley rats.
Synthesis of isomeric 3-piperidinyl and 3-pyrrolidinyl benzo[5,6]cyclohepta[1,2-b]pyridines: sulfonamido derivatives as inhibitors of Ras prenylation.
Synthesis, molecular characterization, and biological activity of novel synthetic derivatives of chromen-4-one in human cancer cells.
Synthetic 8-hydroxydeoxyguanosine inhibited metastasis of pancreatic cancer through concerted inhibitions of ERM and Rho-GTPase.
Synthetic miR-143 Exhibited an Anti-Cancer Effect via the Downregulation of K-RAS Networks of Renal Cell Cancer Cells In Vitro and In Vivo.
Systematic approach identifies RHOA as a potential biomarker therapeutic target for Asian gastric cancer.
Systemic cytotoxic and biological therapies of colorectal liver metastases: expert consensus statement.
Systems-wide analysis of K-Ras, Cdc42, and PAK4 signaling by quantitative phosphoproteomics.
T cell recognition of a point mutation in the P21 Ras protein.
T-RMSD: a fine-grained, structure-based classification method and its application to the functional characterization of TNF receptors.
Targeted deletion of RasGRP1 impairs skin tumorigenesis.
Targeted deletion of the genes encoding NTH1 and NEIL1 DNA N-glycosylases reveals the existence of novel carcinogenic oxidative damage to DNA.
Targeted deletion of the H-ras gene decreases tumor formation in mouse skin carcinogenesis.
Targeted expression of oncogenic K-ras in intestinal epithelium causes spontaneous tumorigenesis in mice.
Targeted Quantitative Proteomics Revealed Arsenite-induced Proteasomal Degradation of RhoB in Fibroblast Cells.
Targeting ?-catenin in hepatocellular cancers induced by coexpression of mutant ?-catenin and K-Ras in mice.
Targeting autophagy addiction in cancer.
Targeting Bcl-2 stability to sensitize cells harboring oncogenic ras.
Targeting Cdc42 in cancer.
Targeting Cdc42 with the anticancer compound MBQ-167 inhibits cell polarity and growth in the budding yeast S. cerevisiae.
Targeting Cdc42 with the small molecule drug AZA197 suppresses primary colon cancer growth and prolongs survival in a preclinical mouse xenograft model by downregulation of PAK1 activity.
Targeting geranylgeranylation reduces adrenal gland tumor burden in a murine model of prostate cancer metastasis.
Targeting heat shock protein 90 with CUDC-305 overcomes erlotinib resistance in non-small cell lung cancer.
Targeting interferon signaling and CTLA-4 enhance the therapeutic efficacy of anti-PD-1 immunotherapy in preclinical model of HPV+ oral cancer.
Targeting K-Ras and apoptosis-driven cellular transformation in cancer.
Targeting Lactate Dehydrogenase-A Inhibits Tumorigenesis and Tumor Progression in Mouse Models of Lung Cancer and Impacts Tumor-Initiating Cells.
Targeting Mutated K-ras in Pancreatic Adenocarcinoma Using an Adjuvant Vaccine.
Targeting NRAS(Q61K) mutant delays tumor growth and angiogenesis in non-small cell lung cancer.
Targeting of Both the c-Met and EGFR Pathways Results in Additive Inhibition of Lung Tumorigenesis in Transgenic Mice.
Targeting oncogenic KRAS in non-small cell lung cancer cells by phenformin inhibits growth and angiogenesis.
Targeting Pancreatic Cancer Metastasis by Inhibition of Vav1, a Driver of Tumor Cell Invasion.
Targeting PI3K Pathway in Pancreatic Ductal Adenocarcinoma: Rationale and Progress.
Targeting plasma membrane phosphatidylserine content to inhibit oncogenic KRAS function.
Targeting protein geranylgeranylation slows tumor development in a murine model of prostate cancer metastasis.
Targeting Rac and Cdc42 GEFs in Metastatic Cancer.
Targeting Rac and Cdc42 GTPases in Cancer.
Targeting Rho GTPase signaling for cancer therapy.
Targeting Rho GTPase Signaling Networks in Cancer.
Targeting RNA helicase DHX33 blocks Ras-driven lung tumorigenesis in vivo.
Targeting the ?4-?5 dimerization interface of K-RAS inhibits tumor formation in vivo.
Targeting the K-Ras--JNK axis eliminates cancer stem-like cells and prevents pancreatic tumor formation.
Targeting the mevalonate cascade as a new therapeutic approach in heart disease, cancer and pulmonary disease.
Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer.
Targeting the Ras-ERK pathway in pancreatic adenocarcinoma.
Targeting the Wnt Pathway and Cancer Stem Cells with Anti-progastrin Humanized Antibodies as a Potential Treatment for K-RAS-Mutated Colorectal Cancer.
Targeting thioredoxin reductase 1 reduction in cancer cells inhibits self-sufficient growth and DNA replication.
Targeting TRAF3IP2, Compared to Rab27, is More Effective in Suppressing the Development and Metastasis of Breast Cancer.
Telomerase activity and Bcl-2 expression in gallbladders of pancreaticobiliary maljunction patients: a preliminary study.
Telomerase activity and its clinicopathological significance in gastric cancer.
Temporal changes in the mutant frequency and mutation spectra of the 61st codon of the H-ras oncogene following exposure of B6C3F1 mice to N-nitrosodiethylamine (DEN).
TGF-? acts as a dual regulator of COX-2/PGE2 tumor promotion depending of its cross-interaction with H-Ras and Wnt/?-catenin pathways in colorectal cancer cells.
TGF-?1-induced cell migration in pancreatic carcinoma cells is RAC1 and NOX4-dependent and requires RAC1 and NOX4-dependent activation of p38 MAPK.
The Accumulation of Multiple Genetic Abnormalities in Individual Tumor Cells in Human Breast Cancers: Clinical Prognostic Implications
The added value of molecular testing in small pancreatic cysts.
The amplification of c-erb-B2 in cancer-free surgical margins is a predictor of poor outcome in oral squamous cell carcinoma.
The anticancer phytochemical rocaglamide inhibits Rho GTPase activity and cancer cell migration.
The association between a mutated ras gene and cyclooxygenase-2 expression in human breast cancer cell lines.
The Association Between Selected Risk Factors for Pancreatic Cancer and the Expression of p53 and K-ras Codon 12 Mutations.
The association of K-ras gene mutation and vascular endothelial growth factor gene expression in pancreatic carcinoma.
The association of the H-ras oncogene and steroid hormone receptors in gynecological cancer.
The balanced induction of K-ras codon 12 and 13 mutations in mucosa differs from their ratio in neoplastic tissues.
The bisphosphonate zoledronic acid decreases tumor growth in bone in mice with defective osteoclasts.
The bisphosphonate zoledronic acid has antimyeloma activity in vivo by inhibition of protein prenylation.
The blood-testis barrier and its implications for male contraception.
The brain microenvironment negatively regulates miRNA-768-3p to promote K-ras expression and lung cancer metastasis.
The c-K-ras gene and human cancer (review).
The calcium sensing receptor (CaSR) promotes Rab27B expression and activity to control secretion in breast cancer cells.
The caM kinase, Pnck, is spatially and temporally regulated during murine mammary gland development and may identify an epithelial cell subtype involved in breast cancer.
The Cdc42 Effector Kinase PAK4 Localizes to Cell-Cell Junctions and Contributes to Establishing Cell Polarity.
The CDC42-specific inhibitor derived from ACK-1 blocks v-Ha-Ras-induced transformation.
The cellular and molecular pathogenesis of colorectal cancer.
The clinicopathological significance of K-RAS point mutation and gene amplification in endometrial cancer.
The combination of everolimus and zoledronic acid increase the efficacy of gemcitabine in a mouse model of pancreatic adenocarcinoma.
The cornerstone K-RAS mutation in pancreatic adenocarcinoma: From cell signaling network, target genes, biological processes to therapeutic targeting.
The differential effects of wildtype and mutated K-Ras on MST2 signalling are determined by K-Ras activation kinetics.
The differentially mutational spectra of the APC, K-ras, and p53 genes in sporadic colorectal cancers from Taiwanese patients.
The discovery and maturation of peptide biologics targeting the small G-protein Cdc42: A bioblockade for Ras-driven signaling.
The drs tumor suppressor regulates glucose metabolism via lactate dehydrogenase-B.
The dual functions of Rab11 and Rab35 GTPases-regulation of cell division and promotion of tumorigenicity.
The Dual Role of Macropinocytosis in Cancers: Promoting Growth and Inducing Methuosis to Participate in Anticancer Therapies as Targets.
The dynamic nature of the K-Ras/calmodulin complex can be altered by oncogenic mutations.
The dynamics of Rho GTPase signaling and implications for targeting cancer and the tumor microenvironment.
The effect of forced expression of mutated K-RAS gene on gastrointestinal cancer cell lines and the IGF-1R targeting therapy.
The effect of gefitinib on B-RAF mutant non-small cell lung cancer and transfectants.
The effects of a binary mixture of benzo(a)pyrene and 7H-dibenzo(c,g)carbazole on lung tumors and K-ras oncogene mutations in strain A/J mice.
The effects of cigarette smoking extracts on cell cycle and tumor spread: novel evidence.
The effects of phytoestrogens on human pancreatic tumor cells in vitro.
The Emerging Role of the RAB25 Small GTPase in Cancer.
The evolving role of monoclonal antibodies in colorectal cancer: early presumptions and impact on clinical trial development.
The exocyst complex binds the small GTPase RalA to mediate filopodia formation.
The farnesyl transferase inhibitor RPR-130401 does not alter radiation susceptibility in human tumor cells with a K-Ras mutation in spite of large changes in ploidy and lamin B distribution.
The farnesyl transferase inhibitor SCH 66336 induces a G(2) --> M or G(1) pause in sensitive human tumor cell lines.
The farnesyltransferase inhibitor FTI-277 radiosensitizes H-ras-transformed rat embryo fibroblasts.
The farnesyltransferase inhibitor L744,832 reduces hypoxia in tumors expressing activated H-ras.
The frequency of p53, K-ras mutations, and microsatellite instability differs in uterine endometrioid and serous carcinoma: evidence of distinct molecular genetic pathways.
The Function of RAS Mutation in Cancer and Advances in its Drug Research.
The future of surgery for pancreatic cancer.
The genetics of pancreatic cancer.
The growth and tumor suppressor novel ras effector 1A (NORE1A) is a regulatory node between ras signaling and microtubule nucleation.
The guanine triphosphatase (GTPase) activating protein (GAP)-related domain of the neurofibromatosis type 1 gene is not mutated in neural crest-derived sporadic tumours.
The H-ras oncogene product p21 and prognosis in human breast cancer.
The H-ras oncogene regulates expression of 70- and 45-kDa cell-surface molecules whose expression correlates with tumor-cell immunogenicity.
The hamster model of sequential oral oncogenesis.
The Human Minor Histocompatibility Antigen1 Is a RhoGAP.
The Importance of Ras in Drug Resistance in Cancer.
The incidence of port-site metastases might be reduced.
The inhibitory effect of salinomycin on the proliferation, migration and invasion of human endometrial cancer stem-like cells.
The interaction of IQGAP1 with the exocyst complex is required for tumor cell invasion downstream of Cdc42 and RhoA.
The K-Ras 4A isoform promotes apoptosis but does not affect either lifespan or spontaneous tumor incidence in aging mice.
The K-Ras effector p38? MAPK confers intrinsic resistance to tyrosine kinase inhibitors by stimulating EGFR transcription and EGFR dephosphorylation.
The K-ras gene regulates vascular endothelial growth factor gene expression in non-small cell lung cancers.
The Kinase Mirk/dyrk1B: A Possible Therapeutic Target in Pancreatic Cancer.
The let-7 microRNA reduces tumor growth in mouse models of lung cancer.
The let-7a microRNA protects from growth of lung carcinoma by suppression of k-Ras and c-Myc in nude mice.
The level of oncogene H-Ras correlates with tumorigenicity and malignancy.
The malignant capacity of skin tumours induced by expression of a mutant H-ras transgene depends on the cell type targeted.
The mammalian ribonucleotide reductase R2 component cooperates with a variety of oncogenes in mechanisms of cellular transformation.
The merlin interacting proteins reveal multiple targets for NF2 therapy.
The metastasis-associated gene CD24 is regulated by Ral GTPase and is a mediator of cell proliferation and survival in human cancer.
The microdomain-organizing protein MPP1 is required for insulin-stimulated activation of H-Ras.
The miR-18a* microRNA functions as a potential tumor suppressor by targeting on K-Ras.
The MLK-related Kinase (MRK) Is a Novel RhoC Effector That Mediates Lysophosphatidic Acid (LPA)-stimulated Tumor Cell Invasion.
The molecular basis of ovarian cancer.
The mTOR pathway and its role in human genetic diseases.
The mucin MUC4 is a transcriptional and post-transcriptional target of K-ras oncogene in pancreatic cancer. Implication of MAPK/AP-1, NF-?B and RalB signaling pathways.
The mutations of the EGFR and K-ras genes in resected stage I lung adenocarcinoma and their clinical significance.
The National Toxicology Program evaluation of genetically altered mice as predictive models for identifying carcinogens.
The noncoding RNAs SNORD50A and SNORD50B bind K-Ras and are recurrently deleted in human cancer.
The novel exon 11 mutation of BRCA1 gene in a high-risk family.
The oncogenic mutation in the pleckstrin homology domain of AKT1 in endometrial carcinomas.
The p53 tumor-suppressor gene and ras oncogene mutations in oral squamous-cell carcinoma.
The pattern of K-ras mutation in pulmonary adenocarcinoma defines a new pathway of tumour development in the human lung.
The Pivotal Roles of the Epithelial Membrane Protein Family in Cancer Invasiveness and Metastasis.
The potential diagnostic use of K-ras codon 12 and p53 alterations in brush cytology from the pancreatic head region.
The presence of K-12 ras mutations in duodenal adenocarcinomas and the absence of ras mutations in other small bowel adenocarcinomas and carcinoid tumors.
The pro-apoptotic K-Ras 4A proto-oncoprotein does not affect tumorigenesis in the ApcMin/+ mouse small intestine.
The prognostic impact of RAP2A expression in patients with early and locoregionally advanced nasopharyngeal carcinoma in an endemic area.
The prognostic significance of K-ras, p53, and APC mutations in colorectal carcinoma.
The prognostic significance of p63 cytoplasmic expression in colorectal cancer. An immunohistochemical study.
The prognostic significance of tumor-associated markers p53, HER-2/neu, c-myc, v-H-ras, PCNA and EGFr of local and distant recurrence in localized human prostatic adenocarcinoma.
The proliferation of multiple myeloma colonies (MY-CFUc) in vitro is independent of prognosis and is not associated with mutated N- or K-ras alleles in human bone marrow aspirates.
The R-enantiomer of ketorolac reduces ovarian cancer tumor burden in vivo.
The RAB25 small GTPase determines aggressiveness of ovarian and breast cancers.
The Rab2A GTPase promotes breast cancer stem cells and tumorigenesis via Erk signaling activation.
The rac activator Tiam1 is a Wnt-responsive gene that modifies intestinal tumor development.
The Rac GTPase in cancer: from old concepts to new paradigms.
The Rac1 splice form Rac1b promotes K-ras-induced lung tumorigenesis.
The Ral/exocyst effector complex counters c-Jun N-terminal kinase-dependent apoptosis in Drosophila melanogaster.
The Ras Effector RASSF2 Controls the PAR-4 Tumor Suppressor.
The ras gene family in human non-small-cell lung cancer.
The ras oncogenes in human lung cancer.
The RAS subfamily Evolution - tracing evolution for its utmost exploitation.
The Ras-membrane Interface: Isoform-specific Differences in the Catalytic Domain.
The RAS-RAL axis in cancer: evidence for mutation-specific selectivity in non-small cell lung cancer.
The Ras-related protein, Rap1A, mediates thrombin-stimulated, integrin-dependent glioblastoma cell proliferation and tumor growth.
The RASSF1A Tumor Suppressor Activates Bax via MOAP-1.
The RASSF1A tumor suppressor.
The Rb-E2F transcriptional regulatory pathway in tumor angiogenesis and metastasis.
The relationship between 1,2-dimethylhydrazine dose and the induction of colon tumours: tumour development in female SWR mice does not require a K-ras mutational event.
The renaissance of Ras.
The retinoblastoma gene Rb and its family member p130 suppress lung adenocarcinoma induced by oncogenic K-Ras.
The RHO Family GTPases: Mechanisms of Regulation and Signaling.
The Rho GTPase Cdc42 is required for primary mammary epithelial cell morphogenesis in vitro.
The Rho GTPase Rac1 is required for recycling endosome-mediated secretion of TNF in macrophages.
The Rho GTPase RhoB regulates cadherin expression and epithelial cell-cell interaction.
The Rho GTPase RhoE is a p53-regulated candidate tumor suppressor in cancer cells.
The Rho GTPase signalling pathway in urothelial carcinoma.
The role of ARHGAP9: clinical implication and potential function in acute myeloid leukemia.
The role of BUB and CDC proteins in low-grade breast cancers.
The role of circulating tumor cells and K-ras mutations in patients with locally advanced rectal cancer: a prospective study.
The role of Dlc1 isoform 2 in K-Ras2(G12D) induced thymic cancer.
The role of DNA hypermethylation in human neoplasia.
The role of glycometabolic plasticity in cancer.
The role of human papillomavirus 16 E6 in anchorage-independent and invasive growth of mouse tonsil epithelium.
The role of hyperplastic nodules in dichloroacetic acid-induced hepatocarcinogenesis in B6C3F1 male mice.
The role of induction (neoadjuvant) chemotherapy in stage IIIA NSCLC.
The role of K-Ras gene mutation in TRAIL-induced apoptosis in pancreatic and lung cancer cell lines.
The role of miRNAs targeting K-ras and APC genes in colorectal cancer.
The role of molecular analysis in the diagnosis and surveillance of pancreatic cystic neoplasms.
The role of p19 and p21 H-Ras proteins and mutants in miRNA expression in cancer and a Costello syndrome cell model.
The role of p21ras in pancreatic neoplasia and chronic pancreatitis.
The role of pancreatic cyst fluid molecular analysis in predicting cyst pathology.
The role of pharmacogenetics in adjuvant treatment of non-small cell lung cancer.
The role of PP2A A subunits in tumor suppression.
The role of profilin complexes in cell motility and other cellular processes.
The role of Ral A in epidermal growth factor receptor-regulated cell motility.
The role of ras gene mutation in gastric cancer and precancerous lesions.
The Role of Ras-Associated Protein 1 (Rap1) in Cancer: Bad Actor or Good Player?
The role of Rho GTPases in disease development.
The role of Rho GTPases' substrates Rac and Cdc42 in osteoclastogenesis and relevant natural medicinal products study.
The role of sema4D in vasculogenic mimicry formation in non-small cell lung cancer and the underlying mechanisms.
The role of TGF-? and its crosstalk with RAC1/RAC1b signaling in breast and pancreas carcinoma.
The role of the H-ras oncogene in radiation resistance and metastasis.
The role of the oncogenic Rab35 in cancer invasion, metastasis, and immune evasion, especially in leukemia.
The role of the small GTPase Rab31 in cancer.
The roles of Cdc42 and Rac1 in the formation of plasma membrane protrusions in cancer epithelial HeLa cells.
The second intron of the K-ras gene contains regulatory elements associated with mouse lung tumor susceptibility.
The secretory small GTPase Rab27B as a marker for breast cancer progression.
The small GTPase ARF6 regulates protein trafficking to control cellular function during development and in disease.
The small GTPase Rac1 is involved in the maintenance of stemness and malignancies in glioma stem-like cells.
The small GTPase Rac1 links the Kaposi sarcoma-associated herpesvirus vGPCR to cytokine secretion and paracrine neoplasia.
The small GTPase RAC3 gene is located within chromosome band 17q25.3 outside and telomeric of a region commonly deleted in breast and ovarian tumours.
The Small GTPase Ral orchestrates MVB biogenesis and exosome secretion.
The small GTPase RhoA regulates the expression and function of the sodium channel Nav1.5 in breast cancer cells.
The small GTPases K-Ras, N-Ras, and H-Ras have distinct biochemical properties determined by allosteric effects.
The structure and function of the H-ras proto-oncogene are not altered in rat liver tumors initiated by 2-acetylaminofluorene, 2-acetylaminophenanthrene and trans-4-acetylaminostilbene.
The suppressor of metastasis Nm23-H1 interacts with the Cdc42 Rho family member and the pleckstrin homology domain of oncoprotein Dbl-1 to suppress cell migration.
The TGF-{beta} co-receptor endoglin modulates the expression and transforming potential of H-Ras.
The transforming and suppressor functions of p53 alleles: effects of mutations that disrupt phosphorylation, oligomerization and nuclear translocation.
The trihelical bundle subdomain of the GGA proteins interacts with multiple partners through overlapping but distinct sites.
The tumor suppressor DiRas3 forms a complex with H-Ras and C-RAF proteins and regulates localization, dimerization, and kinase activity of C-RAF.
The tumor suppressor LKB1 regulates lung cancer cell polarity by mediating cdc42 recruitment and activity.
The tumor suppressor protein DLC1 is regulated by PKD-mediated GAP domain phosphorylation.
The tumor suppressor RASSF1A is a novel effector of small G protein Rap1A.
The tumour suppressor DLC2 ensures mitotic fidelity by coordinating spindle positioning and cell-cell adhesion.
The type III TGF-{beta} receptor regulates epithelial and cancer cell migration through {beta}-arrestin2-mediated activation of Cdc42.
The type III TGFbeta receptor regulates directional migration: new tricks for an old dog.
The type of K-ras mutation determines prognosis in colorectal cancer.
The type III TGF? receptor regulates filopodia formation via a Cdc42-mediated IRSp53-N-WASP interaction in epithelial cells.
The V-ATPase-inhibitor Archazolid abrogates tumor metastasis via inhibition of endocytic activation of the Rho-GTPase Rac1.
The v-mos and H-ras oncogene expression represses glucocorticoid hormone-dependent transcription from the mouse mammary tumor virus LTR.
The VEGF/Rho GTPase signalling pathway: A promising target for anti-angiogenic/anti-invasion therapy.
The ZNF750-RAC1 axis as potential prognostic factor for breast cancer.
Therapeutic Effect of Y-27632 on Tumorigenesis and Cisplatin-Induced Peripheral Sensory Loss through RhoA-NF-?B.
Therapeutic efficacy of an adenovirus-mediated anti-H-ras ribozyme in experimental bladder cancer.
Therapeutic targeting of human hepatocyte growth factor with a single neutralizing monoclonal antibody reduces lung tumorigenesis.
Three-dimensional culture of a mixed mullerian tumor of the ovary: expression of in vivo characteristics.
Thyroid hemiagenesis, Graves' disease and differentiated thyroid cancer: a very rare association: case report and review of literature.
Time-dependent biological differences in molecular markers of high-grade urothelial cancer over 7 decades (ras proteins, pTEN, uPAR, PAI-1 and MMP-9).
Time-serial Assessment of Drug Combination Interventions in a Mouse Model of Colorectal Carcinogenesis Using Optical Coherence Tomography.
Tissue and serum biomarkers as prognostic variables in endometrioid-type endometrial cancer.
Tissue Factor and Cancer Stem Cells. Is There a Linkage?
Tissue factor expression in non-small cell lung cancer: relationship with vascular endothelial growth factor expression, microvascular density, and K-ras mutation.
Tissue sampling for mutation analysis in colorectal cancer: K-ras is homogeneously distributed throughout the tumor tissue.
Tissue-specific expression of the K-ras allele from the A/J parent in (A/J x TSG-p53) F1 mice.
TNF-?/NF-?B signaling epigenetically represses PSD4 transcription to promote alcohol-related hepatocellular carcinoma progression.
TNMF versus TNM in staging of colorectal cancer.
Tobacco smoke promotes lung tumorigenesis by triggering IKKbeta- and JNK1-dependent inflammation.
Tobacco smoke-induced lung tumorigenesis in mutant A/J mice with alterations in K-ras, p53, or Ink4a/Arf.
Tools to study the function of the Ras-related, estrogen-regulated growth inhibitor in breast cancer.
Topological and quantitative-analyses of early events in tumor-formation using histochemically-tagged transformed 3t3 cells.
Total alkaloids of
Toward optimized front-line therapeutic strategies in patients with metastatic colorectal cancer--an expert review from the International Congress on Anti-Cancer Treatment (ICACT) 2009.
TP53 and RAS mutations in metachronous tumors from patients with cancer of the upper aerodigestive tract.
Traditional Chinese medicine Jianpi Bushen therapy suppresses the onset of pre-metastatic niche in a murine model of spontaneous lung metastasis.
Tranilast inhibits the expression of genes related to epithelial-mesenchymal transition and angiogenesis in neurofibromin-deficient cells.
Transcription regulation by histone deacetylases.
Transcriptional activation of H- and N-ras oncogenes in human cervical cancer.
Transcriptional activation of H-ras, K-ras and N-ras proto-oncogenes in human bladder tumors.
Transcriptional control of the human high mobility group A1 gene: basal and oncogenic Ras-regulated expression.
Transcriptional regulation of the c-H-ras1 gene by the P53 protein is implicated in the development of human endometrial and ovarian tumours.
Transcriptional signatures of Ral GTPase are associated with aggressive clinicopathologic characteristics in human cancer.
Transcriptional switching model for the regulation of tumorigenesis and metastasis by the ha-ras oncogene - transcriptional changes in the ha-ras tumor-suppressor gene lysyl oxidase.
Transfection of K-rasAsp12 cDNA markedly elevates IL-1beta- and lipopolysaccharide-mediated inducible nitric oxide synthase expression in rat intestinal epithelial cells.
Transformation of Epstein-Barr virus immortalized human B-cells by chemical carcinogens.
Transformation of hamster pancreatic duct cells by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), in vitro.
Transformation of human and murine fibroblasts without viral oncoproteins.
Transformation of human osteoblast cells to the tumorigenic phenotype by depleted uranium-uranyl chloride.
Transformation of mouse skin endothelial cells in vivo by direct application of plasmid DNA encoding the human T24 H-ras oncogene.
Transforming growth factor beta expression and transformation of rat lung epithelial cells by crystalline silica (quartz).
Transforming growth factor-beta1 modulates metalloproteinase-2 and -9, nitric oxide, RhoA and alpha-smooth muscle actin expression in colon adenocarcinoma cells.
Transgenic mice provide genetic evidence that transforming growth factor alpha promotes skin tumorigenesis via H-ras-dependent and H-ras-independent pathways.
Transglutaminase-2, RNA-binding proteins and mitochondrial proteins selectively traffic to MDCK cell-derived microvesicles following H-Ras-induced epithelial-mesenchymal transition.
Transient depletion of p53 followed by transduction of c-Myc and K-Ras converts ovarian stem-like cells into tumor-initiating cells.
Transient Exposure of Mammary Tumors to PD184352 and UCN-01 Causes Tumor Cell Death In Vivo and Prolonged Suppression of Tumor Regrowth.
Transition from squamous cell carcinoma to adenocarcinoma in adenosquamous carcinoma of the lung.
Translating discovery in zebrafish pancreatic development to human pancreatic cancer: biomarkers, targets, pathogenesis, and therapeutics.
Transplacental arsenic plus postnatal 12-O-teradecanoyl phorbol-13-acetate exposures associated with hepatocarcinogenesis induce similar aberrant gene expression patterns in male and female mouse liver.
Transplacental mutagenicity of cisplatin: H-ras codon 12 and 13 mutations in skin tumors of SENCAR mice.
Trisomy 12 correlates with elevated expression of p21 ras in a human adenosquamous carcinoma of the lung.
TUCR.454 inhabits metastasis in lung cancer cells.
Tumor and host factors that may limit efficacy of chemotherapy in non-small cell and small cell lung cancer.
Tumor angiogenesis in chronic pancreatitis and pancreatic adenocarcinoma: impact of K-ras mutations.
Tumor budding predicts response to anti-EGFR therapies in metastatic colorectal cancer patients.
Tumor cell dependence on Ran-GTP-directed mitosis.
Tumor endothelial marker 5 expression in endothelial cells during capillary morphogenesis is induced by the small GTPase Rac and mediates contact inhibition of cell proliferation.
Tumor gene mutations and messenger RNA expression: correlation with clinical response to icotinib hydrochloride in non-small cell lung cancer.
Tumor induction by an endogenous K-ras oncogene is highly dependent on cellular context.
Tumor initiating cells in pancreatic cancer: A critical view.
Tumor location and detection of k-ras mutations in stool from colorectal cancer patients.
Tumor markers in colorectal cancer, gastric cancer and gastrointestinal stromal cancers: European group on tumor markers 2014 guidelines update.
Tumor metastasis suppressor nm23H1 regulates Rac1 GTPase by interaction with Tiam1.
Tumor multiplicity, DNA adducts and K-ras mutation pattern of 5-methylchrysene in strain A/J mouse lung.
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) induces chemotactic migration of monocytes via a death receptor 4-mediated RhoGTPase pathway.
Tumor necrosis factor alpha stimulation of Rac1 activity. Role of isoprenylcysteine carboxylmethyltransferase.
Tumor necrosis factor links chronic obstructive pulmonary disease and K-ras mutant lung cancer through induction of an immunosuppressive pro-tumor microenvironment.
Tumor progression of skin carcinoma cells in vivo promoted by clonal selection, mutagenesis, and autocrine growth regulation by granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor.
Tumor Protein p53 and K-ras Gene Mutations in Peruvian Patients with Gallbladder Cancer
Tumor regression grades, K-RAS mutational profile and c-MET in colorectal liver metastases.
Tumor rejection antigens on BALB3T3 cells transformed by activated oncogenes.
Tumor suppression by p27Kip1 and p21Cip1 during chemically induced skin carcinogenesis.
Tumor Suppressive Role of ARHGAP17 in Colon Cancer Through Wnt/?-Catenin Signaling.
Tumor suppressive role of miR-33a-5p in pancreatic ductal adenocarcinoma cells by directly targeting RAP2A.
Tumor suppressor p16INK4a controls oncogenic K-Ras function in human pancreatic cancer cells.
Tumor suppressors miR-143 and miR-145 and predicted target proteins API5, ERK5, K-RAS, and IRS-1 are differentially expressed in proximal and distal colon.
Tumor-suppressive pathways in pancreatic carcinoma.
Tumorigenesis in colorectal tumors from patients with hereditary non-polyposis colorectal cancer.
Tumorigenic activity and therapeutic inhibition of Rheb GTPase.
Tumorigenic conversion of primary human esophageal epithelial cells using oncogene combinations in the absence of exogenous Ras.
Tumorigenic transformation of spontaneously immortalized fibroblasts from patients with a familial cancer syndrome.
Tumorigenicity of acrylamide and its metabolite glycidamide in the neonatal mouse bioassay.
Tumorigenicity of nitropolycyclic aromatic hydrocarbons in the neonatal B6C3F1 mouse bioassay and characterization of ras mutations in liver tumors from treated mice.
Tumors induced in mice by direct inoculation of plasmid DNA expressing both activated H-ras and c-myc.
Tumors of the pancreas with osteoclast-like and pleomorphic giant cells: an immunohistochemical and ploidy study.
Tumour cell CD99 regulates transendothelial migration via CDC42 and actin remodelling.
Tumour-derived exosomes: Tiny envelopes for big stories.
Tumour-derived mutated K-ras codon 12 expression in regional lymph nodes of stage II colorectal cancer patients is not associated with increased risk of cancer-related death.
Twenty Novel Disease Group-Specific and 12 New Shared Macrophage Pathways in Eight Groups of 34 Diseases Including 24 Inflammatory Organ Diseases and 10 Types of Tumors.
Twists and turns of invasion.
Two novel H-RAS mutations identified in a child with an atypical spitzoid tumor.
Type of TP53 mutation influences oncogenic potential and spectrum of associated K-ras mutations in lung-specific transgenic mice.
Tyrosyl phosphorylation of KRAS stalls GTPase cycle via alteration of switch I and II conformation.
Ubc9 promotes breast cell invasion and metastasis in a sumoylation-independent manner.
