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Information on EC 3.6.4.B7 - RadA recombinase
for references in articles please use BRENDA:EC3.6.4.B7preliminary BRENDA-supplied EC number
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3.6.4.B7 RadA recombinaseSpecify your search results
Word Map
- 3.6.4.B7
- strand
- brca2
-
single-stranded
-
meiotic
- fork
-
checkpoint
- reca
- ssdna
- nucleoprotein
- helicase
-
stall
-
radiosensitivity
-
non-homologous
-
dna-damaging
-
fanconi
-
radiation-induced
-
chromatid
- mre11
- h2ax
-
interstrand
-
end-joining
-
recombinases
- chk1
-
meiosis-specific
-
homology-directed
- olaparib
- dna-pkcs
-
fancd2
-
restart
-
prophase
-
synaptonemal
-
parpis
-
error-free
-
reca-like
-
unrepaired
-
gamma-h2ax
-
dsb-induced
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d-loops
- ctip
-
break-induced
-
translesion
-
holliday
- bard1
- molecular biology
- synthesis
-
atr-dependent
-
topbp1
-
ssdna-binding
-
brca1-mutant
- rucaparib
- diagnostics
- analysis
- pharmacology
- xrcc4
-
brca1-deficient
The expected taxonomic range for this enzyme is: Archaea, Bacteria, Eukaryota
Synonyms
rad51, rada/sms, ssorada, rada recombinase, rada intein, dna repair protein rad51 homolog 1, radc1, dna repair and recombination protein, mvrada, hvo rada, 
more
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
additional information
?
-
The RecA/RadA-facilitated strand exchange reaction occurs in two steps: (a) the recombinases bind to ssDNA, forming a nucleoprotein complex, and (b) the nucleoprotein complex invades a homologous dsDNA, such that the invading RadA-ssDNA base pairs with the complimentary strand of the dsDNA whereas the other stranded of the DNA becomes ssDNA, forming a so-called D-loop structure. The D-loop structure is a very important intermediate in DNA repair or DNA replication processes. Formation of RadA-ssDNA filaments and stabilization, rotation mechanism of the enzyme nanobiomotor, overview
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-
?
ATP + H2O
ADP + phosphate
both ATP hydrolysis and DNA strand exchange requires accessibility to an active conformation similar to the crystallized ATPase-active form in the presence of ATP, Mg2+ and K+
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-
?
ATP + H2O
ADP + phosphate
single-stranded DNA-dependent ATPase
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-
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
additional information
?
-
The RecA/RadA-facilitated strand exchange reaction occurs in two steps: (a) the recombinases bind to ssDNA, forming a nucleoprotein complex, and (b) the nucleoprotein complex invades a homologous dsDNA, such that the invading RadA-ssDNA base pairs with the complimentary strand of the dsDNA whereas the other stranded of the DNA becomes ssDNA, forming a so-called D-loop structure. The D-loop structure is a very important intermediate in DNA repair or DNA replication processes. Formation of RadA-ssDNA filaments and stabilization, rotation mechanism of the enzyme nanobiomotor, overview
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-
?
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
K+
Mg2+ als well as K+ ions are absorbed at the ATPase center. K+ (but not Na+), stimulates the ATP hydrolysis reaction with an apparent dissociation constant of about 40 mM. The strand exchange activity of the wild-type enzyme is also stimulated by potassium with an apparent dissociation constant of 35 mM
Mg2+
Mg2+
required for ATPase activity. The enzyme contains a secondary Mg2+ site as well as a canonical P-loop and nucleotide-lined primary Mg2+ site. The secondary Mg2+ site is important for modulating the ATPase activity
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
NaCl
minimal inhibitory effect by 40 mM NaCl further suggests that the protein does not have adequate affinity for sodium
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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Acquired Immunodeficiency Syndrome
Monoclonal antibodies against the Escherichia coli DNA repair protein RadA/Sms.
Acquired Immunodeficiency Syndrome
Rad51 recombinase prevents Mre11 nuclease-dependent degradation and excessive PrimPol-mediated elongation of nascent DNA after UV irradiation.
Adenocarcinoma
Autoantibodies in sera of pancreatic cancer patients identify recombination factor Rad51 as a tumour-associated antigen.
Adenocarcinoma
DNA repair and recombination factor Rad51 is over-expressed in human pancreatic adenocarcinoma.
Adenocarcinoma
Expression of PH Domain Leucine-rich Repeat Protein Phosphatase, Forkhead Homeobox Type O 3a and RAD51, and their Relationships with Clinicopathologic Features and Prognosis in Ovarian Serous Adenocarcinoma.
Adenocarcinoma
High-level expression of Rad51 is an independent prognostic marker of survival in non-small-cell lung cancer patients.
Adenocarcinoma
Impact of RAD51C-mediated Homologous Recombination on Genomic Integrity in Barrett's Adenocarcinoma Cells.
Adenocarcinoma
Increased Expression of BRCA2 and RAD51 in Lymph Node Metastases of Canine Mammary Adenocarcinomas.
Adenocarcinoma
Ku70 and Rad51 vary in their importance for the repair of doxorubicin- versus etoposide-induced DNA damage.
Adenocarcinoma
Overexpression of Rad51 Predicts Poor Prognosis in Colorectal Cancer: Our Experience with 54 Patients.
Adenocarcinoma
RAD51 Inhibitor Reverses Etoposide-Induced Genomic Toxicity and Instability in Esophageal Adenocarcinoma Cells.
Adenocarcinoma
RAD51 overexpression is a negative prognostic marker for colorectal adenocarcinoma.
Adenocarcinoma
Targeting PI3K and RAD51 in Barrett's Adenocarcinoma: Impact on DNA Damage Checkpoints, Expression Profile and Tumor Growth.
Adenocarcinoma of Lung
(-)-Guaiol regulates RAD51 stability via autophagy to induce cell apoptosis in non-small cell lung cancer.
Adenocarcinoma of Lung
TP53 and DNA-repair gene polymorphisms genotyping as a low-cost lung adenocarcinoma screening tool.
Adenoma
Increased Expression of BRCA2 and RAD51 in Lymph Node Metastases of Canine Mammary Adenocarcinomas.
Adenoma
KLF4 Suppresses Tumor Formation in Genetic and Pharmacological Mouse Models of Colonic Tumorigenesis.
Adenoma
RAD51 as a candidate parathyroid tumour suppressor gene on chromosome 15q: absence of somatic mutations.
Adenomatous Polyposis Coli
Histological groups of human postpubertal testicular germ cell tumours harbour different genetic alterations.
Anemia
Effects of Sepantronium Bromide (YM-155) on the Whole Transcriptome of MDA-MB-231 Cells: Highlight on Impaired ATR/ATM Fanconi Anemia DNA Damage Response.
Astrocytoma
Expression analyses of 27 DNA repair genes in astrocytoma by TaqMan low-density array.
Ataxia Telangiectasia
A short G1 phase imposes constitutive replication stress and fork remodelling in mouse embryonic stem cells.
Ataxia Telangiectasia
Abnormal expression of p-ATM/CHK2 in nasal extranodal NK/T cell lymphoma, nasal type, is correlated with poor prognosis.
Ataxia Telangiectasia
c-Abl tyrosine kinase is not essential for ataxia telangiectasia mutated functions in chromosomal maintenance.
Ataxia Telangiectasia
Effects of Sepantronium Bromide (YM-155) on the Whole Transcriptome of MDA-MB-231 Cells: Highlight on Impaired ATR/ATM Fanconi Anemia DNA Damage Response.
Ataxia Telangiectasia
Glioblastoma cells block radiation-induced programmed cell death of endothelial cells.
Ataxia Telangiectasia
Inhibition of DNA repair protein RAD51 affects porcine preimplantation embryo development.
Ataxia Telangiectasia
Inhibition of PTEN activates bovine non-growing follicles in vitro but increases DNA damage and reduces DNA repair response.
Ataxia Telangiectasia
Low-Dose Irradiation Enhances Gene Targeting in Human Pluripotent Stem Cells.
Ataxia Telangiectasia
Maternal gene Ooep may participate in homologous recombination-mediated DNA double-strand break repair in mouse oocytes.
Ataxia Telangiectasia
Moving From Poly (ADP-Ribose) Polymerase Inhibition to Targeting DNA Repair and DNA Damage Response in Cancer Therapy.
Ataxia Telangiectasia
Oocytes can efficiently repair DNA double-strand breaks to restore genetic integrity and protect offspring health.
Ataxia Telangiectasia
RAD51C facilitates checkpoint signaling by promoting CHK2 phosphorylation.
Ataxia Telangiectasia
Regulation of DNA Damage Response by Estrogen Receptor ?-Mediated Inhibition of Breast Cancer Associated Gene 2.
Ataxia Telangiectasia
Targeting PI3K and RAD51 in Barrett's Adenocarcinoma: Impact on DNA Damage Checkpoints, Expression Profile and Tumor Growth.
Ataxia Telangiectasia
The Deacetylase Sirtuin 1 Regulates Human Papillomavirus Replication by Modulating Histone Acetylation and Recruitment of DNA Damage Factors NBS1 and Rad51 to Viral Genomes.
Bloom Syndrome
Bloom syndrome helicase stimulates RAD51 DNA strand exchange activity through a novel mechanism.
Bloom Syndrome
Functional interaction between the Bloom's syndrome helicase and the RAD51 paralog, RAD51L3 (RAD51D).
Bloom Syndrome
Structural and functional characterization of the N-terminal domain of human Rad51D.
Bloom Syndrome
The Bloom syndrome protein limits the lethality associated with RAD51 deficiency.
Bone Marrow Failure Disorders
Loss of the homologous recombination gene rad51 leads to Fanconi anemia-like symptoms in zebrafish.
Brain Neoplasms
Gleevec-mediated inhibition of Rad51 expression and enhancement of tumor cell radiosensitivity.
Brain Neoplasms
Immunohistochemical prediction of brain metastases in patients with advanced breast cancer: The role of Rad51.
Brain Neoplasms
RAD51-Mediated DNA Homologous Recombination Is Independent of PTEN Mutational Status.
Breast Neoplasms
A distinct replication fork protection pathway connects Fanconi anemia tumor suppressors to RAD51-BRCA1/2.
Breast Neoplasms
A DNA repair variant in POLQ (c.-1060A > G) is associated to hereditary breast cancer patients: a case-control study.
Breast Neoplasms
A homologous recombination defect affects replication-fork progression in mammalian cells.
Breast Neoplasms
A marker of homologous recombination predicts pathological complete response to neoadjuvant chemotherapy in primary breast cancer.
Breast Neoplasms
A novel small molecule RAD51 inactivator overcomes imatinib-resistance in chronic myeloid leukaemia.
Breast Neoplasms
A RAD51 assay feasible in routine tumor samples calls PARP inhibitor response beyond BRCA mutation.
Breast Neoplasms
A single nucleotide polymorphism in the 5' untranslated region of RAD51 and risk of cancer among BRCA1/2 mutation carriers.
Breast Neoplasms
A single nucleotide polymorphism in the RAD51 gene modifies cancer risk in BRCA2 but not BRCA1 carriers.
Breast Neoplasms
A single-nucleotide polymorphism in the RAD51 gene modifies breast cancer risk in BRCA2 carriers, but not in BRCA1 carriers or noncarriers.
Breast Neoplasms
A small molecule inhibitor of human RAD51 potentiates breast cancer cell killing by therapeutic agents in mouse xenografts.
Breast Neoplasms
A specific RAD51 haplotype increases breast cancer risk in Jewish non-Ashkenazi high-risk women.
Breast Neoplasms
A variant of the breast cancer type 2 susceptibility protein (BRC) repeat is essential for the RECQL5 helicase to interact with RAD51 recombinase for genome stabilization.
Breast Neoplasms
Aberrant Regulation of RAD51 Promotes Resistance of Neoadjuvant Endocrine Therapy in ER-positive Breast Cancer.
Breast Neoplasms
Acetylation of the cell-fate factor dachshund determines p53 binding and signaling modules in breast cancer.
Breast Neoplasms
Alternative transcript imbalance underlying breast cancer susceptibility in a family carrying PALB2 c.3201+5G>T.
Breast Neoplasms
Analysis of RAD51 polymorphism and BRCA1 mutations in Polish women with breast cancer.
Breast Neoplasms
Analysis of the G/C polymorphism in the 5'-untranslated region of the RAD51 gene in breast cancer.
Breast Neoplasms
ARLTS1, MDM2 and RAD51 gene variations are associated with familial breast cancer.
Breast Neoplasms
Assembly of functional ALT-associated promyelocytic leukemia bodies requires Nijmegen Breakage Syndrome 1.
Breast Neoplasms
Association between DNA damage, DNA repair genes variability and clinical characteristics in breast cancer patients.
Breast Neoplasms
Association between RAD51 polymorphism and breast cancer susceptibility: a meta analysis.
Breast Neoplasms
Association between the RAD51 135 G>C Polymorphism and Risk of Cancer: A Meta-Analysis of 19,068 Cases and 22,630 Controls.
Breast Neoplasms
Association of BRCA1, BRCA2, RAD51, and HER2 gene polymorphisms with the breast cancer risk in the Bangladeshi population.
Breast Neoplasms
Association of Rad51 polymorphism with DNA repair in BRCA1 mutation carriers and sporadic breast cancer risk.
Breast Neoplasms
BCCIP regulates homologous recombination by distinct domains and suppresses spontaneous DNA damage.
Breast Neoplasms
BRCA1 and BRCA2 heterozygosity in embryonic stem cells reduces radiation-induced Rad51 focus formation but is not associated with radiosensitivity.
Breast Neoplasms
BRCA2 coordinates the activities of cell-cycle kinases to promote genome stability.
Breast Neoplasms
BRCA2 promotes DNA-RNA hybrid resolution by DDX5 helicase at DNA breaks to facilitate their repair.
Breast Neoplasms
Breast cancer risk and common single nucleotide polymorphisms in homologous recombination DNA repair pathway genes XRCC2, XRCC3, NBS1 and RAD51.
Breast Neoplasms
Breast cancer risk reduction associated with the RAD51 polymorphism among carriers of the BRCA1 5382insC mutation in Poland.
Breast Neoplasms
BSSV: Bayesian based somatic structural variation identification with whole genome DNA-seq data.
Breast Neoplasms
Chinese Herbal Mixture, Tien-Hsien Liquid, Induces G2/M Cycle Arrest and Radiosensitivity in MCF-7 Human Breast Cancer Cells through Mechanisms Involving DNMT1 and Rad51 Downregulation.
Breast Neoplasms
Clinical and biological significance of RAD51 expression in breast cancer: a key DNA damage response protein.
Breast Neoplasms
Combined effect of polymorphisms in Rad51 and Xrcc3 on breast cancer risk and chromosomal radiosensitivity.
Breast Neoplasms
Contribution of germline deleterious variants in the RAD51 paralogs to breast and ovarian cancers.
Breast Neoplasms
Correction for Gasparini et al., Protective role of miR-155 in breast cancer through RAD51 targeting impairs homologous recombination after irradiation.
Breast Neoplasms
Correlation between selected XRCC2, XRCC3 and RAD51 gene polymorphisms and primary breast cancer in women in Pakistan.
Breast Neoplasms
CtBP1 transactivates RAD51 and confers cisplatin resistance to breast cancer cells.
Breast Neoplasms
Curcumin enhances poly(ADP-ribose) polymerase inhibitor sensitivity to chemotherapy in breast cancer cells.
Breast Neoplasms
Design, synthesis and interaction of BRC4 analogous peptides with RAD51(241-260).
Breast Neoplasms
Detection of loss of heterozygosity at RAD51, RAD52, RAD54 and BRCA1 and BRCA2 loci in breast cancer: pathological correlations.
Breast Neoplasms
Differential regulation of DNA repair protein Rad51 in human tumour cell lines exposed to doxorubicin.
Breast Neoplasms
Dinucleotide repeat polymorphisms of RAD51, BRCA1, BRCA2 gene regions in breast cancer.
Breast Neoplasms
DNA Repair Gene Expression and Risk of Locoregional Relapse in Breast Cancer Patients.
Breast Neoplasms
DNA repair polymorphisms might contribute differentially on familial and sporadic breast cancer susceptibility: a study on a Portuguese population.
Breast Neoplasms
Double-strand break repair gene polymorphisms and risk of breast or ovarian cancer.
Breast Neoplasms
DSS1 is required for RAD51 focus formation and genomic stability in mammalian cells.
Breast Neoplasms
Dual PARP and RAD51 Inhibitory Drug Conjugates Show Synergistic and Selective Effects on Breast Cancer Cells.
Breast Neoplasms
E2F1-regulated long non-coding RNA RAD51-AS1 promotes cell cycle progression, inhibits apoptosis and predicts poor prognosis in epithelial ovarian cancer.
Breast Neoplasms
Effect of RAD51C expression on the chemosensitivity of E?-Myc p19Arf-/- cells and its clinical significance in breast cancer.
Breast Neoplasms
Effect of the BRCA2 CTRD domain on RAD51 filaments analyzed by an ensemble of single molecule techniques.
Breast Neoplasms
Evaluation of miRNA-binding-site SNPs of MRE11A, NBS1, RAD51 and RAD52 involved in HRR pathway genes and risk of breast cancer in China.
Breast Neoplasms
Exploring the role of BRCA1, BRCA2 and RAD51 as biomarkers for breast cancer.
Breast Neoplasms
Expression of BRC repeats in breast cancer cells disrupts the BRCA2-Rad51 complex and leads to radiation hypersensitivity and loss of G(2)/M checkpoint control.
Breast Neoplasms
Fanconi anemia complementation group D2 (FANCD2) functions independently of BRCA2- and RAD51-associated homologous recombination in response to DNA damage.
Breast Neoplasms
FIGNL1-containing protein complex is required for efficient homologous recombination repair.
Breast Neoplasms
Full-length archaeal Rad51 structure and mutants: mechanisms for RAD51 assembly and control by BRCA2.
Breast Neoplasms
Functional Ex Vivo Assay Reveals Homologous Recombination Deficiency in Breast Cancer Beyond BRCA Gene Defects.
Breast Neoplasms
Further evidence for the contribution of the RAD51C gene in hereditary breast and ovarian cancer susceptibility.
Breast Neoplasms
Ganetespib overcomes resistance to PARP inhibitors in breast cancer by targeting core proteins in the DNA repair machinery.
Breast Neoplasms
Generation of reactive oxygen species by grape seed extract causes irreparable DNA damage leading to G2/M arrest and apoptosis selectively in head and neck squamous cell carcinoma cells.
Breast Neoplasms
Genetic variants of BLM interact with RAD51 to increase breast cancer susceptibility.
Breast Neoplasms
Genetics polymorphism in DNA repair genes by base excision repair pathway (XRCC1) and homologous recombination (XRCC2 and RAD51) and the risk of breast carcinoma in the Polish population.
Breast Neoplasms
Germline BRCA1 mutations and G/C polymorphism in the 5'-untranslated region of the RAD51 gene in Polish women with breast cancer.
Breast Neoplasms
Germline gene polymorphisms predisposing domestic mammals to carcinogenesis.
Breast Neoplasms
Hereditary breast and ovarian cancer: assessment of point mutations and copy number variations in Brazilian patients.
Breast Neoplasms
High levels of RAD51 perturb DNA replication elongation and cause unscheduled origin firing due to impaired CHK1 activation.
Breast Neoplasms
High RAD51 mRNA expression characterize estrogen receptor-positive/progesteron receptor-negative breast cancer and is associated with patient's outcome.
Breast Neoplasms
Histological groups of human postpubertal testicular germ cell tumours harbour different genetic alterations.
Breast Neoplasms
Homology-directed dna repair, mitomycin-c resistance, and chromosome stability is restored with correction of a Brca1 mutation.
Breast Neoplasms
Homozygous T172T and Heterozygous G135C Variants of Homologous Recombination Repairing Protein RAD51 are Related to Sporadic Breast Cancer Susceptibility.
Breast Neoplasms
Identification of Rad51 alteration in patients with bilateral breast cancer.
Breast Neoplasms
Identification of translationally controlled tumor protein in promotion of DNA homologous recombination repair in cancer cells by affinity proteomics.
Breast Neoplasms
Immunohistochemical expression of DNA repair proteins in familial breast cancer differentiate BRCA2-associated tumors.
Breast Neoplasms
Immunohistochemical prediction of brain metastases in patients with advanced breast cancer: The role of Rad51.
Breast Neoplasms
Inhibition of PTEN activates bovine non-growing follicles in vitro but increases DNA damage and reduces DNA repair response.
Breast Neoplasms
Inhibition of Rad51 sensitizes breast cancer cells with wild-type PTEN to olaparib.
