Reference on EC 3.6.5.1 - heterotrimeric G-protein GTPase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Natochin, M.; Granovsky, A.E.; Artemyev, N.O.
Regulation of transducin GTPase activity by human retinal RGS
J. Biol. Chem.
272
17444-17449
1997
Homo sapiens
Ueda, H.; Misawa, H.; Katada, T.; Ui, M.; Takagi, H.; Satoh, M.
Functional reconstitution of purified Gi and Go with mue-opioid receptors in guinea pig striatal membranes pretreated with micromolar concentrations of N-ethylmaleimide
J. Neurochem.
54
841-848
1990
Bos taurus, Homo sapiens, Sus scrofa
Kikkawa, S.; Takahashi, K.; Takahashi, K.; Shimada, N.; Ui, M.; Kimura, N.; Katada, T.
Conversion of GDP into GTP by nucleosifde diphosphate kinase on the GTP-binding proteins
J. Biol. Chem.
265
21536-21540
1990
Bos taurus
Shinozawa, T.; Uchida, S.; Martin, E.; Cafiso, D.; Hubbell, W.; Bitensky, M.
Additional component required for activity and reconstitution of light-activated vertebrate photoreceptor GTPase
Proc. Natl. Acad. Sci. USA
77
1408-1411
1980
vertebrata
Ueda, N.; Iniguez-Lluhi, J.A.; Lee, E.; Smrcka, A.V.; Robishaw, J.D.; Gilman, A.G.
G protein betagamma subunits. Simplified purification and properties of novel isoforms
J. Biol. Chem.
269
4388-4395
1994
Bos taurus, Oryctolagus cuniculus
Bondarenko, V.A.; Desai, M.; Dua, S.; Yamazaki, M.; Amin, R.H.; Yousif, K.K.; Kinumi, T.; Ohashi, M.; Komori, N.; Matsumoto, H.; Jackson, K.W.; Hayashi, F.; Usukura, J.; Lipkin, V.M.; Yamazaki, A.
Residues within the polycationic region of cGMP phosphodiesterase gamma subunit crucial for the interaction with transducin alpha subunit. Identification by endogenous ADP-ribosylation and site-directed mutagenesis
J. Biol. Chem.
272
15856-15864
1997
Lithobates catesbeianus, Lithobates grylio
Ming, D.; Ruiz-Avila, L.; Margolskee, R.F.
Characterization and solubilization of bitter-responsive receptors that couple to gustducin
Proc. Natl. Acad. Sci. USA
95
8933-8938
1998
Bos taurus
Arshavsky, V.Y.; Dumke, C.L.; Zhu, Y.; Artemyev, N.O.; Skiba, N.P.; Hamm, H.E.; Bownds, M.D.
Regulation of transducin GTPase activity in bovine rod outer segments
J. Biol. Chem.
269
19882-19887
1994
Bos taurus
Rouot, B.; Brabet, P.; Homburger, V.; Toutant, M.; Bockaert, J.
Go, a major brain GTP binding protein in search of a function: purification, immunological and biochemical characteristics
Biochimie
69
339-349
1987
Bos taurus, Canis lupus familiaris, Gallus gallus, Homo sapiens, Rattus norvegicus
Wise, A.; Watson-Koken, M.A.; Rees, S.; Lee, M.; Milligan, G.
Interactions of the alpha2A-adrenoceptor with multiple Gi-family G-proteins: studies with pertussis toxin-resistant G-protein mutants
Biochem. J.
321
721-728
1997
Rattus norvegicus
Nakamura, F.; Kato, M.; Kameyama, K.; Nukada, T.; Haga, T.; Kato, H.; Takenawa, T.; Kikkawa, U.
Characterization of Gq family G proteins GL1alpha(G14alpha), GL2alpha(G11alpha), and Gqalpga expressed in the baculovirus-insect cell system
J. Biol. Chem.
270
6246-6253
1995
Bos taurus
Sprang, S.R.
G Protein mechanism: insights from structural analysis
Annu. Rev. Biochem.
