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Information on EC 3.6.5.2 - small monomeric GTPase and Organism(s) Mus musculus and UniProt Accession Q9QUI0

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IUBMB Comments
A family of about 50 enzymes with a molecular mass of 21 kDa that are distantly related to the alpha-subunit of heterotrimeric G-protein GTPase (EC 3.6.5.1). They are involved in cell-growth regulation (Ras subfamily), membrane vesicle traffic and uncoating (Rab and ARF subfamilies), nuclear protein import (Ran subfamily) and organization of the cytoskeleton (Rho and Rac subfamilies).
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Mus musculus
UNIPROT: Q9QUI0
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Word Map
The taxonomic range for the selected organisms is: Mus musculus
The enzyme appears in selected viruses and cellular organisms
Synonyms
k-ras, cdc42, h-ras, small gtpase, ef-tu, rho gtpase, rab11, rab3a, rab27a, rap1a, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
small GTPase
-
ADP-ribosylation factor 6
UniProt
Cdc42
GTP-phosphohydrolase
-
-
-
-
GTPase
-
-
-
-
guanine triphosphatase
-
-
-
-
guanosine 5'-triphosphatase
-
-
-
-
guanosine triphosphatase
-
-
-
-
M-Ras
-
-
monomeric G protein
-
-
Rab GTPase
-
-
Rab18
-
-
Rab23
-
-
Rab27a GTPase
-
-
Rab38
-
-
Rac GTPase
-
-
Rac1 GTPase
-
-
Rac3
-
isoform
Rac4
-
isoform
Ral GTPase
-
-
RalA
-
-
Rap GTPase
-
-
Ras GTPase
-
-
Ras proximity 1
-
Ras related GTPase Rap
-
-
Ras-associated protein 1
-
-
Rho GTPase
-
-
Rho1
-
Rho1 is important for the localization of the Sec3 component of the exocyst complex
Rho3
-
Rho3 is a direct regulator of exocytosis
RhoH
initially named translation three four, RhoH is a GTPase-deficient so-called atypical Rho GTPase, RhoH is only found in vertebrates
ribosomal GTPase
-
-
-
-
small GTPase
small GTPase ARF6
-
-
small GTPase Rab21
-
-
small GTPase Rab27b
-
-
small nuclear GTPase Ran
-
-
small Rho GTPase
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phosphorous acid anhydride hydrolysis
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
GTP phosphohydrolase (cell-regulating)
A family of about 50 enzymes with a molecular mass of 21 kDa that are distantly related to the alpha-subunit of heterotrimeric G-protein GTPase (EC 3.6.5.1). They are involved in cell-growth regulation (Ras subfamily), membrane vesicle traffic and uncoating (Rab and ARF subfamilies), nuclear protein import (Ran subfamily) and organization of the cytoskeleton (Rho and Rac subfamilies).
CAS REGISTRY NUMBER
COMMENTARY hide
9059-32-9
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
GTP + H2O
GDP + phosphate
show the reaction diagram
GTP + H2O
GDP + phosphate
show the reaction diagram
guanosine 5'-O-(3-thiotriphosphate) + H2O
guanosine 5'-O-diphosphate + thiophosphate
show the reaction diagram
-
-
-
-
?
additional information
?
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
GTP + H2O
GDP + phosphate
show the reaction diagram
GTP + H2O
GDP + phosphate
show the reaction diagram
additional information
?