Breast Neoplasms
Insights into DNA recombination from the structure of a RAD51-BRCA2 complex.
Breast Neoplasms
Interactions between canine RAD51 and full length or truncated BRCA2 BRC repeats.
Breast Neoplasms
Interrogation of the Protein-Protein Interactions between Human BRCA2 BRC Repeats and RAD51 Reveals Atomistic Determinants of Affinity.
Breast Neoplasms
Is RAD51 135G>C polymorphism really associated with breast cancer in general population? Biased design and results lead to inappropriate conclusion.
Breast Neoplasms
Jab1/Cops5 contributes to chemoresistance in breast cancer by regulating Rad51.
Breast Neoplasms
JMJD1C demethylates MDC1 to regulate the RNF8 and BRCA1-mediated chromatin response to DNA breaks.
Breast Neoplasms
Landscape of Germline Mutations in DNA Repair Genes for Breast Cancer in Latin America: Opportunities for PARP-Like Inhibitors and Immunotherapy.
Breast Neoplasms
Loss of CtIP disturbs homologous recombination repair and sensitizes breast cancer cells to PARP inhibitors.
Breast Neoplasms
Loss of SIM2s inhibits RAD51 binding and leads to unresolved replication stress.
Breast Neoplasms
MiRNA-binding site functional polymorphisms in DNA repair genes RAD51, RAD52, and XRCC2 and breast cancer risk in Chinese population.
Breast Neoplasms
Molecular characterization of a human BRCA2 homolog in Leishmania donovani.
Breast Neoplasms
Mutation analysis of RAD51L1 (RAD51B/REC2) in multiple-case, non-BRCA1/2 breast cancer families.
Breast Neoplasms
Mutations in the BRCT binding site of BRCA1 result in hyper-recombination.
Breast Neoplasms
Need for clarification of data in the recent meta-analysis about RAD51 135G>C polymorphism and breast cancer risk.
Breast Neoplasms
Network Analysis of RAD51 Proteins in Metazoa and the Evolutionary Relationships With Their Archaeal Homologs.
Breast Neoplasms
Network Meta-Analysis on the Effects of DNA Damage Response-Related Gene Mutations on Overall Survival of Breast Cancer Based on TCGA Database.
Breast Neoplasms
New conflicting results obtained in the subgroup analysis of RAD51 135G>C polymorphism and breast cancer risk.
Breast Neoplasms
Over-expression of wild-type Rad51 correlates with histological grading of invasive ductal breast cancer.
Breast Neoplasms
Pathogenic and likely pathogenic variants in PALB2, CHEK2, and other known breast cancer susceptibility genes among 1054 BRCA-negative Hispanics with breast cancer.
Breast Neoplasms
Polymorphic Variants in 5'-UTR Regions of the RAD51 Gene are Associated With RAD51 Expression and Triple-Negative Breast Cancer (TNBC): A Case-Control Study.
Breast Neoplasms
Polymorphism of the homologous recombination repair genes RAD51 and XRCC3 in breast cancer.
Breast Neoplasms
Polymorphisms and mutations in GSTP1, RAD51, XRCC1 and XRCC3 genes in breast cancer patients.
Breast Neoplasms
Polymorphisms in cancer susceptibility genes XRCC1, RAD51 and TP53 and the risk of breast cancer in Serbian women.
Breast Neoplasms
Polymorphisms in RAD51 and their relation with breast cancer in Saudi females.
Breast Neoplasms
Polymorphisms in RAD51, XRCC2, and XRCC3 are not related to breast cancer risk.
Breast Neoplasms
Polymorphisms of canine BRCA2 BRC repeats affecting interaction with RAD51.
Breast Neoplasms
Prexasertib treatment induces homologous recombination deficiency and synergizes with olaparib in triple-negative breast cancer cells.
Breast Neoplasms
Prodigiosin-induced cytotoxicity involves RAD51 down-regulation through the JNK and p38 MAPK pathways in human breast carcinoma cell lines.
Breast Neoplasms
Protective role of miR-155 in breast cancer through RAD51 targeting impairs homologous recombination after irradiation.
Breast Neoplasms
RAB22 and RAB163/mouse BRCA2: proteins that specifically interact with the RAD51 protein.
Breast Neoplasms
RAD51 135G-->C modifies breast cancer risk among BRCA2 mutation carriers: results from a combined analysis of 19 studies.
Breast Neoplasms
RAD51 135G/C polymorphism and breast cancer risk: a meta-analysis from 21 studies.
Breast Neoplasms
RAD51 135G>C and TP53 Arg72Pro polymorphisms and susceptibility to breast cancer in Serbian women.
Breast Neoplasms
RAD51 135G>C does not modify breast cancer risk in non-BRCA1/2 mutation carriers: evidence from a meta-analysis of 12 studies.
Breast Neoplasms
RAD51 135G>C polymorphism and risk of familial breast cancer in a South American population.
Breast Neoplasms
RAD51 135G>C polymorphism contributes to breast cancer susceptibility: a meta-analysis involving 26,444 subjects.
Breast Neoplasms
RAD51 135G>C substitution increases breast cancer risk in an ethnic-specific manner: a meta-analysis on 21,236 cases and 19,407 controls.
Breast Neoplasms
RAD51 and breast cancer susceptibility: no evidence for rare variant association in the Breast Cancer Family Registry study.
Breast Neoplasms
RAD51 foci as a functional biomarker of homologous recombination repair and PARP inhibitor resistance in germline BRCA-mutated breast cancer.
Breast Neoplasms
RAD51 G135C polymorphism is associated with breast cancer susceptibility: a meta-analysis involving 22,399 subjects.
Breast Neoplasms
RAD51 inhibition in triple negative breast cancer cells is challenged by compensatory survival signaling and requires rational combination therapy.
Breast Neoplasms
Rad51 inhibition sensitizes breast cancer stem cells to PARP inhibitor in triple-negative breast cancer.
Breast Neoplasms
RAD51 interacts with the evolutionarily conserved BRC motifs in the human breast cancer susceptibility gene brca2.
Breast Neoplasms
Rad51 paralogs and the risk of unselected breast cancer: A case-control study.
Breast Neoplasms
RAD51 up-regulation bypasses BRCA1 function and is a common feature of BRCA1-deficient breast tumors.
Breast Neoplasms
RAD51 variant proteins from human lung and kidney tumors exhibit DNA strand exchange defects.
Breast Neoplasms
RAD51, XRCC3, and XRCC2 mutation screening in Finnish breast cancer families.
Breast Neoplasms
RAD51B Activity and Cell Cycle Regulation in Response to DNA Damage in Breast Cancer Cell Lines.
Breast Neoplasms
Relationship between B-Cell-specific moloney murine leukemia virus integration site 1 (BMI-1) and homologous recombination regulatory genes in invasive ductal breast carcinomas.
Breast Neoplasms
Resveratrol decreases Rad51 expression and sensitizes cisplatin?resistant MCF?7 breast cancer cells.
Breast Neoplasms
Same data sources, different pooled analysis result: the ongoing uncertainty in the subgroup analysis of RAD51 135G/C polymorphism and breast cancer risk.
Breast Neoplasms
Sequence fingerprints in BRCA2 and RAD51: implications for DNA repair and cancer.
Breast Neoplasms
Simultaneous ATM/BRCA1/RAD51 expression variations associated with prognostic factors in Iranian sporadic breast cancer patients.
Breast Neoplasms
Single Nucleotide Polymorphisms (SNPs) of RAD51-G172T and XRCC2-41657C/T Homologous Recombination Repair Genes and the Risk of Triple- Negative Breast Cancer in Polish Women.
Breast Neoplasms
Single nucleotide polymorphisms in the homologous recombination repair genes and breast cancer risk in polish women.
Breast Neoplasms
Slug/?-Catenin-Dependent Proinflammatory Phenotype in Hypoxic Breast Cancer Stem Cells.
Breast Neoplasms
Somatic SNPs of the BRCA2 gene at the fragments encoding RAD51 binding sites of canine mammary tumors.
Breast Neoplasms
Spatiotemporal dynamics of homologous recombination repair at single collapsed replication forks.
Breast Neoplasms
Suppression of Homologous Recombination by insulin-like growth factor-1 inhibition sensitizes cancer cells to PARP inhibitors.
Breast Neoplasms
Synthesis, molecular modeling, and biological evaluation of novel RAD51 inhibitors.
Breast Neoplasms
Targeting Cell Cycle Proteins in Breast Cancer Cells with siRNA by Using Lipid-Substituted Polyethylenimines.
Breast Neoplasms
Targeting SMYD3 to Sensitize Homologous Recombination-Proficient Tumors to PARP-Mediated Synthetic Lethality.
Breast Neoplasms
The BRCA1/BRCA2/Rad51 complex is a prognostic and predictive factor in early breast cancer.
Breast Neoplasms
The breast cancer susceptibility gene BRCA1 is required for subnuclear assembly of Rad51 and survival following treatment with the DNA cross-linking agent cisplatin.
Breast Neoplasms
The breast cancer tumor suppressor BRCA2 promotes the specific targeting of RAD51 to single-stranded DNA.
Breast Neoplasms
The carboxyl terminus of Brca2 links the disassembly of Rad51 complexes to mitotic entry.
Breast Neoplasms
The effect of a DNA repair gene on cellular invasiveness: XRCC3 over-expression in breast cancer cells.
Breast Neoplasms
The F-Box Domain-Dependent Activity of EMI1 Regulates PARPi Sensitivity in Triple-Negative Breast Cancers.
Breast Neoplasms
The RAD51 135 G>C polymorphism modifies breast cancer and ovarian cancer risk in Polish BRCA1 mutation carriers.
Breast Neoplasms
The RAD51 135G>C polymorphism is related to the effect of adjuvant therapy in early breast cancer.
Breast Neoplasms
The Tumor-Associated Variant RAD51 G151D Induces a Hyper-Recombination Phenotype.
Breast Neoplasms
The Valproate Mediates Radio-Bidirectional Regulation Through RFWD3-Dependent Ubiquitination on Rad51.
Breast Neoplasms
TODRA, a lncRNA at the RAD51 Locus, Is Oppositely Regulated to RAD51, and Enhances RAD51-Dependent DSB (Double Strand Break) Repair.
Breast Neoplasms
Towards rational design of RAD51-targeting prodrugs: platinumIV-artesunate conjugates with enhanced cytotoxicity against BRCA-proficient ovarian and breast cancer cells.
Breast Neoplasms
TP53 Binding to BRCA1 and RAD51 in MCF7 and MDA-MB-468 Breast Cancer Cell Lines In vivo and In vitro.
Breast Neoplasms
Tumor-associated mutations in a conserved structural motif alter physical and biochemical properties of human RAD51 recombinase.
Breast Neoplasms
Utility of DNA repair protein foci for the detection of putative BRCA1 pathway defects in breast cancer biopsies.
Breast Neoplasms
Variants in DNA double-strand break repair genes and breast cancer susceptibility.
Breast Neoplasms
Whole-exome sequencing reveals germline-mutated small cell lung cancer subtype with favorable response to DNA repair-targeted therapies.
Breast Neoplasms
XRCC1 Arg399Gln and RAD51 5'UTR G135C polymorphisms and their outcome in tumor aggressiveness and survival of Portuguese breast cancer patients.
Breast Neoplasms
XRCC3 and RAD51 Expression Are Associated with Clinical Factors in Breast Cancer.
Carcinogenesis
A distinct replication fork protection pathway connects Fanconi anemia tumor suppressors to RAD51-BRCA1/2.
Carcinogenesis
Analysis of functional hub genes identifies CDC45 as an oncogene in non-small cell lung cancer - a short report.
Carcinogenesis
BRCA1 regulates RAD51 function in response to DNA damage and suppresses spontaneous sister chromatid replication slippage: implications for sister chromatid cohesion, genome stability, and carcinogenesis.
Carcinogenesis
BRCA2 coordinates the activities of cell-cycle kinases to promote genome stability.
Carcinogenesis
CDK7 inhibitor suppresses tumor progression through blocking the cell cycle at the G2/M phase and inhibiting transcriptional activity in cervical cancer.
Carcinogenesis
Design, synthesis and interaction of BRC4 analogous peptides with RAD51(241-260).
Carcinogenesis
DIDS, a chemical compound that inhibits RAD51-mediated homologous pairing and strand exchange.
Carcinogenesis
Epigenetic therapy using the histone deacetylase inhibitor for increasing therapeutic gain in oral cancer: Prevention of radiation-induced oral mucositis and inhibition of chemical-induced oral carcinogenesis.
Carcinogenesis
Genome-wide search for loss of heterozygosity using laser capture microdissected tissue of breast carcinoma: an implication for mutator phenotype and breast cancer pathogenesis.
Carcinogenesis
Halenaquinone, a chemical compound that specifically inhibits the secondary DNA binding of RAD51.
Carcinogenesis
HELQ promotes RAD51 paralogue-dependent repair to avert germ cell loss and tumorigenesis.
Carcinogenesis
High levels of RAD51 perturb DNA replication elongation and cause unscheduled origin firing due to impaired CHK1 activation.
Carcinogenesis
Homologous recombination repair signaling in chemical carcinogenesis: prolonged particulate hexavalent chromium exposure suppresses the Rad51 response in human lung cells.
Carcinogenesis
Inhibition of autophagy aggravates DNA damage response and gastric tumorigenesis via Rad51 ubiquitination in response to H. pylori infection.
Carcinogenesis
Mammalian RAD51 paralogs protect nascent DNA at stalled forks and mediate replication restart.
Carcinogenesis
Overexpression of mammalian Rad51 does not stimulate tumorigenesis while a dominant-negative Rad51 affects centrosome fragmentation, ploidy and stimulates tumorigenesis, in p53-defective CHO cells.
Carcinogenesis
Progressing from Recurring Tissue Injury to Genomic Instability: A New Mechanism of Neutrophil Pathogenesis.
Carcinogenesis
RAD51 as a candidate parathyroid tumour suppressor gene on chromosome 15q: absence of somatic mutations.
Carcinogenesis
RAD51 as a potential biomarker and therapeutic target for pancreatic cancer.
Carcinogenesis
RAD51 paralogs: Roles in DNA damage signalling, recombinational repair and tumorigenesis.
Carcinogenesis
Targeting NEK2 impairs oncogenesis and radioresistance via inhibiting the Wnt1/?-catenin signaling pathway in cervical cancer.
Carcinogenesis
The homologous recombination protein RAD51D protects the genome from large deletions.
Carcinogenesis
The level of secretory leukocyte protease inhibitor is decreased in metastatic head and neck squamous cell carcinoma.
Carcinogenesis
The role of microRNA-binding site polymorphisms in DNA repair genes as risk factors for bladder cancer and breast cancer and their impact on radiotherapy outcomes.
Carcinogenesis
The Valproate Mediates Radio-Bidirectional Regulation Through RFWD3-Dependent Ubiquitination on Rad51.
Carcinogenesis
[Expression of RAD51 in carcinomas of cancer of larynx and its clinical significance]
Carcinoma
172G>T variant in the 5' untranslated region of DNA repair gene RAD51 reduces risk of squamous cell carcinoma of the head and neck and interacts with a P53 codon 72 variant.
Carcinoma
Analysis of DNA Damage Response Gene Alterations and Tumor Mutational Burden Across 17,486 Tubular Gastrointestinal Carcinomas: Implications for Therapy.
Carcinoma
Association between polymorphisms of the DNA repair gene RAD51 and ovarian cancer.
Carcinoma
Association between single nucleotide polymorphisms in the XRCC1 and RAD51 genes and clinical radiosensitivity in head and neck cancer.
Carcinoma
Astaxanthin down-regulates Rad51 expression via inactivation of AKT kinase to enhance mitomycin C-induced cytotoxicity in human non-small cell lung cancer cells.
Carcinoma
Clinicopathological significance of SNPs in RAD51 and XRCC3 in oral and oropharyngeal carcinomas.
Carcinoma
Combined evaluation of Rad51 and ERCC1 expressions for sensitivity to platinum agents in non-small cell lung cancer.
Carcinoma
Curcumin enhances the mitomycin C-induced cytotoxicity via downregulation of MKK1/2-ERK1/2-mediated Rad51 expression in non-small cell lung cancer cells.
Carcinoma
DNA repair and cytotoxic drugs: the potential role of RAD51 in clinical outcome of non-small-cell lung cancer patients.
Carcinoma
DNA Repair Protein Rad51 Induces Tumor Growth and Metastasis in Esophageal Squamous Cell Carcinoma via a p38/Akt-Dependent Pathway.
Carcinoma
Elevated expression of Rad51 is correlated with decreased survival in resectable esophageal squamous cell carcinoma.
Carcinoma
Equivocal association of RAD51 polymorphisms with risk of esophageal squamous cell carcinoma in a Chinese population.
Carcinoma
Erratum to: Rad51 Expression Is a Useful Predictive Factor for the Efficacy of Neoadjuvant Chemoradiotherapy in Squamous Cell Carcinoma of the Esophagus.
Carcinoma
Impact of RAD51 G135C and XRCC1 Arg399Gln polymorphisms on ovarian carcinoma risk in Serbian women.
Carcinoma
Increased expression of human DNA repair genes, XRCC1, XRCC3 and RAD51, in radioresistant human KB carcinoma cell line N10.
Carcinoma
Induction of Rad51 protein levels by p38 MAPK decreases cytotoxicity and mutagenicity in benzo[a]pyrene-exposed human lung cancer cells.
Carcinoma
Involvement of Rad51 in cytotoxicity induced by epidermal growth factor receptor inhibitor (gefitinib, IressaR) and chemotherapeutic agents in human lung cancer cells.
Carcinoma
Minocycline enhances mitomycin C-induced cytotoxicity through down-regulating ERK1/2-mediated Rad51 expression in human non-small cell lung cancer cells.
Carcinoma
Predictive biomarkers for sacituzumab govitecan efficacy in Trop-2-expressing triple-negative breast cancer.
Carcinoma
Prognostic significance of head and neck squamous cell carcinoma repair gene polymorphism.
Carcinoma
Prognostic value of tumor-infiltrating lymphocytes (TILs) and their association with PD-L1 expression and DNA repair protein RAD51 in patients with resected non-small cell lung carcinoma.
Carcinoma
RAD51 Expression as a Biomarker to Predict Efficacy of Preoperative Therapy and Survival for Esophageal Squamous Cell Carcinoma: A Large-cohort Observational Study (KSCC1307).
Carcinoma
Rad51 Expression Is a Useful Predictive Factor for the Efficacy of Neoadjuvant Chemoradiotherapy in Squamous Cell Carcinoma of the Esophagus.
Carcinoma
RAD51 Gene 135G/C polymorphism and the risk of four types of common cancers: a meta-analysis.
Carcinoma
Role of Rad51 down-regulation and extracellular signal-regulated kinases 1 and 2 inactivation in emodin and mitomycin C-induced synergistic cytotoxicity in human non-small-cell lung cancer cells.
Carcinoma
Role of repair protein Rad51 in regulating the response to gefitinib in human non-small cell lung cancer cells.
Carcinoma
Susceptibility of XPD and RAD51 Genetic Variants to Carcinoma of Urinary Bladder in North Indian Population.
Carcinoma
The homologous recombination protein RAD51 is a promising therapeutic target for cervical carcinoma.
Carcinoma
The RAD51-FFPE Test; Calibration of a Functional Homologous Recombination Deficiency Test on Diagnostic Endometrial and Ovarian Tumor Blocks.
Carcinoma
The RECAP Test Rapidly and Reliably Identifies Homologous Recombination-Deficient Ovarian Carcinomas.
Carcinoma
The role of celecoxib in Rad51 expression and cell survival affected by gefitinib in human non-small cell lung cancer cells.
Carcinoma
The role of repair protein Rad51 in synergistic cytotoxicity and mutagenicity induced by epidermal growth factor receptor inhibitor (Gefitinib, IressaR) and benzo[a]pyrene in human lung cancer.
Carcinoma
[Expression of RAD51 in carcinomas of cancer of larynx and its clinical significance]
Carcinoma, Hepatocellular
Genetic inactivation of the Fanconi anemia gene FANCC identified in the hepatocellular carcinoma cell line HuH-7 confers sensitivity towards DNA-interstrand crosslinking agents.
Carcinoma, Hepatocellular
Harmine suppresses homologous recombination repair and inhibits proliferation of hepatoma cells.
Carcinoma, Hepatocellular
Hepatitis B virus X protein promotes DNA damage propagation through disruption of liver polyploidization and enhances hepatocellular carcinoma initiation.
Carcinoma, Hepatocellular
Identification of Rad51 as a prognostic biomarker correlated with immune infiltration in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Lack of association of RAD51 genetic variations with hepatitis B virus clearance and occurrence of hepatocellular carcinoma in a Korean population.