66
639-678
1997
Mammalia
Berstein, G.; Blank, J.L.; Jhon, D.Y.; Exton, J.H.; Rhee, S.G.; Ross, E.M.
Phospholipase C-beta1 is a GTPase-activating protein for Gq/11, its physiologic regulator
Cell
70
411-418
1992
Bos taurus
Ross, B.M.; McLaughlin, M.; Roberts, M.; Milligan, G.; McCulloch, J.; Knowler, J.T.
Alterations in the activity of adenylate cyclase and high affinity GTPase in Alzheimer's disease
Brain Res.
622
35-42
1993
Homo sapiens
Soomets, U.; Mahlapuu, R.; Tehranian, R.; Jarvet, J.; Karelson, E.; Zilmer, M.; Iverfeldt, K.; Zorko, M.; Graeslund, A.; Langel, U.
Regulation of GTPase and adenylate cyclase activity by amyloid beta-peptide and its fragments in rat brain tissue
Brain Res.
850
179-188
1999
Rattus norvegicus
Antonny, B.; Otto-Bruc, A.; Chabre, M.; Vuong, T.M.
GTP hydrolysis by purified alpha-subunit of transducin and its complex with the cyclic GMP phosphodiesterase inhibitor
Biochemistry
32
8646-8653
1993
Bos taurus
Sauvage, C.; Rumigny, J.F.; Maitre, M.
Purification and characterization of G proteins from human brain: modification of GTPase activity upon phosphorylation
Mol. Cell. Biochem.
107
65-77
1991
Homo sapiens
Tsai, S.C.; Adamik, R.; Kanaho, Y.; Halpern, J.L.; Moss, J.
Immunological and biochemical differentiation of guanyl nucleotide binding proteins: interaction of Goalpha with rhodopsin, anti-Goalpha polyclonal antibodies, and a monoclonal antibody against transducin alpha subunit and Gialpha
Biochemistry
26
4728-4733
1987
Bos taurus
Tesmer, J.J.G.; Berman, D.M.; Gilman, A.G.; Sprang, S.R.
Structure of RGS4 bound to AlF4-activated Gialpha1: stabilization of the transition state for GTP hydrolysis
Cell
89
251-261
1997
Rattus norvegicus, Rattus norvegicus Gialpha1
Neer, E.J.
Heterotrimeric G proteins: organizers of transmembrane signals
Cell
80
249-257
1995
Homo sapiens, Mammalia
Abood, M.E.; Hurley, J.B.; Pappone, M.C.; Bourne, H.R.; Stryer, L.
Functional homology between signal-coupling proteins
J. Biol. Chem.
257
10540-10543
1982
Bos taurus
Hallbrink, M.; Holmqvist, T.; Olsson, M.; Ostenson, C.G.; Efendic, S.; Langel, U.
Different domains in the third intracellular loop of the GLP-1 receptor are responsible for Galpha(s) and Galpha(i)/Galpha(o) activation
Biochim. Biophys. Acta
1546
79-86
2001
Rattus norvegicus
Seo, H.S.; Jeong, J.Y.; Nahm, M.Y.; Kim, S.W.; Lee, S.Y.; Bahk, J.D.
The effect of pH and various cations on the GTP hydrolysis of rice heterotrimeric G-protein alpha subunit expressed in Escherichia coli
J. Biochem. Mol. Biol.
36
196-200
2003
Oryza sativa
Park, I.K.; Klug, C.A.; Li, K.; Jerabek, L.; Li, L.; Nanamori, M.; Neubig, R.R.; Hood, L.; Weissman, I.L.; Clarke, M.F.
Molecular cloning and characterization of a novel regulator of G-protein signaling from mouse hematopoietic stem cells
J. Biol. Chem.
276
915-923
2001
Homo sapiens
Hooks, S.B.; Waldo, G.L.; Corbitt, J.; Bodor, E.T.; Krumins, A.M.; Harden, T.K.
RGS6, RGS7, RGS9, and RGS11 stimulate GTPase activity of Gi family G-proteins with differential selectivity and maximal activity
J. Biol. Chem.
278
10087-10093
2003
Spodoptera frugiperda
Zhao, J.; Wang, X.
