Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Adenocarcinoma
A Pilot Evaluation of a Novel Immunohistochemical Assay for Topoisomerase II-alpha and Minichromosome Maintenance Protein 2 Expression (ProEx C) in Cervical Adenocarcinoma In Situ, Adenocarcinoma, and Benign Glandular Mimics.
Adenocarcinoma
Clinicopathologic significance of minichromosome maintenance protein 2 and Tat-interacting protein 30 expression in benign and malignant lesions of the gallbladder.
Adenocarcinoma
Genome-wide association study of familial lung cancer.
Adenocarcinoma
MiR-362-3p functions as a tumor suppressor through targeting MCM5 in cervical adenocarcinoma.
Adenocarcinoma
Recurrent amplification of RTEL1 and ABCA13 and its synergistic effect associated with clinicopathological data of gastric adenocarcinoma.
Adenocarcinoma
Significant effect of homologous recombination DNA repair gene polymorphisms on pancreatic cancer survival.
Adenocarcinoma
Surface expression of minichromosome maintenance proteins provides a novel method for detecting patients at risk for developing adenocarcinoma in Barrett's esophagus.
Adenocarcinoma
Systematic cytological evaluation and immunocytochemistry of minichromosome maintenance protein 2 and p53 significantly improve cytological diagnosis of pancreaticobiliary adenocarcinoma.
Adenocarcinoma
Therapeutic radiation induces different changes in expression profiles of metallothionein (MT) mRNA, MT protein, Ki 67 and minichromosome maintenance protein 3 in human rectal adenocarcinoma.
Adenocarcinoma
Werner's syndrome as a hereditary risk factor for exocrine pancreatic cancer: Potential role of WRN in pancreatic tumorigenesis and patient-tailored therapy.
Adenocarcinoma
[Expression of minichromosome maintenance protein 2 in colonic adenocarcinoma, adenoma and normal colonic mucosa and its clinical significance]
Adenocarcinoma in Situ
A Pilot Evaluation of a Novel Immunohistochemical Assay for Topoisomerase II-alpha and Minichromosome Maintenance Protein 2 Expression (ProEx C) in Cervical Adenocarcinoma In Situ, Adenocarcinoma, and Benign Glandular Mimics.
Adenocarcinoma of Lung
MCM2 and Ki-67 expression in human lung adenocarcinoma: prognostic implications.
Adenoma
Cell proliferation marker MCM2, but not Ki67, is helpful for distinguishing between minimally invasive follicular carcinoma and follicular adenoma of the thyroid.
Adenoma
Protein kinase A subunit expression is altered in Bloom syndrome fibroblasts and the BLM protein is increased in adrenocortical hyperplasias: inverse findings for BLM and PRKAR1A.
Adenoma
[Expression of minichromosome maintenance protein 2 in colonic adenocarcinoma, adenoma and normal colonic mucosa and its clinical significance]
Agammaglobulinemia
Novel biallelic TRNT1 mutations resulting in sideroblastic anemia, combined B and T cell defects, hypogammaglobulinemia, recurrent infections, hypertrophic cardiomyopathy and developmental delay.
alpha-Thalassemia
A point mutation in the XNP gene, associated with an ATR-X phenotype without alpha-thalassemia.
Alzheimer Disease
A novel variation in the Twinkle linker region causing late-onset dementia.
Alzheimer Disease
Borrowing nuclear DNA helicases to protect mitochondrial DNA.
Alzheimer Disease
FE65 regulates and interacts with the Bloom syndrome protein in dynamic nuclear spheres - potential relevance to Alzheimer's disease.
Anemia
BRCA1-mediated repression of mutagenic end-joining of DNA double-strand breaks requires complex formation with BACH1.
Anemia
Crosstalk between BRCA-Fanconi anemia and mismatch repair pathways prevents MSH2-dependent aberrant DNA damage responses.
Anemia
FANCJ helicase defective in Fanconia anemia and breast cancer unwinds G-quadruplex DNA to defend genomic stability.
Anemia
Identification of the NLS and NES motifs of VP2 from chicken anemia virus and the interaction of VP2 with mini-chromosome maintenance protein 3.
Anemia
Structure, function and evolution of the XPD family of iron-sulfur-containing 5'-->3' DNA helicases.
Anemia, Aplastic
Genetic features of myelodysplastic syndrome and aplastic anemia in pediatric and young adult patients.
Anemia, Aplastic
Mutant mice lacking the p53 C-terminal domain model telomere syndromes.
Anemia, Sideroblastic
Mutations in TRNT1 cause congenital sideroblastic anemia with immunodeficiency, fevers, and developmental delay (SIFD).
Anemia, Sideroblastic
Novel biallelic TRNT1 mutations resulting in sideroblastic anemia, combined B and T cell defects, hypogammaglobulinemia, recurrent infections, hypertrophic cardiomyopathy and developmental delay.
Anthrax
An essential DnaB helicase of Bacillus anthracis: identification, characterization, and mechanism of action.
Astrocytoma
Analysis of difference of association between polymorphisms in the XRCC5, RPA3 and RTEL1 genes and glioma, astrocytoma and glioblastoma.
Astrocytoma
CCDC26, CDKN2BAS, RTEL1 and TERT Polymorphisms in pediatric brain tumor susceptibility.
Astrocytoma
Expression and clinical significance of the proliferation marker minichromosome maintenance protein 2 (Mcm2) in diffuse astrocytomas WHO grade II.
Astrocytoma
Immunohistochemical evaluation of minichromosome maintenance protein 7 in astrocytoma grading.
Astrocytoma
Minichromosome maintenance protein 3 elicits a cancer-restricted immune response in patients with brain malignancies and is a strong independent predictor of survival in patients with anaplastic astrocytoma.
Astrocytoma
New insights into susceptibility to glioma.
Astrocytoma
RTEL1 and TERT polymorphisms are associated with astrocytoma risk in the Chinese Han population.
Astrocytoma
RTEL1: functions of a disease-associated helicase.
Ataxia
Molecular analysis of ANT1, TWINKLE and POLG in patients with multiple deletions or depletion of mitochondrial DNA by a dHPLC-based assay.
Ataxia
Mutation in TWINKLE in a Large Iranian Family with Progressive External Ophthalmoplegia, Myopathy, Dysphagia and Dysphonia, and Behavior Change.
Ataxia
SANDO: Two novel mutations in POLG1 gene.
Ataxia Telangiectasia
Ataxia-Telangiectasia and RAD3-Related and Ataxia-Telangiectasia-Mutated Proteins in Epithelial Ovarian Carcinoma: Their Expression and Clinical Significance.
Ataxia Telangiectasia
Emergence of a DNA-damage response network consisting of Fanconi anaemia and BRCA proteins.
Ataxia Telangiectasia
Oxidative stress in Fanconi anaemia: from cells and molecules towards prospects in clinical management.
Ataxia Telangiectasia
RECQ1 helicase is involved in replication stress survival and drug resistance in multiple myeloma.
Ataxia Telangiectasia
The interaction between checkpoint kinase 1 (Chk1) and the minichromosome maintenance (MCM) complex is required for DNA damage-induced Chk1 phosphorylation.
Atherosclerosis
Liver Aging and Pseudocapillarization in a Werner Syndrome Mouse Model.
Azoospermia
Polymorphism of the GRTH/DDX25 gene in normal and infertile Japanese men: a missense mutation associated with loss of GRTH phosphorylation.
Barrett Esophagus
Surface expression of minichromosome maintenance proteins provides a novel method for detecting patients at risk for developing adenocarcinoma in Barrett's esophagus.
Blepharoptosis
Orthostatic Tremor, Progressive External Ophthalmoplegia, and Twinkle.
Bloom Syndrome
A major role for mitotic CDC2 kinase inactivation in the establishment of the mitotic DNA damage checkpoint.
Bloom Syndrome
A novel frameshift mutation in BLM gene associated with high sister chromatid exchanges (SCE) in heterozygous family members.
Bloom Syndrome
A positive involvement of RecQL4 in UV-induced S-phase arrest.
Bloom Syndrome
A role for PML and the nuclear body in genomic stability.
Bloom Syndrome
A small molecule inhibitor of the BLM helicase modulates chromosome stability in human cells.
Bloom Syndrome
Aberrant BLM cytoplasmic expression associates with DNA damage stress and hypersensitivity to DNA-damaging agents in colorectal cancer.
Bloom Syndrome
Aberrant chromosome morphology in human cells defective for Holliday junction resolution.
Bloom Syndrome
Association of the Bloom syndrome protein with topoisomerase IIIalpha in somatic and meiotic cells.
Bloom Syndrome
ATM-dependent phosphorylation and accumulation of endogenous BLM protein in response to ionizing radiation.
Bloom Syndrome
Binding specificity determines polarity of DNA unwinding by the Sgs1 protein of S. cerevisiae.
Bloom Syndrome
BLM helicase facilitates Mus81 endonuclease activity in human cells.
Bloom Syndrome
BLM promotes the activation of Fanconi Anemia signaling pathway.
Bloom Syndrome
BLM unfolds G-quadruplexes in different structural environments through different mechanisms.
Bloom Syndrome
BLM's balancing act and the involvement of FANCJ in DNA repair.
Bloom Syndrome
BLM, the Bloom's syndrome protein, varies during the cell cycle in its amount, distribution, and co-localization with other nuclear proteins.
Bloom Syndrome
Bloom DNA helicase facilitates homologous recombination between diverged homologous sequences.
Bloom Syndrome
Bloom syndrome and Fanconi's anemia: rate and ethnic origin of mutation carriers in Israel.
Bloom Syndrome
Bloom syndrome ortholog HIM-6 maintains genomic stability in C. elegans.
Bloom Syndrome
Bloom's syndrome protein response to ultraviolet-C radiation and hydroxyurea-mediated DNA synthesis inhibition.
Bloom Syndrome
Bloom's Syndrome: Clinical Spectrum, Molecular Pathogenesis, and Cancer Predisposition.
Bloom Syndrome
Cell cycle regulation of the endogenous wild type Bloom's syndrome DNA helicase.
Bloom Syndrome
Cellular defects caused by hypomorphic variants of the Bloom syndrome helicase gene BLM.
Bloom Syndrome
Characterization and mutational analysis of the RecQ core of the bloom syndrome protein.
Bloom Syndrome
Characterization of a new BLM mutation associated with a topoisomerase II alpha defect in a patient with Bloom's syndrome.
Bloom Syndrome
Characterization of the nuclear localization signal in the DNA helicase responsible for Bloom syndrome.
Bloom Syndrome
Chromosome breakage syndromes and cancer.
Bloom Syndrome
Clinical features of Bloom syndrome and function of the causative gene, BLM helicase.
Bloom Syndrome
Complex activities of the human Bloom's syndrome helicase are encoded in a core region comprising the RecA and Zn-binding domains.
Bloom Syndrome
Conserved helicase domain of human RecQ4 is required for strand annealing-independent DNA unwinding.
Bloom Syndrome
Covalent modification of the Werner's syndrome gene product with the ubiquitin-related protein, SUMO-1.
Bloom Syndrome
Critical interaction domains between bloom syndrome protein and RAD51.
Bloom Syndrome
Deficiency of bloom syndrome helicase activity is radiomimetic.
Bloom Syndrome
Defining the roles of the N-terminal region and the helicase activity of RECQ4A in DNA repair and homologous recombination in Arabidopsis.
Bloom Syndrome
Dephosphorylation and subcellular compartment change of the mitotic Bloom's syndrome DNA helicase in response to ionizing radiation.
Bloom Syndrome
DNA End Resection: Facts and Mechanisms.
Bloom Syndrome
DNA2-An Important Player in DNA Damage Response or Just Another DNA Maintenance Protein?
Bloom Syndrome
Does BLM helicase unwind nucleosomal DNA?
Bloom Syndrome
Drosophila BLM in double-strand break repair by synthesis-dependent strand annealing.
Bloom Syndrome
Elevation of sister chromatid exchange in Saccharomyces cerevisiae sgs1 disruptants and the relevance of the disruptants as a system to evaluate mutations in Bloom's syndrome gene.
Bloom Syndrome
Emergence of a DNA-damage response network consisting of Fanconi anaemia and BRCA proteins.
Bloom Syndrome
FancJ (Brip1) loss-of-function allele results in spermatogonial cell depletion during embryogenesis and altered processing of crossover sites during meiotic prophase I in mice.
Bloom Syndrome
FE65 regulates and interacts with the Bloom syndrome protein in dynamic nuclear spheres - potential relevance to Alzheimer's disease.
Bloom Syndrome
Formation of deletions during double-strand break repair in Drosophila DmBlm mutants occurs after strand invasion.
Bloom Syndrome
Functional interaction of p53 and BLM DNA helicase in apoptosis.
Bloom Syndrome
Genetic Manipulation of Homologous Recombination In Vivo Attenuates Intestinal Tumorigenesis.
Bloom Syndrome
Genetic mapping of species differences via in vitro crosses in mouse embryonic stem cells.
Bloom Syndrome
hRAD54 gene and 1p high-resolution deletion-mapping analyses in oligodendrogliomas.
Bloom Syndrome
In vivo analysis of Drosophila BLM helicase function during DNA double-strand gap repair.
Bloom Syndrome
Inhibition of unwinding of G-quadruplex structures by Sgs1 helicase in the presence of N,N'-bis[2-(1-piperidino)ethyl]-3,4,9,10-perylenetetracarboxylic diimide, a G-quadruplex-interactive ligand.
Bloom Syndrome
Interaction of replication protein A with two acidic peptides from human Bloom syndrome protein.
Bloom Syndrome
Interhomolog recombination and loss of heterozygosity in wild-type and Bloom syndrome helicase (BLM)-deficient mammalian cells.
Bloom Syndrome
Intra-nuclear trafficking of the BLM helicase to DNA damage-induced foci is regulated by SUMO modification.
Bloom Syndrome
Loss of Bloom syndrome protein destabilizes human gene cluster architecture.
Bloom Syndrome
Microhomology-mediated End Joining and Homologous Recombination share the initial end resection step to repair DNA double-strand breaks in mammalian cells.
Bloom Syndrome
miR-522-3p promotes tumorigenesis in human colorectal cancer via targeting bloom syndrome protein.
Bloom Syndrome
Multifaceted role of the Topo III?-RMI1-RMI2 complex and DNA2 in the BLM-dependent pathway of DNA break end resection.
Bloom Syndrome
Multiple functions of Drosophila BLM helicase in maintenance of genome stability.
Bloom Syndrome
Multiple genetic pathways involving the Caenorhabditis elegans Bloom's syndrome genes him-6, rad-51, and top-3 are needed to maintain genome stability in the germ line.
Bloom Syndrome
NMR Investigation of the Interaction between the RecQ C-Terminal Domain of Human Bloom Syndrome Protein and G-Quadruplex DNA from the Human c-Myc Promoter.
Bloom Syndrome
Non-Bloom syndrome-associated partial and total loss-of-function variants of BLM helicase.
Bloom Syndrome
Novel pro- and anti-recombination activities of the Bloom's syndrome helicase.
Bloom Syndrome
Nucleolar localization of the Werner syndrome protein in human cells.
Bloom Syndrome
PML is critical for ND10 formation and recruits the PML-interacting protein daxx to this nuclear structure when modified by SUMO-1.
Bloom Syndrome
Point mutations causing Bloom's syndrome abolish ATPase and DNA helicase activities of the BLM protein.
Bloom Syndrome
Possible anti-recombinogenic role of Bloom's syndrome helicase in double-strand break processing.
Bloom Syndrome
Protein kinase A subunit expression is altered in Bloom syndrome fibroblasts and the BLM protein is increased in adrenocortical hyperplasias: inverse findings for BLM and PRKAR1A.
Bloom Syndrome
Purification of overexpressed hexahistidine-tagged BLM N431 as oligomeric complexes.
Bloom Syndrome
Pyrimidine pool imbalance induced by BLM helicase deficiency contributes to genetic instability in Bloom syndrome.
Bloom Syndrome
Recombination-mediated lengthening of terminal telomeric repeats requires the Sgs1 DNA helicase.
Bloom Syndrome
RECQ DNA helicases and osteosarcoma.
Bloom Syndrome
RecQ helicase BLM regulates prostate cancer cell proliferation and apoptosis.
Bloom Syndrome
RecQ helicases: guardian angels of the DNA replication fork.
Bloom Syndrome
RECQ-like helicases Sgs1 and BLM regulate R-loop-associated genome instability.
Bloom Syndrome
Redundancy of DNA helicases in p53-mediated apoptosis.
Bloom Syndrome
Regulation and localization of the Bloom syndrome protein in response to DNA damage.
Bloom Syndrome
Regulation of homologous integration in yeast by the DNA repair proteins Ku70 and RecQ.
Bloom Syndrome
Relationships between putative G-quadruplex-forming sequences, RecQ helicases, and transcription.
Bloom Syndrome
Removal of the Bloom Syndrome DNA Helicase Extends the Utility of Imprecise Transposon Excision for Making Null Mutations in Drosophila.
Bloom Syndrome
Replication protein A physically interacts with the Bloom's syndrome protein and stimulates its helicase activity.
Bloom Syndrome
Requirement of yeast SGS1 and SRS2 genes for replication and transcription.
Bloom Syndrome
RMI, a new OB-fold complex essential for Bloom syndrome protein to maintain genome stability.
Bloom Syndrome
RMI1 contributes to DNA repair and to the tolerance to camptothecin.
Bloom Syndrome
Role of the BLM helicase in replication fork management.
Bloom Syndrome
Roles of Werner syndrome protein in protection of genome integrity.
Bloom Syndrome
Rothmund-Thomson syndrome due to RECQ4 helicase mutations: report and clinical and molecular comparisons with Bloom syndrome and Werner syndrome.
Bloom Syndrome
Rothmund-thomson syndrome responsible gene, RECQL4: genomic structure and products.
Bloom Syndrome
Selective cleavage of BLM, the bloom syndrome protein, during apoptotic cell death.