Carcinoma, Non-Small-Cell Lung
(-)-Guaiol regulates RAD51 stability via autophagy to induce cell apoptosis in non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Astaxanthin down-regulates Rad51 expression via inactivation of AKT kinase to enhance mitomycin C-induced cytotoxicity in human non-small cell lung cancer cells.
Carcinoma, Non-Small-Cell Lung
Combined evaluation of Rad51 and ERCC1 expressions for sensitivity to platinum agents in non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Combining carbon ion irradiation and non-homologous end-joining repair inhibitor NU7026 efficiently kills cancer cells.
Carcinoma, Non-Small-Cell Lung
Curcumin enhances the mitomycin C-induced cytotoxicity via downregulation of MKK1/2-ERK1/2-mediated Rad51 expression in non-small cell lung cancer cells.
Carcinoma, Non-Small-Cell Lung
DNA repair and cytotoxic drugs: the potential role of RAD51 in clinical outcome of non-small-cell lung cancer patients.
Carcinoma, Non-Small-Cell Lung
DNA replication stress response involving PLK1, CDC6, POLQ, RAD51 and CLASPIN upregulation prognoses the outcome of early/mid-stage non-small cell lung cancer patients.
Carcinoma, Non-Small-Cell Lung
Downregulation of Rad51 expression overcomes drug resistance to gemcitabine in human non-small cell lung cancer cells.
Carcinoma, Non-Small-Cell Lung
Effects of emodin extracted from Chinese herbs on proliferation of non-small cell lung cancer and underlying mechanisms.
Carcinoma, Non-Small-Cell Lung
HSP90 inhibition induces cytotoxicity via down-regulation of Rad51 expression and DNA repair capacity in non-small cell lung cancer cells.
Carcinoma, Non-Small-Cell Lung
Influence of DNA repair RAD51 gene variants in overall survival of non-small cell lung cancer patients treated with first line chemotherapy.
Carcinoma, Non-Small-Cell Lung
KIF5B-EGFR Fusion: A Novel EGFR Mutation in Lung Adenocarcinoma.
Carcinoma, Non-Small-Cell Lung
Minocycline enhances mitomycin C-induced cytotoxicity through down-regulating ERK1/2-mediated Rad51 expression in human non-small cell lung cancer cells.
Carcinoma, Non-Small-Cell Lung
Modulation of Rad51, ERCC1, and thymidine phosphorylase by emodin result in synergistic cytotoxic effect in combination with capecitabine.
Carcinoma, Non-Small-Cell Lung
Prognostic and predictive value of loss of nuclear RAD51 immunoreactivity in resected non-small cell lung cancer patients.
Carcinoma, Non-Small-Cell Lung
Prognostic value of tumor-infiltrating lymphocytes (TILs) and their association with PD-L1 expression and DNA repair protein RAD51 in patients with resected non-small cell lung carcinoma.
Carcinoma, Non-Small-Cell Lung
Rad51 in regulating the radiosensitivity of non-small cell lung cancer with different epidermal growth factor receptor mutation status.
Carcinoma, Non-Small-Cell Lung
Role of repair protein Rad51 in regulating the response to gefitinib in human non-small cell lung cancer cells.
Carcinoma, Non-Small-Cell Lung
Roles of MKK1/2-ERK1/2 and phosphoinositide 3-kinase-AKT signaling pathways in erlotinib-induced Rad51 suppression and cytotoxicity in human non-small cell lung cancer cells.
Carcinoma, Non-Small-Cell Lung
Suppression of ERCC1 and Rad51 expression through ERK1/2 inactivation is essential in emodin-mediated cytotoxicity in human non-small cell lung cancer cells.
Carcinoma, Non-Small-Cell Lung
The impact of functional LIG4 polymorphism on platinum-based chemotherapy response and survival in non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
The role of celecoxib in Rad51 expression and cell survival affected by gefitinib in human non-small cell lung cancer cells.
Carcinoma, Ovarian Epithelial
The RECAP Test Rapidly and Reliably Identifies Homologous Recombination-Deficient Ovarian Carcinomas.
Carcinoma, Squamous Cell
172G>T variant in the 5' untranslated region of DNA repair gene RAD51 reduces risk of squamous cell carcinoma of the head and neck and interacts with a P53 codon 72 variant.
Carcinoma, Squamous Cell
Association between single nucleotide polymorphisms in the XRCC1 and RAD51 genes and clinical radiosensitivity in head and neck cancer.
Carcinoma, Squamous Cell
Clinicopathological significance of SNPs in RAD51 and XRCC3 in oral and oropharyngeal carcinomas.
Carcinoma, Squamous Cell
Combined evaluation of Rad51 and ERCC1 expressions for sensitivity to platinum agents in non-small cell lung cancer.
Carcinoma, Squamous Cell
Erratum to: Rad51 Expression Is a Useful Predictive Factor for the Efficacy of Neoadjuvant Chemoradiotherapy in Squamous Cell Carcinoma of the Esophagus.
Carcinoma, Squamous Cell
Expression of RAD51 and Its Clinical Impact in Oral Squamous Cell Carcinoma.
Carcinoma, Squamous Cell
Prognostic significance of head and neck squamous cell carcinoma repair gene polymorphism.
Carcinoma, Squamous Cell
Rad51 Expression Is a Useful Predictive Factor for the Efficacy of Neoadjuvant Chemoradiotherapy in Squamous Cell Carcinoma of the Esophagus.
Carcinoma, Squamous Cell
RAD51 Gene 135G/C polymorphism and the risk of four types of common cancers: a meta-analysis.
Carcinoma, Squamous Cell
RAD51 regulates CHK1 stability via autophagy to promote cell growth in esophageal squamous carcinoma cells.
Cardiomyopathies
Disparate Impact of Butyroyloxymethyl Diethylphosphate (AN-7), a Histone Deacetylase Inhibitor, and Doxorubicin in Mice Bearing a Mammary Tumor.
Chagas Disease
Characterization of the Trypanosoma cruzi Rad51 gene and its role in recombination events associated with the parasite resistance to ionizing radiation.
Chagas Disease
The in vivo and in vitro roles of Trypanosoma cruzi Rad51 in the repair of DNA double strand breaks and oxidative lesions.
Cholangiocarcinoma
Enhanced expression of RAD51 associating protein-1 is involved in the growth of intrahepatic cholangiocarcinoma cells.
Chondrosarcoma
Combination BET Family Protein and HDAC Inhibition Synergistically Elicits Chondrosarcoma Cell Apoptosis Through RAD51-Related DNA Damage Repair.
Chordoma
Radioresistance of chordoma cells is associated with the ATM/ATR pathway, in which RAD51 serves as an important downstream effector.
Choriocarcinoma
Methotrexate induces DNA damage and inhibits homologous recombination repair in choriocarcinoma cells.
Cleft Lip
Interactions between RAD51 rs1801321 and maternal cigarette smoking as risk factor for nonsyndromic cleft lip with or without cleft palate.
Cleft Palate
Interactions between RAD51 rs1801321 and maternal cigarette smoking as risk factor for nonsyndromic cleft lip with or without cleft palate.
Cockayne Syndrome
DNA damage during the G0/G1 phase triggers RNA-templated, Cockayne syndrome B-dependent homologous recombination.
Cockayne Syndrome
ROS-induced R loops trigger a transcription-coupled but BRCA1/2-independent homologous recombination pathway through CSB.
Colonic Neoplasms
A novel function of hepatocyte growth factor in the activation of checkpoint kinase 1 phosphorylation in colon cancer cells.
Colonic Neoplasms
Common fragile sites in colon cancer cell lines: role of mismatch repair, RAD51 and poly(ADP-ribose) polymerase-1.
Colonic Neoplasms
GAIP-interacting protein, C-terminus is involved in the induction of zinc-finger protein 143 in response to insulin-like growth factor-1 in colon cancer cells.
Colonic Neoplasms
Interaction between RAD51 and MCM Complex Is Essential for RAD51 Foci Forming in Colon Cancer HCT116 Cells.
Colonic Neoplasms
Mitotic crossover--an evolutionary rudiment which promotes carcinogenesis of colorectal carcinoma.
Colonic Neoplasms
p53 is involved in clearance of ionizing radiation-induced RAD51 foci in a human colon cancer cell line.
Colonic Neoplasms
The effect of polymorphism in DNA repair genes RAD51 and XRCC2 in colorectal cancer in Turkish population.
Colonic Neoplasms
The use of olaparib (AZD2281) potentiates SN-38 cytotoxicity in colon cancer cells by indirect inhibition of Rad51-mediated repair of DNA double-strand breaks.
Colorectal Neoplasms
A review on role of ATM gene in hereditary transfer of colorectal cancer.
Colorectal Neoplasms
Alpinumisoflavone causes DNA damage in Colorectal Cancer Cells via blocking DNA repair mediated by RAD51.
Colorectal Neoplasms
Clinicopathological and Prognostic Characteristics of RAD51 in Colorectal Cancer.
Colorectal Neoplasms
Control of replication stress and mitosis in colorectal cancer stem cells through the interplay of PARP1, MRE11 and RAD51.
Colorectal Neoplasms
Evaluation of pharmacodynamic responses to cancer therapeutic agents using DNA damage markers.
Colorectal Neoplasms
Genetic Variations of RAD51 and XRCC2 Genes Increase the Risk of Colorectal Cancer in Bangladeshi Population.
Colorectal Neoplasms
Lack of Association Between the 135G/C Rad51 Gene Polymorphism and the Risk of Colorectal Cancer Among Polish Population.
Colorectal Neoplasms
Overexpression of Rad51 Predicts Poor Prognosis in Colorectal Cancer: Our Experience with 54 Patients.
Colorectal Neoplasms
Polymorphism RAD51 172G > T in Serbian patients with colorectal cancer.
Colorectal Neoplasms
Polymorphism within the distal RAD51 gene promoter is associated with colorectal cancer in a Polish population.
Colorectal Neoplasms
Polymorphisms in RAD51, XRCC2 and XRCC3 genes of the homologous recombination repair in colorectal cancer-a case control study.
Colorectal Neoplasms
RAD51 135G>C polymorphism and risk of sporadic colorectal cancer in Iranian population.
Colorectal Neoplasms
RAD51 G135C gene polymorphism and risk of colorectal cancer in Kashmir.
Colorectal Neoplasms
RAD51 Gene 135G/C polymorphism and the risk of four types of common cancers: a meta-analysis.
Colorectal Neoplasms
RAD51 gene polymorphisms and sporadic colorectal cancer risk in Poland.
Colorectal Neoplasms
Retraction: Overexpression of Rad51 Predicts Poor Prognosis in Colorectal Cancer: Our Experience with 54 Patients.
Colorectal Neoplasms
Suppression of homologous recombination sensitizes human tumor cells to IGF-1R inhibition.
Colorectal Neoplasms
The effect of polymorphism in DNA repair genes RAD51 and XRCC2 in colorectal cancer in Turkish population.
Colorectal Neoplasms
The mammalian mismatch repair protein MSH2 is required for correct MRE11 and RAD51 relocalization and for efficient cell cycle arrest induced by ionizing radiation in G2 phase.
Colorectal Neoplasms
The Targeting of MRE11 or RAD51 Sensitizes Colorectal Cancer Stem Cells to CHK1 Inhibition.
Colorectal Neoplasms
XPG Asp1104His, XRCC2 Rs3218536 A/G and RAD51 135G/C Gene Polymorphisms and Colorectal Cancer Risk: A Meta-Analysis
Colorectal Neoplasms
[The role of RAD 51 gene polymorphism in patients with colorectal cancer in the Polish subpopulation]
Colorectal Neoplasms, Hereditary Nonpolyposis
Hereditary ovarian cancer: not only BRCA 1 and 2 genes.
Colorectal Neoplasms, Hereditary Nonpolyposis
Ovarian cancer predisposition beyond BRCA1 and BRCA2 genes.
Corneal Dystrophies, Hereditary
Polymorphisms of the homologous recombination gene RAD51 in keratoconus and Fuchs endothelial corneal dystrophy.
Diphtheria
Rad51 promoter-targeted gene therapy is effective for in vivo visualization and treatment of cancer.
dna 3'-5' helicase deficiency
Human RECQ5 helicase promotes repair of DNA double-strand breaks by synthesis-dependent strand annealing.
DNA Repair-Deficiency Disorders
Clinical Activity and Safety of Cediranib and Olaparib Combination in Patients with Metastatic Pancreatic Ductal Adenocarcinoma without BRCA Mutation.
DNA Repair-Deficiency Disorders
Prognostic and predictive value of loss of nuclear RAD51 immunoreactivity in resected non-small cell lung cancer patients.
Endometrial Neoplasms
135G>C and 172G>T polymorphism in the 5' untranslated region of RAD51 and sporadic endometrial cancer risk in Polish women.
Endometrial Neoplasms
Association of polymorphisms in the 5' untranslated region of RAD51 gene with risk of endometrial cancer in the Polish population.
Endometrial Neoplasms
DNA damage and repair in endometrial cancer in correlation with the hOGG1 and RAD51 genes polymorphism.
Endometrial Neoplasms
Frequent Homologous Recombination Deficiency in High-grade Endometrial Carcinomas.
Endometrial Neoplasms
Inhibition of PI3K-AKT-mTOR pathway sensitizes endometrial cancer cell lines to PARP inhibitors.
Endometrial Neoplasms
OTUB2 Promotes Homologous Recombination Repair Through Stimulating Rad51 Expression in Endometrial Cancer.
Endometrial Neoplasms
Precision medicine phase II study evaluating the efficacy of a double immunotherapy by durvalumab and tremelimumab combined with olaparib in patients with solid cancers and carriers of homologous recombination repair genes mutation in response or stable after olaparib treatment.
Endometrial Neoplasms
Single nucleotide polymorphisms of RAD51 G135C, XRCC2 Arg188His and XRCC3 Thr241Met homologous recombination repair genes and the risk of sporadic endometrial cancer in Polish women.
Endometriosis
Association Between Impairment of DNA Double Strand Break Repair and Decreased Ovarian Reserve in Patients With Endometriosis.
Esophageal Neoplasms
Berberine Radiosensitizes Human Esophageal Cancer Cells by Downregulating Homologous Recombination Repair Protein RAD51.
Esophageal Neoplasms
CDKN3 promotes tumor progression and confers cisplatin resistance via RAD51 in esophageal cancer.
Esophageal Neoplasms
DNA Repair Protein Rad51 Induces Tumor Growth and Metastasis in Esophageal Squamous Cell Carcinoma via a p38/Akt-Dependent Pathway.
Esophageal Neoplasms
Genetic Polymorphisms in the RAD51 Gene with a Risk of Head and Neck Cancer and Esophageal Cancer: A Meta-Analysis.
Esophageal Neoplasms
Genetic variants of the DNA damage repair genes XRCC4 and RAD51 are associated with susceptibility to esophageal cancer.
Esophageal Neoplasms
Involvement of homologous recombination in the synergism between cisplatin and poly(ADP-ribose) polymerase inhibition.
Esophageal Neoplasms
MiroRNA-127-3p targets XRCC3 to enhance the chemosensitivity of esophageal cancer cells to a novel phenanthroline-dione derivative.
Esophageal Neoplasms
RAD51 regulates CHK1 stability via autophagy to promote cell growth in esophageal squamous carcinoma cells.
Esophageal Neoplasms
[The study of esophageal cancer risk associated with polymorphisms of DNA damage repair genes XRCC4 and RAD51].
Esophageal Squamous Cell Carcinoma
DNA Repair Protein Rad51 Induces Tumor Growth and Metastasis in Esophageal Squamous Cell Carcinoma via a p38/Akt-Dependent Pathway.
Esophageal Squamous Cell Carcinoma
Elevated expression of Rad51 is correlated with decreased survival in resectable esophageal squamous cell carcinoma.
Esophageal Squamous Cell Carcinoma
Equivocal association of RAD51 polymorphisms with risk of esophageal squamous cell carcinoma in a Chinese population.
Esophageal Squamous Cell Carcinoma
RAD51 Expression as a Biomarker to Predict Efficacy of Preoperative Therapy and Survival for Esophageal Squamous Cell Carcinoma: A Large-cohort Observational Study (KSCC1307).
Fanconi Anemia
A novel Fanconi anaemia subtype associated with a dominant-negative mutation in RAD51.
Fanconi Anemia
Attenuation of the formation of DNA-repair foci containing RAD51 in Fanconi anaemia.
Fanconi Anemia
Differential Requirements for the RAD51 Paralogs in Genome Repair and Maintenance in Human Cells.
Fanconi Anemia
Distinct roles of FANCO/RAD51C protein in DNA damage signaling and repair: implications for Fanconi anemia and breast cancer susceptibility.
Fanconi Anemia
Further evidence for the contribution of the RAD51C gene in hereditary breast and ovarian cancer susceptibility.
Fanconi Anemia
Genome-wide profiling of genetic synthetic lethality identifies CDK12 as a novel determinant of PARP1/2 inhibitor sensitivity.
Fanconi Anemia
HCLK2 is essential for the mammalian S-phase checkpoint and impacts on Chk1 stability.
Fanconi Anemia
HELQ promotes RAD51 paralogue-dependent repair to avert germ cell loss and tumorigenesis.
Fanconi Anemia
Identification of Rad51 as a prognostic biomarker correlated with immune infiltration in hepatocellular carcinoma.
Fanconi Anemia
Impaired DNA damage-induced nuclear Rad51 foci formation uniquely characterizes Fanconi anemia group D1.
Fanconi Anemia
Inducibility of nuclear Rad51 foci after DNA damage distinguishes all Fanconi anemia complementation groups from D1/BRCA2.
Fanconi Anemia
Promotion of presynaptic filament assembly by the ensemble of S. cerevisiae Rad51 paralogues with Rad52.
Fanconi Anemia
Reduced FANCD2 influences spontaneous SCE and RAD51 foci formation in uveal melanoma and Fanconi anaemia.
Fanconi Anemia
S-phase-specific interaction of the Fanconi anemia protein, FANCD2, with BRCA1 and RAD51.
Fanconi Anemia
Zalypsis displays preclinical activity in acute myeloid blasts and leukemic progenitor cells through the induction of a DNA damage response.
Fuchs' Endothelial Dystrophy
Polymorphisms of the homologous recombination gene RAD51 in keratoconus and Fuchs endothelial corneal dystrophy.
Gastrointestinal Stromal Tumors
Inhibition of AKT-Signaling Sensitizes Soft Tissue Sarcomas (STS) and Gastrointestinal Stromal Tumors (GIST) to Doxorubicin via Targeting of Homology-Mediated DNA Repair.
Glioblastoma
A multiplexed bioluminescent reporter for sensitive and non-invasive tracking of DNA double strand break repair dynamics in vitro and in vivo.
Glioblastoma
A radiosensitizing effect of RAD51 inhibition in glioblastoma stem-like cells.
Glioblastoma
Ape1 guides DNA repair pathway choice that is associated with drug tolerance in glioblastoma.
Glioblastoma
CD81 Enhances Radioresistance of Glioblastoma by Promoting Nuclear Translocation of Rad51.
Glioblastoma
Cell Cycle Changes after Glioblastoma Stem Cell Irradiation: The Major Role of RAD51.
Glioblastoma
Endoplasmic reticulum stress-inducing drugs sensitize glioma cells to temozolomide through downregulation of MGMT, MPG, and Rad51.
Glioblastoma
Epidermal growth factor receptor mutation status and rad51 determine the response of glioblastoma to multimodality therapy with cetuximab, temozolomide, and radiation.
Glioblastoma
FoxM1 Inhibition Sensitizes Resistant Glioblastoma Cells to Temozolomide by Downregulating the Expression of DNA Repair Gene Rad51.
Glioblastoma
Functional characterization of RebL1 highlights the evolutionary conservation of oncogenic activities of the RBBP4/7 orthologue in Tetrahymena thermophila.
Glioblastoma
Modulation of homology-directed repair in T98G glioblastoma cells due to interactions between wildtype p53, Rad51 and HCMV IE1-72.
Glioblastoma
N6-Isopentenyladenosine Enhances the Radiosensitivity of Glioblastoma Cells by Inhibiting the Homologous Recombination Repair Protein RAD51 Expression.
Glioblastoma
Rad51 Degradation: Role in Oncolytic Virus-Poly(ADP-Ribose) Polymerase Inhibitor Combination Therapy in Glioblastoma.
Glioblastoma
Rad51 protein expression and survival in patients with glioblastoma multiforme.
Glioblastoma
RAD51-Mediated DNA Homologous Recombination Is Independent of PTEN Mutational Status.