-
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
NSC23766
Rap1GAP1
-
a GTPase-activating protein that inhibits Rap1 activity
-
additional information
-
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
TGF-beta1
TGF-beta1 activates Rap1 through cAMP and Epac1/Epac2. 2',5-dideoxyadenosine is an inhibitor of adenlyate cyclase on Rap1 activity
-
ACAP3
aGTPase-activating protein (GAP) specific to small GTPase Arf6. ACAP3 is involved in neuronal migration in the developing cerebral cortex of mice, regulation mechanism, detailed overview. ACAP3 is abundantly expressed in the developing cerebral cortex. GAP activity of ACAP3 is required for neuronal migration. Knockdown of ACAP3 in the developing cortical neurons of mice in utero significantly abrogates neuronal migration in the cortical layer, which is restored by ectopic expression of wild-type ACAP3, but not by its GAP-inactive mutant
-
Calcium
-
-
cAMP
-
-
cytotoxic necrotizing factor 1
activation of Rho proteins by the cytotoxic necrotizing factor 1 (CNF1) from Escherichia coli, while the isomeric cytotoxicnecrotizing factor from Yersinia pseudotuberculosis (CNFy) drives GTP-loading of basal RhoB but fails to cause activation of the rhoB promoter and thus its expression. CNF1 inhibits cytokinesis and induces the formation of bi-nucleated (tetraploid) cells. Cytotoxic-necrotizing factors encompass a class of auto-transporter toxins produced by Escherichia coli (CNF1-3) or Yersinia pseudotuberculosis (CNFy). CNF1 specifically deamidates RhoA. CNF1-induced RhoB response depends on the deamidation of Rho proteins
-
diacylglycerol
-
-
geranylgeranyl transferase I
-
RhoA is activated by geranylgeranylation, which promotes its membrane anchoring, the geranylgeranyl transferase I inhibitor GGTI-2166to is used to inhibit geranylgeranylation
-
guanine nucleotide exchange factor Epac
-
specifically increases Rap1 activity
-
Insulin
-
RalA is activated upon insulin stimulation in a dose-dependent manner
-
lipopolysaccharide
Rap2a is activated by lipopolysaccharide in macrophages. In contrast to mRNA levels, Rap2a protein levels are increased after lipopolysaccharide treatments of macrophages
TGF-beta1
TGF-beta1 activates Rap1 through cAMP and Epac1/Epac2. 2',5-dideoxyadenosine is an inhibitor of adenlyate cyclase on Rap1 activity
-
additional information
-
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
UniProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
constitutively active RhoA in primary culture of spinal motoneurons
Manually annotated by BRENDA team
-
tumor-induced dysregulation of endocytic activity of dendritic cells is mediated by reduced activity of several members of the small Rho GTPase family
Manually annotated by BRENDA team
-
tumor-induced dysregulation of endocytic activity of dendritic cells is mediated by reduced activity of several members of the small Rho GTPase family
Manually annotated by BRENDA team
-
high expression of Rap1b
Manually annotated by BRENDA team
-
in the adult mouse brain, Rab23 is detected in betaIII tubulin positive neuronal cell bodies and are most prominent in cortex, hypothalamus and the cerebellum
Manually annotated by BRENDA team
-
Ras is detected in medullary endothelial cells, medullary interstitial cells, cortical interstitial cells and glomerular endothelial cells. Ras plays a role in renal fibrosis
Manually annotated by BRENDA team
-
ARF6 is an essential component in the signaling pathway coupling hepatocyte growth factor signaling to hepatic cord formation
Manually annotated by BRENDA team
-
tumor-induced dysregulation of endocytic activity of dendritic cells is mediated by reduced activity of several members of the small Rho GTPase family
Manually annotated by BRENDA team
-
Rac1 activity serves as a regulator of cell senescence through modulation of cellular ROS, genomic stability, and p53 activity
Manually annotated by BRENDA team
primary cells
Manually annotated by BRENDA team
-
tumor-induced dysregulation of endocytic activity of dendritic cells is mediated by reduced activity of several members of the small Rho GTPase family
Manually annotated by BRENDA team
RhoH is expressed strongest in T-lymphocytes and acts as a positive regulatory factor for thymocyte selection and T-cell receptor signalling
Manually annotated by BRENDA team
additional information
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
-
membrane, associated with
Manually annotated by BRENDA team
additional information
-
RalA localizes independently of intracellular insulin granules
-
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
expression of constitutively active RhoA in primary culture of spinal motoneurons also drastically reduces high-voltage-activated Ca2+ current amplitude
metabolism
high-voltage-activated Ca2+ channels are known regulators of synapse formation and transmission and play fundamental roles in neuronal pathophysiology. Small GTPases of Rho and RGK families, via their action on both cytoskeleton and Ca2+ channels are key molecules for these processes