Arabidopsis phospholipase Dalpha1 interacts with the heterotrimeric G-protein alpha-subunit through a motif analogous to the DRY motif in G-protein-coupled receptors
J. Biol. Chem.
279
1794-1800
2004
Arabidopsis thaliana
Brito, M.; Guzman, L.; Romo, X.; Soto, X.; Hinrichs, M.V.; Olate, J.
S111N mutation in the helical domain of human Gs(alpha) reduces its GDP/GTP exchange rate
J. Cell. Biochem.
85
615-620
2002
Homo sapiens
Masuho, I.; Itoh, M.; Itoh, H.; Saitoh, O.
The mechanism of membrane-translocation of regulator of G-protein signaling (RGS) 8 induced by Galpha expression
J. Neurochem.
88
161-168
2004
Rattus norvegicus
Traver, S.; Splingard, A.; Gaudriault, G.; De Gunzburg, J.
The RGS (regulator of G-protein signalling) and GoLoco domains of RGS14 co-operate to regulate Gi-mediated signalling
Biochem. J.
379
627-632
2004
Mammalia
Baker, S.A.; Martemyanov, K.A.; Shavkunov, A.S.; Arshavsky, V.Y.
Kinetic mechanism of RGS9-1 potentiation by R9AP
Biochemistry
45
10690-10697
2006
Bos taurus
Siderovski, D.P.; Willard, F.S.
The GAPs, GEFs, and GDIs of heterotrimeric G-protein alpha subunits
Int. J. Biol. Sci.
1
51-66
2005
Aspergillus nidulans, Saccharomyces cerevisiae, Caenorhabditis elegans, Homo sapiens
Nair, K.S.; Mendez, A.; Blumer, J.B.; Rosenzweig, D.H.; Slepak, V.Z.
The presence of a Leu-Gly-Asn repeat-enriched protein (LGN), a putative binding partner of transducin, in ROD photoreceptors
Invest. Ophthalmol. Vis. Sci.
46
383-389
2005
Bos taurus, Mus musculus
Kerov, V.; Chen, D.; Moussaif, M.; Chen, Y.J.; Chen, C.K.; Artemyev, N.O.
Transducin activation state controls its light-dependent translocation in rod photoreceptors
J. Biol. Chem.
280
41069-41076
2005
Mus musculus
Kerov, V.S.; Natochin, M.; Artemyev, N.O.
Interaction of transducin-alpha with LGN, a G-protein modulator expressed in photoreceptor cells
Mol. Cell. Neurosci.
28
485-495
2005
Mus musculus
Clark, M.A.; Lambert, N.A.
Endogenous regulator of G-protein signaling proteins regulate the kinetics of Galphaq/11-mediated modulation of ion channels in central nervous system neurons
Mol. Pharmacol.
69
1280-1287
2006
Rattus norvegicus
Barren, B.; Natochin, M.; Artemyev, N.O.
Mutation R238E in transducin-alpha yields a GTPase and effector-deficient, but not dominant-negative, G-protein alpha-subunit
Mol. Vis.
12
492-498
2006
Homo sapiens
Pina, A.L.; Baumert, U.; Loyer, M.; Koenekoop, R.K.
A three base pair deletion encoding the amino acid (lysine-270) in the alpha-cone transducin gene
Mol. Vis.
10
265-271
2004
Homo sapiens
Thomas, C.J.; Du, X.; Li, P.; Wang, Y.; Ross, E.M.; Sprang, S.R.
Uncoupling conformational change from GTP hydrolysis in a heterotrimeric G protein alpha-subunit
Proc. Natl. Acad. Sci. USA
101
7560-7565
2004
Mammalia
Digby, G.J.; Lober, R.M.; Sethi, P.R.; Lambert, N.A.
Some G protein heterotrimers physically dissociate in living cells
Proc. Natl. Acad. Sci. USA
21
17789-17794
2006
Homo sapiens
De Vendittis, E.; Adinolfi, B.S.; Amatruda, M.R.; Raimo, G.; Masullo, M.; Bocchini, V.