Glioma
A multiplexed bioluminescent reporter for sensitive and non-invasive tracking of DNA double strand break repair dynamics in vitro and in vivo.
Glioma
Artesunate induces oxidative DNA damage, sustained DNA double-strand breaks, and the ATM/ATR damage response in cancer cells.
Glioma
Association of XRCC3 rs1799794 polymorphism with survival of glioblastoma multiforme patients treated with combined radio-chemotherapy.
Glioma
Endoplasmic reticulum stress-inducing drugs sensitize glioma cells to temozolomide through downregulation of MGMT, MPG, and Rad51.
Glioma
Gleevec-mediated inhibition of Rad51 expression and enhancement of tumor cell radiosensitivity.
Glioma
HSV-1 amplicon-mediated post-transcriptional inhibition of Rad51 sensitizes human glioma cells to ionizing radiation.
Glioma
In vitro and in vivo potentiation of radiosensitivity of malignant gliomas by antisense inhibition of the RAD51 gene.
Glioma
Integrin ?V?3 silencing sensitizes malignant glioma cells to temozolomide by suppression of homologous recombination repair.
Glioma
Rad51 and BRCA2--New molecular targets for sensitizing glioma cells to alkylating anticancer drugs.
Glioma
Rad51 inhibition is an effective means of targeting DNA repair in glioma models and CD133+ tumor derived cells.
Glioma
Targeting homologous recombination by pharmacological inhibitors enhances the killing response of glioblastoma cells treated with alkylating drugs.
Glioma
[RAD51 promotes proliferation and migration of glioblastoma cells and decreases sensitivity of cells to temozolomide].
Head and Neck Neoplasms
Association between RAD51 polymorphisms and susceptibility of head and neck cancer: a meta-analysis.
Head and Neck Neoplasms
Association between single nucleotide polymorphisms in the XRCC1 and RAD51 genes and clinical radiosensitivity in head and neck cancer.
Head and Neck Neoplasms
Association of XRCC3 C722T and RAD51 G135C polymorphisms with head and neck cancer susceptibility in a Polish population.
Head and Neck Neoplasms
Genetic Polymorphisms in the RAD51 Gene with a Risk of Head and Neck Cancer and Esophageal Cancer: A Meta-Analysis.
Head and Neck Neoplasms
Genetic variability of Xrcc3 and Rad51 modulates the risk of head and neck cancer.
Head and Neck Neoplasms
Pilot study examining tumor expression of RAD51 and clinical outcomes in human head cancers.
Head and Neck Neoplasms
Polymorphisms of the XRCC3 C722T and the RAD51 G135C genes and the risk of head and neck cancer in a Polish population" by Sliwinski et al. published in Experimental and Molecular Pathology, 2010 Dec; 89 (3): 358-66.
Head and Neck Neoplasms
Polymorphisms of the XRCC3 C722T and the RAD51 G135C genes and the risk of head and neck cancer in a Polish population.
Hepatitis
Lack of association of RAD51 genetic variations with hepatitis B virus clearance and occurrence of hepatocellular carcinoma in a Korean population.
Hepatitis B
Lack of association of RAD51 genetic variations with hepatitis B virus clearance and occurrence of hepatocellular carcinoma in a Korean population.
Hepatitis C
Rad51 Interacts with Non-structural 3 Protein of Hepatitis C Virus and Regulates Viral Production.
Herpes Simplex
HSV-1 amplicon-mediated post-transcriptional inhibition of Rad51 sensitizes human glioma cells to ionizing radiation.
Herpes Simplex
Rad51 and Rad52 are involved in homologous recombination of replicating herpes simplex virus DNA.
Herpes Simplex
Recruitment of cellular recombination and repair proteins to sites of herpes simplex virus type 1 DNA replication is dependent on the composition of viral proteins within prereplicative sites and correlates with the induction of the DNA damage response.
Histiocytic Sarcoma
Germline gene polymorphisms predisposing domestic mammals to carcinogenesis.
HIV Infections
Chromosomal integration of LTR-flanked DNA in yeast expressing HIV-1 integrase: down regulation by RAD51.
Hyperparathyroidism, Primary
RAD51 as a candidate parathyroid tumour suppressor gene on chromosome 15q: absence of somatic mutations.
Hypersensitivity
A novel role for the mono-ADP-ribosyltransferase PARP14/ARTD8 in promoting homologous recombination and protecting against replication stress.
Hypersensitivity
A PP4 phosphatase complex dephosphorylates RPA2 to facilitate DNA repair via homologous recombination.
Hypersensitivity
A Short BRCA2-Derived Cell-Penetrating Peptide Targets RAD51 Function and Confers Hypersensitivity toward PARP Inhibition.
Hypersensitivity
A syngeneic variance library for functional annotation of human variation: application to BRCA2.
Hypersensitivity
Ablation of the Brca1-Palb2 Interaction Phenocopies Fanconi Anemia in Mice.
Hypersensitivity
Atmospheric-pressure plasma jet induces DNA double-strand breaks that require a Rad51-mediated homologous recombination for repair in Saccharomyces cerevisiae.
Hypersensitivity
c-Abl tyrosine kinase is not essential for ataxia telangiectasia mutated functions in chromosomal maintenance.
Hypersensitivity
ChAM, a novel motif that mediates PALB2 intrinsic chromatin binding and facilitates DNA repair.
Hypersensitivity
Collaborative action of Brca1 and CtIP in elimination of covalent modifications from double-strand breaks to facilitate subsequent break repair.
Hypersensitivity
Collaborative roles of gammaH2AX and the Rad51 paralog Xrcc3 in homologous recombinational repair.
Hypersensitivity
Deregulation of DNA double-strand break repair in multiple myeloma: implications for genome stability.
Hypersensitivity
Differential requirements for RAD51 in Physcomitrella patens and Arabidopsis thaliana development and DNA damage repair.
Hypersensitivity
Differential roles of XRCC2 in homologous recombinational repair of stalled replication forks.
Hypersensitivity
Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2.
Hypersensitivity
Expression of BRC repeats in breast cancer cells disrupts the BRCA2-Rad51 complex and leads to radiation hypersensitivity and loss of G(2)/M checkpoint control.
Hypersensitivity
Fanconi anemia pathway heterogeneity revealed by cisplatin and oxaliplatin treatments.
Hypersensitivity
Haploinsufficiency of RAD51B causes centrosome fragmentation and aneuploidy in human cells.
Hypersensitivity
Intrinsic ATR signaling shapes DNA end resection and suppresses toxic DNA-PKcs signaling.
Hypersensitivity
Large-scale generation and phenotypic characterization of zebrafish CRISPR mutants of DNA repair genes.
Hypersensitivity
Poly (ADP-Ribose) Polymerase Inhibitor Hypersensitivity in Aggressive Myeloproliferative Neoplasms.
Hypersensitivity
Recruitment of Rad51 and Rad52 to short telomeres triggers a Mec1-mediated hypersensitivity to double-stranded DNA breaks in senescent budding yeast.
Hypersensitivity
Synaptonemal complex protein SYCP3 impairs mitotic recombination by interfering with BRCA2.
Hypersensitivity
Yeast Bromodomain Factor 1 and Its Human Homolog TAF1 Play Conserved Roles in Promoting Homologous Recombination.
Hypertension
Bone morphogenetic protein signaling is required for RAD51-mediated maintenance of genome integrity in vascular endothelial cells.
Idiopathic Pulmonary Fibrosis
FoxM1-dependent RAD51 and BRCA2 signaling protects idiopathic pulmonary fibrosis fibroblasts from radiation-induced cell death.
Infections
Arabidopsis BRCA2 and RAD51 proteins are specifically involved in defense gene transcription during plant immune responses.
Infections
External Beam Radiation Therapy and Enadenotucirev: Inhibition of the DDR and Mechanisms of Radiation-Mediated Virus Increase.
Infections
Inhibition of autophagy aggravates DNA damage response and gastric tumorigenesis via Rad51 ubiquitination in response to H. pylori infection.
Infections
Lack of association of RAD51 genetic variations with hepatitis B virus clearance and occurrence of hepatocellular carcinoma in a Korean population.
Infections
Multiple DNA damage signaling and repair pathways deregulated by simian virus 40 large T antigen.
Infections
Protection elicited by a replication-defective adenovirus vector expressing the tick-borne encephalitis virus non-structural glycoprotein NS1.
Infections
RAD51 G135C genetic polymorphism and their potential role in gastric cancer induced by Helicobacter pylori infection in Bhutan.
Infections
The DNA damage response promotes polyomavirus JC infection by nucleus to cytoplasm NF- kappaB activation.
Infections
The in vivo and in vitro roles of Trypanosoma cruzi Rad51 in the repair of DNA double strand breaks and oxidative lesions.
Infertility
Differing requirements for RAD51 and DMC1 in meiotic pairing of centromeres and chromosome arms in Arabidopsis thaliana.
Infertility
Expression of Rad51 and the histo-morphological evaluation of testis of the sterile male cattle-yak.
Infertility
Functional analysis of the Drosophila Rad51 gene (spn-A) in repair of DNA damage and meiotic chromosome segregation.
Infertility
Meiotic Recombination in Arabidopsis Is Catalysed by DMC1, with RAD51 Playing a Supporting Role.
Infertility
Overexpression of MicroRNA-10a in Germ Cells Causes Male Infertility by Targeting Rad51 in Mouse and Human.
Infertility, Male
A meiosis-specific BRCA2 binding protein recruits recombinases to DNA double-strand breaks to ensure homologous recombination.
Infertility, Male
Overexpression of MicroRNA-10a in Germ Cells Causes Male Infertility by Targeting Rad51 in Mouse and Human.
Keratoconus
Polymorphisms of the homologous recombination gene RAD51 in keratoconus and Fuchs endothelial corneal dystrophy.
Keratoconus
Rare, potentially pathogenic variants in 21 keratoconus candidate genes are not enriched in cases in a large Australian cohort of European descent.
Laminopathies
Lamin A ?exon9 mutation leads to telomere and chromatin defects but not genomic instability.
Laryngeal Neoplasms
Polymorphism of the DNA repair genes RAD51 and XRCC2 in smoking- and drinking-related laryngeal cancer in a Polish population.
Laryngeal Neoplasms
[Expression of RAD51 in carcinomas of cancer of larynx and its clinical significance]
Leiomyoma
Familial occurrence of thymoma and autoimmune diseases with the constitutional translocation t(14;20)(q24.1;p12.3).
Leiomyoma
Integrated data analysis reveals uterine leiomyoma subtypes with distinct driver pathways and biomarkers.
Lentivirus Infections
[RAD51 promotes proliferation and migration of glioblastoma cells and decreases sensitivity of cells to temozolomide].
Leukemia
Association between RAD51 gene polymorphism (-135G/C) and susceptibility of myelodysplastic syndrome and acute leukemia: evidence based on a meta-analysis.
Leukemia
BLM helicase is activated in BCR/ABL leukemia cells to modulate responses to cisplatin.
Leukemia
Enhancing the efficacy of glycolytic blockade in cancer cells via RAD51 inhibition.
Leukemia
Genetic polymorphisms of RAD51, XRCC3 and acute myeloid leukemia risk: a meta-analysis.
Leukemia
MEN1 is a melanoma tumor suppressor that preserves genomic integrity by stimulating transcription of genes that promote homologous recombination-directed DNA repair.
Leukemia
ORCA/LRWD1 Regulates Homologous Recombination at ALT-Telomeres by Modulating Heterochromatin Organization.
Leukemia
Poly (ADP-Ribose) Polymerase Inhibitor Hypersensitivity in Aggressive Myeloproliferative Neoplasms.
Leukemia
Role of the NRP-1-mediated VEGFR2-independent pathway on radiation sensitivity of non-small cell lung cancer cells.
Leukemia
Synergism between etoposide and 17-AAG in leukemia cells: critical roles for Hsp90, FLT3, topoisomerase II, Chk1, and Rad51.
Leukemia
Targeting RAD51 enhances chemosensitivity of adult T?cell leukemia?lymphoma cells by reducing DNA double?strand break repair.
Leukemia
Targeting RAD51 phosphotyrosine-315 to prevent unfaithful recombination repair in BCR-ABL1 leukemia.
Leukemia, Lymphocytic, Chronic, B-Cell
Germline mutations in RAD51, RAD51AP1, RAD51B, RAD51C,RAD51D, RAD52 and RAD54L do not contribute to familial chronic lymphocytic leukemia.
Leukemia, Lymphocytic, Chronic, B-Cell
Pir51, a Rad51-interacting protein with high expression in aggressive lymphoma, controls mitomycin C sensitivity and prevents chromosomal breaks.
Leukemia, Lymphoid
Attenuating homologous recombination stimulates an AID-induced antileukemic effect.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Poly (ADP-Ribose) Polymerase Inhibitor Hypersensitivity in Aggressive Myeloproliferative Neoplasms.
Leukemia, Myeloid, Acute
135G/C polymorphism in the RAD51 gene and acute myeloid leukemia risk: a meta-analysis.
Leukemia, Myeloid, Acute
DNA repair polymorphisms and outcome of chemotherapy for acute myelogenous leukemia: a report from the Children's Oncology Group.
Leukemia, Myeloid, Acute
Genetic polymorphisms of RAD51, XRCC3 and acute myeloid leukemia risk: a meta-analysis.
Leukemia, Myeloid, Acute
HDAC Inhibition Induces MicroRNA-182, which Targets RAD51 and Impairs HR Repair to Sensitize Cells to Sapacitabine in Acute Myelogenous Leukemia.
Leukemia, Myeloid, Acute
Histone deacetylases 1 and 2 cooperate in regulating BRCA1, CHK1, and RAD51 expression in acute myeloid leukemia cells.
Leukemia, Myeloid, Acute
Homologous recombination as a resistance mechanism to replication-induced double-strand breaks caused by the antileukemia agent CNDAC.
Leukemia, Myeloid, Acute
MicroRNA-107 promotes apoptosis of acute myelocytic leukemia cells by targeting RAD51.
Leukemia, Myeloid, Acute
Polymorphisms in human homeobox HLX1 and DNA repair RAD51 genes increase the risk of therapy-related acute myeloid leukemia.
Leukemia, Myeloid, Acute
RAD51 and XRCC3 Gene Polymorphisms and the Risk of Developing Acute Myeloid Leukemia.
Leukemia, Myeloid, Acute
RAD51 and XRCC3 polymorphisms: Impact on the risk and treatment outcomes of de novo inv(16) or t(16;16)/CBF?-MYH11(+) acute myeloid leukemia.
Leukemia, Myeloid, Acute
Suberoylanilide hydroxamic acid induces hypersensitivity to radiation therapy in acute myelogenous leukemia cells expressing constitutively active FLT3 mutants.
Leukemia, Myelomonocytic, Chronic
Poly (ADP-Ribose) Polymerase Inhibitor Hypersensitivity in Aggressive Myeloproliferative Neoplasms.
Leukemia-Lymphoma, Adult T-Cell
Assessment of HTLV-1 proviral load, LAT, BIM, c-FOS and RAD51 gene expression in adult T cell leukemia/lymphoma.
Liver Neoplasms
Identification of Rad51 as a prognostic biomarker correlated with immune infiltration in hepatocellular carcinoma.
Lung Neoplasms
(-)-Guaiol regulates RAD51 stability via autophagy to induce cell apoptosis in non-small cell lung cancer.
Lung Neoplasms
Astaxanthin down-regulates Rad51 expression via inactivation of AKT kinase to enhance mitomycin C-induced cytotoxicity in human non-small cell lung cancer cells.
Lung Neoplasms
ATR-p53 Restricts Homologous Recombination in Response to Replicative Stress but Does Not Limit DNA Interstrand Crosslink Repair in Lung Cancer Cells.
Lung Neoplasms
Combined evaluation of Rad51 and ERCC1 expressions for sensitivity to platinum agents in non-small cell lung cancer.
Lung Neoplasms
Combining carbon ion irradiation and non-homologous end-joining repair inhibitor NU7026 efficiently kills cancer cells.
Lung Neoplasms
Curcumin enhances the mitomycin C-induced cytotoxicity via downregulation of MKK1/2-ERK1/2-mediated Rad51 expression in non-small cell lung cancer cells.
Lung Neoplasms
DNA repair and cytotoxic drugs: the potential role of RAD51 in clinical outcome of non-small-cell lung cancer patients.
Lung Neoplasms
DNA replication stress response involving PLK1, CDC6, POLQ, RAD51 and CLASPIN upregulation prognoses the outcome of early/mid-stage non-small cell lung cancer patients.
Lung Neoplasms
Downregulation of Rad51 expression overcomes drug resistance to gemcitabine in human non-small cell lung cancer cells.
Lung Neoplasms
Effects of emodin extracted from Chinese herbs on proliferation of non-small cell lung cancer and underlying mechanisms.
Lung Neoplasms
ER stress suppresses DNA double-strand break repair and sensitizes tumor cells to ionizing radiation by stimulating proteasomal degradation of Rad51.
Lung Neoplasms
High expression of RAD51 promotes DNA damage repair and survival in KRAS-mutant lung cancer cells.
Lung Neoplasms
High-level expression of Rad51 is an independent prognostic marker of survival in non-small-cell lung cancer patients.
Lung Neoplasms
HSP90 inhibition induces cytotoxicity via down-regulation of Rad51 expression and DNA repair capacity in non-small cell lung cancer cells.
Lung Neoplasms
Identification of cancer biomarkers of prognostic value using specific gene regulatory networks (GRN): a novel role of RAD51AP1 for ovarian and lung cancers.
Lung Neoplasms
Induction of Rad51 protein levels by p38 MAPK decreases cytotoxicity and mutagenicity in benzo[a]pyrene-exposed human lung cancer cells.
Lung Neoplasms
Influence of DNA repair RAD51 gene variants in overall survival of non-small cell lung cancer patients treated with first line chemotherapy.
Lung Neoplasms
Involvement of Rad51 in cytotoxicity induced by epidermal growth factor receptor inhibitor (gefitinib, IressaR) and chemotherapeutic agents in human lung cancer cells.
Lung Neoplasms
Major pathologic response and RAD51 predict survival in lung cancer patients receiving neoadjuvant chemotherapy.
Lung Neoplasms
Minocycline enhances mitomycin C-induced cytotoxicity through down-regulating ERK1/2-mediated Rad51 expression in human non-small cell lung cancer cells.
Lung Neoplasms
Modulation of Rad51, ERCC1, and thymidine phosphorylase by emodin result in synergistic cytotoxic effect in combination with capecitabine.
Lung Neoplasms
Prognostic and predictive value of loss of nuclear RAD51 immunoreactivity in resected non-small cell lung cancer patients.
Lung Neoplasms
Rad51 in regulating the radiosensitivity of non-small cell lung cancer with different epidermal growth factor receptor mutation status.
Lung Neoplasms
Role of Rad51 down-regulation and extracellular signal-regulated kinases 1 and 2 inactivation in emodin and mitomycin C-induced synergistic cytotoxicity in human non-small-cell lung cancer cells.
Lung Neoplasms
Role of repair protein Rad51 in regulating the response to gefitinib in human non-small cell lung cancer cells.
Lung Neoplasms
Roles of MKK1/2-ERK1/2 and phosphoinositide 3-kinase-AKT signaling pathways in erlotinib-induced Rad51 suppression and cytotoxicity in human non-small cell lung cancer cells.
Lung Neoplasms
Suppression of ERCC1 and Rad51 expression through ERK1/2 inactivation is essential in emodin-mediated cytotoxicity in human non-small cell lung cancer cells.
Lung Neoplasms
The impact of functional LIG4 polymorphism on platinum-based chemotherapy response and survival in non-small cell lung cancer.
Lung Neoplasms
The role of celecoxib in Rad51 expression and cell survival affected by gefitinib in human non-small cell lung cancer cells.
Lung Neoplasms
The role of repair protein Rad51 in synergistic cytotoxicity and mutagenicity induced by epidermal growth factor receptor inhibitor (Gefitinib, IressaR) and benzo[a]pyrene in human lung cancer.
Lymphatic Metastasis
Alpinumisoflavone causes DNA damage in Colorectal Cancer Cells via blocking DNA repair mediated by RAD51.
Lymphatic Metastasis
DNA Repair Protein Rad51 Induces Tumor Growth and Metastasis in Esophageal Squamous Cell Carcinoma via a p38/Akt-Dependent Pathway.
Lymphatic Metastasis
Expression of PH Domain Leucine-rich Repeat Protein Phosphatase, Forkhead Homeobox Type O 3a and RAD51, and their Relationships with Clinicopathologic Features and Prognosis in Ovarian Serous Adenocarcinoma.
Lymphatic Metastasis
Expression of RAD51 and Its Clinical Impact in Oral Squamous Cell Carcinoma.