physiological function
evolution
malfunction
metabolism
physiological function
additional information
-
activation of Rap1 by Epac1 leads to increased integrin activity and adhesion of endothelial progenitor cells, CD34+ hematopoietic progenitor cells and mesenchylmal stem cells, which show increased homing and neovascularization capabilities
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
RHOA_MOUSE
193
0
21782
Swiss-Prot
other Location (Reliability: 2)
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
crystallization of M-ras in the GDP-bound and guanosine 5'-(beta,gamma-imido)triphosphate-bound forms, hanging-drop vapour diffusion method at 20°C using the reservoir solution containing 20% w/v polyethylene glycol 8000 and 50 mM potassium phosphate at a protein concentration of 10 mg/ml
-
hanging drop vapour diffusion method, using 1.0 M sodium citrate trihydrate, 0.1 M sodium cacodylate, at pH 6.5
-
hanging-drop vapour-diffusion method
-
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
AS28N
-
the mutant significantly inhibits KCl-induced insulin secretion but has no significant effect on glucose/carbachol-and glucose/KCl-induced insulin secretion despite an inhibitory trend
D57N
-
the dominant negative Rac GTPase mutation does not only inhibit Rac1, Rac2, and Rac3 activities, but may also inhibit Cdc42
E78L
-
inactive
E78L/C123S/C188S
-
the mutant may modulate effector recognition by forming an intramolecular disulfide bridge
G12V
-
constitutively active Rac mutant
G23V
-
RalA mutant with higher affinity for GTP
N122I
-
mutant with nucleotide deficiency
S22N
-
mutant with constitutive GDP binding deficiency
T17N
-
dominant negative Rac mutant
additional information
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
glutathione-Sepharose 4B bead chromatography
-
glutathione-Sepharose bead chromatography
-
GppNHp-bound Rab27a in complex with the Rab27-binding domain of exophilin4/Slp2-a effector, glutathione Sepharose 4B resin chromatography and Superdex-75 gel filtration
-
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
heterologous expression of RhoA in Xenopus laevis oocytes. Expression of constitutively active RhoA in primary culture of spinal motoneurons also drastically reduces high-voltage-activated Ca2+ current amplitude
recombinant expression of GST-tagged RapI protein
analysis of rhoB mRNA level by semi-quantitative real-time RT-PCR
expressed in Escherichia coli BL21 cells
-
expressed in Escherichia coli BL21(DE3) LysS cells. Three crystal structures of Rab27b-GDP were solved in three different space groups: P6522, C2 and P212121
-
expressed in Escherichia coli strain BL21(DE3)-LysS
-
genes rap1a and rap1b, genetic models
-
quantitative RT-PCR enzyme expression analysis, cotransfection of the NF-kappaB reporter with TLR2, TLR3, and TLR4, CD14, MD2 and Rap2a encoding plasmids into HEK-293 cells, and further treating the cells with the TLR ligands
recombinant expression of GST-tagged RapI protein
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
8CPT-2Me-cAMP suppresses GTP-RhoA levels
si-Rap1 augments GTP-RhoA levels and cell migration. si-RNAs of Epac1 and Epac2 reduced GTP-Rap1 levels leading to promotion of GTP-RhoA levels. si-RNA of ARAP3 (Rap-dependent RhoGAP) increased GTP-RhoA level and cell migration
expression levels of Rap2a in macrophages might be tightly regulated to avoid unbalanced immune response
putative activator TLR-inducible Ras guanine exchange factor RasGEF1b is sufficient to induce, it is not fully required for Rap2a activation. In contrast to mRNA levels, Rap2a protein levels are increased after lipopolysaccharide treatments of macrophages
RhoB is the only member of the Rho subfamily of small GTPases, which is classified as an immediateearly gene product. RhoB is up-regulated in response to growth factors as well as cytotoxic and geno-toxic agents. Clostridial glucosylating toxins evoke pronounced RhoB expression, based on the inactivation of Rho/Ras proteins. Long lasting expression of RhoB in cultured cells upon activation of Rho proteins by the cytotoxic necrotizing factor 1 (CNF1) from Escherichia coli. CNF1-induced RhoB expression in primary and immortalized NIH3T3 fibroblasts. Deamidase-deficient CNF1-C866S fails to activate the rhoB promoter, CNF1-C866S only faintly induces expression of rhoB mRNA and RhoB protein. Critical role of Rac1 in CNF1-induced RhoB expression, overview
si-RNAs of Epac1 and Epac2 reduced GTP-Rap1 levels
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
medicine
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Ye, M.; Shima, F.; Muraoka, S.; Liao, J.; Okamoto, H.; Yamamoto, M.; Tamura, A.; Yagi, N.; Ueki, T.; Kataoka, T.
Crystal structure of M-Ras reveals a GTP-bound off state conformation of Ras family small GTPases
J. Biol. Chem.
280
31267-31275
2005
Mus musculus
Manually annotated by BRENDA team
Guo, A.; Wang, T.; Ng, E.L.; Aulia, S.; Chong, K.H.; Teng, F.Y.; Wang, Y.; Tang, B.L.
