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Adenocarcinoma
Human and mouse homologs of the Schizosaccharomyces pombe rad17+ cell cycle checkpoint control gene.
Ataxia
Ataxia telangiectasia-mutated kinase deficiency exacerbates left ventricular dysfunction and remodeling late after myocardial infarction.
Ataxia
Biallelic expansion of an intronic repeat in RFC1 is a common cause of late-onset ataxia.
Ataxia
Clinical spectrum of the pentanucleotide repeat expansion in the RFC1 gene in ataxia syndromes.
Ataxia
Prevalence of RFC1-mediated spinocerebellar ataxia in a North American ataxia cohort.
Ataxia
Update on Cerebellar Ataxia with Neuropathy and Bilateral Vestibular Areflexia Syndrome (CANVAS).
Ataxia Telangiectasia
Ataxia telangiectasia mutated (ATM) inhibition transforms human mammary gland epithelial cells.
Ataxia Telangiectasia
Ataxia-telangiectasia and Rad3-related and DNA-dependent protein kinase cooperate in G2 checkpoint activation by the DNA strand-breaking nucleoside analogue 2'-C-cyano-2'-deoxy-1-beta-D-arabino-pentofuranosylcytosine.
Ataxia Telangiectasia
Chromatin association of rad17 is required for an ataxia telangiectasia and rad-related kinase-mediated S-phase checkpoint in response to low-dose ultraviolet radiation.
Ataxia Telangiectasia
Deficiency of ataxia telangiectasia mutated kinase modulates cardiac remodeling following myocardial infarction: involvement in fibrosis and apoptosis.
Bilateral Vestibulopathy
Biallelic expansion of an intronic repeat in RFC1 is a common cause of late-onset ataxia.
Bilateral Vestibulopathy
Biallelic RFC1 pentanucleotide repeat expansions in Greek patients with late-onset ataxia.
Bilateral Vestibulopathy
CANVAS: A New Genetic Entity in the Otorhinolaryngologist's Differential Diagnosis.
Bilateral Vestibulopathy
Clinical spectrum of the pentanucleotide repeat expansion in the RFC1 gene in ataxia syndromes.
Bilateral Vestibulopathy
RFC1 AAGGG repeat expansion masquerading as Chronic Idiopathic Axonal Polyneuropathy.
Bilateral Vestibulopathy
RFC1 repeat expansion in Japanese patients with late-onset cerebellar ataxia.
Bloom Syndrome
A novel role for Rad17 in homologous recombination.
Breast Neoplasms
A superfamily of conserved domains in DNA damage-responsive cell cycle checkpoint proteins.
Breast Neoplasms
Ataxia telangiectasia mutated (ATM) inhibition transforms human mammary gland epithelial cells.
Breast Neoplasms
Human immunodeficiency virus type 1 Vpr-mediated G2 arrest requires Rad17 and Hus1 and induces nuclear BRCA1 and gamma-H2AX focus formation.
Breast Neoplasms
Regulation of Rad17 protein turnover unveils an impact of Rad17-APC cascade in breast carcinogenesis and treatment.
Breast Neoplasms
Substitution of aspartic acid with glutamic acid at position 67 of the BRCA1 RING domain retains ubiquitin ligase activity and zinc(II) binding with a reduced transition temperature.
Breast Neoplasms
The RING heterodimer BRCA1-BARD1 is a ubiquitin ligase inactivated by the platinum-based anticancer drugs.
Carcinogenesis
Expression profile and prognostic value of SFN in human ovarian cancer.
Carcinogenesis
LPS promotes HBO1 stability via USP25 to modulate inflammatory gene transcription in THP-1 cells.
Carcinogenesis
Regulation of Rad17 protein turnover unveils an impact of Rad17-APC cascade in breast carcinogenesis and treatment.
Carcinoma
Genetic polymorphism at codon 546 of the human RAD17 contributes to the risk for esophageal squamous cell carcinoma.
Carcinoma
HRad17, a human homologue of the Schizosaccharomyces pombe checkpoint gene rad17, is overexpressed in colon carcinoma.
Carcinoma
Human and mouse homologs of the Schizosaccharomyces pombe rad17+ cell cycle checkpoint control gene.
Carcinoma
The miR-205-5p/BRCA1/RAD17 Axis Promotes Genomic Instability in Head and Neck Squamous Cell Carcinomas.
Carcinoma, Hepatocellular
Exploration of Prognostic Biomarkers among Replication Factor C Family in the Hepatocellular Carcinoma.
Carcinoma, Hepatocellular
Novel candidate biomarkers of origin recognition complex 1, 5 and 6 for survival surveillance in patients with hepatocellular carcinoma.