Lymphatic Metastasis
Increased Expression of BRCA2 and RAD51 in Lymph Node Metastases of Canine Mammary Adenocarcinomas.
Lymphatic Metastasis
Overexpression of Rad51 Predicts Poor Prognosis in Colorectal Cancer: Our Experience with 54 Patients.
Lymphatic Metastasis
Upregulation of RAD51 expression is associated with progression of thyroid carcinoma.
Lymphatic Metastasis
[Expression of RAD51 in carcinomas of cancer of larynx and its clinical significance]
Lymphoma
Pir51, a Rad51-interacting protein with high expression in aggressive lymphoma, controls mitomycin C sensitivity and prevents chromosomal breaks.
Lymphoma, B-Cell
Ablation of XRCC2/3 transforms immunoglobulin V gene conversion into somatic hypermutation.
Lymphoma, Follicular
MicroRNA profiling of follicular lymphoma identifies microRNAs related to cell proliferation and tumor response.
Lymphoma, Mantle-Cell
Pir51, a Rad51-interacting protein with high expression in aggressive lymphoma, controls mitomycin C sensitivity and prevents chromosomal breaks.
Macular Degeneration
Adherence to a Mediterranean diet, genetic susceptibility, and progression to advanced macular degeneration: a prospective cohort study.
Macular Degeneration
Dietary folate, B vitamins, genetic susceptibility and progression to advanced nonexudative age-related macular degeneration with geographic atrophy: a prospective cohort study.
Macular Degeneration
RAD51 gene is associated with advanced age-related macular degeneration in Chinese population.
Malaria
Synergistic Action between PfHsp90 Inhibitor and PfRad51 Inhibitor Induces Elevated DNA Damage Sensitivity in the Malaria Parasite.
Medulloblastoma
Estrogen receptor beta-mediated nuclear interaction between IRS-1 and Rad51 inhibits homologous recombination directed DNA repair in medulloblastoma.
Medulloblastoma
Inhibition of ER? induces resistance to cisplatin by enhancing Rad51-mediated DNA repair in human medulloblastoma cell lines.
Melanoma
Distinct genomic traits of acral and mucosal melanomas revealed by targeted mutational profiling.
Melanoma
Enhanced Histone Deacetylase Activity in Malignant Melanoma Provokes RAD51 and FANCD2-Triggered Drug Resistance.
Melanoma
Melanoma cells replicate through chemotherapy by reducing levels of key homologous recombination protein RAD51 and increasing expression of translesion synthesis DNA polymerase ?.
Melanoma
Reduced FANCD2 influences spontaneous SCE and RAD51 foci formation in uveal melanoma and Fanconi anaemia.
Melanoma
Targeting Rad51 as a strategy for the treatment of melanoma cells resistant to MAPK pathway inhibition.
Melanoma
The combination of chemotherapy with HVJ-E containing Rad51 siRNA elicited diverse anti-tumor effects and synergistically suppressed melanoma.
Mesothelioma
Evaluation of gene expression levels in the diagnosis of lung adenocarcinoma and malignant pleural mesothelioma.
Mesothelioma, Malignant
Evaluation of gene expression levels in the diagnosis of lung adenocarcinoma and malignant pleural mesothelioma.
Movement Disorders
Abnormal subcortical activity in congenital mirror movement disorder with RAD51 mutation.
Movement Disorders
Selective chromatid segregation mechanism invoked for the human congenital mirror hand movement disorder development by RAD51 mutations: a hypothesis.
Multiple Myeloma
A peptide nucleic acid targeting nuclear RAD51 sensitizes multiple myeloma cells to melphalan treatment.
Multiple Myeloma
A Small-Molecule Inhibitor of RAD51 Reduces Homologous Recombination and Sensitizes Multiple Myeloma Cells to Doxorubicin.
Multiple Myeloma
Suberoylanilide Hydroxamic Acid as a Radiosensitizer through Modulation of RAD51 Protein and Inhibition of Homology-Directed Repair in Multiple Myeloma.
Myelodysplastic Syndromes
Association between RAD51 gene polymorphism (-135G/C) and susceptibility of myelodysplastic syndrome and acute leukemia: evidence based on a meta-analysis.
Myelodysplastic Syndromes
Can synthetic lethality approach be used with DNA repair genes for primary and secondary MDS?
Myelodysplastic Syndromes
RAD51 and XRCC3 polymorphism frequency and risk of myelodysplastic syndromes.
Nasopharyngeal Carcinoma
Inhibition of autophagy enhances the radiosensitivity of nasopharyngeal carcinoma by reducing Rad51 expression.
Nasopharyngeal Carcinoma
Rad51 Expression in Nasopharyngeal Carcinoma and Its Association with Tumor Reduction: A Preliminary Study in Indonesia.
Nasopharyngeal Neoplasms
RPA1 downregulation enhances nasopharyngeal cancer radiosensitivity via blocking RAD51 to the DNA damage site.
Neoplasm Metastasis
Alpinumisoflavone causes DNA damage in Colorectal Cancer Cells via blocking DNA repair mediated by RAD51.
Neoplasm Metastasis
DNA Repair Protein Rad51 Induces Tumor Growth and Metastasis in Esophageal Squamous Cell Carcinoma via a p38/Akt-Dependent Pathway.
Neoplasm Metastasis
Expression of PH Domain Leucine-rich Repeat Protein Phosphatase, Forkhead Homeobox Type O 3a and RAD51, and their Relationships with Clinicopathologic Features and Prognosis in Ovarian Serous Adenocarcinoma.
Neoplasm Metastasis
Gene Prioritization through Consensus Strategy, Enrichment Methodologies Analysis, and Networking for Osteosarcoma Pathogenesis.
Neoplasm Metastasis
High RAD51 mRNA expression characterize estrogen receptor-positive/progesteron receptor-negative breast cancer and is associated with patient's outcome.
Neoplasm Metastasis
Identification of hub genes associated with esophageal cancer progression using bioinformatics analysis.
Neoplasm Metastasis
Increased Expression of BRCA2 and RAD51 in Lymph Node Metastases of Canine Mammary Adenocarcinomas.
Neoplasm Metastasis
Overexpression of Rad51 Predicts Poor Prognosis in Colorectal Cancer: Our Experience with 54 Patients.
Neoplasm Metastasis
Positive effect of single nucleotide RAD51 135G>C polymorphism and low Ku70 protein expression on female rectal cancer patients survival after preoperative radiotherapy.
Neoplasm Metastasis
The level of secretory leukocyte protease inhibitor is decreased in metastatic head and neck squamous cell carcinoma.
Neoplasm Metastasis
Upregulation of RAD51 expression is associated with progression of thyroid carcinoma.
Neoplasm Metastasis
[Expression of RAD51 in carcinomas of cancer of larynx and its clinical significance]
Neoplasms
135G>C and 172G>T polymorphism in the 5' untranslated region of RAD51 and sporadic endometrial cancer risk in Polish women.
Neoplasms
172G>T variant in the 5' untranslated region of DNA repair gene RAD51 reduces risk of squamous cell carcinoma of the head and neck and interacts with a P53 codon 72 variant.
Neoplasms
?1-integrin impacts Rad51 stability and DNA double-strand break repair by homologous recombination.
Neoplasms
A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage.
Neoplasms
A function for cyclin D1 in DNA repair uncovered by protein interactome analyses in human cancers.
Neoplasms
A high-throughput chemical screen with FDA approved drugs reveals that the antihypertensive drug Spironolactone impairs cancer cell survival by inhibiting homology directed repair.
Neoplasms
A Lamin-Binding Ligand Inhibits Homologous Recombination Repair of DNA Double-Strand Breaks.
Neoplasms
A marker of homologous recombination predicts pathological complete response to neoadjuvant chemotherapy in primary breast cancer.
Neoplasms
A molecular 'signature' of primary breast cancer cultures; patterns resembling tumor tissue.
Neoplasms
A multiplexed bioluminescent reporter for sensitive and non-invasive tracking of DNA double strand break repair dynamics in vitro and in vivo.
Neoplasms
A novel small molecule RAD51 inactivator overcomes imatinib-resistance in chronic myeloid leukaemia.
Neoplasms
A panel of tumor biomarkers to predict complete pathological response to neo-adjuvant treatment in Locally Advanced Rectal Cancer.
Neoplasms
A peptide nucleic acid targeting nuclear RAD51 sensitizes multiple myeloma cells to melphalan treatment.
Neoplasms
A RAD51 assay feasible in routine tumor samples calls PARP inhibitor response beyond BRCA mutation.
Neoplasms
A Short BRCA2-Derived Cell-Penetrating Peptide Targets RAD51 Function and Confers Hypersensitivity toward PARP Inhibition.
Neoplasms
A single nucleotide polymorphism in the 5' untranslated region of RAD51 and risk of cancer among BRCA1/2 mutation carriers.
Neoplasms
A single nucleotide polymorphism in the RAD51 gene modifies cancer risk in BRCA2 but not BRCA1 carriers.
Neoplasms
A small molecule inhibitor of human RAD51 potentiates breast cancer cell killing by therapeutic agents in mouse xenografts.
Neoplasms
A small-molecule inhibitor of the BRCA2-RAD51 interaction modulates RAD51 assembly and potentiates DNA damage-induced cell death.
Neoplasms
A specific RAD51 haplotype increases breast cancer risk in Jewish non-Ashkenazi high-risk women.
Neoplasms
A tumour-derived mutant allele of XRCC2 preferentially suppresses homologous recombination at DNA replication forks.
Neoplasms
A variant of the breast cancer type 2 susceptibility protein (BRC) repeat is essential for the RECQL5 helicase to interact with RAD51 recombinase for genome stabilization.
Neoplasms
Accurate quantification of homologous recombination in zebrafish: brca2 deficiency as a paradigm.
Neoplasms
Adenoviral vector driven by a minimal Rad51 promoter is selective for p53-deficient tumor cells.
Neoplasms
AKT1 inhibits homologous recombination by inducing cytoplasmic retention of BRCA1 and RAD51.
Neoplasms
Alternative transcript imbalance underlying breast cancer susceptibility in a family carrying PALB2 c.3201+5G>T.
Neoplasms
An optimized RAD51 inhibitor that disrupts homologous recombination without requiring Michael acceptor reactivity.
Neoplasms
Analysis of 11 candidate genes in 849 adult patients with suspected hereditary cancer predisposition.
Neoplasms
Analysis of DNA Damage Response Gene Alterations and Tumor Mutational Burden Across 17,486 Tubular Gastrointestinal Carcinomas: Implications for Therapy.
Neoplasms
ARLTS1, MDM2 and RAD51 gene variations are associated with familial breast cancer.
Neoplasms
Arsenic Trioxide exerts cytotoxic and radiosensitizing effects in pediatric Medulloblastoma cell lines of SHH Subgroup.
Neoplasms
Assessment of DNA Repair Gene Expressions in Vitrified Mouse Preantral Follicles.
Neoplasms
Association between a functional variant in RAD51 gene's 3' untranslated region and its mRNA expression in lymphoblastoid cell lines.
Neoplasms
Association between polymorphisms of the DNA repair gene RAD51 and ovarian cancer.
Neoplasms
Association between RAD51 135 G/C polymorphism and risk of 3 common gynecological cancers: A meta-analysis.
Neoplasms
Association between the RAD51 135 G>C Polymorphism and Risk of Cancer: A Meta-Analysis of 19,068 Cases and 22,630 Controls.
Neoplasms
Association of RAD51 with Homologous Recombination Deficiency (HRD) and clinical outcomes in untreated triple-negative breast cancer (TNBC): analysis of the GeparSixto randomized clinical trial.
Neoplasms
ATP hydrolysis by mammalian RAD51 has a key role during homology-directed DNA repair.
Neoplasms
ATR inhibition preferentially targets homologous recombination-deficient tumor cells.
Neoplasms
Aurora-A expressing tumour cells are deficient for homology-directed DNA double strand-break repair and sensitive to PARP inhibition.
Neoplasms
Autoantibodies in sera of pancreatic cancer patients identify recombination factor Rad51 as a tumour-associated antigen.
Neoplasms
BARD1 homozygous deletion, a possible alternative to BRCA1 mutation in basal breast cancer.
Neoplasms
Biomarkers Associating with PARP Inhibitor Benefit in Prostate Cancer in the TOPARP-B Trial.
Neoplasms
BRCA1 and BRCA2 heterozygosity in embryonic stem cells reduces radiation-induced Rad51 focus formation but is not associated with radiosensitivity.
Neoplasms
BRCA1 Mutation-Specific Responses to 53BP1 Loss-Induced Homologous Recombination and PARP Inhibitor Resistance.
Neoplasms
BRCA1 Protein Expression Predicts Survival in Glioblastoma Patients from an NRG Oncology RTOG Cohort.
Neoplasms
BRCA2 coordinates the activities of cell-cycle kinases to promote genome stability.
Neoplasms
BRCA2 is required for ionizing radiation-induced assembly of Rad51 complex in vivo.
Neoplasms
c-Myc Sustains Transformed Phenotype and Promotes Radioresistance of Embryonal Rhabdomyosarcoma Cell Lines.
Neoplasms
Canine mammary tumor risk is associated with polymorphisms in RAD51 and STK11 genes.
Neoplasms
CD81 Enhances Radioresistance of Glioblastoma by Promoting Nuclear Translocation of Rad51.
Neoplasms
CDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repair.
Neoplasms
CDKN3 promotes tumor progression and confers cisplatin resistance via RAD51 in esophageal cancer.
Neoplasms
Characterization of Gastric Cardia Tumors: Differences in Helicobacter pylori Strains and Genetic Polymorphisms.
Neoplasms
Characterization of the human Rad51 genomic locus and examination of tumors with 15q14-15 loss of heterozygosity (LOH).
Neoplasms
CHD4 regulates platinum sensitivity through MDR1 expression in ovarian cancer: A potential role of CHD4 inhibition as a combination therapy with platinum agents.
Neoplasms
Cisplatin in Combination with MDM2 Inhibition Downregulates Rad51 Recombinase in a Bimodal Manner to Inhibit Homologous Recombination and Augment Tumor Cell Kill.
Neoplasms
Clinical Activity and Safety of Cediranib and Olaparib Combination in Patients with Metastatic Pancreatic Ductal Adenocarcinoma without BRCA Mutation.
Neoplasms
Clinicopathological and Prognostic Characteristics of RAD51 in Colorectal Cancer.
Neoplasms
Clinicopathological and prognostic significance of RECQL5 helicase expression in breast cancers.
Neoplasms
Clinicopathological significance of KU70/KU80, a key DNA damage repair protein in breast cancer.
Neoplasms
Combined Inhibition of Rad51 and Wee1 Enhances Cell Killing in HNSCC Through Induction of Apoptosis Associated With Excessive DNA Damage and Replication Stress.
Neoplasms
Common cancer-associated imbalances in the DNA damage response confer sensitivity to single agent ATR inhibition.
Neoplasms
Common gene variants in RAD51, XRCC2 and XPD are not associated with clinical outcome in soft-tissue sarcoma patients.
Neoplasms
Common germline haplotypes and genotypes identified in BRCA2 exon 11 of dogs with Mammary Tumors and histopathological analyses.
Neoplasms
CtBP1 transactivates RAD51 and confers cisplatin resistance to breast cancer cells.
Neoplasms
Curcumin enhances the mitomycin C-induced cytotoxicity via downregulation of MKK1/2-ERK1/2-mediated Rad51 expression in non-small cell lung cancer cells.
Neoplasms
Cyclic hypoxia does not alter RAD51 expression or PARP inhibitor cell kill in tumor cells.
Neoplasms
DAXX, as a Tumor Suppressor, Impacts DNA Damage Repair and Sensitizes BRCA-Proficient TNBC Cells to PARP Inhibitors.
Neoplasms
Defects in homologous recombination repair in mismatch-repair-deficient tumour cell lines.
Neoplasms
Defects in recombination activity caused by somatic and germline mutations in the multimerization/BRCA2 binding region of human RAD51 protein.
Neoplasms
Delayed DNA double-strand break repair following platin-based chemotherapy predicts treatment response in head and neck squamous cell carcinoma.
Neoplasms
Design of BRC analogous peptides based on the complex BRC8-RAD51 and the preliminary study on the peptide structures.
Neoplasms
Design of potent inhibitors of human RAD51 recombinase based on BRC motifs of BRCA2 protein: modeling and experimental validation of a chimera peptide.
Neoplasms
Design, synthesis and interaction of BRC4 analogous peptides with RAD51(241-260).
Neoplasms
Detection of loss of heterozygosity at RAD51, RAD52, RAD54 and BRCA1 and BRCA2 loci in breast cancer: pathological correlations.
Neoplasms
Development of a functional assay for homologous recombination status in primary cultures of epithelial ovarian tumor and correlation with sensitivity to poly(ADP-ribose) polymerase inhibitors.
Neoplasms
DIDS, a chemical compound that inhibits RAD51-mediated homologous pairing and strand exchange.
Neoplasms
Differential regulation of DNA repair protein Rad51 in human tumour cell lines exposed to doxorubicin.
Neoplasms
Differential Requirements for the RAD51 Paralogs in Genome Repair and Maintenance in Human Cells.
Neoplasms
Disparate Impact of Butyroyloxymethyl Diethylphosphate (AN-7), a Histone Deacetylase Inhibitor, and Doxorubicin in Mice Bearing a Mammary Tumor.
Neoplasms
Dissecting the Recombination Mediator Activity of BRCA2 Using Biochemical Methods.
Neoplasms
DNA damage response markers are differentially expressed in BRCA-mutated breast cancers.
Neoplasms
DNA double-strand break repair signalling: the case of RAD51 post-translational regulation.
Neoplasms
DNA repair gene polymorphisms and susceptibility to familial breast cancer in a group of patients from Campinas, Brazil.
Neoplasms
DNA repair genes in astrocytoma tumorigenesis, progression and therapy resistance.
Neoplasms
DNA Repair Protein Rad51 Induces Tumor Growth and Metastasis in Esophageal Squamous Cell Carcinoma via a p38/Akt-Dependent Pathway.
Neoplasms
DNA-damage related genes and clinical outcome in hormone receptor positive breast cancer.
Neoplasms
Down-regulation of Rad51 and decreased homologous recombination in hypoxic cancer cells.
Neoplasms
Downregulation of DNA repair proteins and increased DNA damage in hypoxic colon cancer cells is a therapeutically exploitable vulnerability.
Neoplasms
Effect of the BRCA2 CTRD domain on RAD51 filaments analyzed by an ensemble of single molecule techniques.
Neoplasms
Effects of HsRad51 overexpression on cell proliferation, cell cycle progression, and apoptosis.
Neoplasms
EGFR-Inhibition Enhances Apoptosis in Irradiated Human Head and Neck Xenograft Tumors Independent of Effects on DNA Repair.
Neoplasms
Elevated expression of Rad51 is correlated with decreased survival in resectable esophageal squamous cell carcinoma.
Neoplasms
Emodin enhances gefitinib-induced cytotoxicity via Rad51 downregulation and ERK1/2 inactivation.
Neoplasms
Engineering Archeal Surrogate Systems for the Development of Protein-Protein Interaction Inhibitors against Human RAD51.
Neoplasms
Enhancing survival of mouse oocytes following chemotherapy or aging by targeting Bax and Rad51.
Neoplasms
Enhancing the efficacy of glycolytic blockade in cancer cells via RAD51 inhibition.
Neoplasms
Epidermal growth factor receptor mutation status and rad51 determine the response of glioblastoma to multimodality therapy with cetuximab, temozolomide, and radiation.
Neoplasms
Epigenetic therapy using the histone deacetylase inhibitor for increasing therapeutic gain in oral cancer: Prevention of radiation-induced oral mucositis and inhibition of chemical-induced oral carcinogenesis.
Neoplasms
Epigenomic Analysis of RAD51 ChIP-seq Data Reveals cis-regulatory Elements Associated with Autophagy in Cancer Cell Lines.
Neoplasms
ER stress suppresses DNA double-strand break repair and sensitizes tumor cells to ionizing radiation by stimulating proteasomal degradation of Rad51.
Neoplasms
Evolution, structure and emerging roles of C1ORF112 in DNA replication, DNA damage responses, and cancer.
Neoplasms
Expression of DNA Damage Response Proteins and Associations with Clinicopathologic Characteristics in Chinese Familial Breast Cancer Patients with BRCA1/2 Mutations.
Neoplasms
Expression of PH Domain Leucine-rich Repeat Protein Phosphatase, Forkhead Homeobox Type O 3a and RAD51, and their Relationships with Clinicopathologic Features and Prognosis in Ovarian Serous Adenocarcinoma.