Open brain gene product Rab23: expression pattern in the adult mouse brain and functional characterization
J. Neurosci. Res.
83
1118-1127
2006
Mus musculus
Manually annotated by BRENDA team
Chavas, L.M.; Torii, S.; Kamikubo, H.; Kawasaki, M.; Ihara, K.; Kato, R.; Kataoka, M.; Izumi, T.; Wakatsuki, S.
Structure of the small GTPase Rab27b shows an unexpected swapped dimer
Acta Crystallogr. Sect. D
63
769-779
2007
Mus musculus
Manually annotated by BRENDA team
Liao, J.; Shima, F.; Araki, M.; Ye, M.; Muraoka, S.; Sugimoto, T.; Kawamura, M.; Yamamoto, N.; Tamura, A.; Kataoka, T.
Two conformational states of Ras GTPase exhibit differential GTP-binding kinetics
Biochem. Biophys. Res. Commun.
369
327-332
2008
Homo sapiens, Mus musculus, Suberites domuncula (A1XKQ5), Suberites domuncula (A1XKQ6), Suberites domuncula (A1XKQ7), Suberites domuncula (A1XKQ8), Suberites domuncula (A1XKQ9), Suberites domuncula (A1XKR0), Suberites domuncula (A1XKR1), Suberites domuncula (A1XKR2), Suberites domuncula (A1XKR3), Suberites domuncula (A1XKR5), Suberites domuncula (A1XKR6), Suberites domuncula (A1XKR7), Suberites domuncula (A1XKR8), Suberites domuncula (A1XKR9), Suberites domuncula (A1XKS0), Suberites domuncula (A1XKS1), Suberites domuncula (A1XKS2), Suberites domuncula (A1XKS3), Suberites domuncula (A1XKS4), Suberites domuncula (A1XKS5), Suberites domuncula (A1XKS6), Suberites domuncula (A1XKS7), Suberites domuncula (A1XKS8), Suberites domuncula (A1XKS9), Suberites domuncula (A1XKT0), Suberites domuncula (A1XKT1), Suberites domuncula (A1XKT2), Suberites domuncula (A1XKT3), Suberites domuncula (A1XKT4), Suberites domuncula (A1XKT5), Suberites domuncula (A1XKT6), Suberites domuncula (A1XKT7), Suberites domuncula (A1XKT8), Suberites domuncula (A1XKT9), Suberites domuncula (A1XKU0), Suberites domuncula (A1XKU1), Suberites domuncula (A1XKU2), Suberites domuncula (A1XKU3), Suberites domuncula (A1XKU4), Suberites domuncula (A1XKU5), Suberites domuncula (O97342), Suberites domuncula (Q4H115), Suberites domuncula (Q4H116)
Manually annotated by BRENDA team
Martinez-Salgado, C.; Rodriguez-Pena, A.B.; Lopez-Novoa, J.M.
Involvement of small Ras GTPases and their effectors in chronic renal disease
Cell. Mol. Life Sci.
65
477-492
2008
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Debidda, M.; Williams, D.A.; Zheng, Y.
Rac1 GTPase regulates cell genomic stability and senescence
J. Biol. Chem.
281
38519-38528
2006
Mus musculus
Manually annotated by BRENDA team
Pellinen, T.; Arjonen, A.; Vuoriluoto, K.; Kallio, K.; Fransen, J.A.; Ivaska, J.
Small GTPase Rab21 regulates cell adhesion and controls endosomal traffic of beta1-integrins
J. Cell Biol.
173
767-780
2006
Mus musculus
Manually annotated by BRENDA team
Tourkova, I.L.; Shurin, G.V.; Wei, S.; Shurin, M.R.
Small rho GTPases mediate tumor-induced inhibition of endocytic activity of dendritic cells
J. Immunol.
178
7787-7793
2007
Mus musculus
Manually annotated by BRENDA team
Shurin, G.V.; Tourkova, I.L.; Shurin, M.R.
Low-dose chemotherapeutic agents regulate small Rho GTPase activity in dendritic cells
J. Immunother.
31
491-499
2008
Mus musculus
Manually annotated by BRENDA team
Goldfinger, L.E.
Choose your own path: specificity in Ras GTPase signaling
Mol. Biosyst.
4
293-299
2008
Mus musculus
Manually annotated by BRENDA team
Suzuki, T.; Kanai, Y.; Hara, T.; Sasaki, J.; Sasaki, T.; Kohara, M.; Maehama, T.; Taya, C.; Shitara, H.; Yonekawa, H.; Frohman, M.A.; Yokozeki, T.; Kanaho, Y.