Bloom Syndrome
Small scale genetic alterations contribute to increased mutability at the X-linked Hprt locus in vivo in Blm hypomorphic mice.
Bloom Syndrome
Small Ubiquitin-related Modifier (SUMO) Binding Determines Substrate Recognition and Paralog-selective SUMO Modification.
Bloom Syndrome
Solution structure of the HRDC domain of human Bloom syndrome protein BLM.
Bloom Syndrome
Solution structure of the RecQ C-terminal domain of human Bloom syndrome protein.
Bloom Syndrome
Somatic hypermutation of immunoglobulin genes is independent of the Bloom's syndrome DNA helicase.
Bloom Syndrome
Structural and functional analyses of disease-causing missense mutations in Bloom syndrome protein.
Bloom Syndrome
Structural and functional characterization of the N-terminal domain of human Rad51D.
Bloom Syndrome
Structural basis of Bloom syndrome (BS) causing mutations in the BLM helicase domain.
Bloom Syndrome
Structural mechanisms of human RecQ helicases WRN and BLM.
Bloom Syndrome
Structure and function of the regulatory HRDC domain from human Bloom syndrome protein.
Bloom Syndrome
Structure of the RecQ C-terminal domain of human Bloom syndrome protein.
Bloom Syndrome
Syndrome-causing mutations of the BLM gene in persons in the Bloom's Syndrome Registry.
Bloom Syndrome
System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel SUMO target proteins and acceptor lysines relevant for genome stability.
Bloom Syndrome
Telomere and ribosomal DNA repeats are chromosomal targets of the bloom syndrome DNA helicase.
Bloom Syndrome
Telomere-binding protein TRF2 binds to and stimulates the Werner and Bloom syndrome helicases.
Bloom Syndrome
The arginine finger of the Bloom syndrome protein: its structural organization and its role in energy coupling.
Bloom Syndrome
The Bloom Syndrome Protein BLM Is Selectively Cleaved during Apoptotic Cell Death.
Bloom Syndrome
The Bloom syndrome protein interacts and cooperates with p53 in regulation of transcription and cell growth control.
Bloom Syndrome
The Bloom syndrome protein limits the lethality associated with RAD51 deficiency.
Bloom Syndrome
The Bloom's syndrome gene product is a 3'-5' DNA helicase.
Bloom Syndrome
The Bloom's syndrome helicase (BLM) interacts physically and functionally with p12, the smallest subunit of human DNA polymerase delta.
Bloom Syndrome
The Bloom's syndrome helicase is critical for development and function of the alphabeta T-cell lineage.
Bloom Syndrome
The Bloom's syndrome helicase promotes the annealing of complementary single-stranded DNA.
Bloom Syndrome
The Bloom's syndrome helicase suppresses crossing over during homologous recombination.
Bloom Syndrome
The Bloom's syndrome helicase unwinds G4 DNA.
Bloom Syndrome
The C-terminal domain of the Bloom syndrome DNA helicase is essential for genomic stability.
Bloom Syndrome
The contribution of the S-phase checkpoint genes MEC1 and SGS1 to genome stability maintenance in Candida albicans.
Bloom Syndrome
The DNA helicase activity of BLM is necessary for the correction of the genomic instability of bloom syndrome cells.
Bloom Syndrome
The fission yeast BLM homolog Rqh1 promotes meiotic recombination.
Bloom Syndrome
The human Bloom syndrome gene suppresses the DNA replication and repair defects of yeast dna2 mutants.
Bloom Syndrome
The human WRN and BLM RecQ helicases differentially regulate cell proliferation and survival after chemotherapeutic DNA damage.
Bloom Syndrome
The N-terminal internal region of BLM is required for the formation of dots/rod-like structures which are associated with SUMO-1.
Bloom Syndrome
The nuclease FAN1 is involved in DNA crosslink repair in Arabidopsis thaliana independently of the nuclease MUS81.
Bloom Syndrome
The Nucleo-cytoplasmic actin-binding protein CapG lacks a nuclear export sequence present in structurally related proteins.
Bloom Syndrome
The Werner syndrome protein is distinguished from the Bloom syndrome protein by its capacity to tightly bind diverse DNA structures.
Bloom Syndrome
The Werner syndrome RECQ helicase targets G4 DNA in human cells to modulate transcription.
Bloom Syndrome
Visualization of human Bloom's syndrome helicase molecules bound to homologous recombination intermediates.
Bloom Syndrome
Werner's syndrome protein (WRN) migrates Holliday junctions and co-localizes with RPA upon replication arrest.
Bloom Syndrome
Yeast as a model system to study RecQ helicase function.
Bone Marrow Diseases
FANCJ helicase defective in Fanconia anemia and breast cancer unwinds G-quadruplex DNA to defend genomic stability.
Bowen's Disease
Expression of Minichromosome Maintenance Proteins in Actinic Keratosis and Squamous Cell Carcinoma.
Brain Diseases
Abnormal Glycosylation Profile and High Alpha-Fetoprotein in a Patient with Twinkle Variants.
Brain Diseases
Recessive twinkle mutations cause severe epileptic encephalopathy.
Brain Diseases
Recessive Twinkle mutations in early onset encephalopathy with mtDNA depletion.
Brain Diseases
Twinkle-Associated Mitochondrial DNA Depletion.
Brain Neoplasms
CCDC26, CDKN2BAS, RTEL1 and TERT Polymorphisms in pediatric brain tumor susceptibility.
Brain Neoplasms
Genetic risk variants in the CDKN2A/B, RTEL1 and EGFR genes are associated with somatic biomarkers in glioma.
Breast Neoplasms
A novel breast cancer-associated BRIP1 (FANCJ/BACH1) germ-line mutation impairs protein stability and function.
Breast Neoplasms
A polymorphism in Werner syndrome gene is associated with breast cancer susceptibility in Chinese women.
Breast Neoplasms
Aberrant recombination and repair during immunoglobulin class switching in BRCA1-deficient human B cells.
Breast Neoplasms
Activation of BRCA1/BRCA2-associated helicase BACH1 is required for timely progression through S phase.
Breast Neoplasms
Analysis of the DNA substrate specificity of the human BACH1 helicase associated with breast cancer.
Breast Neoplasms
Assessing the link between BACH1 and BRCA1 in the FA pathway.
Breast Neoplasms
Assessing the link between BACH1/FANCJ and MLH1 in DNA crosslink repair.
Breast Neoplasms
Association of breast cancer risk with genetic variants showing differential allelic expression: Identification of a novel breast cancer susceptibility locus at 4q21.
Breast Neoplasms
BRIP1 inhibits the tumorigenic properties of cervical cancer by regulating RhoA GTPase activity.
Breast Neoplasms
Camptothecin targets WRN protein: mechanism and relevance in clinical breast cancer.
Breast Neoplasms
Catalytic strand separation by RECQ1 is required for RPA-mediated response to replication stress.
Breast Neoplasms
Clinical implications of germline mutations in breast cancer genes: RECQL.
Breast Neoplasms
Correlation of the BACH1 Pro919Ser polymorphism with breast cancer risk: A literature-based meta-analysis and meta-regression analysis.
Breast Neoplasms
Disease-causing missense mutations in human DNA helicase disorders.
Breast Neoplasms
DNA helicases associated with genetic instability, cancer, and aging.
Breast Neoplasms
Embryonic stem cells deficient for Brca2 or Blm exhibit divergent genotoxic profiles that support opposing activities during homologous recombination.
Breast Neoplasms
Emergence of a DNA-damage response network consisting of Fanconi anaemia and BRCA proteins.
Breast Neoplasms
FancJ (Brip1) loss-of-function allele results in spermatogonial cell depletion during embryogenesis and altered processing of crossover sites during meiotic prophase I in mice.
Breast Neoplasms
FANCJ helicase defective in Fanconia anemia and breast cancer unwinds G-quadruplex DNA to defend genomic stability.
Breast Neoplasms
FANCJ helicase uniquely senses oxidative base damage in either strand of duplex DNA and is stimulated by RPA to unwind the damaged DNA substrate in a strand-specific manner.
Breast Neoplasms
FANCJ localization by mismatch repair is vital to maintain genomic integrity after UV irradiation.
Breast Neoplasms
FANCJ uses its motor ATPase to destabilize protein-DNA complexes, unwind triplexes, and inhibit RAD51 strand exchange.
Breast Neoplasms
FANCJ: solving problems in DNA replication.
Breast Neoplasms
Fanconi Anemia Group J Helicase and MRE11 Nuclease Interact to Facilitate the DNA Damage Response.
Breast Neoplasms
Hereditary breast cancer and the BRCA1-associated FANCJ/BACH1/BRIP1.
Breast Neoplasms
Identification of RECQ1-regulated transcriptome uncovers a role of RECQ1 in regulation of cancer cell migration and invasion.
Breast Neoplasms
Insight into the Roles of Helicase Motif Ia by Characterizing Fanconi Anemia Group J Protein (FANCJ) Patient Mutations.
Breast Neoplasms
Loss of the BRCA1-Interacting Helicase BRIP1 Results in Abnormal Mammary Acinar Morphogenesis.
Breast Neoplasms
Minichromosome maintenance protein 2 is a reliable proliferative marker in breast carcinoma.
Breast Neoplasms
Minichromosome maintenance protein 2 is a strong independent prognostic marker in breast cancer.
Breast Neoplasms
Molecular and cellular functions of the FANCJ DNA helicase defective in cancer and in Fanconi anemia.
Breast Neoplasms
Mutational analysis of FANCJ helicase.
Breast Neoplasms
Mutational analysis of the breast cancer susceptibility gene BRIP1 /BACH1/FANCJ in high-risk non-BRCA1/BRCA2 breast cancer families.
Breast Neoplasms
Prognostic significance of minichromosome maintenance proteins in breast cancer.
Breast Neoplasms
RECQ1 expression is upregulated in response to DNA damage and in a p53-dependent manner.
Breast Neoplasms
RECQL: a DNA helicase in breast cancer.
Breast Neoplasms
RECQL: a new breast cancer susceptibility gene.
Breast Neoplasms
shRNA knockdown of DNA helicase ERCC6L expression inhibits human breast cancer growth.
Breast Neoplasms
Site-directed mutants of human RECQ1 reveal functional importance of the zinc binding domain.
Breast Neoplasms
Specialization among Iron-Sulfur Cluster Helicases to Resolve G-quadruplex DNA Structures That Threaten Genomic Stability.
Breast Neoplasms
Targeting the FANCJ-BRCA1 interaction promotes a switch from recombination to poleta-dependent bypass.
Breast Neoplasms
The BRCA1-interacting helicase BRIP1 is deficient in Fanconi anemia.
Breast Neoplasms
The effect of childbirth on carcinogenesis of DMBA-induced breast cancer in female SD rats.
Breast Neoplasms
The FANCJ/MutLalpha interaction is required for correction of the cross-link response in FA-J cells.
Breast Neoplasms
The Fanconi anemia/BRCA gene network in zebrafish: Embryonic expression and comparative genomics.
Breast Neoplasms
The prognostic potential of keratin 18 in breast cancer associated with tumor dedifferentiation, and the loss of estrogen and progesterone receptors.
Breast Neoplasms
The Q motif of Fanconi anemia group J protein (FANCJ) DNA helicase regulates its dimerization, DNA binding, and DNA repair function.
Breast Neoplasms
The synthetic antihyperlipidemic drug potassium piperate selectively kills breast cancer cells through inhibiting G1-S-phase transition and inducing apoptosis.
Breast Neoplasms
Transcriptomic and protein expression analysis reveals clinicopathological significance of Bloom's syndrome helicase (BLM) in breast cancer.
Breast Neoplasms
Utilization of fluorescence in situ hybridization with cytokeratin discriminators in TOP2A assessment of chemotherapy-treated patients with breast cancer.
Breast Neoplasms
Welcome the family of FANCJ-like helicases to the block of genome stability maintenance proteins.
Breast Neoplasms
[Deguelin inhibits proliferation and regulates the expression of MCM3-CDC45 in MCF-7 and H1299 cells in vitro].
Breast Neoplasms
[Preparation, characterization and application of monoclonal antibody against RecQ helicase].
Carcinogenesis
BRIP1 inhibits the tumorigenic properties of cervical cancer by regulating RhoA GTPase activity.
Carcinogenesis
Comparison of proliferation and genomic instability responses to WRN silencing in hematopoietic HL60 and TK6 cells.
Carcinogenesis
Decreased RECQL5 correlated with disease progression of osteosarcoma.
Carcinogenesis
DNA end resection controls the balance between homologous and illegitimate recombination in Escherichia coli.
Carcinogenesis
FANCJ couples replication past natural fork barriers with maintenance of chromatin structure.
Carcinogenesis
FANCJ helicase uniquely senses oxidative base damage in either strand of duplex DNA and is stimulated by RPA to unwind the damaged DNA substrate in a strand-specific manner.
Carcinogenesis
Generation of a mouse model for studying the role of upregulated RTEL1 activity in tumorigenesis.
Carcinogenesis
Involvement of WRN helicase in immortalization and tumorigenesis by the telomeric crisis pathway (Review).
Carcinogenesis
MCM7 amplification and overexpression promote cell proliferation, colony formation and migration in esophageal squamous cell carcinoma by activating the AKT1/mTOR signaling pathway.
Carcinogenesis
miR-522-3p promotes tumorigenesis in human colorectal cancer via targeting bloom syndrome protein.
Carcinogenesis
Nuclear DNA helicase II (RNA helicase A) interacts with Werner syndrome helicase and stimulates its exonuclease activity.
Carcinogenesis
Nuclear PGK1 Alleviates ADP-Dependent Inhibition of CDC7 to Promote DNA Replication.
Carcinogenesis
Overexpression of the BRIP1 ameliorates chemosensitivity to cisplatin by inhibiting Rac1 GTPase activity in cervical carcinoma HeLa cells.
Carcinogenesis
RecQ helicases and genome stability: lessons from model organisms and human disease.
Carcinogenesis
Recurrent amplification of RTEL1 and ABCA13 and its synergistic effect associated with clinicopathological data of gastric adenocarcinoma.
Carcinogenesis
Role for the Werner syndrome protein in the promotion of tumor cell growth.
Carcinogenesis
Role of Werner syndrome gene product helicase in carcinogenesis and in resistance to genotoxins by cancer cells.
Carcinogenesis
The function of RecQ helicase gene family (especially BLM) in DNA recombination and joining.
Carcinogenesis
The Werner syndrome helicase protein is required for cell proliferation, immortalization, and tumorigenesis in Scaffold Attachment Factor B1 deficient mice.
Carcinogenesis
Unique and important consequences of RECQ1 deficiency in mammalian cells.
Carcinogenesis
XPD-The Lynchpin of NER: Molecule, Gene, Polymorphisms, and Role in Colorectal Carcinogenesis.
Carcinoma
A new proliferation marker, minichromosome maintenance protein 2, is associated with tumor aggressiveness in esophageal squamous cell carcinoma.
Carcinoma
Cell proliferation marker MCM2, but not Ki67, is helpful for distinguishing between minimally invasive follicular carcinoma and follicular adenoma of the thyroid.
Carcinoma
Characterization of topoisomerase II ? and minichromosome maintenance protein 2 expression in anal carcinoma.
Carcinoma
Detecting high-grade cervical disease on ASC-H cytology: role of BD ProEx C and Digene Hybrid Capture II HPV DNA testing.
Carcinoma
DNA sequences proximal to human mitochondrial DNA deletion breakpoints prevalent in human disease form G-quadruplexes, a class of DNA structures inefficiently unwound by the mitochondrial replicative Twinkle helicase.
Carcinoma
Downregulation of Fanconi anemia genes in sporadic head and neck squamous cell carcinoma.
Carcinoma
Expression of Minichromosome Maintenance Proteins in Actinic Keratosis and Squamous Cell Carcinoma.
Carcinoma
Minichromosome maintenance protein 2 correlates with the malignant status and regulates proliferation and cell cycle in lung squamous cell carcinoma.
Carcinoma
Minichromosome maintenance protein 2 expression in normal kidney and renal cell carcinomas: relationship to tumor dormancy and potential clinical utility.
Carcinoma
Minichromosome maintenance protein 7 and geminin expression: Prognostic value in laryngeal squamous cell carcinoma in patients treated with radiotherapy and cetuximab.
Carcinoma
Minichromosome maintenance protein 7 as a potential prognostic factor for progression-free survival in high-grade serous carcinomas of the ovary.
Carcinoma
Nucleolar localization of the Werner syndrome protein in human cells.
Carcinoma
Potential role of minichromosome maintenance protein 2 as a screening biomarker in esophageal cancer high-risk population in China.
Carcinoma
Prognostic value of MCM2 immunoreactivity in stage T1 transitional cell carcinoma of the bladder.
Carcinoma in Situ
Potential role of minichromosome maintenance protein 2 as a screening biomarker in esophageal cancer high-risk population in China.
Carcinoma, Hepatocellular
Generation of a mouse model for studying the role of upregulated RTEL1 activity in tumorigenesis.
Carcinoma, Hepatocellular
Genetic study of congenital bile-duct dilatation identifies de novo and inherited variants in functionally related genes.
Carcinoma, Hepatocellular
Overexpression and role of the ATPase and putative DNA helicase RuvB-like 2 in human hepatocellular carcinoma.
Carcinoma, Hepatocellular
Upregulation of RECQL4 expression predicts poor prognosis in hepatocellular carcinoma.
Carcinoma, Non-Small-Cell Lung
Effects of RECQ1 helicase silencing on non-small cell lung cancer cells.
Carcinoma, Non-Small-Cell Lung
Minichromosome Maintenance Protein 7 is a potential therapeutic target in human cancer and a novel prognostic marker of non-small cell lung cancer.
Carcinoma, Renal Cell
DNA sequences proximal to human mitochondrial DNA deletion breakpoints prevalent in human disease form G-quadruplexes, a class of DNA structures inefficiently unwound by the mitochondrial replicative Twinkle helicase.