Ubiquitin-dependent regulation of Cdc42 by XIAP.
Ultraviolet B irradiation induces expansion of intraepithelial tumor cells in a tissue model of early cancer progression.
Understanding the Complexity of the Tumor Microenvironment in K-ras Mutant Lung Cancer: Finding an Alternative Path to Prevention and Treatment.
Understanding the predictive role of K-ras for epidermal growth factor receptor-targeted therapies in colorectal cancer.
Unique K-ras mutational pattern in pancreatic adenocarcinoma from Taiwanese patients.
Up-regulation of vascular endothelial growth factor/vascular permeability factor in mouse skin carcinogenesis correlates with malignant progression state and activated H-ras expression levels.
Update on the molecular profile of the MDA-MB-453 cell line as a model for apocrine breast carcinoma studies.
Upregulated expression of ROCK1 promotes cell proliferation by functioning as a target of miR-335-5p in non-small cell lung cancer.
Upregulated miRNA-622 inhibited cell proliferation, motility, and invasion via repressing Kirsten rat sarcoma in glioblastoma.
Upregulation of miR-582-5p inhibits cell proliferation, cell cycle progression and invasion by targeting Rab27a in human colorectal carcinoma.
Upregulation of non-mutated H-ras and its upstream and downstream signaling proteins in colorectal cancer.
Upregulation of ROCK2 in gastric cancer cell promotes tumor cell proliferation, metastasis and invasion.
Use of avian retroviral vectors to introduce transcriptional regulators into mammalian cells for analyses of tumor maintenance.
Use of E mu-PIM-1 transgenic mice short-term in vivo carcinogenicity testing: lymphoma induction by benzo[a]pyrene, but not by TPA.
Use of K-Ras as a predictive biomarker for selecting anti-EGF receptor/pathway treatment.
Use of microsatellite marker loss of heterozygosity in accurate diagnosis of pancreaticobiliary malignancy from brush cytology samples.
Use of molecular markers for predicting therapy response in cancer patients.
Use of p53 transgenic mice in the development of cancer models for multiple purposes.
Use of ras-transformed human ovarian surface epithelial cells as a model for studying ovarian cancer.
Use of retrovirus expression of interfering RNA to determine the contribution of activated k-ras and ras effector expression to human tumor cell growth.
Use of spontaneous Epstein-Barr virus-lymphoblastoid cell lines genetically modified to express tumor antigen as cancer vaccines: mutated p21 ras oncogene in pancreatic carcinoma as a model.
Usefulness of analysis of p53 alteration and observation of surface microstructure for diagnosis of ulcerative colitis-associated colorectal neoplasia.
Usefulness of K-ras gene mutation at codon 12 in bile for diagnosing biliary strictures.
Usufuleness of p16 and K-ras mutation in pancreatic adenocarcinoma and chronic pancreatitis differential diagnosis.
Utilization of K-ras mutations identified in stool DNA for the early detection of colorectal cancer.
Vaccination against RhoC induces long-lasting immune responses in patients with prostate cancer: results from a phase I/II clinical trial.
Vaccination with Clostridium perfringens recombinant proteins in combination with Montanide™ ISA 71 VG adjuvant increases protection against experimental necrotic enteritis in commercial broiler chickens.
Vaccination with mutant ras peptides and induction of T-cell responsiveness in pancreatic carcinoma patients carrying the corresponding RAS mutation.
Validation of blood testing for K-ras mutations in colorectal and pancreatic cancer.
Values of mutations of K-ras oncogene at codon 12 in detection of pancreatic cancer: 15-year experience.
VAMP8, a vesicle-SNARE required for RAB37-mediated exocytosis, possesses a tumor metastasis suppressor function.
Variable apoptotic response of NSCLC cells to inhibition of the MEK/ERK pathway by small molecules or dominant negative mutants.
Variant mutational activation of the K-ras oncogene in renal mesenchymal tumors induced in newborn F344 rats by methyl(methoxymethyl)nitrosamine.
Variegated RHOA mutations in human cancers.
Variously substituted (phosphonoacetamido)oxy analogues of geranylgeranyl diphosphate (GGdP) as GGdP-transferase (GGTase) inhibitors and antiproliferative agents.
Vascular endothelial growth factor and nitric oxide synthase expression in human lung cancer and the relation to p53.
Vascular RhoJ is an effective and selective target for tumor angiogenesis and vascular disruption.
Vasodilator-stimulated phosphoprotein promotes activation of hepatic stellate cells by regulating Rab11-dependent plasma membrane targeting of transforming growth factor beta receptors.
VEGF neutralizing aerosol therapy in primary pulmonary adenocarcinoma with K-ras activating-mutations.
Versatile Role of Rab27a in Glioma: Effects on Release of Extracellular Vesicles, Cell Viability, and Tumor Progression.
Vitamin E and cancer prevention: recent advances and future potentials.
Well-differentiated papillary mesothelioma of the peritoneum is genetically defined by mutually exclusive mutations in TRAF7 and CDC42.
Wild-type H- and N-Ras promote mutant K-Ras-driven tumorigenesis by modulating the DNA damage response.
Wild-type K-ras has a tumour suppressor effect on carcinogen-induced murine colorectal adenoma formation.
Wild-Type N-Ras, Overexpressed in Basal-like Breast Cancer, Promotes Tumor Formation by Inducing IL-8 Secretion via JAK2 Activation.
Wrch-1, a novel member of the Rho gene family that is regulated by Wnt-1.
YAP1 takes over when oncogenic K-Ras slumbers.
ZEB1 drives prometastatic actin cytoskeletal remodeling by downregulating miR-34a expression.
ZIP4 Promotes Muscle Wasting and Cachexia in Mice With Orthotopic Pancreatic Tumors by Stimulating RAB27B-Regulated Release of Extracellular Vesicles From Cancer Cells.
["Field cancerization"--an additional phenomenon in development of colon tumors? K-ras codon 12 mutations in normal colonic mucosa of patients with colorectal neoplasms]
[A case of anal fistula cancer probably developing from intraluminal dissemination of rectal cancer]
[A Case of Rectal Cancer with Unresectable Liver Metastasis Responding to Rechallenge with FOLFIRI].
[A case of synchronous cancer of the gall bladder, common bile duct, and the papilla of vater].
[A case of unresectable multiple hepatic metastases from ascending colon cancer successfully treated with panitumumab and FOLFIRI(5-FU/LV/irinotecan)therapy].
[A resected case of metastatic pancreatic cancer from cecal carcinoma]
[A study on the role of DNA repair gene O6-methylguanine-DNA methyltransferase in the development of human lung cancer]
[Actinic keratoses : Pathogenesis, clinical aspect and modern therapeutic options].
[Advance in the biology of pancreatic of cancer].
[Agreement between information supplied by the patient and a family member on medical history, consumption of tobacco, alcohol and coffee and diet in cancer of the exocrine pancreas and extrahepatic biliary tract]
[Alterations of c-Myc and c-erbB-2 genes in ovarian tumours]
[Altered Treg and IL-1A Expression in the Immune Microenvironment ?of Lung Squamous-cell Cancer after EGFR Blockade].
[Analysis of K-ras, BRCA1/2, CHEK2 mutations and microsatellite markers (loss of heterozygosity at 9p, 17p and 18q) in sporadic pancreas adenocarcinomas]
[Anatomopathological tools for screening and medical surveillance of people exposed to asbestos]
[Anti-pancreatic cancer immune response induced by K-ras mutated peptide]
[Basic studies on mutation analysis of K-ras codon 12 by use of three-dimensional microarray system]
[Biological markers and exposure to asbestos]
[Characteristics of plasma DNA and its application for detection of K-ras gene mutation]
[Clinical analysis of 12 cases of acute myeloid leukemia complicated with synchronous primary solid tumor].
[Clinical significance of transrectal ultrasound in detecting of rectal cancer margin and deciding of distal surgical incisal edge]
[Clinicopathological characteristics, MSI and K-ras gene mutations of double primary malignancies associated with colorectal cancer].
[Colorectal carcinogenesis: a historical review]
[Colorectal carcinoma--molecular markers in clinical routine]
[Correlation between the presence of Kras mutation and the presence of the proteins epiregulin and amphiregulin in colon cancer tissue].
[Correlation of expression of p120ctn , RhoA and Cdc42 and their significance in non-small cell lung cancer.]
[Cytomolecular aspects of colorectal carcinoma]
[Detection of genetic mutations in clinical specimens from cancer patients: comparison of NIRCA and SSCP scanning methods]
[Detection of H-ras and K-ras in tumors of gastrointestinal-pancreatic system]
[Detection of K-ras gene mutations in DNA extracted from the plasma of patients with pancreatic cancer]
[Detection of K-ras mutations in colon cancer by PHA-PHFA (preferential homoduplex formation assay)]
[Detection of K-ras oncogene activation in human lung cancer and its possible clinical application]
[Detection of K-ras point mutations in the stool of patients with colorectal tumors]
[Detection of micrometastases after curative resection for ductal adenocarcinoma of the pancreas]
[Detection of P53 and K-ras gene mutations in lung cancer with oligonucleotide chip]
[Detection of point mutation of Kirsten ras oncogene in pancreatic carcinoma by polymerase chain reaction]
[Detection of ras gene mutations of pancreatic tumors by polymerase chain reaction and direct sequencing method]
[Developing a hospital-based high risk scoring model and screening strategy for pancreatic cancer]
[Diagnosis of colorectal cancer from DNA level]
[Diagnosis of papilloma viruses in cervical cancer in 414 women from Wielkopolska region by the immunohistochemical assessment]
[Effect of blocking of ROCK-1, an effector of small G protein Rho, on the malignant behavior of ovarian tumor cells in vitro]
[Effect of Cdc42 gene inhibited on proliferation, migration and invasion in human hepatocellular carcinoma cells].
[Effect of d-limonene, Salvia miltiorrhiza and turmeric derivatives on membrane association of Ras gene product and gap junction intercellular communication]
[Effect of p38MAPK gene silencing on expression of oncogenes and apoptotic genes induced by PM(2.5) in hepatocytes].
[Effects of tetrahydrobiopterin on the angiogenesis in hepatocellular carcinoma].
[EGFR tyrosine kinase inhibitors as a targeted therapy for bronchioloalveolar carcinoma of the lung: a case report of a clinically prompt and intensive response and literature review]
[Establishment and its biological characteristics of patient-derived lung cancer xenograft models]
[Evaluation of prognostic factors in gynecological cancer examined by molecular biological study]
[Evolution of aneuploidy from diploid colorectal carcinoma as revealed by the analyses of ploidy heterogeneity and Ras mutation patterns]
[Express of human papillomavirus, P53 and H-ras gene in laryngeal cancer]
[Expression and clinical significance of caspase-3,survivin and k-ras in non-small cell lung cancer.]
[Expression and mutation of p53 and H-ras genes in the carcinogenesis and development of gastric adenocarcinoma induced by MNNG in rats]
[Expressions of 8-OH-dG, k-ras, and p53 genes in pleural effusion cells and their clinical significances]
[Filamin A as a mediator of alterations in cancer cells].
[Findings of genetic changes in small intestinal carcinomas]
[Flow cytometric analysis of oncogene products]
[Frequency and clinicopathological associations of K-ras mutations in Venezuelan patients with colo-rectal cancer]
[Frequency of K-ras mutation in biliary and pancreatic tumors.]
[Gene K-ras mutation in cells of endometrial adenocarcinoma in women]
[General rules for the study of pancreatic cancer by molecular biological aspect]
[Genes, heredity and colorectal cancer]
[Genetic abnormalities of digestive tract adenocarcinomas and correlation with the histologic sequence of their development]
[Genetic alterations in human malignant tumor]
[Genetic alterations in preneoplastic and neoplastic injuries of the gallbladder]
[Genetic alterations in the genesis and development of ovarian cancer]
[Genetic investigations for lung carcinoma]
[Genetic pathways in colorectal cancer: interest for the pathologist]
[Genetic profile and molecular bases of pancreatic carcinogenesis]
[Immunohistological study for the ras oncogene products in colorectal cancer]
[Impact of prenylation inhibition on RAS mutant tumors in preclinical studies].
[K-ras gene mutation in gallbladder carcinoma]
[K-RAS gene mutations in patients with non-small cell lung cancer]
[K-ras mutation analysis in ovarian serous borderline and malignant tumors]
[K-ras mutation as a prognostic factor in colorectal carcinoma]
[K-ras mutations detection in paraaortic lymph nodes and its prognostic value after the surgical treatment of pancreas cancer]
[K-ras mutations in rectal cancer undergone preoperative radiotherapy]
[K-ras oncogene in bronchial cancer. Its current prognostic role and long-term therapeutic perspectives]
[miR-143 inhibits cell proliferation through targeted regulating the expression of K-ras gene in HeLa cells].
[Molecular alterations in Barrett's esophagus and adenocarcinoma]
[Molecular diagnosis of pancreatic cancer]
[Molecular markers in ovarian cancer]
[Molecular pathways of pancreatic carcinogenesis]
[Molecular-genetic analysis of clonal intratumoral heterogeneity on colorectal adenocarcinomas]
[Mouse models of K-ras-initiated oncogenesis]
[Multiple gene alterations involved in the processor of human gastric carcinogenesis]
[Mutation analysis of K-ras protooncogene in colorectal adenocarcinomas and polyps in Russian patients]
[Mutation scanning of short amplicons: optimization of DNA melting conditions].
[Mutational activation of H-ras and K-ras (Codon 12,61) genes in 7,12 dimethylbenz(a)anthracene induced rat ovarian tumors]
[Mutations in codon 61 in H-ras gene in liver tumors induced by strong and week carcinogens in mice]
[Mutations of APC and K-ras gene in aberrant crypt foci from human colon]
[New molecular targets in pancreatic cancer]
[Oncogenes and cancer of the larynx. EGFR, p21 ras and HPV-DNA infections]
[Pancreatic carcinogenesis. Clinical implications]
[Panitumumab]
[Pathogenesis of human cancer]
[Phenotype--genotype--correlation in ovarian neoplasia]
[Point mutation of K-ras gene in pancreatic carcinoma]
[Prognostic factors on surgical treatment for lung cancer]
[Pulmonary carcinogenesis susceptibility-associated single-nucleotide polymorphisms in K-ras intron 2 affect the binding of factor Gata-6 but not gene expression]
[Recent advances in gene change of pancreatic cancer]
[Relationship between EGFR and K-ras mutations and clinicopathological characteristics and response to erlotinib treatment in 301 Chinese patients with non-small cell lung cancer].
[Research advances of K-ras mutation in the prognosis and targeted therapy of gastric cancer].
[Research advances on bladder cancer associated genes]
[Role of Rho GTPase in inhibiting metastatic ability of human prostate cancer cell line PC-3 by omega-3 polyunsaturated fatty acid]
[Screening for K-ras mutations in colorectal and lung cancers by using a novel real-time PCR with ADx-K-ras kit and Sanger DNA sequencing].
[Sensitive detection of K-ras oncogene codon 12 mutations by nested PCR using mismatched primers and selective digestion of non-mutated PCR fragments with restriction enzyme]
[Serous genital carcinoma : Molecular pathogenesis and the role of tubal fimbria.]
[Significance of detection of K-ras gene mutations and CA19-9 in serum for diagnosis of pancreatic carcinoma]
[Specific immune against pancreatic cancer induced by dendritic cells pulsed with mutant K-ras peptide]
[Studies on association between the ATL and the development of multiple malignant neoplasms--analysis of 1171 cases of hematological malignancies during the past 24 years]
[Studies on the point mutation of ras oncogene in ovarian tumor]
[Study of 8-OH-dG and its correlation with several cancer related gene in lung cancer tissues]
[Study of angiogenesis in human colorectal carcinoma and its modulation by p53 and K-ras gene]
[Study of DNA microarray chip of associated genes of hydatidiform mole]
[Study of mesenchymal stem cells transfected with oncogenes differentiate into hepatocellular carcinoma of rats]
[Study on the mutations of p53 and K-ras gene in the cancer tissues and sputum cells of patients with lung cancer.]
[The clinical and pathological features, biomarker characteristics and prognosis analysis of lung adenosquamous carcinoma].
[The distribution of various type of oncogenes products in the tumor tissue of malignant mesothelioma]
[The effect of antisense H-ras on growth and metastasis of a high metastatic tumor model of human hepatoma in nude mice LCI-D20]
[The factors involved in invasive ability of endometrial carcinoma cells]
[The mouse ovarian surface epithelium cells (MOSE) transformation induced by c-myc/K-ras in]
[The RAS paradoxon of the EGFR-targeted therapy of colorectal cancer]
[The roles of H. pylori infection and K-ras gene mutation in gastric carcinogenesis]
[The study of correlation between the K-ras genotype and murine susceptibility to chemically induced lung neoplasms]
[Treatment of metastatic colorectal cancer: an illustration of the changes in the cancer paradigms].
[Tumor antigens presented to T helper lymphocytes--critical components of the cancer vaccine]
[Value of fecal and blood adenomatous polyposis coli gene and K-ras gene mutation detection in colorectal neoplasm screening]
Neoplasms by Site
Highly methylated genes in colorectal neoplasia: implications for screening.
Neoplasms, Germ Cell and Embryonal
K-RAS and N-RAS mutations in testicular germ cell tumors.
Neoplasms, Glandular and Epithelial
Analysis of K-ras gene mutations in rare pancreatic and ampullary tumours.
Gastric-type endocervical glandular neoplasms associated with aberrant p16 expression and K-RAS gene mutation in Peutz-Jeghers syndrome.
Neoplasms, Squamous Cell
Motility-related proteins as markers for head and neck squamous cell cancer.
Prognostic Significance of Rab27A and Rab27B Expression in Esophageal Squamous Cell Cancer.
Neoplastic Cells, Circulating
A Colorimetric Method for Detection of K-ras Codon 12 Point Mutations in DNA Extracted from Tissue and Peripheral Blood in Pancreatic Disorders.
A fast and convenient new technique to detect the therapeutic target, K-ras mutant, from peripheral blood in non-small cell lung cancer patients.
Detection of ras gene mutations in peripheral blood of carcinoma patients using CD45 immunomagnetic separation and nested mutant allele specific amplification.
Detection of tumor cells in blood using CD45 magnetic cell separation followed by nested mutant allele-specific amplification of p53 and K-ras genes in patients with colorectal cancer.
K-RAS Mutant Gene Found in Pancreatic Juice Activated Chromatin From Peri-ampullary Adenocarcinomas.
K-ras mutational analysis of polyclonal colorectal cancers identifies uniclonal circulating tumor cells.
Portal Venous Blood Circulation Supports Immunosuppressive Environment and Pancreatic Cancer Circulating Tumor Cell Activation.
The role of circulating tumor cells and K-ras mutations in patients with locally advanced rectal cancer: a prospective study.
Nephrosis
Fluvastatin Ameliorates Podocyte Injury in Proteinuric Rats via Modulation of Excessive Rho Signaling.
Losing their footing: Rac1 signaling causes podocyte detachment and FSGS.
Nephrotic Syndrome
ARHGDIA mutations cause nephrotic syndrome via defective RHO GTPase signaling.
Cdc42 deficiency induces podocyte apoptosis by inhibiting the Nwasp/stress fibers/YAP pathway.
Dosage-dependent Role of RAC1 in Podocyte Injury.
Nervous System Diseases
Disruption of the IQSEC2 transcript in a female with X;autosome translocation t(X;20)(p11.2;q11.2) and a phenotype resembling X-linked infantile spasms (ISSX) syndrome.
Signaling Through Rho GTPase Pathway as Viable Drug Target.
Small molecule targeting Cdc42-intersectin interaction disrupts Golgi organization and suppresses cell motility.
Neural Tube Defects
Rab23's genetic structure, function and related diseases: a review.
Rab23: what exactly does it traffic?
Neuralgia
Emerging strategies to promote improved functional outcome after peripheral nerve injury.
Involvement of Rac1 signalling pathway in the development and maintenance of acute inflammatory pain induced by bee venom injection.
microRNA-331-3p attenuates neuropathic pain following spinal cord injury via targeting RAP1A.
MicroRNA-340-5p relieved chronic constriction injury-induced neuropathic pain by targeting Rap1A in rat model.
miR-202 modulates the progression of neuropathic pain through targeting RAP1A.
MiR-203 Involves in Neuropathic Pain Development and Represses Rap1a Expression in Nerve Growth Factor Differentiated Neuronal PC12 Cells.
miR-590-3p Alleviates diabetic peripheral neuropathic pain by targeting RAP1A and suppressing infiltration by the T cells.
Neurilemmoma
Actin-rich protrusions and nonlocalized GTPase activation in Merlin-deficient schwannomas.
Altered adhesive structures and their relation to RhoGTPase activation in merlin-deficient Schwannoma.
Impaired intercellular adhesion and immature adherens junctions in merlin-deficient human primary schwannoma cells.
Inhibition of MEK pathway in vestibular schwannoma cell culture.
miRNA-7 attenuation in Schwannoma tumors stimulates growth by upregulating three oncogenic signaling pathways.
PAK kinase regulates Rac GTPase and is a potential target in human schwannomas.
Rearrangements of the intermediate filament GFAP in primary human schwannoma cells.
Neurobehavioral Manifestations
Synaptic proteins in CSF relate to Parkinson's disease stage markers.
Neuroblastoma
Anaplastic lymphoma kinase activates the small GTPase Rap1 via the Rap1-specific GEF C3G in both neuroblastoma and PC12 cells.
Cdc42 and RhoA reveal different spatio-temporal dynamics upon local stimulation with Semaphorin-3A.
CDC42 expression is altered by dioxin exposure and mediated by multilevel regulations via AhR in human neuroblastoma cells.
Cholesterol 24S-Hydroxylase Overexpression Inhibits the Liver X Receptor (LXR) Pathway by Activating Small Guanosine Triphosphate-Binding Proteins (sGTPases) in Neuronal Cells.
Cloning of a brain-type isoform of human Rab GDI and its expression in human neuroblastoma cell lines and tumor specimens.
Correction: Metformin impairs Rho GTPase signaling to induce apoptosis in neuroblastoma cells and inhibits growth of tumors in the xenograft mouse model of neuroblastoma.
Effect of let-7c on the PI3K/Akt/FoxO signaling pathway in hepatocellular carcinoma.
Effect of vitamin E succinate and a cAMP-stimulating agent on the expression of c-myc and N-myc and H-ras in murine neuroblastoma cells.
GDNF-induced cell signaling and neurite outgrowths are differentially mediated by GFRalpha1 isoforms.
GEFT, a Rho family guanine nucleotide exchange factor, regulates neurite outgrowth and dendritic spine formation.
Genetic alterations in brain tumors following 1,3-butadiene exposure in B6C3F1 mice.
Guanine Nucleotide Exchange Factors for RhoGTPases: Good Therapeutic Targets for Cancer Therapy?
Heterogeneity in retinoic acid signaling in neuroblastomas: Role of matrix metalloproteinases in retinoic acid-induced differentiation.
Identification of H, K, and N-ras point mutations in stage IB cervical carcinoma.
In contrast to EGFr gene overexpression, H-ras gene expression decreases in human gliomas.
Increased Ras expression and caspase-independent neuroblastoma cell death: possible mechanism of spontaneous neuroblastoma regression.
Inhibition of a new differentiation pathway in neuroblastoma by copy number defects of N-myc, Cdc42, and nm23 genes.
Inhibition of farnesyl-protein-transferase in neuroblastoma cells by alpha-hydroxyfarnesylphosphonate.
Jararhagin, a snake venom metalloprotease-disintegrin, activates the Rac1 GTPase and stimulates neurite outgrowth in neuroblastoma cells.
JNK phosphorylation of paxillin, acting through the Rac1 and Cdc42 signaling cascade, mediates neurite extension in N1E-115 cells.
Low frequency of ras gene mutations in neuroblastomas, pheochromocytomas, and medullary thyroid cancers.
MeHg affects the activation of FAK, Src, Rac1 and Cdc42, critical proteins for cell movement in PDGF-stimulated SH-SY5Y neuroblastoma cells.
Metformin impairs Rho GTPase signaling to induce apoptosis in neuroblastoma cells and inhibits growth of tumors in the xenograft mouse model of neuroblastoma.
miR-149 inhibits cell proliferation and enhances chemosensitivity by targeting CDC42 and BCL2 in neuroblastoma.
Molecular dissection of the Rho-associated protein kinase (p160ROCK)-regulated neurite remodeling in neuroblastoma N1E-115 cells.
NEDD9 regulates 3D migratory activity independent of the Rac1 morphology switch in glioma and neuroblastoma.
Neuroblastoma: inhibition of progression (Part II). Basic science in pediatric surgery.
Nonsteroidal anti-inflammatory drugs attenuate amyloid-? protein-induced actin cytoskeletal reorganization through Rho signaling modulation.
NRAS isoforms differentially affect downstream pathways, cell growth, and cell transformation.
Occurrence of two types of secretory vesicles in the human neuroblastoma SH-SY5Y.
PAR-6-PAR-3 mediates Cdc42-induced Rac activation through the Rac GEFs STEF/Tiam1.
Phosphatidylinositol 3-kinase, Cdc42, and Rac1 act downstream of Ras in integrin-dependent neurite outgrowth in N1E-115 neuroblastoma cells.
Rab15 alternative splicing is altered in spheres of neuroblastoma cells.
Rab15 expression correlates with retinoic acid-induced differentiation of neuroblastoma cells.
Rac GTPase regulation of 3D invasion in neuroblastomas lacking MYCN amplification.
Rac1 and Cdc42 but not RhoA or Rho kinase activities are required for neurite outgrowth induced by the Netrin-1 receptor DCC (deleted in colorectal cancer) in N1E-115 neuroblastoma cells.
Rare frequencey of point mutations for codon 12, 13 and 61 of ras gene in italian neuroblastoma.
Rho family GTPases and neuronal growth cone remodelling: relationship between increased complexity induced by Cdc42Hs, Rac1, and acetylcholine and collapse induced by RhoA and lysophosphatidic acid.
SIGNAL TRANSDUCTION. Membrane potential modulates plasma membrane phospholipid dynamics and K-Ras signaling.
Silencing of CDC42 inhibits neuroblastoma cell proliferation and transformation.
Specific expression of the ras-related rab3A gene in human normal and malignant neuroendocrine cells.
Stathmin mediates neuroblastoma metastasis in a tubulin-independent manner via RhoA/ROCK signaling and enhanced transendothelial migration.
Stimulation of PrP(C) retrograde transport toward the endoplasmic reticulum increases accumulation of PrP(Sc) in prion-infected cells.
Synthetic Rab3A effector domain peptide stimulates inositol 1,4,5-trisphosphate production in various permeabilized cells.
The G12 family of heterotrimeric G proteins and Rho GTPase mediate Sonic hedgehog signalling.
The small GTPase Rab6B, a novel Rab6 subfamily member, is cell-type specifically expressed and localised to the Golgi apparatus.
Vasoactive intestinal peptide-induced neurite remodeling in human neuroblastoma SH-SY5Y cells implicates the Cdc42 GTPase and is independent of Ras-ERK pathway.
[Gene regulation during NGF--induced differentiation of neuroblastoma cells]
Neurodegenerative Diseases
Allosteric binding sites in Rab11 for potential drug candidates.
Altered Distribution of RhoA in Alzheimer's Disease and AbetaPP Overexpressing Mice.
Altered distribution of RhoA in Alzheimer's disease and AbetaPP overexpressing mice.
Coordination of synaptic vesicle trafficking and turnover by the Rab35 signaling network.
ENU mutagenesis identifies mice modeling Warburg Micro Syndrome with sensory axon degeneration caused by a deletion in Rab18.
Functional enhancement and protection of dopaminergic terminals by RAB3B overexpression.
Guanine nucleotide induced conformational change of Cdc42 revealed by hydrogen/deuterium exchange mass spectrometry.
Implication of rho GTPases in neurodegenerative diseases.
Loss of endosomal recycling factor RAB11 coupled with complex regulation of MAPK/ERK/AKT signaling in postmortem spinal cord specimens of sporadic amyotrophic lateral sclerosis patients.
Mechanistic Differences of Activation of Rac1P29S and Rac1A159V.
Overexpression cdc42 attenuates isoflurane-induced neurotoxicity in developmental brain of rats.
Perspectives of RAS and RHEB GTPase Signaling Pathways in Regenerating Brain Neurons.
Rab11-mediated recycling endosome role in nervous system development and neurodegenerative diseases.
RAB21 interacts with TMED10 and modulates its localization and abundance.
Neuroectodermal Tumors, Primitive
miR-431 Promotes Metastasis of Pancreatic Neuroendocrine Tumors by Targeting DAB2 Interacting Protein, a Ras GTPase Activating Protein Tumor Suppressor.
Primitive neuroectodermal tumors after prophylactic central nervous system irradiation in children. Association with an activated K-ras gene.
Neuroendocrine Tumors
Analysis of K-ras, N-ras, H-ras, and p53 in lung neuroendocrine neoplasms.
Cdc42 and Rac1 activity is reduced in human pheochromocytoma and correlates with FARP1 and ARHGEF1 expression.
Detection of K-ras point mutation at codon 12 in pancreatic diseases: a study in a Brazilian casuistic.
Frequent RASSF1A promoter hypermethylation and K-ras mutations in pancreatic carcinoma.
miR-431 Promotes Metastasis of Pancreatic Neuroendocrine Tumors by Targeting DAB2 Interacting Protein, a Ras GTPase Activating Protein Tumor Suppressor.
Prognostic factors in histopathology of lung cancer.
Neurofibroma
Tranilast inhibits the expression of genes related to epithelial-mesenchymal transition and angiogenesis in neurofibromin-deficient cells.
Neurofibroma, Plexiform
Correction: Genetic disruption of the small GTPase RAC1 prevents plexiform neurofibroma formation in mice with neurofibromatosis type 17.
Genetic disruption of the small GTPase RAC1 prevents plexiform neurofibroma formation in mice with neurofibromatosis type 17.
Neurofibromatoses
Characterization of a GTPase-activating protein for the Ras-related Ral protein.
Classic Ras Proteins Promote Proliferation and Survival via Distinct Phosphoproteome Alterations in Neurofibromin-Null Malignant Peripheral Nerve Sheath Tumor Cells.
Correction: Genetic disruption of the small GTPase RAC1 prevents plexiform neurofibroma formation in mice with neurofibromatosis type 17.
Genetic disruption of the small GTPase RAC1 prevents plexiform neurofibroma formation in mice with neurofibromatosis type 17.
Heterogeneous amino acids in Ras and Rap1A specifying sensitivity to GAP proteins.
Inactivation of the NF1 gene in human melanoma and neuroblastoma cell lines without impaired regulation of GTP.Ras.
Infrequent involvement of mutations on neurofibromatosis type 1, H-ras, K-ras and N-ras in urothelial tumors.
Lens induction requires attenuation of ERK signaling by Nf1.
Microarray-based copy number analysis of neurofibromatosis type-1 (NF1)-associated malignant peripheral nerve sheath tumors reveals a role for Rho-GTPase pathway genes in NF1 tumorigenesis.
Neurofibromatosis-like phenotype in Drosophila caused by lack of glucosylceramide extension.
Neurofibromin is required for barrel formation in the mouse somatosensory cortex.
Nf1 deficiency causes Ras-mediated granulocyte/macrophage colony stimulating factor hypersensitivity and chronic myeloid leukaemia.
NF1 tumor suppressor protein and mRNA in skeletal tissues of developing and adult normal mouse and NF1-deficient embryos.
Suppression of oncogenic Ras by mutant neurofibromatosis type 1 genes with single amino acid substitutions.
The catalytic domain of the neurofibromatosis type 1 gene product stimulates ras GTPase and complements ira mutants of S. cerevisiae.
The guanine triphosphatase (GTPase) activating protein (GAP)-related domain of the neurofibromatosis type 1 gene is not mutated in neural crest-derived sporadic tumours.
The receptor tyrosine kinase Alk controls neurofibromin functions in Drosophila growth and learning.
Neurofibromatosis 1
Classic Ras Proteins Promote Proliferation and Survival via Distinct Phosphoproteome Alterations in Neurofibromin-Null Malignant Peripheral Nerve Sheath Tumor Cells.