Crucial role of the small GTPase ARF6 in hepatic cord formation during liver development
Mol. Cell. Biol.
26
6149-6156
2006
Mus musculus
Manually annotated by BRENDA team
Clarke, P.R.; Zhang, C.
Spatial and temporal coordination of mitosis by Ran GTPase
Nat. Rev. Mol. Cell Biol.
9
464-477
2008
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Chavas, L.M.; Ihara, K.; Kawasaki, M.; Kato, R.; Izumi, T.; Wakatsuki, S.
Purification, crystallization and preliminary X-ray crystallographic analysis of Rab27a GTPase in complex with exophilin4/Slp2-a effector
Acta Crystallogr. Sect. F
64
599-601
2008
Mus musculus
Manually annotated by BRENDA team
Osanai, K.; Oikawa, R.; Higuchi, J.; Kobayashi, M.; Tsuchihara, K.; Iguchi, M.; Jongsu, H.; Toga, H.; Voelker, D.R.
A mutation in Rab38 small GTPase causes abnormal lung surfactant homeostasis and aberrant alveolar structure in mice
Am. J. Pathol.
173
1265-1274
2008
Mus musculus
Manually annotated by BRENDA team
Carmona, G.; Goettig, S.; Orlandi, A.; Scheele, J.; Baeuerle, T.; Jugold, M.; Kiessling, F.; Henschler, R.; Zeiher, A.M.; Dimmeler, S.; Chavakis, E.
Role of the small GTPase Rap1 for integrin activity regulation in endothelial cells and angiogenesis
Blood
113
488-497
2009
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Fueller, F.; Kubatzky, K.F.
The small GTPase RhoH is an atypical regulator of haematopoietic cells
Cell Commun. Signal.
6
6-6
2008
Homo sapiens (Q15669), Homo sapiens, Mus musculus (Q9D3G9), Mus musculus
Manually annotated by BRENDA team
Fuchs, S.; Herzog, D.; Sumara, G.; Buechmann-Moller, S.; Civenni, G.; Wu, X.; Chrostek-Grashoff, A.; Suter, U.; Ricci, R.; Relvas, J.B.; Brakebusch, C.; Sommer, L.
Stage-specific control of neural crest stem cell proliferation by the small Rho GTPases Cdc42 and Rac1
Cell Stem cell
4
236-247
2009
Mus musculus
Manually annotated by BRENDA team
Savina, A.; Peres, A.; Cebrian, I.; Carmo, N.; Moita, C.; Hacohen, N.; Moita, L.F.; Amigorena, S.
The small GTPase Rac2 controls phagosomal alkalinization and antigen crosspresentation selectively in CD8+ dendritic cells
Immunity
30
544-555
2009
Mus musculus
Manually annotated by BRENDA team
Lopez, J.A.; Kwan, E.P.; Xie, L.; He, Y.; James, D.E.; Gaisano, H.Y.
The RalA GTPase is a central regulator of insulin exocytosis from pancreatic islet beta cells
J. Biol. Chem.
283
17939-17945
2008
Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Yoshida, T.; Clark, M.F.; Stern, P.H.
The small GTPase RhoA is crucial for MC3T3-E1 osteoblastic cell survival
J. Cell. Biochem.
106
896-902
2009
Mus musculus
Manually annotated by BRENDA team
Martin, S.; Parton, R.G.
Characterization of Rab18, a lipid droplet-associated small GTPase
Methods Enzymol.
438
109-129
2008
Mus musculus
Manually annotated by BRENDA team
Williams, D.A.; Zheng, Y.; Cancelas, J.A.
Rho GTPases and regulation of hematopoietic stem cell localization
Methods Enzymol.
439
365-393
2008
Mus musculus
Manually annotated by BRENDA team
Haditsch, U.; Leone, D.P.; Farinelli, M.; Chrostek-Grashoff, A.; Brakebusch, C.; Mansuy, I.M.; McConnell, S.K.; Palmer, T.D.
A central role for the small GTPase Rac1 in hippocampal plasticity and spatial learning and memory
Mol. Cell. Neurosci.
41
409-419
2009
Mus musculus
Manually annotated by BRENDA team
Ji, P.; Jayapal, S.R.; Lodish, H.F.
Enucleation of cultured mouse fetal erythroblasts requires Rac GTPases and mDia2
Nat. Cell Biol.