Carcinoma, Renal Cell
Minichromosome maintenance protein 2 expression in normal kidney and renal cell carcinomas: relationship to tumor dormancy and potential clinical utility.
Carcinoma, Squamous Cell
Detecting high-grade cervical disease on ASC-H cytology: role of BD ProEx C and Digene Hybrid Capture II HPV DNA testing.
Carcinoma, Squamous Cell
Expression of Minichromosome Maintenance Proteins in Actinic Keratosis and Squamous Cell Carcinoma.
Carcinoma, Squamous Cell
Genome-wide association study of familial lung cancer.
Carcinoma, Squamous Cell
Minichromosome maintenance protein 2 correlates with the malignant status and regulates proliferation and cell cycle in lung squamous cell carcinoma.
Carcinoma, Squamous Cell
Minichromosome maintenance protein 7 and geminin expression: Prognostic value in laryngeal squamous cell carcinoma in patients treated with radiotherapy and cetuximab.
Cardiomyopathies
Mutation in TWINKLE in a Large Iranian Family with Progressive External Ophthalmoplegia, Myopathy, Dysphagia and Dysphonia, and Behavior Change.
Cardiomyopathies
Overexpression of Twinkle-helicase protects cardiomyocytes from genotoxic stress caused by reactive oxygen species.
Cardiomyopathies
Twinkle overexpression prevents cardiac rupture after myocardial infarction by alleviating impaired mitochondrial biogenesis.
Cardiomyopathy, Hypertrophic
Novel biallelic TRNT1 mutations resulting in sideroblastic anemia, combined B and T cell defects, hypogammaglobulinemia, recurrent infections, hypertrophic cardiomyopathy and developmental delay.
Cataract
Mutation in TWINKLE in a Large Iranian Family with Progressive External Ophthalmoplegia, Myopathy, Dysphagia and Dysphonia, and Behavior Change.
Cataract
What can we learn from Werner syndrome? A biased view from a rheumatologist.
cca trna nucleotidyltransferase deficiency
TRNT1 deficiency: clinical, biochemical and molecular genetic features.
Cerebellar Ataxia
Infantile onset spinocerebellar ataxia caused by compound heterozygosity for Twinkle mutations and modeling of Twinkle mutations causing recessive disease.
Cervical Intraepithelial Neoplasia
A cocktail of MCM2 and TOP2A, p16INK4a and Ki-67 as biomarkers for the improved diagnosis of cervical intraepithelial lesion.
Cholangiocarcinoma
Transcriptional induction of minichromosome maintenance protein 7 (Mcm7) in human cholangiocarcinoma cells treated with Clonorchis sinensis excretory-secretory products.
Cholecystitis
Clinicopathologic significance of minichromosome maintenance protein 2 and Tat-interacting protein 30 expression in benign and malignant lesions of the gallbladder.
Cholera
CTX?: Exploring new alternatives in host factor-mediated filamentous phage replications.
Chondroma
Minichromosome maintenance protein (MCM6) in low-grade chondrosarcoma: distinction from enchondroma and identification of progressive tumors.
Chondrosarcoma
Minichromosome maintenance protein (MCM6) in low-grade chondrosarcoma: distinction from enchondroma and identification of progressive tumors.
Cockayne Syndrome
Phenotypic heterogeneity in the XPB DNA helicase gene (ERCC3): xeroderma pigmentosum without and with Cockayne syndrome.
Cockayne Syndrome
The DNA helicases acting in nucleotide excision repair, XPD, CSB and XPB, are not required for PCNA-dependent repair of abasic sites.
Coinfection
Adeno-associated virus small rep proteins are modified with at least two types of polyubiquitination.
Coinfection
Inhibition of Bombyx mori nuclear polyhedrosis virus (NPV) replication by the putative DNA helicase gene of Autographa californica NPV.
Colonic Neoplasms
Interaction between RAD51 and MCM Complex Is Essential for RAD51 Foci Forming in Colon Cancer HCT116 Cells.
Colorectal Neoplasms
Altered RECQ Helicase Expression in Sporadic Primary Colorectal Cancers.
Colorectal Neoplasms
Analysis of minichromosome maintenance proteins as a novel method for detection of colorectal cancer in stool.
Colorectal Neoplasms
FANCJ Expression Predicts the Response to 5-Fluorouracil-Based Chemotherapy in MLH1-Proficient Colorectal Cancer.
Colorectal Neoplasms
Interactions between SAP155 and FUSE-binding protein-interacting repressor bridges c-Myc and P27Kip1 expression.
Colorectal Neoplasms
MINICHROMOSOME MAINTENANCE PROTEIN 2 (MCM2) IS A STRONGER DISCRIMINATOR OF INCREASED PROLIFERATION IN MUCOSA ADJACENT TO COLORECTAL CANCER THAN Ki-67.
Colorectal Neoplasms
Minichromosome maintenance protein 7 in colorectal cancer: implication of prognostic significance.
Colorectal Neoplasms
Minichromosome maintenance protein 7 is a risk factor for recurrence in patients with Dukes C colorectal cancer.
Colorectal Neoplasms
miR-522-3p promotes tumorigenesis in human colorectal cancer via targeting bloom syndrome protein.
Colorectal Neoplasms
WRN Promoter CpG Island Hypermethylation Does Not Predict More Favorable Outcomes for Patients with Metastatic Colorectal Cancer Treated with Irinotecan-Based Therapy.
Coronary Disease
Genetic analysis of the relation of telomere length-related gene (RTEL1) and coronary heart disease risk.
Craniopharyngioma
[Expression of minichromosome maintenance protein 6 in craniopharyngioma and its correlation with prognosis]
Cysts
Determination of potential cellular proliferation in the odontogenic epithelia of the dental follicle of the asymptomatic impacted third molars.
Deglutition Disorders
A novel variation in the Twinkle linker region causing late-onset dementia.
Deglutition Disorders
Mutation in TWINKLE in a Large Iranian Family with Progressive External Ophthalmoplegia, Myopathy, Dysphagia and Dysphonia, and Behavior Change.
Deglutition Disorders
TWINKLE gene mutation: report of a French family with an autosomal dominant progressive external ophthalmoplegia and literature review.
Dementia
A novel variation in the Twinkle linker region causing late-onset dementia.
Dementia
Mutation in TWINKLE in a Large Iranian Family with Progressive External Ophthalmoplegia, Myopathy, Dysphagia and Dysphonia, and Behavior Change.
Dengue
Dengue NS3, an RNAi suppressor, modulates the human miRNA pathways through its interacting partner.
Dengue
Novel Insights into the Molecular Interaction of a Panduratin A Derivative with the Non Structural Protein (NS3) of Dengue Serotypes: A Molecular Dynamics Study.
Dengue
Towards the design of flavivirus helicase/NTPase inhibitors: crystallographic and mutagenesis studies of the dengue virus NS3 helicase catalytic domain.
Dental Caries
Minichromosome maintenance protein 7 regulates phagocytosis in kuruma shrimp Marsupenaeus japonicas against white spot syndrome virus.
Dental Caries
Molecular characterization of minichromosome maintenance protein (MCM7) in Scylla paramamosain and its role in white spot syndrome virus and Vibrio alginolyticus infection.
Diabetic Nephropathies
ACE, PAI-1, decorin and Werner helicase genes are not associated with the development of renal disease in European patients with type 1 diabetes.
Diffuse Cerebral Sclerosis of Schilder
Molecular analysis of ANT1, TWINKLE and POLG in patients with multiple deletions or depletion of mitochondrial DNA by a dHPLC-based assay.
Diffuse Cerebral Sclerosis of Schilder
Recessive Twinkle mutations in early onset encephalopathy with mtDNA depletion.
dna helicase deficiency
Aging stem cells. A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging.
dna helicase deficiency
An MLH1 Mutation Links BACH1/FANCJ to Colon Cancer, Signaling, and Insight toward Directed Therapy.
dna helicase deficiency
Clinical and Molecular Heterogeneity of RTEL1 Deficiency.
dna helicase deficiency
Corrigendum: Clinical and Molecular Heterogeneity of RTEL1 Deficiency.
dna helicase deficiency
Deficiency of the Arabidopsis Helicase RTEL1 Triggers a SOG1-Dependent Replication Checkpoint in Response to DNA Cross-Links.
dna helicase deficiency
DNA helicase deficiencies associated with cancer predisposition and premature ageing disorders.
dna helicase deficiency
Effect of minichromosome maintenance protein 2 deficiency on the locations of DNA replication origins.
dna helicase deficiency
Elevated telomere-telomere recombination in WRN-deficient, telomere dysfunctional cells promotes escape from senescence and engagement of the ALT pathway.
dna helicase deficiency
FANCJ localization by mismatch repair is vital to maintain genomic integrity after UV irradiation.
dna helicase deficiency
Heterozygous RTEL1 mutations are associated with familial pulmonary fibrosis.
dna helicase deficiency
Human premature aging, DNA repair and RecQ helicases.
dna helicase deficiency
Human RECQ Helicase Pathogenic Variants, Population Variation and "Missing" Diseases.
dna helicase deficiency
Human RECQ5 helicase promotes repair of DNA double-strand breaks by synthesis-dependent strand annealing.
dna helicase deficiency
Human RTEL1 deficiency causes Hoyeraal-Hreidarsson syndrome with short telomeres and genome instability.
dna helicase deficiency
Pyrimidine Pool Disequilibrium Induced by a Cytidine Deaminase Deficiency Inhibits PARP-1 Activity, Leading to the Under Replication of DNA.
dna helicase deficiency
RECQ1 interacts with FEN-1 and promotes binding of FEN-1 to telomeric chromatin.
dna helicase deficiency
Unique and important consequences of RECQ1 deficiency in mammalian cells.
dna helicase deficiency
WRN regulates pathway choice between classical and alternative non-homologous end joining.
dna helicase deficiency
[Role of RecQ5 in syncytial blastoderm of the Drosophila embryo].
Dysarthria
Molecular analysis of ANT1, TWINKLE and POLG in patients with multiple deletions or depletion of mitochondrial DNA by a dHPLC-based assay.
Dysarthria
SANDO: Two novel mutations in POLG1 gene.
Dysarthria
TWINKLE gene mutation: report of a French family with an autosomal dominant progressive external ophthalmoplegia and literature review.
Dyskeratosis Congenita
Complex phenotype of dyskeratosis congenita and mood dysregulation with novel homozygous RTEL1 and TPH1 variants.
Dyskeratosis Congenita
Constitutional Mutations in RTEL1 Cause Severe Dyskeratosis Congenita.
Dyskeratosis Congenita
Exome sequencing links mutations in PARN and RTEL1 with familial pulmonary fibrosis and telomere shortening.
Dyskeratosis Congenita
Generation of an Rtel1-CreERT2 knock-in mouse model for lineage tracing RTEL1+ stem cells during development.
Dyskeratosis Congenita
Germline mutations of regulator of telomere elongation helicase 1, RTEL1, in Dyskeratosis congenita.
Dyskeratosis Congenita
Mutant mice lacking the p53 C-terminal domain model telomere syndromes.
Dyskeratosis Congenita
RTEL1: functions of a disease-associated helicase.
Dyskeratosis Congenita
Specialization among Iron-Sulfur Cluster Helicases to Resolve G-quadruplex DNA Structures That Threaten Genomic Stability.
Dyskeratosis Congenita
Telomere shortening by mutations in the RTEL1 helicase cause severe form of dyskeratosis congenita, Hoyerall-Hreidarsson syndrome.
Dyskeratosis Congenita
The C-terminal extension of human RTEL1, mutated in Hoyeraal-Hreidarsson syndrome, contains Harmonin-N-like domains.
Dyskeratosis Congenita
[Recurrent pulmonary infection and oral mucosal ulcer].
Dyskeratosis Congenita
[RTEL1 (regulator of telomere elongation helicase 1), a DNA helicase essential for genome stability].
Dysphonia
A novel variation in the Twinkle linker region causing late-onset dementia.
Dysphonia
Mutation in TWINKLE in a Large Iranian Family with Progressive External Ophthalmoplegia, Myopathy, Dysphagia and Dysphonia, and Behavior Change.
Dysplastic Nevus Syndrome
Minichromosome maintenance protein expression in benign nevi, dysplastic nevi, melanoma, and cutaneous melanoma metastases.
Dysplastic Nevus Syndrome
On the interplay of telomeres, nevi and the risk of melanoma.
Epidermal Cyst
Twinkle artefact in the ultrasound diagnosis of superficial epidermoid cysts.
Epilepsy
Mesencephalic complex I deficiency does not correlate with parkinsonism in mitochondrial DNA maintenance disorders.
Epilepsy
Migraine and epilepsy: A focus on overlapping clinical, pathophysiological, molecular, and therapeutic aspects.
Epilepsy
Molecular analysis of ANT1, TWINKLE and POLG in patients with multiple deletions or depletion of mitochondrial DNA by a dHPLC-based assay.
Epilepsy
NG2+/Olig2+ Cells Are the Major Cycle-Related Cell Population of the Adult Human Normal Brain.
Epilepsy, Temporal Lobe
NG2+/Olig2+ Cells Are the Major Cycle-Related Cell Population of the Adult Human Normal Brain.
Esophageal Neoplasms
Potential role of minichromosome maintenance protein 2 as a screening biomarker in esophageal cancer high-risk population in China.
Esophageal Squamous Cell Carcinoma
A new proliferation marker, minichromosome maintenance protein 2, is associated with tumor aggressiveness in esophageal squamous cell carcinoma.
Esophageal Squamous Cell Carcinoma
Potential role of minichromosome maintenance protein 2 as a screening biomarker in esophageal cancer high-risk population in China.
Fanconi Anemia
Aberrant recombination and repair during immunoglobulin class switching in BRCA1-deficient human B cells.
Fanconi Anemia
Assessing the link between BACH1/FANCJ and MLH1 in DNA crosslink repair.
Fanconi Anemia
BACH1 is critical for homologous recombination and appears to be the Fanconi anemia gene product FANCJ.
Fanconi Anemia
Biochemical characterization of Warsaw breakage syndrome helicase.
Fanconi Anemia
BLM's balancing act and the involvement of FANCJ in DNA repair.
Fanconi Anemia
BRCA1-mediated repression of mutagenic end-joining of DNA double-strand breaks requires complex formation with BACH1.
Fanconi Anemia
Chl1 DNA Helicase Regulates Scc2 Deposition Specifically during DNA-Replication in Saccharomyces cerevisiae.
Fanconi Anemia
Conserved overlapping gene arrangement, restricted expression, and biochemical activities of DNA polymerase ? (POLN).
Fanconi Anemia
CtIP- and ATR-dependent FANCJ phosphorylation in response to DNA strand breaks mediated by DNA replication.
Fanconi Anemia
Decreased FANCJ caused by 5FU contributes to the increased sensitivity to oxaliplatin in gastric cancer cells.
Fanconi Anemia
Disease-causing missense mutations in human DNA helicase disorders.
Fanconi Anemia
DNA helicases associated with genetic instability, cancer, and aging.
Fanconi Anemia
Emergence of a DNA-damage response network consisting of Fanconi anaemia and BRCA proteins.
Fanconi Anemia
FANCD2 limits BLM-dependent telomere instability in the alternative lengthening of telomeres pathway.
Fanconi Anemia
FANCD2, FANCJ and BRCA2 cooperate to promote replication fork recovery independently of the Fanconi Anemia core complex.
Fanconi Anemia
FancJ (Brip1) loss-of-function allele results in spermatogonial cell depletion during embryogenesis and altered processing of crossover sites during meiotic prophase I in mice.
Fanconi Anemia
FANCJ Expression Predicts the Response to 5-Fluorouracil-Based Chemotherapy in MLH1-Proficient Colorectal Cancer.
Fanconi Anemia
FANCJ helicase controls the balance between short- and long-tract gene conversions between sister chromatids.
Fanconi Anemia
FANCJ helicase defective in Fanconia anemia and breast cancer unwinds G-quadruplex DNA to defend genomic stability.
Fanconi Anemia
FANCJ helicase operates in the Fanconi Anemia DNA repair pathway and the response to replicational stress.
Fanconi Anemia
FANCJ helicase uniquely senses oxidative base damage in either strand of duplex DNA and is stimulated by RPA to unwind the damaged DNA substrate in a strand-specific manner.
Fanconi Anemia
FANCJ localization by mismatch repair is vital to maintain genomic integrity after UV irradiation.
Fanconi Anemia
FANCJ promotes DNA synthesis through G-quadruplex structures.
Fanconi Anemia
FancJ regulates interstrand crosslinker induced centrosome amplification through the activation of polo-like kinase 1.
Fanconi Anemia
FANCJ suppresses microsatellite instability and lymphomagenesis independent of the Fanconi anemia pathway.
Fanconi Anemia
FANCJ uses its motor ATPase to destabilize protein-DNA complexes, unwind triplexes, and inhibit RAD51 strand exchange.
Fanconi Anemia
FANCJ/BRIP1 recruitment and regulation of FANCD2 in DNA damage responses.
Fanconi Anemia
FANCJ: solving problems in DNA replication.
Fanconi Anemia
Fanconi Anemia Complementation Group FANCD2 Protein Serine 331 Phosphorylation Is Important for Fanconi Anemia Pathway Function and BRCA2 Interaction.
Fanconi Anemia
Fanconi Anemia Group J Helicase and MRE11 Nuclease Interact to Facilitate the DNA Damage Response.
Fanconi Anemia
Helicase-inactivating mutations as a basis for dominant negative phenotypes.
Fanconi Anemia
Hereditary breast cancer and the BRCA1-associated FANCJ/BACH1/BRIP1.
Fanconi Anemia
HP1 regulates the localization of FANCJ at sites of DNA double-strand breaks.
Fanconi Anemia
Inhibition of helicase activity by a small molecule impairs Werner syndrome helicase (WRN) function in the cellular response to DNA damage or replication stress.
Fanconi Anemia
Insight into the Roles of Helicase Motif Ia by Characterizing Fanconi Anemia Group J Protein (FANCJ) Patient Mutations.