Carcinoma, Hepatocellular
Nuclear recruitment of A1p145 subunit of replication factor C in the early G1 phase of the cell cycle in Faza 567 hepatoma cell line and hepatocyte primary cultures.
Carcinoma, Non-Small-Cell Lung
Human and mouse homologs of the Schizosaccharomyces pombe rad17+ cell cycle checkpoint control gene.
Carcinoma, Non-Small-Cell Lung
Human Rad17 is phosphorylated upon DNA damage and also overexpressed in primary non-small cell lung cancer tissues.
Carcinoma, Squamous Cell
Human and mouse homologs of the Schizosaccharomyces pombe rad17+ cell cycle checkpoint control gene.
Carcinoma, Squamous Cell
The miR-205-5p/BRCA1/RAD17 Axis Promotes Genomic Instability in Head and Neck Squamous Cell Carcinomas.
Cerebellar Ataxia
Biallelic RFC1 pentanucleotide repeat expansions in Greek patients with late-onset ataxia.
Cerebellar Ataxia
CANVAS: A New Genetic Entity in the Otorhinolaryngologist's Differential Diagnosis.
Cerebellar Ataxia
Clinical spectrum of the pentanucleotide repeat expansion in the RFC1 gene in ataxia syndromes.
Cerebellar Ataxia
RFC1 AAGGG repeat expansion masquerading as Chronic Idiopathic Axonal Polyneuropathy.
Cerebellar Ataxia
RFC1 repeat expansion in Japanese patients with late-onset cerebellar ataxia.
Choriocarcinoma
[Expression of RFC2 and PCNA in different gestational trophoblastic diseases]
Colonic Neoplasms
DNA Replication and Sister Chromatid Cohesion 1 (DSCC1) of the Replication Factor Complex CTF18-RFC is Critical for Colon Cancer Cell Growth.
Colonic Neoplasms
Hrad17 expression in thymoma.
Colonic Neoplasms
Overexpression of Hrad17 gene in non-small cell lung cancers correlated with lymph node metastasis.
Colonic Neoplasms
Overexpression of Krüppel-like factor 4 in the human colon cancer cell line RKO leads to reduced tumorigenecity.
Colorectal Neoplasms
Levels of human replication factor C4, a clamp loader, correlate with tumor progression and predict the prognosis for colorectal cancer.
Colorectal Neoplasms
Mutational and expressional analysis of RFC3, a clamp loader in DNA replication, in gastric and colorectal cancers.
Dwarfism
Mutations in ORC1, encoding the largest subunit of the origin recognition complex, cause microcephalic primordial dwarfism resembling Meier-Gorlin syndrome.
Esophageal Squamous Cell Carcinoma
Genetic polymorphism at codon 546 of the human RAD17 contributes to the risk for esophageal squamous cell carcinoma.
Fanconi Anemia
Cdc5L interacts with ATR and is required for the S-phase cell-cycle checkpoint.
Genetic Diseases, Inborn
Update on Cerebellar Ataxia with Neuropathy and Bilateral Vestibular Areflexia Syndrome (CANVAS).
Gestational Trophoblastic Disease
The second subunit of the replication factor C complex (RFC40) and the regulatory subunit (RIalpha) of protein kinase A form a protein complex promoting cell survival.
Glioblastoma
MicroRNA-744-5p inhibits glioblastoma malignancy by suppressing replication factor C subunit 2.
Glioma
Enhanced radiation-induced cytotoxic effect by 2-ME in glioma cells is mediated by induction of cell cycle arrest and DNA damage via activation of ATM pathways.
Glioma
Forkhead box O1 targeting replication factor C subunit 2 expression promotes glioma temozolomide resistance and survival.
Glioma
Origin recognition complex subunit 1 regulates cell growth and metastasis in glioma by altering activation of ERK and JNK signaling pathway.
Glioma
Targeting multiple pathways in gliomas with stem cell and viral delivered S-TRAIL and Temozolomide.
Head and Neck Neoplasms
Downregulation of RAD17 in head and neck cancer.
Hydatidiform Mole
[Expression of RFC2 and PCNA in different gestational trophoblastic diseases]
Hypersensitivity
hRAD17, a structural homolog of the Schizosaccharomyces pombe RAD17 cell cycle checkpoint gene, stimulates p53 accumulation.
Infections
Efficiency and frequency of translational coupling between the bacteriophage T4 clamp loader genes.
Infections
Pathogenic and apathogenic courses of SIV infection are associated with distinct and characteristic regulatory patterns of G1/S and G2/M cell cycle checkpoints in CD4+ T cells.
