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Information on EC 3.6.4.6 - vesicle-fusing ATPase and Organism(s) Saccharolobus solfataricus and UniProt Accession Q97ZJ7

for references in articles please use BRENDA:EC3.6.4.6
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IUBMB Comments
A large family of ATP-hydrolysing enzymes involved in the heterotypic fusion of membrane vesicles with target membranes and the homotypic fusion of various membrane compartments. They belong to the AAA-type (_A_TPase _a_ssociated with a variety of cell _a_ctivities) ATPase superfamily. They include peroxin, which apparently is involved in Zellweger's syndrome.
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Saccharolobus solfataricus
UNIPROT: Q97ZJ7
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Word Map
The taxonomic range for the selected organisms is: Saccharolobus solfataricus
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Reaction Schemes
Synonyms
n-ethylmaleimide-sensitive factor, cdc48, aaa-atpase, n-ethylmaleimide-sensitive fusion protein, atp6v0d2, n-ethylmaleimide sensitive factor, sec18p, sec18, cdc48p, pex1p, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
vacuolar protein sorting 4
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N-ethylmaleimide sensitive fusion protein
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-
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NEM-sensitive fusion protein
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-
-
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SKD2 protein
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-
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Vesicular-fusion protein NSF
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of phosphoric ester
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-
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SYSTEMATIC NAME
IUBMB Comments
ATP phosphohydrolase (vesicle-fusing)
A large family of ATP-hydrolysing enzymes involved in the heterotypic fusion of membrane vesicles with target membranes and the homotypic fusion of various membrane compartments. They belong to the AAA-type (_A_TPase _a_ssociated with a variety of cell _a_ctivities) ATPase superfamily. They include peroxin, which apparently is involved in Zellweger's syndrome.
CAS REGISTRY NUMBER
COMMENTARY hide
9000-83-3
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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
the enzyme provides energy for the ESCRT (endosomal sorting complexes required for transport) pathway
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
42248
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
dimer
2 * 42248, calculated from sequence, the enzyme rapidly interconverts between multiple oligomeric states, it interconverts between dimers and hexamers in the presence of adenosine nucleotides
hexamer
6 * 42248, calculated from sequence, the enzyme rapidly interconverts between multiple oligomeric states, it interconverts between dimers and hexamers in the presence of adenosine nucleotides
CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
sitting-drop vapor diffusion at 20°C
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expression in Escherichia coli
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Monroe, N.; Han, H.; M.D., Gonciarz; Eckert, D.M.; Karren, M.A.; Whitby, F.G.; Sundquist, W.I.; Hill, C.P.
The oligomeric state of the active Vps4 AAA ATPase
J. Mol. Biol.
426
510-525
2013
Saccharomyces cerevisiae, Saccharolobus solfataricus (Q97ZJ7), Saccharolobus solfataricus, Saccharolobus solfataricus P2 (Q97ZJ7)
Manually annotated by BRENDA team