Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Acquired Immunodeficiency Syndrome
Inclusion body myopathy-associated mutations in p97/VCP impair endoplasmic reticulum-associated degradation.
Adenocarcinoma
Increased expression of valosin-containing protein (p97) is associated with lymph node metastasis and prognosis of pancreatic ductal adenocarcinoma.
Adrenoleukodystrophy
Organelle disease: peroxisomal disorders.
Alzheimer Disease
Identification of a novel valosin-containing protein polymorphism in late-onset Alzheimer's disease.
Amyotrophic Lateral Sclerosis
A patient with familial amyotrophic lateral sclerosis associated with a new valosin-containing protein (VCP) gene mutation.
Amyotrophic Lateral Sclerosis
Altered intracellular localization and valosin-containing protein (p97 VCP) interaction underlie ATP7A-related distal motor neuropathy.
Amyotrophic Lateral Sclerosis
An autopsy report of a familial amyotrophic lateral sclerosis case carrying VCP Arg487His mutation with a unique TDP43 proteinopathy.
Amyotrophic Lateral Sclerosis
Ceramide contributes to pathogenesis and may be targeted for therapy in VCP inclusion body myopathy.
Amyotrophic Lateral Sclerosis
Characterization of the Asian myopathy patients with VCP mutations.
Amyotrophic Lateral Sclerosis
Erratum: A patient with familial amyotrophic lateral sclerosis associated with a new valosin-containing protein (VCP) gene mutation.
Amyotrophic Lateral Sclerosis
Exome sequencing reveals VCP mutations as a cause of familial ALS.
Amyotrophic Lateral Sclerosis
Immunoreactivity of valosin-containing protein in sporadic amyotrophic lateral sclerosis and in a case of its novel mutant.
Amyotrophic Lateral Sclerosis
Increased expression of valosin-containing protein in the skin of patients with amyotrophic lateral sclerosis.
Amyotrophic Lateral Sclerosis
Lipid-enriched diet rescues lethality and slows down progression in a murine model of VCP-associated disease.
Amyotrophic Lateral Sclerosis
mTOR dysfunction contributes to vacuolar pathology and weakness in valosin-containing protein associated inclusion body myopathy.
Amyotrophic Lateral Sclerosis
Mutational analysis of VCP gene in familial amyotrophic lateral sclerosis.
Amyotrophic Lateral Sclerosis
Novel valosin-containing protein mutations associated with multisystem proteinopathy.
Amyotrophic Lateral Sclerosis
Novel VCP mutations expand the mutational spectrum of frontotemporal dementia.
Amyotrophic Lateral Sclerosis
Screening of VCP mutations in Chinese amyotrophic lateral sclerosis patients.
Amyotrophic Lateral Sclerosis
SVIP is a molecular determinant of lysosomal dynamic stability, neurodegeneration and lifespan.
Amyotrophic Lateral Sclerosis
Valosin-containing protein (VCP) mutations in sporadic amyotrophic lateral sclerosis.
Amyotrophic Lateral Sclerosis
VCP mutations in familial and sporadic amyotrophic lateral sclerosis.
Amyotrophic Lateral Sclerosis
[The molecular pathology of frontotemporal lobar degeneration]
Astrocytoma
Enterovirus 71 induces neural cell apoptosis and autophagy through promoting ACOX1 downregulation and ROS generation.
Blindness
PEX1 deficiency presenting as Leber congenital amaurosis.
Breast Neoplasms
High expression of valosin-containing protein predicts poor prognosis in patients with breast carcinoma.
Breast Neoplasms
p97/VCP is highly expressed in the stem-like cells of breast cancer and controls cancer stemness partly through the unfolded protein response.
Carcinogenesis
Epigenetic loss of the endoplasmic reticulum-associated degradation inhibitor SVIP induces cancer cell metabolic reprogramming.
Carcinogenesis
Lon Peptidase 2, Peroxisomal (LONP2) Contributes to Cervical Carcinogenesis via Oxidative Stress.
Carcinogenesis
Neurotrophin 3/TrkC-regulated proteins in the human medulloblastoma cell line DAOY.
Carcinogenesis
Subcellular and functional proteomic analysis of the cellular responses induced by Helicobacter pylori.
Carcinogenesis
VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells.
Carcinoma
Expression level of valosin-containing protein (p97) is associated with prognosis of esophageal carcinoma.
Carcinoma
Expression level of valosin-containing protein (p97) is correlated with progression and prognosis of non-small-cell lung carcinoma.
Carcinoma
Expression level of valosin-containing protein (VCP) as a prognostic marker for gingival squamous cell carcinoma.
Carcinoma
Expression level of valosin-containing protein is strongly associated with progression and prognosis of gastric carcinoma.
Carcinoma
Prognostic significance of pre B cell leukemia transcription factor 2 (PBX2) expression in non-small cell lung carcinoma.
Carcinoma
Targeting valosin-containing protein enhances the efficacy of radiation therapy in esophageal squamous cell carcinoma.
Carcinoma
Valosin-containing protein (VCP/p97)-expression correlates with prognosis of HPV- negative oropharyngeal squamous cell carcinoma (OSCC).
Carcinoma, Hepatocellular
Elevated expression of valosin-containing protein (p97) in hepatocellular carcinoma is correlated with increased incidence of tumor recurrence.
Carcinoma, Non-Small-Cell Lung
Expression level of valosin-containing protein (p97) is correlated with progression and prognosis of non-small-cell lung carcinoma.
Carcinoma, Squamous Cell
Expression level of valosin-containing protein (VCP) as a prognostic marker for gingival squamous cell carcinoma.
Cardiomegaly
Novel genomic targets of valosin-containing protein in protecting pathological cardiac hypertrophy.
Cardiomyopathies
Disruption of valosin-containing protein activity causes cardiomyopathy and reveals pleiotropic functions in cardiac homeostasis.
Cataract
Variant analysis of PEX11B gene from a family with peroxisome biogenesis disorder 14B by whole exome sequencing.
Choriocarcinoma
Disruption of p97/VCP induces autophagosome accumulation, cell cycle arrest and apoptosis in human choriocarcinoma cells.
Cockayne Syndrome
Valosin-containing Protein (VCP)/p97 Segregase Mediates Proteolytic Processing of Cockayne Syndrome Group B (CSB) in Damaged Chromatin.
Colorectal Neoplasms
A covalent p97/VCP ATPase inhibitor can overcome resistance to CB-5083 and NMS-873 in colorectal cancer cells.
Colorectal Neoplasms
Expression of valosin-containing protein in colorectal carcinomas as a predictor for disease recurrence and prognosis.
Colorectal Neoplasms
Valosin-containing protein (VCP) promotes the growth, invasion, and metastasis of colorectal cancer through activation of STAT3 signaling.
Communicable Diseases
Infectious disease: Peroxin inhibitor treats Trypanosoma infection.
Congenital Abnormalities
Peroxin 5: a cycling receptor for protein translocation into peroxisomes.
Dementia
Altered intracellular localization and valosin-containing protein (p97 VCP) interaction underlie ATP7A-related distal motor neuropathy.
Dementia
Amyotrophic lateral sclerosis, frontotemporal lobar dementia, and p62: A functional convergence?