Fanconi Anemia
Molecular and cellular functions of the FANCJ DNA helicase defective in cancer and in Fanconi anemia.
Fanconi Anemia
Mutagenic capacity of endogenous G4 DNA underlies genome instability in FANCJ-defective C. elegans.
Fanconi Anemia
Mutational analysis of FANCJ helicase.
Fanconi Anemia
Novel function of the Fanconi anemia group J or RECQ1 helicase to disrupt protein-DNA complexes in a replication protein A-stimulated manner.
Fanconi Anemia
Opposing Roles of FANCJ and HLTF Protect Forks and Restrain Replication during Stress.
Fanconi Anemia
Specialization among Iron-Sulfur Cluster Helicases to Resolve G-quadruplex DNA Structures That Threaten Genomic Stability.
Fanconi Anemia
Subependymal giant cell astrocytoma-like astrocytoma: a neoplasm with a distinct phenotype and frequent neurofibromatosis type-1-association.
Fanconi Anemia
Targeting an Achilles' heel of cancer with a WRN helicase inhibitor.
Fanconi Anemia
The DNA helicase BRIP1 is defective in Fanconi anemia complementation group J.
Fanconi Anemia
The DNA repair helicases XPD and FancJ have essential iron-sulfur domains.
Fanconi Anemia
The FANCJ/MutLalpha interaction is required for correction of the cross-link response in FA-J cells.
Fanconi Anemia
The Fanconi anemia proteins FANCD2 and FANCJ interact and regulate each other's chromatin localization.
Fanconi Anemia
The Q motif of Fanconi anemia group J protein (FANCJ) DNA helicase regulates its dimerization, DNA binding, and DNA repair function.
Fanconi Anemia
Warsaw breakage syndrome, a cohesinopathy associated with mutations in the XPD helicase family member DDX11/ChlR1.
Fanconi Anemia
Welcome the family of FANCJ-like helicases to the block of genome stability maintenance proteins.
Fanconi Anemia
Werner syndrome helicase has a critical role in DNA damage responses in the absence of a functional fanconi anemia pathway.
Fanconi Anemia
[DNA helicases and human diseases]
Fragile X Syndrome
Human werner syndrome DNA helicase unwinds tetrahelical structures of the fragile X syndrome repeat sequence d(CGG)n.
Gastrointestinal Stromal Tumors
Does Immunohistochemistry for Discovered on GIST1 and Minichromosome Maintenance Protein7 Provide Additional Clinicopathological Value in Gastrointestinal Stromal Tumors?
GATA2 Deficiency
A homozygous mutation of RTEL1 in a child presenting with an apparently isolated natural killer cell deficiency.
Genetic Diseases, Inborn
ATM-dependent phosphorylation and accumulation of endogenous BLM protein in response to ionizing radiation.
Genetic Diseases, Inborn
Biochemical Characterization of the Human Mitochondrial Replicative Twinkle Helicase: SUBSTRATE SPECIFICITY, DNA BRANCH MIGRATION, AND ABILITY TO OVERCOME BLOCKADES TO DNA UNWINDING.
Genetic Diseases, Inborn
Characterization of the slow-growth phenotype of S. cerevisiae Whip/Mgs1 Sgs1 double deletion mutants.
Genetic Diseases, Inborn
Cigarette smoke induces cellular senescence via Werner's syndrome protein down-regulation.
Genetic Diseases, Inborn
Defining the roles of the N-terminal region and the helicase activity of RECQ4A in DNA repair and homologous recombination in Arabidopsis.
Genetic Diseases, Inborn
Differential regulation of human RecQ family helicases in cell transformation and cell cycle.
Genetic Diseases, Inborn
Down-regulation of the defective transcripts of the Werner's syndrome gene in the cells of patients.
Genetic Diseases, Inborn
Genetic Manipulation of Homologous Recombination In Vivo Attenuates Intestinal Tumorigenesis.
Genetic Diseases, Inborn
Human RECQ1 Is a DNA Damage Responsive Protein Required for Genotoxic Stress Resistance and Suppression of Sister Chromatid Exchanges.
Genetic Diseases, Inborn
IDIOPATHIC PULMONARY FIBROSIS IS A COMPLEX GENETIC DISORDER.
Genetic Diseases, Inborn
Idiopathic Pulmonary Fibrosis: A Genetic Disease That Involves Mucociliary Dysfunction of the Peripheral Airways.
Genetic Diseases, Inborn
Molecular biology of Werner syndrome.
Genetic Diseases, Inborn
Protein kinase A subunit expression is altered in Bloom syndrome fibroblasts and the BLM protein is increased in adrenocortical hyperplasias: inverse findings for BLM and PRKAR1A.
Genetic Diseases, Inborn
RECQ DNA helicases and osteosarcoma.
Genetic Diseases, Inborn
Strand exchange of telomeric DNA catalyzed by the Werner syndrome protein (WRN) is specifically stimulated by TRF2.
Genetic Diseases, Inborn
Unique and important consequences of RECQ1 deficiency in mammalian cells.
Genetic Diseases, Inborn
Werner syndrome protein participates in a complex with RAD51, RAD54, RAD54B and ATR in response to ICL-induced replication arrest.
Genetic Diseases, Inborn
Werner's syndrome as a hereditary risk factor for exocrine pancreatic cancer: Potential role of WRN in pancreatic tumorigenesis and patient-tailored therapy.
Gestational Trophoblastic Disease
Minichromosome maintenance protein 7 expression in gestational trophoblastic disease: correlation with Ki67, PCNA and clinicopathological parameters.
Glioblastoma
Analysis of difference of association between polymorphisms in the XRCC5, RPA3 and RTEL1 genes and glioma, astrocytoma and glioblastoma.
Glioblastoma
Association between RTEL1, PHLDB1, and TREH Polymorphisms and Glioblastoma Risk: A Case-Control Study.
Glioblastoma
Association of sequence variants on chromosomes 20, 11, and 5 (20q13.33, 11q23.3, and 5p15.33) with glioma susceptibility in a chinese population.
Glioblastoma
Depletion of minichromosome maintenance protein 7 inhibits glioblastoma multiforme tumor growth in vivo.
Glioblastoma
Genetic risk variants in the CDKN2A/B, RTEL1 and EGFR genes are associated with somatic biomarkers in glioma.
Glioblastoma
Minichromosome maintenance protein 7: a reliable tool for glioblastoma proliferation index.
Glioblastoma
Polymorphisms of LIG4, BTBD2, HMGA2, and RTEL1 genes involved in the double-strand break repair pathway predict glioblastoma survival.
Glioblastoma
RECQ1 Helicase Silencing Decreases the Tumour Growth Rate of U87 Glioblastoma Cell Xenografts in Zebrafish Embryos.
Glioblastoma
RTEL1: functions of a disease-associated helicase.
Glioblastoma
The human RECQ1 helicase is highly expressed in glioblastoma and plays an important role in tumor cell proliferation.
Glioma
Analysis of 60 reported glioma risk SNPs replicates published GWAS findings but fails to replicate associations from published candidate-gene studies.
Glioma
Analysis of difference of association between polymorphisms in the XRCC5, RPA3 and RTEL1 genes and glioma, astrocytoma and glioblastoma.
Glioma
Association analysis of RTEL1 variants with risk of adult gliomas in a Korean population.
Glioma
Association between glioma susceptibility loci and tumour pathology defines specific molecular etiologies.
Glioma
Association of sequence variants on chromosomes 20, 11, and 5 (20q13.33, 11q23.3, and 5p15.33) with glioma susceptibility in a chinese population.
Glioma
Associations between the rs6010620 polymorphism in RTEL1 and risk of glioma: a meta-analysis of 20,711 participants.
Glioma
Cancer susceptibility variants and the risk of adult glioma in a US case-control study.
Glioma
Cho/Cr ratio at MR spectroscopy as a biomarker for cellular proliferation activity and prognosis in glioma: correlation with the expression of minichromosome maintenance protein 2.
Glioma
Distinct germ line polymorphisms underlie glioma morphologic heterogeneity.
Glioma
Fine mapping analysis of a region of 20q13.33 identified five independent susceptibility loci for glioma in a Chinese Han population.
Glioma
Genetic risk variants in the CDKN2A/B, RTEL1 and EGFR genes are associated with somatic biomarkers in glioma.
Glioma
Genome-wide association study identifies five susceptibility loci for glioma.
Glioma
New insights into susceptibility to glioma.
Glioma
Regulator of telomere elongation helicase 1 (RTEL1) rs6010620 polymorphism contribute to increased risk of glioma.
Glioma
RTEL1 tagging SNPs and haplotypes were associated with glioma development.
Glioma
RTEL1: functions of a disease-associated helicase.
Glioma
Telomere length and risk of glioma.
Glioma
The role of the RTEL1 rs2297440 polymorphism in the risk of glioma development: a meta-analysis.
Glioma
The RTEL1 rs6010620 polymorphism and glioma risk: a meta-analysis based on 12 case-control studies.
Glioma
Variants in the CDKN2B and RTEL1 regions are associated with high-grade glioma susceptibility.
Head and Neck Neoplasms
Identification of biomarkers that distinguish human papillomavirus (HPV)-positive versus HPV-negative head and neck cancers in a mouse model.
Hearing Loss
A novel variation in the Twinkle linker region causing late-onset dementia.
Hearing Loss
Mutation in TWINKLE in a Large Iranian Family with Progressive External Ophthalmoplegia, Myopathy, Dysphagia and Dysphonia, and Behavior Change.
Heart Diseases
The overexpression of Twinkle helicase ameliorates the progression of cardiac fibrosis and heart failure in pressure overload model in mice.
Heart Failure
The overexpression of Twinkle helicase ameliorates the progression of cardiac fibrosis and heart failure in pressure overload model in mice.
Heart Rupture
Twinkle overexpression prevents cardiac rupture after myocardial infarction by alleviating impaired mitochondrial biogenesis.
Hematologic Neoplasms
RECQ helicases are deregulated in hematological malignancies in association with a prognostic value.
Hepatitis B
Hepatitis B virus transactivator protein, HBx, associates with the components of TFIIH and stimulates the DNA helicase activity of TFIIH.
Hepatitis C
Comparisons between the structures of HCV and Rep helicases reveal structural similarities between SF1 and SF2 super-families of helicases.
Hepatitis C
Crystal structure of the ATPase domain of translation initiation factor 4A from Saccharomyces cerevisiae--the prototype of the DEAD box protein family.
Hepatitis C
DNA helicase activity of the hepatitis C virus nonstructural protein 3.
Hepatitis C
Hepatitis C virus NS3 NTPase/helicase: different stereoselectivity in nucleoside triphosphate utilisation suggests that NTPase and helicase activities are coupled by a nucleotide-dependent rate limiting step.
Hepatitis C
Structurally conserved amino Acid w501 is required for RNA helicase activity but is not essential for DNA helicase activity of hepatitis C virus NS3 protein.
Hepatitis C
The hepatitis C viral NS3 protein is a processive DNA helicase with cofactor enhanced RNA unwinding.
Hepatitis C
The macroscopic rate of nucleic acid translocation by hepatitis C virus helicase NS3h is dependent on both sugar and base moieties.
Herpes Simplex
A DNA helicase induced by herpes simplex virus type 1.
Herpes Simplex
A novel conformation of the herpes simplex virus origin of DNA replication recognized by the origin binding protein.
Herpes Simplex
Association of DNA helicase and primase activities with a subassembly of the herpes simplex virus 1 helicase-primase composed of the UL5 and UL52 gene products.
Herpes Simplex
Complex of the herpes simplex virus type 1 origin binding protein UL9 with DNA as a platform for the design of a new type of antiviral drugs.
Herpes Simplex
Functional properties of the herpes simplex virus type I origin-binding protein are controlled by precise interactions with the activated form of the origin of DNA replication.
Herpes Simplex
Herpes simplex virus 1 helicase-primase: a complex of three herpes-encoded gene products.
Herpes Simplex
Herpes simplex virus DNA replication: a spacer sequence directs the ATP-dependent formation of a nucleoprotein complex at oriS.
Herpes Simplex
Herpes simplex virus helicase-primase: the UL8 protein is not required for DNA-dependent ATPase and DNA helicase activities.
Herpes Simplex
Identification of residues within the herpes simplex virus type 1 origin-binding protein that contribute to sequence-specific DNA binding.
Herpes Simplex
Inhibition of herpes simplex virus replication by a 2-amino thiazole via interactions with the helicase component of the UL5-UL8-UL52 complex.
Herpes Simplex
Inhibition of herpes simplex virus type 1 DNA replication by mutant forms of the origin-binding protein.
Herpes Simplex
Interactions of a subassembly of the herpes simplex virus type 1 helicase-primase with DNA.
Herpes Simplex
Modulation of the herpes simplex virus type-1 UL9 DNA helicase by its cognate single-strand DNA-binding protein, ICP8.
Herpes Simplex
Sequence of the HindIII T fragment of human cytomegalovirus, which encodes a DNA helicase.
Herpes Simplex
The DNA ligands influence the interactions between the herpes simplex virus 1 origin binding protein and the single strand DNA-binding protein, ICP-8.
Herpes Simplex
The herpes simplex virus 1 origin binding protein: a DNA helicase.
Herpes Simplex
The herpes simplex virus type 1 origin-binding protein carries out origin specific DNA unwinding and forms stem-loop structures.
Herpes Simplex
The herpes simplex virus type 1 origin-binding protein interacts specifically with the viral UL8 protein.
Herpes Simplex
The herpes simplex virus type-1 origin binding protein. DNA helicase activity.
Herpes Simplex
The herpes simplex virus type-1 single-strand DNA-binding protein, ICP8, increases the processivity of the UL9 protein DNA helicase.
Herpes Simplex
The origin-binding domain of the herpes simplex virus type 1 UL9 protein is not required for DNA helicase activity.
Herpes Simplex
[Complex of the herpes simplex virus initiator protein UL9 with DNA as a platform for the design of a new type of antiviral drugs]
Hodgkin Disease
Correlation of Minichromosome Maintenance Protein 6 Expression Rate and Clinical Outcome in Patients With Hodgkin's Lymphoma.
Hodgkin Disease
High Expression of Minichromosome Maintenance Protein 6 in Classic Hodgkin's Lymphoma Points to a Cell Cycle Arrest in G1 Phase.
Hypersensitivity
Arabidopsis RecQsim, a plant-specific member of the RecQ helicase family, can suppress the MMS hypersensitivity of the yeast sgs1 mutant.
Hypersensitivity
Cellular Werner phenotypes in mice expressing a putative dominant-negative human WRN gene.
Hypersensitivity
Defining the roles of the N-terminal region and the helicase activity of RECQ4A in DNA repair and homologous recombination in Arabidopsis.
Hypersensitivity
Histone H2A phosphorylation controls Crb2 recruitment at DNA breaks, maintains checkpoint arrest, and influences DNA repair in fission yeast.
Hypersensitivity
Homologous recombination resolution defect in werner syndrome.
Hypersensitivity
Pathways of Resistance to Thymineless Death in Escherichia coli and the Function of UvrD.
Hypersensitivity
The helicase domain and C-terminus of human RecQL4 facilitate replication elongation on DNA templates damaged by ionizing radiation.
Hypertriglyceridemia
Liver Aging and Pseudocapillarization in a Werner Syndrome Mouse Model.
Hypokalemia
Age-related changes in renal function, membrane protein metabolism, and Na,K-ATPase activity and abundance in hypokalemic F344 x BNF(1) rats.
Ichthyosis
Specialization among Iron-Sulfur Cluster Helicases to Resolve G-quadruplex DNA Structures That Threaten Genomic Stability.
Ichthyosis
Trypanosoma brucei harbours a divergent XPB helicase paralogue that is specialized in nucleotide excision repair and conserved among kinetoplastid organisms.
Idiopathic Pulmonary Fibrosis
IDIOPATHIC PULMONARY FIBROSIS IS A COMPLEX GENETIC DISORDER.
Idiopathic Pulmonary Fibrosis
Idiopathic Pulmonary Fibrosis: A Genetic Disease That Involves Mucociliary Dysfunction of the Peripheral Airways.
Illusions
Illusory stimuli can be used to identify retinal blind spots.
Infection
Abortive infection of the baculovirus Autographa californica nuclear polyhedrosis virus in Sf-9 cells after mutation of the putative DNA helicase gene.
Infection
Adeno-associated virus rep protein synthesis during productive infection.
Infection
Characterization of the transcription profile of adeno-associated virus type 5 reveals a number of unique features compared to previously characterized adeno-associated viruses.
Infection
Comparative analysis of chrysanthemum transcriptome in response to three RNA viruses: Cucumber mosaic virus, Tomato spotted wilt virus and Potato virus X.
Infection
DEAD-Box Helicase DDX25 Is a Negative Regulator of Type I Interferon Pathway and Facilitates RNA Virus Infection.
Infection
Differential gene expression profile from haematopoietic tissue stem cells of red claw crayfish, Cherax quadricarinatus, in response to WSSV infection.
Infection
DNA helicase requirements for DNA replication during bacteriophage T4 infection.
Infection
Establishment and analysis of the prediction model for cervical squamous cell carcinoma.
Infection
Evaluation of peracid formation as the basis for resistance to infection in plants transformed with haloperoxidase.
Infection
Herpes simplex virus 1 helicase-primase: a complex of three herpes-encoded gene products.
Infection
High-Definition Analysis of Host Protein Stability during Human Cytomegalovirus Infection Reveals Antiviral Factors and Viral Evasion Mechanisms.
Infection
Human cytomegalovirus protein pUL117 targets the mini-chromosome maintenance complex and suppresses cellular DNA synthesis.
Infection
Interaction of the bacteriophage T4 gene 59 helicase loading protein and gene 41 helicase with each other and with fork, flap, and cruciform DNA.
Infection
Molecular characterization of minichromosome maintenance protein (MCM7) in Scylla paramamosain and its role in white spot syndrome virus and Vibrio alginolyticus infection.