Glioma formation in neurofibromatosis 1 reflects preferential activation of K-RAS in astrocytes.
Heterogeneous amino acids in Ras and Rap1A specifying sensitivity to GAP proteins.
Infrequent involvement of mutations on neurofibromatosis type 1, H-ras, K-ras and N-ras in urothelial tumors.
Lens induction requires attenuation of ERK signaling by Nf1.
Neurofibromatosis-like phenotype in Drosophila caused by lack of glucosylceramide extension.
Neurofibromin is required for barrel formation in the mouse somatosensory cortex.
Nf1 deficiency causes Ras-mediated granulocyte/macrophage colony stimulating factor hypersensitivity and chronic myeloid leukaemia.
NF1 tumor suppressor protein and mRNA in skeletal tissues of developing and adult normal mouse and NF1-deficient embryos.
The catalytic domain of the neurofibromatosis type 1 gene product stimulates ras GTPase and complements ira mutants of S. cerevisiae.
The guanine triphosphatase (GTPase) activating protein (GAP)-related domain of the neurofibromatosis type 1 gene is not mutated in neural crest-derived sporadic tumours.
The receptor tyrosine kinase Alk controls neurofibromin functions in Drosophila growth and learning.
Neurofibromatosis 2
Isolation of mutations in the Drosophila homologues of the human Neurofibromatosis 2 and yeast CDC42 genes using a simple and efficient reverse-genetic method.
Neurofibrosarcoma
4-Hydroxytamoxifen induces autophagic death through K-Ras degradation.
Classic Ras Proteins Promote Proliferation and Survival via Distinct Phosphoproteome Alterations in Neurofibromin-Null Malignant Peripheral Nerve Sheath Tumor Cells.
Critical role of PTEN for development and progression of nerve sheath tumors in neurofibromatosis type 1.
Feasibility of using NF1-GRD and AAV for gene replacement therapy in NF1-associated tumors.
Microarray-based copy number analysis of neurofibromatosis type-1 (NF1)-associated malignant peripheral nerve sheath tumors reveals a role for Rho-GTPase pathway genes in NF1 tumorigenesis.
PTEN dosage is essential for neurofibroma development and malignant transformation.
R-Ras subfamily proteins elicit distinct physiologic effects and phosphoproteome alterations in neurofibromin-null MPNST cells.
Neuroinflammatory Diseases
Recombinant Slit2 attenuates neuroinflammation after surgical brain injury by inhibiting peripheral immune cell infiltration via Robo1-srGAP1 pathway in a rat model.
Neuroma, Acoustic
Inhibition of MEK pathway in vestibular schwannoma cell culture.
Neutropenia
Congenital neutropenia.
Hematologic toxicity assessment in solid tumor patients treated with cetuximab: A pooled analysis of 18 randomized controlled trials.
Study of oncogenic transformation in ex vivo expanded mesenchymal cells, from paediatric bone marrow.
Nevus
Analysis of mutations in B-RAF, N-RAS, and H-RAS genes in the differential diagnosis of Spitz nevus and spitzoid melanoma.
Analysis of N- and K-ras mutations in the distinctive tumor progression phases of melanoma.
Genetic similarities between Spitz nevus and Spitzoid melanoma in children.
Rab33A: Characterization, Expression, and Suppression by Epigenetic Modification.
ras mutations in human melanotic lesions: K-ras activation is a frequent and early event in melanoma development.
Nevus, Epithelioid and Spindle Cell
Analysis of mutations in B-RAF, N-RAS, and H-RAS genes in the differential diagnosis of Spitz nevus and spitzoid melanoma.
Genetic similarities between Spitz nevus and Spitzoid melanoma in children.
Niemann-Pick Disease, Type C
New insights into the interplay between autophagy, gut microbiota and inflammatory responses in IBD.
Niemann-Pick Diseases
New insights into the interplay between autophagy, gut microbiota and inflammatory responses in IBD.
Nijmegen Breakage Syndrome
Polymorphisms in DNA repair and metabolic genes in bladder cancer.
Non-alcoholic Fatty Liver Disease
Gene expression profiling reveals key genes and pathways related to the development of non-alcoholic fatty liver disease.
Integrated Analysis and Identification of Novel Biomarkers in Parkinson's Disease.
The balance of protein farnesylation and geranylgeranylation during the progression of nonalcoholic fatty liver disease.
Noonan Syndrome
Activating mutations in RRAS underlie a phenotype within the RASopathy spectrum and contribute to leukaemogenesis.
Biochemical and Functional Characterization of Germ Line KRAS Mutations.
Clinical report of a brain magnetic resonance imaging finding in Noonan syndrome.
CP6 Anopthalmia and dysembryoplastic neuroepithelial tumours in a family with Noonan syndrome and a novel PTPN11 mutation.
Development of Noonan syndrome by deregulation of allosteric SOS autoactivation.
Functional Dysregulation of CDC42 Causes Diverse Developmental Phenotypes.
M-Ras/Shoc2 signaling modulates E-cadherin turnover and cell-cell adhesion during collective cell migration.
Molecules linked to Ras signaling as therapeutic targets in cardiac pathologies.
Obesity
Carpenter syndrome: extended RAB23 mutation spectrum and analysis of nonsense-mediated mRNA decay.
Improving detection of colorectal cancer.
Neuronal Rap1 Regulates Energy Balance, Glucose Homeostasis, and Leptin Actions.
Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity.
Rab GTPases implicated in inherited and acquired disorders.
Rab18 dynamics in adipocytes in relation to lipogenesis, lipolysis and obesity.
Rab23 and developmental disorders.
RAB23 mutations in Carpenter syndrome imply an unexpected role for hedgehog signaling in cranial-suture development and obesity.
Rap1 in the VMH regulates glucose homeostasis.
Obesity, Maternal
Placental Ras Regulates Inflammation Associated with Maternal Obesity.
Ocular Hypertension
RhoA GTPase-induced ocular hypertension in a rodent model is associated with increased fibrogenic activity in the trabecular meshwork.
Oculocerebrorenal Syndrome
Lowe syndrome protein OCRL1 interacts with Rac GTPase in the trans-Golgi network.
Lowe syndrome protein Ocrl1 is translocated to membrane ruffles upon Rac GTPase activation: a new perspective on Lowe syndrome pathophysiology.
Rab35 GTPase and OCRL phosphatase remodel lipids and F-actin for successful cytokinesis.
Rab35 GTPase Triggers Switch-like Recruitment of the Lowe Syndrome Lipid Phosphatase OCRL on Newborn Endosomes.
Odontogenic Tumors
K-Ras gene status and expression of Ras/mitogen-activated protein kinase (MAPK) signaling molecules in ameloblastomas.
Oligodendroglioma
Combined erbB gene overexpression and decreased H-ras gene expression in human gliomas.
Opisthorchiasis
[Molecular genetic approaches in parasitology (in case of opisthorchiasis)]
Optic Nerve Injuries
Dock3 attenuates neural cell death due to NMDA neurotoxicity and oxidative stress in a mouse model of normal tension glaucoma.
Enhanced survival and regeneration of axotomized retinal neurons by repeated delivery of cell-permeable C3-like Rho antagonists.
Osteoarthritis
Cdc42 Is Essential for Both Articular Cartilage Degeneration and Subchondral Bone Deterioration in Experimental Osteoarthritis.
Signaling through the small G-protein Cdc42 is involved in insulin-like growth factor-I resistance in aging articular chondrocytes.
Wnt and Rho GTPase signaling in osteoarthritis development and intervention: implications for diagnosis and therapy.
Osteonecrosis
[Expression of Ras-Associated Protein 1 in the Vascular Endothelium of Bone Tissue with Non-Traumatic Osteonecrosis of Femoral Head].
Osteopetrosis
Rac deletion in osteoclasts causes severe osteopetrosis.
Osteoporosis
Cdc42 GTPase-activating protein deficiency promotes genomic instability and premature aging-like phenotypes.
Involvement of miR-337 in high glucose-suppressed osteogenic differentiation in bone marrow mesenchymal stem cells via negative regulation of Rap1A.
Osteosarcoma
Analyzing time-series microarray data reveals key genes in spinal cord injury.
Carcinosarcoma colliding osteosarcoma of the pancreas: a rare case report of multiple clonal originated pancreatic tumors.
Clinicopathologic implications of MDM2, p53 and K-ras gene alterations in osteosarcomas: MDM2 amplification and p53 mutations found in progressive tumors.
Daphnetin inhibits invasion and migration of LM8 murine osteosarcoma cells by decreasing RhoA and Cdc42 expression.
Differential oncogenic Ras signaling and senescence in tumor cells.
Driven to Death: Inhibition of Farnesylation Increases Ras Activity in Osteosarcoma and Promotes Growth Arrest and Cell Death.
Erratum: Ras-related protein Rap2c promotes the migration and invasion of human osteosarcoma cells.
Ezrin-related Phosphoinositide pathway modifies RhoA and Rac1 in human osteosarcoma cell lines.
Human herpesvirus 6A ts suppresses both transformation by H-ras and transcription by the H-ras and human immunodeficiency virus type 1 promoters.
Identification of a p53 target, CD137L, that mediates growth suppression and immune response of osteosarcoma cells.
Identification of biomarkers associated with the recurrence of osteosarcoma using ceRNA regulatory network analysis.
Involvement of small G protein RhoB in the regulation of proliferation, adhesion and migration by dexamethasone in osteoblastic cells.
LINC00665 Facilitates the Malignant Processes of Osteosarcoma by Increasing the RAP1B Expression via Sponging miR-708 and miR-142-5p.
MicroRNA-16 suppressed the invasion and migration of osteosarcoma by directly inhibiting RAB23.
MicroRNA-665 suppressed the invasion and metastasis of osteosarcoma by directly inhibiting RAB23.
MiR-193a-3p and miR-193a-5p suppress the metastasis of human osteosarcoma cells by down-regulating Rab27B and SRR, respectively.
miR-29a inhibits adhesion, migration, and invasion of osteosarcoma cells by suppressing CDC42.
Molecular analysis of p53, MDM2 and H-ras genes in low-grade central osteosarcoma.
Molecular analysis of p53, MDM2, and H-ras genes in osteosarcoma and malignant fibrous histiocytoma of bone in patients older than 40 years.
PI3K? isoform-dependent activation of RhoA regulates Wnt5a-induced osteosarcoma cell migration.
Ras-related protein Rap2c promotes the migration and invasion of human osteosarcoma cells.
Role of vasodilator-stimulated phosphoprotein in RANKL-differentiated murine macrophage RAW264.7 cells: Modulation of NF-?B, c-Fos and NFATc1 transcription factors.
The Focal Adhesion-Localized CdGAP Regulates Matrix Rigidity Sensing and Durotaxis.
Ovarian Cysts
Expression of motility-related molecule Cdc42 in endometrial tissue in women with adenomyosis and ovarian endometriomata.
Ovarian Neoplasms
A Novel Pharmacologic Activity of Ketorolac for Therapeutic Benefit in Ovarian Cancer Patients.
Abnormal expression of the retinoblastoma gene in ovarian neoplasms and correlation to p53 and K-ras mutations.
Activated protein C upregulates ovarian cancer cell migration and promotes unclottability of the cancer cell microenvironment.
Androgen-related expression of G-proteins in ovarian cancer.
Biochip for K-ras mutation screening in ovarian cancer.
Biomarkers in the ovary.
BMP4 induces EMT and Rho GTPase activation in human ovarian cancer cells.
Compressive Stimulation Enhances Ovarian Cancer Proliferation, Invasion, Chemoresistance, and Mechanotransduction via CDC42 in a 3D Bioreactor.
Coordinately up-regulated genes in ovarian cancer.
Crystal structures of PRK1 in complex with the clinical compounds lestaurtinib and tofacitinib reveal ligand induced conformational changes.
Cucurbit [7] uril encapsulated cisplatin overcomes resistance to cisplatin induced by Rab25 overexpression in an intraperitoneal ovarian cancer model.
CXCL12 promotes human ovarian cancer cell invasion through suppressing ARHGAP10 expression.
Cytokinesis failure due to derailed integrin traffic induces aneuploidy and oncogenic transformation in vitro and in vivo.
Detection and clinical correlations of ras gene mutations in human ovarian tumors.
Downregulation of Rab23 inhibits proliferation, invasion, and metastasis of human ovarian cancer.
Exosomal CD47 Plays an Essential Role in Immune Evasion in Ovarian Cancer.
FSH receptor binding inhibitor depresses carcinogenesis of ovarian cancer via decreasing levels of K-Ras, c-Myc and FSHR.
FSH receptor binding inhibitor impacts K-Ras and c-Myc of ovarian cancer and signal pathway.
G?13 Stimulates the Tyrosine Phosphorylation of Ric-8A.
Gene expression and prognostic significance in ovarian cancer.
Glucocorticoids mediate induction of microRNA-708 to suppress ovarian cancer metastasis through targeting Rap1B.
Human ovarian cancer of the surface epithelium.
Hyaluronan-CD44 interaction with IQGAP1 promotes Cdc42 and ERK signaling, leading to actin binding, Elk-1/estrogen receptor transcriptional activation, and ovarian cancer progression.
Hypoxia-induced exosomes contribute to a more aggressive and chemoresistant ovarian cancer phenotype: a novel mechanism linking STAT3/Rab proteins.
Hypoxia-inducible factor 1 alpha is required for the tumourigenic and aggressive phenotype associated with Rab25 expression in ovarian cancer.
In Vivo Activity of Combined PI3K/mTOR and MEK Inhibition in a KrasG12D;Pten Deletion Mouse Model of Ovarian Cancer.
Inhibitors of Ras signal transduction as antitumor agents.
K-ras alterations in Danish ovarian tumour patients. From the Danish "Malova" Ovarian Cancer study.
K-ras mutations in mucinous ovarian tumors: a clinicopathologic and molecular study of 95 cases.
lncRNA UCA1-Mediated Cdc42 Signaling Promotes Oncolytic Vaccinia Virus Cell-to-Cell Spread in Ovarian Cancer.
Long noncoding RNA UCA1 enhances sensitivity to oncolytic vaccinia virus by sponging miR-18a/miR-182 and modulating the Cdc42/filopodia axis in colorectal cancer.
Low-dose glucocorticoids suppresses ovarian tumor growth and metastasis in an immunocompetent syngeneic mouse model.
Lysophosphatidic Acid Stimulates Ovarian Cancer Cell Migration via a Ras-MEK Kinase 1 Pathway.
Major oncogenes and tumor suppressor genes involved in epithelial ovarian cancer (review).
MCAM is a novel metastasis marker and regulates spreading, apoptosis and invasion of ovarian cancer cells.
MicroRNA-134-3p is a novel potential inhibitor of human ovarian cancer stem cells by targeting RAB27A.
Molecular analysis of peritoneal fluid in ovarian cancer patients.
Ovarian adenocarcinomas in the laying hen and women share similar alterations in p53, ras, and HER-2/neu.
Overexpression of Rab27B is correlated with distant metastasis and poor prognosis in ovarian cancer.
p27 and cyclin D1 abnormalities in uterine papillary serous carcinoma.
Prognostic significance of ras/p21 alterations in human ovarian cancer.
R-Ketorolac Targets Cdc42 and Rac1 and Alters Ovarian Cancer Cell Behaviors Critical for Invasion and Metastasis.
Rab23 promotes the cisplatin resistance of ovarian cancer via the Shh-Gli-ABCG2 signaling pathway.
Rap1A promotes ovarian cancer metastasis via activation of ERK/p38 and notch signaling.
RCC2, a regulator of the RalA signaling pathway, is identified as a novel therapeutic target in cisplatin-resistant ovarian cancer.
Regulation and functional significance of CDC42 alternative splicing in ovarian cancer.
RHPN1?AS1 promotes ovarian carcinogenesis by sponging miR?6884?5p thus releasing TOP2A mRNA.
Role of Apoptotic Regulators in Human Epithelial Ovarian Cancer.
Role of K-ras and Pten in the development of mouse models of endometriosis and endometrioid ovarian cancer.
Silencing of H-ras gene expression by retrovirus-mediated siRNA decreases transformation efficiency and tumorgrowth in a model of human ovarian cancer.
Simvastatin is a potential candidate drug in ovarian clear cell carcinomas.
SKP2/P27Kip1 pathway is associated with Advanced Ovarian Cancer in Saudi Patients.
The R-enantiomer of ketorolac reduces ovarian cancer tumor burden in vivo.
The role of Rho GTPase in cell stiffness and cisplatin resistance in ovarian cancer cells.
Use of ras-transformed human ovarian surface epithelial cells as a model for studying ovarian cancer.
[Alterations of c-Myc and c-erbB-2 genes in ovarian tumours]
[Genetic alterations in the genesis and development of ovarian cancer]
[Lysophosphatidic acid (LPA) stimulates invasion and metastatic colonization of ovarian cancer cells through Rac activation].
[New technology of diagnosis of ovarian cancer]
[The mouse ovarian surface epithelium cells (MOSE) transformation induced by c-myc/K-ras in]
Paget Disease, Extramammary
PI3K, Rac1 and pPAK1 are overexpressed in extramammary Paget's disease.
Pancreatic Cyst
A comparative analysis of K-ras mutation and carcinoembryonic antigen in pancreatic cyst fluid.
High proportion of mutant K-ras gene in pancreatic juice of patients with pancreatic cystic lesions.
Incidental Cystic Lesions in the Pancreas: Resect? EUS? Follow?
Pancreatic cyst fluid DNA analysis in evaluating pancreatic cysts: a report of the PANDA study.
The added value of molecular testing in small pancreatic cysts.
The role of molecular analysis in the diagnosis and surveillance of pancreatic cystic neoplasms.
The role of pancreatic cyst fluid molecular analysis in predicting cyst pathology.
[Molecular diagnosis of pancreatic cancer]
Pancreatic Diseases
Analysis of K-ras codon 12 point mutations using duodenal lavage fluid for diagnosis of pancreatic carcinoma.
Analysis of K-ras gene mutation in hyperplastic duct cells of the pancreas without pancreatic disease.
Analysis of K-ras mutations in pancreatic tissue after fine needle aspirates.
Detecting K-ras and p53 gene mutation from stool and pancreatic juice for diagnosis of early pancreatic cancer.
Detection of K-ras gene mutations at codon 12 in the pancreatic juice of patients with intraductal papillary mucinous tumors of the pancreas.
Detection of K-ras point mutation at codon 12 in pancreatic diseases: a study in a Brazilian casuistic.
Detection of point mutation in K-ras oncogene at codon 12 in pancreatic diseases.
Diagnosis of pancreatic cancer by cytology and measurement of oncogene and tumor markers in pure pancreatic juice aspirated by endoscopy.
Diagnosis of pancreatic cancer by detecting telomerase activity in pancreatic juice: comparison with K-ras mutations.
Evaluation of the diagnostic value of serum tumor markers, and fecal k-ras and p53 gene mutations for pancreatic cancer.
Identification of K-ras mutations in pancreatic juice in the early diagnosis of pancreatic cancer.
K-Ras mutations and benign pancreatic disease.
K-ras mutations in stools and tissue samples from patients with malignant and nonmalignant pancreatic diseases.
K-ras mutations in tissue and stool samples from patients with pancreatic cancer and chronic pancreatitis.
Low correspondence between K-ras mutations in pancreatic cancer tissue and detection of K-ras mutations in circulating DNA.
Molecular diagnosis of early pancreatic ductal adenocarcinoma in high-risk patients.
Phenotypic changes in mouse pancreatic stellate cell Ca2+ signaling events following activation in culture and in a disease model of pancreatitis.
Significance of K-ras codon 12 point mutation in pancreatic juice in the diagnosis of carcinoma of the pancreas.
Significance of K-ras mutation and CEA level in pancreatic juice in the diagnosis of pancreatic cancer.
[An application value of detecting K-ras and p53 gene mutation in the stool and pure pancreatic juice for diagnosis of early pancreatic cancer]
[K-ras mutation in pancreatic juice from patients with pancreatic carcinoma]
[Sensitivity and specificity of tumor markers in cancer diagnosis]
Pancreatic Intraductal Neoplasms
Molecular and immunohistochemical analysis of intraductal papillary neoplasms of the biliary tract.
Pancreatic Neoplasms
4-Hydroxytamoxifen induces autophagic death through K-Ras degradation.
?-catenin-activated autocrine PDGF/Src signaling is a therapeutic target in pancreatic cancer.
A case of small pancreatic cancer diagnosed by serial follow-up studies promptly by a positive K-ras point mutation in pure pancreatic juice.
A chronocoulometric LNA sensor for amplified detection of K-ras mutation based on site-specific DNA cleavage of restriction endonuclease.
A G-quadruplex-binding compound showing anti-tumour activity in an in vivo model for pancreatic cancer.
A gene expression signature associated with "K-Ras addiction" reveals regulators of EMT and tumor cell survival.
A highly sensitive method for K-ras mutation detection is useful in diagnosis of gastrointestinal cancer.
A homologous promoterless K-ras cDNA targeting endogenous K-ras expression inhibits human pancreatic cancer cell growth in vitro and in vivo.
A Macropinocytosis-Intensifying Albumin Domain-Based scFv Antibody and Its Conjugate Directed against K-Ras Mutant Pancreatic Cancer.
A meta-analysis of the diagnostic value of detecting K-ras mutation in pancreatic juice as a molecular marker for pancreatic cancer.
A New Strategy to Control and Eradicate "Undruggable" Oncogenic K-RAS-Driven Pancreatic Cancer: Molecular Insights and Core Principles Learned from Developmental and Evolutionary Biology.
A novel strategy for inhibiting growth of human pancreatic cancer cells by blocking cyclin-dependent kinase activity.
A prospective study of K-ras mutations in the plasma of pancreatic cancer patients.
A recombinantly tailored ?-defensin that displays intensive macropinocytosis-mediated uptake exerting potent efficacy against K-Ras mutant pancreatic cancer.
A triple combination of atorvastatin, celecoxib and tipifarnib strongly inhibits pancreatic cancer cells and xenograft pancreatic tumors.
Absence of K-ras mutations in the pancreatic parenchyma of patients with chronic pancreatitis.
Accomplishments in 2007 in biologic markers for gastrointestinal cancers.
Activated K-ras and INK4a/Arf deficiency cooperate during the development of pancreatic cancer by activation of Notch and NF-?B signaling pathways.
Activated K-Ras and INK4a/Arf deficiency promote aggressiveness of pancreatic cancer by induction of EMT consistent with cancer stem cell phenotype.
Activation of Raf-1 in human pancreatic adenocarcinoma.
Adenocarcinoma of the pancreas: detection of occult metastases in regional lymph nodes by a polymerase chain reaction-based assay.
Adenovirus-mediated anti-K-ras ribozyme induces apoptosis and growth suppression of human pancreatic carcinoma.
Adjusting serum concentrations of organochlorine compounds by lipids and symptoms: a causal framework for the association with K-ras mutations in pancreatic cancer.
Advances in Molecular Pathology and Treatment of Periampullary Cancers.
AKT1 (E17K) Mutation in Pancreatic Cancer.
An adenosine-mediated signaling pathway suppresses prenylation of the GTPase Rap1B and promotes cell scattering.
An anti-K-ras ribozyme suppresses oncogene expression and cell growth of human pancreatic cancer.
An Epidemiological Overview of Environmental and Genetic Risk Factors of Pancreatic Cancer.
An oncolytic adenovirus defective in pRb-binding (dl922-947) can efficiently eliminate pancreatic cancer cells and tumors in vivo in combination with 5-FU or gemcitabine.
Analysis of K-ras gene mutations in human pancreatic cancer cell lines and in bile samples from patients with pancreatic and biliary cancers.
Analysis of K-ras gene mutations in rare pancreatic and ampullary tumours.
Analysis of K-Ras Interactions by Biotin Ligase Tagging.
Analysis of K-ras oncogene mutations in chronic pancreatitis with ductal hyperplasia.
Analysis of Kras gene from induced pancreatic cancer rats administered with Momordicacharantia and Ocimumbasilicum leaf extracts.
Anti-proliferative and proapoptotic effects of benzyl isothiocyanate on human pancreatic cancer cells is linked to death receptor activation and RasGAP/Rac1 down-modulation.
Antisense oligonucleotides specific to mutated K-ras genes inhibit invasiveness of human pancreatic cancer cell lines.
Antisense therapy specific to mutated K-ras gene in hamster pancreatic cancer model. Can it inhibit the growth of 5-FU and MMC-resistant metastatic and remetastatic cell lines?
Antitumor activity of erlotinib in combination with gemcitabine in in vitro and in vivo models of KRAS-mutated pancreatic cancers.
Aphanin, a triterpenoid from Amoora rohituka inhibits K-Ras mutant activity and STAT3 in pancreatic carcinoma cells.
Approaches to inhibiting oncogenic K-Ras.
ARF6, induced by mutant Kras, promotes proliferation and Warburg effect in pancreatic cancer.
ARHGEF15 overexpression worsens the prognosis in patients with pancreatic ductal adenocarcinoma through enhancing the motility and proliferative activity of the cancer cells.
Assembling Mn:ZnSe quantum dots-siRNA nanoplexes for gene silencing in tumor cells.
Association between coffee drinking and K-ras mutations in exocrine pancreatic cancer. PANKRAS II Study Group.
Autophagy in pancreatic cancer pathogenesis and treatment.
BART inhibits pancreatic cancer cell invasion by inhibiting ARL2-mediated RhoA inactivation.
Beyond the Genomic Mutation: Rethinking the Molecular Biomarkers of K-RAS Dependency in Pancreatic Cancers.
Biliopancreatic malignancy: screening the at risk patient with molecular markers.
Biodegradable nanoparticle-mediated K-ras down regulation for pancreatic cancer gene therapy.
Biologic therapies for advanced pancreatic cancer.
Blockage of intermediate-conductance Ca2+-activated K+ channels inhibit human pancreatic cancer cell growth in vitro.
BRAF and K-ras gene mutations in human pancreatic cancers.
Cdc42 mediates cancer cell chemotaxis in perineural invasion.
CDDO-Me: A Novel Synthetic Triterpenoid for the Treatment of Pancreatic Cancer.
Cetuximab delivery and antitumor effects are enhanced by mild hyperthermia in a xenograft mouse model of pancreatic cancer.
Characterization of the mutations of the K-ras, p53, p16, and SMAD4 genes in 15 human pancreatic cancer cell lines.
Cigarette smoking and K-ras mutations in pancreas, lung and colorectal adenocarcinomas: Etiopathogenic similarities, differences and paradoxes.
Clear cell carcinoma of the pancreas: an adenocarcinoma with ductal phenotype.
Clinical usefulness of K-ras gene mutation detection and cytology in pancreatic juice in the diagnosis and screening of pancreatic cancer.
Clinical validity of detecting K-ras mutations for the diagnosis of exocrine pancreatic cancer: a prospective study in a clinically-relevant spectrum of patients.
Clinical value of K-ras codon 12 analysis and endobiliary brush cytology for the diagnosis of malignant extrahepatic bile duct stenosis.
Coffee, K-ras mutations and pancreatic cancer: a heterogeneous aetiology or an artefact?
Coffee, pancreatic cancer, and K-ras mutations: updating the research agenda.
Combination treatment strategy for pancreatic cancer involving the novel HDAC inhibitor MPT0E028 with a MEK inhibitor beyond K-Ras status.
Combined silencing of K-ras and Akt2 oncogenes achieves synergistic effects in inhibiting pancreatic cancer cell growth in vitro and in vivo.
Combining clinicopathological predictors and molecular biomarkers in the oncogenic K-RAS/Ki67/HIF-1? pathway to predict survival in resectable pancreatic cancer.
Common occurrence of multiple K-RAS mutations in pancreatic cancers with associated precursor lesions and in biliary cancers.
Comparative analysis of mutations in the p53 and K-ras genes in pancreatic cancer.
Comparing the diagnostic accuracy of five common tumour biomarkers and CA19-9 for pancreatic cancer: a protocol for a network meta-analysis of diagnostic test accuracy.
Comparison of K-ras point mutations at codon 12 and p21 expression in pancreatic cancer between Japanese and Chinese patients.
Contribution of epithelial-to-mesenchymal transition and cancer stem cells to pancreatic cancer progression.
Correction: Inhibition of RAC1 GTPase sensitizes pancreatic cancer cells to ?-irradiation.
Correlation Between RAB27B and p53 Expression and Overall Survival in Pancreatic Cancer.
Current treatment strategies for pancreatic cancer in the elderly.
Cyclic AMP regulates the migration and invasion potential of human pancreatic cancer cells.
Cyclin Dependent Kinase 5 is amplified and over-expressed in pancreatic cancer and activated by mutant K-Ras.
Decreased expression of DAB2IP in pancreatic cancer with wild-type KRAS.
Detecting K-ras and p53 gene mutation from stool and pancreatic juice for diagnosis of early pancreatic cancer.
Detection of K-ras gene mutation at codon 12 by pancreatic duct brushing for pancreatic cancer.
Detection of K-ras gene mutation by liquid biopsy in patients with pancreatic cancer.
Detection of K-ras gene mutations at codon 12 in the pancreatic juice of patients with intraductal papillary mucinous tumors of the pancreas.
Detection of K-ras gene mutations in feces by magnetic nanoprobe in patients with pancreatic cancer: A preliminary study.
Detection of K-ras mutations by denaturing gradient gel electrophoresis (DGGE): a study on pancreatic cancer.
Detection of K-ras mutations in pancreatic and hepatic neoplasms by non-isotopic mismatched polymerase chain reaction.
Detection of K-ras mutations in the plasma DNA of pancreatic cancer patients.
Detection of K-ras point mutation and telomerase activity during endoscopic retrograde cholangiopancreatography in diagnosis of pancreatic cancer.
Detection of K-ras point mutation at codon 12 in pure pancreatic juice collected 3 years and 6 months before the clinical diagnosis of pancreatic cancer.
Detection of K-ras point mutation by enriched PCR-colorimetric plate assay.
Detection of K-ras point mutations at codon 12 in pancreatic juice for the diagnosis of pancreatic cancer by hybridization protection assay: a simple method for the determination of the types of point mutation.
Detection of K-ras point mutations at codon 12 in pure pancreatic juice for the diagnosis of pancreatic cancer by PCR-RFLP analysis.
Detection of mutations of p53 tumor suppressor gene in pancreatic juice and its application to diagnosis of patients with pancreatic cancer: comparison with K-ras mutation.
Detection of pancreatic carcinoma: diagnostic value of K-ras mutations in circulating DNA from serum.
Detection of point mutations in K-ras gene at codon 12 in bile from percutaneous transhepatic choledochal drainage tubes for diagnosis of biliary strictures.
Detection of ras gene mutations in perioperative peripheral blood with pancreatic adenocarcinoma.
Development of gene therapy to target pancreatic cancer.
Diagnosis of pancreatic cancer by cytology and measurement of oncogene and tumor markers in pure pancreatic juice aspirated by endoscopy.
Diagnosis of pancreatic cancer by detecting telomerase activity in pancreatic juice: comparison with K-ras mutations.
Diagnosis of pancreatic cancer by K-ras point mutation and cytology of pancreatic juice.
Diagnosis of pancreatico-biliary malignancy: detection of gene mutations in plasma and stool.
Diagnostic utility of K-ras mutations in fine-needle aspirates of pancreatic masses.
Diagnostic value of K-ras mutations in serum of pancreatic cancer patients.
Dietary Garcinol Arrests Pancreatic Cancer in p53 and K-ras Conditional Mutant Mouse Model.
Differential diagnosis of pancreatic cancer and focal pancreatitis by using EUS-guided FNA.
Differential display of expressed genes in pancreatic cancer cells.
Differential high-resolution melting analysis for the detection of K-ras codons 12 and 13 mutations in pancreatic cancer.
Differential role of Interleukin-1 and Interleukin-6 in K-Ras-driven pancreatic carcinoma undergoing mesenchymal transition.
Discovery and characterization of small molecule Rac1 inhibitors.
Disruption of actin filaments and suppression of pancreatic cancer cell viability and migration following treatment with polyisoprenylated cysteinyl amides.