Dementia
Brain imaging and neuropsychology in late-onset dementia due to a novel mutation (R93C) of valosin-containing protein.
Dementia
Distal myopathy and rapidly progressive dementia associated with a novel mutation in the VCP gene: Expanding inclusion body myopathy with early-onset Paget disease and frontotemporal dementia spectrum.
Dementia
Identification of a novel valosin-containing protein polymorphism in late-onset Alzheimer's disease.
Dementia
Inclusion body myopathy, Paget's disease of the bone and fronto-temporal dementia: a disorder of autophagy.
Dementia
Inclusion body myopathy-associated mutations in p97/VCP impair endoplasmic reticulum-associated degradation.
Dementia
Late-onset autosomal dominant limb girdle muscular dystrophy and Paget's disease of bone unlinked to the VCP gene locus.
Dementia
Mechanisms of disease: genetics of Paget's disease of bone and related disorders.
Dementia
mTOR dysfunction contributes to vacuolar pathology and weakness in valosin-containing protein associated inclusion body myopathy.
Dementia
Mutational analysis of the VCP gene in Parkinson's disease.
Dementia
Valosin-containing protein disease: inclusion body myopathy with Paget's disease of the bone and fronto-temporal dementia.
Dementia
[An advanced case of myopathy and dementia with a new mutation in the valosin-containing protein gene].
Distal Myopathies
Distal myopathy and rapidly progressive dementia associated with a novel mutation in the VCP gene: Expanding inclusion body myopathy with early-onset Paget disease and frontotemporal dementia spectrum.
Encephalitis, Japanese
Valosin-containing protein/p97 plays critical roles in the Japanese encephalitis virus life cycle.
Esophageal Squamous Cell Carcinoma
Targeting valosin-containing protein enhances the efficacy of radiation therapy in esophageal squamous cell carcinoma.
Fetal Growth Retardation
Peroxisome Deficiency Dysregulates Fatty Acid Oxidization and Exacerbates Lipotoxicity in ? Cells.
Frontotemporal Dementia
A cross-sectional analysis of clinical evaluation in 35 individuals with mutations of the valosin-containing protein gene.
Frontotemporal Dementia
A novel exon 2 I27V VCP variant is associated with dissimilar clinical syndromes.
Frontotemporal Dementia
A novel mutation in the VCP gene (G157R) in a German family with inclusion-body myopathy with Paget disease of bone and frontotemporal dementia.
Frontotemporal Dementia
A progressive translational mouse model of human valosin-containing protein disease: the VCP(R155H/+) mouse.
Frontotemporal Dementia
A unique IBMPFD-related P97/VCP mutation with differential binding pattern and subcellular localization.
Frontotemporal Dementia
Altered cofactor regulation with disease-associated p97/VCP mutations.
Frontotemporal Dementia
An Italian family with inclusion-body myopathy and frontotemporal dementia due to mutation in the VCP gene.
Frontotemporal Dementia
Another VCP interactor: NF is enough.
Frontotemporal Dementia
APOE is a potential modifier gene in an autosomal dominant form of frontotemporal dementia (IBMPFD).
Frontotemporal Dementia
ATP-bound form of the D1 AAA domain inhibits an essential function of Cdc48p/p97.
Frontotemporal Dementia
Axonal hyperpolarization in inclusion-body myopathy, Paget disease of the bone, and frontotemporal dementia (IBMPFD).
Frontotemporal Dementia
Brain imaging and neuropsychology in late-onset dementia due to a novel mutation (R93C) of valosin-containing protein.
Frontotemporal Dementia
Ceramide contributes to pathogenesis and may be targeted for therapy in VCP inclusion body myopathy.
Frontotemporal Dementia
Characterization of the Asian myopathy patients with VCP mutations.
Frontotemporal Dementia
Clinical outcome in 19 French and Spanish patients with valosin-containing protein myopathy associated with Paget's disease of bone and frontotemporal dementia.
Frontotemporal Dementia
Distinct distal myopathy phenotype caused by VCP gene mutation in a Finnish family.
Frontotemporal Dementia
Early-onset Alzheimers and Cortical Vision Impairment in a Woman With Valosin-containing Protein Disease Associated With 2 APOE [Latin Small Letter Open E]4/APOE [Latin Small Letter Open E]4 Genotype.
Frontotemporal Dementia
Etiologic factors in Paget's disease of bone.
Frontotemporal Dementia
Global Gene Expression Profiling in R155H Knock-In Murine Model of VCP Disease.
Frontotemporal Dementia
Global gene profiling of VCP-associated inclusion body myopathy.
Frontotemporal Dementia
Hereditary inclusion body myopathy-linked p97/VCP mutations in the NH2 domain and the D1 ring modulate p97/VCP ATPase activity and D2 ring conformation.
Frontotemporal Dementia
Immunoreactivity of valosin-containing protein in sporadic amyotrophic lateral sclerosis and in a case of its novel mutant.
Frontotemporal Dementia
Impaired protein aggregate handling and clearance underlie the pathogenesis of p97/VCP-associated disease.
Frontotemporal Dementia
Inclusion body myopathy and frontotemporal dementia caused by a novel VCP mutation.
Frontotemporal Dementia
Inclusion body myopathy and Paget disease is linked to a novel mutation in the VCP gene.
Frontotemporal Dementia
Inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia is caused by mutant valosin-containing protein.
Frontotemporal Dementia
Inclusion Body Myopathy With Paget Disease of Bone and Frontotemporal Dementia Linked to VCP p.Arg155Cys in a Korean Family.
Frontotemporal Dementia
Involvement of peripheral and central nervous systems in a valosin-containing protein mutation.
Frontotemporal Dementia
Juvenile Paget's disease, familial expansile osteolysis and other genetic osteolytic disorders.
Frontotemporal Dementia
Lipid-enriched diet rescues lethality and slows down progression in a murine model of VCP-associated disease.
Frontotemporal Dementia
Multisystem proteinopathy: Where myopathy and motor neuron disease converge.
Frontotemporal Dementia
Mutant valosin-containing protein causes a novel type of frontotemporal dementia.
Frontotemporal Dementia
Mutational analysis of VCP gene in familial amyotrophic lateral sclerosis.
Frontotemporal Dementia
Neuronal-specific overexpression of a mutant valosin-containing protein associated with IBMPFD promotes aberrant ubiquitin and TDP-43 accumulation and cognitive dysfunction in transgenic mice.
Frontotemporal Dementia
Novel ubiquitin neuropathology in frontotemporal dementia with valosin-containing protein gene mutations.
Frontotemporal Dementia
Novel valosin-containing protein mutations associated with multisystem proteinopathy.
Frontotemporal Dementia
Novel VCP mutations expand the mutational spectrum of frontotemporal dementia.
Frontotemporal Dementia
Novel VCP mutations in inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia.
Frontotemporal Dementia
Nuclear inclusions mimicking poly(A)-binding protein nuclear 1 inclusions in a case of inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia with a novel mutation in the valosin-containing protein gene.
Frontotemporal Dementia
Nuclear localization of valosin-containing protein in normal muscle and muscle affected by inclusion-body myositis.