Infection
Molecular targets for human papillomaviruses: prospects for antiviral therapy.
Infection
MOV10 interacts with Enterovirus 71 genomic 5'UTR and modulates viral replication.
Infection
Novel biallelic TRNT1 mutations resulting in sideroblastic anemia, combined B and T cell defects, hypogammaglobulinemia, recurrent infections, hypertrophic cardiomyopathy and developmental delay.
Infection
Small-molecule inhibitors of bacterial AddAB and RecBCD helicase-nuclease DNA repair enzymes.
Infertility, Male
Gonadotropin-Regulated Testicular RNA helicase (GRTH/DDX25) a Multifunctional Protein Essential for Spermatogenesis.
Inflammatory Bowel Diseases
Increased expression of minichromosome maintenance protein 2 in active inflammatory bowel disease.
Insulin Resistance
Partial lipodystrophy with severe insulin resistance and adult progeria Werner syndrome.
Intellectual Disability
Human DNA Helicase B as a Candidate for Unwinding Secondary CGG Repeat Structures at the Fragile X Mental Retardation Gene.
Intellectual Disability
Novel mutations in WWOX, RARS2, and C10orf2 genes in consanguineous Arab families with intellectual disability.
Keratosis, Actinic
Expression of Minichromosome Maintenance Proteins in Actinic Keratosis and Squamous Cell Carcinoma.
Keratosis, Actinic
Minichromosome Maintenance Protein Expression According to the Grade of Atypism in Actinic Keratosis.
Kidney Calculi
Doppler artifacts and pitfalls.
Kidney Calculi
Relationship between Twinkle Artefacts and in vivo Biochemical Composition of Kidney Stones.
Kidney Neoplasms
ERCC6L, a DNA helicase, is involved in cell proliferation and associated with survival and progress in breast and kidney cancers.
Leukemia
Common genetic variants associated with telomere length confer risk for neuroblastoma and other childhood cancers.
Leukemia
MOV10 interacts with Enterovirus 71 genomic 5'UTR and modulates viral replication.
Leukemia
Promyelocytic leukemia protein interacts with werner syndrome helicase and regulates double-strand break repair in ?-irradiation-induced DNA damage responses.
Leukemia
WRN-targeted therapy using inhibitors NSC 19630 and NSC 617145 induce apoptosis in HTLV-1-transformed adult T-cell leukemia cells.
Leukemia, Lymphocytic, Chronic, B-Cell
RECQ helicases are deregulated in hematological malignancies in association with a prognostic value.
Leukemia, Myeloid, Acute
RECQ helicases are deregulated in hematological malignancies in association with a prognostic value.
Leukopenia
Germline polymorphisms in patients with advanced nonsmall cell lung cancer receiving first-line platinum-gemcitabine chemotherapy: A prospective clinical study.
Li-Fraumeni Syndrome
Genetically engineered mouse models and human osteosarcoma.
Lipodystrophy
Partial lipodystrophy with severe insulin resistance and adult progeria Werner syndrome.
Liver Diseases
Mitochondrial DNA Depletion Syndromes: Review and Updates of Genetic Basis, Manifestations, and Therapeutic Options.
Liver Diseases
Myelodysplasia and liver disease extend the spectrum of RTEL1 related telomeropathies.
Liver Failure
Next Generation Sequencing Facilitates The Diagnosis In A Child With Twinkle Mutations Causing Cholestatic Liver Failure.
Liver Neoplasms
Biological effects of lentivirus-mediated silencing of minichromosome maintenance protein 7 with shRNA on the liver cancer MHCC-97H cells.
Lung Diseases
Pulmonary phenotypes associated with genetic variation in telomere-related genes.
Lung Diseases, Interstitial
Rare Variants in RTEL1 Are Associated with Familial Interstitial Pneumonia.
Lung Diseases, Interstitial
Regulator of telomere length 1 (RTEL1) mutations are associated with heterogeneous pulmonary and extra-pulmonary phenotypes.
Lung Diseases, Interstitial
Three-dimensional spatial analysis of missense variants in RTEL1 identifies pathogenic variants in patients with Familial Interstitial Pneumonia.
Lung Neoplasms
Analysis of RTEL1 and PCDHGB6 promoter methylation in circulating-free DNA of lung cancer patients using liquid biopsy: A pilot study.
Lung Neoplasms
Effects of RECQ1 helicase silencing on non-small cell lung cancer cells.
Lung Neoplasms
Genome-wide association study of familial lung cancer.
Lung Neoplasms
Minichromosome Maintenance Protein 7 is a potential therapeutic target in human cancer and a novel prognostic marker of non-small cell lung cancer.
Lung Neoplasms
RTEL1 polymorphisms are associated with lung cancer risk in the Chinese Han population.
Lung Neoplasms
Telomere structure and maintenance gene variants and risk of five cancer types.
Lung Neoplasms
[Deguelin inhibits proliferation and regulates the expression of MCM3-CDC45 in MCF-7 and H1299 cells in vitro].
Lymphatic Metastasis
Construction and selection of subtracted cDNA library of mouse hepatocarcinoma cell lines with different lymphatic metastasis potential.
Lymphoma
FANCJ suppresses microsatellite instability and lymphomagenesis independent of the Fanconi anemia pathway.
Lymphoma
Minichromosome maintenance protein 6, a proliferation marker superior to Ki-67 and independent predictor of survival in patients with mantle cell lymphoma.
Lymphoma
RECQ helicases are deregulated in hematological malignancies in association with a prognostic value.
Lymphoma
The interaction between ATRIP and MCM complex is essential for ATRIP chromatin loading and its phosphorylation in mantle cell lymphoma cells.
Lymphoma
[Expression of Cdc7 and mcm2 as a marker for proliferation and prognosis in diffuse large B cell lymphoma].
Lymphoma, B-Cell
Expression of minichromosome maintenance protein 2 as a marker for proliferation and prognosis in diffuse large B-cell lymphoma: a tissue microarray and clinico-pathological analysis.
Lymphoma, B-Cell
[Expression of Cdc7 and mcm2 as a marker for proliferation and prognosis in diffuse large B cell lymphoma].
Lymphoma, Mantle-Cell
Minichromosome maintenance protein 6, a proliferation marker superior to Ki-67 and independent predictor of survival in patients with mantle cell lymphoma.
Lymphoma, Mantle-Cell
The interaction between ATRIP and MCM complex is essential for ATRIP chromatin loading and its phosphorylation in mantle cell lymphoma cells.
Lymphoma, Non-Hodgkin
Telomerase activity in B-cell non-Hodgkin lymphomas is regulated by hTERT transcription and correlated with telomere-binding protein expression but uncoupled from proliferation.
Malaria
Emerging importance of mismatch repair components including UvrD helicase and their cross-talk with the development of drug resistance in malaria parasite.
Malaria
Plasmodium falciparum DNA helicase 60. dsRNA- and antibody-mediated inhibition of malaria parasite growth and downregulation of its enzyme activities by DNA-interacting compounds.
Malaria
Replication fork-stimulated eIF-4A from Plasmodium cynomolgi unwinds DNA in the 3' to 5' direction and is inhibited by DNA-interacting compounds.
Medulloblastoma
Overexpression of minichromosome maintenance protein 10 in medulloblastoma and its clinical implications.
Medulloblastoma
The medulloblastoma cell line DAOY but not eleven other tumor cell lines expresses minichromosome maintenance protein 4.
Melanoma
Cell cycle analysis can differentiate thin melanomas from dysplastic nevi and reveals accelerated replication in thick melanomas.
Melanoma
FANCJ localization by mismatch repair is vital to maintain genomic integrity after UV irradiation.
Melanoma
Minichromosome maintenance protein expression in benign nevi, dysplastic nevi, melanoma, and cutaneous melanoma metastases.
Melanoma
On the interplay of telomeres, nevi and the risk of melanoma.
Meningioma
Search for mutations of the hRAD54 gene in sporadic meningiomas with deletion at 1p32.
Mesothelioma
Differential diagnosis of reactive mesothelial cells and malignant mesothelioma cells using the cell proliferation markers minichromosome maintenance protein 7, geminin, topoisomerase II alpha and Ki-67.
Mesothelioma
Immunohistochemical Evaluation of Minichromosome Maintenance Protein 7 (MCM7), Topoisomerase II?, and Ki-67 in Diffuse Malignant Peritoneal Mesothelioma Patients Using Tissue Microarray.
Microcephaly
Identification and biochemical characterization of a novel mutation in DDX11 causing Warsaw breakage syndrome.
Migraine Disorders
Migraine and epilepsy: A focus on overlapping clinical, pathophysiological, molecular, and therapeutic aspects.
Mitochondrial Diseases
A mitochondrial implication in a Tunisian patient with Friedreich's ataxia-like.
Mitochondrial Diseases
Adults with RRM2B-related mitochondrial disease have distinct clinical and molecular characteristics.
Mitochondrial Diseases
Defects of mitochondrial DNA replication.
Mitochondrial Diseases
Developmental and pathological changes in the human cardiac muscle mitochondrial DNA organization, replication and copy number.
Mitochondrial Diseases
Disease variants of the human mitochondrial DNA helicase encoded by C10orf2 differentially alter protein stability, nucleotide hydrolysis, and helicase activity.
Mitochondrial Diseases
Mitochondrial DNA homeostasis is essential for nigrostriatal integrity.
Mitochondrial Diseases
Modeling pathogenic mutations of human twinkle in Drosophila suggests an apoptosis role in response to mitochondrial defects.
Mitochondrial Diseases
Mutant mitochondrial helicase Twinkle causes multiple mtDNA deletions and a late-onset mitochondrial disease in mice.
Mitochondrial Diseases
POLG1 p.R722H mutation associated with multiple mtDNA deletions and a neurological phenotype.
Mitochondrial Diseases
Twinkle helicase is essential for mtDNA maintenance and regulates mtDNA copy number.
Mitochondrial Diseases
Twinkle, the mitochondrial replicative DNA helicase, is widespread in the eukaryotic radiation and may also be the mitochondrial DNA primase in most eukaryotes.
Mitochondrial Encephalomyopathies
Revisiting mitochondrial ocular myopathies: a study from the Italian Network.
Mitochondrial Myopathies
Affection of immune cells by a C10orf2 mutation manifesting as mitochondrial myopathy and transient sensory transverse syndrome.
Mitochondrial Myopathies
Inactivation of Pif1 helicase causes a mitochondrial myopathy in mice.
Mitochondrial Myopathies
Mesencephalic complex I deficiency does not correlate with parkinsonism in mitochondrial DNA maintenance disorders.
Mitochondrial Myopathies
Reply to the letter by Finsterer et al. concerning the paper: "Affection of immune-cells by a C10orf2 mutation manifesting as mitochondrial myopathy and transient sensory transverse syndrome" by Galassi G. et al.
Mitochondrial Myopathies
The hexameric structure of the human mitochondrial replicative helicase Twinkle.
Multiple Myeloma
RECQ helicases are deregulated in hematological malignancies in association with a prognostic value.
Multiple Myeloma
RECQ1 helicase is involved in replication stress survival and drug resistance in multiple myeloma.
Muscle Weakness
Mutation in TWINKLE in a Large Iranian Family with Progressive External Ophthalmoplegia, Myopathy, Dysphagia and Dysphonia, and Behavior Change.
Muscular Diseases
A novel variation in the Twinkle linker region causing late-onset dementia.
Muscular Diseases
Effect of bezafibrate treatment on late-onset mitochondrial myopathy in mice.
Muscular Diseases
Mild ocular myopathy associated with a novel mutation in mitochondrial twinkle helicase.
Muscular Diseases
Mitochondrial DNA Replication Defects Disturb Cellular dNTP Pools and Remodel One-Carbon Metabolism.
Muscular Diseases
Mutation in TWINKLE in a Large Iranian Family with Progressive External Ophthalmoplegia, Myopathy, Dysphagia and Dysphonia, and Behavior Change.
Muscular Diseases
Recessive C10orf2 mutations in a family with infantile-onset spinocerebellar ataxia, sensorimotor polyneuropathy, and myopathy.
Muscular Diseases
Revisiting mitochondrial ocular myopathies: a study from the Italian Network.
Myelodysplastic Syndromes
Genetic features of myelodysplastic syndrome and aplastic anemia in pediatric and young adult patients.
Myocardial Infarction
Twinkle overexpression prevents cardiac rupture after myocardial infarction by alleviating impaired mitochondrial biogenesis.
Neoplasm Metastasis
An appraisal of RECQ1 expression in cancer progression.
Neoplasm Metastasis
High Minichromosome maintenance protein 7 proliferation indices: a powerful predictor of progression in pancreatic neuroendocrine neoplasms without distant metastasis at the time of surgery.
Neoplasm Metastasis
Identification of RECQ1-regulated transcriptome uncovers a role of RECQ1 in regulation of cancer cell migration and invasion.
Neoplasm Metastasis
Minichromosome maintenance protein expression in benign nevi, dysplastic nevi, melanoma, and cutaneous melanoma metastases.
Neoplasm Metastasis
MiR-362-3p functions as a tumor suppressor through targeting MCM5 in cervical adenocarcinoma.
Neoplasms
A cascade leading to premature aging phenotypes including abnormal tumor profiles in Werner syndrome (review).
Neoplasms
A cocktail of MCM2 and TOP2A, p16INK4a and Ki-67 as biomarkers for the improved diagnosis of cervical intraepithelial lesion.
Neoplasms
A dominantly acting murine allele of Mcm4 causes chromosomal abnormalities and promotes tumorigenesis.
Neoplasms
A high-throughput screen to identify novel small molecule inhibitors of the Werner Syndrome Helicase-Nuclease (WRN).
Neoplasms
A new proliferation marker, minichromosome maintenance protein 2, is associated with tumor aggressiveness in esophageal squamous cell carcinoma.
Neoplasms
A polymorphism in Werner syndrome gene is associated with breast cancer susceptibility in Chinese women.
Neoplasms
A role for PML and the nuclear body in genomic stability.
Neoplasms
An appraisal of RECQ1 expression in cancer progression.
Neoplasms
An interaction network driven approach for identifying biomarkers for progressing cervical intraepithelial neoplasia.
Neoplasms
An MCM4 mutation detected in cancer cells affects MCM4/6/7 complex formation.
Neoplasms
Assessing the link between BACH1/FANCJ and MLH1 in DNA crosslink repair.
Neoplasms
Association between glioma susceptibility loci and tumour pathology defines specific molecular etiologies.
Neoplasms
Association of RECQL5 gene polymorphisms and osteosarcoma in a Chinese Han population.
Neoplasms
Association of the Bloom syndrome protein with topoisomerase IIIalpha in somatic and meiotic cells.
Neoplasms
Biology of osteogenic sarcoma.
Neoplasms
BLM promotes the activation of Fanconi Anemia signaling pathway.
Neoplasms
BLM unfolds G-quadruplexes in different structural environments through different mechanisms.
Neoplasms
Bovine papillomavirus type 1 E1 and simian virus 40 large T antigen share regions of sequence similarity required for multiple functions.
Neoplasms
BRCA1 and FancJ cooperatively promote interstrand crosslinker induced centrosome amplification through the activation of polo-like kinase 1.
Neoplasms
BRCA1-mediated repression of mutagenic end-joining of DNA double-strand breaks requires complex formation with BACH1.
Neoplasms
BRIP1 inhibits the tumorigenic properties of cervical cancer by regulating RhoA GTPase activity.
Neoplasms
BRIP1/FANCJ Mutation Analysis in a Family with History of Male and Female Breast Cancer in India.
Neoplasms
Catalytic strand separation by RECQ1 is required for RPA-mediated response to replication stress.
Neoplasms
Characterization of a new BLM mutation associated with a topoisomerase II alpha defect in a patient with Bloom's syndrome.
Neoplasms
Chromosome breakage syndromes and cancer.
Neoplasms
Chromosome instability and tumor predisposition inversely correlate with BLM protein levels.
Neoplasms
Comparison of minichromosome maintenance protein 7, Ki67 and mitotic index in the prognosis of intermediate Patnaik grade cutaneous mast cell tumours in dogs.
Neoplasms
Decreased FANCJ caused by 5FU contributes to the increased sensitivity to oxaliplatin in gastric cancer cells.
Neoplasms
Dephosphorylation and subcellular compartment change of the mitotic Bloom's syndrome DNA helicase in response to ionizing radiation.
Neoplasms
Depletion of minichromosome maintenance protein 7 inhibits glioblastoma multiforme tumor growth in vivo.
Neoplasms
Detection by epitope-defined monoclonal antibodies of Werner DNA helicases in the nucleoplasm and their upregulation by cell transformation and immortalization.
Neoplasms
Determination of potential cellular proliferation in the odontogenic epithelia of the dental follicle of the asymptomatic impacted third molars.
Neoplasms
Diagnosis of genito-urinary tract cancer by detection of minichromosome maintenance 5 protein in urine sediments.
Neoplasms
Diagnosis of oesophageal cancer by detection of minichromosome maintenance 5 protein in gastric aspirates.
Neoplasms
Diagnosis of pancreaticobiliary malignancy by detection of minichromosome maintenance protein 5 in bile aspirates.
Neoplasms
Diagnosis of pancreaticobiliary malignancy by detection of minichromosome maintenance protein 5 in biliary brush cytology.
Neoplasms
Digital expression profiling identifies RUNX2, CDC5L, MDM2, RECQL4, and CDK4 as potential predictive biomarkers for neo-adjuvant chemotherapy response in paediatric osteosarcoma.
Neoplasms
Digital imaging in the immunohistochemical evaluation of the proliferation markers Ki67, MCM2 and Geminin, in early breast cancer, and their putative prognostic value.
Neoplasms
Dimerization of simian virus 40 T-antigen hexamers activates T-antigen DNA helicase activity.
Neoplasms
DNA helicase activity of SV40 large tumor antigen.
Neoplasms
DNA helicase and nucleoside-5'-triphosphatase activities of polyoma virus large tumor antigen.
Neoplasms
DNA helicase deficiencies associated with cancer predisposition and premature ageing disorders.