The A26G replacement in the consensus sequence A-X-X-X-X-G-K-[T,S] of the guanine nucleotide binding site activates the intrinsic GTPase of the elongation factor 2 from the archaeon Sulfolobus solfataricus
Eur. J. Biochem.
262
600-605
1999
Saccharolobus solfataricus
Raimo, G.; Masullo, M.; Bocchini, V.
Studies on the polypeptide elongation factor 2 from Sulfolobus solfataricus. Interaction with guanosine nucleotides and GTPase activity stimulated by ribosomes
J. Biol. Chem.
270
21082-21085
1995
Saccharolobus solfataricus
Layden, B.T.; Saengsawang, W.; Donati, R.J.; Yang, S.; Mulhearn, D.C.; Johnson, M.E.; Rasenick, M.M.
Structural model of a complex between the heterotrimeric G protein, Gsalpha, and tubulin
Biochim. Biophys. Acta
1783
964-973
2008
Bos taurus (P04896)
Wu, G.
Regulation of the trafficking and function of G protein-coupled receptors by Rab1 GTPase in cardiomyocytes
Methods Enzymol.
438
227-238
2008
Mus musculus
Shen, Y.; Han, Y.J.; Kim, J.I.; Song, P.S.
Arabidopsis nucleoside diphosphate kinase-2 as a plant GTPase activating protein
BMB Rep.
41
645-650
2008
Arabidopsis thaliana
Smith, B.; Hill, C.; Godfrey, E.L.; Rand, D.; van den Berg, H.; Thornton, S.; Hodgkin, M.; Davey, J.; Ladds, G.
Dual positive and negative regulation of GPCR signaling by GTP hydrolysis
Cell. Signal.
21
1151-1160
2009
Saccharomyces pombe
Preuss, I.; Kurig, B.; Nuernberg, B.; Orth, J.H.; Aktories, K.
Pasteurella multocida toxin activates Gbetagamma dimers of heterotrimeric G proteins
Cell. Signal.
21
551-558
2009
Homo sapiens, Mus musculus
Dave, R.H.; Saengsawang, W.; Yu, J.Z.; Donati, R.; Rasenick, M.M.
Heterotrimeric G-proteins interact directly with cytoskeletal components to modify microtubule-dependent cellular processes
Neurosignals
17
100-108
2009
Homo sapiens, Mus musculus, Rattus norvegicus
Orth, J.H.; Preuss, I.; Fester, I.; Schlosser, A.; Wilson, B.A.; Aktories, K.
Pasteurella multocida toxin activation of heterotrimeric G proteins by deamidation
Proc. Natl. Acad. Sci. USA
106
7179-7184
2009
Homo sapiens, Mus musculus
Kamitani, S.; Ao, S.; Toshima, H.; Tachibana, T.; Hashimoto, M.; Kitadokoro, K.; Fukui-Miyazaki, A.; Abe, H.; Horiguchi, Y.
Enzymatic actions of Pasteurella multocida toxin detected by monoclonal antibodies recognizing the deamidated alpha subunit of the heterotrimeric GTPase Gq
FEBS J.
278
2702-2712
2011
Pasteurella multocida
Anantharaman, V.; Abhiman, S.; de Souza, R.F.; Aravind, L.
Comparative genomics uncovers novel structural and functional features of the heterotrimeric GTPase signaling system
Gene
475
63-78
2011
Trichomonas vaginalis
Kozasa, T.; Hajicek, N.; Chow, C.R.; Suzuki, N.
Signalling mechanisms of RhoGTPase regulation by the heterotrimeric G proteins G12 and G13
J. Biochem.
150
357-369
2011
Caenorhabditis elegans, Drosophila melanogaster, Homo sapiens
Choudhury, S.R.; Westfall, C.S.; Laborde, J.P.; Bisht, N.C.; Jez, J.M.; Pandey, S.