Frontotemporal Dementia
Pathogenic VCP/TER94 alleles are dominant actives and contribute to neurodegeneration by altering cellular ATP level in a Drosophila IBMPFD model.
Frontotemporal Dementia
Pathological consequences of VCP mutations on human striated muscle.
Frontotemporal Dementia
Phenotypic diversity in an international Cure VCP Disease registry.
Frontotemporal Dementia
Phenotypic variability in three families with valosin-containing protein mutation.
Frontotemporal Dementia
Psychiatric Presentation of Frontotemporal Dementia Associated with Inclusion Body Myopathy due to the VCP Mutation (R155H) in a French Family.
Frontotemporal Dementia
Radiological features of Paget disease of bone associated with VCP myopathy.
Frontotemporal Dementia
Slow development of ALS-like spinal cord pathology in mutant valosin-containing protein gene knock-in mice.
Frontotemporal Dementia
Structural and functional deviations in disease-associated p97 mutants.
Frontotemporal Dementia
Strumpellin is a novel valosin-containing protein binding partner linking hereditary spastic paraplegia to protein aggregation diseases.
Frontotemporal Dementia
Targeted Excision of VCP R155H Mutation by Cre-LoxP Technology as a Promising Therapeutic Strategy for Valosin-Containing Protein Disease.
Frontotemporal Dementia
TDP-43 in Familial and Sporadic Frontotemporal Lobar Degeneration with Ubiquitin Inclusions.
Frontotemporal Dementia
TDP-43 in familial and sporadic frontotemporal lobar degeneration with ubiquitin inclusions.
Frontotemporal Dementia
TDP-43 in the ubiquitin pathology of frontotemporal dementia with VCP gene mutations.
Frontotemporal Dementia
TDP-43 mediates degeneration in a novel Drosophila model of disease caused by mutations in VCP/p97.
Frontotemporal Dementia
The Myoblast C2C12 Transfected with Mutant Valosin-Containing Protein Exhibits Delayed Stress Granule Resolution on Oxidative Stress.
Frontotemporal Dementia
Transgenic expression of inclusion body myopathy associated mutant p97/VCP causes weakness and ubiquitinated protein inclusions in mice.
Frontotemporal Dementia
Transgenic mice expressing mutant forms VCP/p97 recapitulate the full spectrum of IBMPFD including degeneration in muscle, brain and bone.
Frontotemporal Dementia
Valosin-containing protein (VCP) is a novel IQ motif-containing GTPase activating protein 1 (IQGAP1)-interacting protein.
Frontotemporal Dementia
Valosin-containing protein (VCP) is required for autophagy and is disrupted in VCP disease.
Frontotemporal Dementia
Valosin-containing protein and the pathogenesis of frontotemporal dementia associated with inclusion body myopathy.
Frontotemporal Dementia
VCP gene analyses in Japanese patients with sporadic amyotrophic lateral sclerosis identify a new mutation.
Frontotemporal Dementia
[A case of inclusion body myopathy with Paget's disease of bone and frontotemporal dementia (IBMPFD) showing clinical features of motor neuron disease].
Frontotemporal Dementia
[Inclusion body myositis, Paget's disease of the bone and frontotemporal dementia: early involvement of the heart and respiratory muscles].
Frontotemporal Dementia
[Multilocular Paget's disease in IBMPFD syndrome. A case report with 14-year follow-up].
Frontotemporal Dementia
[The molecular pathology of frontotemporal lobar degeneration]
Frontotemporal Lobar Degeneration
ALS and FTLD: two faces of TDP-43 proteinopathy.
Frontotemporal Lobar Degeneration
Amyotrophic lateral sclerosis, frontotemporal lobar dementia, and p62: A functional convergence?
Frontotemporal Lobar Degeneration
Clinic, neuropathology and molecular genetics of frontotemporal dementia: a mini-review.
Frontotemporal Lobar Degeneration
Clinical heterogeneity in 3 unrelated families linked to VCP p.Arg159His.
Frontotemporal Lobar Degeneration
Frontotemporal dementias: update on recent developments in molecular genetics and neuropathology.
Frontotemporal Lobar Degeneration
Recent advances in the genetics of the ALS-FTLD complex.
Frontotemporal Lobar Degeneration
The molecular genetics and neuropathology of frontotemporal lobar degeneration: recent developments.
Frontotemporal Lobar Degeneration
[Frontotemporal dementia (FTD) and genetic mutations including progranulin gene]
Frontotemporal Lobar Degeneration
[The molecular pathology of frontotemporal lobar degeneration]
Genetic Diseases, Inborn
Slow development of ALS-like spinal cord pathology in mutant valosin-containing protein gene knock-in mice.
Glaucoma
Effect of VCP modulators on gene expression profiles of retinal ganglion cells in an acute injury mouse model.
Glaucoma
Valosin-Containing Protein is a Novel Autoantigen in Patients with Glaucoma.
Glioblastoma
Retinoid receptor turnover mediated by sumoylation, ubiquitination and the valosin-containing protein is disrupted in glioblastoma.
Glioma
Valosin-containing protein regulates the proteasome-mediated degradation of DNA-PKcs in glioma cells.
Hearing Loss
Variant analysis of PEX11B gene from a family with peroxisome biogenesis disorder 14B by whole exome sequencing.
Hepatitis B
Hepatitis B virus X protein enhances activation of nuclear factor ?B through interaction with valosin-containing protein.
Hepatitis C
Affinity purification of the Hepatitis C virus replicase identifies Valosin-containing protein (VCP) AAA+ATPase as an active viral replication modulator.
Hepatitis C
Aggregation of a hepatitis C virus replicase module induced by ablation of p97/VCP.
Huntington Disease
Enhanced ATPase activities as a primary defect of mutant valosin-containing proteins that cause inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia.
Infections
Colletotrichum orbiculare FAM1 Encodes a Novel Woronin Body-Associated Pex22 Peroxin Required for Appressorium-Mediated Plant Infection.
Infections
Enterovirus 71 induces neural cell apoptosis and autophagy through promoting ACOX1 downregulation and ROS generation.
Infections
Genome-Wide Screen Reveals Valosin-Containing Protein Requirement for Coronavirus Exit from Endosomes.
Infections
Infectious disease: Peroxin inhibitor treats Trypanosoma infection.
Infections
MrPEX33 is involved in infection-related morphogenesis and pathogenicity of Metarhizium robertsii.
Intellectual Disability
Variant analysis of PEX11B gene from a family with peroxisome biogenesis disorder 14B by whole exome sequencing.
Ischemic Stroke
KUS121, a valosin-containing protein modulator, attenuates ischemic stroke via preventing ATP depletion.
Leber Congenital Amaurosis
PEX1 deficiency presenting as Leber congenital amaurosis.
Leishmaniasis
Down-regulation of peroxin synthesis by silencing RNA (siRNA): A novel hypothesis for treatment of leishmaniasis.
Leukemia
Prognostic significance of pre B cell leukemia transcription factor 2 (PBX2) expression in non-small cell lung carcinoma.
Leukemia, Myeloid, Acute
Targeting acute myeloid leukemia dependency on VCP-mediated DNA repair through a selective second-generation small-molecule inhibitor.