Neoplasms
Does Immunohistochemistry for Discovered on GIST1 and Minichromosome Maintenance Protein7 Provide Additional Clinicopathological Value in Gastrointestinal Stromal Tumors?
Neoplasms
Drosophila BLM in double-strand break repair by synthesis-dependent strand annealing.
Neoplasms
Effect of a novel antibiotic, heliquinomycin, on DNA helicase and cell growth.
Neoplasms
Effect of an MCM4 mutation that causes tumours in mouse on human MCM4/6/7 complex formation.
Neoplasms
Effect of minichromosome maintenance protein 2 deficiency on the locations of DNA replication origins.
Neoplasms
Effect of Recql5 deficiency on the intestinal tumor susceptibility of Apc(min) mice.
Neoplasms
Effects of in vitro dephosphorylation on DNA-binding and DNA helicase activities of simian virus 40 large tumor antigen.
Neoplasms
Effects of RECQ1 helicase silencing on non-small cell lung cancer cells.
Neoplasms
Efficacy of Acylfulvene Illudin analogues against a metastatic lung carcinoma MV522 xenograft nonresponsive to traditional anticancer agents: retention of activity against various mdr phenotypes and unusual cytotoxicity against ERCC2 and ERCC3 DNA helicase-deficient cells.
Neoplasms
Embryonic stem cells deficient for Brca2 or Blm exhibit divergent genotoxic profiles that support opposing activities during homologous recombination.
Neoplasms
ERCC6L, a DNA helicase, is involved in cell proliferation and associated with survival and progress in breast and kidney cancers.
Neoplasms
Evaluation of Minichromosome Maintenance Protein 7 and c-KIT as Prognostic Markers in Feline Cutaneous Mast Cell Tumours.
Neoplasms
Expression of human MCM6 and DNA Topo II alpha in craniopharyngiomas and its correlation with recurrence of the tumor.
Neoplasms
Expression of Ku86 and presence of Ku86 antibody as biomarkers of hepatitis B virus related hepatocellular carcinoma.
Neoplasms
FANCJ helicase controls the balance between short- and long-tract gene conversions between sister chromatids.
Neoplasms
Fanconi Anemia Complementation Group FANCD2 Protein Serine 331 Phosphorylation Is Important for Fanconi Anemia Pathway Function and BRCA2 Interaction.
Neoplasms
Formation of deletions during double-strand break repair in Drosophila DmBlm mutants occurs after strand invasion.
Neoplasms
Further evidence for the contribution of the BRCA1-interacting protein-terminal helicase 1 (BRIP1) gene in breast cancer susceptibility.
Neoplasms
Generation of a mouse model for studying the role of upregulated RTEL1 activity in tumorigenesis.
Neoplasms
Genetic instability and cancer.
Neoplasms
Genetic Manipulation of Homologous Recombination In Vivo Attenuates Intestinal Tumorigenesis.
Neoplasms
Getting Ready for the Dance: FANCJ Irons Out DNA Wrinkles.
Neoplasms
HELQ reverses the malignant phenotype of osteosarcoma cells via CHK1-RAD51 signaling pathway.
Neoplasms
Hereditary breast cancer and the BRCA1-associated FANCJ/BACH1/BRIP1.
Neoplasms
High Minichromosome maintenance protein 7 proliferation indices: a powerful predictor of progression in pancreatic neuroendocrine neoplasms without distant metastasis at the time of surgery.
Neoplasms
Homozygosity for the WRN Helicase-Inactivating Variant, R834C, does not confer a Werner syndrome clinical phenotype.
Neoplasms
hRAD54 gene and 1p high-resolution deletion-mapping analyses in oligodendrogliomas.
Neoplasms
Human p53 directs DNA strand reassociation and is photolabelled by 8-azido ATP.
Neoplasms
Human RECQ Helicase Pathogenic Variants, Population Variation and "Missing" Diseases.
Neoplasms
Human RECQ helicases: Roles in DNA metabolism, mutagenesis and cancer biology.
Neoplasms
Human RECQ1 interacts with Ku70/80 and modulates DNA end-joining of double-strand breaks.
Neoplasms
Identification of human cancer-related genes by naturally occurring Hepatitis B Virus DNA tagging.
Neoplasms
Identification of RECQ1-regulated transcriptome uncovers a role of RECQ1 in regulation of cancer cell migration and invasion.
Neoplasms
Immunohistochemical Evaluation of Minichromosome Maintenance Protein 7 (MCM7), Topoisomerase II?, and Ki-67 in Diffuse Malignant Peritoneal Mesothelioma Patients Using Tissue Microarray.
Neoplasms
Immunohistochemical Expression of MCM-2 in Oral Epithelial Dysplasias.
Neoplasms
Increased chemotherapeutic activity of camptothecin in cancer cells by siRNA-induced silencing of WRN helicase.
Neoplasms
Increased levels of RECQ5 shift DNA repair from canonical to alternative pathways.
Neoplasms
Inhibition of helicase activity by a small molecule impairs Werner syndrome helicase (WRN) function in the cellular response to DNA damage or replication stress.
Neoplasms
Interaction of Werner and Bloom syndrome genes with p53 in familial breast cancer.
Neoplasms
Intra-nuclear trafficking of the BLM helicase to DNA damage-induced foci is regulated by SUMO modification.
Neoplasms
Isolation of human DNA-unwinding elements as sites of DNA polymerase alpha/primase entry.
Neoplasms
Isolation of stool-derived mucus provides a high yield of colonocytes suitable for early detection of colorectal carcinoma.
Neoplasms
KSHV de-regulates host cellular replication during lytic reactivation by disrupting the MCM complex through ORF59.
Neoplasms
Longevity mutation in SCH9 prevents recombination errors and premature genomic instability in a Werner/Bloom model system.
Neoplasms
MCM proteins as diagnostic and prognostic tumor markers in the clinical setting.
Neoplasms
Mcm2 predicts recurrence hazard in stage Ta/T1 bladder cancer more accurately than CK20, Ki67 and histological grade.
Neoplasms
MCM2-regulated functional networks in lung cancer by multi-dimensional proteomic approach.
Neoplasms
MCM3 Protein Expression in Follicular and Classical Variants of Papillary Thyroid Carcinoma.
Neoplasms
MCM7 expression predicts post-operative prognosis for hepatocellular carcinoma.
Neoplasms
MCM7 polymorphisms associated with the AML relapse and overall survival.
Neoplasms
Minichromosome maintenance helicase paralog MCM9 is dispensible for DNA replication but functions in germ-line stem cells and tumor suppression.
Neoplasms
Minichromosome maintenance protein (MCM6) in low-grade chondrosarcoma: distinction from enchondroma and identification of progressive tumors.
Neoplasms
Minichromosome maintenance protein 2 correlates with the malignant status and regulates proliferation and cell cycle in lung squamous cell carcinoma.
Neoplasms
Minichromosome maintenance protein 2 expression in normal kidney and renal cell carcinomas: relationship to tumor dormancy and potential clinical utility.
Neoplasms
Minichromosome maintenance protein 2 expression in prostate: characterization and association with outcome after therapy for cancer.
Neoplasms
Minichromosome maintenance protein 3 elicits a cancer-restricted immune response in patients with brain malignancies and is a strong independent predictor of survival in patients with anaplastic astrocytoma.
Neoplasms
Minichromosome maintenance protein 7 as prognostic marker of tumor aggressiveness in pituitary adenoma patients.
Neoplasms
Minichromosome Maintenance Protein 7 is a potential therapeutic target in human cancer and a novel prognostic marker of non-small cell lung cancer.
Neoplasms
Minichromosome maintenance protein expression in benign nevi, dysplastic nevi, melanoma, and cutaneous melanoma metastases.
Neoplasms
Minichromosome maintenance protein in myxofibrosarcoma.
Neoplasms
Model system for DNA replication of a plasmid DNA containing the autonomously replicating sequence from Saccharomyces cerevisiae.
Neoplasms
Molecular and cellular functions of the FANCJ DNA helicase defective in cancer and in Fanconi anemia.
Neoplasms
Molecular biology of Werner syndrome.
Neoplasms
Morphological and immunohistological characteristics of follicular-compact thyroid carcinoma in dog.
Neoplasms
Multiple functions of Drosophila BLM helicase in maintenance of genome stability.
Neoplasms
Multiple genetic pathways involving the Caenorhabditis elegans Bloom's syndrome genes him-6, rad-51, and top-3 are needed to maintain genome stability in the germ line.
Neoplasms
Mutagenic capacity of endogenous G4 DNA underlies genome instability in FANCJ-defective C. elegans.
Neoplasms
Mutation analysis of the RECQL4 gene in sporadic osteosarcomas.
Neoplasms
Mutation of the murine Bloom's syndrome gene produces global genome destabilization.
Neoplasms
Mutational analysis of the breast cancer susceptibility gene BRIP1 /BACH1/FANCJ in high-risk non-BRCA1/BRCA2 breast cancer families.
Neoplasms
Mutations in DNA replication genes reduce yeast life span.
Neoplasms
Overexpression and role of the ATPase and putative DNA helicase RuvB-like 2 in human hepatocellular carcinoma.
Neoplasms
Overexpression of the BRIP1 ameliorates chemosensitivity to cisplatin by inhibiting Rac1 GTPase activity in cervical carcinoma HeLa cells.
Neoplasms
Oxidative stress in Fanconi anaemia: from cells and molecules toward prospects in clinical management.
Neoplasms
Oxidative stress in Fanconi anaemia: from cells and molecules towards prospects in clinical management.
Neoplasms
p53 modulates RPA-dependent and RPA-independent WRN helicase activity.
Neoplasms
p53-catalyzed annealing of complementary single-stranded nucleic acids.
Neoplasms
p53-mediated apoptosis is attenuated in Werner syndrome cells.
Neoplasms
Partial proteolysis of simian virus 40 T antigen reveals intramolecular contacts between domains and conformation changes upon hexamer assembly.
Neoplasms
Pif1 helicase and Pol? promote recombination-coupled DNA synthesis via bubble migration.
Neoplasms
Possible anti-recombinogenic role of Bloom's syndrome helicase in double-strand break processing.
Neoplasms
Potential role of minichromosome maintenance protein 2 as a screening biomarker in esophageal cancer high-risk population in China.
Neoplasms
Problem-solving test: analysis of DNA damage recognizing proteins in yeast and human cells.
Neoplasms
Prognostic factors for anaplastic astrocytomas.
Neoplasms
Proliferation and apoptosis of tumour cells before and after neoadjuvant therapy for high-grade extremity sarcomas: divergent associations with tumour response and prognosis.
Neoplasms
Promotion and regulation of homologous recombination by DNA helicases.
Neoplasms
Protein expression of BLM gene and its apoptosis sensitivity in hematopoietic tumor cell strains.
Neoplasms
Protein kinase A subunit expression is altered in Bloom syndrome fibroblasts and the BLM protein is increased in adrenocortical hyperplasias: inverse findings for BLM and PRKAR1A.
Neoplasms
Proteomic and Mitochondrial Genomic Analyses of Pediatric Brain Tumors.
Neoplasms
Recognition of model DNA replication forks by the SV40 large tumor antigen.
Neoplasms
RecQ helicases and topoisomerases: implications for genome stability in humans.
Neoplasms
RecQ helicases: multiple roles in genome maintenance.
Neoplasms
RECQ1 expression is upregulated in response to DNA damage and in a p53-dependent manner.
Neoplasms
RECQ1 Helicase Silencing Decreases the Tumour Growth Rate of U87 Glioblastoma Cell Xenografts in Zebrafish Embryos.
Neoplasms
RECQL1 and WRN DNA repair helicases: potential therapeutic targets and proliferative markers against cancers.
Neoplasms
RECQL4 Promotes DNA End Resection in Repair of DNA Double-Strand Breaks.
Neoplasms
Replication protein A stimulates the werner syndrome protein branch migration activity.
Neoplasms
Resection Activity of the Sgs1 Helicase Alters the Affinity of DNA Ends for Homologous Recombination Proteins in Saccharomyces cerevisiae.
Neoplasms
Role for the Werner syndrome protein in the promotion of tumor cell growth.
Neoplasms
Role of Werner syndrome gene product helicase in carcinogenesis and in resistance to genotoxins by cancer cells.
Neoplasms
Roles of the Werner syndrome RecQ helicase in DNA replication.
Neoplasms
RTEL1 is a replisome-associated helicase that promotes telomere and genome-wide replication.
Neoplasms
RTEL1 maintains genomic stability by suppressing homologous recombination.
Neoplasms
RTEL1 polymorphisms are associated with lung cancer risk in the Chinese Han population.
Neoplasms
RTEL1: functions of a disease-associated helicase.
Neoplasms
Search for mutations of the hRAD54 gene in sporadic meningiomas with deletion at 1p32.
Neoplasms
Sgs1 function in the repair of DNA replication intermediates is separable from its role in homologous recombinational repair.
Neoplasms
shRNA knockdown of DNA helicase ERCC6L expression inhibits human breast cancer growth.
Neoplasms
Significance of DNA Replication Licensing Proteins (MCM2, MCM5 and CDC6), p16 and p63 as Markers of Premalignant Lesions of the Uterine Cervix: Its Usefulness to Predict Malignant Potential
Neoplasms
Simian virus 40 T-antigen DNA helicase is a hexamer which forms a binary complex during bidirectional unwinding from the viral origin of DNA replication.
Neoplasms
Site-directed mutants of human RECQ1 reveal functional importance of the zinc binding domain.
Neoplasms
Strand exchange of telomeric DNA catalyzed by the Werner syndrome protein (WRN) is specifically stimulated by TRF2.
Neoplasms
Structural basis for cell cycle checkpoint control by the BRCA1-CtIP complex.
Neoplasms
Structure of the BRCT repeats of BRCA1 bound to a BACH1 phosphopeptide: implications for signaling.
Neoplasms
Suppression of Apoptosis by PIF1 Helicase in Human Tumor Cells.
Neoplasms
Suppression of Reserve MCM Complexes Chemosensitizes to Gemcitabine and 5-Fluorouracil.
Neoplasms
Switch on the engine: how the eukaryotic replicative helicase MCM2-7 becomes activated.
Neoplasms
Targeted inhibition of WRN helicase, replication stress and cancer.
Neoplasms
Targeting an Achilles' heel of cancer with a WRN helicase inhibitor.
Neoplasms
Targeting the FANCJ-BRCA1 interaction promotes a switch from recombination to poleta-dependent bypass.
Neoplasms
Telomerase deficiency and cancer susceptibility syndromes.
Neoplasms
Telomere instability in a human tumor cell line expressing a dominant-negative WRN protein.
Neoplasms
Termination complex in Escherichia coli inhibits SV40 DNA replication in vitro by impeding the action of T antigen helicase.
Neoplasms
The Bloom's syndrome helicase (BLM) interacts physically and functionally with p12, the smallest subunit of human DNA polymerase delta.
Neoplasms
The Bloom's syndrome helicase suppresses crossing over during homologous recombination.
Neoplasms
The BRCA1-interacting helicase BRIP1 is deficient in Fanconi anemia.
Neoplasms
The broken genome: genetic and pharmacologic approaches to breaking DNA.
Neoplasms
The conserved core enzymatic activities and the distinct dynamics of polyomavirus large T antigens.
Neoplasms
The FANCJ/MutLalpha interaction is required for correction of the cross-link response in FA-J cells.
Neoplasms
The fission yeast BLM homolog Rqh1 promotes meiotic recombination.
Neoplasms
The helicase and ATPase activities of RECQL4 are compromised by mutations reported in three human patients.
Neoplasms
The human RECQ1 helicase is highly expressed in glioblastoma and plays an important role in tumor cell proliferation.
Neoplasms
The MCM complex: its role in DNA replication and implications for cancer therapy.
Neoplasms
The medulloblastoma cell line DAOY but not eleven other tumor cell lines expresses minichromosome maintenance protein 4.
Neoplasms
The prognostic potential of keratin 18 in breast cancer associated with tumor dedifferentiation, and the loss of estrogen and progesterone receptors.
Neoplasms
The Set2-RPB1-interaction domain of human RECQ5 is important for transcription-associated genome stability.
Neoplasms
The unwinding of duplex regions in DNA by the simian virus 40 large tumor antigen-associated DNA helicase activity.
Neoplasms
The Werner syndrome protein functions in repair of Cr(VI)-induced replication-associated DNA damage.
Neoplasms
Transcriptional induction of minichromosome maintenance protein 7 (Mcm7) in human cholangiocarcinoma cells treated with Clonorchis sinensis excretory-secretory products.
Neoplasms
Transcriptome guided identification of novel functions of RECQ1 helicase.
Neoplasms
Understanding the roles of RecQ helicases in the maintenance of genome integrity and suppression of tumorigenesis.
Neoplasms
Unraveling a connection between DNA demethylation repair and cancer.
Neoplasms
Welcome the family of FANCJ-like helicases to the block of genome stability maintenance proteins.
Neoplasms
Werner syndrome and the function of the Werner protein; what they can teach us about the molecular aging process.
Neoplasms
Werner syndrome helicase has a critical role in DNA damage responses in the absence of a functional fanconi anemia pathway.
Neoplasms
Werner syndrome protein suppresses the formation of large deletions during the replication of human telomeric sequences.
Neoplasms
Werner's syndrome as a hereditary risk factor for exocrine pancreatic cancer: Potential role of WRN in pancreatic tumorigenesis and patient-tailored therapy.
Neoplasms
When transcription meets recombination: a lesson from the human RECQ protein complexes.
Neoplasms
WRN functions in a RAD18-dependent damage avoidance pathway.
Neoplasms
Yeast as a model system to study RecQ helicase function.
Neoplasms
[Preparation, characterization and application of monoclonal antibody against RecQ helicase].
Neuroblastoma
Common genetic variants associated with telomere length confer risk for neuroblastoma and other childhood cancers.
Neuroblastoma
Minichromosome Maintenance Complex Is a Critical Node in the miR-183 Signaling Network of MYCN-Amplified Neuroblastoma Cells.