Two chimeric regulators of G-protein signaling (RGS) proteins differentially modulate soybean heterotrimeric G-protein cycle
J. Biol. Chem.
287
17870-17881
2012
Glycine max
Bisht, N.C.; Jez, J.M.; Pandey, S.
An elaborate heterotrimeric G-protein family from soybean expands the diversity of plant G-protein networks
New Phytol.
190
35-48
2011
Glycine max
Tishchenko, S.; Gabdulkhakov, A.; Tin, U.; Kostareva, O.; Lin, C.; Katanaev, V.L.
Crystallization and preliminary X-ray diffraction studies of Drosophila melanogaster Galphao-subunit of heterotrimeric G protein in complex with the RGS domain of CG5036
Acta Crystallogr. Sect. F
69
61-64
2013
Drosophila melanogaster
Won, S.; Michkov, A.V.; Krystofova, S.; Garud, A.V.; Borkovich, K.A.
Genetic and physical interactions between Galpha subunits and components of the Gbetagamma dimer of heterotrimeric G proteins in Neurospora crassa
Eukaryot. Cell
11
1239-1248
2012
Neurospora crassa (Q05425 and Q05424 and Q9HFW7), Neurospora crassa 74 A-OR23-1A (Q05425 and Q05424 and Q9HFW7)
Koester, M.; DellOrco, D.; Koch, K.W.
The interaction network of rhodopsin involving the heterotrimeric G-protein transducin and the monomeric GTPase Rac1 is determined by distinct binding processes
FEBS J.
281
5175-5185
2014
Bos taurus
Zhao, P.; Nunn, C.; Ramineni, S.; Hepler, J.R.; Chidiac, P.
The Ras-binding domain region of RGS14 regulates its functional interactions with heterotrimeric G proteins
J. Cell. Biochem.
114
1414-1423
2013
Homo sapiens
Romero-Castillo, R.A.; Roy Choudhury, S.; Leon-Felix, J.; Pandey, S.
Characterization of the heterotrimeric G-protein family and its transmembrane regulator from capsicum (Capsicum annuum L.)
Plant Sci.
234
97-109
2015
Capsicum annuum
Choudhury, S.R.; Westfall, C.S.; Pandey, S.
The RGS proteins add to the diversity of soybean heterotrimeric G-protein signaling
Plant Signal. Behav.
7
1114-1117
2012
Glycine max
Li, Y.; Tang, X.; Yang, L.; Yu, Y.; Li, X.
Possible involvement of heterotrimeric G-protein signaling in Al-induced secretion of organic acid anions in Arabidopsis and rye
Plant Soil
388
55-63
2015
Arabidopsis thaliana, Secale cereale, Arabidopsis thaliana Col-0
-
Avasarala, S.; Bikkavilli, R.K.; Van Scoyk, M.; Zhang, W.; Lapite, A.; Hostetter, L.; Byers, J.T.; Heasley, L.E.; Sohn, J.W.; Winn, R.A.
Heterotrimeric G-protein, Galpha16, is a critical downstream effector of non-canonical Wnt signaling and a potent inhibitor of transformed cell growth in non small cell lung cancer
PLoS ONE
8
e76895
2013
Homo sapiens (P30679)
Leal, J.I.; Villaseca, S.; Beyer, A.; Toro-Tapia, G.; Torrejon, M.
Ric-8A, a GEF for heterotrimeric G-proteins, controls cranial neural crest cell polarity during migration
Mech. Dev.
154
170-178
2018
Xenopus tropicalis
Choudhury, S.R.; Pandey, S.
Phosphorylation-dependent regulation of G-protein cycle during nodule formation in soybean
Plant Cell
27
3260-3276
2015
Glycine max
Pandey, S.
Heterotrimeric G-protein regulatory circuits in plants conserved and novel mechanisms
Plant Signal. Behav.
12
e1325983
2017
Arabidopsis thaliana
Kaiser, A.; Langer, B.; Przyborski, J.; Kersting, D.; Krueger, M.
A putative non-canonical Ras-like GTPase from P. falciparum chemical properties and characterization of the protein
PLoS ONE
10
e0140994
2015
no activity in Plasmodium falciparum
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