Leukemia, T-Cell
What's in the Literature?
Liposarcoma
Monocytes of patients with amyotrophic lateral sclerosis linked to gene mutations display altered TDP-43 subcellular distribution.
Liver Cirrhosis, Biliary
Autoantibodies from primary biliary cirrhosis patients with anti-p95c antibodies bind to recombinant p97/VCP and inhibit in vitro nuclear envelope assembly.
Liver Neoplasms
Sorafenib-mediated targeting of the AAA? ATPase p97/VCP leads to disruption of the secretory pathway, endoplasmic reticulum stress, and hepatocellular cancer cell death.
Lymphatic Metastasis
Increased expression of valosin-containing protein (p97) is associated with lymph node metastasis and prognosis of pancreatic ductal adenocarcinoma.
Lymphatic Metastasis
Lon Peptidase 2, Peroxisomal (LONP2) Contributes to Cervical Carcinogenesis via Oxidative Stress.
Lymphoma
Expression level of valosin containing protein is associated with prognosis of primary orbital MALT lymphoma.
Lymphoma
In vitro efficacy of a first-generation valosin-containing protein inhibitor (CB-5083) against canine lymphoma.
Lymphoma, B-Cell
Upregulation of valosin-containing protein (VCP) is associated with poor prognosis and promotes tumor progression of orbital B-cell lymphoma.
Machado-Joseph Disease
Enhanced ATPase activities as a primary defect of mutant valosin-containing proteins that cause inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia.
Melanoma
Exposure to Melan-A/MART-126-35 tumor epitope specific CD8(+)T cells reveals immune escape by affecting the ubiquitin-proteasome system (UPS).
Motor Neuron Disease
Altered intracellular localization and valosin-containing protein (p97 VCP) interaction underlie ATP7A-related distal motor neuropathy.
Motor Neuron Disease
ATP7A trafficking and mechanisms underlying the distal motor neuropathy induced by mutations in ATP7A.
Motor Neuron Disease
Phosphorylation of S409/410 of TDP-43 is a consistent feature in all sporadic and familial forms of TDP-43 proteinopathies.
Multiple Myeloma
Novel p97/VCP inhibitor induces endoplasmic reticulum stress and apoptosis in both bortezomib-sensitive and -resistant multiple myeloma cells.
Muscle Weakness
Global Gene Expression Profiling in R155H Knock-In Murine Model of VCP Disease.
Muscular Atrophy
The p97/VCP ATPase is critical in muscle atrophy and the accelerated degradation of muscle proteins.
Muscular Diseases
A cross-sectional analysis of clinical evaluation in 35 individuals with mutations of the valosin-containing protein gene.
Muscular Diseases
A novel mutation in the VCP gene (G157R) in a German family with inclusion-body myopathy with Paget disease of bone and frontotemporal dementia.
Muscular Diseases
A progressive translational mouse model of human valosin-containing protein disease: the VCP(R155H/+) mouse.
Muscular Diseases
A unique IBMPFD-related P97/VCP mutation with differential binding pattern and subcellular localization.
Muscular Diseases
Activation of the NLRP3 Inflammasome Is Associated with Valosin-Containing Protein Myopathy.
Muscular Diseases
Altered cofactor regulation with disease-associated p97/VCP mutations.
Muscular Diseases
Altered intracellular localization and valosin-containing protein (p97 VCP) interaction underlie ATP7A-related distal motor neuropathy.
Muscular Diseases
An Italian family with inclusion-body myopathy and frontotemporal dementia due to mutation in the VCP gene.
Muscular Diseases
Another VCP interactor: NF is enough.
Muscular Diseases
APOE is a potential modifier gene in an autosomal dominant form of frontotemporal dementia (IBMPFD).
Muscular Diseases
ATP-bound form of the D1 AAA domain inhibits an essential function of Cdc48p/p97.
Muscular Diseases
Axonal hyperpolarization in inclusion-body myopathy, Paget disease of the bone, and frontotemporal dementia (IBMPFD).
Muscular Diseases
Brain imaging and neuropsychology in late-onset dementia due to a novel mutation (R93C) of valosin-containing protein.
Muscular Diseases
Ceramide contributes to pathogenesis and may be targeted for therapy in VCP inclusion body myopathy.
Muscular Diseases
Characterization of the Asian myopathy patients with VCP mutations.
Muscular Diseases
Clinical heterogeneity in 3 unrelated families linked to VCP p.Arg159His.
Muscular Diseases
Clinical outcome in 19 French and Spanish patients with valosin-containing protein myopathy associated with Paget's disease of bone and frontotemporal dementia.
Muscular Diseases
Crucial mitochondrial impairment upon CDC48 mutation in apoptotic yeast.
Muscular Diseases
Distal myopathy and rapidly progressive dementia associated with a novel mutation in the VCP gene: Expanding inclusion body myopathy with early-onset Paget disease and frontotemporal dementia spectrum.
Muscular Diseases
Distinct distal myopathy phenotype caused by VCP gene mutation in a Finnish family.
Muscular Diseases
Early-onset Alzheimers and Cortical Vision Impairment in a Woman With Valosin-containing Protein Disease Associated With 2 APOE [Latin Small Letter Open E]4/APOE [Latin Small Letter Open E]4 Genotype.
Muscular Diseases
Etiologic factors in Paget's disease of bone.
Muscular Diseases
Global Gene Expression Profiling in R155H Knock-In Murine Model of VCP Disease.
Muscular Diseases
Global gene profiling of VCP-associated inclusion body myopathy.
Muscular Diseases
Hereditary inclusion body myopathy-linked p97/VCP mutations in the NH2 domain and the D1 ring modulate p97/VCP ATPase activity and D2 ring conformation.
Muscular Diseases
Immunoreactivity of valosin-containing protein in sporadic amyotrophic lateral sclerosis and in a case of its novel mutant.
Muscular Diseases
Impaired protein aggregate handling and clearance underlie the pathogenesis of p97/VCP-associated disease.
Muscular Diseases
Inclusion body myopathy and frontotemporal dementia caused by a novel VCP mutation.
Muscular Diseases
Inclusion body myopathy and Paget disease is linked to a novel mutation in the VCP gene.
Muscular Diseases
Inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia is caused by mutant valosin-containing protein.
Muscular Diseases
Inclusion Body Myopathy With Paget Disease of Bone and Frontotemporal Dementia Linked to VCP p.Arg155Cys in a Korean Family.
Muscular Diseases
Inclusion body myopathy, Paget's disease of the bone and fronto-temporal dementia: a disorder of autophagy.
Muscular Diseases
Inclusion body myopathy-associated mutations in p97/VCP impair endoplasmic reticulum-associated degradation.
Muscular Diseases
Involvement of peripheral and central nervous systems in a valosin-containing protein mutation.
Muscular Diseases
Juvenile Paget's disease, familial expansile osteolysis and other genetic osteolytic disorders.
Muscular Diseases
Lipid-enriched diet rescues lethality and slows down progression in a murine model of VCP-associated disease.
Muscular Diseases
Mechanisms of disease: genetics of Paget's disease of bone and related disorders.
Muscular Diseases
Mitochondrial Respiratory Measurements in Patient-derived Fibroblasts.