Neuroblastoma
Minichromosome maintenance protein MCM7 is a direct target of the MYCN transcription factor in neuroblastoma.
Neurodegenerative Diseases
Infantile-onset spinocerebellar ataxia and mitochondrial recessive ataxia syndrome are associated with neuronal complex I defect and mtDNA depletion.
Neurodegenerative Diseases
Novel Autosomal Recessive c10orf2 Mutations Causing Infantile-Onset Spinocerebellar Ataxia.
Neurologic Manifestations
Mesencephalic complex I deficiency does not correlate with parkinsonism in mitochondrial DNA maintenance disorders.
Neuromuscular Diseases
The Human Mitochondrial DNA helicase TWINKLE is both an unwinding and an annealing helicase.
Nevus
Minichromosome maintenance protein expression in benign nevi, dysplastic nevi, melanoma, and cutaneous melanoma metastases.
Nevus
On the interplay of telomeres, nevi and the risk of melanoma.
Nijmegen Breakage Syndrome
Werner syndrome protein associates with gamma H2AX in a manner that depends upon Nbs1.
Ophthalmoplegia
ANT1, Twinkle, POLG, and TP: new genes open our eyes to ophthalmoplegia.
Ophthalmoplegia
Encephalomyopathies caused by abnormal nuclear-mitochondrial intergenomic cross-talk.
Ophthalmoplegia
Familial parkinsonism and ophthalmoplegia from a mutation in the mitochondrial DNA helicase twinkle.
Ophthalmoplegia
Molecular analysis of ANT1, TWINKLE and POLG in patients with multiple deletions or depletion of mitochondrial DNA by a dHPLC-based assay.
Ophthalmoplegia
SANDO: Two novel mutations in POLG1 gene.
Ophthalmoplegia
Twinkle mutation in an Italian family with external progressive ophthalmoplegia and parkinsonism: A case report and an update on the state of art.
Ophthalmoplegia, Chronic Progressive External
A novel missense adenine nucleotide translocator-1 gene mutation in a Greek adPEO family.
Ophthalmoplegia, Chronic Progressive External
A novel Twinkle gene mutation in autosomal dominant progressive external ophthalmoplegia.
Ophthalmoplegia, Chronic Progressive External
A novel variation in the Twinkle linker region causing late-onset dementia.
Ophthalmoplegia, Chronic Progressive External
Abnormal Glycosylation Profile and High Alpha-Fetoprotein in a Patient with Twinkle Variants.
Ophthalmoplegia, Chronic Progressive External
Autosomal dominant mutations in POLG and C10orf2: association with late onset chronic progressive external ophthalmoplegia and Parkinsonism in two patients.
Ophthalmoplegia, Chronic Progressive External
C10ORF2 mutation associated with progressive external ophthalmoplegia and clinically isolated syndrome.
Ophthalmoplegia, Chronic Progressive External
Clinical and molecular features of adPEO due to mutations in the Twinkle gene.
Ophthalmoplegia, Chronic Progressive External
Clinical phenotype of autosomal dominant progressive external ophthalmoplegia in a family with a novel mutation in the C10orf2 gene.
Ophthalmoplegia, Chronic Progressive External
Defects of intergenomic communication: autosomal disorders that cause multiple deletions and depletion of mitochondrial DNA.
Ophthalmoplegia, Chronic Progressive External
Differential phenotypes of active site and human autosomal dominant progressive external ophthalmoplegia mutations in Drosophila mitochondrial DNA helicase expressed in Schneider cells.
Ophthalmoplegia, Chronic Progressive External
Disease variants of the human mitochondrial DNA helicase encoded by C10orf2 differentially alter protein stability, nucleotide hydrolysis, and helicase activity.
Ophthalmoplegia, Chronic Progressive External
Familial parkinsonism and ophthalmoplegia from a mutation in the mitochondrial DNA helicase twinkle.
Ophthalmoplegia, Chronic Progressive External
Finding twinkle in the eyes of a 71-year-old lady: a case report and review of the genotypic and phenotypic spectrum of TWINKLE-related dominant disease.
Ophthalmoplegia, Chronic Progressive External
Human mitochondrial DNA deletions associated with mutations in the gene encoding Twinkle, a phage T7 gene 4-like protein localized in mitochondria.
Ophthalmoplegia, Chronic Progressive External
Investigation on mtDNA deletions and twinkle gene mutation (G1423C) in Iranian patients with chronic progressive external opthalmoplagia.
Ophthalmoplegia, Chronic Progressive External
Levodopa response in Parkinsonism with multiple mitochondrial DNA deletions.
Ophthalmoplegia, Chronic Progressive External
Modeling pathogenic mutations of human twinkle in Drosophila suggests an apoptosis role in response to mitochondrial defects.
Ophthalmoplegia, Chronic Progressive External
Mutant mitochondrial helicase Twinkle causes multiple mtDNA deletions and a late-onset mitochondrial disease in mice.
Ophthalmoplegia, Chronic Progressive External
Mutation in TWINKLE in a Large Iranian Family with Progressive External Ophthalmoplegia, Myopathy, Dysphagia and Dysphonia, and Behavior Change.
Ophthalmoplegia, Chronic Progressive External
Mutation of OPA1 causes dominant optic atrophy with external ophthalmoplegia, ataxia, deafness and multiple mitochondrial DNA deletions: a novel disorder of mtDNA maintenance.
Ophthalmoplegia, Chronic Progressive External
Mutations of ANT1, Twinkle, and POLG1 in sporadic progressive external ophthalmoplegia (PEO).
Ophthalmoplegia, Chronic Progressive External
Neurodegenerative parkinsonism and progressive external ophthalmoplegia with a Twinkle mutation.
Ophthalmoplegia, Chronic Progressive External
Novel mutation in C10orf2 associated with multiple mtDNA deletions, chronic progressive external ophthalmoplegia and premature aging.
Ophthalmoplegia, Chronic Progressive External
Novel Twinkle (PEO1) gene mutations in mendelian progressive external ophthalmoplegia.
Ophthalmoplegia, Chronic Progressive External
Novel Twinkle gene mutation in autosomal dominant progressive external ophthalmoplegia and multisystem failure.
Ophthalmoplegia, Chronic Progressive External
Orthostatic Tremor, Progressive External Ophthalmoplegia, and Twinkle.
Ophthalmoplegia, Chronic Progressive External
POLG1, C10ORF2, and ANT1 mutations are uncommon in sporadic progressive external ophthalmoplegia with multiple mitochondrial DNA deletions.
Ophthalmoplegia, Chronic Progressive External
Progressive external ophthalmoplegia (PEO) due to a mutation in the C10orf2 (PEO1) gene mimicking a myasthenic crisis.
Ophthalmoplegia, Chronic Progressive External
Recessive Twinkle mutations in early onset encephalopathy with mtDNA depletion.
Ophthalmoplegia, Chronic Progressive External
Reconstitution of a minimal mtDNA replisome in vitro.
Ophthalmoplegia, Chronic Progressive External
Remarkable infidelity of polymerase gammaA associated with mutations in POLG1 exonuclease domain.
Ophthalmoplegia, Chronic Progressive External
Sensory ataxic neuropathy due to a novel C10Orf2 mutation with probable germline mosaicism.
Ophthalmoplegia, Chronic Progressive External
SLC25A4 and C10ORF2 Mutations in Autosomal Dominant Progressive External Ophthalmoplegia.
Ophthalmoplegia, Chronic Progressive External
Structure-function defects of the twinkle amino-terminal region in progressive external ophthalmoplegia.
Ophthalmoplegia, Chronic Progressive External
Structure-function defects of the TWINKLE linker region in progressive external ophthalmoplegia.
Ophthalmoplegia, Chronic Progressive External
The accessory subunit B of DNA polymerase gamma is required for mitochondrial replisome function.
Ophthalmoplegia, Chronic Progressive External
The clinical, histochemical, and molecular spectrum of PEO1 (Twinkle)-linked adPEO.
Ophthalmoplegia, Chronic Progressive External
TWINKLE gene mutation: report of a French family with an autosomal dominant progressive external ophthalmoplegia and literature review.
Ophthalmoplegia, Chronic Progressive External
TWINKLE Has 5' -> 3' DNA helicase activity and is specifically stimulated by mitochondrial single-stranded DNA-binding protein.
Ophthalmoplegia, Chronic Progressive External
Twinkle helicase (PEO1) gene mutation causes mitochondrial DNA depletion.
Ophthalmoplegia, Chronic Progressive External
Twinkle helicase is essential for mtDNA maintenance and regulates mtDNA copy number.
Ophthalmoplegia, Chronic Progressive External
Twinkle mutation in an Italian family with external progressive ophthalmoplegia and parkinsonism: A case report and an update on the state of art.
Ophthalmoplegia, Chronic Progressive External
Twinkle mutations associated with autosomal dominant progressive external ophthalmoplegia lead to impaired helicase function and in vivo mtDNA replication stalling.
Ophthalmoplegia, Chronic Progressive External
Twinkle mutations in two Chinese families with autosomal dominant progressive external ophthalmoplegia.
Ophthalmoplegia, Chronic Progressive External
Twinkle, the mitochondrial replicative DNA helicase, is widespread in the eukaryotic radiation and may also be the mitochondrial DNA primase in most eukaryotes.
Ophthalmoplegia, Chronic Progressive External
[Mitochondrial dysfunction in bipolar disorder]
Osteosarcoma
Common genetic variants associated with telomere length confer risk for neuroblastoma and other childhood cancers.
Osteosarcoma
Genetically engineered mouse models and human osteosarcoma.
Osteosarcoma
Minichromosome maintenance protein 2 and 3 promote osteosarcoma progression via DHX9 and predict poor patient prognosis.
Osteosarcoma
Mutation analysis of the RECQL4 gene in sporadic osteosarcomas.
Osteosarcoma
Nuclear import and retention domains in the amino terminus of RECQL4.
Osteosarcoma
The DNA helicase recql4 is required for normal osteoblast expansion and osteosarcoma formation.
Ovarian Neoplasms
Analysis of gene expression in early-stage ovarian cancer.
Ovarian Neoplasms
Ataxia-Telangiectasia and RAD3-Related and Ataxia-Telangiectasia-Mutated Proteins in Epithelial Ovarian Carcinoma: Their Expression and Clinical Significance.
Ovarian Neoplasms
Chl1 DNA Helicase Regulates Scc2 Deposition Specifically during DNA-Replication in Saccharomyces cerevisiae.
Ovarian Neoplasms
CtIP- and ATR-dependent FANCJ phosphorylation in response to DNA strand breaks mediated by DNA replication.
Ovarian Neoplasms
FANCJ helicase controls the balance between short- and long-tract gene conversions between sister chromatids.
Ovarian Neoplasms
Fanconi anemia: a model disease for studies on human genetics and advanced therapeutics.
Ovarian Neoplasms
HP1 regulates the localization of FANCJ at sites of DNA double-strand breaks.
Ovarian Neoplasms
Insight into the Roles of Helicase Motif Ia by Characterizing Fanconi Anemia Group J Protein (FANCJ) Patient Mutations.
Ovarian Neoplasms
Molecular and cellular functions of the FANCJ DNA helicase defective in cancer and in Fanconi anemia.
Ovarian Neoplasms
Mutational analysis of FANCJ helicase.
Ovarian Neoplasms
No evidence of involvement of germline BACH1 mutations in Finnish breast and ovarian cancer families.
Ovarian Neoplasms
Opposing Roles of FANCJ and HLTF Protect Forks and Restrain Replication during Stress.
Ovarian Neoplasms
RECQL1 DNA Repair Helicase: A Potential Therapeutic Target and a Proliferative Marker against Ovarian Cancer.
Ovarian Neoplasms
Structure-function analysis of DNA helicase HELQ: A new diagnostic marker in ovarian cancer.
Pancreatic Neoplasms
RECQ1 A159C Polymorphism Is Associated With Overall Survival of Patients With Resected Pancreatic Cancer: A Replication Study in NRG Oncology Radiation Therapy Oncology Group 9704.
Pancreatic Neoplasms
Single nucleotide polymorphisms of RecQ1, RAD54L, and ATM genes are associated with reduced survival of pancreatic cancer.
Papilloma
The cellular DNA polymerase alpha-primase is required for papillomavirus DNA replication and associates with the viral E1 helicase.
Papilloma
The E1 protein of bovine papilloma virus 1 is an ATP-dependent DNA helicase.
Parkinson Disease
Familial parkinsonism and ophthalmoplegia from a mutation in the mitochondrial DNA helicase twinkle.
Parkinsonian Disorders
Autosomal dominant mutations in POLG and C10orf2: association with late onset chronic progressive external ophthalmoplegia and Parkinsonism in two patients.
Parkinsonian Disorders
Familial parkinsonism and ophthalmoplegia from a mutation in the mitochondrial DNA helicase twinkle.
Parkinsonian Disorders
Mesencephalic complex I deficiency does not correlate with parkinsonism in mitochondrial DNA maintenance disorders.
Parkinsonian Disorders
Mutant Twinkle increases dopaminergic neurodegeneration, mtDNA deletions and modulates Parkin expression.
Parkinsonian Disorders
Mutation in TWINKLE in a Large Iranian Family with Progressive External Ophthalmoplegia, Myopathy, Dysphagia and Dysphonia, and Behavior Change.
Parkinsonian Disorders
Neurodegenerative parkinsonism and progressive external ophthalmoplegia with a Twinkle mutation.
Parkinsonian Disorders
Twinkle mutation in an Italian family with external progressive ophthalmoplegia and parkinsonism: A case report and an update on the state of art.
Peripheral Nervous System Diseases
Mutation in TWINKLE in a Large Iranian Family with Progressive External Ophthalmoplegia, Myopathy, Dysphagia and Dysphonia, and Behavior Change.
Pituitary Neoplasms
Minichromosome maintenance protein 7 as prognostic marker of tumor aggressiveness in pituitary adenoma patients.
Polyneuropathies
Recessive C10orf2 mutations in a family with infantile-onset spinocerebellar ataxia, sensorimotor polyneuropathy, and myopathy.
Progeria
Association of epigenetic inactivation of the WRN gene with anticancer drug sensitivity in cervical cancer cells.
Progeria
p38 (MAPK) stress signalling in replicative senescence in fibroblasts from progeroid and genomic instability syndromes.
Progeria
RECQ helicase disease and related progeroid syndromes: RECQ2018 meeting.
Progeria
Serines 440 and 467 in the Werner syndrome protein are phosphorylated by DNA-PK and affects its dynamics in response to DNA double strand breaks.
Progeria
Werner complex deficiency in cells disrupts the Nuclear Pore Complex and the distribution of lamin B1.
Prostatic Neoplasms
Green tea catechins suppress the DNA synthesis marker MCM7 in the TRAMP model of prostate cancer.
Prostatic Neoplasms
Histopathological variables and biomarkers enhancer of zeste homologue 2, Ki-67 and minichromosome maintenance protein 7 as prognosticators in primarily endocrine-treated prostate cancer.
Prostatic Neoplasms
RecQ helicase BLM regulates prostate cancer cell proliferation and apoptosis.
Prostatic Neoplasms
Regulation of minichromosome maintenance gene family by microRNA-1296 and genistein in prostate cancer.
Protein Deficiency
Aging stem cells. A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging.
Protein Deficiency
Effect of minichromosome maintenance protein 2 deficiency on the locations of DNA replication origins.
Protein Deficiency
WRN regulates pathway choice between classical and alternative non-homologous end joining.
Pulmonary Disease, Chronic Obstructive
Association between RTEL1 gene polymorphisms and COPD susceptibility in a Chinese Han population.
Pulmonary Disease, Chronic Obstructive
Multistudy fine mapping of chromosome 2q identifies XRCC5 as a chronic obstructive pulmonary disease susceptibility gene.
Pulmonary Fibrosis
Exome sequencing links mutations in PARN and RTEL1 with familial pulmonary fibrosis and telomere shortening.
Pulmonary Fibrosis
Heterozygous RTEL1 mutations are associated with familial pulmonary fibrosis.
Pulmonary Fibrosis
Regulator of telomere length 1 (RTEL1) mutations are associated with heterogeneous pulmonary and extra-pulmonary phenotypes.
Pulmonary Fibrosis
Telomeres revisited: RTEL1 variants in pulmonary fibrosis.
Pulmonary Fibrosis
The molecular genetics of the telomere biology disorders.
rada recombinase deficiency
The Bloom syndrome protein limits the lethality associated with RAD51 deficiency.
Respiratory Insufficiency
TWINKLE gene mutation: report of a French family with an autosomal dominant progressive external ophthalmoplegia and literature review.
Retinitis Pigmentosa
Hypomorphic mutations in TRNT1 cause retinitis pigmentosa with erythrocytic microcytosis.
Retinoblastoma
Genetically engineered mouse models and human osteosarcoma.
Retinoblastoma
Requirement for p38 mitogen-activated protein kinase activity in neointima formation after vascular injury.
Rheumatic Diseases
Clinical and serological associations of autoantibodies to the Ku70/Ku80 heterodimer determined by a novel chemiluminescent immunoassay.
RNA Virus Infections
DEAD-Box Helicase DDX25 Is a Negative Regulator of Type I Interferon Pathway and Facilitates RNA Virus Infection.
Rothmund-Thomson Syndrome
Cloning, genomic structure and chromosomal localization of the gene encoding mouse DNA helicase RecQ helicase protein-like 4.
Rothmund-Thomson Syndrome
Direct and indirect roles of RECQL4 in modulating base excision repair capacity.
Rothmund-Thomson Syndrome
Drosophila melanogaster RECQ5/QE DNA helicase: stimulation by GTP binding.
Rothmund-Thomson Syndrome
Elevated incidence of loss of heterozygosity (LOH) in an sgs1 mutant of Saccharomyces cerevisiae: roles of yeast RecQ helicase in suppression of aneuploidy, interchromosomal rearrangement, and the simultaneous incidence of both events during mitotic growth.