DNA adducts, genetic polymorphisms, and K-ras mutation in human pancreatic cancer.
Doc-2/hDab2 expression is up-regulated in primary pancreatic cancer but reduced in metastasis.
Does detection of K-ras mutations in pancreatic juice influence clinical decision making?
Dominant negative MEKK1 inhibits survival of pancreatic cancer cells.
Down-regulation of the nuclear factor-kappaB by lidamycin in association with inducing apoptosis in human pancreatic cancer cells and inhibiting xenograft growth.
Downregulation of PAR-4, a pro-apoptotic gene, in pancreatic tumors harboring K-ras mutation.
Downregulation of Ral GTPase-activating protein promotes tumor invasion and metastasis of bladder cancer.
Early detection of pancreatic cancer in patients with chronic pancreatitis: diagnostic utility of a K-ras point mutation in the pancreatic juice.
Effective treatment of pancreatic cancer xenografts with a conditionally replicating virus derived from type 2 herpes simplex virus.
Effects of antisense oligonucleotides targeting k-ras expression in pancreatic-cancer cell-lines.
Effects of Rab27A and Rab27B on Invasion, Proliferation, Apoptosis, and Chemoresistance in Human Pancreatic Cancer Cells.
Effects of the antitumor agent perillyl alcohol on H-Ras vs. K-Ras farnesylation and signal transduction in pancreatic cells.
EGFR and HER2 inhibition in pancreatic cancer.
Enhanced therapeutic effects for human pancreatic cancer by application K-ras and IGF-IR antisense oligodeoxynucleotides.
Epidermal Growth Factor Receptor Signaling to the Mitogen Activated Protein Kinase Pathway Bypasses Ras in Pancreatic Cancer Cells.
Epigenetics and pancreatic cancer: pathophysiology and novel treatment aspects.
Establishment and characterization of a new human pancreatic adenocarcinoma cell line with high metastatic potential to the lung.
Evaluation of clinical relevance of examining K-ras, p16 and p53 mutations along with allelic losses at 9p and 18q in EUS-guided fine needle aspiration samples of patients with chronic pancreatitis and pancreatic cancer.
Evaluation of K-ras and p53 expression in pancreatic adenocarcinoma using the cancer genome atlas.
Evaluation of the diagnostic value of serum tumor markers, and fecal k-ras and p53 gene mutations for pancreatic cancer.
Expression of Ki-67, p53, and K-ras in chronic pancreatitis and pancreatic ductal adenocarcinoma.
Expression profiles of pancreatic cancer cell lines infected with antisense K-ras-expressing adenoviral vector.
Extracellular p53 fragment re-enters K-Ras mutated cells through the caveolin-1 dependent early endosomal system.
FAK and interacting proteins as therapeutic targets in pancreatic cancer.
Farnesyltransferase inhibitor (L-744,832) restores TGF-beta type II receptor expression and enhances radiation sensitivity in K-ras mutant pancreatic cancer cell line MIA PaCa-2.
Follow-Up Study of K-ras Mutations in the Plasma of Patients With Pancreatic Cancer: Correlation With Clinical Features and Carbohydrate Antigen 19-9.
Food and nutrient intakes and K-ras mutations in exocrine pancreatic cancer.
Frequent and Significant K-ras Mutation in the Pancreas, the Bile Duct, and the Gallbladder in Autoimmune Pancreatitis.
Frequent deletions of tumor suppressor genes in pure pancreatic juice from patients with tumoral or nontumoral pancreatic diseases.
Frequent RASSF1A promoter hypermethylation and K-ras mutations in pancreatic carcinoma.
Functionalized Graphene@Gold Nanostar/Lipid for Pancreatic Cancer Gene and Photothermal Synergistic Therapy under Photoacoustic/Photothermal Imaging Dual-Modal Guidance.
Gene expression profiling of adenosine triphosphate-binding cassette transporters in response to K-ras activation and hypoxia in human pancreatic cancer cell cultures.
Gene therapy of pancreatic cancer targeting the K-Ras oncogene.
Generalizing molecular results arising from incomplete biological samples: expected bias and unexpected findings.
Genetic alterations in chronic pancreatitis: evidence for early occurrence of p53 but not K-ras mutations.
Genetic alterations in pancreatic carcinoma.
Genetic Alterations of K-ras, p53, c-erbB-2, and DPC4 in Pancreatic Ductal Adenocarcinoma and Their Correlation With Patient Survival.
Genetic basis of pancreatic cancer.
Genetic diagnosis of pancreatic cancer using specimens obtained by EUS-FNA.
Genomic instability and histone H3 phosphorylation induction by the Ras-mitogen activated protein kinase pathway in pancreatic cancer cells.
Graphene-Assisted Electrochemical Sensor for Detection of Pancreatic Cancer Markers.
Growth inhibition of human pancreatic cancer cell lines by anti-sense oligonucleotides specific to mutated K-ras genes.
Hammerhead ribozyme specifically inhibits mutant K-ras mRNA of human pancreatic cancer cells.
Hdm2 is regulated by K-Ras and mediates p53-independent functions in pancreatic cancer cells.
Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis.
High expression of RAB27A and TP53 in pancreatic cancer predicts poor survival.
High expression of RAB38 promotes malignant progression of pancreatic cancer.
High Levels of Cell-Free Circulating Nucleic Acids in Pancreatic Cancer are Associated With Vascular Encasement, Metastasis and Poor Survival.
High proportion of mutant K-ras gene in pancreatic juice of patients with pancreatic cystic lesions.
High yields of K-ras mutations in intraductal papillary mucinous tumors and invasive adenocarcinomas induced by N-nitroso(2-hydroxypropyl)(2-oxopropyl)amine in the pancreas of female Syrian hamsters.
How to Target Activated Ras Proteins: Direct Inhibition vs. Induced Mislocalization.
Hydrogel-microsphere-enhanced surface plasmon resonance for the detection of a K-ras point mutation employing peptide nucleic acid.
Hyperstable U1snRNA complementary to the K-ras transcripts induces cell death in pancreatic cancer cells.
Identification of effective siRNA against K-ras in human pancreatic cancer cell line MiaPaCa-2 by siRNA expression cassette.
Identification of genes showing differential expression in antisense K-ras-transduced pancreatic cancer cells with suppressed tumorigenicity.
Identification of K-ras mutations in pancreatic juice in the early diagnosis of pancreatic cancer.
Identification of K-ras oncogene mutations in the pure pancreatic juice of patients with ductal pancreatic cancers.
Identification of prognostic lipid droplet-associated genes in pancreatic cancer patients via bioinformatics analysis.
In-silico design of peptide inhibitors of K-Ras target in cancer disease.
Inactivation of Ink4a/Arf leads to deregulated expression of miRNAs in K-Ras transgenic mouse model of pancreatic cancer.
Inactivation of Rab23 inhibits the invasion and motility of pancreatic duct adenocarcinoma.
Increased Ras GTPase activity is regulated by miRNAs that can be attenuated by CDF treatment in pancreatic cancer cells.
Increased telomerase activities in human pancreatic duct adenocarcinomas.
Induction of CTLs by DCs pulsed with K-ras mutant peptide on the surface of nanoparticles in the treatment of pancreatic cancer.
Induction of reactive oxygen species renders mutant and wild-type K-ras pancreatic carcinoma cells susceptible to Ad.mda-7-induced apoptosis.
Inhibiting K-ras Signaling Reserves the Epithelial-Mesenchymal Transition of Pancreatic Cancer Cells and its Mechanisms.
Inhibition of growth and invasive activity of human pancreatic cancer cells by a farnesyltransferase inhibitor, manumycin.
Inhibition of human pancreatic cancer cell (MIA PaCa-2) growth by cholera toxin and 8-chloro-cAMP in vitro.
Inhibition of peroxisome proliferator-activated receptor gamma activity suppresses pancreatic cancer cell motility.
Inhibition of RAC1 GTPase sensitizes pancreatic cancer cells to ?-irradiation.
Integrin ?1 promotes gemcitabine resistance in pancreatic cancer through Cdc42 activation of PI3K p110? signaling.
Interferon-alpha and antisense K-ras RNA combination gene therapy against pancreatic cancer.
Interleukin-6 promotes pancreatic cancer cell migration by rapidly activating the small GTPase CDC42.
Intradermal ras peptide vaccination with granulocyte-macrophage colony-stimulating factor as adjuvant: Clinical and immunological responses in patients with pancreatic adenocarcinoma.
Intraductal papillary-mucinous tumours represent a distinct group of pancreatic neoplasms: an investigation of tumour cell differentiation and K-ras, p53 and c-erbB-2 abnormalities in 26 patients.
Intraperitoneal injection of adenovirus expressing antisense K-ras RNA suppresses peritoneal dissemination of hamster syngeneic pancreatic cancer without systemic toxicity.
Invasive ductal adenocarcinoma of the remnant pancreatic body 9 years after resection of an intraductal papillary-mucinous carcinoma of the pancreatic head: a case report and comparison of DNA sequence in K-ras gene mutation.
Involvement of oncogenic K-ras on cell migration stimulated by lysophosphatidic acid receptor-2 in pancreatic cancer cells.
IQGAP1 selectively interacts with K-Ras but not with H-Ras and modulates K-Ras function.
Isolation of a chemical inhibitor against K-Ras-induced p53 suppression through natural compound screening.
Isoprenoids responsible for protein prenylation modulate the biological effects of statins on pancreatic cancer cells.
K-ras and p53 gene mutations in pancreatic cancer: ductal and nonductal tumors progress through different genetic lesions.
K-ras and p53 in pancreatic cancer: association with medical history, histopathology, and environmental exposures in a population-based study.
K-ras as a genetic marker in pancreatic cancer.
K-ras gene mutations in the diagnosis of fine-needle aspirates of pancreatic masses: prospective study using two techniques with different detection limits.
K-RAS Mutant Pancreatic Tumors Show Higher Sensitivity to MEK than to PI3K Inhibition In Vivo.
K-ras mutation and p16 and preproenkephalin promoter hypermethylation in plasma DNA of pancreatic cancer patients: in relation to cigarette smoking.
K-Ras mutation detection in liquid biopsy and tumor tissue as prognostic biomarker in patients with pancreatic cancer: a systematic review with meta-analysis.
K-Ras mutation in liquid biopsy and tumor tissue correlation in patients with pancreatic cancer.
K-ras mutation: early detection in molecular diagnosis and risk assessment of colorectal, pancreas, and lung cancers--a review.
K-ras mutational status in cytohistological tissue as a molecular marker for the diagnosis of pancreatic cancer: a systematic review and meta-analysis.
K-ras mutational status predicts poor prognosis in unresectable pancreatic cancer.
K-ras mutations and allelic loss at 5q and 18q in the development of human pancreatic cancers.
K-ras mutations at codon 12 are rare events in chronic pancreatitis.
K-ras mutations in canine pancreatic cancers.
K-ras Mutations in the Plasma Correspond to Computed Tomographic Findings in Patients With Pancreatic Cancer.
K-ras mutations in tissue and stool samples from patients with pancreatic cancer and chronic pancreatitis.
K-ras oncogene silencing strategy reduces tumor growth and enhances gemcitabine chemotherapy efficacy for pancreatic cancer treatment.
K-Ras promotes angiogenesis mediated by immortalized human pancreatic epithelial cells through mitogen-activated protein kinase signaling pathways.
K-Ras Promotes Tumorigenicity through Suppression of Non-canonical Wnt Signaling.
K-Ras-driven pancreatic cancer mouse model for anticancer inhibitor analyses.
K-Ras-independent effects of the farnesyl transferase inhibitor L-744,832 on cyclin B1/Cdc2 kinase activity, G2/M cell cycle progression and apoptosis in human pancreatic ductal adenocarcinoma cells.
Keap1-Nrf2 signalling in pancreatic cancer.
Killer genes in pancreatic cancer therapy.
Lack of elevated MAP kinase (Erk) activity in pancreatic carcinomas despite oncogenic K-ras expression.
Lifetime history of tobacco consumption and K-ras mutations in exocrine pancreatic cancer.
Lin28-let7 modulates radiosensitivity of human cancer cells with activation of K-Ras.
Liposome-mediated in vivo gene transfer of antisense K-ras construct inhibits pancreatic tumor dissemination in the murine peritoneal cavity.
Long noncoding RNA LINC00514 accelerates pancreatic cancer progression by acting as a ceRNA of miR-28-5p to upregulate Rap1b expression.
Long-term follow-up of chronic pancreatitis patients with K-ras mutation in the pancreatic juice.
Long-term follow-up of patients with chronic pancreatitis and K-ras gene mutation detected in pancreatic juice.
Long-term follow-up of patients with resected pancreatic cancer following vaccination against mutant K-ras.
Lovastatin inhibits pancreatic cancer growth regardless of RAS mutation.
Lovastatin inhibits proliferation of pancreatic cancer cell lines with mutant as well as with wild-type K-ras oncogene but has different effects on protein phosphorylation and induction of apoptosis.
Low correspondence between K-ras mutations in pancreatic cancer tissue and detection of K-ras mutations in circulating DNA.
ME-PCR for the identification of mutated K-ras in serum and bile of pancreatic cancer patients: an unsatisfactory technique for clinical applications.
Metabolic profiling of gemcitabine- and paclitaxel-treated immortalized human pancreatic cell lines with K-RAS
Metabolic regulation of EGFR effector and feedback signaling in pancreatic cancer cells requires K-Ras.
Micro-RNA-155 is induced by K-Ras oncogenic signal and promotes ROS stress in pancreatic cancer.
MicroRNA regulation of K-Ras in pancreatic cancer and opportunities for therapeutic intervention.
miR-137 Modulates a Tumor Suppressor Network-Inducing Senescence in Pancreatic Cancer Cells.
miR-142-5p regulates pancreatic cancer cell proliferation and apoptosis by regulation of RAP1A.
miR?448 targets Rab2B and is pivotal in the suppression of pancreatic cancer.
Modified radiosensitivity of pancreatic cancer xenografts by farnesyl protein transferase inhibitor and MEK inhibitor.
Molecular alterations associated with improved survival in pancreatic cancer patients treated with radiation or chemotherapy.
Molecular beacon imaging of tumor marker gene expression in pancreatic cancer cells.
Molecular biology of pancreatic cancer: potential clinical implications.
Molecular biology of pancreatic cancer; oncogenes, tumour suppressor genes, growth factors, and their receptors from a clinical perspective.
Molecular consequences of silencing mutant K-ras in pancreatic cancer cells: justification for K-ras-directed therapy.
Molecular diagnosis of early pancreatic ductal adenocarcinoma in high-risk patients.
Molecular diagnosis of exocrine pancreatic cancer using a percutaneous technique.
Molecular diagnosis of pancreas carcinoma.
Molecular diagnosis of pancreatic cancer.
Molecular epidemiology of pancreatic cancer.
Molecular genetics and related developments in pancreatic cancer.
Molecular markers for diagnostic cytology of neoplasms in the head region of the pancreas: mutation of K-ras and overexpression of the p53 protein product.
Molecular oncology in pancreatic cancer.
Molecular pathogenesis of pancreatic adenocarcinoma: Potential clinical implications.
Molecular pathogenesis of pancreatic cancer and clinical perspectives.
Molecular target-based therapy of pancreatic cancer.
Molecular versus conventional markers in pancreatic cancer.
Molecular-based and alternative therapies for pancreatic cancer: looking "out of the box".
Multi-step pancreatic carcinogenesis and its clinical implications.
Multiplexed Real-Time NMR GTPase Assay for Simultaneous Monitoring of Multiple Guanine Nucleotide Exchange Factor Activities from Human Cancer Cells and Organoids.
Mutant K-Ras increases GSK-3? gene expression via an ETS-p300 transcriptional complex in pancreatic cancer.
Mutant K-RAS Promotes Invasion and Metastasis in Pancreatic Cancer Through GTPase Signaling Pathways.
Mutated K-ras activates CDK8 to stimulate the epithelial-to-mesenchymal transition in pancreatic cancer in part via the Wnt/?-catenin signaling pathway.
Mutation Status of K-ras, p53 and Allelic Losses at 9p and 18q Are Not Prognostic Markers in Patients with Pancreatic Cancer.
Mutations in K-Ras linked to levels of osteoprotegerin and sensitivity to TRAIL-induced cell death in pancreatic ductal adenocarcinoma cells.
MUTYH exon 7 and 13 mutations associated with colorectal cancer (MAP syndrome) are not commonly associated with sporadic pancreatic cancer.
Nanoformulation of Geranylgeranyltransferase-I Inhibitors for Cancer Therapy: Liposomal Encapsulation and pH-Dependent Delivery to Cancer Cells.
Nanoparticle delivery of an AKT/PDK1 inhibitor improves the therapeutic effect in pancreatic cancer.
Naturally Occurring T-Cell Response against Mutated p21 Ras Oncoprotein in Pancreatic Cancer.
Notch1 functions as a tumor suppressor in a model of K-ras-induced pancreatic ductal adenocarcinoma.
Novel mechanism of MDA-7/IL-24 cancer-specific apoptosis through SARI induction.
Novel synthetic oleanane triterpenoid AMR-MeOAc inhibits K-Ras through ERK, Akt and survivin in pancreatic cancer cells.
Nrf2 Activation Sensitizes K-Ras Mutant Pancreatic Cancer Cells to Glutaminase Inhibition.
Occupational exposure to dyes, metals, polycyclic aromatic hydrocarbons and other agents and K-ras activation in human exocrine pancreatic cancer.
Occupational exposure to organic solvents and K-ras mutations in exocrine pancreatic cancer.
Oligonucleotide treatment of ras-induced tumors in nude mice.
Oncogenic K-ras Induces Mitochondrial OPA3 Expression to Promote Energy Metabolism in Pancreatic Cancer Cells.
Oncolytic viral therapy for human pancreatic cancer cells by reovirus.
Overexpression and biological function of IQGAP3 in human pancreatic cancer.
p16 and K-ras gene mutations in the intraductal precursors of human pancreatic adenocarcinoma.
p8 expression controls pancreatic cancer cell migration, invasion, adhesion and tumorigenesis.
Pancreatic adenocarcinoma: epidemiology and genetics.
Pancreatic cancer after remote peptic ulcer surgery.
Pancreatic cancer cell radiation survival and prenyltransferase inhibition: the role of K-Ras.
Pancreatic cancer in patients with pancreatic cystic lesions: a prospective study in 197 patients.
Pancreatic cancer inhibition by specific knockdown of K-ras mutant allele expression.
Pathogenesis of colorectal carcinoma and therapeutic implications: the roles of the ubiquitin-proteasome system and Cox-2.
Patterns of genetic alterations in pancreatic cancer: a pooled analysis.
Periodontal Pathogens in the Etiology of Pancreatic Cancer.
Peritoneal washing cytology combined with immunocytochemical staining and detecting mutant K-ras in pancreatic cancer: comparison of the sensitivity and availability of various methods.
Peroxisome proliferator-activated receptor gamma and regulations by the ubiquitin-proteasome system in pancreatic cancer.
Phytohemagglutinin-L (PHA-L) lectin surface binding of N-linked beta 1-6 carbohydrate and its relationship to activated mutant ras in human pancreatic cancer cell lines.
Polymerase chain reaction-based K-ras mutation detection of pancreatic adenocarcinoma in routine cytology smears.
Preconditioning of the tumor microenvironment with oncolytic reovirus converts CD3-bispecific antibody treatment into effective immunotherapy.
Predictive factors for pancreatic cancer in patients with chronic pancreatitis in association with K-ras gene mutation.
Predictive signatures inform the effective repurposing of Decitabine to treat K-RAS-dependent Pancreatic Ductal Adenocarcinoma.
Prevalence and clinical significance of combined K-ras mutation and p53 aberration in pancreatic adenocarcinoma.
Prognostic significance of K-ras mutations in pancreatic cancer: a meta-analysis.
Prognostic value of K-ras mutation status and subtypes in endoscopic ultrasound-guided fine-needle aspiration specimens from patients with unresectable pancreatic cancer.
Promoting effect of a high-fat/high-protein diet in DMBA-induced ductal pancreatic cancer in rats.
Prospective evaluation of the contribution of K-ras mutational analysis and CA 19.9 measurement to cytological diagnosis in patients with clinical suspicion of pancreatic cancer.
Quantitative determination of K-ras mutations in pancreatic juice for diagnosis of pancreatic cancer using hybridization protection assay.
Quantity of mutant K-ras gene in pancreatic secretions for diagnosis of pancreatic carcinoma with different assays: analysis of 100 patients.
Rab27a plays a dual role in metastatic propensity of pancreatic cancer.
RAB5A promotes the formation of filopodia in pancreatic cancer cells via the activation of cdc42 and ?1-integrin.
Rac1 GTPase in pancreatic cancer.
Radiosensitization effect of STI-571 on pancreatic cancer cells in vitro.
Radiosensitization of epidermal growth factor receptor/HER2-positive pancreatic cancer is mediated by inhibition of Akt independent of ras mutational status.
Radiosensitizing Effects of the Prenyltransferase Inhibitor AZD3409 against RAS Mutated Cell Lines.
Rapid and Sensitive Assay of K-ras Mutations in Pancreatic Cancer by Electrochemical Detection with Ferrocenyl-naphthalene-diimide.
ras and human tumors.
Ras mutation, irrespective of cell type and p53 status, determines a cell's destiny to undergo apoptosis by okadaic acid, an inhibitor of protein phosphatase 1 and 2A.
Rasfonin, a novel 2-pyrone derivative, induces ras-mutated Panc-1 pancreatic tumor cell death in nude mice.
Reassessment of K-ras mutations at codon 12 by direct PCR and sequencing from tissue microdissection in human pancreatic adenocarcinomas.
Recent progress and limitations of chemotherapy for pancreatic and biliary tract cancers.
Recombinant expression of different mutant K-ras gene in pancreatic cancer Bxpc-3 cells and its effects on chemotherapy sensitivity.
Regulation of CD137 expression through K-Ras signaling in pancreatic cancer cells.
Regulation of pancreatic cancer growth by superoxide.
Relationship between K-ras mutation and the expression of p21WAF1/CIP1 and p53 in chronic pancreatitis and pancreatic adenocarcinoma.
Relationship of family cancer history to the expression of p53, p21WAF-1, HER-2/neu, and K-ras mutation in pancreatic adenocarcinoma.
Remote partial gastrectomy as a risk factor for pancreatic cancer: potential for preventive strategies.
Retraction notice to "Increased Ras GTPase activity is regulated by miRNAs that can be attenuated by CDF treatment in pancreatic cancer cells" [Cancer Lett. 319(2) (2012) 173-181].
Retraction: "Activated K-Ras and INK4a/Arf Deficiency Promote Aggressiveness of Pancreatic Cancer by Induction of EMT Consistent With Cancer Stem Cell Phenotype" by Wang et al.
Retraction: "Inactivation of Ink4a/Arf Leads to Deregulated Expression of miRNAs in K-Ras Transgenic Mouse Model of Pancreatic Cancer" by Ali et al.
Retraction: Activated K-ras and INK4a/Arf Deficiency Cooperate During the Development of Pancreatic Cancer by Activation of Notch and NF-?B Signaling Pathways.
Ribozyme against mutant K-ras mRNA suppresses tumor growth of pancreatic cancer.
RInhibiting K-ras Signaling Reserves the Epithelial-Mesenchymal Transition of Pancreatic Cancer Cells and its Mechanisms.
Role of Rac1-dependent NADPH oxidase in the growth of pancreatic cancer.
Role of RAF/MEK/ERK pathway, p-STAT-3 and Mcl-1 in sorafenib activity in human pancreatic cancer cell lines.
Role of tumor markers and mutations in cells and pancreatic juice in the diagnosis of pancreatic cancer.
Role of tumour markers, cytogenetics.
Salirasib in the treatment of pancreatic cancer.
Senescence in pancreatic carcinogenesis: from signalling to chromatin remodelling and epigenetics.
Sensitization of Human Pancreatic Cancer Cells Harboring Mutated K-ras to Apoptosis.
Serum concentrations of organochlorine compounds and K-ras mutations in exocrine pancreatic cancer. PANKRAS II Study Group.
Signal therapy of human pancreatic cancer and NF1-deficient breast cancer xenograft in mice by a combination of PP1 and GL-2003, anti-PAK1 drugs (Tyr-kinase inhibitors).
Significance of K-ras mutation and CEA level in pancreatic juice in the diagnosis of pancreatic cancer.
Simple and sensitive detection of K-ras gene mutations in human pancreatic cancers by nonradioisotopic single-strand conformation polymorphism analysis.
SiRNA Delivery with PEGylated Graphene Oxide Nanosheets for Combined Photothermal and Genetherapy for Pancreatic Cancer.
SKA1 regulates actin cytoskeleton remodelling via activating Cdc42 and influences the migration of pancreatic ductal adenocarcinoma cells.
Statins and pancreatic cancer.
Stool testing for the early detection of pancreatic cancer: rationale and current evidence.
Sulforaphane, quercetin and catechins complement each other in elimination of advanced pancreatic cancer by miR-let-7 induction and K-ras inhibition.
Superoxide Dismutases in Pancreatic Cancer.
Suppression of colorectal cancer growth using an adenovirus vector expressing an antisense K-ras RNA.
Suppression of invasion of a hamster pancreatic cancer cell line by antisense oligonucleotides mutation-matched to K-ras gene.
Suppression of pancreatic cancer by the dominant negative ras mutant, N116Y.
Suppression of PKC causes oncogenic stress for triggering apoptosis in cancer cells.
Survival regulation in pancreatic cancer cells by c-Jun.
Syndecan-2 promotes perineural invasion and cooperates with K-ras to induce an invasive pancreatic cancer cell phenotype.
Synergistic antitumor effects of radiation and proteasome inhibitor treatment in pancreatic cancer through the induction of autophagy and the downregulation of TRAF6.
Synthesis, molecular characterization, and biological activity of novel synthetic derivatives of chromen-4-one in human cancer cells.
Synthetic 8-hydroxydeoxyguanosine inhibited metastasis of pancreatic cancer through concerted inhibitions of ERM and Rho-GTPase.
Targeting EphA2 with miR-124 mediates Erlotinib resistance in K-RAS mutated pancreatic cancer.
Targeting KRAS for diagnosis, prognosis, and treatment of pancreatic cancer: Hopes and realities.
Targeting Mutated K-ras in Pancreatic Adenocarcinoma Using an Adjuvant Vaccine.
Targeting Pancreatic Cancer Metastasis by Inhibition of Vav1, a Driver of Tumor Cell Invasion.
Targeting the K-Ras--JNK axis eliminates cancer stem-like cells and prevents pancreatic tumor formation.
Telomerase activity in pure pancreatic juice for the diagnosis of pancreatic cancer may be complementary to K-ras mutation.
The Association Between Selected Risk Factors for Pancreatic Cancer and the Expression of p53 and K-ras Codon 12 Mutations.
The dominant negative H-ras mutant, N116Y, suppresses growth of metastatic human pancreatic cancer cells in the liver of nude mice.
The molecular genetics of pancreatic cancer.
The mucin MUC4 is a transcriptional and post-transcriptional target of K-ras oncogene in pancreatic cancer. Implication of MAPK/AP-1, NF-?B and RalB signaling pathways.
The nuclear factor-kappa B RelA transcription factor is constitutively activated in human pancreatic adenocarcinoma cells.
The plasminogen activator system in pancreas cancer: role of t-PA in the invasive potential in vitro.
The Ras inhibitor farnesylthiosalicylic acid (Salirasib) disrupts the spatiotemporal localization of active Ras: a potential treatment for cancer.
The Ras inhibitor S-trans,trans-farnesylthiosalicylic acid chemosensitizes human tumor cells without causing resistance.
The RAS-RAL axis in cancer: evidence for mutation-specific selectivity in non-small cell lung cancer.
The Ratio of RAC1B to RAC1 Expression in Breast Cancer Cell Lines as a Determinant of Epithelial/Mesenchymal Differentiation and Migratory Potential.
The regulatory roles of miRNA and methylation on oncogene and tumor suppressor gene expression in pancreatic cancer cells.
The relative influence of diet and serum concentrations of organochlorine compounds on K-ras mutations in exocrine pancreatic cancer.
The role of manganese superoxide dismutase in the growth of pancreatic adenocarcinoma.
The Significance of p53 and K-ras Immunocytochemical Staining in the Diagnosis of Malignant Biliary Obstruction by Brush Cytology during ERCP.
The Significance of Ras Activity in Pancreatic Cancer Initiation.
The survival kinase Mirk/Dyrk1B is a downstream effector of oncogenic K-ras in pancreatic cancer.
The therapeutic effect of cytokine-induced killer cells on pancreatic cancer enhanced by dendritic cells pulsed with k-ras mutant Peptide.
Therapeutic effect of c-Jun N-terminal kinase inhibition on pancreatic cancer.
Therapy for regionally unresectable pancreatic cancer.
Tissue Transglutaminase (TG2)-Induced Inflammation in Initiation, Progression, and Pathogenesis of Pancreatic Cancer.
TOB1 suppresses proliferation in K-Ras wild-type pancreatic cancer.
Toll-like receptor 9 agonist IMO cooperates with cetuximab in K-ras mutant colorectal and pancreatic cancers.
Translating discovery in zebrafish pancreatic development to human pancreatic cancer: biomarkers, targets, pathogenesis, and therapeutics.
Transrenal DNA as a diagnostic tool: important technical notes.
Treatment of pancreatic cancer: current limitations, future possibilities.
TrkBT1 induces liver metastasis of pancreatic cancer cells by sequestering Rho GDP dissociation inhibitor and promoting RhoA activation.
Tumor suppressor p16INK4a controls oncogenic K-Ras function in human pancreatic cancer cells.
Twenty-one proteins up-regulated in human H-ras oncogene transgenic rat pancreas cancers are up-regulated in human pancreas cancer.
Unfavourable prognosis associated with K-ras gene mutation in pancreatic cancer surgical margins.
Unique GGT --> GTT mutation at K-ras codon 12 in six human pancreatic cancer cell lines from Chinese patients.
Up-regulation of MSX2 enhances the malignant phenotype and is associated with twist 1 expression in human pancreatic cancer cells.
Use of herbal medicines and natural products: an alternative approach to overcoming the apoptotic resistance of pancreatic cancer.
Usefulness of K-ras gene mutation at codon 12 in bile for diagnosing biliary strictures.
Validation of blood testing for K-ras mutations in colorectal and pancreatic cancer.
Values of mutations of K-ras oncogene at codon 12 in detection of pancreatic cancer: 15-year experience.
ZIP4 Promotes Muscle Wasting and Cachexia in Mice With Orthotopic Pancreatic Tumors by Stimulating RAB27B-Regulated Release of Extracellular Vesicles From Cancer Cells.
[An application value of detecting K-ras and p53 gene mutation in the stool and pure pancreatic juice for diagnosis of early pancreatic cancer]
[Anti-pancreatic cancer immune response induced by K-ras mutated peptide]
[Clinical significance of K-RAS and cytokeratine 20 markers in diagnosis of lymphogenic metastasis of pancreatic cancer]
[Combinational effects of K-ras and IGF-IR antisense oligodeoxynucleotide on proliferation and apoptosis of human pancreatic cancer Patu8988 cells]
[Combined detection of K-ras mutation and CA19-9 level in plasma of patients with pancreatic cancer]
[Detection of hepatic micrometastasis in ductal pancreatic carcinoma by K-ras mutation analysis and determination of clinical relevance]
[Detection of K-ras gene mutations in DNA extracted from the plasma of patients with pancreatic cancer]
[Detection of point mutation of Kirsten ras oncogene in pancreatic carcinoma by polymerase chain reaction]
[Detection of ras gene mutations of pancreatic tumors by polymerase chain reaction and direct sequencing method]
[Developing a hospital-based high risk scoring model and screening strategy for pancreatic cancer]
[Experiment study on the diagnostic value of bile K-ras gene mutation responsible to the hepatic metastasis of pancreatic cancer]
[K-ras gene mutation in gallbladder carcinoma]
[K-ras mutation in pancreatic juice from patients with pancreatic carcinoma]
[K-ras mutations detection in paraaortic lymph nodes and its prognostic value after the surgical treatment of pancreas cancer]
[Molecular diagnosis in pancreatic carcinoma]
[Molecular diagnosis of pancreatic cancer]
[New molecular targets in pancreatic cancer]
[Pancreatic cancer]
[Pancreatic carcinogenesis. Clinical implications]
[Recent advances in gene change of pancreatic cancer]
[Sensitivity and specificity of tumor markers in cancer diagnosis]
[Specific immune against pancreatic cancer induced by dendritic cells pulsed with mutant K-ras peptide]
[The diagnostic value of serum carcinoma markers, fecal K-ras and p53 gene mutation in pancreatic cancers]
Pancreaticobiliary Maljunction
DPC-4 (Smad-4) and K-ras gene mutations in biliary tract epithelium in children with anomalous pancreaticobiliary ductal union.