Leiomyoma
ORC5L, a new member of the human origin recognition complex, is deleted in uterine leiomyomas and malignant myeloid diseases.
Leukemia
The isolation of a DNA synthesome from human leukemia cells.
Leukemia, Myeloid
Mutation analysis of the origin recognition complex subunit 5 (ORC5L) gene in adult patients with myeloid leukemias exhibiting deletions of chromosome band 7q22.
Leukemia, Myeloid, Acute
Mutation analysis of the origin recognition complex subunit 5 (ORC5L) gene in adult patients with myeloid leukemias exhibiting deletions of chromosome band 7q22.
Lung Neoplasms
Human Rad17 is phosphorylated upon DNA damage and also overexpressed in primary non-small cell lung cancer tissues.
Lung Neoplasms
Identification of RFC5 as a novel potential prognostic biomarker in lung cancer through bioinformatics analysis.
Lung Neoplasms
IQGAP3 interacts with Rad17 to recruit the Mre11-Rad50-Nbs1 complex and contributes to radioresistance in lung cancer.
Lymphoma
ATR-Chk1 signaling pathway and homologous recombinational repair protect cells from 5-fluorouracil cytotoxicity.
Lymphoma
Deleting Ku70 is milder than deleting Ku80 in p53-mutant mice and cells.
Lymphoma
Rad9, Rad17, TopBP1 and claspin play essential roles in heat-induced activation of ATR kinase and heat tolerance.
Lymphoma, B-Cell
WEE1 Inhibition Enhances Anti-Apoptotic Dependency as a Result of Premature Mitotic Entry and DNA Damage.
Lymphoma, Large B-Cell, Diffuse
WEE1 Inhibition Enhances Anti-Apoptotic Dependency as a Result of Premature Mitotic Entry and DNA Damage.
Malaria
Expression and characterization of human malaria parasite Plasmodium falciparum origin recognition complex subunit 1.
Malaria
Functional dissection of the catalytic carboxyl-terminal domain of origin recognition complex subunit 1 (PfORC1) of the human malaria parasite Plasmodium falciparum.
Melanoma
Telomere damage induced by the G-quadruplex ligand RHPS4 has an antitumor effect.
Multiple Endocrine Neoplasia
Adrenergic Differentiation and Ret Expression in Rat Pheochromocytomas.
Myelodysplastic Syndromes
Mutation analysis of the origin recognition complex subunit 5 (ORC5L) gene in adult patients with myeloid leukemias exhibiting deletions of chromosome band 7q22.
Neoplasm Metastasis
DNA Replication and Sister Chromatid Cohesion 1 (DSCC1) of the Replication Factor Complex CTF18-RFC is Critical for Colon Cancer Cell Growth.
Neoplasm Metastasis
Origin recognition complex subunit 1 regulates cell growth and metastasis in glioma by altering activation of ERK and JNK signaling pathway.
Neoplasm Metastasis
RFC2, a direct target of miR-744, modulates the cell cycle and promotes the proliferation of CRC cells.
Neoplasm Metastasis
Up-regulated RFC2 predicts unfavorable progression in hepatocellular carcinoma.
Neoplasm Metastasis
Up-Regulation of RFC3 Promotes Triple Negative Breast Cancer Metastasis and is Associated With Poor Prognosis Via EMT.
Neoplasms
Adrenergic Differentiation and Ret Expression in Rat Pheochromocytomas.
Neoplasms
Atrazine Triggers DNA Damage Response and Induces DNA Double-Strand Breaks in MCF-10A Cells.
Neoplasms
Chemogenetic profiling identifies RAD17 as synthetically lethal with checkpoint kinase inhibition.
Neoplasms
Depletion of RAD17 sensitizes pancreatic cancer cells to gemcitabine.
Neoplasms
DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts.
Neoplasms
Downregulation of RAD17 in head and neck cancer.
Neoplasms
Functional identification of tumor-suppressor genes through an in vivo RNA interference screen in a mouse lymphoma model.
Neoplasms
Gain of function mutant p53 proteins cooperate with E2F4 to transcriptionally downregulate RAD17 and BRCA1 gene expression.
Neoplasms
Increased radiosensitivity with chronic hypoxia in four human tumor cell lines.
Neoplasms
Levels of human replication factor C4, a clamp loader, correlate with tumor progression and predict the prognosis for colorectal cancer.
Neoplasms
MicroRNA-744-5p inhibits glioblastoma malignancy by suppressing replication factor C subunit 2.
Neoplasms
Multifaceted regulation and functions of replication factor C family in human cancers.