Muscular Diseases
mTOR dysfunction contributes to vacuolar pathology and weakness in valosin-containing protein associated inclusion body myopathy.
Muscular Diseases
Multisystem proteinopathy: Where myopathy and motor neuron disease converge.
Muscular Diseases
Mutant valosin-containing protein causes a novel type of frontotemporal dementia.
Muscular Diseases
Mutational analysis of VCP gene in familial amyotrophic lateral sclerosis.
Muscular Diseases
Neuronal-specific overexpression of a mutant valosin-containing protein associated with IBMPFD promotes aberrant ubiquitin and TDP-43 accumulation and cognitive dysfunction in transgenic mice.
Muscular Diseases
Novel ubiquitin neuropathology in frontotemporal dementia with valosin-containing protein gene mutations.
Muscular Diseases
Novel valosin-containing protein mutations associated with multisystem proteinopathy.
Muscular Diseases
Novel VCP mutations expand the mutational spectrum of frontotemporal dementia.
Muscular Diseases
Novel VCP mutations in inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia.
Muscular Diseases
Nuclear inclusions mimicking poly(A)-binding protein nuclear 1 inclusions in a case of inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia with a novel mutation in the valosin-containing protein gene.
Muscular Diseases
Nuclear localization of valosin-containing protein in normal muscle and muscle affected by inclusion-body myositis.
Muscular Diseases
Pathogenic VCP/TER94 alleles are dominant actives and contribute to neurodegeneration by altering cellular ATP level in a Drosophila IBMPFD model.
Muscular Diseases
Pathological consequences of VCP mutations on human striated muscle.
Muscular Diseases
Phenotypic diversity in an international Cure VCP Disease registry.
Muscular Diseases
Phenotypic variability in three families with valosin-containing protein mutation.
Muscular Diseases
Psychiatric Presentation of Frontotemporal Dementia Associated with Inclusion Body Myopathy due to the VCP Mutation (R155H) in a French Family.
Muscular Diseases
Radiological features of Paget disease of bone associated with VCP myopathy.
Muscular Diseases
Slow development of ALS-like spinal cord pathology in mutant valosin-containing protein gene knock-in mice.
Muscular Diseases
Structural and functional deviations in disease-associated p97 mutants.
Muscular Diseases
Strumpellin is a novel valosin-containing protein binding partner linking hereditary spastic paraplegia to protein aggregation diseases.
Muscular Diseases
Targeted Excision of VCP R155H Mutation by Cre-LoxP Technology as a Promising Therapeutic Strategy for Valosin-Containing Protein Disease.
Muscular Diseases
Targeting protein homeostasis in sporadic inclusion body myositis.
Muscular Diseases
TDP-43 in the ubiquitin pathology of frontotemporal dementia with VCP gene mutations.
Muscular Diseases
TDP-43 mediates degeneration in a novel Drosophila model of disease caused by mutations in VCP/p97.
Muscular Diseases
The Myoblast C2C12 Transfected with Mutant Valosin-Containing Protein Exhibits Delayed Stress Granule Resolution on Oxidative Stress.
Muscular Diseases
Transgenic expression of inclusion body myopathy associated mutant p97/VCP causes weakness and ubiquitinated protein inclusions in mice.
Muscular Diseases
Transgenic mice expressing mutant forms VCP/p97 recapitulate the full spectrum of IBMPFD including degeneration in muscle, brain and bone.
Muscular Diseases
Translocation of molecular chaperones to the titin springs is common in skeletal myopathy patients and affects sarcomere function.
Muscular Diseases
Valosin-containing protein (VCP) is a novel IQ motif-containing GTPase activating protein 1 (IQGAP1)-interacting protein.
Muscular Diseases
Valosin-containing protein (VCP) is required for autophagy and is disrupted in VCP disease.
Muscular Diseases
Valosin-containing protein and the pathogenesis of frontotemporal dementia associated with inclusion body myopathy.
Muscular Diseases
Valosin-containing protein disease: inclusion body myopathy with Paget's disease of the bone and fronto-temporal dementia.
Muscular Diseases
VCP gene analyses in Japanese patients with sporadic amyotrophic lateral sclerosis identify a new mutation.
Muscular Diseases
[A case of inclusion body myopathy with Paget's disease of bone and frontotemporal dementia (IBMPFD) showing clinical features of motor neuron disease].
Muscular Diseases
[An advanced case of myopathy and dementia with a new mutation in the valosin-containing protein gene].
Muscular Diseases
[Multilocular Paget's disease in IBMPFD syndrome. A case report with 14-year follow-up].
Muscular Dystrophies
Late-onset autosomal dominant limb girdle muscular dystrophy and Paget's disease of bone unlinked to the VCP gene locus.
Muscular Dystrophies
SVIP is a molecular determinant of lysosomal dynamic stability, neurodegeneration and lifespan.
Muscular Dystrophy, Duchenne
Translocation of molecular chaperones to the titin springs is common in skeletal myopathy patients and affects sarcomere function.
Myositis
A novel exon 2 I27V VCP variant is associated with dissimilar clinical syndromes.
Myositis
Nuclear localization of valosin-containing protein in normal muscle and muscle affected by inclusion-body myositis.
Myositis
Translocation of molecular chaperones to the titin springs is common in skeletal myopathy patients and affects sarcomere function.
Myositis
What's in the Literature?
Myositis
[Inclusion body myositis, Paget's disease of the bone and frontotemporal dementia: early involvement of the heart and respiratory muscles].
Myositis, Inclusion Body
A novel exon 2 I27V VCP variant is associated with dissimilar clinical syndromes.
Myositis, Inclusion Body
Translocation of molecular chaperones to the titin springs is common in skeletal myopathy patients and affects sarcomere function.
Myositis, Inclusion Body
What's in the Literature?
Myositis, Inclusion Body
[Inclusion body myositis, Paget's disease of the bone and frontotemporal dementia: early involvement of the heart and respiratory muscles].
Neoplasm Metastasis
Demethylation-mediated miR-129-5p up-regulation inhibits malignant phenotype of osteogenic osteosarcoma by targeting Homo sapiens valosin-containing protein (VCP).
Neoplasm Metastasis
E74-like factor 2 regulates valosin-containing protein expression.
Neoplasm Metastasis
Elevated expression of valosin-containing protein (p97) in hepatocellular carcinoma is correlated with increased incidence of tumor recurrence.
Neoplasm Metastasis
Elevated expression of valosin-containing protein (p97) is associated with poor prognosis of prostate cancer.
Neoplasm Metastasis
Expression level of valosin-containing protein (p97) is associated with prognosis of esophageal carcinoma.
Neoplasm Metastasis
Expression level of valosin-containing protein (p97) is correlated with progression and prognosis of non-small-cell lung carcinoma.
Neoplasm Metastasis
Expression level of valosin-containing protein (VCP) as a prognostic marker for gingival squamous cell carcinoma.
Neoplasm Metastasis
Expression level of valosin-containing protein is strongly associated with progression and prognosis of gastric carcinoma.
Neoplasm Metastasis
Expression of valosin-containing protein in colorectal carcinomas as a predictor for disease recurrence and prognosis.