K-ras and p53 gene mutations in noncancerous biliary lesions of patients with pancreaticobiliary maljunction.
K-ras point mutations in cancerous and noncancerous biliary epithelium in patients with pancreaticobiliary maljunction.
Proliferative potential and K-ras mutation in epithelial hyperplasia of the gallbladder in patients with anomalous pancreaticobiliary ductal union.
Relation between K-ras codon 12 mutation and p53 protein overexpression in gallbladder cancer and biliary ductal epithelia in patients with pancreaticobiliary maljunction.
Pancreatitis
An integrated approach for comparative proteomic analysis of human bile reveals overexpressed cancer-associated proteins in malignant biliary stenosis.
Autophagy in pancreatic cancer pathogenesis and treatment.
Different amounts of K-ras mutant epithelial cells in pancreatic carcinoma and mass-forming pancreatitis.
Differential diagnosis of pancreatic cancer and focal pancreatitis by using EUS-guided FNA.
Disruption of Small GTPase Rab7 Exacerbates the Severity of Acute Pancreatitis in Experimental Mouse Models.
Follow-Up Study of K-ras Mutations in the Plasma of Patients With Pancreatic Cancer: Correlation With Clinical Features and Carbohydrate Antigen 19-9.
Frequent RASSF1A promoter hypermethylation and K-ras mutations in pancreatic carcinoma.
Genetic diagnosis of pancreatic cancer using specimens obtained by EUS-FNA.
K-ras and Dpc4 mutations in chronic pancreatitis: case series.
Microsatellite instability and K-ras mutations associated with pancreatic adenocarcinoma and pancreatitis.
Molecular analysis to detect pancreatic ductal adenocarcinoma in high-risk groups.
p53 and K-ras mutations in pancreatic juice samples from patients with chronic pancreatitis.
Pancreatitis-induced inflammation contributes to pancreatic cancer by inhibiting oncogene-induced senescence.
Past medical conditions and K-ras mutations in pancreatic ductal adenocarcinoma: a hypothesis-generating study.
Phenotypic changes in mouse pancreatic stellate cell Ca2+ signaling events following activation in culture and in a disease model of pancreatitis.
Rab GTPase 21 mediates caerulin-induced TRAF3-MKK3-p38 activation and acute pancreatitis response.
Values of mutations of K-ras oncogene at codon 12 in detection of pancreatic cancer: 15-year experience.
Pancreatitis, Alcoholic
Frequent and Significant K-ras Mutation in the Pancreas, the Bile Duct, and the Gallbladder in Autoimmune Pancreatitis.
Pancreatitis, Chronic
A case of small pancreatic cancer diagnosed by serial follow-up studies promptly by a positive K-ras point mutation in pure pancreatic juice.
Absence of K-ras mutations in the pancreatic parenchyma of patients with chronic pancreatitis.
Analysis of K-ras codon 12 point mutations using duodenal lavage fluid for diagnosis of pancreatic carcinoma.
Analysis of K-ras gene mutation in hyperplastic duct cells of the pancreas without pancreatic disease.
Analysis of K-ras mutations in pancreatic tissue after fine needle aspirates.
Analysis of K-ras oncogene mutations in chronic pancreatitis with ductal hyperplasia.
Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinoma by K-Ras oncogenes in adult mice.
Clinical significance of K-ras and c-erbB-2 mutations in pancreatic adenocarcinoma and chronic pancreatitis.
Clinical usefulness of K-ras gene mutation detection and cytology in pancreatic juice in the diagnosis and screening of pancreatic cancer.
Detecting K-ras and p53 gene mutation from stool and pancreatic juice for diagnosis of early pancreatic cancer.
Detection of K-ras gene mutation at codon 12 by pancreatic duct brushing for pancreatic cancer.
Detection of K-ras gene mutations at codon 12 in the pancreatic juice of patients with intraductal papillary mucinous tumors of the pancreas.
Detection of K-ras mutations in the stool of patients with pancreatic adenocarcinoma and pancreatic ductal hyperplasia.
Detection of K-ras point mutation and telomerase activity during endoscopic retrograde cholangiopancreatography in diagnosis of pancreatic cancer.
Detection of K-ras point mutation at codon 12 in pancreatic diseases: a study in a Brazilian casuistic.
Detection of p53 gene mutations in the supernatant of pancreatic juice and plasma from patients with pancreatic carcinomas.
Detection of pancreatic carcinoma: diagnostic value of K-ras mutations in circulating DNA from serum.
Detection of point mutation in K-ras oncogene at codon 12 in pancreatic diseases.
Detection of point mutations in the K-ras oncogene at codon 12 in pure pancreatic juice for diagnosis of pancreatic carcinoma.
Diagnosis of pancreatic cancer by cytology and measurement of oncogene and tumor markers in pure pancreatic juice aspirated by endoscopy.
Diagnosis of pancreatic cancer by detecting telomerase activity in pancreatic juice: comparison with K-ras mutations.
Diagnosis of pancreatic cancer by K-ras point mutation and cytology of pancreatic juice.
Diagnosis of pancreatico-biliary malignancy: detection of gene mutations in plasma and stool.
Ductal lesions in patients with chronic pancreatitis show K-ras mutations in a frequency similar to that in the normal pancreas and lack nuclear immunoreactivity for p53.
Early detection of pancreatic cancer in patients with chronic pancreatitis: diagnostic utility of a K-ras point mutation in the pancreatic juice.
Evaluation of clinical relevance of examining K-ras, p16 and p53 mutations along with allelic losses at 9p and 18q in EUS-guided fine needle aspiration samples of patients with chronic pancreatitis and pancreatic cancer.
Expression of Ki-67, p53, and K-ras in chronic pancreatitis and pancreatic ductal adenocarcinoma.
Frequency of K-ras mutations in pancreatic intraductal neoplasias associated with pancreatic ductal adenocarcinoma and chronic pancreatitis: a meta-analysis.
Frequent deletions of tumor suppressor genes in pure pancreatic juice from patients with tumoral or nontumoral pancreatic diseases.
Genetic alterations in chronic pancreatitis: evidence for early occurrence of p53 but not K-ras mutations.
K-ras and Dpc4 mutations in chronic pancreatitis: case series.
K-ras mutations at codon 12 are rare events in chronic pancreatitis.
K-ras mutations in DNA extracted from the plasma of patients with pancreatic carcinoma: diagnostic utility and prognostic significance.
K-ras mutations in stools and tissue samples from patients with malignant and nonmalignant pancreatic diseases.
K-ras mutations in tissue and stool samples from patients with pancreatic cancer and chronic pancreatitis.
K-ras point mutations in the supernatants of pancreatic juice and bile are reliable for diagnosis of pancreas and biliary tract carcinomas complementary to cytologic examination.
Long-term follow-up of chronic pancreatitis patients with K-ras mutation in the pancreatic juice.
Long-term follow-up of patients with chronic pancreatitis and K-ras gene mutation detected in pancreatic juice.
Molecular analysis to detect pancreatic ductal adenocarcinoma in high-risk groups.
Molecular diagnosis of early pancreatic ductal adenocarcinoma in high-risk patients.
Multi-step pancreatic carcinogenesis and its clinical implications.
Multiple K-ras mutations in hyperplasia and carcinoma in cases of human pancreatic carcinoma.
p53 and K-ras mutations in pancreatic juice samples from patients with chronic pancreatitis.
Predictive factors for pancreatic cancer in patients with chronic pancreatitis in association with K-ras gene mutation.
Relationship between K-ras mutation and the expression of p21WAF1/CIP1 and p53 in chronic pancreatitis and pancreatic adenocarcinoma.
Serum tumor markers and molecular biological diagnosis in pancreatic cancer.
Significance of K-ras codon 12 point mutation in pancreatic juice in the diagnosis of carcinoma of the pancreas.
Spirits and gastrectomy increase risk for chronic pancreatitis in Japanese male alcoholics.
Telomerase activity in pure pancreatic juice for the diagnosis of pancreatic cancer may be complementary to K-ras mutation.
The role of manganese superoxide dismutase in the growth of pancreatic adenocarcinoma.
The role of p21ras in pancreatic neoplasia and chronic pancreatitis.
Tumor angiogenesis in chronic pancreatitis and pancreatic adenocarcinoma: impact of K-ras mutations.
Usufuleness of p16 and K-ras mutation in pancreatic adenocarcinoma and chronic pancreatitis differential diagnosis.
Values of mutations of K-ras oncogene at codon 12 in detection of pancreatic cancer: 15-year experience.
[An application value of detecting K-ras and p53 gene mutation in the stool and pure pancreatic juice for diagnosis of early pancreatic cancer]
[Combined detection of K-ras mutation and CA19-9 level in plasma of patients with pancreatic cancer]
[Detection of hepatic micrometastasis in ductal pancreatic carcinoma by K-ras mutation analysis and determination of clinical relevance]
[K-ras mutation in pancreatic juice from patients with pancreatic carcinoma]
[Molecular diagnosis in pancreatic carcinoma]
[Molecular diagnosis of pancreatic cancer]
[Mutation of the K-ras oncogene in pancreatic carcinoma, and application of its detection in pancreatic juice to diagnose pancreatic carcinoma]
Pancytopenia
Pancytopenia, Recurrent Infection, Poor Wound Healing, Heterotopia of the Brain Probably Associated with A Candidate Novel de Novo CDC42 Gene Defect: Expanding the Molecular and Phenotypic Spectrum.
Papilloma
"Low-risk" and "high-risk" HPV-infection and K-ras gene point mutations in human cervical cancer: a study of 31 cases.
Acute sensitivity of the oral mucosa to oncogenic K-ras.
Antisera to the variable region of ras oncogene proteins, and specific detection of H-ras expression in an experimental model of chemical carcinogenesis.
Association between activated K-ras and c-erbB-2 oncogenes with "high-risk" and "low-risk" human papilloma virus types in preinvasive cervical lesions.
Biliary papillomatosis with the point mutation of K-ras gene arising in congenital choledochal cyst.
Both (+/-)syn- and (+/-)anti-7,12-dimethylbenz[a]anthracene-3,4-diol-1,2-epoxides initiate tumors in mouse skin that possess -CAA- to -CTA- mutations at Codon 61 of c-H-ras.
Comparison of ras activation during epidermal carcinogenesis in vitro and in vivo.
Crosstalk between Pten and Ras signaling pathways in tumor development.
Decreased focal adhesion kinase suppresses papilloma formation during experimental mouse skin carcinogenesis.
Detection of dibenzo[a,l]pyrene-induced H-ras codon 61 mutant genes in preneoplastic SENCAR mouse skin using a new PCR-RFLP method.
Detection of human papilloma virus (HPV) and K-ras mutations in human lung carcinomas.
Evidence that error-prone DNA repair converts dibenzo[a,l]pyrene-induced depurinating lesions into mutations: formation, clonal proliferation and regression of initiated cells carrying H-ras oncogene mutations in early preneoplasia.
Expression of intermediate filament proteins by normal and transformed mouse epidermal-keratinocytes in culture.
H-ras mutations at codon 61 or 13 in tumors initiated with a NO donor in mouse skin.
Haploinsufficiency of the cdc2l gene contributes to skin cancer development in mice.
High frequency of ras mutations in forestomach and lung tumors of B6C3F1 mice exposed to 1-amino-2,4-dibromoanthraquinone for 2 years.
Incidence of Harvey ras oncogene point mutations and their expression in methylbenzylnitrosamine-induced esophageal tumorigenesis.
Increased incidence of squamous cell carcinomas in Mastomys natalensis papillomavirus E6 transgenic mice during two-stage skin carcinogenesis.
K-Ras and ?-catenin mutations cooperate with Fgfr3 mutations in mice to promote tumorigenesis in the skin and lung, but not in the bladder.
K-Ras mediated murine epidermal tumorigenesis is dependent upon and associated with elevated Rac1 activity.
Local cytokine treatment of HPV16-associated tumours results in inhibition of their lung metastases.
Loss of growth control by TGF-beta occurs at a late stage of mouse skin carcinogenesis and is independent of ras gene activation.
Management of two cases of recurrent anal carcinoma.
Molecular abnormalities associated with endocrine tumors of the uterine cervix.
Pak1 and Pak2 are activated in recurrent respiratory papillomas, contributing to one pathway of Rac1-mediated COX-2 expression.
Reduction in IkappaB kinase alpha expression promotes the development of skin papillomas and carcinomas.
Targeted deletion of the H-ras gene decreases tumor formation in mouse skin carcinogenesis.
The neurofibromatosis type 1 (Nf1) tumor suppressor is a modifier of carcinogen-induced pigmentation and papilloma formation in C57BL/6 mice.
The prostaglandin receptor EP2 activates multiple signaling pathways and beta-arrestin1 complex formation during mouse skin papilloma development.
The role of polycyclic aromatic hydrocarbon-DNA adducts in inducing mutations in mouse skin.
The utility of the K6/ODC transgenic mouse as an alternative short term dermal model for carcinogenicity testing of pharmaceuticals.
Transgenic mice provide genetic evidence that transforming growth factor alpha promotes skin tumorigenesis via H-ras-dependent and H-ras-independent pathways.
Papilloma, Intraductal
New Variations in the Promoter Regions of Human DOCK4 and RAP1A Genes, and Coding Regions of RAP1A in Sporadic Breast Tumors.
Papillomavirus Infections
Analysis and clinical implications of K-ras gene mutations and infection with human papillomavirus types 16 and 18 in primary adenocarcinoma of the uterine cervix.
Coexistence of K-ras mutations and HPV infection in colon cancer.
Detection of human papilloma virus (HPV) and K-ras mutations in human lung carcinomas.
H-ras oncogene mutation and human papillomavirus infection in oral carcinomas.
Human papillomavirus and colorectal cancer: evidences and pitfalls of published literature.
Human Papillomavirus DNA and Oncogene Alterations in Colorectal Tumors.
K-ras expression--marker of dysplasia and cancer.
K-ras Mutation, HPV Infection and Smoking or Alcohol Abuse Positively Correlate with Esophageal Squamous Carcinoma.
K-ras mutations and HPV infection in cervicitis and intraepithelial neoplasias of the cervix.
Significance of HPV Infection and Genic Mutation of APC and K-ras in Patients with Rectal Cancer.
[Express of human papillomavirus, P53 and H-ras gene in laryngeal cancer]
Paraganglioma
Integrative genetic characterization and phenotype correlations in pheochromocytoma and paraganglioma tumours.
Somatic mutations in H-RAS in sporadic pheochromocytoma and paraganglioma identified by exome sequencing.
Paralysis
Cdc42 mediates cancer cell chemotaxis in perineural invasion.
Combined Assessment of Serum Alpha-Synuclein and Rab35 is a Better Biomarker for Parkinson's Disease.
Increased Rab35 expression is a potential biomarker and implicated in the pathogenesis of Parkinson's disease.
Rab3A deletion selectively reduces spontaneous neurotransmitter release at the mouse neuromuscular synapse.
Paramyxoviridae Infections
Critical role of Rab11a-mediated recycling endosomes in the assembly of type I parainfluenza viruses.
Rab27a facilitates human parainfluenza virus type 2 growth by promoting cell surface transport of envelope proteins.
Paraproteinemias
Mutational activation of N- and K-ras oncogenes in plasma cell dyscrasias.
N- and K-ras oncogenes in plasma cell dyscrasias.
RAS mutations are uncommon in multiple myeloma and other monoclonal gammopathies.
Reduction of serum IGF-I levels in patients affected with Monoclonal Gammopathies of undetermined significance or Multiple Myeloma. Comparison with bFGF, VEGF and K-ras gene mutation.
Parasitic Diseases
Enzymatically active Rho and Rac small-GTPases are involved in the establishment of the vacuolar membrane after Toxoplasma gondii invasion of host cells.
Parathyroid Neoplasms
Genetic abnormalities in sporadic parathyroid adenomas.
Paratuberculosis
The Mycobacterium avium subsp. paratuberculosis MAP3464 gene encodes an oxidoreductase involved in invasion of bovine epithelial cells through the activation of host cell Cdc42.
Parkinson Disease
Alpha-synuclein binding to rab3a in multiple system atrophy.
Combined Assessment of Serum Alpha-Synuclein and Rab35 is a Better Biomarker for Parkinson's Disease.
Functional variant rs17525453 within RAB35 gene promoter is possibly associated with increased risk of Parkinson's disease in Taiwanese population.
Increased Rab35 expression is a potential biomarker and implicated in the pathogenesis of Parkinson's disease.
Overexpression of MicroRNA-133a Inhibits Apoptosis and Autophagy in a Cell Model of Parkinson's Disease by Downregulating Ras-Related C3 Botulinum Toxin Substrate 1 (RAC1).
Rab29 activation of the Parkinson's disease-associated LRRK2 kinase.
Rho GTPase regulation of ?-synuclein and VMAT2: Implications for pathogenesis of Parkinson's disease.
Structural Basis for Rab8a Recruitment of RILPL2 via LRRK2 Phosphorylation of Switch 2.
Synaptic proteins in CSF relate to Parkinson's disease stage markers.
Synaptic proteins predict cognitive decline in Alzheimer's disease and Lewy body dementia.
The small GTPase activity of the ROC domain from LRRK2, a Parkinson's disease related protein.
The Small GTPase RAC1/CED-10 Is Essential in Maintaining Dopaminergic Neuron Function and Survival Against ?-Synuclein-Induced Toxicity.
Therapeutic effects of the Rho GTPase modulator CNF1 in a model of Parkinson's disease.
Parkinsonian Disorders
Clinical and Neuropathological Features Associated With Loss of RAB39B.
Distribution of Parkinson's disease associated RAB39B in mouse brain tissue.
Increased Rab35 expression is a potential biomarker and implicated in the pathogenesis of Parkinson's disease.
Sex differences in autophagy-mediated diseases: toward precision medicine.
Pemphigus
Pemphigus IgG causes skin splitting in the presence of both desmoglein 1 and desmoglein 3.
Peptic Ulcer
Analysis of p53, K-ras gene mutation & Helicobacter pylori infection in patients with gastric cancer & peptic ulcer disease at a tertiary care hospital in north India.
Past medical conditions and K-ras mutations in pancreatic ductal adenocarcinoma: a hypothesis-generating study.
Peri-Implantitis
LncRNA-mediated ceRNA network was identified as a crucial determinant of differential effects in periodontitis and periimplantitis by high-throughput sequencing.
Periodontitis
LncRNA-mediated ceRNA network was identified as a crucial determinant of differential effects in periodontitis and periimplantitis by high-throughput sequencing.
Peripheral Nerve Injuries
C3 exoenzyme lacks effects on peripheral axon regeneration in vivo.
Cdc42 Promotes Schwann Cell Proliferation and Migration Through Wnt/?-Catenin and p38 MAPK Signaling Pathway After Sciatic Nerve Injury.
Control of Axonal Growth and Regeneration of Sensory Neurons by the p110delta PI 3-Kinase.
MiR-7 inhibited peripheral nerve injury repair by affecting neural stem cells migration and proliferation through cdc42.
Peripheral Nervous System Diseases
An altered lipid metabolism characterizes Charcot-Marie-Tooth type 2B peripheral neuropathy.
Exclusive expression of the Rab11 effector SH3TC2 in Schwann cells links integrin-?6 and myelin maintenance to Charcot-Marie-Tooth disease type 4C.
IFN-?/mTORC1 decreased Rab11 in Schwann cells of diabetic peripheral neuropathy, inhibiting cell proliferation via GLUT1 downregulation.
Myelin is dependent on the Charcot-Marie-Tooth Type 4H disease culprit protein FRABIN/FGD4 in Schwann cells.
Novel role of Cdc42 and RalA GTPases in TNF-? mediated secretion of CCL2.
Persistent Infection
Rab27b regulates extracellular vesicle production in cells infected with Kaposi's sarcoma-associated herpesvirus to promote cell survival and persistent infection.
Peutz-Jeghers Syndrome
Gastric-type endocervical glandular neoplasms associated with aberrant p16 expression and K-RAS gene mutation in Peutz-Jeghers syndrome.
[Genome analyses for precancerous lesions in the gastrointestinal tract]
Phenylketonurias
[Hypomelanoses transmitted from generation to generation].
Pheochromocytoma
Absent ras gene mutations in human adrenal cortical neoplasms and pheochromocytomas.
Cdc42 and Rac1 activity is reduced in human pheochromocytoma and correlates with FARP1 and ARHGEF1 expression.
H-RAS mutations are restricted to sporadic pheochromocytomas lacking specific clinical or pathological features: data from a multi-institutional series.
Inhibition of Cdc42 and Rac1 activities in pheochromocytoma, the adrenal medulla tumor.
Integrative genetic characterization and phenotype correlations in pheochromocytoma and paraganglioma tumours.
Low frequency of ras gene mutations in neuroblastomas, pheochromocytomas, and medullary thyroid cancers.
Microinjection of the ras oncogene protein into PC12 cells induces morphological differentiation.
Rab13 regulates neurite outgrowth in PC12 cells through its effector protein, JRAB/MICAL-L2.
ras mutations in endocrine tumors: mutation detection by polymerase chain reaction-single strand conformation polymorphism.
Rit contributes to nerve growth factor-induced neuronal differentiation via activation of B-Raf-extracellular signal-regulated kinase and p38 mitogen-activated protein kinase cascades.
Sodium nitroprusside induces H-Ras depalmitoylation and alters the cellular response to hypoxia in differentiated and undifferentiated PC12 cells.
Somatic mutations in H-RAS in sporadic pheochromocytoma and paraganglioma identified by exome sequencing.
The effect of exogenous human ras and myc oncogenes in morphological differentiation of the rat pheochromocytoma PC12 cells.
The human Rab genes encode a family of GTP-binding proteins related to yeast YPT1 and SEC4 products involved in secretion.
Phyllodes Tumor
Development of mouse models of malignant phyllodes tumors by transplantation of syngeneic mammary gland cells expressing mutant H-Ras.
Pick Disease of the Brain
Altered Distribution of RhoA in Alzheimer's Disease and AbetaPP Overexpressing Mice.
Altered distribution of RhoA in Alzheimer's disease and AbetaPP overexpressing mice.
Piebaldism
A founder RAB27A variant causes Griscelli syndrome type 2 with phenotypic heterogeneity in Qatari families.
Biochemical and functional characterization of Rab27a mutations occurring in Griscelli syndrome patients.
Chromosomal mapping, gene structure and characterization of the human and murine RAB27B gene.
Clinical presentation of Griscelli syndrome type 2 and spectrum of RAB27A mutations.
Functional characterization of two RAB27A missense mutations found in Griscelli syndrome type 2.
Griscelli syndrome type 2: A rare and fatal syndrome in a South Indian boy.
Novel 47.5-kb deletion in RAB27A results in severe Griscelli Syndrome Type 2.
Rab27a mediates the tight docking of insulin granules onto the plasma membrane during glucose stimulation.
Pigmentation Disorders
Role of Rab family GTPases and their effectors in melanosomal logistics.
Pituitary Neoplasms
Biomarkers of pituitary carcinomas.
Genetic basis of pituitary adenoma invasiveness: a review.
H-ras mutations in human pituitary carcinoma metastases.
Identification of mutant K-RAS in pituitary macroadenoma.
Immunocytochemical analysis of the synaptic proteins SNAP-25 and Rab3A in human pituitary adenomas. Overexpression of SNAP-25 in the mammmosomatotroph lineages.
MicroRNA-143 shows tumor suppressive effects through inhibition of oncogenic K-Ras in pituitary tumor.
Molecular pathogenesis of pituitary tumours.
Rab18 is reduced in pituitary tumors causing acromegaly and its overexpression reverts growth hormone hypersecretion.
[Pathophysiology and gene abnormalities of endocrine tumors]
Plasmacytoma
Extensive extramedullary disease in myeloma. An uncommon variant with features of poor prognosis and dedifferentiation.
Platelet Storage Pool Deficiency
The regulation of platelet-dense granules by Rab27a in the ashen mouse, a model of Hermansky-Pudlak and Griscelli syndromes, is granule-specific and dependent on genetic background.
Pleural Effusion
Detection of K-ras point mutations in the supernatants of peritoneal and pleural effusions for diagnosis complementary to cytologic examination.
Diagnostic value of the FHIT and p16 mRNA loss and the K-ras gene mutation in pleural fluids for malignant pleural effusion.
K-ras and rho A mutations in malignant pleural effusion.
[Expressions of 8-OH-dG, k-ras, and p53 genes in pleural effusion cells and their clinical significances]
Pleural Effusion, Malignant
Diagnostic value of the FHIT and p16 mRNA loss and the K-ras gene mutation in pleural fluids for malignant pleural effusion.
Differential mRNA expression of Toll-like receptors and their adaptors in pleural effusions.
K-ras and rho A mutations in malignant pleural effusion.
Pneumococcal Infections
Immunization with pneumococcal elongation factor Tu enhances serotype-independent protection against Streptococcus pneumoniae infection.
Pneumococcal DNA-binding proteins released through autolysis induce the production of proinflammatory cytokines via toll-like receptor 4.
Pneumonia
Cdc42 and RhoB activation are required for mannose receptor-mediated phagocytosis by human alveolar macrophages.
COPD-Type lung inflammation promotes K-ras mutant lung cancer through epithelial HIF-1? mediated tumor angiogenesis and proliferation.
Critical role of the small GTPase RhoA in the development of pulmonary edema induced by Pseudomonas aeruginosa in mice.
Immunoproteomic to analysis the pathogenicity factors in leukopenia caused by Klebsiella pneumonia bacteremia.
K-ras Mutations in Lung Tumors from NNK-treated Mice with Lipopolysaccharide-elicited Lung Inflammation.
KLF4 regulates adult lung tumor-initiating cells and represses K-Ras-mediated lung cancer.
Lysine trimethylation of EF-Tu mimics platelet-activating factor to initiate Pseudomonas aeruginosa pneumonia.
Slit2 Regulates Attractive Eosinophil and Repulsive Neutrophil Chemotaxis through Differential srGAP1 Expression during Lung Inflammation.
The small GTPase Rap1b negatively regulates neutrophil chemotaxis and transcellular diapedesis by inhibiting Akt activation.
Polycystic Kidney, Autosomal Dominant
Renal activation of extracellular signal-regulated kinase in rats with autosomal-dominant polycystic kidney disease.
Polycythemia Vera
Leukemogenic risk of hydroxyurea therapy as a single agent in polycythemia vera and essential thrombocythemia: N- and K-ras mutations and microsatellite instability in chromosomes 5 and 7 in 69 patients.
Polydactyly
Loss of function IFT27 variants associated with an unclassified lethal fetal ciliopathy with renal agenesis.
Polyomavirus Infections
Identification of Rab18 as an Essential Host Factor for BK Polyomavirus Infection Using a Whole-Genome RNA Interference Screen.
Porcine Reproductive and Respiratory Syndrome
Direct Regulation of the NADPH Oxidase RBOHD by the PRR-Associated Kinase BIK1 during Plant Immunity.
Expansion of pathogen recognition specificity in plants using pattern recognition receptors and artificially designed decoys.
The Arabidopsis Leucine-Rich Repeat Receptor-Like Kinases BAK1/SERK3 and BKK1/SERK4 Are Required for Innate Immunity to Hemibiotrophic and Biotrophic Pathogens.
The oomycete microbe-associated molecular pattern Pep-13 triggers SERK3/BAK1-independent plant immunity.
Precancerous Conditions
K-ras and Dpc4 mutations in chronic pancreatitis: case series.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Defective K-Ras oncoproteins overcome impaired effector activation to initiate leukemia in vivo.
H-ras and c-myc RNA expression in human T-cell ALL and in normal human lymphocytes.
MEK and PI3K-AKT inhibitors synergistically block activated IL7 receptor signaling in T-cell acute lymphoblastic leukemia.
Regulation of Small GTPase Rab20 by Ikaros in B-Cell Acute Lymphoblastic Leukemia.
Statins inhibit T-acute lymphoblastic leukemia cell adhesion and migration through Rap1b.
Synteny mapping of four genes from the short arm of human chromosome 19 to bovine chromosome 7.
[Detection of K-ras and p-53 oncogene mutations in a patient with acute lymphoblastic leukemia before and after bone marrow transplantation]
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Analysis of Rho GTPase expression in T-ALL identifies RhoU as a target for Notch involved in T-ALL cell migration.
Genetic mutational profiling analysis of T cell acute lymphoblastic leukemia reveal mutant FBXW7 as a prognostic indicator for inferior survival.
Statins inhibit T-acute lymphoblastic leukemia cell adhesion and migration through Rap1b.
Premature Birth
Genetic Associations with Gestational Duration and Spontaneous Preterm Birth.
Primary Immunodeficiency Diseases
A novel RAB27A mutation in a patient with Griscelli syndrome type 2.
Activation of compensatory pathways via Rac2 in the absence of the Cdc42 effector Wiskott-Aldrich syndrome protein in Dendritic cells.
EuroFlow Standardized Approach to Diagnostic Immunopheneotyping of Severe PID in Newborns and Young Children.
Oral features of Griscelli syndrome type II: A rare case report.
Primary Myelofibrosis
Infantile Myelofibrosis and Myeloproliferation with CDC42 Dysfunction.
Progressive decline of T and B cell numbers and function in a patient with CDC42 deficiency.
Systemic Inflammation and Myelofibrosis in a Patient with Takenouchi-Kosaki Syndrome due to CDC42 Tyr64Cys Mutation.
Prolactinoma
Ras mutations in human pituitary tumors.
ras mutations in human prolactinomas and pituitary carcinomas.
prostaglandin-endoperoxide synthase deficiency
Genetic ablation of cyclooxygenase-2 in keratinocytes produces a cell-autonomous defect in tumor formation.
Prostatic Hyperplasia
Abnormal expression of Rab27B in prostatic epithelial cells of benign prostatic hyperplasia alters intercellular communication.
In-silico identification and characterization of organic and inorganic chemical stress responding genes in yeast (Saccharomyces cerevisiae).
Increased oxidative stress with gene alteration in urinary bladder urothelium after the Chernobyl accident.
Prostatic Neoplasms
?3?1 Integrin Suppresses Prostate Cancer Metastasis via Regulation of the Hippo Pathway.
A novel nuclear role for the Vav3 nucleotide exchange factor in androgen receptor coactivation in prostate cancer.
A Rac1/Cdc42 GTPase-Specific Small Molecule Inhibitor Suppresses Growth of Primary Human Prostate Cancer Xenografts and Prolongs Survival in Mice.
Aberrant Rheb-mediated mTORC1 activation and Pten haploinsufficiency are cooperative oncogenic events.
Activating mutations of ras family genes in prostatic-cancer.
An oncogene-tumor suppressor cascade drives metastatic prostate cancer by coordinately activating Ras and nuclear factor-kappaB.
Application of pyrosequencing technique for improved detection of K-Ras mutation in formalin-fixed and paraffin-embedded prostate carcinoma tissues in Chinese patients.
CCL2 induces prostate cancer transendothelial cell migration via activation of the small GTPase Rac.
Deregulation of the Rho GTPase, Rac1, suppresses cyclin-dependent kinase inhibitor p21(CIP1) levels in androgen-independent human prostate cancer cells.
Differential expression of ETS family members in prostate cancer tissues and androgen-sensitive and insensitive prostate cancer cell lines.
Downregulation of Rab23 in Prostate Cancer Inhibits Tumor Growth In Vitro and In Vivo.