Neoplasms
Familial occurrence of thymoma and autoimmune diseases with the constitutional translocation t(14;20)(q24.1;p12.3).
Neoplasms
Fanconi anemia complementation group D2 (FANCD2) functions independently of BRCA2- and RAD51-associated homologous recombination in response to DNA damage.
Neoplasms
FIGNL1-containing protein complex is required for efficient homologous recombination repair.
Neoplasms
FoxM1 Inhibition Sensitizes Resistant Glioblastoma Cells to Temozolomide by Downregulating the Expression of DNA Repair Gene Rad51.
Neoplasms
Frequent Homologous Recombination Deficiency in High-grade Endometrial Carcinomas.
Neoplasms
Functional characterization of RebL1 highlights the evolutionary conservation of oncogenic activities of the RBBP4/7 orthologue in Tetrahymena thermophila.
Neoplasms
Functional Interaction Between BRCA1 and DNA Repair in Yeast May Uncover a Role of RAD50, RAD51, MRE11A, and MSH6 Somatic Variants in Cancer Development.
Neoplasms
Gene expression in tumor-adjacent normal tissue is associated with recurrence in patients with rectal cancer treated with adjuvant chemoradiation.
Neoplasms
Genetic 135G/C polymorphism of RAD51 gene and risk of cancer: a meta-analysis of 28,956 cases and 28,372 controls.
Neoplasms
Genetic Polymorphisms in the RAD51 Gene with a Risk of Head and Neck Cancer and Esophageal Cancer: A Meta-Analysis.
Neoplasms
Genetic variants of BLM interact with RAD51 to increase breast cancer susceptibility.
Neoplasms
Genome-wide search for loss of heterozygosity using laser capture microdissected tissue of breast carcinoma: an implication for mutator phenotype and breast cancer pathogenesis.
Neoplasms
Genomic copy number variation associated with clinical outcome in canine cutaneous mast cell tumors.
Neoplasms
Germline mutations in breast and ovarian cancer pedigrees establish RAD51C as a human cancer susceptibility gene.
Neoplasms
Gleevec-mediated inhibition of Rad51 expression and enhancement of tumor cell radiosensitivity.
Neoplasms
Glu-108 in Saccharomyces cerevisiae Rad51 Is Critical for DNA Damage-Induced Nuclear Function.
Neoplasms
Halenaquinone, a chemical compound that specifically inhibits the secondary DNA binding of RAD51.
Neoplasms
Haplotype and linkage disequilibrium architecture for human cancer-associated genes.
Neoplasms
High expression of RAD51 promotes DNA damage repair and survival in KRAS-mutant lung cancer cells.
Neoplasms
High levels of RAD51 perturb DNA replication elongation and cause unscheduled origin firing due to impaired CHK1 activation.
Neoplasms
High RAD51 mRNA expression characterize estrogen receptor-positive/progesteron receptor-negative breast cancer and is associated with patient's outcome.
Neoplasms
High-level expression of Rad51 is an independent prognostic marker of survival in non-small-cell lung cancer patients.
Neoplasms
High-resolution deletion mapping of 15q13.2-q21.1 in transitional cell carcinoma of the bladder.
Neoplasms
High-resolution genome-wide mapping of genetic alterations in human glial brain tumors.
Neoplasms
Histological groups of human postpubertal testicular germ cell tumours harbour different genetic alterations.
Neoplasms
Homologous recombination and cell cycle checkpoints: Rad51 in tumour progression and therapy resistance.
Neoplasms
Homologous recombination and human health: the roles of BRCA1, BRCA2, and associated proteins.
Neoplasms
Homologous Recombination Deficiency: Cancer Predispositions and Treatment Implications.
Neoplasms
Homologous recombination DNA repair deficiency and PARP inhibition activity in primary triple negative breast cancer.
Neoplasms
Homologous recombination preferentially repairs heat-induced DNA double-strand breaks in mammalian cells.
Neoplasms
Homozygous T172T and Heterozygous G135C Variants of Homologous Recombination Repairing Protein RAD51 are Related to Sporadic Breast Cancer Susceptibility.
Neoplasms
Hypermethylation of RAD51L3 and XRCC2 genes to predict late toxicity in chemoradiotherapy-treated cervical cancer patients.
Neoplasms
Hypoxia Potentiates the Radiation-Sensitizing Effect of Olaparib in Human Non-Small Cell Lung Cancer Xenografts by Contextual Synthetic Lethality.
Neoplasms
Identification and characterization of human Rad51 inhibitors by screening of an existing drug library.
Neoplasms
Identification of differentially expressed genes in pancreatic cancer cells using cDNA microarray.
Neoplasms
Identification of DNA Repair Pathways that Affect the Survival of Ovarian Cancer Cells Treated with a PARP Inhibitor in a Novel Drug Combination.
Neoplasms
Identification of Rad51 as a prognostic biomarker correlated with immune infiltration in hepatocellular carcinoma.
Neoplasms
Immunohistochemical expression of DNA repair proteins in familial breast cancer differentiate BRCA2-associated tumors.
Neoplasms
Impact of RAD51C-mediated Homologous Recombination on Genomic Integrity in Barrett's Adenocarcinoma Cells.
Neoplasms
In vitro evidence for homologous recombinational repair in resistance to melphalan.
Neoplasms
In Vivo Delivery of miR-34a Sensitizes Lung Tumors to Radiation Through RAD51 Regulation.
Neoplasms
In vivo profiling of hypoxic gene expression in gliomas using the hypoxia marker EF5 and laser-capture microdissection.
Neoplasms
Increased Expression of BRCA2 and RAD51 in Lymph Node Metastases of Canine Mammary Adenocarcinomas.
Neoplasms
Induction of p53 Phosphorylation at Serine 20 by Resveratrol Is Required to Activate p53 Target Genes, Restoring Apoptosis in MCF-7 Cells Resistant to Cisplatin.
Neoplasms
Induction of Rad51 protein levels by p38 MAPK decreases cytotoxicity and mutagenicity in benzo[a]pyrene-exposed human lung cancer cells.
Neoplasms
Inhibition of AKT-Signaling Sensitizes Soft Tissue Sarcomas (STS) and Gastrointestinal Stromal Tumors (GIST) to Doxorubicin via Targeting of Homology-Mediated DNA Repair.
Neoplasms
Inhibition of filament formation of human Rad51 protein by a small peptide derived from the BRC-motif of the BRCA2 protein.
Neoplasms
Inhibition of homologous recombination by treatment with BVDU (brivudin) or by RAD51 silencing increases chromosomal damage induced by bleomycin in mismatch repair-deficient tumour cells.
Neoplasms
Inhibition of homologous recombination in human cells by targeting RAD51 recombinase.
Neoplasms
Inhibition of RAD51 by siRNA and Resveratrol Sensitizes Cancer Stem Cells Derived from HeLa Cell Cultures to Apoptosis.
Neoplasms
Inhibition of the DSB repair protein RAD51 potentiates the cytotoxic efficacy of doxorubicin via promoting apoptosis-related death pathways.
Neoplasms
Interaction between RAD51 and MCM Complex Is Essential for RAD51 Foci Forming in Colon Cancer HCT116 Cells.
Neoplasms
Interactions between BRCA2 and RAD51 for promoting homologous recombination in Leishmania infantum.
Neoplasms
Interactions between canine RAD51 and full length or truncated BRCA2 BRC repeats.
Neoplasms
Interactions of the Rad51 inhibitor DIDS with human and bovine serum albumins: Optical spectroscopy and isothermal calorimetry approaches.
Neoplasms
Interplay between Fanconi anemia and homologous recombination pathways in genome integrity.
Neoplasms
Kinesin Family Member C1 Increases Temozolomide Resistance of Glioblastoma Through Promoting DNA Damage Repair.
Neoplasms
Knockdown of Rad51 expression induces radiation- and chemo-sensitivity in osteosarcoma cells.
Neoplasms
Late p65 nuclear translocation in glioblastoma cells indicates non-canonical TLR4 signaling and activation of DNA repair genes.
Neoplasms
Long time persistence of residual 53BP1/?-H2AX foci in human lymphocytes in relationship to apoptosis, chromatin condensation and biological dosimetry.
Neoplasms
Loss of heterozygosity for chromosomal regions 15q14-21.1, 17q21.31, and 13q12.3-13.1 and its relevance for prostate cancer.
Neoplasms
Loss of Rad51c leads to embryonic lethality and modulation of Trp53-dependent tumorigenesis in mice.
Neoplasms
Low levels of circulating estrogen sensitize PTEN-null endometrial tumors to PARP inhibition in vivo.
Neoplasms
Mechanisms of genome maintenance and rearrangement: current research and recent advances in DNA repair and recombination.
Neoplasms
Methotrexate-mediated inhibition of RAD51 expression and homologous recombination in cancer cells.
Neoplasms
miR-155 Over-expression Promotes Genomic Instability by Reducing High-fidelity Polymerase Delta Expression and Activating Error-prone DSB Repair.
Neoplasms
MiR-509-3 augments the synthetic lethality of PARPi by regulating HR repair in PDX model of HGSOC.
Neoplasms
MiR-96 Downregulates REV1 and RAD51 to Promote Cellular Sensitivity to Cisplatin and PARP Inhibition.
Neoplasms
Molecular pathways: understanding the role of Rad52 in homologous recombination for therapeutic advancement.
Neoplasms
Network Analysis of RAD51 Proteins in Metazoa and the Evolutionary Relationships With Their Archaeal Homologs.
Neoplasms
Neutrophils Alter DNA Repair Landscape to Impact Survival and Shape Distinct Therapeutic Phenotypes of Colorectal Cancer.
Neoplasms
Nonsense mutation at codon 63 of the BRCA1 gene in Japanese breast cancer patients.
Neoplasms
Normal expression of DNA repair proteins, hMre11, Rad50 and Rad51 but protracted formation of Rad50 containing foci in X-irradiated skin fibroblasts from radiosensitive cancer patients.
Neoplasms
O6-methylguanine-DNA methyltransferase modulates cisplatin-induced DNA double-strand breaks by targeting the homologous recombination pathway in nasopharyngeal carcinoma.
Neoplasms
Olaparib hydroxamic acid derivatives as dual PARP and HDAC inhibitors for cancer therapy.
Neoplasms
Oleandrin induces DNA damage responses in cancer cells by suppressing the expression of Rad51.
Neoplasms
Ortholog of BRCA2-interacting protein BCCIP controls morphogenetic responses during DNA replication stress in Ustilago maydis.
Neoplasms
Over-expression of wild-type Rad51 correlates with histological grading of invasive ductal breast cancer.
Neoplasms
Overexpression of mammalian Rad51 does not stimulate tumorigenesis while a dominant-negative Rad51 affects centrosome fragmentation, ploidy and stimulates tumorigenesis, in p53-defective CHO cells.
Neoplasms
Overexpression of Rad51 predicts poor prognosis and silencing of Rad51 increases chemo-sensitivity to doxorubicin in neuroblastoma.
Neoplasms
Overexpression of Rad51 Predicts Poor Prognosis in Colorectal Cancer: Our Experience with 54 Patients.
Neoplasms
Overexpression of RAD51 suppresses recombination defects: a possible mechanism to reverse genomic instability.
Neoplasms
Overexpression of SKP2 promotes the radiation resistance of esophageal squamous cell carcinoma.
Neoplasms
Oxidative Stress and DNA Damage in Human Gastric Carcinoma: 8-Oxo-7'8-dihydro-2'-deoxyguanosine (8-oxo-dG) as a Possible Tumor Marker.
Neoplasms
Palb2 synergizes with Trp53 to suppress mammary tumor formation in a model of inherited breast cancer.
Neoplasms
PALB2: the hub of a network of tumor suppressors involved in DNA damage responses.
Neoplasms
Panobinostat sensitizes cyclin E high, homologous recombination-proficient ovarian cancer to olaparib.
Neoplasms
PARP1-dependent recruitment of KDM4D histone demethylase to DNA damage sites promotes double-strand break repair.
Neoplasms
Pathogenic and likely pathogenic variants in PALB2, CHEK2, and other known breast cancer susceptibility genes among 1054 BRCA-negative Hispanics with breast cancer.
Neoplasms
Pathology and gene expression of hereditary breast tumors associated with BRCA1, BRCA2 and CHEK2 gene mutations.
Neoplasms
Phase 1 Combination Study of the CHK1 Inhibitor Prexasertib and the PARP Inhibitor Olaparib in High-grade Serous Ovarian Cancer and Other Solid Tumors.
Neoplasms
Phase I trial of TRC102 (methoxyamine HCl) in combination with temozolomide in patients with relapsed solid tumors and lymphomas.
Neoplasms
Phase II clinical study of valproic acid plus cisplatin and cetuximab in recurrent and/or metastatic squamous cell carcinoma of Head and Neck-V-CHANCE trial.
Neoplasms
Pilot study examining tumor expression of RAD51 and clinical outcomes in human head cancers.
Neoplasms
Plk1 and CK2 act in concert to regulate Rad51 during DNA double strand break repair.
Neoplasms
Polymorphic Variants in 5'-UTR Regions of the RAD51 Gene are Associated With RAD51 Expression and Triple-Negative Breast Cancer (TNBC): A Case-Control Study.
Neoplasms
Polymorphism of the homologous recombination repair genes RAD51 and XRCC3 in breast cancer.
Neoplasms
Polymorphisms in cancer susceptibility genes XRCC1, RAD51 and TP53 and the risk of breast cancer in Serbian women.
Neoplasms
Polymorphisms in RAD51, XRCC2 and XRCC3 genes of the homologous recombination repair in colorectal cancer-a case control study.
Neoplasms
Positive effect of single nucleotide RAD51 135G>C polymorphism and low Ku70 protein expression on female rectal cancer patients survival after preoperative radiotherapy.
Neoplasms
Precision medicine phase II study evaluating the efficacy of a double immunotherapy by durvalumab and tremelimumab combined with olaparib in patients with solid cancers and carriers of homologous recombination repair genes mutation in response or stable after olaparib treatment.
Neoplasms
Predicting Radiosensitivity with Gamma-H2AX Foci Assay after Single High-Dose-Rate and Pulsed Dose-Rate Ionizing Irradiation.
Neoplasms
Prevalence of Homologous Recombination-Related Gene Mutations Across Multiple Cancer Types.
Neoplasms
Prexasertib treatment induces homologous recombination deficiency and synergizes with olaparib in triple-negative breast cancer cells.
Neoplasms
PRKC-? Expression Promotes the Aggressive Phenotype of Human Prostate Cancer Cells and Is a Novel Target for Therapeutic Intervention.
Neoplasms
Prodigiosin-induced cytotoxicity involves RAD51 down-regulation through the JNK and p38 MAPK pathways in human breast carcinoma cell lines.
Neoplasms
Prognostic and predictive value of loss of nuclear RAD51 immunoreactivity in resected non-small cell lung cancer patients.
Neoplasms
Prognostic Impact of DNA Repair Protein Expression in Non-Small Cell Lung Cancers Treated with Platinum-Based Chemotherapy and Subsequent Curative Lung Resection.
Neoplasms
Progranulin promotes Temozolomide resistance of glioblastoma by orchestrating DNA repair and tumor stemness.
Neoplasms
Promotion of BRCA2-Dependent Homologous Recombination by DSS1 via RPA Targeting and DNA Mimicry.
Neoplasms
Promotion of presynaptic filament assembly by the ensemble of S. cerevisiae Rad51 paralogues with Rad52.
Neoplasms
Protective role of miR-155 in breast cancer through RAD51 targeting impairs homologous recombination after irradiation.
Neoplasms
Proteomic Features of Colorectal Cancer Identify Tumor Subtypes Independent of Oncogenic Mutations and Independently Predict Relapse-Free Survival.
Neoplasms
PTEN Deletion in Prostate Cancer Cells Does Not Associate with Loss of RAD51 Function: Implications for Radiotherapy and Chemotherapy.
Neoplasms
Quantitative imaging of RAD51 expression as a marker of platinum resistance in ovarian cancer.
Neoplasms
RAB22 and RAB163/mouse BRCA2: proteins that specifically interact with the RAD51 protein.
Neoplasms
RAD-51-dependent and -independent roles of a Caenorhabditis elegans BRCA2-related protein during DNA double-strand break repair.
Neoplasms
RAD51 135G>C and TP53 Arg72Pro polymorphisms and susceptibility to breast cancer in Serbian women.
Neoplasms
RAD51 135G>C does not modify breast cancer risk in non-BRCA1/2 mutation carriers: evidence from a meta-analysis of 12 studies.
Neoplasms
RAD51 as a candidate parathyroid tumour suppressor gene on chromosome 15q: absence of somatic mutations.
Neoplasms
RAD51 as a potential surrogate marker for DNA repair capacity in solid malignancies.
Neoplasms
Rad51 Expression in Nasopharyngeal Carcinoma and Its Association with Tumor Reduction: A Preliminary Study in Indonesia.
Neoplasms
Rad51 Expression Is a Useful Predictive Factor for the Efficacy of Neoadjuvant Chemoradiotherapy in Squamous Cell Carcinoma of the Esophagus.
Neoplasms
RAD51 foci as a functional biomarker of homologous recombination repair and PARP inhibitor resistance in germline BRCA-mutated breast cancer.
Neoplasms
RAD51 Gene 135G/C polymorphism and the risk of four types of common cancers: a meta-analysis.
Neoplasms
RAD51 inhibition in triple negative breast cancer cells is challenged by compensatory survival signaling and requires rational combination therapy.
Neoplasms
Rad51 inhibition is an effective means of targeting DNA repair in glioma models and CD133+ tumor derived cells.
Neoplasms
Rad51 inhibits translocation formation by non-conservative homologous recombination in Saccharomyces cerevisiae.
Neoplasms
RAD51 interacts with the evolutionarily conserved BRC motifs in the human breast cancer susceptibility gene brca2.
Neoplasms
RAD51 is a potential marker for prognosis and regulates cell proliferation in pancreatic cancer.
Neoplasms
RAD51 Mediates Resistance of Cancer Stem Cells to PARP Inhibition in Triple-Negative Breast Cancer.
Neoplasms
Rad51 overexpression and resistance to genotoxic agents. A study in the fission yeast Schizosaccharomyces pombe.
Neoplasms
RAD51 overexpression is a negative prognostic marker for colorectal adenocarcinoma.
Neoplasms
Rad51 overexpression promotes alternative double-strand break repair pathways and genome instability.
Neoplasms
Rad51 overexpression rescues radiation resistance in BRCA2-defective cancer cells.
Neoplasms
RAD51 paralogs promote genomic integrity and chemoresistance in cancer by facilitating homologous recombination.
Neoplasms
Rad51 Paralogs Remodel Pre-synaptic Rad51 Filaments to Stimulate Homologous Recombination.
Neoplasms
RAD51 paralogs: Roles in DNA damage signalling, recombinational repair and tumorigenesis.
Neoplasms
Rad51 paralogues Rad55-Rad57 balance the antirecombinase Srs2 in Rad51 filament formation.
Neoplasms
Rad51 promoter-targeted gene therapy is effective for in vivo visualization and treatment of cancer.
Neoplasms
RAD51 regulates CHK1 stability via autophagy to promote cell growth in esophageal squamous carcinoma cells.
Neoplasms
Rad51 siRNA delivered by HVJ envelope vector enhances the anti-cancer effect of cisplatin.
Neoplasms
RAD51 variant proteins from human lung and kidney tumors exhibit DNA strand exchange defects.
Neoplasms
RAD51-associated protein 1 (RAD51AP1) interacts with the meiotic recombinase DMC1 through a conserved motif.
Neoplasms
RAD51-Mediated DNA Homologous Recombination Is Independent of PTEN Mutational Status.
Neoplasms
RAD51D splice variants and cancer-associated mutations reveal XRCC2 interaction to be critical for homologous recombination.
Neoplasms
RAD54 family translocases counter genotoxic effects of RAD51 in human tumor cells.
Neoplasms
Radiation-induced synthetic lethality: combination of poly(ADP-ribose) polymerase and RAD51 inhibitors to sensitize cells to proton irradiation.
Neoplasms
RASSF1A-LATS1 signalling stabilizes replication forks by restricting CDK2-mediated phosphorylation of BRCA2.
Neoplasms
Real-time solution measurement of RAD51- and RecA-mediated strand assimilation without background annealing.
Neoplasms
Recent Developments Using Small Molecules to Target RAD51: How to Best Modulate RAD51 for Anticancer Therapy?
Neoplasms
RECQL5/Recql5 helicase regulates homologous recombination and suppresses tumor formation via disruption of Rad51 presynaptic filaments.
Neoplasms
Regulation of RAD51 at the Transcriptional and Functional Levels: What Prospects for Cancer Therapy?
