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Information on EC 3.6.4.B9 - Rad54 translocase and Organism(s) Homo sapiens and UniProt Accession Q92698

for references in articles please use BRENDA:EC3.6.4.B9
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Homo sapiens
UNIPROT: Q92698
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The taxonomic range for the selected organisms is: Homo sapiens
The expected taxonomic range for this enzyme is: Eukaryota, Archaea
Reaction Schemes
Synonyms
rad54b, rad54l, rad54 protein, dsdna translocase, rad54 translocase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
DNA repair and recombination protein RAD54-like
UniProt
DNA repair and recombination protein RAD54B
UniProt
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + H2O
ADP + phosphate
show the reaction diagram
-
-
-
?
ATP + H2O
ADP + phosphate
show the reaction diagram
-
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + H2O
ADP + phosphate
show the reaction diagram
-
-
-
?
ATP + H2O
ADP + phosphate
show the reaction diagram
-
-
-
?
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
UniProt
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
combined depletion of RAD54L and RAD54B and/or artificial induction of RAD51 overexpression blocks replication and promotes chromosome segregation defects. RAD54 translocase depletion increases RAD51 focus formation in MCF7 cells
physiological function
the mammalian translocases, RAD54L and RAD54B, function to prevent the accumulation of nondamage-associated RAD51 complexes. RAD54L and RAD54B counteract genome-destabilizing effects of direct binding of RAD51 to dsDNA in human tumor cells. RAD54 been shown to remove RAD51 from dsDNA, it has also been reported to stabilize the interaction of RAD51 with ssDNA in vitro by a process that does not require ATP hydrolysis. RAD54 family translocases prevent accumulation of nondamage-associated RAD51 complexes in MCF-7 cells
malfunction
combined depletion of RAD54L and RAD54B and/or artificial induction of RAD51 overexpression blocks replication and promotes chromosome segregation defects. RAD54 translocase depletion increases RAD51 focus formation in MCF7 cells
physiological function
the mammalian translocases, RAD54L and RAD54B, function to prevent the accumulation of nondamage-associated RAD51 complexes. RAD54L and RAD54B counteract genome-destabilizing effects of direct binding of RAD51 to dsDNA in human tumor cells. RAD54 removes RAD51 from dsDNA, it has also been reported to stabilize the interaction of RAD51 with ssDNA in vitro by a process that does not require ATP hydrolysis. RAD54 family translocases prevent accumulation of nondamage-associated RAD51 complexes in MCF-7 cells
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
RAD54_HUMAN
747
0
84352
Swiss-Prot
Secretory Pathway (Reliability: 1)
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Mason, J.M.; Dusad, K.; Wright, W.D.; Grubb, J.; Budke, B.; Heyer, W.D.; Connell, P.P.; Weichselbaum, R.R.; Bishop, D.K.
RAD54 family translocases counter genotoxic effects of RAD51 in human tumor cells
Nucleic Acids Res.
43
3180-3196
2015
Homo sapiens (Q92698), Homo sapiens (Q9Y620), Homo sapiens
Manually annotated by BRENDA team