ERBB2 increases metastatic potentials specifically in androgen-insensitive prostate cancer cells.
Evaluation and characterization of anti-RalA autoantibody as a potential serum biomarker in human prostate cancer.
Extracellular ATP enhances in vitro invasion of prostate cancer cells by activating Rho GTPase and upregulating MMPs expression.
H-ras expression, genetic instability, and acquisition of metastatic ability by rat prostatic cancer cells following v-H-ras oncogene transfection.
HNF1b is involved in prostate cancer risk via modulating androgenic hormone effects and coordination with other genes.
In silico identification of key genes and signaling pathways targeted by a panel of signature microRNAs in prostate cancer.
Individual rac GTPases mediate aspects of prostate cancer cell and bone marrow endothelial cell interactions.
Induction of entosis in prostate cancer cells by nintedanib and its therapeutic implications.
Inhibition of Cdc42-intersectin interaction by small molecule ZCL367 impedes cancer cell cycle progression, proliferation, migration, and tumor growth.
Inhibition of the GTPase Rac1 Mediates the Antimigratory Effects of Metformin in Prostate Cancer Cells.
Inhibitor 9 Combined With Androgen Deprivation Therapy or Chemotherapy Delays the Malignant Behavior of Castration-Resistant Prostate Cancer Through K-Ras/PLC?/PKC? Signaling Pathway.
Insights into oncogenic mutations of plexin-B1 based on the solution structure of the Rho GTPase binding domain.
Integration of regulatory networks by NKX3-1 promotes androgen-dependent prostate cancer survival.
K-ras and Wnt signaling synergize to accelerate prostate tumorigenesis in the mouse.
Ligand-independent activation of androgen receptors by Rho GTPase signaling in prostate cancer.
MiR-203 down-regulates Rap1A and suppresses cell proliferation, adhesion and invasion in prostate cancer.
miR-338-3p targets RAB23 and suppresses tumorigenicity of prostate cancer cells.
miR-769-5p is associated with prostate cancer recurrence and modulates proliferation and apoptosis of cancer cells.
miR?367?3p downregulates Rab23 expression and inhibits Hedgehog signaling resulting in the inhibition of the proliferation, migration, and invasion of prostate cancer cells.
Modulation of E-cadherin expression by K-Ras; involvement of DNA methyltransferase-3b.
Mutations of ras genes are relatively frequent in Japanese prostate cancers: pointing to genetic differences between populations.
Novel Interaction between the Co-chaperone Cdc37 and Rho GTPase Exchange Factor Vav3 Promotes Androgen Receptor Activity and Prostate Cancer Growth.
Novel Regulation of Integrin Trafficking by Rab11-FIP5 in Aggressive Prostate Cancer.
Partial growth suppression of human prostate cancer cells by the Krev-1 suppressor gene.
Phenylboronic acid is a more potent inhibitor than boric acid of key signaling networks involved in cancer cell migration.
RAB27A, RAB27B and VPS36 are downregulated in advanced prostate cancer and show functional relevance in prostate cancer cells.
Rap2 regulates androgen sensitivity in human prostate cancer cells.
Ras mutation, irrespective of cell type and p53 status, determines a cell's destiny to undergo apoptosis by okadaic acid, an inhibitor of protein phosphatase 1 and 2A.
Reduction of pp32 expression in poorly differentiated pancreatic ductal adenocarcinomas and intraductal papillary mucinous neoplasms with moderate dysplasia.
RIAM controls invasion and growth of melanoma cells.
Role of p115RhoGEF in the regulation of extracellular Ca(2+)-induced choline kinase activation and prostate cancer cell proliferation.
Targeting protein geranylgeranylation slows tumor development in a murine model of prostate cancer metastasis.
The Epigenetic Factor KDM2B Regulates EMT and Small GTPases in Colon Tumor Cells.
The non-canonical mechanism of ER stress-mediated progression of prostate cancer.
Trop-2 promotes prostate cancer metastasis by modulating ?1 integrin functions.
Vav3 enhances androgen receptor splice variant activity and is critical for castration-resistant prostate cancer growth and survival.
Vav3, a Rho GTPase guanine nucleotide exchange factor, increases during progression to androgen independence in prostate cancer cells and potentiates androgen receptor transcriptional activity.
[Role of Rho GTPase in inhibiting metastatic ability of human prostate cancer cell line PC-3 by omega-3 polyunsaturated fatty acid]
[Small RNA interference-mediated ADP-ribosylation factor 6 silencing inhibits proliferation, migration and invasion of human prostate cancer PC-3 cells].
Protein Deficiency
Cdc42 GTPase-activating protein deficiency promotes genomic instability and premature aging-like phenotypes.
Early-onset colorectal cancer: A distinct entity with unique genetic features.
protein-synthesizing gtpase deficiency
Cdc42 GTPase-activating protein deficiency promotes genomic instability and premature aging-like phenotypes.
Proteinuria
Cdc42 deficiency induces podocyte apoptosis by inhibiting the Nwasp/stress fibers/YAP pathway.
Divergent functions of the Rho GTPases Rac1 and Cdc42 in podocyte injury.
Nuclear factor of activated T-cells mediates RhoA-induced fibronectin upregulation in glomerular podocytes.
Podocyte-specific loss of cdc42 leads to congenital nephropathy.
Proteinuria and glomerular damage in Rab3A knockout mice chronically fed a high-glucose diet.
Rab27a dependent exosome releasing participated in albumin handling as a coordinated approach to lysosome in kidney disease.
Rab38 modulates proteinuria in model of hypertension-associated renal disease.
Rho GTPase regulatory proteins in podocytes.
Role of guanine nucleotide exchange factor-H1 in complement-mediated RhoA activation in glomerular epithelial cells.
Small Rab GTPases in Intracellular Vesicle Trafficking: The Case of Rab3A/Raphillin-3A Complex in the Kidney.
Pseudarthrosis
Mechanical microenvironments and protein expression associated with formation of different skeletal tissues during bone healing.
Pseudorabies
The US3 Protein of Pseudorabies Virus Drives Viral Passage across the Basement Membrane in Porcine Respiratory Mucosa Explants.
Psoriasis
Epidermal activation of the small GTPase Rac1 in psoriasis pathogenesis.
Transcriptomic landscaping of core genes and pathways of mild and severe psoriasis vulgaris.
Pterygium
K-ras oncogene mutation in pterygium.
Pathogenetic mechanisms and treatment options for ophthalmic pterygium: Trends and perspectives (Review).
Pulmonary Arterial Hypertension
Fluoxetine inhibits monocrotaline-induced pulmonary arterial remodeling involved in inhibition of RhoA-Rho kinase and Akt signalling pathways in rats.
Pulmonary Blastoma
p53 and K-ras mutational genotyping in pulmonary carcinosarcoma, spindle cell carcinoma, and pulmonary blastoma: implications for histogenesis.
Pulmonary Disease, Chronic Obstructive
Cdc42 participates in the occurrence of chronic obstructive pulmonary disease by regulating migration of inflammatory cells.
Exosomal expression of RAB27A and its related lncRNA Lnc-RNA-RP11-510M2 in lung cancer.
Promotion of Lung Carcinogenesis by COPD-like Airway Inflammation in a K-ras Induced Mouse Model.
Targeting the mevalonate cascade as a new therapeutic approach in heart disease, cancer and pulmonary disease.
Tumor necrosis factor links chronic obstructive pulmonary disease and K-ras mutant lung cancer through induction of an immunosuppressive pro-tumor microenvironment.
[Effects of mTOR-Cdc42 signaling pathway on phagocytosis of alveolar macrophages in chronic obstructive pulmonary disease mice].
Pulmonary Edema
Cingulin role in agonist-induced vascular endothelial permeability.
Critical role of the small GTPase RhoA in the development of pulmonary edema induced by Pseudomonas aeruginosa in mice.
Cytoprotective-selective Activated Protein C Attenuates P. aeruginosa-induced Lung Injury in Mice.
Pulmonary Fibrosis
Fasudil, a rho-kinase inhibitor, attenuates bleomycin-induced pulmonary fibrosis in mice.
Mitochondrial Rac1 GTPase import and electron transfer from cytochrome c are required for pulmonary fibrosis.
Pulmonary Sclerosing Hemangioma
Microsatellite and EGFR, HER2 and K-RAS analyses in sclerosing hemangioma of the lung.
Purpura, Thrombocytopenic, Idiopathic
Study of oncogenic transformation in ex vivo expanded mesenchymal cells, from paediatric bone marrow.
Rectal Neoplasms
Alcohol and the risk of colon and rectal cancer with mutations in the K-ras gene.
Association between H-RAS T81C genetic polymorphism and gastrointestinal cancer risk: a population based case-control study in China.
Co-mutation of p53, K-ras genes and accumulation of p53 protein and its correlation to clinicopathological features in rectal cancer.
Comparative analysis of radiosensitizers for K-RAS mutant rectal cancers.
Dietary folate intake and k-ras mutations in sporadic colon and rectal cancer in The Netherlands Cohort Study.
Different genetic features associated with colon and rectal carcinogenesis.
Epidermal growth factor receptor gene copy number, K-ras mutation and pathological response to preoperative cetuximab, 5-FU and radiation therapy in locally advanced rectal cancer.
Fat and K-ras mutations in sporadic colorectal cancer in The Netherlands Cohort Study.
Genetic alterations of K-ras may reflect prognosis in stage III colon cancer patients below 60 years of age.
Meat consumption and K-ras mutations in sporadic colon and rectal cancer in The Netherlands Cohort Study.
Molecular genetic changes associated with colorectal carcinogenesis are not prognostic for tumor regression following preoperative chemoradiation of rectal carcinoma.
p53 and K-ras gene mutations in carcinoma of the rectum among Finnish women.
Reappraisal of K-ras and p53 gene mutations in the recurrence of Dukes' B2 rectal cancer after curative resection.
Significance of HPV Infection and Genic Mutation of APC and K-ras in Patients with Rectal Cancer.
The role of circulating tumor cells and K-ras mutations in patients with locally advanced rectal cancer: a prospective study.
[A case of advanced rectal cancer treated with leucovorin, fluorouracil, and oxaliplatin plus panitumumab preoperative chemotherapy].
[A case of remnant liver metastases after resection of liver metastases from rectal cancer following treatment with 5-FU, L-OHP and CPT-11, with markedly effective treatment by cetuximab plus S-1].
[K-ras mutations in rectal cancer undergone preoperative radiotherapy]
[Mixed adenoneuroendocrine carcinoma with multiple liver metastases successfully treated by cetuximab/CPT-11 chemotherapy followed by curative resection - a case report].
Renal Insufficiency
Cdc42 deficiency causes ciliary abnormalities and cystic kidneys.
Morphological and proliferative abnormalities in renal mesangial cells lacking RhoGDI.
Podocyte-specific loss of cdc42 leads to congenital nephropathy.
Renal Insufficiency, Chronic
CDC42 promotes vascular calcification in chronic kidney disease.
Rab27a dependent exosome releasing participated in albumin handling as a coordinated approach to lysosome in kidney disease.
Rac1-Mediated Effects of HMG-CoA Reductase Inhibitors (Statins) in Cardiovascular Disease.
Reperfusion Injury
Aberrant regulation of planar cell polarity in polycystic kidney disease.
Exosomes/microvesicles microRNA-423-3p derived from cardiac fibroblasts mediates the cardioprotective effects of ischemic postconditioning.
Inhibition of the Rac1 GTPase protects against nonlethal ischemia/reperfusion-induced necrosis and apoptosis in vivo.
Involvement of Rho-kinase in cold ischemia-reperfusion injury after liver transplantation in rats.
PKN1 Directs Polarized RAB21 Vesicle Trafficking via RPH3A and Is Important for Neutrophil Adhesion and Ischemia-Reperfusion Injury.
Spinal cord ischemia-reperfusion causes damage of neurocyte by inhibiting RAP2C.
Retinal Degeneration
CDC42 is required for tissue lamination and cell survival in the mouse retina.
Molecular cloning and characterization of human RAB23, a member of the group of Rab GTPases.
Retinal degeneration modulates intracellular localization of CDC42 in photoreceptors.
The bacterial toxin CNF1 as a tool to induce retinal degeneration reminiscent of retinitis pigmentosa.
Retinal Neoplasms
Ras activation in retinal progenitor cells induces tumor formation in the eye.
Retinitis Pigmentosa
Arl3 and RP2 regulate the trafficking of ciliary tip kinesins.
Interaction of retinitis pigmentosa GTPase regulator (RPGR) with RAB8A GTPase: implications for cilia dysfunction and photoreceptor degeneration.
Isobaric Tags for Relative and Absolute Quantitation-Based Proteomic Analysis of Patent and Constricted Ductus Arteriosus Tissues Confirms the Systemic Regulation of Ductus Arteriosus Closure.
Mistrafficking of prenylated proteins causes retinitis pigmentosa 2.
Photoreceptor cGMP phosphodiesterase delta subunit (PDEdelta) functions as a prenyl-binding protein.
The bacterial toxin CNF1 as a tool to induce retinal degeneration reminiscent of retinitis pigmentosa.
The X-linked retinitis pigmentosa protein RP2 facilitates G protein traffic.
Retinoblastoma
Abnormal expression of the retinoblastoma gene in ovarian neoplasms and correlation to p53 and K-ras mutations.
Activated k-ras, but not h-ras or N-ras, regulates brain neural stem cell proliferation in a raf/rb-dependent manner.
Alterations of tumor suppressor genes and the H-ras oncogene in oral squamous cell carcinoma.
CML: mechanisms of disease initiation and progression.
Co-deletions of the retinoblastoma gene and Wilms' tumor gene and rearrangement of the Krev-1 gene in a human insulinoma.
Expressions of Rac1, Tiam1 and Cdc42 in retinoblastoma.
Gene analysis of K-, H-ras, p53, and retinoblastoma susceptibility genes in human lung cancer cell lines by the polymerase chain reaction/single-strand conformation polymorphism method.
Human hepatocyte carcinogenesis (Review).
Immunohistochemical analysis of MIB-1 proliferative activity in human endometrial cancer. Correlation with clinicopathological parameters, patient outcome, retinoblastoma immunoreactivity and K-ras codon 12 point mutations.
Immunohistochemical and genetic analysis of non-small cell and small cell gallbladder carcinoma and their precursor lesions.
K-ras exon 2 point mutations in human endometrial cancer.
Loss of Rb overrides the requirement for ERK activity for cell proliferation.
Molecular markers in lung cancer: prognostic role and relationship to smoking.
Molecular pattern of ductal pancreatic cancer.
No occurrence of DNA-polymerase Beta-gene mutation in human lung-carcinoma cell-lines with k-ras as, p53, or rb gene alterations.
Orthotopic xenografts of human pancreatic carcinomas acquire genetic aberrations during dissemination in nude mice.
PI3K/Akt pathway mutations in Retinoblastoma.
Rac and Cdc42 are potent stimulators of E2F-dependent transcription capable of promoting retinoblastoma susceptibility gene product hyperphosphorylation.
Retinoblastoma protein (pRB) was significantly phosphorylated through a Ras-to-MAPK pathway in mutant K-ras stably transfected human adrenocortical cells.
The retinoblastoma gene Rb and its family member p130 suppress lung adenocarcinoma induced by oncogenic K-Ras.
Retroviridae Infections
Cytoplasmic retention of p-Erk1/2 and nuclear accumulation of actin proteins during cellular senescence in human diploid fibroblasts.
Rhabdoid Tumor
Cloning and characterization of a novel Rab-family gene, Rab36, within the region at 22q11.2 that is homozygously deleted in malignant rhabdoid tumors.
Isolation of genes from the rhabdoid tumor deletion region in chromosome band 22q11.2.
Rhabdomyosarcoma
Cooperation of oncogenic K-ras and p53 deficiency in pleomorphic rhabdomyosarcoma development in adult mice.
H-ras and K-ras mutations in soft tissue sarcoma: comparative studies of sarcomas from Korean and American patients.
Influence of the H-ras oncogene on radiation responses of a rat rhabdomyosarcoma cell line.
Mutational status of K-ras and TP53 genes in primary sarcomas of the heart.
Participation of small GTPases Rac1 and Cdc42Hs in myoblast transformation.
Small GTPase Arl6 controls RH30 rhabdomyosarcoma cell growth through ciliogenesis and Hedgehog signaling.
Rhabdomyosarcoma, Embryonal
Detection of point mutations in N-ras and K-ras genes of human embryonal rhabdomyosarcomas using oligonucleotide probes and the polymerase chain reaction.
T-cell acute lymphoblastic leukemia following therapy of rhabdomyosarcoma.
RNA Virus Infections
The small GTPase RAB1B promotes antiviral innate immunity by interacting with TNF receptor-associated factor 3 (TRAF3).
Salmonella Infections
Salmonella-directed recruitment of new membrane to invasion foci via the host exocyst complex.
The Salmonella Effector SseK3 Targets Small Rab GTPases.
Sarcoidosis
A genome-wide association study reveals evidence of association with sarcoidosis at 6p12.1.
Sarcoma
?-Catenin Does Not Confer Tumorigenicity When Introduced into Partially Transformed Human Mesenchymal Stem Cells.
A human vascular endothelial cell model to study angiogenesis and tumorigenesis.
A molecular approach to leukemogenesis: mouse lymphomas contain an activated c-ras oncogene.
A ras-related gene with transformation suppressor activity.
Activation of ras oncogenes and expression of tumor-specific transplantation antigens in methylcholanthrene-induced murine fibrosarcomas.
Activation of Ras overcomes B-cell tolerance to promote differentiation of autoreactive B cells and production of autoantibodies.
Alkalinization of the lysosomes is correlated with ras transformation of murine and human fibroblasts.
Altered ganglioside expression in ras-oncogene-transformed cells.
Analysis of p53 and K-ras genes and their proteins in a sarcoma botryoides of the uterine cervix.
Analysis of the c-myc, K-ras and p53 genes in methylcholanthrene-induced mouse sarcomas.
Association of minisatellite instability with c-myc amplification and K-ras mutation in methylcholanthrene-induced mouse sarcomas.
Atypical Fibroxanthoma.
Carcinosarcoma colliding osteosarcoma of the pancreas: a rare case report of multiple clonal originated pancreatic tumors.
Changes in cellular gene expression in rat thyroid epithelial cells transformed by the Kirsten murine sarcoma virus.
Chromosomal abnormalities and gene amplification in renal cancers induced in rats by nickel subsulfide.
Clinical relevance of KRAS in human cancers.
Codon 12 and codon 13 mutations at the K-ras gene induce different soft tissue sarcoma types in nude mice.
Contributions of intrinsic mutation rate and selfish selection to levels of de novo HRAS mutations in the paternal germline.
Detection of a rare point mutation at codon 59 and relatively high incidence of H-ras mutation in Indian oral cancer.
Detection of K-ras mutations in resected primary leiomyosarcoma.
Development and analysis of a transformation-defective mutant of Harvey murine sarcoma tk virus and its gene product.
Diagnostic value of K-ras mutation analysis for pancreaticobiliary cytology specimens with indeterminate diagnosis.
Evidence that sprouty 2 is necessary for sarcoma formation by H-Ras oncogene-transformed human fibroblasts.
Expression of normal and transforming H-ras genes in Escherichia coli and purification of their encoded p21 proteins.
Expression of the ras-related rap genes in human tumors.
Genomic and Metabolomic Analysis of Step-Wise Malignant Transformation in Human Skin Fibroblasts.
GGT to GTT transversions in codon 12 of the K-ras oncogene in rat renal sarcomas induced with nickel subsulfide or nickel subsulfide/iron are consistent with oxidative damage to DNA.
Glucocorticoid-enhanced neoplastic transformation of human keratinocytes by human papillomavirus type 16 and an activated ras oncogene.
H-ras and K-ras gene mutations in primary human soft tissue sarcoma: concomitant mutations of the ras genes.
H-ras and K-ras mutations in soft tissue sarcoma: comparative studies of sarcomas from Korean and American patients.
H-ras oncogene activation in invasive UVR-induced corneal sarcomas of the opossum Monodelphis domestica.
H-ras-1 point mutations in soft tissue sarcomas.
Harvey murine sarcoma virus p21 ras protein: biological and biochemical significance of the cysteine nearest the carboxy terminus.
Identification of a novel salivary biomarker miR-143-3p for periodontal diagnosis: A proof of concept study.
Identification of a novel tumor transforming gene GAEC1 at 7q22 which encodes a nuclear protein and is frequently amplified and overexpressed in esophageal squamous cell carcinoma.
Immunophenotype and K-RAS mutation in mucinous ovarian adenocarcinoma with mural nodule of high-grade sarcoma: case report.
Inactivation of O(6)-methylguanine-DNA methyltransferase in soft tissue sarcomas: association with K-ras mutations.
K-Ras gene status and expression of Ras/mitogen-activated protein kinase (MAPK) signaling molecules in ameloblastomas.
K-Ras Mutations in Non-Small-Cell Lung Cancer: Prognostic and Predictive Value.
Malignant transformation of an infinite life span human fibroblast cell strain by transfection with v-Ki-ras.
Malignant transformation of human fibroblasts by oncogene transfection or carcinogen treatment.
Molecular cloning, genomic analysis, and biological properties of rat leukemia virus and the onc sequences of Rasheed rat sarcoma virus.
Molecular genetics and cellular events of K-Ras-driven tumorigenesis.
Mouse cells contain two distinct ras gene mRNA species that can be translated into a p21 onc protein.
Mutational status of K-ras and TP53 genes in primary sarcomas of the heart.
Neoplastic transformation of human epidermal keratinocytes by AD12-SV40 and Kirsten sarcoma viruses.
NRAS isoforms differentially affect downstream pathways, cell growth, and cell transformation.
Oncogenicity of human N-ras oncogene and proto-oncogene introduced into retroviral vectors.
Ovarian mucinous tumor with malignant mural nodules: dedifferentiation or collision?
Placental Ras Regulates Inflammation Associated with Maternal Obesity.
Production of chimeric protein coded by the fused viral H-ras and human N-ras genes in Escherichia coli.
Rab11-mediated focal adhesion turnover in sarcoma cell migration.
Spatiotemporal metabolic dynamics of the photosensitizer talaporfin sodium in carcinoma and sarcoma.
Stress-induced proteins in immune response to cancer.
Targeting sphingosine kinase 1 (SK1) enhances oncogene-induced senescence through ceramide synthase 2 (CerS2)-mediated generation of very-long-chain ceramides.
The Emerging Role of the RAB25 Small GTPase in Cancer.
The Long Noncoding RNA
Tumorigenic transformation of mammalian cells induced by a normal human gene homologous to the oncogene of Harvey murine sarcoma virus.
Upregulated miRNA-622 inhibited cell proliferation, motility, and invasion via repressing Kirsten rat sarcoma in glioblastoma.
Sarcoma, Avian
Epidermal growth factor and oncogenes induce transcription of the same cellular mRNA in rat fibroblasts.
Sarcoma, Kaposi
Gene amplification and multiple mutations of the K-ras oncogene in Kaposi's sarcoma.
Sarcoma, Synovial
Molecular abnormalities of p53, MDM2, and H-ras in synovial sarcoma.
Schistosomiasis
Contrasting molecular pathology of colorectal carcinoma in Egyptian and Western patients.
[Regulatory effects of RhoGTPase on transition of liver sinusoidal capillarization: experiment with mice of schistosomal hepatic fibrosis]
Seizures
Cooperative regulation of neurotransmitter release by Rab3a and synapsin II.
Inhibition of the small GTPase Cdc42 in regulation of epileptic-seizure in rats.
The first case of myoclonic epilepsy in a child with a de novo 22q11.2 microduplication.
Seminoma
K-RAS and N-RAS mutations in testicular germ cell tumors.
Primary mediastinal and testicular seminomas: a comparison of K-ras-2 gene sequence and p53 immunoperoxidase analysis of 26 cases.
Sepsis
Comparative analysis of Histophilus somni IbpA with other FIC enzymes reveals differences in substrate and nucleotide specificities.
Potential role of lncRNA HULC/miR?128?3p/RAC1 axis in the inflammatory response during LPS?induced sepsis in HMEC?1 cells.
Severe Combined Immunodeficiency
EuroFlow Standardized Approach to Diagnostic Immunopheneotyping of Severe PID in Newborns and Young Children.
Overexpression of mutant ras in human melanoma increases invasiveness, proliferation and anchorage-independent growth in vitro and induces tumour formation and cachexia in vivo.
Sexually Transmitted Diseases
The Prevalence of HIV by Ethnic Group Is Correlated with HSV-2 and Syphilis Prevalence in Kenya, South Africa, the United Kingdom, and the United States.
Shock, Septic
Leukocyte transcellular diapedesis: Rap1b is in control.
Sigmoid Neoplasms
[A case of sigmoid colon cancer with liver and ovarian metastases effectively treated by panitumumab after acquiring resistance to prior chemotherapy regimens].
[Two cases of metastatic colorectal cancer in wild-type K-RAS effectively treated by panitumumab].
Silicosis
A distinct mutational spectrum of p53 and K-ras genes in lung cancer of workers with silicosis.
Skin Neoplasms
Considerations for skin carcinogenesis experiments using inducible transgenic mouse models.
IKKalpha is required to maintain skin homeostasis and prevent skin cancer.
Impact of point mutation P29S in RAC1 on tumorigenesis.
Mapping of UV photoproducts within ras proto-oncogenes in UV-irradiated cells: correlation with mutations in human skin cancer.
Multiple stages in radiation carcinogenesis of rat skin.
Skin Cancers and the Contribution of Rho GTPase Signaling Networks to Their Progression.
Small Cell Lung Carcinoma
Genetic analysis of the catalytic domain of the GAP gene in human lung cancer cell lines.
High TUBB3 expression, an independent prognostic marker in patients with early non small cell lung cancer (NSCLC) treated by preoperative chemotherapy, is regulated by K-Ras signaling pathway.
microRNA-195 Promotes Small Cell Lung Cancer Cell Apoptosis via Inhibiting Rap2C Protein-Dependent MAPK Signal Transduction.
No occurrence of DNA-polymerase Beta-gene mutation in human lung-carcinoma cell-lines with k-ras as, p53, or rb gene alterations.
The small GTPase RhoA has greater expression in small cell lung carcinoma than in non-small cell lung carcinoma and contributes to their unique morphologies.
small monomeric gtpase deficiency
A critical role of Rap1b in B-cell trafficking and marginal zone B-cell development.
Cdc42 and Rab8a are critical for intestinal stem cell division, survival, and differentiation in mice.
Cdc42 critically regulates the balance between myelopoiesis and erythropoiesis.
Cdc42 deficiency causes ciliary abnormalities and cystic kidneys.
Cdc42 deficiency causes Sonic hedgehog-independent holoprosencephaly.
Cdc42 deficiency induces podocyte apoptosis by inhibiting the Nwasp/stress fibers/YAP pathway.
Cdc42 Deficiency Leads To Epidermal Barrier Dysfunction by Regulating Intercellular Junctions and Keratinization of Epidermal Cells during Mouse Skin Development.
Cdc42 is required for male germline niche development in mice.
Cdc42 is required for PIP(2)-induced actin polymerization and early development but not for cell viability.
Cdc42 regulates extracellular matrix remodeling in three dimensions.
Cdc42-dependent actin dynamics controls maturation and secretory activity of dendritic cells.
Cell Division Cycle 42 plays a Cell type-Specific role in Lung Tumorigenesis.
Congenital biliary atresia is correlated with disrupted cell junctions and polarity caused by Cdc42 insufficiency in the liver.
Distinct role of rab27a in granule movement at the plasma membrane and in the cytosol of NK cells.
Dynamin Binding Protein (Tuba) deficiency inhibits ciliogenesis and nephrogenesis in vitro and in vivo.
Endothelial Cdc42 deficiency impairs endothelial regeneration and vascular repair after inflammatory vascular injury.
ENU mutagenesis identifies mice modeling Warburg Micro Syndrome with sensory axon degeneration caused by a deletion in Rab18.
Genetic deletion of Rab27B in pancreatic acinar cells affects granules size and has inhibitory effects on amylase secretion.
Parcas is the predominant Rab11-GEF for rhodopsin transport in Drosophila photoreceptors.
Pharmacological inhibition of EGFR signaling enhances G-CSF-induced hematopoietic stem cell mobilization.
Podocyte-specific loss of cdc42 leads to congenital nephropathy.
Progressive decline of T and B cell numbers and function in a patient with CDC42 deficiency.
RAB GTPASE HOMOLOG 8D is required for the maintenance of both the root stem cell niche and the meristem.
Rab11-mediated focal adhesion turnover in sarcoma cell migration.
Rab27a and Rab27b regulate neutrophil azurophilic granule exocytosis and NADPH oxidase activity by independent mechanisms.
Rab27A Is Present in Mouse Pancreatic Acinar Cells and Is Required for Digestive Enzyme Secretion.
Rab27A regulates transport of cell surface receptors modulating multinucleation and lysosome-related organelles in osteoclasts.
Rab3a is critical for trapping alpha-MSH granules in the high Ca²?-affinity pool by preventing constitutive exocytosis.
Rab3a-mediated vesicle recruitment regulates short-term plasticity at the mouse diaphragm synapse.
Rab8a Deficiency in Skeletal Muscle Causes Hyperlipidemia and Hepatosteatosis by Impairing Muscle Lipid Uptake and Storage.
Rac deletion in osteoclasts causes severe osteopetrosis.
Rad GTPase deficiency leads to cardiac hypertrophy.
Rap1a deficiency modifies cytokine responses and MAPK-signaling in vitro and impairs the in vivo inflammatory response.
Rap1b is required for normal platelet function and hemostasis in mice.
Rational targeting Cdc42 restrains Th2 cell differentiation and prevents allergic airway inflammation.
Reciprocal Regulation of Glycolysis-Driven Th17 Pathogenicity and Regulatory T Cell Stability by Cdc42.
Rho GTPase Cdc42 coordinates hematopoietic stem cell quiescence and niche interaction in the bone marrow.
Rubella vaccine-induced granulomas are a novel phenotype with incomplete penetrance of genetic defects in cytotoxicity.
The K-Ras 4A isoform promotes apoptosis but does not affect either lifespan or spontaneous tumor incidence in aging mice.
The RAB2B-GARIL5 Complex Promotes Cytosolic DNA-Induced Innate Immune Responses.
The Small GTPase Cdc42 Negatively Regulates the Formation of Neutrophil Extracellular Traps by Engaging Mitochondria.
The small GTPase Rap1b negatively regulates neutrophil chemotaxis and transcellular diapedesis by inhibiting Akt activation.
Vascular endothelial Cdc42 deficiency delays skin wound-healing processes by increasing IL-1? and TNF-? expression.
Warburg Micro syndrome is caused by RAB18 deficiency or dysregulation.
Spasms, Infantile
Bi-allelic Variants in RALGAPA1 Cause Profound Neurodevelopmental Disability, Muscular Hypotonia, Infantile Spasms, and Feeding Abnormalities.
Spinal Cord Injuries
Aldynoglia cells and modulation of RhoGTPase activity as useful tools for spinal cord injury repair.
Functional Genome-wide Screen Identifies Pathways Restricting Central Nervous System Axonal Regeneration.
Lesional RhoA+ cell numbers are suppressed by anti-inflammatory, cyclooxygenase-inhibiting treatment following subacute spinal cord injury.
Mevalonate Cascade and small Rho GTPase in Spinal Cord Injury.
microRNA-331-3p attenuates neuropathic pain following spinal cord injury via targeting RAP1A.
Prolonged lesional expression of RhoA and RhoB following spinal cord injury.
RhoA, RhoB, RhoC, Rac1, Cdc42, and Tc10 mRNA levels in spinal cord, sensory ganglia, and corticospinal tract neurons and long-lasting specific changes following spinal cord injury.
Squamous Cell Carcinoma of Head and Neck
Activated Vav2 modulates cellular invasion through Rac1 and Cdc42 in oral squamous cell carcinoma.
Alterations of tumor suppressor genes and the H-ras oncogene in oral squamous cell carcinoma.
Amplification of wild-type K-ras promotes growth of head and neck squamous cell carcinoma.