Neoplasms
Relationship between Rad51 G135C and G172T variants and the susceptibility to cancer: a meta-analysis involving 54 case-control studies.
Neoplasms
Replication protein A: a multifunctional protein with roles in DNA replication, repair and beyond.
Neoplasms
Reversion and non-reversion mechanisms of resistance to PARP inhibitor or platinum chemotherapy in BRCA1/2-mutant metastatic breast cancer.
Neoplasms
Ribozyme minigene-mediated RAD51 down-regulation increases radiosensitivity of human prostate cancer cells.
Neoplasms
Role of the RAD51 G172T polymorphism in the clinical outcome of cervical cancer patients under concomitant chemoradiotherapy.
Neoplasms
Rosiglitazone enhances radiosensitivity by inhibiting repair of DNA damage in cervical cancer cells.
Neoplasms
Screening for RAD51 and BRCA2 BRC repeat mutations in breast and ovarian cancer families.
Neoplasms
Sensitization of Pancreatic Cancers to Gemcitabine Chemoradiation by WEE1 Kinase Inhibition Depends on Homologous Recombination Repair.
Neoplasms
Sensitization of tumor to (212)pb radioimmunotherapy by gemcitabine involves initial abrogation of g2 arrest and blocked DNA damage repair by interference with rad51.
Neoplasms
Sequence fingerprints in BRCA2 and RAD51: implications for DNA repair and cancer.
Neoplasms
Sequential role of RAD51 paralog complexes in replication fork remodeling and restart.
Neoplasms
Single Nucleotide Polymorphisms (SNPs) of RAD51-G172T and XRCC2-41657C/T Homologous Recombination Repair Genes and the Risk of Triple- Negative Breast Cancer in Polish Women.
Neoplasms
Single-Cell Transcriptome Analysis Dissects the Replicating Process of Pancreatic Beta Cells in Partial Pancreatectomy Model.
Neoplasms
Single-molecule localization microscopy reveals molecular transactions during RAD51 filament assembly at cellular DNA damage sites.
Neoplasms
Slug/?-Catenin-Dependent Proinflammatory Phenotype in Hypoxic Breast Cancer Stem Cells.
Neoplasms
Somatic SNPs of the BRCA2 gene at the fragments encoding RAD51 binding sites of canine mammary tumors.
Neoplasms
Stabilization of RAD-51-DNA filaments via an interaction domain in Caenorhabditis elegans BRCA2.
Neoplasms
Synthesis, molecular modeling, and biological evaluation of novel RAD51 inhibitors.
Neoplasms
Synthetic Lethality of PARP Inhibitors in Combination with MYC Blockade Is Independent of BRCA Status in Triple-Negative Breast Cancer.
Neoplasms
Systematic Screen Identifies miRNAs that Target RAD51 and RAD51D to Enhance Chemosensitivity.
Neoplasms
Targeting homologous recombination by pharmacological inhibitors enhances the killing response of glioblastoma cells treated with alkylating drugs.
Neoplasms
Targeting homologous recombination using imatinib results in enhanced tumor cell chemosensitivity and radiosensitivity.
Neoplasms
Targeting homologous recombination, new pre-clinical and clinical therapeutic combinations inhibiting RAD51.
Neoplasms
Targeting human Rad51 by specific DNA aptamers induces inhibition of homologous recombination.
Neoplasms
Targeting PI3K and RAD51 in Barrett's Adenocarcinoma: Impact on DNA Damage Checkpoints, Expression Profile and Tumor Growth.
Neoplasms
Targeting RAD51 enhances chemosensitivity of adult T?cell leukemia?lymphoma cells by reducing DNA double?strand break repair.
Neoplasms
The ?-isoform of BCCIP promotes ADP release from the RAD51 presynaptic filament and enhances homologous DNA pairing.
Neoplasms
The association between polymorphisms of the RAD51-G135C, XRCC2-Arg188His and XRCC3-Thr241Met genes and clinico-pathologic features in breast cancer in Poland.
Neoplasms
The Bloom syndrome protein limits the lethality associated with RAD51 deficiency.
Neoplasms
The BRCA Tumor Suppressor Network in Chromosome Damage Repair by Homologous Recombination.
Neoplasms
The BRCA1/BRCA2/Rad51 complex is a prognostic and predictive factor in early breast cancer.
Neoplasms
The breast cancer tumor suppressor BRCA2 promotes the specific targeting of RAD51 to single-stranded DNA.
Neoplasms
The combination of chemotherapy with HVJ-E containing Rad51 siRNA elicited diverse anti-tumor effects and synergistically suppressed melanoma.
Neoplasms
The functions of breast cancer susceptibility gene 1 (BRCA1) product and its associated proteins.
Neoplasms
The homologous recombination protein RAD51 is a promising therapeutic target for cervical carcinoma.
Neoplasms
The human Shu complex functions with PDS5B and SPIDR to promote homologous recombination.
Neoplasms
The impact of functional LIG4 polymorphism on platinum-based chemotherapy response and survival in non-small cell lung cancer.
Neoplasms
The novel ATR inhibitor VE-821 increases sensitivity of pancreatic cancer cells to radiation and chemotherapy.
Neoplasms
The potential value of the neutral comet assay and the expression of genes associated with DNA damage in assessing the radiosensitivity of tumor cells.
Neoplasms
The purine scaffold Hsp90 inhibitor PU-H71 sensitizes cancer cells to heavy ion radiation by inhibiting DNA repair by homologous recombination and non-homologous end joining.
Neoplasms
The RAD51 135 G>C polymorphism modifies breast cancer and ovarian cancer risk in Polish BRCA1 mutation carriers.
Neoplasms
The RAD51 135G>C polymorphism is related to the effect of adjuvant therapy in early breast cancer.
Neoplasms
The Rad51 paralog complex Rad55-Rad57 acts as a molecular chaperone during homologous recombination.
Neoplasms
The RAD51-stimulatory compound RS-1 can exploit the RAD51 overexpression that exists in cancer cells and tumors.
Neoplasms
The RECAP Test Rapidly and Reliably Identifies Homologous Recombination-Deficient Ovarian Carcinomas.
Neoplasms
The relevance of prelamin A and RAD51 as molecular biomarkers in cervical cancer.
Neoplasms
The role of microRNA-binding site polymorphisms in DNA repair genes as risk factors for bladder cancer and breast cancer and their impact on radiotherapy outcomes.
Neoplasms
The Valproate Mediates Radio-Bidirectional Regulation Through RFWD3-Dependent Ubiquitination on Rad51.
Neoplasms
Therapeutic Potential of PARP Inhibitors in the Treatment of Gastrointestinal Cancers.
Neoplasms
TODRA, a lncRNA at the RAD51 Locus, Is Oppositely Regulated to RAD51, and Enhances RAD51-Dependent DSB (Double Strand Break) Repair.
Neoplasms
Towards rational design of RAD51-targeting prodrugs: platinumIV-artesunate conjugates with enhanced cytotoxicity against BRCA-proficient ovarian and breast cancer cells.
Neoplasms
TP53 Binding to BRCA1 and RAD51 in MCF7 and MDA-MB-468 Breast Cancer Cell Lines In vivo and In vitro.
Neoplasms
Treatment of Nasopharyngeal Carcinoma Cells with the Histone-Deacetylase Inhibitor Abexinostat: Cooperative Effects with Cis-platin and Radiotherapy on Patient-Derived Xenografts.
Neoplasms
Treatment Outcome and Prognostic Molecular Markers of Supratentorial Primitive Neuroectodermal Tumors.
Neoplasms
Tumor Cell Kill by c-MYC Depletion: Role of MYC-Regulated Genes that Control DNA Double-Strand Break Repair.
Neoplasms
Tumor-associated mutations in a conserved structural motif alter physical and biochemical properties of human RAD51 recombinase.
Neoplasms
Upregulation of RAD51 expression is associated with progression of thyroid carcinoma.
Neoplasms
Variation in RAD51 details a hub of functions: opportunities to advance cancer diagnosis and therapy.
Neoplasms
XAB2 promotes Ku eviction from single-ended DNA double-strand breaks independently of the ATM kinase.
Neoplasms
XRCC1 Arg399Gln and RAD51 5'UTR G135C polymorphisms and their outcome in tumor aggressiveness and survival of Portuguese breast cancer patients.
Neoplasms
YM155 and BIRC5 downregulation induce genomic instability via autophagy-mediated ROS production and inhibition in DNA repair.
Neoplasms
[Association of polymorphisms of N372H in BRCA2 gene and 135G/C in RAD51 gene and breast cancers]
Neoplasms
[Expression of RAD51 in carcinomas of cancer of larynx and its clinical significance]
Neoplasms
[Human RAD51 recombinase: the role in the cell cycle checkpoint and cellular survival]
Neoplasms, Squamous Cell
High-level expression of Rad51 is an independent prognostic marker of survival in non-small-cell lung cancer patients.
Neuroblastoma
Gene expression profiles and protein-protein interaction networks in neuroblastoma with MEIS2 depletion.
Neuroblastoma
Overexpression of Rad51 predicts poor prognosis and silencing of Rad51 increases chemo-sensitivity to doxorubicin in neuroblastoma.
Neurofibromatoses
Pathogenic and likely pathogenic variants in PALB2, CHEK2, and other known breast cancer susceptibility genes among 1054 BRCA-negative Hispanics with breast cancer.
Neurofibromatosis 1
Pathogenic and likely pathogenic variants in PALB2, CHEK2, and other known breast cancer susceptibility genes among 1054 BRCA-negative Hispanics with breast cancer.
Nijmegen Breakage Syndrome
Plk1 and CK2 act in concert to regulate Rad51 during DNA double strand break repair.
Osteosarcoma
Berberine enhances the radiosensitivity of osteosarcoma by targeting Rad51 and epithelial-mesenchymal transition.
Osteosarcoma
Essential roles of Jab1 in cell survival, spontaneous DNA damage and DNA repair.
Osteosarcoma
Genetic Association between ERCC2, NBN, RAD51 Gene Variants and Osteosarcoma Risk: a Systematic Review and Meta-Analysis
Osteosarcoma
Human Rad51 promotes mitochondrial DNA synthesis under conditions of increased replication stress.
Osteosarcoma
Knockdown of Rad51 expression induces radiation- and chemo-sensitivity in osteosarcoma cells.
Osteosarcoma
Long Noncoding RNA HCG9 Promotes Osteosarcoma Progression through RAD51 by Acting as a ceRNA of miR-34b-3p.
Osteosarcoma
Systematic Screen Identifies miRNAs that Target RAD51 and RAD51D to Enhance Chemosensitivity.
Ovarian Neoplasms
53BP1 as a potential predictor of response in PARP inhibitor-treated homologous recombination-deficient ovarian cancer.
Ovarian Neoplasms
A region of human BRCA2 containing multiple BRC repeats promotes RAD51-mediated strand exchange.
Ovarian Neoplasms
A single nucleotide polymorphism in the 5' untranslated region of RAD51 and ovarian cancer risk in Polish women.
Ovarian Neoplasms
A single nucleotide polymorphism in the 5' untranslated region of RAD51 and risk of cancer among BRCA1/2 mutation carriers.
Ovarian Neoplasms
A single nucleotide polymorphism in the RAD51 gene modifies cancer risk in BRCA2 but not BRCA1 carriers.
Ovarian Neoplasms
An ex vivo assay of XRT-induced Rad51 foci formation predicts response to PARP-inhibition in ovarian cancer.
Ovarian Neoplasms
Artesunate sensitizes ovarian cancer cells to cisplatin by downregulating RAD51.
Ovarian Neoplasms
Association between polymorphisms of the DNA repair gene RAD51 and ovarian cancer.
Ovarian Neoplasms
Association between RAD51, XRCC2 and XRCC3 gene polymorphisms and risk of ovarian cancer: a case control and an in silico study.
Ovarian Neoplasms
Augmentation of response to chemotherapy by microRNA-506 through regulation of RAD51 in serous ovarian cancers.
Ovarian Neoplasms
CDCA8, targeted by MYBL2, promotes malignant progression and olaparib insensitivity in ovarian cancer.
Ovarian Neoplasms
Clinicopathological values of NBS1 and DNA damage response genes in epithelial ovarian cancers.
Ovarian Neoplasms
Contribution of germline deleterious variants in the RAD51 paralogs to breast and ovarian cancers.
Ovarian Neoplasms
Contribution of Germline Mutations in the RAD51B, RAD51C, and RAD51D Genes to Ovarian Cancer in the Population.
Ovarian Neoplasms
Cyclin D1 silencing impairs DNA double strand break repair, sensitizes BRCA1 wildtype ovarian cancer cells to olaparib.
Ovarian Neoplasms
Distinct roles of FANCO/RAD51C protein in DNA damage signaling and repair: implications for Fanconi anemia and breast cancer susceptibility.
Ovarian Neoplasms
Double-strand break repair gene polymorphisms and risk of breast or ovarian cancer.
Ovarian Neoplasms
Downregulation of the cancer susceptibility protein WRAP53? in epithelial ovarian cancer leads to defective DNA repair and poor clinical outcome.
Ovarian Neoplasms
Emerging roles of lamins and DNA damage repair mechanisms in ovarian cancer.
Ovarian Neoplasms
Enhanced non-homologous end joining contributes toward synthetic lethality of pathological RAD51C mutants with poly (ADP-ribose) polymerase.
Ovarian Neoplasms
Enhancing the sensitivity of ovarian cancer cells to olaparib via microRNA-20b-mediated cyclin D1 targeting.
Ovarian Neoplasms
Exploring the Frequency of Homologous Recombination DNA Repair Dysfunction in Multiple Cancer Types.
Ovarian Neoplasms
Germline mutation in the RAD51B gene confers predisposition to breast cancer.
Ovarian Neoplasms
Germline polymorphisms in an enhancer of PSIP1 are associated with progression-free survival in epithelial ovarian cancer.
Ovarian Neoplasms
Human DNA helicase HELQ participates in DNA interstrand crosslink tolerance with ATR and RAD51 paralogs.
Ovarian Neoplasms
Identification of DNA Repair Pathways that Affect the Survival of Ovarian Cancer Cells Treated with a PARP Inhibitor in a Novel Drug Combination.
Ovarian Neoplasms
MicroRNA regulation of RAD51 in serous ovarian cancer modulates chemotherapy response.
Ovarian Neoplasms
miR-506: a regulator of chemo-sensitivity through suppression of the RAD51-homologous recombination axis.
Ovarian Neoplasms
MiR-509-3 augments the synthetic lethality of PARPi by regulating HR repair in PDX model of HGSOC.
Ovarian Neoplasms
Mitochondrial superoxide contributes to oxidative stress exacerbated by DNA damage response in RAD51-depleted ovarian cancer cells.
Ovarian Neoplasms
Modification of BRCA1-Associated Breast and Ovarian Cancer Risk by BRCA1 Interacting Genes.
Ovarian Neoplasms
Modification of ovarian cancer risk by BRCA1/2-interacting genes in a multicenter cohort of BRCA1/2 mutation carriers.
Ovarian Neoplasms
Mutation analysis of RAD51L1 (RAD51B/REC2) in multiple-case, non-BRCA1/2 breast cancer families.
Ovarian Neoplasms
Pathogenic and likely pathogenic variants in PALB2, CHEK2, and other known breast cancer susceptibility genes among 1054 BRCA-negative Hispanics with breast cancer.
Ovarian Neoplasms
Precision medicine phase II study evaluating the efficacy of a double immunotherapy by durvalumab and tremelimumab combined with olaparib in patients with solid cancers and carriers of homologous recombination repair genes mutation in response or stable after olaparib treatment.
Ovarian Neoplasms
Predictive value of RAD51 on the survival and drug responsiveness of ovarian cancer.
Ovarian Neoplasms
Quantitative imaging of RAD51 expression as a marker of platinum resistance in ovarian cancer.
Ovarian Neoplasms
RAD51 and BRCA2 Enhance Oncolytic Adenovirus Type 5 Activity in Ovarian Cancer.
Ovarian Neoplasms
RAD51 and breast cancer susceptibility: no evidence for rare variant association in the Breast Cancer Family Registry study.
Ovarian Neoplasms
RAD51 Gene 135G/C polymorphism and the risk of four types of common cancers: a meta-analysis.
Ovarian Neoplasms
RAD51, XRCC3, and XRCC2 mutation screening in Finnish breast cancer families.
Ovarian Neoplasms
Screening for RAD51 and BRCA2 BRC repeat mutations in breast and ovarian cancer families.
Ovarian Neoplasms
Sulfolobus tokodaii RadA paralog, stRadC2, is involved in DNA recombination via interaction with RadA and Hjc.
Ovarian Neoplasms
The BRC repeats of human BRCA2 differentially regulate RAD51 binding on single- versus double-stranded DNA to stimulate strand exchange.
Ovarian Neoplasms
The carboxyl-terminal of BRCA1 is required for subnuclear assembly of RAD51 after treatment with cisplatin but not ionizing radiation in human breast and ovarian cancer cells.
Ovarian Neoplasms
The effect of RAD51 135 G>C and XRCC2 G>A (rs3218536) polymorphisms on ovarian cancer risk among Caucasians: a meta-analysis.
Ovarian Neoplasms
The RAD51 135 G>C polymorphism modifies breast cancer and ovarian cancer risk in Polish BRCA1 mutation carriers.
Ovarian Neoplasms
Two modules in the BRC repeats of BRCA2 mediate structural and functional interactions with the RAD51 recombinase.
Pancreatic Neoplasms
Autoantibodies in sera of pancreatic cancer patients identify recombination factor Rad51 as a tumour-associated antigen.
Pancreatic Neoplasms
DNA repair and recombination factor Rad51 is over-expressed in human pancreatic adenocarcinoma.
Pancreatic Neoplasms
Gemcitabine sensitization by checkpoint kinase 1 inhibition correlates with inhibition of a Rad51 DNA damage response in pancreatic cancer cells.
Pancreatic Neoplasms
Network Analysis of RAD51 Proteins in Metazoa and the Evolutionary Relationships With Their Archaeal Homologs.
Pancreatic Neoplasms
Overexpression of KLF5 is associated with poor survival and G1/S progression in pancreatic cancer.
Pancreatic Neoplasms
Precision medicine phase II study evaluating the efficacy of a double immunotherapy by durvalumab and tremelimumab combined with olaparib in patients with solid cancers and carriers of homologous recombination repair genes mutation in response or stable after olaparib treatment.
Pancreatic Neoplasms
RAD51 as a potential biomarker and therapeutic target for pancreatic cancer.
Pancreatic Neoplasms
RAD51 is a potential marker for prognosis and regulates cell proliferation in pancreatic cancer.
Pancreatic Neoplasms
The association of changes in RAD51 and survivin expression levels with the proton beam sensitivity of Capan?1 and Panc?1 human pancreatic cancer cells.
Pancreatic Neoplasms
The BRC repeats in BRCA2 are critical for RAD51 binding and resistance to methyl methanesulfonate treatment.
Pancreatic Neoplasms
The effects of SAHA on radiosensitivity in pancreatic cancer cells by inducing apoptosis and targeting RAD51.
Papilloma
Inhibiting the MCM8-9 complex selectively sensitizes cancer cells to cisplatin and olaparib.
Parathyroid Neoplasms
RAD51 as a candidate parathyroid tumour suppressor gene on chromosome 15q: absence of somatic mutations.
Precancerous Conditions
Overexpression of mammalian Rad51 does not stimulate tumorigenesis while a dominant-negative Rad51 affects centrosome fragmentation, ploidy and stimulates tumorigenesis, in p53-defective CHO cells.
Prostatic Neoplasms
Coordinate alterations in the expression of BRCA1, BRCA2, p300, and Rad51 in response to genotoxic and other stresses in human prostate cancer cells.
Prostatic Neoplasms
Does PTEN Loss Impair DNA Double-Strand Break Repair by Homologous Recombination?
Prostatic Neoplasms
Dynamic Regulation of Rad51 by E2F1 and p53 in Prostate Cancer Cells upon DrugInduced DNA Damage under Hypoxia.
Prostatic Neoplasms
Germline Mutations in DNA Repair Genes in Patients With Metastatic Castration-resistant Prostate Cancer.
Prostatic Neoplasms
Impaired homologous recombination DNA repair and enhanced sensitivity to DNA damage in prostate cancer cells exposed to anchorage-independence.
Prostatic Neoplasms
Loss of heterozygosity for chromosomal regions 15q14-21.1, 17q21.31, and 13q12.3-13.1 and its relevance for prostate cancer.
Prostatic Neoplasms
Loss of PTEN-assisted G2/M checkpoint impedes homologous recombination repair and enhances radio-curability and PARP inhibitor treatment response in prostate cancer.