Neoplasm Metastasis
Identification and characterization of valosin-containing protein (VCP/p97) in untransformed osteoblast-like cells.
Neoplasm Metastasis
Increased expression of valosin-containing protein (p97) is associated with lymph node metastasis and prognosis of pancreatic ductal adenocarcinoma.
Neoplasm Metastasis
Inhibiting valosin-containing protein suppresses osteosarcoma cell metastasis via AKT/nuclear factor of kappa B signaling pathway in vitro.
Neoplasm Metastasis
Lon Peptidase 2, Peroxisomal (LONP2) Contributes to Cervical Carcinogenesis via Oxidative Stress.
Neoplasm Metastasis
Prognostic significance of pre B cell leukemia transcription factor 2 (PBX2) expression in non-small cell lung carcinoma.
Neoplasm Metastasis
Valosin-containing protein (VCP) promotes the growth, invasion, and metastasis of colorectal cancer through activation of STAT3 signaling.
Neoplasm Metastasis
Valosin-containing protein promotes metastasis of osteosarcoma through autophagy induction and anoikis inhibition via the ERK/NF-??/beclin-1 signaling pathway.
Neoplasms
A Dynamic molecular basis for malfunction in disease mutants of p97/VCP.
Neoplasms
A novel function of AAA-ATPase p97/VCP in the regulation of cell motility.
Neoplasms
A p97/Valosin-Containing Protein Inhibitor Drug CB-5083 Has a Potent but Reversible Off-Target Effect on Phosphodiesterase-6.
Neoplasms
Allosteric p97 inhibitors can overcome resistance to ATP-competitive p97 inhibitors for potential anti-cancer therapy.
Neoplasms
ATPase activity of p97/valosin-containing protein is regulated by oxidative modification of the evolutionally conserved cysteine 522 residue in Walker A motif.
Neoplasms
Crystal structure of human FAF1 UBX domain reveals a novel FcisP touch-turn motif in p97/VCP-binding region.
Neoplasms
Disruption of p97/VCP induces autophagosome accumulation, cell cycle arrest and apoptosis in human choriocarcinoma cells.
Neoplasms
E74-like factor 2 regulates valosin-containing protein expression.
Neoplasms
E74-like factor 2 transactivates valosin-containing protein gene, a gene involved in cancer growth.
Neoplasms
Eeyarestatin I derivatives with improved aqueous solubility.
Neoplasms
Elevated expression of valosin-containing protein (p97) in hepatocellular carcinoma is correlated with increased incidence of tumor recurrence.
Neoplasms
Elevated expression of valosin-containing protein (p97) is associated with poor prognosis of prostate cancer.
Neoplasms
Genetic prognostic index influences patient outcome for node-positive breast cancer.
Neoplasms
In vitro efficacy of a first-generation valosin-containing protein inhibitor (CB-5083) against canine lymphoma.
Neoplasms
Inadequate fine-tuning of protein synthesis and failure of amino acid homeostasis following inhibition of the ATPase VCP/p97.
Neoplasms
Increased expression of valosin-containing protein (p97) is correlated with disease recurrence in follicular thyroid cancer.
Neoplasms
Inhibiting valosin-containing protein suppresses osteosarcoma cell metastasis via AKT/nuclear factor of kappa B signaling pathway in vitro.
Neoplasms
Inhibitors of the AAA+ Chaperone p97.
Neoplasms
Novel p97/VCP inhibitor induces endoplasmic reticulum stress and apoptosis in both bortezomib-sensitive and -resistant multiple myeloma cells.
Neoplasms
p97/VCP is highly expressed in the stem-like cells of breast cancer and controls cancer stemness partly through the unfolded protein response.
Neoplasms
Point-of-care test for cervical cancer in LMICs.
Neoplasms
Pre-B-cell leukemia transcription factor 1 regulates expression of valosin-containing protein, a gene involved in cancer growth.
Neoplasms
Prognostic significance of pre B cell leukemia transcription factor 2 (PBX2) expression in non-small cell lung carcinoma.
Neoplasms
Protein kinase A inhibition facilitates the antitumor activity of xanthohumol, a valosin-containing protein inhibitor.
Neoplasms
Proteotoxic crisis, the ubiquitin-proteasome system, and cancer therapy.
Neoplasms
Synthesis and In Vitro Evaluation of 2-[3-(2-Aminoethyl)-1H-indol-1-yl]-N-benzylquinazolin-4-amine as a Novel p97/VCP Inhibitor Lead Capable of Inducing Apoptosis in Cancer Cells.
Neoplasms
Targeting the NPL4 Adaptor of p97/VCP Segregase by Disulfiram as an Emerging Cancer Vulnerability Evokes Replication Stress and DNA Damage while Silencing the ATR Pathway.
Neoplasms
Targeting valosin-containing protein enhances the efficacy of radiation therapy in esophageal squamous cell carcinoma.
Neoplasms
The p97-UFD1L-NPL4 protein complex mediates cytokine-induced I?B? proteolysis.
Neoplasms
Tumor Suppressor RARRES1 Regulates DLG2, PP2A, VCP, EB1, and Ankrd26.
Neoplasms
Ubiquitin proteasome system and autophagy associated proteins in human testicular tumors.
Neoplasms
Upregulation of valosin-containing protein (VCP) is associated with poor prognosis and promotes tumor progression of orbital B-cell lymphoma.
Neoplasms
Valosin-containing protein (p97) and Ki-67 expression is a useful marker in detecting malignant behavior of pancreatic endocrine neoplasms.
Neoplasms
Valosin-containing protein (VCP/p97)-expression correlates with prognosis of HPV- negative oropharyngeal squamous cell carcinoma (OSCC).
Neoplasms
Valosin-containing protein cleavage by granzyme K accelerates an endoplasmic reticulum stress leading to caspase-independent cytotoxicity of target tumor cells.
Neoplasms
Valosin-containing Protein in Psoriasis: A Clinical and Immunohistochemical Study.
Neoplasms
Valosin-containing Protein is a Target of 5'-l Fuligocandin?B and Enhances TRAIL Resistance in Cancer Cells.
Nervous System Diseases
Mutational analysis of the VCP gene in Parkinson's disease.
Neuroblastoma
Enterovirus 71 induces neural cell apoptosis and autophagy through promoting ACOX1 downregulation and ROS generation.
Neurodegenerative Diseases
Drosophila Valosin-Containing Protein is required for dendrite pruning through a regulatory role in mRNA metabolism.
Neurodegenerative Diseases
Functional ATPase activity of p97/valosin-containing protein (VCP) is required for the quality control of endoplasmic reticulum in neuronally differentiated mammalian PC12 cells.
Neurodegenerative Diseases
Increased expression of valosin-containing protein in the skin of patients with amyotrophic lateral sclerosis.
Neurodegenerative Diseases
Lysine methylation of VCP by a member of a novel human protein methyltransferase family.
Neurodegenerative Diseases
Neuronal remodeling and apoptosis require VCP-dependent degradation of the apoptosis inhibitor DIAP1.
Neurodegenerative Diseases
Next Generation Sequencing and ALS: known genes, different phenotyphes.
Neurodegenerative Diseases
Phosphorylation of S409/410 of TDP-43 is a consistent feature in all sporadic and familial forms of TDP-43 proteinopathies.