Comprehensive Mutation Analysis of PIK3CA, p14ARF, p16INK4a and p21Waf1/Cip1 Genes is Suggestive of a Non- Neoplastic Nature of Phenytoin Induced Gingival Overgrowth.
Does Harvey-Ras gene expression lead to oral squamous cell carcinoma? A clinicopathological aspect.
ERK2-dependent reactivation of Akt mediates the limited response of tumor cells with constitutive K-RAS activity to PI3K inhibition.
Expression and mutation analysis of epidermal growth factor receptor in head and neck squamous cell carcinoma.
H-ras oncogene mutation and human papillomavirus infection in oral carcinomas.
Histone deacetylase inhibitors suppress aggressiveness of head and neck squamous cell carcinoma via histone acetylation-independent blockade of the EGFR-Arf1 axis.
Identification of insulin-like growth factor binding protein-3 as a farnesyl transferase inhibitor SCH66336-induced negative regulator of angiogenesis in head and neck squamous cell carcinoma.
Identification of RAB2A and PRDX1 as the potential biomarkers for oral squamous cell carcinoma using mass spectrometry-based comparative proteomic approach.
Imipramine blue halts head and neck cancer invasion through promoting F-box and leucine-rich repeat protein 14-mediated Twist1 degradation.
Impact of K-Ras Over-expression in Laryngeal Squamous Cell Carcinoma.
K-RAS mutations in laryngeal squamous cell carcinoma.
Localization of H-ras mRNA in oral squamous cell carcinomas.
Loss of transforming growth factor-beta type II receptor promotes metastatic head-and-neck squamous cell carcinoma.
MERTK as a novel therapeutic target in head and neck cancer.
miR-181a shows tumor suppressive effect against oral squamous cell carcinoma cells by downregulating K-ras.
MiR-181d functions as a potential tumor suppressor in oral squamous cell carcinoma by targeting K-ras.
MiR-206 functions as a tumor suppressor and directly targets K-Ras in human oral squamous cell carcinoma [Retraction].
MiR-206 functions as a tumor suppressor and directly targets K-Ras in human oral squamous cell carcinoma.
Oncogenes in head and neck cancer.
Overexpression of Rac-1 small GTPase binding protein in oral squamous cell carcinoma.
Persistent activation of Rac1 in squamous carcinomas of the head and neck: evidence for an EGFR/Vav2 signaling axis involved in cell invasion.
Prevalence of K-ras Codon 12 Mutations in Indian Patients with Head and Neck Cancer.
Prevalence of K-RAS Codons 12 and 13 Mutations in Locally Advanced Head and Neck Squamous Cell Carcinoma and Impact on Clinical Outcomes.
Prognostic significance of molecular markers in oral squamous cell carcinoma: A multivariate analysis.
Rab18 Regulates Proliferation, Invasion and Cisplatin Sensitivity Through STAT3 Signaling in Head and Neck Squamous Cell Carcinoma.
Rac1 as a potential therapeutic target for chemo-radioresistant head and neck squamous cell carcinomas (HNSCC).
Ral GTPase Activation by Downregulation of RalGAP Enhances Oral Squamous Cell Carcinoma Progression.
Recruitment of Tiam1 to Semaphorin 4D Activates Rac and Enhances Proliferation, Invasion, and Metastasis in Oral Squamous Cell Carcinoma.
Repression of bone morphogenetic protein 4 by let-7i attenuates mesenchymal migration of head and neck cancer cells.
S100A7 has an oncogenic role in oral squamous cell carcinoma by activating p38/MAPK and RAB2A signaling pathway.
Schedule-dependent interaction between temsirolimus and cetuximab in head and neck cancer: a preclinical study.
Silencing Ras-Related C3 Botulinum Toxin Substrate 1 Inhibits Growth and Migration of Hypopharyngeal Squamous Cell Carcinoma via the P38 Mitogen-Activated Protein Kinase Signaling Pathway.
Studies on the Contribution of Cox-2 Expression in the Progression of Oral Squamous Cell Carcinoma and H-Ras Activation.
The amplification of c-erb-B2 in cancer-free surgical margins is a predictor of poor outcome in oral squamous cell carcinoma.
Wnt5b promotes the cell motility essential for metastasis of oral squamous cell carcinoma through active Cdc42 and RhoA.
[The expressions of K-ras in human laryngeal squamous cell carcinoma cell lines (Hep-2) and its significance]
Starvation
Defects in the secretory pathway and high Ca2+ induce multiple P-bodies.
Distinctive Responses to Nitrogen Starvation in the Dominant Active Mutants of the Fission Yeast Rheb GTPase.
Fission Yeast Rho5p GTPase Is a Functional Paralogue of Rho1p That Plays a Role in Survival of Spores and Stationary-Phase Cells.
Golgi-Resident GTPase Rab30 Promotes the Biogenesis of Pathogen-Containing Autophagosomes.
Isoprenoid modification of rab proteins terminating in CC or CXC motifs.
Phosphatidylinositol 3-kinase, Cdc42, and Rac1 act downstream of Ras in integrin-dependent neurite outgrowth in N1E-115 neuroblastoma cells.
Rab18 is not necessary for lipid droplet biogenesis or turnover in human mammary carcinoma cells.
Regulation of microtubule dynamics in 3T3 fibroblasts by Rho family GTPases.
Small GTPase Tc10 and its homologue RhoT induce N-WASP-mediated long process formation and neurite outgrowth.
Starvation-induced MTMR13 and RAB21 activity regulates VAMP8 to promote autophagosome-lysosome fusion.
Stress resistance conferred by neuronal expression of dominant-negative Rac in adult Drosophila melanogaster.
Stress-mediated inhibition of the classical nuclear protein import pathway and nuclear accumulation of the small GTPase Gsp1p.
The elongation factor Tu from Escherichia coli, aminoacyl-tRNA, and guanosine tetraphosphate form a ternary complex which is bound by programmed ribosomes.
The RHEB-mTOR axis regulates expression of Tf2 transposons in fission yeast.
Transcriptional Regulation Buffers Gene Dosage Effects on a Highly Expressed Operon in Salmonella.
Translation inhibition reveals interaction of 2'-deoxy and 2'-O-methyl molecular beacons with mRNA targets in living cells.
Stomach Diseases
Quantitative analysis of representative proteome components and clustering of Helicobacter pylori clinical strains.
Stomach Neoplasms
A New Rho(d) Map to Diffuse Gastric Cancer.
Analysis of p53, K-ras gene mutation & Helicobacter pylori infection in patients with gastric cancer & peptic ulcer disease at a tertiary care hospital in north India.
APC gene is modulated by hsa-miR-135b-5p in both diffuse and intestinal gastric cancer subtypes.
Association between H-RAS T81C genetic polymorphism and gastrointestinal cancer risk: a population based case-control study in China.
Augmentation of immune response by an analog of the antigenic peptide in a human T-cell clone recognizing mutated Ras-derived peptides.
BRAF mutations characterize colon but not gastric cancer with mismatch repair deficiency.
BRAF/K-ras mutation, microsatellite instability, and promoter hypermethylation of hMLH1/MGMT in human gastric carcinomas.
c-myc Gene amplification in primary stomach cancer.
Clinicopathologic significance of the K-ras gene codon 12 point mutation in stomach cancer. An analysis of 140 cases.
Comparison of K-ras mutations in lung, colorectal and gastric cancer.
Correlation of COX-2 and K-ras expression to clinical outcome in gastric cancer.
E-cadherin and K-ras: implications of a newly developed model of gastric cancer.
Effects of CDC42 on the proliferation and invasion of gastric cancer cells.
Effects of microRNA-29 family members on proliferation and invasion of gastric cancer cell lines.
EGF Stimulates Rab35 Activation and Gastric Cancer Cell Migration by Regulating DENND1A-Grb2 Complex Formation.
Expression of RAP1B is associated with poor prognosis and promotes an aggressive phenotype in gastric cancer.
Expression of seven main Rho family members in gastric carcinoma.
Expression of ST3GAL4 leads to SLe(x) expression and induces c-Met activation and an invasive phenotype in gastric carcinoma cells.
FARP1 boosts CDC42 activity from integrin ?v?5 signaling and correlates with poor prognosis of advanced gastric cancer.
Frequent overexpression, but not activation by point mutation, of ras genes in primary human gastric cancers.
Gene alterations in intestinal metaplasia and gastric cancer.
Genetic and epigenetic changes in stomach cancer.
Genetic changes in multi-step development of colorectal cancer.
Genetic mutations of p53 and k-ras in gastric carcinoma patients from Hunan, China.
Human ZNF312b promotes the progression of gastric cancer by transcriptional activation of the K-ras gene.
In vitro and in vivo antitumor activity of cetuximab in human gastric cancer cell lines in relation to epidermal growth factor receptor (EGFR) expression and mutational phenotype.
Inhibition by D-limonene of gastric carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine in Wistar rats.
Integrative genomics identifies RAB23 as an invasion mediator gene in diffuse-type gastric cancer.
K-RAS mutation in gastric cancer and its link with microsatellite instability status.
K-ras mutation in helicobacter pylori-associated chronic gastritis in patients with and without gastric cancer.
K-ras mutation influences macroscopic features of gastric carcinoma.
K-ras mutations and cell kinetics in Helicobacter pylori associated gastric intestinal metaplasia: a comparison before and after eradication in patients with chronic gastritis and gastric cancer.
Knockdown of Rap1b Enhances Apoptosis and Autophagy in Gastric Cancer Cells via the PI3K/Akt/mTOR Pathway.
Knockdown of RAP2A gene expression suppresses cisplatin resistance in gastric cancer cells.
Loss of heterozygosity and K-ras gene mutations in gastric cancer.
Methionine represses the autophagy of gastric cancer stem cells via promoting the methylation and phosphorylation of RAB37.
MICAL2 Facilitates Gastric Cancer Cell Migration via MRTF-A-Mediated CDC42 Activation.
MicroRNA-31 inhibits RhoA-mediated tumor invasion and chemotherapy resistance in MKN-45 gastric adenocarcinoma cells.
MicroRNA-4268 inhibits cell proliferation via AKT/JNK signalling pathways by targeting Rab6B in human gastric cancer.
Microsatellite instability and K-ras mutations in gastric adenomas, with reference to associated gastric cancers.
miR-124-3p acts as a potential marker and suppresses tumor growth in gastric cancer.
miR-137 Is Frequently Down-Regulated in Gastric Cancer and Is a Negative Regulator of Cdc42.
miR-148b-3p inhibits gastric cancer metastasis by inhibiting the Dock6/Rac1/Cdc42 axis.
miR-182-5p improves the viability, mitosis, migration, and invasion ability of human gastric cancer cells by down-regulating RAB27A.
MiR-455-5p acts as a novel tumor suppressor in gastric cancer by down-regulating RAB18.
Molecular biology of gastric cancer.
Mutational analysis of BRAF and K-ras in gastric cancers: absence of BRAF mutations in gastric cancers.
NKX6.3 Is a Transcription Factor for Wnt/?-catenin and Rho-GTPase Signaling-Related Genes to Suppress Gastric Cancer Progression.
Nuclear translocation of small G protein RhoA via active transportation in gastric cancer cells.
Nucleotide variants within the IQGAP1 gene in diffuse-type gastric cancers.
Organ-specific profiles of genetic changes in cancers caused by activation-induced cytidine deaminase expression.
Phosphorylation of Ephrin-B1 Regulates Dissemination of Gastric Scirrhous Carcinoma.
Phosphorylation of ephrin-B1 regulates dissemination of gastric scirrhous carcinoma.
RAB13 as a novel prognosis marker promotes proliferation and chemotherapeutic resistance in gastric cancer.
Rab18 overexpression promotes proliferation and chemoresistance through regulation of mitochondrial function in human gastric cancer.
Rab3IP interacts with SSX2 and enhances the invasiveness of gastric cancer cells.
RCC2 Interacts with Small GTPase RalA and Regulates Cell Proliferation and Motility in Gastric Cancer.
Reversal of the malignant phenotype of gastric cancer cells by inhibition of RhoA expression and activity.
Rho GTPase RhoJ is Associated with Gastric Cancer Progression and Metastasis.
Roles of E-cadherin and Noncoding RNAs in the Epithelial-mesenchymal Transition and Progression in Gastric Cancer.
S-adenosylmethionine inhibits the growth of cancer cells by reversing the hypomethylation status of c-myc and H-ras in human gastric cancer and colon cancer.
Studies on the relationship between the point mutation of ras oncogenes and the prognosis of patients with gastric cancer.
Telomerase activity and its clinicopathological significance in gastric cancer.
TGF-beta signaling pathway inactivation and cell cycle deregulation in the development of gastric cancer: role of the beta-spectrin, ELF.
The microRNA-367 Inhibits the Invasion and Metastasis of Gastric Cancer by Directly Repressing Rab23.
The novel GINS4 axis promotes gastric cancer growth and progression by activating Rac1 and CDC42.
The role of ras gene mutation in gastric cancer and precancerous lesions.
Traditional Chinese medicine Jianpi Bushen therapy suppresses the onset of pre-metastatic niche in a murine model of spontaneous lung metastasis.
Transcriptome Analysis of the Inhibitory Effect of Astaxanthin on Helicobacter pylori-Induced Gastric Carcinoma Cell Motility.
Transduction effect of antisense K-ras on malignant phenotypes in gastric cancer cells.
UBE2C Is a Potential Biomarker of Intestinal-Type Gastric Cancer With Chromosomal Instability.
Upregulated expression of ROCK1 promotes cell proliferation by functioning as a target of miR-335-5p in non-small cell lung cancer.
Upregulation of miR-802 suppresses gastric cancer oncogenicity via targeting RAB23 expression.
YAP Regulates Actin Dynamics through ARHGAP29 and Promotes Metastasis.
[Characteristics of plasma DNA and its application for detection of K-ras gene mutation]
[Detection of G-->T mutation at codon 12 of H-ras oncogenes in gastric cancers with polymerase chain reaction and oligodeoxynucleotide(PCR-ODN)]
[Detection of ras gene mutation in various stages of gastric cancer by PCR/RFLP SSCP and DNA sequencing]
[Expression and mutation of p53 and H-ras genes in the carcinogenesis and development of gastric adenocarcinoma induced by MNNG in rats]
[Multistep stomach carcinogenesis]
[Research advances of K-ras mutation in the prognosis and targeted therapy of gastric cancer].
[Standardization of evaluation for target molecule in cancer therapy].
[Study on association between an H-RAS gene polymorphism and gastric cancer development]
[The roles of H. pylori infection and K-ras gene mutation in gastric carcinogenesis]
Stomatitis
Rab13 regulates membrane trafficking between TGN and recycling endosomes in polarized epithelial cells.
Strabismus
The Formin DAAM Functions as Molecular Effector of the Planar Cell Polarity Pathway during Axonal Development in Drosophila.
Striatonigral Degeneration
Alpha-synuclein binding to rab3a in multiple system atrophy.
Stroke
Identification of Co-expressed Genes Between Atrial Fibrillation and Stroke.
Novel Role for the AnxA1-Fpr2/ALX Signaling Axis as a Key Regulator of Platelet Function to Promote Resolution of Inflammation.
Rab7b Overexpression-Ameliorated Ischemic Brain Damage Following tMCAO Involves Suppression of TLR4 and NF-?B p65.
Rac1-Mediated Effects of HMG-CoA Reductase Inhibitors (Statins) in Cardiovascular Disease.
Ras-Related C3 Botulinum Toxin Substrate 1 Promotes Axonal Regeneration after Stroke in Mice.
Role of Rac1 GTPase in NADPH oxidase activation and cognitive impairment following cerebral ischemia in the rat.
Stroke, Lacunar
Aldynoglia cells and modulation of RhoGTPase activity as useful tools for spinal cord injury repair.
Superinfection
Baculovirus induces host cell aggregation via a Rho/Rok-dependent mechanism.
Supranuclear Palsy, Progressive
Combined Assessment of Serum Alpha-Synuclein and Rab35 is a Better Biomarker for Parkinson's Disease.
Increased Rab35 expression is a potential biomarker and implicated in the pathogenesis of Parkinson's disease.
Syndactyly
Carpenter syndrome: extended RAB23 mutation spectrum and analysis of nonsense-mediated mRNA decay.
Rab23 and developmental disorders.
Synucleinopathies
The GTPase Rab27b regulates the release, autophagic clearance, and toxicity of ?-synuclein.
The small GTPase Rab11 co-localizes with ?-synuclein in intracellular inclusions and modulates its aggregation, secretion and toxicity.
Syphilis
The Prevalence of HIV by Ethnic Group Is Correlated with HSV-2 and Syphilis Prevalence in Kenya, South Africa, the United Kingdom, and the United States.
Tangier Disease
Contribution of Cdc42 to cholesterol efflux in fibroblasts from Tangier disease and Werner syndrome.
Decreased expression of a member of the Rho GTPase family, Cdc42Hs, in cells from Tangier disease - the small G protein may play a role in cholesterol efflux.
Tauopathies
Patterns of neuronal Rhes as a novel hallmark of tauopathies.
Teratoma
K-ras proto-oncogene exhibits tumor suppressor activity as its absence promotes tumorigenesis in murine teratomas.
Testicular Neoplasms
K-ras oncogene codon 12 point mutations in testicular cancer.
Overexpression of RhoA, Rac1, and Cdc42 GTPases is associated with progression in testicular cancer.
Thrombasthenia
Rap1b association with the platelet cytoskeleton occurs in the absence of glycoproteins IIb/IIIa.
Thrombocythemia, Essential
Leukemogenic risk of hydroxyurea therapy as a single agent in polycythemia vera and essential thrombocythemia: N- and K-ras mutations and microsatellite instability in chromosomes 5 and 7 in 69 patients.
Thrombocytopenia
De novo missense variants in the RAP1B gene identified in two patients with syndromic thrombocytopenia.
Further evidence of a mutation in CDC42 as a cause of a recognizable syndromic form of thrombocytopenia.
Macrothrombocytopenia and developmental delay with a de novo CDC42 mutation: Yet another locus for thrombocytopenia and developmental delay.
Multiple alterations of platelet functions dominated by increased secretion in mice lacking Cdc42 in platelets.
Pathogenetic basis of Takenouchi-Kosaki syndrome: Electron microscopy study using platelets in patients and functional studies in a Caenorhabditis elegans model.
Polymorphism T81C in H-RAS Oncogene Is Associated With Disease Progression in Imatinib (TKI) Treated Chronic Myeloid Leukemia Patients.
Role of Rho-GTPases in megakaryopoiesis.
Thrombosis
A Functional Relevance of the Anaphylatoxin Receptor C3aR for Platelet Function and Arterial Thrombus Formation Marks an Intersection Point Between Innate Immunity and Thrombosis.
Amyloid ?-peptide-dependent activation of human platelets: essential role for Ca2+ and ADP in aggregation and thrombus formation.
Combined deficiency of RAB32 and RAB38 in the mouse mimics Hermansky-Pudlak syndrome and critically impairs thrombosis.
Increased leukocyte ROCK activity in patients after acute ischemic stroke.
MUNC13-4 IS CRITICAL FOR THROMBOSIS THROUGH REGULATING RELEASE OF ADP FROM PLATELETS.
Non-redundant roles of phosphoinositide 3-kinase isoforms alpha and beta in glycoprotein VI-induced platelet signaling and thrombus formation.
Pharmacologic targeting of Cdc42 GTPase by a small molecule Cdc42 activity-specific inhibitor prevents platelet activation and thrombosis.
Platelet Rho GTPase regulation in physiology and disease.
Porphyromonas gingivalis lipopolysaccharide activates platelet Cdc42 and promotes platelet spreading and thrombosis.
RASA3 is a critical inhibitor of RAP1-dependent platelet activation.
Regulation of the mTOR-Rac1 axis in platelet function.
Rho GTPase regulation of reactive oxygen species generation and signalling in platelet function and disease.
Rho GTPases in platelet function.
RhoGAPs and Rho GTPases in platelets.
TC21/RRas2 regulates glycoprotein VI-FcR?-mediated platelet activation and thrombus stability.
The GRAF family member Oligophrenin1 is a RhoGAP with a BAR domain and regulates Rho GTPases in platelets.
The Small GTPase Rap1b: A Bidirectional Regulator of Platelet Adhesion Receptors.
Thymoma
Analysis of transforming genes in indirectly induced radiogenic thymomas in mice.
Cetyltrimethylammonium Bromide Suppresses the Migration and Invasion of Hepatic Mahlavu Cells by Modulating Fibroblast Growth Factor Signaling.
Diagnosis of thymic epithelial tumor subtypes by a quantitative proteomic approach.
Thyroid Cancer, Papillary
A molecular expression signature distinguishing follicular lesions in thyroid carcinoma using preamplification RT-PCR in archival samples.
BRAF and K-RAS mutation in a Greek papillary and medullary thyroid carcinoma cohort.
Expression of p21 ras protein as a prognostic factor in papillary thyroid cancer.
Prevalence of RAS Point Mutations in Papillary Thyroid Carcinoma; A Novel Mutation at Codon 31 of K-RAS.
RAC1b overexpression stimulates proliferation and NF-kB-mediated anti-apoptotic signaling in thyroid cancer cells.
The Suppression of miR-199a-3p by Promoter Methylation Contributes to Papillary Thyroid Carcinoma Aggressiveness by Targeting RAP2a and DNMT3a.
Thyroid Carcinoma, Anaplastic
Inhibition of malignant thyroid carcinoma cell proliferation by Ras and galectin-3 inhibitors.
Thyroid Neoplasms
Absence of H- and K-ras oncogene mutations in sporadic medullary thyroid carcinoma.
Allelic loss of susceptibility loci and the occurrence of BRAF and RAS mutations in patients with familial non-medullary thyroid cancer.
Association between H-RAS T81C genetic polymorphism and gastrointestinal cancer risk: a population based case-control study in China.
Berberine could inhibit thyroid carcinoma cells by inducing mitochondrial apoptosis, G0/G1 cell cycle arrest and suppressing migration via PI3K-AKT and MAPK signaling pathways.
Blocking oncogenic Ras signaling for cancer therapy.
BRAF and K-RAS mutation in a Greek papillary and medullary thyroid carcinoma cohort.
BRAFV600E mutation: a potential predictor of more than a Sistrunk's procedure in patients with thyroglossal duct cyst carcinoma and a normal thyroid gland.
CircHIPK3 Promotes Thyroid Cancer Tumorigenesis and Invasion through the Mirna-338-3p/RAB23 Axis.
Deletion of Rap1b, but not Rap1a or Epac1, Reduces Protein Kinase A-Mediated Thyroid Cancer.
Downregulation of survivin and aurora a by histone deacetylase and RAS inhibitors: A new drug combination for cancer therapy.
Epigallocatechin-3-gallate inhibits the growth and increases the apoptosis of human thyroid carcinoma cells through suppression of EGFR/RAS/RAF/MEK/ERK signaling pathway.
Exogenous Hydrogen Sulfide Regulates the Growth of Human Thyroid Carcinoma Cells.
Expression of bcl-2, c-erbB-2, p53, and p21 (waf1-cip1) protein in thyroid carcinomas.
Functional Significance of the Novel H-RAS Gene Mutation M72I in a Patient with Medullary Thyroid Cancer.
Galectin-3 promotes chronic activation of K-Ras and differentiation block in malignant thyroid carcinomas.
Ginsenoside Rg3 Inhibition of Thyroid Cancer Metastasis Is Associated with Alternation of Actin Skeleton.
H-RAS 81 polymorphism is significantly associated with aneuploidy in follicular tumors of the thyroid.
H-ras protooncogene mutations in human thyroid neoplasms.
Highly Sensitive and Specific Molecular Test for Mutations in the Diagnosis of Thyroid Nodules: A Prospective Study of BRAF-Prevalent Population.
Infrequent activation of K-ras, H-ras, and other oncogenes in hepatocellular neoplasms initiated by methyl(acetoxymethyl)nitrosamine, a methylating agent, and promoted by phenobarbital in F344 rats.
Inhibition of malignant thyroid carcinoma cell proliferation by Ras and galectin-3 inhibitors.
Interaction between p53 and TGF beta 1 in control of epithelial cell proliferation.
Low frequency of TERT promoter mutations in a series of well-differentiated follicular-patterned thyroid neoplasms.
miR-206 inhibits thyroid cancer proliferation and invasion by targeting RAP1B.
miR-597-3p inhibits invasion and migration of thyroid carcinoma SW579 cell by targeting RAB23.
Rap2A Is Upregulated in Invasive Cells Dissected from Follicular Thyroid Cancer.
Rapid detection of K-, N-, H-RAS, and BRAF hotspot mutations in thyroid cancer using the multiplex primer extension.
ras mutations are associated with aggressive tumor phenotypes and poor prognosis in thyroid cancer.
Ras oncogene mutations in benign and malignant thyroid neoplasms.
Regulation of uptake of 18F-FDG by a follicular human thyroid cancer cell line with mutation-activated K-ras.
RET/papillary thyroid carcinoma oncogenic signaling through the Rap1 small GTPase.
Screening of specific changes in mRNAs in thyroid tumors by sequence specific differential display: decreased expression of c-fos mRNA in papillary carcinoma.
The role of Slit2 as a tumor suppressor in thyroid cancer.
Upregulation of the PI3K/Akt pathway in the tumorigenesis of canine thyroid carcinoma.
[Genetic alterations in human malignant tumor]
Thyroid Nodule
American College of Radiology thyroid imaging report and data system combined with K-RAS mutation improves the management of cytologically indeterminate thyroid nodules.
Combination of ultrasound and molecular testing in malignancy risk estimate of Bethesda category IV thyroid nodules: results from a single-institution prospective study.
PCR amplification and analysis of ras oncogenes from thyroid cytologic smears.
RAS Mutations in AUS/FLUS Cytology: Does it Have an Additional Role in BRAFV600E Mutation-Negative Nodules?
Tics
Rab15 alternative splicing is altered in spheres of neuroblastoma cells.
Toxoplasmosis
Small GTPase Immunity-Associated Proteins Mediate Resistance to Toxoplasma gondii Infection in Lewis Rat.
Trauma, Nervous System
Rabs and axonal regeneration.
Triple Negative Breast Neoplasms
A novel role for flotillin-1 in H-Ras-regulated breast cancer aggressiveness.
Loss of RAB1B promotes triple-negative breast cancer metastasis by activating TGF-?/SMAD signaling.
MicroRNA-145 functions as a tumor suppressor by targeting matrix metalloproteinase 11 and Rab GTPase family 27a in triple-negative breast cancer.
MicroRNA-192-5p inhibits migration of triple negative breast cancer cells and directly regulates Rho GTPase activating protein 19.
Non-canonical Notch Signaling Regulates Actin Remodeling in Cell Migration by Activating PI3K/AKT/Cdc42 Pathway.
RNAi screens for Rho GTPase regulators of cell shape and YAP/TAZ localisation in triple negative breast cancer.
Selective stabilization of multiple promoter G-quadruplex DNA by using 2-phenyl-1H-imidazole-based tanshinone IIA derivatives and their potential suppressing function in the metastatic breast cancer.
The Rho GTPase Rnd1 suppresses mammary tumorigenesis and EMT by restraining Ras-MAPK signalling.
The small GTPase ADP-Ribosylation Factor 1 mediates the sensitivity of triple negative breast cancer cells to EGFR tyrosine kinase inhibitors.
Trophoblastic Neoplasms
Decreased expression of Ras GTPase activating protein in human trophoblastic tumors.
Tuberculosis
Antibodies against mycobacterial antigens in the synovial fluid of patients with temporomandibular disorders.
Cloning and sequence determination of the gene coding for the elongation factor Tu of Mycobacterium leprae.
Deviant expression of Rab5 on phagosomes containing the intracellular pathogens Mycobacterium tuberculosis and Legionella pneumophila is associated with altered phagosomal fate.
Formulation and Intracellular Trafficking of Lipid-Drug Conjugate Nanoparticles Containing a Hydrophilic Antitubercular Drug for Improved Intracellular Delivery to Human Macrophages.
Interaction of Mycobacterium tuberculosis Elongation Factor Tu with GTP is regulated by phosphorylation.
Mapping and identification of the major cell wall-associated components of Mycobacterium leprae.
Rab6 regulates recycling and retrograde trafficking of MR1 molecules.
Ras-associated small GTPase 33A, a novel T cell factor, is down-regulated in patients with tuberculosis.
Tuberous Sclerosis
Amino Acid Regulation of TOR Complex 1.
dRAGging amino acid-mTORC1 signaling by SH3BP4.
Mechanism of Akt1 inhibition of breast cancer cell invasion reveals a protumorigenic role for TSC2.
Nutrient-responsive mTOR signalling grows on Sterile ground.
Phospholipase D1 is an effector of Rheb in the mTOR pathway.
Raptor, a binding partner of target of rapamycin.
Recent advances in the regulation of the TOR pathway by insulin and nutrients.
Rheb binds and regulates the mTOR kinase.
Rheb1 deletion in myeloid cells aggravates OVA-induced allergic inflammation in mice.
Selective inhibition of growth of tuberous sclerosis complex 2 null cells by atorvastatin is associated with impaired Rheb and Rho GTPase function and reduced mTOR/S6 kinase activity.
Sequence-specific 1H, 13C, and 15N backbone assignment of the activated 21 kDa GTPase rRheb.
Sequence-specific 1H, 13C, and 15N backbone assignment of the GTPase rRheb in its GDP-bound form.
TSC1-2 tumour suppressor and regulation of mTOR signalling: linking cell growth and proliferation?
Tsc2-Rheb signaling regulates EphA-mediated axon guidance.
Tuberous sclerosis complex 2 (TSC2) regulates cell migration and polarity through activation of CDC42 and RAC1.
tubulinyl-tyr carboxypeptidase deficiency
MAP1B regulates axonal development by modulating Rho-GTPase Rac1 activity.
Ureteral Obstruction
Deletion of H-Ras decreases renal fibrosis and myofibroblast activation following ureteral obstruction in mice.
Signaling mechanism of renal fibrosis in unilateral ureteral obstructive kidney disease in ROCK1 knockout mice.
Urinary Bladder Neoplasms
?-Lipoic acid suppresses migration and invasion via downregulation of cell surface ?1-integrin expression in bladder cancer cells.
A method to quantitatively detect H-ras point mutation based on electrochemiluminescence.
A PCR-RFLP method for the detection of activated H-ras oncogene with a point mutation at codon 12 and 61.
A single nucleotide polymorphism in the human H-ras proto-oncogene determines the risk of urinary bladder cancer.
Activated H-ras gene mutations in transitional cell carcinoma of urinary bladder in a Kashmiri population.
Activation of H-ras oncogene in rat bladder tumors induced by N-butyl-N-(4-hydroxybutyl)nitrosamine.
Activation of RAS family genes in urothelial carcinoma.
Adenovirus-mediated gene therapy for bladder cancer in an orthotopic model using a dominant negative H-ras mutant.
Analysis of p53, p16MTS, p21WAF1 and H-ras in archived bladder tumours from workers exposed to aromatic amines.
Androgen Receptor Signaling Reduces the Efficacy of Bacillus Calmette-Guérin Therapy for Bladder Cancer via Modulating Rab27b-Induced Exocytosis.
Carcinogenicity of dimethylarsinic acid in male F344 rats and genetic alterations in induced urinary bladder tumors.
Cell culture studies on the mechanism of action of chemical carcinogens and tumor promoters.
Cellular disposal of miR23b by RAB27-dependent exosome release is linked to acquisition of metastatic properties.
Clonal heterogeneity, experimental metastatic ability, and p21 expression in H-ras-transformed NIH 3T3 cells.
Correction to: Genetic aberrations of the K-ras proto-oncogene in bladder cancer in relation to pesticide exposure.
Correlation between the expression of the P21 ras oncogene product and the biological behavior of bladder tumors.
Detection of altered H-ras proteins in human tumors using western blot analysis.
Detection of H-ras gene point mutations in transitional cell carcinoma of human urinary bladder using polymerase chain reaction.
DNA methylation adduct formation and H-ras gene mutations in progression of N-butyl-N-(4-hydroxybutyl)nitrosamine-induced bladder tumors caused by a single exposure to N-methyl-N-nitrosourea.