Prostatic Neoplasms
Polymorphisms of homologous recombination RAD51, RAD51B, XRCC2, and XRCC3 genes and the risk of prostate cancer.
Prostatic Neoplasms
Precision medicine phase II study evaluating the efficacy of a double immunotherapy by durvalumab and tremelimumab combined with olaparib in patients with solid cancers and carriers of homologous recombination repair genes mutation in response or stable after olaparib treatment.
Prostatic Neoplasms
PTEN Deletion in Prostate Cancer Cells Does Not Associate with Loss of RAD51 Function: Implications for Radiotherapy and Chemotherapy.
Prostatic Neoplasms
RAD51 and XRCC3 Polymorphisms Are Associated with Increased Risk of Prostate Cancer.
Prostatic Neoplasms
Relationship between XPD, RAD51, and APEX1 DNA repair genotypes and prostate cancer risk in the male population of Rio de Janeiro, Brazil.
Prostatic Neoplasms
Ribozyme minigene-mediated RAD51 down-regulation increases radiosensitivity of human prostate cancer cells.
Prostatic Neoplasms
STAT5A/B Blockade Sensitizes Prostate Cancer to Radiation through Inhibition of RAD51 and DNA Repair.
Prostatic Neoplasms
Suppression of homologous recombination sensitizes human tumor cells to IGF-1R inhibition.
Prostatic Neoplasms
Synergistic loss of prostate cancer cell viability by coinhibition of HDAC and PARP.
Prostatic Neoplasms
Targeting c-MET to Enhance the Efficacy of Olaparib in Prostate Cancer.
Prostatic Neoplasms
The RAD51-stimulatory compound RS-1 can exploit the RAD51 overexpression that exists in cancer cells and tumors.
Pulmonary Arterial Hypertension
Bone morphogenetic protein signaling is required for RAD51-mediated maintenance of genome integrity in vascular endothelial cells.
rada recombinase deficiency
Impaired homologous recombination DNA repair and enhanced sensitivity to DNA damage in prostate cancer cells exposed to anchorage-independence.
rada recombinase deficiency
RAD51 deficiency disrupts the corticospinal lateralization of motor control.
rada recombinase deficiency
The Bloom syndrome protein limits the lethality associated with RAD51 deficiency.
rada recombinase deficiency
Yap1 and Skn7 genetically interact with Rad51 in response to oxidative stress and DNA double-strand break in Saccharomyces cerevisiae.
Radiation Pneumonitis
Polymorphisms of homologous recombination genes and clinical outcomes of non-small cell lung cancer patients treated with definitive radiotherapy.
Rectal Neoplasms
A panel of tumor biomarkers to predict complete pathological response to neo-adjuvant treatment in Locally Advanced Rectal Cancer.
Rectal Neoplasms
Evaluation of relation of RAD51 and the effect of chemo-radiation therapy for advanced rectal cancer.
Rectal Neoplasms
Pharmacogenetic Analysis of INT 0144 Trial: Association of Polymorphisms with Survival and Toxicity in Rectal Cancer Patients Treated with 5-FU and Radiation.
Rectal Neoplasms
Positive effect of single nucleotide RAD51 135G>C polymorphism and low Ku70 protein expression on female rectal cancer patients survival after preoperative radiotherapy.
Rectal Neoplasms
Potential Role of Single Nucleotide Polymorphisms of XRCC1, XRCC3, and RAD51 in Predicting Acute Toxicity in Rectal Cancer Patients Treated With Preoperative Radiochemotherapy.
Retinoblastoma
Histological groups of human postpubertal testicular germ cell tumours harbour different genetic alterations.
Retinoblastoma
Multiple DNA damage signaling and repair pathways deregulated by simian virus 40 large T antigen.
Retinoblastoma
The retinoblastoma homolog RBR1 mediates localization of the repair protein RAD51 to DNA lesions in Arabidopsis.
Rhabdomyosarcoma
Enhancement of Soft Tissue Sarcoma Cell Radiosensitivity by Poly(ADP-ribose) Polymerase-1 Inhibitors.
Sarcoma
Common gene variants in RAD51, XRCC2 and XPD are not associated with clinical outcome in soft-tissue sarcoma patients.
Sarcoma
Histone deacetylase inhibitor (HDACI) PCI-24781 potentiates cytotoxic effects of doxorubicin in bone sarcoma cells.
Sarcoma
Histone deacetylase inhibitor PCI-24781 enhances chemotherapy-induced apoptosis in multidrug-resistant sarcoma cell lines.
Sarcoma
Inhibition of AKT-Signaling Sensitizes Soft Tissue Sarcomas (STS) and Gastrointestinal Stromal Tumors (GIST) to Doxorubicin via Targeting of Homology-Mediated DNA Repair.
Sarcoma
Over-expression of RAD51 or RAD54 but not RAD51/4 enhances extra-chromosomal homologous recombination in the human sarcoma (HT-1080) cell line.
Sarcoma
Rad51 overexpression contributes to chemoresistance in human soft tissue sarcoma cells: a role for p53/activator protein 2 transcriptional regulation.
Sarcoma, Synovial
Synovial sarcoma cell lines showed reduced DNA repair activity and sensitivity to a PARP inhibitor.
Seminoma
Histological groups of human postpubertal testicular germ cell tumours harbour different genetic alterations.
Small Cell Lung Carcinoma
The role of RAD51 in etoposide (VP16) resistance in small cell lung cancer.
Squamous Cell Carcinoma of Head and Neck
Combined Inhibition of Rad51 and Wee1 Enhances Cell Killing in HNSCC Through Induction of Apoptosis Associated With Excessive DNA Damage and Replication Stress.
Squamous Cell Carcinoma of Head and Neck
Delayed DNA double-strand break repair following platin-based chemotherapy predicts treatment response in head and neck squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
Expression of RAD51 and Its Clinical Impact in Oral Squamous Cell Carcinoma.
Squamous Cell Carcinoma of Head and Neck
p16INK4a Impairs Homologous Recombination-Mediated DNA Repair in Human Papillomavirus-Positive Head and Neck Tumors.
Squamous Cell Carcinoma of Head and Neck
Polymorphisms of the XRCC3 C722T and the RAD51 G135C genes and the risk of head and neck cancer in a Polish population.
Squamous Cell Carcinoma of Head and Neck
Prognostic significance of head and neck squamous cell carcinoma repair gene polymorphism.
Squamous Cell Carcinoma of Head and Neck
Single-nucleotide polymorphisms in DNA double-strand break repair genes: Association with head and neck cancer and interaction with tobacco use and alcohol consumption.
Squamous Cell Carcinoma of Head and Neck
Smad4 loss in mice causes spontaneous head and neck cancer with increased genomic instability and inflammation.
Stomach Neoplasms
CRIP1 cooperates with BRCA2 to drive the nuclear enrichment of RAD51 and to facilitate homologous repair upon DNA damage induced by chemotherapy.
Stomach Neoplasms
DNA damage and repair in gastric cancer--a correlation with the hOGG1 and RAD51 genes polymorphisms.
Stomach Neoplasms
Genetic polymorphisms of DNA repair pathways influence the response to chemotherapy and overall survival of gastric cancer.
Stomach Neoplasms
Interferon regulatory factor-1 suppresses DNA damage response and reverses chemotherapy resistance by downregulating the expression of RAD51 in gastric cancer.
Stomach Neoplasms
RAD51 G135C genetic polymorphism and their potential role in gastric cancer induced by Helicobacter pylori infection in Bhutan.
Stomach Neoplasms
RAD51 potentiates synergistic effects of chemotherapy with PCI-24781 and cis-diamminedichloroplatinum on gastric cancer.
Stomach Neoplasms
The intricate interplay between MSI and polymorphisms of DNA repair enzymes in gastric cancer H.pylori associated.
Stomatitis
Biomarkers in the assessment of oral mucositis in head and neck cancer patients: a systematic review and meta-analysis.
Telangiectasis
A UVR-Induced G2-Phase Checkpoint Response to ssDNA Gaps Produced by Replication Fork Bypass of Unrepaired Lesions Is Defective in Melanoma.
Telangiectasis
Akt/PKB suppresses DNA damage processing and checkpoint activation in late G2.
Telangiectasis
hMOF reduction enhances radiosensitivity through the homologous recombination pathway in non-small-cell lung cancer.
Telangiectasis
Mechanisms of genome maintenance and rearrangement: current research and recent advances in DNA repair and recombination.
Telangiectasis
Pathogenic and likely pathogenic variants in PALB2, CHEK2, and other known breast cancer susceptibility genes among 1054 BRCA-negative Hispanics with breast cancer.
Thyroid Cancer, Papillary
BRCA2 3'-UTR Polymorphism rs15869 Alters Susceptibility to Papillary Thyroid Carcinoma via Binding hsa-mir-1178-3p.
Thyroid Cancer, Papillary
RAD52 polymorphisms contribute to the development of papillary thyroid cancer susceptibility in Middle Eastern population.
Thyroid Neoplasms
Association of polymorphisms in genes of the homologous recombination DNA repair pathway and thyroid cancer risk.
Thyroid Neoplasms
Increased risk of differentiated thyroid carcinoma with combined effects of homologous recombination repair gene polymorphisms in an Iranian population.
Thyroid Neoplasms
Network Analysis of RAD51 Proteins in Metazoa and the Evolutionary Relationships With Their Archaeal Homologs.
Thyroid Neoplasms
Upregulation of RAD51 expression is associated with progression of thyroid carcinoma.
Triple Negative Breast Neoplasms
Association of RAD51 with Homologous Recombination Deficiency (HRD) and clinical outcomes in untreated triple-negative breast cancer (TNBC): analysis of the GeparSixto randomized clinical trial.
Triple Negative Breast Neoplasms
Checkpoint Kinase 1 (CHK1) Inhibition Enhances the Sensitivity of Triple-Negative Breast Cancer Cells to Proton Irradiation via Rad51 Downregulation.
Triple Negative Breast Neoplasms
DDB2 depletion sensitizes triple-negative breast cancer cells to PARP inhibition by destabilizing Rad51.
Triple Negative Breast Neoplasms
Metformin overcomes resistance to cisplatin in triple-negative breast cancer (TNBC) cells by targeting RAD51.
Triple Negative Breast Neoplasms
Polymorphic Variants in 5'-UTR Regions of the RAD51 Gene are Associated With RAD51 Expression and Triple-Negative Breast Cancer (TNBC): A Case-Control Study.
Triple Negative Breast Neoplasms
Protective role of miR-155 in breast cancer through RAD51 targeting impairs homologous recombination after irradiation.
Triple Negative Breast Neoplasms
Quinazolinone derivatives as inhibitors of homologous recombinase RAD51.
Triple Negative Breast Neoplasms
RAD51 genotype and triple-negative breast cancer (TNBC) risk in Polish women.
Triple Negative Breast Neoplasms
RAD51 inhibition in triple negative breast cancer cells is challenged by compensatory survival signaling and requires rational combination therapy.
Triple Negative Breast Neoplasms
Rad51 inhibition sensitizes breast cancer stem cells to PARP inhibitor in triple-negative breast cancer.
Triple Negative Breast Neoplasms
RAD51 Mediates Resistance of Cancer Stem Cells to PARP Inhibition in Triple-Negative Breast Cancer.
Triple Negative Breast Neoplasms
Single Nucleotide Polymorphisms (SNPs) of RAD51-G172T and XRCC2-41657C/T Homologous Recombination Repair Genes and the Risk of Triple- Negative Breast Cancer in Polish Women.
Urinary Bladder Neoplasms
Ex vivo assays to predict enhanced chemosensitization by hyperthermia in urothelial cancer of the bladder.
Urinary Bladder Neoplasms
Imatinib radiosensitizes bladder cancer by targeting homologous recombination.
Urinary Bladder Neoplasms
Susceptibility of XPD and RAD51 Genetic Variants to Carcinoma of Urinary Bladder in North Indian Population.
Uterine Cervical Neoplasms
Association of RAD51 and XRCC2 Gene Polymorphisms with Cervical Cancer Risk in the Bangladeshi Women.
Uterine Cervical Neoplasms
Inhibition of RAD51 by siRNA and Resveratrol Sensitizes Cancer Stem Cells Derived from HeLa Cell Cultures to Apoptosis.
Uterine Cervical Neoplasms
miR-4429 sensitized cervical cancer cells to irradiation by targeting RAD51.
Uterine Cervical Neoplasms
Role of the RAD51 G172T polymorphism in the clinical outcome of cervical cancer patients under concomitant chemoradiotherapy.
Uterine Cervical Neoplasms
Rosiglitazone enhances radiosensitivity by inhibiting repair of DNA damage in cervical cancer cells.
Uterine Cervical Neoplasms
Single nucleotide polymorphisms in DNA repair genes and risk of cervical cancer: A case-control study.
Uterine Cervical Neoplasms
T0070907 inhibits repair of radiation-induced DNA damage by targeting RAD51.
Uterine Cervical Neoplasms
Targeting NEK2 impairs oncogenesis and radioresistance via inhibiting the Wnt1/?-catenin signaling pathway in cervical cancer.
Uterine Cervical Neoplasms
The homologous recombination protein RAD51 is a promising therapeutic target for cervical carcinoma.
Uterine Cervical Neoplasms
The relevance of prelamin A and RAD51 as molecular biomarkers in cervical cancer.
Werner Syndrome
Werner syndrome protein participates in a complex with RAD51, RAD54, RAD54B and ATR in response to ICL-induced replication arrest.
Xeroderma Pigmentosum
Mechanisms of genome maintenance and rearrangement: current research and recent advances in DNA repair and recombination.
Xeroderma Pigmentosum
Susceptibility of XPD and RAD51 Genetic Variants to Carcinoma of Urinary Bladder in North Indian Population.
Xeroderma Pigmentosum
XPG Asp1104His, XRCC2 Rs3218536 A/G and RAD51 135G/C Gene Polymorphisms and Colorectal Cancer Risk: A Meta-Analysis
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pH RANGE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
evolution
the enzyme belongs to the RecA/RadA family of recombinase proteins, including RecA proteins of bacteria, RadAs in archaea, Rad51 and DMC1 proteins in Eukaryotes. Archaea and eukaryotes encode RadA/Rad51 paralogues, such as Rad55/57 in yeast, Rad51B/C/D, Xrcc2 and Xrcc3 in mammals, and RadB, RadC in Archaea, which facilitate homologous recombination by interacting with RadA/Rad51 recombinases. Archaeal RadA and eukaryotic Rad51 proteins show high amino acid sequence identities to each other (over 40%) but they are more distantly related to bacterial RecA proteins, exhibiting about 20% sequence identity. Archaeal and eukaryotic recombinases are also more closely related to each other at protein domain structure. RadA paralogues represent another major group of AAA + ATPases involved in DNA damage repair in Archaea
metabolism
nanobiomotors perform various important functions in the cell, and they also emerge as potential vehicle for drug delivery. The proteins employ conserved ATPase domains to convert chemical energy to mechanical work and motion. Some are active during DNA damage repair. All nanobiomotors contain an ATPase domain that adopts RecA fold structure, characteristic for RecA/RadA family proteins, structural analyses of archaeal nucleic acid biomotors and the molecular mechanisms of how ATP binding and hydrolysis promote the conformation change that drives mechanical motion
physiological function
additional information
the ring and right-handed filament structures of RadAs, domain structure and organization, overview. In the absence of ATP, the Walker motifs adopt a conformation to hold the ATP-binding site open and do not interact with the adjacent ATPase domain
physiological function
archaeal RadA proteins are close homologues of eukaryal Rad51 and DMC1 proteins and are remote homologues of bacterial RecA proteins. For the repair of double-stranded breaks in DNA, these recombinases promote a pivotal strand-exchange reaction between homologous single-stranded and double-stranded DNA substrates. This DNA-repair function also plays a key role in the resistance of cancer cells to chemotherapy and radiotherapy and in the resistance of bacterial cells to antibiotics
physiological function
play a key role in DNA repair by forming helical nucleoprotein filaments which promote a hallmark strand exchange reaction between homologous DNA substrates
physiological function
homologous recombination protein RadA/Rad51 recombinase binds to 3'-pertruding ends of dsDNA mediating the strand invasion reaction in homologous recombination. The recombinases are essential mediators of homologous recombination, an activity that is required for repairing dsDNA breaks and re-starting of stalled DNA replication forks. The RecA/RadA-facilitated strand exchange reaction occurs in two steps: (a) the recombinases bind to ssDNA, forming a nucleoprotein complex, and (b) the nucleoprotein complex invades a homologous dsDNA, such that the invading RadA-ssDNA base pairs with the complimentary strand of the dsDNA whereas the other stranded of the DNA becomes ssDNA, forming a so-called D-loop structure. The D-loop structure is a very important intermediate in DNA repair or DNA replication processes. Rotation mechanism of the enzyme nanobiomotor. RadA provides a prototype nanobiomotor for studying conversion of chemical energy to mechanical movement. In the clockwise rotation model, ATP binding and hydrolysis at the core domain result in repositioning of NTD and core domain and rotation between two adjacent subunits. Unlike most nanobiomotors that translocate along DNA, RadA polymers do not move along ssDNA or dsDNA but rotate around the axis like F1 ATPase
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UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
enzyme domain organization, structure comparisons, overview
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CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
crystal structure analysis, enzyme with bound AMP-PNP, PDB ID 1T4G
crystallization of a hexameric form of a truncated Methanococcus voltae RadA protein devoid of its small N-terminal domain, crystals are grown by the hanging drop method The RadA hexamers further assemble into two-ringed assemblies
hanging drop crystallization method at 21 °C. Enzyme in complex with AMP-PNP and K+ (2.7 A resolution), enzyme in complex with AMP-PNP (2.9 A resolution), enzyme in complex with ADP (2.4 A resolution)
hanging drop crystallization method at 21°C crystal structure of the enzyme in complex with ADP and Mg2+ at 2.1 A resolution
hanging drop crystallization method at room temperature, enzyme in complex with the ATP analog AMP-PNP at 2.0 A resolution. The RadA filament is a 106.7 A pitch helix with six subunits per turn. The DNA binding loops L1 and L2 are located in close proximity to the filament axis. The ATP analog is buried between two RadA subunits
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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
D246A
loss of binding a second Mg2+. Initial ATP turnover rate is reduced by about 20-fold
D302K
mutant protein shows comparable strand exchange efficiencies in the presence of either potassium or sodium
E151D
mutant protein retains potassium preference in promoting strand exchange. Reduced ATPase activity and normal strand exchange activity
E151K
mutant protein retains potassium preference in promoting strand exchange. Reduced ATPase activity and normal strand exchange activity
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PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
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APPLICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
pharmacology
application potential of archaeal nanobiomotors in drug delivery
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Du, L.; Luo, Y.
Structure of a hexameric form of RadA recombinase from Methanococcus voltae
Acta Crystallogr. Sect. F
68
511-516
2012
Methanococcus voltae (O73948), Methanococcus voltae
brenda
Qian, X.; Wu, Y.; He, Y.; Luo, Y.
Crystal structure of Methanococcus voltae RadA in complex with ADP: hydrolysis-induced conformational change
Biochemistry
44
13753-13761
2005
Methanococcus voltae (O73948), Methanococcus voltae
brenda
Qian, X.; He, Y.; Luo, Y.
Binding of a second magnesium is required for ATPase activity of RadA from Methanococcus voltae
Biochemistry
46
5855-5863
2007
Methanococcus voltae (O73948), Methanococcus voltae
brenda
Qian, X.; He, Y.; Wu, Y.; Luo, Y.
Asp302 determines potassium dependence of a RadA recombinase from Methanococcus voltae
J. Mol. Biol.
360
537-547
2006
Methanococcus voltae (O73948), Methanococcus voltae
brenda
Wu, Y.; He, Y.; Moya, I.A.; Qian, X.; Luo, Y.
Crystal structure of archaeal recombinase RADA: a snapshot of its extended conformation
Mol. Cell.
15
423-435
2004
Methanococcus voltae (O73948), Methanococcus voltae
brenda
Han, W.; Shen, Y.; She, Q.
Nanobiomotors of archaeal DNA repair machineries: current research status and application potential
Cell Biosci.
4
32
2014
Archaeoglobus fulgidus, Sulfolobus islandicus, Sulfurisphaera tokodaii, Methanococcus voltae (O73948), Pyrococcus furiosus (O74036), Saccharolobus solfataricus (Q55075), Thermoplasma acidophilum (Q9HJ68), Saccharolobus solfataricus P2 (Q55075), Thermoplasma acidophilum ATCC 25905 (Q9HJ68)
brenda
EXTERNAL LINKS (specific for EC-Number 3.6.4.B7)
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
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