10
314-321
2008
Mus musculus
Manually annotated by BRENDA team
Wu, H.; Rossi, G.; Brennwald, P.
The ghost in the machine: small GTPases as spatial regulators of exocytosis
Trends Cell Biol.
18
397-404
2008
Mus musculus
Manually annotated by BRENDA team
Jeyaraj, S.C.; Unger, N.T.; Chotani, M.A.
Rap1 GTPases: an emerging role in the cardiovasculature
Life Sci.
88
645-652
2011
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Huelsenbeck, S.C.; Roggenkamp, D.; May, M.; Huelsenbeck, J.; Brakebusch, C.; Rottner, K.; Ladwein, M.; Just, I.; Fritz, G.; Schmidt, G.; Genth, H.
Expression and cytoprotective activity of the small GTPase RhoB induced by the Escherichia coli cytotoxic necrotizing factor 1
Int. J. Biochem. Cell Biol.
45
1767-1775
2013
Homo sapiens (P62745), Mus musculus (P62746), Mus musculus
Manually annotated by BRENDA team
Moon, M.Y.; Kim, H.J.; Kim, J.G.; Lee, J.Y.; Kim, J.; Kim, S.C.; Choi, I.G.; Kim, P.H.; Park, J.B.
Small GTPase Rap1 regulates cell migration through regulation of small GTPase RhoA activity in response to transforming growth factor-beta1
J. Cell. Physiol.
228
2119-2126
2013
Mus musculus (Q91VL8), Mus musculus (Q9QUI0), Mus musculus C57BL/6 (Q91VL8), Mus musculus C57BL/6 (Q9QUI0)
Manually annotated by BRENDA team
Kumar, S.; Xu, J.; Kumar, R.S.; Lakshmikanthan, S.; Kapur, R.; Kofron, M.; Chrzanowska-Wodnicka, M.; Filippi, M.D.
The small GTPase Rap1b negatively regulates neutrophil chemotaxis and transcellular diapedesis by inhibiting Akt activation
J. Exp. Med.
211
1741-1758
2014
Mus musculus (Q99JI6), Mus musculus C57BL/6 (Q99JI6)
Manually annotated by BRENDA team
Gerasimcik, N.; Dahlberg, C.I.; Baptista, M.A.; Massaad, M.J.; Geha, R.S.; Westerberg, L.S.; Severinson, E.
The Rho GTPase Cdc42 is essential for the activation and function of mature B cells
J. Immunol.
194
4750-4758
2015
Mus musculus, Mus musculus C57BL/6
Manually annotated by BRENDA team
Rousset, M.; Cens, T.; Menard, C.; Bowerman, M.; Bellis, M.; Bruses, J.; Raoul, C.; Scamps, F.; Charnet, P.
Regulation of neuronal high-voltage activated CaV2 Ca2+ channels by the small GTPase RhoA
Neuropharmacology
97
201-209
2015
Mus musculus (Q9QUI0)
Manually annotated by BRENDA team
Miura, Y.; Kanaho, Y.
ACAP3, the GTPase-activating protein specific to the small GTPase Arf6, regulates neuronal migration in the developing cerebral cortex
Biochem. Biophys. Res. Commun.
493
1089-1094
2017
Mus musculus (P62331), Mus musculus C57BL/6J (P62331)
Manually annotated by BRENDA team
Yoo, J.; Brady, S.; Acosta-Alvarez, L.; Rogers, A.; Peng, J.; Sorensen, L.; Wolff, R.; Mleynek, T.; Shin, D.; Rich, C.; Kircher, D.; Bild, A.; Odelberg, S.; Li, D.; Holmen, S.; Grossmann, A.
The small GTPase ARf6 activates PI3K in melanoma to induce a prometastatic state
Cancer Res.
79
2892-2908
2019
Homo sapiens (P62330), Homo sapiens, Mus musculus (P62331)
Manually annotated by BRENDA team
Carvalho, B.C.; Oliveira, L.C.; Rocha, C.D.; Fernandes, H.B.; Oliveira, I.M.; Leao, F.B.; Valverde, T.M.; Rego, I.M.G.; Ghosh, S.; Silva, A.M.
Both knock-down and overexpression of Rap2a small GTPase in macrophages result in impairment of NF-kappaB activity and inflammatory gene expression
Mol. Immunol.
109
27-37
2019
Mus musculus (Q80ZJ1)
Manually annotated by BRENDA team