Neoplasms
Mutation analysis of replicative genes encoding the large subunits of DNA polymerase alpha and replication factors A and C in human sporadic colorectal cancers.
Neoplasms
Mutation of the retinoblastoma tumor suppressor gene sensitizes cancers to mitotic inhibitor induced cell death.
Neoplasms
Nitric oxide, a mediator of inflammation, suppresses tumorigenesis.
Neoplasms
P53 and p21 (Waf1/Cip1) mRNA expression associated with DNA damage and repair in acute immune complex alveolitis in mice.
Neoplasms
Pan-cancer analysis of homozygous deletions in primary tumours uncovers rare tumour suppressors.
Neoplasms
Profiling of genes expressed in human monocytes and monocyte-derived dendritic cells using cDNA expression array.
Neoplasms
Reconstitution of complete SV40 DNA replication with purified replication factors.
Neoplasms
Regulation of RelA (p65) function by the large subunit of replication factor C.
Neoplasms
Replication stress and oxidative damage contribute to aberrant constitutive activation of DNA damage signalling in human gliomas.
Neoplasms
RFC2, a direct target of miR-744, modulates the cell cycle and promotes the proliferation of CRC cells.
Neoplasms
ShRNA-mediated silencing of the RFC3 gene suppress ovarian tumor cells proliferation.
Neoplasms
The human homolog of fission yeast Rad17 is implicated in tumor growth.
Neoplasms
The miR-205-5p/BRCA1/RAD17 Axis Promotes Genomic Instability in Head and Neck Squamous Cell Carcinomas.
Neoplasms
Up-regulated RFC2 predicts unfavorable progression in hepatocellular carcinoma.
Neoplasms
WEE1 Inhibition Enhances Anti-Apoptotic Dependency as a Result of Premature Mitotic Entry and DNA Damage.
Ovarian Neoplasms
Differential hRad17 expression by histologic subtype of ovarian cancer.
Pancreatic Neoplasms
Depletion of RAD17 sensitizes pancreatic cancer cells to gemcitabine.
Pheochromocytoma
Adrenergic Differentiation and Ret Expression in Rat Pheochromocytomas.
Progeria
Replication factor C1, the large subunit of replication factor C, is proteolytically truncated in Hutchinson-Gilford progeria syndrome.
Prostatic Neoplasms
BTF3 confers oncogenic activity in prostate cancer through transcriptional upregulation of Replication Factor C.
Prostatic Neoplasms
The Cell Cycle Checkpoint Gene, RAD17 rs1045051, Is Associated with Prostate Cancer Risk.
Pulmonary Disease, Chronic Obstructive
Age-dependent assessment of genes involved in cellular senescence, telomere and mitochondrial pathways in human lung tissue of smokers, COPD and IPF: Associations with SARS-CoV-2 COVID-19 ACE2-TMPRSS2-Furin-DPP4 axis.
Pulmonary Disease, Chronic Obstructive
Age-Dependent Assessment of Genes Involved in Cellular Senescence, Telomere, and Mitochondrial Pathways in Human Lung Tissue of Smokers, COPD, and IPF: Associations With SARS-CoV-2 COVID-19 ACE2-TMPRSS2-Furin-DPP4 Axis.
Retinoblastoma
Malignant transformation of thyroid follicular cells by galectin-3.
Retinoblastoma
Regulation of RelA (p65) function by the large subunit of replication factor C.
Seminoma
Human and mouse RAD17 genes: identification, localization, genomic structure and histological expression pattern in normal testis and seminoma.
Small Cell Lung Carcinoma
Human and mouse homologs of the Schizosaccharomyces pombe rad17+ cell cycle checkpoint control gene.
Squamous Cell Carcinoma of Head and Neck
Downregulation of RAD17 in head and neck cancer.
Squamous Cell Carcinoma of Head and Neck
Gain of function mutant p53 proteins cooperate with E2F4 to transcriptionally downregulate RAD17 and BRCA1 gene expression.
Squamous Cell Carcinoma of Head and Neck
Human and mouse homologs of the Schizosaccharomyces pombe rad17+ cell cycle checkpoint control gene.
Squamous Cell Carcinoma of Head and Neck
The miR-205-5p/BRCA1/RAD17 Axis Promotes Genomic Instability in Head and Neck Squamous Cell Carcinomas.
Stomach Neoplasms
High-Expression HBO1 Predicts Poor Prognosis in Gastric Cancer.
Williams Syndrome
The gene for replication factor C subunit 2 (RFC2) is within the 7q11.23 Williams syndrome deletion.
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3.6.4.B8 clamp-loader complex
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The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). 