Neurodegenerative Diseases
Physical and functional interaction between Dorfin and Valosin-containing protein that are colocalized in ubiquitylated inclusions in neurodegenerative disorders.
Neurodegenerative Diseases
Rare variants in SQSTM1 and VCP genes and risk of sporadic inclusion body myositis.
Neurodegenerative Diseases
The wide-ranging clinical and genetic features in Japanese families with valosin-containing protein proteinopathy.
Neurodegenerative Diseases
Valosin-containing protein (VCP) in novel feedback machinery between abnormal protein accumulation and transcriptional suppression.
Osteitis Deformans
A novel exon 2 I27V VCP variant is associated with dissimilar clinical syndromes.
Osteitis Deformans
A novel mutation in the VCP gene (G157R) in a German family with inclusion-body myopathy with Paget disease of bone and frontotemporal dementia.
Osteitis Deformans
A progressive translational mouse model of human valosin-containing protein disease: the VCP(R155H/+) mouse.
Osteitis Deformans
Altered cofactor regulation with disease-associated p97/VCP mutations.
Osteitis Deformans
An Italian family with inclusion-body myopathy and frontotemporal dementia due to mutation in the VCP gene.
Osteitis Deformans
APOE is a potential modifier gene in an autosomal dominant form of frontotemporal dementia (IBMPFD).
Osteitis Deformans
Brain imaging and neuropsychology in late-onset dementia due to a novel mutation (R93C) of valosin-containing protein.
Osteitis Deformans
Ceramide contributes to pathogenesis and may be targeted for therapy in VCP inclusion body myopathy.
Osteitis Deformans
Characterization of the Asian myopathy patients with VCP mutations.
Osteitis Deformans
Clinical heterogeneity in 3 unrelated families linked to VCP p.Arg159His.
Osteitis Deformans
Clinical outcome in 19 French and Spanish patients with valosin-containing protein myopathy associated with Paget's disease of bone and frontotemporal dementia.
Osteitis Deformans
Early-onset Alzheimers and Cortical Vision Impairment in a Woman With Valosin-containing Protein Disease Associated With 2 APOE [Latin Small Letter Open E]4/APOE [Latin Small Letter Open E]4 Genotype.
Osteitis Deformans
Etiologic factors in Paget's disease of bone.
Osteitis Deformans
Evaluation of the role of Valosin-containing protein in the pathogenesis of familial and sporadic Paget's disease of bone.
Osteitis Deformans
Global Gene Expression Profiling in R155H Knock-In Murine Model of VCP Disease.
Osteitis Deformans
Global gene profiling of VCP-associated inclusion body myopathy.
Osteitis Deformans
Hereditary inclusion body myopathy-linked p97/VCP mutations in the NH2 domain and the D1 ring modulate p97/VCP ATPase activity and D2 ring conformation.
Osteitis Deformans
Identification and characterization of valosin-containing protein (VCP/p97) in untransformed osteoblast-like cells.
Osteitis Deformans
Inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia is caused by mutant valosin-containing protein.
Osteitis Deformans
Inclusion Body Myopathy With Paget Disease of Bone and Frontotemporal Dementia Linked to VCP p.Arg155Cys in a Korean Family.
Osteitis Deformans
Late-onset autosomal dominant limb girdle muscular dystrophy and Paget's disease of bone unlinked to the VCP gene locus.
Osteitis Deformans
Lipid-enriched diet rescues lethality and slows down progression in a murine model of VCP-associated disease.
Osteitis Deformans
Multisystem proteinopathy: Where myopathy and motor neuron disease converge.
Osteitis Deformans
Neuronal-specific overexpression of a mutant valosin-containing protein associated with IBMPFD promotes aberrant ubiquitin and TDP-43 accumulation and cognitive dysfunction in transgenic mice.
Osteitis Deformans
Novel ubiquitin neuropathology in frontotemporal dementia with valosin-containing protein gene mutations.
Osteitis Deformans
Novel valosin-containing protein mutations associated with multisystem proteinopathy.
Osteitis Deformans
Novel VCP mutations expand the mutational spectrum of frontotemporal dementia.
Osteitis Deformans
Novel VCP mutations in inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia.
Osteitis Deformans
Nuclear inclusions mimicking poly(A)-binding protein nuclear 1 inclusions in a case of inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia with a novel mutation in the valosin-containing protein gene.
Osteitis Deformans
Pathogenic VCP/TER94 alleles are dominant actives and contribute to neurodegeneration by altering cellular ATP level in a Drosophila IBMPFD model.
Osteitis Deformans
Phenotypic diversity in an international Cure VCP Disease registry.
Osteitis Deformans
Radiological features of Paget disease of bone associated with VCP myopathy.
Osteitis Deformans
Slow development of ALS-like spinal cord pathology in mutant valosin-containing protein gene knock-in mice.
Osteitis Deformans
SQSTM1 mutations in Han Chinese populations with sporadic amyotrophic lateral sclerosis.
Osteitis Deformans
Strumpellin is a novel valosin-containing protein binding partner linking hereditary spastic paraplegia to protein aggregation diseases.
Osteitis Deformans
TDP-43 in the ubiquitin pathology of frontotemporal dementia with VCP gene mutations.
Osteitis Deformans
TDP-43 mediates degeneration in a novel Drosophila model of disease caused by mutations in VCP/p97.
Osteitis Deformans
Transgenic expression of inclusion body myopathy associated mutant p97/VCP causes weakness and ubiquitinated protein inclusions in mice.
Osteitis Deformans
Transgenic mice expressing mutant forms VCP/p97 recapitulate the full spectrum of IBMPFD including degeneration in muscle, brain and bone.
Osteitis Deformans
Valosin-containing protein (VCP) is a novel IQ motif-containing GTPase activating protein 1 (IQGAP1)-interacting protein.
Osteitis Deformans
Valosin-containing protein and the pathogenesis of frontotemporal dementia associated with inclusion body myopathy.
Osteitis Deformans
[A case of inclusion body myopathy with Paget's disease of bone and frontotemporal dementia (IBMPFD) showing clinical features of motor neuron disease].
Osteosarcoma
Demethylation-mediated miR-129-5p up-regulation inhibits malignant phenotype of osteogenic osteosarcoma by targeting Homo sapiens valosin-containing protein (VCP).
Osteosarcoma
Identification and characterization of valosin-containing protein (VCP/p97) in untransformed osteoblast-like cells.
Osteosarcoma
Inhibiting valosin-containing protein suppresses osteosarcoma cell metastasis via AKT/nuclear factor of kappa B signaling pathway in vitro.
Osteosarcoma
Knockdown of Aurora-B alters osteosarcoma cell malignant phenotype via decreasing phosphorylation of VCP and NF-?B signaling.
Osteosarcoma
Paget's Disease of Bone: Evidence for Complex Pathogenetic Interactions.
Osteosarcoma
Valosin-containing protein promotes metastasis of osteosarcoma through autophagy induction and anoikis inhibition via the ERK/NF-??/beclin-1 signaling pathway.
Pancreatic Neoplasms
Valosin-Containing Protein Stabilizes Mutant p53 to Promote Pancreatic Cancer Growth.