Frequency of H-ras mutations in human bladder cancer detected by direct sequencing.
Genetic aberrations of the K-ras proto-oncogene in bladder cancer in Kashmiri population.
Genetic aberrations of the K-ras proto-oncogene in bladder cancer in relation to pesticide exposure.
Genomic instability and loh at 2 polymorphic sites in the h-ras1 gene.
H-ras activation and ras p21 expression in bladder tumors induced in F344/NCr rats by N-butyl-N-(4-hydroxybutyl)nitrosamine.
H-ras immunohistochemical expression and molecular analysis of urinary bladder lesions in grazing adult cattle exposed to bracken fern.
H-ras mutation detection in bladder cancer by COLD-PCR analysis and direct sequencing.
H-RAS mutation is a key molecular feature of pediatric urothelial bladder cancer. A detailed report of three cases.
H-ras oncogene mutations in the urine of patients with bladder-tumors - description of a noninvasive method for the detection of neoplasia.
H-RAS, K-RAS, and N-RAS gene activation in human bladder cancers.
Identification of H-ras mutations in urine sediments complements cytology in the detection of bladder tumors.
Inhibition of miR-1247 on cell proliferation and invasion in bladder cancer through its downstream target of RAB36.
Introduction of wild-type p53 gene downregulates the expression of H-ras gene and suppresses the growth of bladder cancer cells.
K-RAS mutation in transitional cell carcinoma of urinary bladder.
Lack of p53 and ras mutations in Helicobacter hepaticus-induced liver tumors in A/JCr mice.
LINC00319-Mediated miR-3127 Repression Enhances Bladder Cancer Progression Through Upregulation of RAP2A.
Mechanisms of multistage chemical carcinogenesis and their relevance to respiratory tract cancer.
microRNA-195 inhibits cell proliferation in bladder cancer via inhibition of cell division control protein 42 homolog/signal transducer and activator of transcription-3 signaling.
MiR-381-3p/RAB2A axis activates cell proliferation and inhibits cell apoptosis in bladder cancer.
Molecular epidemiology of pancreatic cancer.
Molecular mechanisms of tumor promotion and multistage carcinogenesis.
Molecular pathways of urothelial development and bladder tumorigenesis.
Mutation of H-ras is infrequent in bladder cancer: confirmation by single-strand conformation polymorphism analysis, designed restriction fragment length polymorphisms, and direct sequencing.
Novel RasGRF1-derived Tat-fused peptides inhibiting Ras-dependent proliferation and migration in mouse and human cancer cells.
Oligonucleotide treatment of ras-induced tumors in nude mice.
Oncogenic activation of Pak1-dependent pathway of macropinocytosis determines BCG entry into bladder cancer cells.
Oncogenic H-Ras, FK228, and exogenous H2O2 cooperatively activated the ERK pathway in selective induction of human urinary bladder cancer J82 cell death.
Overexpression of RIN1 associates with tumor grade and progression in patients of bladder urothelial carcinoma.
p14ARF promoter hypermethylation in plasma DNA as an indicator of disease recurrence in bladder cancer patients.
Phosphodiesterase 5 inhibitors enhance chemotherapy killing in gastrointestinal/genitourinary cancer cells.
Polymorphic variants of H-RAS protooncogene and their possible role in bladder cancer etiology.
Polymorphisms in DNA repair and metabolic genes in bladder cancer.
Proapoptotic ability of oncogenic H-Ras to facilitate apoptosis induced by histone deacetylase inhibitors in human cancer cells.
Rab11 Functions as an Oncoprotein via Nuclear Factor kappa B (NF-?B) Signaling Pathway in Human Bladder Carcinoma.
Rab23 is overexpressed in human bladder cancer and promotes cancer cell proliferation and invasion.
Rab27A overexpression promotes bladder cancer proliferation and chemoresistance through regulation of NF-?B signaling.
RAB38 promotes bladder cancer growth by promoting cell proliferation and motility.
Rac Family Small GTPase 3 Correlates with Progression and Poor Prognosis in Bladder Cancer.
Radiation sensitization of human cancer cells in vivo by inhibiting the activity of PI3K using LY294002.
Ral-Arf6 crosstalk regulates Ral dependent exocyst trafficking and anchorage independent growth signalling.
Reversibility of proliferative lesions and induction of non-papillary tumors in rat urinary bladder treated with phenylethyl isothiocyanate.
RNA-interference-mediated Cdc42 silencing down-regulates phosphorylation of STAT3 and suppresses growth in human bladder-cancer cells.
Role of reactive oxygen species in proapoptotic ability of oncogenic H-Ras to increase human bladder cancer cell susceptibility to histone deacetylase inhibitor for caspase induction.
Screening of H-ras gene point mutations in 50 cases of bladder carcinoma.
Screening of human bladder tumors and urine sediments for the presence of H-ras mutations.
Significance of the Grb2 and son of sevenless (Sos) proteins in human bladder cancer cell lines.
Some ras-transformed cells have increased radiosensitivity and decreased repair of sublethal radiation damage.
Suppressive effects of dominant negative ras mutant N116Y on transformed phenotypes of human bladder cancer cells.
The farnesyltransferase inhibitor, FTI-2153, inhibits bipolar spindle formation during mitosis independently of transformation and Ras and p53 mutation status.
The long noncoding RNA KTN1-AS1 promotes bladder cancer tumorigenesis via KTN1 cis-activation and the consequent initiation of Rho GTPase-mediated signaling.
The Ral GTPase pathway in metastatic bladder cancer: key mediator and therapeutic target.
The role of Ras superfamily proteins in bladder cancer progression.
Therapeutic efficacy of an adenovirus-mediated anti-H-ras ribozyme in experimental bladder cancer.
Transcriptional activation of H-ras, K-ras and N-ras proto-oncogenes in human bladder tumors.
UBIAD1 suppresses the proliferation of bladder carcinoma cells by regulating H-Ras intracellular trafficking via interaction with the C-terminal domain of H-Ras.
Use of an anti-ras ribozyme to alter the malignant phenotype of a human bladder cancer cell line.
Vascular endothelial growth factor, p53, and the H-ras oncogene in Egyptian patients with bladder cancer.
Urinary Retention
Urinary Retention, Incontinence, and Dysregulation of Muscarinic Receptors in Male Mice Lacking Mras.
Urologic Neoplasms
RhoA is associated with invasion and lymph node metastasis in upper urinary tract cancer.
Uterine Cervical Neoplasms
"Low-risk" and "high-risk" HPV-infection and K-ras gene point mutations in human cervical cancer: a study of 31 cases.
Cdc42 expression in cervical cancer and its effects on cervical tumor invasion and migration.
Dock10, a Cdc42 and Rac1 GEF, induces loss of elongation, filopodia, and ruffles in cervical cancer epithelial HeLa cells.
Expression and mutation of H-ras in uterine cervical cancer.
Genetic alterations in the K-Ras gene influence the prognosis in patients with cervical cancer treated by radiotherapy.
H-ras codon 12 mutation in cervical dysplasia.
Hypoxia stimulates invasion and migration of human cervical cancer cell lines HeLa/SiHa through the Rab11 trafficking of integrin ?v?3/FAK/PI3K pathway-mediated Rac1 activation.
METTL3 regulates the malignancy of cervical cancer via post-transcriptional regulation of RAB2B.
Micro ribonucleic acid-93 promotes oncogenesis of cervical cancer by targeting RAB11 family interacting protein 1.
MicroRNA-425 induces apoptosis and suppresses migration and invasion of human cervical cancer cells by targeting RAB2B.
MicroRNA-720 promotes in vitro cell migration by targeting Rab35 expression in cervical cancer cells.
MiR-29a inhibits cell proliferation and migration by targeting the CDC42/PAK1 signaling pathway in cervical cancer.
Nuclear expression of Rac1 in cervical premalignant lesions and cervical cancer cells.
Overexpression of ARHGAP30 suppresses growth of cervical cancer cells by downregulating ribosome biogenesis.
Overexpression of the BRIP1 ameliorates chemosensitivity to cisplatin by inhibiting Rac1 GTPase activity in cervical carcinoma HeLa cells.
Rac1 GTPase-deficient HeLa cells present reduced DNA repair, proliferation, and survival under UV or gamma irradiation.
Radiation-induced increase in cell migration and metastatic potential of cervical cancer cells operates via the K-Ras pathway.
Role of miR-337-3p and its target Rap1A in modulating proliferation, invasion, migration and apoptosis of cervical cancer cells.
The effect of HMGB1 on the clinicopathological and prognostic features of cervical cancer.
The relevance of oncogenes as prognostic markers in cervical cancer.
The roles of Cdc42 and Rac1 in the formation of plasma membrane protrusions in cancer epithelial HeLa cells.
Transcriptional activation of H- and N-ras oncogenes in human cervical cancer.
[Analysis of prevalence of point mutations in codon 12 of oncogene K-ras from non-cancerous samples of cervical cytology positive for type 16 or 18 PVH]
[Effect of Rab11 gene expression on the invasion and migration of cervical cancer cell line SiHa in hypoxia].
[miR-143 inhibits cell proliferation through targeted regulating the expression of K-ras gene in HeLa cells].
Uterine Cervicitis
K-ras mutations and HPV infection in cervicitis and intraepithelial neoplasias of the cervix.
[Clinical significance of p21H-ras expression and H-ras codon 12 mutation in squamous intraepithelial lesion (SIL) and carcinoma of uterine cervix]
Uterine Neoplasms
K-ras mutations in lung tumors and tumors from other organs are consistent with a common mechanism of ethylene oxide tumorigenesis in the B6C3F1 mouse.
Vaccinia
A complex of N-WASP and WIP integrates signalling cascades that lead to actin polymerization.
A role for the small GTPase Rac1 in vaccinia actin-based motility.
Association of Rap1a and Rap1b proteins with late endocytic/phagocytic compartments and Rap2a with the Golgi complex.
Cdc42 and Rac stimulate exocytosis of secretory granules by activating the IP(3)/calcium pathway in RBL-2H3 mast cells.
Cdc42 facilitates invasion but not the actin-based motility of Shigella.
Identification of a human CD8+ T lymphocyte neo-epitope created by a ras codon 12 mutation which is restricted by the HLA-A2 allele.
Intracellular Transport of Vaccinia Virus in HeLa Cells Requires WASH-VPEF/FAM21-Retromer Complexes and Recycling Molecules Rab11 and Rab22.
lncRNA UCA1-Mediated Cdc42 Signaling Promotes Oncolytic Vaccinia Virus Cell-to-Cell Spread in Ovarian Cancer.
Mutant RBL mast cells defective in Fc epsilon RI signaling and lipid raft biosynthesis are reconstituted by activated Rho-family GTPases.
The formin FHOD1 and the small GTPase Rac1 promote vaccinia virus actin-based motility.
The RAB2B-GARIL5 Complex Promotes Cytosolic DNA-Induced Innate Immune Responses.
Vascular Calcification
CDC42 promotes vascular calcification in chronic kidney disease.
Vascular Diseases
Endothelial Cdc42 deficiency impairs endothelial regeneration and vascular repair after inflammatory vascular injury.
RhoGTPase in Vascular Disease.
Vascular Malformations
CDC42 Deletion Elicits Cerebral Vascular Malformations via Increased MEKK3-Dependent KLF4 Expression.
Defective endothelial cell migration in the absence of Cdc42 leads to capillary-venous malformations.
Vascular System Injuries
Assessment of roles for the Rho-specific guanine nucleotide dissociation inhibitor (RhoGDI) Ly-GDI in platelet function: a spatial systems approach.
Endothelial Cdc42 deficiency impairs endothelial regeneration and vascular repair after inflammatory vascular injury.
Inhibitory effect of fluvastatin on aortic intimal thickening in normocholesterolemic rabbits.
Ventilator-Induced Lung Injury
Role of Krev Interaction Trapped-1 in Prostacyclin-Induced Protection against Lung Vascular Permeability Induced by Excessive Mechanical Forces and Thrombin Receptor Activating Peptide 6.
Vesicular Stomatitis
Directed membrane transport is involved in process formation in cultured podocytes.
Ganglioside GD3 traffics from the trans-Golgi network to plasma membrane by a Rab11-independent and brefeldin A-insensitive exocytic pathway.
GTP-binding mutants of rab1 and rab2 are potent inhibitors of vesicular transport from the endoplasmic reticulum to the Golgi complex.
H-Ras Exerts Opposing Effects on Type I Interferon Responses Depending on Its Activation Status.
Identification and characterization of a novel broad spectrum virus entry inhibitor.
Phosphatidylinositol 3-phosphatase myotubularin-related protein 6 (MTMR6) is regulated by small GTPase Rab1B in the early secretory and autophagic pathways.
Phosphatidylinositol 4-kinasebeta is critical for functional association of rab11 with the Golgi complex.
Virus Diseases
Antiviral phagocytosis is regulated by a novel Rab-dependent complex in shrimp penaeus japonicus.
Characterization of a Rab GTPase up-regulated in the shrimp Peneaus japonicus by virus infection.
Disentangling the role of PI3K/Akt, Rho GTPase and the actin cytoskeleton on dengue virus infection.
Dissecting the role of a plant-specific Rab5 small GTPase NbRabF1 in Bamboo mosaic virus infection.
Efficient entry of budded virions of Autographa californica multiple nucleopolyhedrovirus into Spodoptera frugiperda cells is dependent on dynamin, Rab5, and Rab11.
Equine Alphaherpesviruses Require Activation of the Small GTPases Rac1 and Cdc42 for Intracellular Transport.
H-Ras Exerts Opposing Effects on Type I Interferon Responses Depending on Its Activation Status.
H-Ras gene takes part to the host immune response to COVID-19.
HIV signaling through CD4 and CCR5 activates Rho family GTPases that are required for optimal infection of primary CD4+ T cells.
Human Papillomavirus DNA and Oncogene Alterations in Colorectal Tumors.
Intracellular distribution and transcriptional regulation of Atlantic salmon (Salmo salar) Rab5c, 7a and 27a homologs by immune stimuli.
Management of two cases of recurrent anal carcinoma.
MIF inhibits monocytic movement through a non-canonical receptor and disruption of temporal Rho GTPase activities in U-937 cells.
NbRABG3f, a member of Rab GTPase, is involved in Bamboo mosaic virus infection in Nicotiana benthamiana.
Nuclear accumulation of globular actin as a cellular senescence marker.
Rab13 Is Involved in the Entry Step of Hepatitis C Virus Infection.
Rab18 Facilitates Dengue Virus Infection by Targeting Fatty Acid Synthase to Sites of Viral Replication.
Rab27b regulates extracellular vesicle production in cells infected with Kaposi's sarcoma-associated herpesvirus to promote cell survival and persistent infection.
Rab5 and Rab11 Are Required for Clathrin-Dependent Endocytosis of Japanese Encephalitis Virus in BHK-21 Cells.
Rac1 and PAK1 are upstream of IKK-epsilon and TBK-1 in the viral activation of interferon regulatory factor-3.
Role of the small GTPase Rab27a during herpes simplex virus infection of oligodendrocytic cells.
Roles of small GTPase Rac1 in the regulation of actin cytoskeleton during dengue virus infection.
Suppression of PmRab7 by dsRNA inhibits WSSV or YHV infection in shrimp.
The deubiquitylase USP33 discriminates between RALB functions in autophagy and innate immune response.
Vision Disorders
ARL13B, a Joubert Syndrome-Associated Protein, Is Critical for Retinogenesis and Elaboration of Mouse Photoreceptor Outer Segments.
Vitamin D Deficiency
K-ras mutations in 1,2-dimethylhydrazine-induced colonic tumors: effects of supplemental dietary calcium and vitamin D deficiency.
Vitiligo
Autoantigens in Vitiligo Identified by the Serological Selection of a Phage-Displayed Melanocyte cDNA Expression Library.
Melanocyte Precursors in the Hair Follicle Bulge of Repigmented Vitiligo Skin Are Controlled by RHO-GTPase, KCTD10, and CTNNB1 Signaling.
von Hippel-Lindau Disease
Alterations of tumor suppressor genes and the H-ras oncogene in oral squamous cell carcinoma.
Wasting Syndrome
Reciprocal Regulation of Glycolysis-Driven Th17 Pathogenicity and Regulatory T Cell Stability by Cdc42.
Werner Syndrome
Contribution of Cdc42 to cholesterol efflux in fibroblasts from Tangier disease and Werner syndrome.
Defective cholesterol efflux in Werner syndrome fibroblasts and its phenotypic correction by Cdc42, a RhoGTPase.
Whooping Cough
A link between Cdc42 and syntaxin is involved in mastoparan-stimulated insulin release.
Antiproliferative property of sphingosine 1-phosphate in rat hepatocytes involves activation of Rho via Edg-5.
Calcium mobilization and protease-activated receptor cleavage after thrombin stimulation in motor neurons.
Characterization of a novel subtype of human G protein-coupled receptor for lysophosphatidic acid.
Characterization of rac and cdc42 activation in chemoattractant-stimulated human neutrophils using a novel assay for active GTPases.
Deregulation of hamster fibroblast proliferation by mutated ras oncogenes is not mediated by constitutive activation of phosphoinositide-specific phospholipase C.
Effector function for RAS oncogene in interleukin-3-dependent myeloid cells involves diminished efficacy of prostaglandin E1-mediated inhibition of proliferation.
Endothelin 1 stimulates beta1Pix-dependent activation of Cdc42 through the G(salpha) pathway.
Erk1/2- and p38 MAP kinase-dependent phosphorylation and activation of cPLA2 by m3 and m2 receptors.
Flt-1-mediated down-regulation of endothelial cell proliferation through pertussis toxin-sensitive G proteins, beta gamma subunits, small GTPase CDC42, and partly by Rac-1.
KDR stimulates endothelial cell migration through heterotrimeric G protein Gq/11-mediated activation of a small GTPase RhoA.
Lysophosphatidic Acid Stimulates Ovarian Cancer Cell Migration via a Ras-MEK Kinase 1 Pathway.
Regulation of Rac and Cdc42 pathways by G(i) during lysophosphatidic acid-induced cell spreading.
Role of Rac and Cdc42 in lysophosphatidic acid-mediated cyclo-oxygenase-2 gene expression.
Somatostatin activation of mitogen-activated protein kinase via somatostatin receptor 1 (SSTR1).
Somatostatin receptor 1 (SSTR1)-mediated inhibition of cell proliferation correlates with the activation of the MAP kinase cascade: role of the phosphotyrosine phosphatase SHP-2.
The G12/13-RhoA signaling pathway contributes to efficient lysophosphatidic acid-stimulated cell migration.
The heterotrimeric G q protein-coupled angiotensin II receptor activates p21 ras via the tyrosine kinase-Shc-Grb2-Sos pathway in cardiac myocytes.
Xaliproden (SR57746A) induces 5-HT1A receptor-mediated MAP kinase activation in PC12 cells.
Zebrafish Mir antagonizes Frizzled 7-induced gastrulation defects.
Wilms Tumor
A Murine Model of K-RAS and ?-Catenin Induced Renal Tumors Expresses High Levels of E2F1 and Resembles Human Wilms Tumor.
Co-deletions of the retinoblastoma gene and Wilms' tumor gene and rearrangement of the Krev-1 gene in a human insulinoma.
Further studies on aberrant gene expression associated with arsenic-induced malignant transformation in rat liver TRL1215 cells.
Infrequency of ras, p53, WT1, or RB gene alterations in Wilms tumors.
Molecular genetic analysis of clear cell adenocarcinomas of the vagina and cervix associated and unassociated with diethylstilbestrol exposure in utero.
Wiskott-Aldrich Syndrome
A conserved amphipathic helix in WASP/Scar proteins is essential for activation of Arp2/3 complex.
A dock and coalesce mechanism driven by hydrophobic interactions governs Cdc42 binding with its effector protein ACK.
A novel actin bundling/filopodium-forming domain conserved in insulin receptor tyrosine kinase substrate p53 and missing in metastasis protein.
A novel neural Wiskott-Aldrich syndrome protein (N-WASP) binding protein, WISH, induces Arp2/3 complex activation independent of Cdc42.
Activation by Cdc42 and PIP(2) of Wiskott-Aldrich syndrome protein (WASp) stimulates actin nucleation by Arp2/3 complex.
Activation of compensatory pathways via Rac2 in the absence of the Cdc42 effector Wiskott-Aldrich syndrome protein in Dendritic cells.
AKAP350 interaction with cdc42 interacting protein 4 at the Golgi apparatus.
An actin-based protrusion originating from a podosome-enriched region initiates macrophage fusion.
An electrostatic steering mechanism of Cdc42 recognition by Wiskott-Aldrich syndrome proteins.
ATP-binding cassette transporter-1 induces rearrangement of actin cytoskeletons possibly through Cdc42/N-WASP.
Autoinhibition and activation mechanisms of the Wiskott-Aldrich syndrome protein.
Biochemical properties and inhibitors of (N-)WASP.
C(16)-Ceramide-induced F-actin Regulation Stimulates Mouse Embryonic Stem Cell Migration: Involvement of N-WASP/Cdc42/Arp2/3 complex and cofilin-1/?-actinin.
Caenorhabditis elegans wsp-1 regulation of synaptic function at the neuromuscular junction.
Cdc42 and the actin-related protein/neural Wiskott-Aldrich syndrome protein network mediate cellular invasion by Cryptosporidium parvum.
Cdc42 antagonizes Rho1 activity at adherens junctions to limit epithelial cell apical tension.
Cdc42 in actin dynamics: An ordered pathway governed by complex equilibria and directional effector handover.
Cdc42 is a key regulator of B cell differentiation and is required for antiviral humoral immunity.
Cdc42 Regulates Fc{gamma} Receptor-mediated Phagocytosis through the Activation and Phosphorylation of WASP and N-WASP.
Cdc42, Rac1, and the Wiskott-Aldrich syndrome protein are involved in the cytoskeletal regulation of B lymphocytes.
Cdc42-interacting protein 4 binds to huntingtin: neuropathologic and biological evidence for a role in Huntington's disease.
Characterization of the interactions between the small GTPase Cdc42 and its GTPase-activating proteins and putative effectors. Comparison of kinetic properties of Cdc42 binding to the Cdc42-interactive domains.
Coiling phagocytosis of Borrelia burgdorferi by primary human macrophages is controlled by CDC42Hs and Rac1 and involves recruitment of Wiskott-Aldrich syndrome protein and Arp2/3 complex.
Contingent phosphorylation/dephosphorylation provides a mechanism of molecular memory in WASP.
Contrasting cytoskeletal regulation of MHC class II peptide presentation by human B cells or dendritic cells.
Crosstalk between WIP and Rho family GTPases.
Dedicator of cytokinesis 8 interacts with talin and wiskott-Aldrich syndrome protein to regulate NK cell cytotoxicity.
Deleted in colorectal cancer binding netrin-1 mediates cell substrate adhesion and recruits Cdc42, Rac1, Pak1, and N-WASP into an intracellular signaling complex that promotes growth cone expansion.
Determination of in Vivo Dissociation Constant, KD, of Cdc42-Effector Complexes in Live Mammalian Cells Using Single Wavelength Fluorescence Cross-correlation Spectroscopy.
Direct interaction of the Wiskott-Aldrich syndrome protein with the GTPase Cdc42.
Disease mechanism: unravelling Wiskott-Aldrich syndrome.
DOCK8 immune deficiency as a model for primary cytoskeletal dysfunction.
E-cadherin-mediated cell-cell attachment activates Cdc42.
EFC/F-BAR proteins and the N-WASP-WIP complex induce membrane curvature-dependent actin polymerization.
Essential role of neural Wiskott-Aldrich syndrome protein in neurite extension in PC12 cells and rat hippocampal primary culture cells.
Exploring the mechanism of flexible biomolecular recognition with single molecule dynamics.
FBP11 regulates nuclear localization of N-WASP and inhibits N-WASP-dependent microspike formation.
Fyn and PTP-PEST-mediated regulation of Wiskott-Aldrich syndrome protein (WASp) tyrosine phosphorylation is required for coupling T cell antigen receptor engagement to WASp effector function and T cell activation.
Ganoderiol A-enriched extract suppresses migration and adhesion of MDA-MB-231 cells by inhibiting FAK-SRC-paxillin cascade pathway.
Genetically encoded photoswitching of actin assembly through the Cdc42-WASP-Arp2/3 complex pathway.
Global disruption of the WASP autoinhibited structure on Cdc42 binding. Ligand displacement as a novel method for monitoring amide hydrogen exchange.
Identification of host proteins involved in rickettsial invasion of tick cells.
Insulin-increased prolactin gene expression requires actin treadmilling: potential role for p21 activated kinase.
Intersectin 1L guanine nucleotide exchange activity is regulated by adjacent src homology 3 domains that are also involved in endocytosis.
Investigation of the Interaction between Cdc42 and Its Effector TOCA1: HANDOVER OF Cdc42 TO THE ACTIN REGULATOR N-WASP IS FACILITATED BY DIFFERENTIAL BINDING AFFINITIES.
Isolation of a NCK-associated kinase, PRK2, an SH3-binding protein and potential effector of Rho protein signaling.
Itk functions to control actin polymerization at the immune synapse through localized activation of Cdc42 and WASP.
Lassa Virus Cell Entry via Dystroglycan Involves an Unusual Pathway of Macropinocytosis.
Levels of Rabs and WAVE family proteins associated with translocation of GLUT4 to the cell surface in endometria from hyperinsulinemic PCOS women.
Loss of the F-BAR protein CIP4 reduces platelet production by impairing membrane-cytoskeleton remodeling.
Mangiferin inhibits cell migration and invasion through Rac1/WAVE2 signalling in breast cancer.
Mechanism of N-WASP activation by CDC42 and phosphatidylinositol 4, 5-bisphosphate.
Mechanisms of host cell exit by the intracellular bacterium Chlamydia.
Microtubule-dependent formation of podosomal adhesion structures in primary human macrophages.
miR-142-3p Reduces the Size, Migration, and Contractility of Endometrial and Endometriotic Stromal Cells by Targeting Integrin- and Rho GTPase-Related Pathways That Regulate Cytoskeletal Function.
Morphology of the lamellipodium and organization of actin filaments at the leading edge of crawling cells.
N-WASP activation by a beta1-integrin-dependent mechanism supports PI3K-independent chemotaxis stimulated by urokinase-type plasminogen activator.
N-WASP regulates extension of filopodia and processes by oligodendrocyte progenitors, oligodendrocytes, and Schwann cells-implications for axon ensheathment at myelination.
Nck and phosphatidylinositol 4,5-bisphosphate synergistically activate actin polymerization through the N-WASP-Arp2/3 pathway.
Neural Wiskott-Aldrich syndrome protein is implicated in the actin-based motility of Shigella flexneri.
Phosphoinositides and membrane curvature switch the mode of actin polymerization via selective recruitment of toca-1 and Snx9.
Phosphorylation of WASP by the Cdc42-associated kinase ACK1: dual hydroxyamino acid specificity in a tyrosine kinase.
Phosphorylation of WAVE downstream of mitogen-activated protein kinase signaling.
Platelet lamellipodium formation is not required for thrombus formation and stability.
Profilin enhances Cdc42-induced nucleation of actin polymerization.
Progressive decline of T and B cell numbers and function in a patient with CDC42 deficiency.
Protein-tyrosine kinase and GTPase signals cooperate to phosphorylate and activate Wiskott-Aldrich syndrome protein (WASP)/neuronal WASP.
Rapid Actions of Plasma Membrane Estrogen Receptors Regulate Motility of Mouse Embryonic Stem Cells through a Profilin-1/Cofilin-1-Directed Kinase Signaling Pathway.
Rapid association of cytoskeletal remodeling proteins with the developing phagosomes of human neutrophils.
Rapid WAVE dynamics in dendritic spines of cultured hippocampal neurons is mediated by actin polymerization.
Rational design of genetically encoded fluorescence resonance energy transfer-based sensors of cellular Cdc42 signaling.
Regulation of Cdc42 and its effectors in epithelial morphogenesis.
Regulation of gastric smooth muscle contraction via Ca2+-dependent and Ca2+-independent actin polymerization.
Regulation of podosome dynamics by WASp phosphorylation: implication in matrix degradation and chemotaxis in macrophages.
Rho family GTPase Cdc42 is essential for the actin-based motility of Shigella in mammalian cells.
Rho kinase collaborates with p21-activated kinase to regulate actin polymerization and contraction in airway smooth muscle.
Role of Rac1/WAVE2 Signaling in Mediating the Inhibitory Effects of ?-Tocotrienol on Mammary Cancer Cell Migration and Invasion.
Roles of rho GTPases in intracellular transport and cellular transformation.
Signalling to actin: the Cdc42-N-WASP-Arp2/3 connection.
Spatial control of actin-based motility through plasmalemmal PtdIns(4,5)P2-rich raft assemblies.
Structure of Cdc42 in complex with the GTPase-binding domain of the 'Wiskott-Aldrich syndrome' protein.
Teneurin-4 promotes cellular protrusion formation and neurite outgrowth through focal adhesion kinase signaling.
The adapter protein CrkII regulates neuronal Wiskott-Aldrich syndrome protein, actin polymerization, and tension development during contractile stimulation of smooth muscle.
The Cdc42 effector IRSp53 generates filopodia by coupling membrane protrusion with actin dynamics.
The Cdc42-selective GAP Rich regulates postsynaptic development and retrograde BMP transsynaptic signaling.
The Cdc42/Rac interactive binding region motif of the Wiskott Aldrich syndrome protein (WASP) is necessary but not sufficient for tight binding to Cdc42 and structure formation.
The cell division control protein 42-Src family kinase-neural Wiskott-Aldrich syndrome protein pathway regulates human proplatelet formation.
The dock-and-coalesce mechanism for the association of a WASP disordered region with the Cdc42 GTPase.
The interaction between Cdc42 and WASP is required for SDF-1-induced T-lymphocyte chemotaxis.
The intersectin 2 adaptor links Wiskott Aldrich Syndrome protein (WASp)-mediated actin polymerization to T cell antigen receptor endocytosis.
The mechanism of CSF-1-induced Wiskott-Aldrich syndrome protein activation in vivo: a role for phosphatidylinositol 3-kinase and Cdc42.
The nucleotide switch in Cdc42 modulates coupling between the GTPase-binding and allosteric equilibria of Wiskott-Aldrich syndrome protein.
The Rho GTPase Cdc42 Is Essential for the Activation and Function of Mature B Cells.
The Role of Rho-GTPases and actin polymerization during Macrophage Tunneling Nanotube Biogenesis.
The small GTPase Cdc42 modulates the number of exocytosis-competent dense-core vesicles in PC12 cells.
The small GTPase Cdc42 regulates actin polymerization and tension development during contractile stimulation of smooth muscle.
The type III TGF? receptor regulates filopodia formation via a Cdc42-mediated IRSp53-N-WASP interaction in epithelial cells.
Thromboxane-induced actin polymerization in hypoxic neonatal pulmonary arterial myocytes involves Cdc42 signaling.
Two GTPases, Cdc42 and Rac, bind directly to a protein implicated in the immunodeficiency disorder Wiskott-Aldrich syndrome.
Two pathways through Cdc42 couple the N-formyl receptor to actin nucleation in permeabilized human neutrophils.
Tyrosine phosphorylation of the Wiskott-Aldrich syndrome protein by Lyn and Btk is regulated by CDC42.
WAVE2 deficiency reveals distinct roles in embryogenesis and Rac-mediated actin-based motility.
WIP participates in actin reorganization and ruffle formation induced by PDGF.
Wiskott-Aldrich syndrome protein (WASp) and N-WASp are involved in the regulation of NK-cell migration upon NKG2D activation.
Wiskott-Aldrich syndrome protein induces actin clustering without direct binding to Cdc42.
Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization.
Yersinia enterocolitica invasin triggers phagocytosis via beta1 integrins, CDC42Hs and WASp in macrophages.
Xeroderma Pigmentosum
Polymorphisms in DNA repair and metabolic genes in bladder cancer.
Zika Virus Infection
The small GTPase RAB1B promotes antiviral innate immunity by interacting with TNF receptor-associated factor 3 (TRAF3).