Paraplegia
Novel spastin (SPG4) mutations in Italian patients with hereditary spastic paraplegia.
Paraplegia
Spastin mutations are frequent in sporadic spastic paraparesis and their spectrum is different from that observed in familial cases.
Paraplegia
Spastin, a new AAA protein, is altered in the most frequent form of autosomal dominant spastic paraplegia.
Paraplegia
SPG7 targets the m-AAA protease complex to process MCU for uniporter assembly, Ca2+ influx, and regulation of mitochondrial permeability transition pore opening.
Parkinson Disease
Enhanced ATPase activities as a primary defect of mutant valosin-containing proteins that cause inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia.
Parkinson Disease
SVIP is a molecular determinant of lysosomal dynamic stability, neurodegeneration and lifespan.
Parkinson Disease
Valosin-containing protein mutation and Parkinson's disease.
Parkinsonian Disorders
Parkinsonian syndrome in familial frontotemporal dementia.
Parkinsonian Disorders
Parkinsonism in a patient with valosin-containing protein gene mutation showing: a case report.
Perinatal Death
Peroxisomal protein PEX13 functions in selective autophagy.
Pituitary Neoplasms
Modified cell cycle status in a mouse model of altered neuronal vulnerability (slow Wallerian degeneration; Wlds).
Polyneuropathies
Variant analysis of PEX11B gene from a family with peroxisome biogenesis disorder 14B by whole exome sequencing.
Pre-Eclampsia
Altered expression of p97/Valosin containing protein and impaired autophagy in preeclamptic human placenta.
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
Pre-B-cell leukemia transcription factor 1 regulates expression of valosin-containing protein, a gene involved in cancer growth.
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
Prognostic significance of pre B cell leukemia transcription factor 2 (PBX2) expression in non-small cell lung carcinoma.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Bortezomib Treatment can Overcome Glucocorticoid Resistance in Childhood B-cell Precursor Acute Lymphoblastic Leukemia Cell Lines.
Prostatic Neoplasms
Chemistry and biology for the small molecules targeting characteristics of cancer cells.
Prostatic Neoplasms
Elevated expression of valosin-containing protein (p97) is associated with poor prognosis of prostate cancer.
Prostatic Neoplasms
Interleukin-6 induced overexpression of valosin-containing protein (VCP)/p97 is associated with androgen-independent prostate cancer (AIPC) progression.
Psoriasis
Valosin-containing Protein in Psoriasis: A Clinical and Immunohistochemical Study.
Pulmonary Disease, Chronic Obstructive
Critical role of proteostasis-imbalance in pathogenesis of COPD and severe emphysema.
Refsum Disease
Phenotype of adult Refsum disease due to a defect in peroxin 7.
Retinal Degeneration
Expression of p97/VCP and ubiquitin during postnatal development of the degenerating rat retina.
Retinal Diseases
Modulation of valosin-containing protein by Kyoto University Substances (KUS) as a novel therapeutic strategy for ischemic neuronal diseases.
Retinitis Pigmentosa
Efficient Ocular Delivery of VCP siRNA via Reverse Magnetofection in RHO P23H Rodent Retina Explants.
Rift Valley Fever
Sorafenib impedes Rift Valley fever virus egress by inhibiting Valosin-containing protein function in the cellular secretory pathway.
Sarcoma
Amyotrophic lateral sclerosis, frontotemporal lobar dementia, and p62: A functional convergence?
Sarcoma
Frontotemporal dementia: from mendelian genetics towards genome wide association studies.
Sarcoma
Frontotemporal dementia: implications for understanding Alzheimer disease.
Sarcoma
Genetics of Alzheimer's Disease and Frontotemporal Dementia.
Sarcoma
Parkinsonian syndrome in familial frontotemporal dementia.
Sarcoma
Phenotypic Heterogeneity of Monogenic Frontotemporal Dementia.
Seizures
PEX1 deficiency presenting as Leber congenital amaurosis.
Spastic Paraplegia, Hereditary
Hereditary Spastic Paraplegia with a Novel SPAST Mutation Misdiagnosed with Subacute Combined Degeneration.
Spastic Paraplegia, Hereditary
Strumpellin is a novel valosin-containing protein binding partner linking hereditary spastic paraplegia to protein aggregation diseases.
Squamous Cell Carcinoma of Head and Neck
Valosin-containing protein (VCP/p97)-expression correlates with prognosis of HPV- negative oropharyngeal squamous cell carcinoma (OSCC).
Starvation
The peroxin Pex14p is involved in LC3-dependent degradation of mammalian peroxisomes.
Stomach Diseases
Subcellular and functional proteomic analysis of the cellular responses induced by Helicobacter pylori.
Synucleinopathies
Valosin-containing protein immunoreactivity in tauopathies, synucleinopathies, polyglutamine diseases and intranuclear inclusion body disease.
Tauopathies
Valosin-containing protein immunoreactivity in tauopathies, synucleinopathies, polyglutamine diseases and intranuclear inclusion body disease.
TDP-43 Proteinopathies
ALS and FTLD: two faces of TDP-43 proteinopathy.
TDP-43 Proteinopathies
Frontotemporal dementias: update on recent developments in molecular genetics and neuropathology.
TDP-43 Proteinopathies
TDP-43 in neurodegenerative disorders.
Testicular Neoplasms
Ubiquitin proteasome system and autophagy associated proteins in human testicular tumors.
Thyroid Neoplasms
Increased expression of valosin-containing protein (p97) is correlated with disease recurrence in follicular thyroid cancer.
Uterine Cervical Neoplasms
Lon Peptidase 2, Peroxisomal (LONP2) Contributes to Cervical Carcinogenesis via Oxidative Stress.
Werner Syndrome
Werner syndrome protein directly binds to the AAA ATPase p97/VCP in an ATP-dependent fashion.
Wiskott-Aldrich Syndrome
Genetic analysis of VCP and WASH complex genes in a German cohort of sporadic ALS-FTD patients.
Yellow Fever
A Sensitive Yellow Fever Virus Entry Reporter Identifies Valosin-Containing Protein (VCP/p97) as an Essential Host Factor for Flavivirus Uncoating.
Zellweger Syndrome
A cytoplasmic AAA family peroxin, Pex1p, interacts with Pex6p.
Zellweger Syndrome
Drosophila carrying pex3 or pex16 mutations are models of zellweger syndrome that reflect its symptoms associated with the absence of peroxisomes.
Zellweger Syndrome
Genetic and clinical aspects of Zellweger spectrum patients with PEX1 mutations.
Zellweger Syndrome
Human peroxisome assembly factor-2 (PAF-2): a gene responsible for group C peroxisome biogenesis disorder in humans.
Zellweger Syndrome
Organelle disease: peroxisomal disorders.
Zellweger Syndrome
Peroxisomal protein PEX13 functions in selective autophagy.
Zellweger Syndrome
Peroxisome biogenesis and molecular defects in peroxisome assembly disorders.
Zellweger Syndrome
The membrane biogenesis peroxin Pex16p. Topogenesis and functional roles in peroxisomal membrane assembly.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
3.6.4.7 peroxisome-assembly ATPase
more
top
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). 