Rothmund-Thomson Syndrome
Genetically engineered mouse models and human osteosarcoma.
Rothmund-Thomson Syndrome
Mutation analysis of the RECQL4 gene in sporadic osteosarcomas.
Rothmund-Thomson Syndrome
Nuclear import and retention domains in the amino terminus of RECQL4.
Rothmund-Thomson Syndrome
Recombination-mediated lengthening of terminal telomeric repeats requires the Sgs1 DNA helicase.
Rothmund-Thomson Syndrome
RECQ DNA helicases and osteosarcoma.
Rothmund-Thomson Syndrome
RECQL4 Promotes DNA End Resection in Repair of DNA Double-Strand Breaks.
Rothmund-Thomson Syndrome
RECQL4, the protein mutated in Rothmund-Thomson syndrome, functions in telomere maintenance.
Rothmund-Thomson Syndrome
Senescence induced by RECQL4 dysfunction contributes to Rothmund-Thomson syndrome features in mice.
Rothmund-Thomson Syndrome
The Rothmund-Thomson syndrome helicase RECQL4 is essential for hematopoiesis.
Sarcoma
Nucleolar localization of the Werner syndrome protein in human cells.
Sarcoma
Prognostic significance of Minichromosome maintenance protein 7 and Geminin expression in patients with 109 soft tissue sarcomas.
Scleroderma, Systemic
Altered MCM Protein Levels and Autophagic Flux in Aged and Systemic Sclerosis Dermal Fibroblasts.
Scotoma
Illusory stimuli can be used to identify retinal blind spots.
Skin Neoplasms
FANCJ localization by mismatch repair is vital to maintain genomic integrity after UV irradiation.
Skin Neoplasms
G364R mutation of MCM4 detected in human skin cancer cells affects DNA helicase activity of MCM4/6/7 complex.
Spinocerebellar Ataxias
Abnormal Glycosylation Profile and High Alpha-Fetoprotein in a Patient with Twinkle Variants.
Spinocerebellar Ataxias
Disease variants of the human mitochondrial DNA helicase encoded by C10orf2 differentially alter protein stability, nucleotide hydrolysis, and helicase activity.
Spinocerebellar Ataxias
Identification of a novel twinkle mutation in a family with infantile onset spinocerebellar ataxia by whole exome sequencing.
Spinocerebellar Ataxias
Infantile onset spinocerebellar ataxia caused by compound heterozygosity for Twinkle mutations and modeling of Twinkle mutations causing recessive disease.
Spinocerebellar Ataxias
Infantile onset spinocerebellar ataxia is caused by recessive mutations in mitochondrial proteins Twinkle and Twinky.
Spinocerebellar Ataxias
Infantile-onset spinocerebellar ataxia and mitochondrial recessive ataxia syndrome are associated with neuronal complex I defect and mtDNA depletion.
Spinocerebellar Ataxias
Mesencephalic complex I deficiency does not correlate with parkinsonism in mitochondrial DNA maintenance disorders.
Spinocerebellar Ataxias
Mitochondrial DNA Replication Defects Disturb Cellular dNTP Pools and Remodel One-Carbon Metabolism.
Spinocerebellar Ataxias
Novel Autosomal Recessive c10orf2 Mutations Causing Infantile-Onset Spinocerebellar Ataxia.
Spinocerebellar Ataxias
Recessive C10orf2 mutations in a family with infantile-onset spinocerebellar ataxia, sensorimotor polyneuropathy, and myopathy.
Spinocerebellar Ataxias
Recessive twinkle mutations cause severe epileptic encephalopathy.
Spinocerebellar Ataxias
Recessive Twinkle mutations in early onset encephalopathy with mtDNA depletion.
Spinocerebellar Ataxias
Twinkle mutations associated with autosomal dominant progressive external ophthalmoplegia lead to impaired helicase function and in vivo mtDNA replication stalling.
Squamous Intraepithelial Lesions of the Cervix
Evaluation of p16INK4a, minichromosome maintenance protein 2, DNA topoisomerase IIalpha, ProEX C, and p16INK4a/ProEX C in cervical squamous intraepithelial lesions.
Squamous Intraepithelial Lesions of the Cervix
Evaluation of p16INK4a, minichromosome maintenance protein 2, DNA topoisomerase IIalpha, ProEx C, and p16INK4a/ProEx C in cervical squamous intraepithelial lesions.
Squamous Intraepithelial Lesions of the Cervix
Validation of a novel immunocytochemical assay for topoisomerase II-alpha and minichromosome maintenance protein 2 expression in cervical cytology.
Starvation
Diverged nuclear localization of Werner helicase in human and mouse cells.
Starvation
Genome-wide array-CGH analysis reveals YRF1 gene copy number variation that modulates genetic stability in distillery yeasts.
Starvation
Mitochondrial and nuclear localization of human Pif1 helicase.
Starvation
RecQ helicases and genome stability: lessons from model organisms and human disease.
Stomach Diseases
The RecRO pathway of DNA recombinational repair in Helicobacter pylori and its role in bacterial survival in the host.
Stomach Neoplasms
Decreased FANCJ caused by 5FU contributes to the increased sensitivity to oxaliplatin in gastric cancer cells.
Stomach Neoplasms
Recurrent amplification of RTEL1 and ABCA13 and its synergistic effect associated with clinicopathological data of gastric adenocarcinoma.
Stroke
UvrD helicase unwinds DNA one base pair at a time by a two-part power stroke.
thymidine kinase deficiency
Defects in maintenance of mitochondrial DNA are associated with intramitochondrial nucleotide imbalances.
Thyroid Cancer, Papillary
MCM3 Protein Expression in Follicular and Classical Variants of Papillary Thyroid Carcinoma.
Thyroid Cancer, Papillary
Minichromosome maintenance protein 3 is a candidate proliferation marker in papillary thyroid carcinoma.
Tremor
Orthostatic Tremor, Progressive External Ophthalmoplegia, and Twinkle.
Trichothiodystrophy Syndromes
Mutations in the XPD helicase gene result in XP and TTD phenotypes, preventing interaction between XPD and the p44 subunit of TFIIH.
Trichothiodystrophy Syndromes
Premature aging in mice deficient in DNA repair and transcription.
Trichothiodystrophy Syndromes
The DNA repair helicases XPD and FancJ have essential iron-sulfur domains.
Tuberculosis
Characterization of physical interaction between replication initiator protein DnaA and replicative helicase from Mycobacterium tuberculosis H37Rv.
Tuberculosis
Enzymatic activities and DNA substrate specificity of Mycobacterium tuberculosis DNA helicase XPB.
Tuberculosis
Hexameric ring structure of the N-terminal domain of Mycobacterium tuberculosis DnaB helicase.
Tuberculosis
Mycobacterium tuberculosis UvrB is a robust DNA-stimulated ATPase that also possesses structure-specific ATP-dependent DNA helicase activity.
Tuberculosis
The adnAB locus, encoding a putative helicase-nuclease activity, is essential in Streptomyces.
Uterine Cervical Neoplasms
An interaction network driven approach for identifying biomarkers for progressing cervical intraepithelial neoplasia.
Uterine Cervical Neoplasms
Comparative analysis of cervical cancer in women and in a human papillomavirus-transgenic mouse model: identification of minichromosome maintenance protein 7 as an informative biomarker for human cervical cancer.
Uterine Cervical Neoplasms
First evidence for the contribution of the genetic variations of BRCA1-interacting protein 1 (BRIP1) to the genetic susceptibility of cervical cancer.
Uterine Cervical Neoplasms
Proteomic alterations in early stage cervical cancer.
Uterine Cervical Neoplasms
The role of MCM5 expression in cervical cancer: Correlation with progression and prognosis.
Vaccinia
Stimulation of vaccinia virion DNA helicase I8R, but not A18R, by a vaccinia core protein L4R, an ssDNA binding protein.
Vaccinia
The vaccinia virus A18R DNA helicase is a postreplicative negative transcription elongation factor.
Vaccinia
Vaccinia virion protein I8R has both DNA and RNA helicase activities: implications for vaccinia virus transcription.
Vaccinia
Vaccinia virus gene A18R DNA helicase is a transcript release factor.
Vaccinia
Vaccinia virus gene A18R encodes an essential DNA helicase.
Virus Diseases
DEAD-Box Helicase DDX25 Is a Negative Regulator of Type I Interferon Pathway and Facilitates RNA Virus Infection.
Virus Diseases
Improved detection reveals active ?-papillomavirus infection in skin lesions from kidney transplant recipients.
Virus Diseases
The origin-binding domain of the herpes simplex virus type 1 UL9 protein is not required for DNA helicase activity.
Werner Syndrome
A cascade leading to premature aging phenotypes including abnormal tumor profiles in Werner syndrome (review).
Werner Syndrome
A case of Werner syndrome without metabolic abnormality: implications for the early pathophysiology.
Werner Syndrome
A conserved and species-specific functional interaction between the Werner syndrome-like exonuclease atWEX and the Ku heterodimer in Arabidopsis.
Werner Syndrome
A deletion within the murine Werner syndrome helicase induces sensitivity to inhibitors of topoisomerase and loss of cellular proliferative capacity.
Werner Syndrome
A gene encoding an RNase D exonuclease-like protein is required for post-transcriptional silencing in Arabidopsis.
Werner Syndrome
A lack of telomeric non-reciprocal recombination (TENOR) may account for the premature proliferation blockade of Werner's syndrome fibroblasts.
Werner Syndrome
A model for the phenotypic presentation of Werner's syndrome.
Werner Syndrome
Accelerated aging syndromes, are they relevant to normal human aging?
Werner Syndrome
ACE, PAI-1, decorin and Werner helicase genes are not associated with the development of renal disease in European patients with type 1 diabetes.
Werner Syndrome
Action-at-a-Distance Mutagenesis Induced by Oxidized Guanine in Werner Syndrome Protein-Reduced Human Cells.
Werner Syndrome
Active Control of Repetitive Structural Transitions between Replication Forks and Holliday Junctions by Werner Syndrome Helicase.
Werner Syndrome
Age related expression of Werner's syndrome protein in selected tissues and coexpression of transcription factors.
Werner Syndrome
Aging stem cells. A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging.
Werner Syndrome
Analysis of the Xenopus Werner syndrome protein in DNA double-strand break repair.
Werner Syndrome
Ascorbate improves metabolic abnormalities in Wrn mutant mice but not the free radical scavenger catechin.
Werner Syndrome
ATM kinase enables the functional axis of YAP, PML and p53 to ameliorate loss of Werner protein-mediated oncogenic senescence.
Werner Syndrome
Atypical meningioma in Werner syndrome: a case report.
Werner Syndrome
Binding specificity determines polarity of DNA unwinding by the Sgs1 protein of S. cerevisiae.
Werner Syndrome
Biochemical and kinetic characterization of the DNA helicase and exonuclease activities of werner syndrome protein.
Werner Syndrome
Biochemical characterization of an exonuclease from Arabidopsis thaliana reveals similarities to the DNA exonuclease of the human Werner syndrome protein.
Werner Syndrome
Biochemical characterization of the DNA substrate specificity of Werner syndrome helicase.
Werner Syndrome
Biochemical characterization of the WRN-1 RecQ helicase of Caenorhabditis elegans.
Werner Syndrome
BLM is an early responder to DNA double-strand breaks.
Werner Syndrome
Camptothecin targets WRN protein: mechanism and relevance in clinical breast cancer.
Werner Syndrome
Catalytic activities of Werner protein are affected by adduction with 4-hydroxy-2-nonenal.
Werner Syndrome
Cellular deficiency of Werner syndrome protein or RECQ1 promotes genotoxic potential of hydroquinone and benzo[a]pyrene exposure.
Werner Syndrome
Characterization of the nuclear localization signal in the DNA helicase involved in Werner's syndrome.
Werner Syndrome
Characterization of the slow-growth phenotype of S. cerevisiae Whip/Mgs1 Sgs1 double deletion mutants.
Werner Syndrome
Characterization of Werner syndrome protein DNA helicase activity: directionality, substrate dependence and stimulation by replication protein A.
Werner Syndrome
Chromosome breakage syndromes and cancer.
Werner Syndrome
Cigarette smoke induces cellular senescence via Werner's syndrome protein down-regulation.
Werner Syndrome
Clinical outcome and mechanism of soft tissue calcification in werner syndrome.
Werner Syndrome
Cognitive deficit in hippocampal-dependent tasks in Werner syndrome mouse model.
Werner Syndrome
Comparison of proliferation and genomic instability responses to WRN silencing in hematopoietic HL60 and TK6 cells.
Werner Syndrome
Conserved helicase domain of human RecQ4 is required for strand annealing-independent DNA unwinding.
Werner Syndrome
Coordinate action of the helicase and 3' to 5' exonuclease of Werner syndrome protein.
Werner Syndrome
Depletion of Werner helicase results in mitotic hyperrecombination and pleiotropic homologous and nonhomologous recombination phenotypes.
Werner Syndrome
Detection by epitope-defined monoclonal antibodies of Werner DNA helicases in the nucleoplasm and their upregulation by cell transformation and immortalization.
Werner Syndrome
Diagnosis of Werner syndrome by immunoblot analysis.
Werner Syndrome
Distinct proteins encoded by alternative transcripts of the PURG gene, located contrapodal to WRN on chromosome 8, determined by differential termination/polyadenylation.
Werner Syndrome
Divergent cellular phenotypes of human and mouse cells lacking the Werner syndrome RecQ helicase.
Werner Syndrome
DNA damage-induced translocation of the Werner helicase is regulated by acetylation.
Werner Syndrome
DNA helicase activity in Werner's syndrome gene product synthesized in a baculovirus system.
Werner Syndrome
DNA repair deficiency in neurodegeneration.
Werner Syndrome
DNA secondary structure of the released strand stimulates WRN helicase action on forked duplexes without coordinate action of WRN exonuclease.
Werner Syndrome
DNA2-An Important Player in DNA Damage Response or Just Another DNA Maintenance Protein?
Werner Syndrome
DNase I footprinting and enhanced exonuclease function of the bipartite Werner syndrome protein (WRN) bound to partially melted duplex DNA.
Werner Syndrome
Down regulation of miR-124 in both Werner syndrome DNA helicase mutant mice and mutant Caenorhabditis elegans wrn-1 reveals the importance of this microRNA in accelerated aging.
Werner Syndrome
Down-regulation of the defective transcripts of the Werner's syndrome gene in the cells of patients.
Werner Syndrome
Elevated incidence of loss of heterozygosity (LOH) in an sgs1 mutant of Saccharomyces cerevisiae: roles of yeast RecQ helicase in suppression of aneuploidy, interchromosomal rearrangement, and the simultaneous incidence of both events during mitotic growth.
Werner Syndrome
Evidence for a replication function of FFA-1, the Xenopus orthologue of Werner syndrome protein.
Werner Syndrome
Expression differences by continent of origin point to the immortalization process.
Werner Syndrome
Failure to complement abnormal phenotypes of simian virus 40-transformed Werner syndrome cells by introduction of a normal human chromosome 8.
Werner Syndrome
Fibroblasts from Werner syndrome patients: cancer cells derived by experimental introduction of oncogenes maintain malignant properties despite entering crisis.
Werner Syndrome
Folate modulates guanine-quadruplex frequency and DNA damage in Werner syndrome.
Werner Syndrome
Functional interaction of p53 and BLM DNA helicase in apoptosis.
Werner Syndrome
Functional role of the Werner syndrome RecQ helicase in human fibroblasts.
Werner Syndrome
Genetic analysis of the Saccharomyces cerevisiae Sgs1 helicase defines an essential function for the Sgs1-Top3 complex in the absence of SRS2 or TOP1.
Werner Syndrome
Human cytomegalovirus UL97 kinase prevents the deposition of mutant protein aggregates in cellular models of Huntington's disease and Ataxia.
Werner Syndrome
Human werner syndrome DNA helicase unwinds tetrahelical structures of the fragile X syndrome repeat sequence d(CGG)n.
Werner Syndrome
Identification and characterization of a Drosophila ortholog of WRN exonuclease that is required to maintain genome integrity.
Werner Syndrome
Identification of the Xenopus DNA2 protein as a major nuclease for the 5'->3' strand-specific processing of DNA ends.
Werner Syndrome
In vivo function of the conserved non-catalytic domain of Werner syndrome helicase in DNA replication.
Werner Syndrome
Increased chemotherapeutic activity of camptothecin in cancer cells by siRNA-induced silencing of WRN helicase.
Werner Syndrome
Inhibition of helicase activity by a small molecule impairs Werner syndrome helicase (WRN) function in the cellular response to DNA damage or replication stress.
Werner Syndrome
Inhibition of unwinding of G-quadruplex structures by Sgs1 helicase in the presence of N,N'-bis[2-(1-piperidino)ethyl]-3,4,9,10-perylenetetracarboxylic diimide, a G-quadruplex-interactive ligand.
Werner Syndrome
Inhibition of Werner Syndrome Helicase Activity by Benzo[a]pyrene Diol Epoxide Adducts Can Be Overcome by Replication Protein A.
Werner Syndrome
Inhibition of Werner syndrome helicase activity by benzo[c]phenanthrene diol epoxide dA adducts in DNA is both strand-and stereoisomer-dependent.
Werner Syndrome
Interactions between the Werner syndrome helicase and DNA polymerase delta specifically facilitate copying of tetraplex and hairpin structures of the d(CGG)n trinucleotide repeat sequence.
Werner Syndrome
Interruption of the fragile X syndrome expanded sequence d(CGG)(n) by interspersed d(AGG) trinucleotides diminishes the formation and stability of d(CGG)(n) tetrahelical structures.
Werner Syndrome
Involvement of WRN helicase in immortalization and tumorigenesis by the telomeric crisis pathway (Review).
Werner Syndrome
Ku heterodimer binds to both ends of the Werner protein and functional interaction occurs at the Werner N-terminus.
Werner Syndrome
Linkage between Werner syndrome protein and the Mre11 complex via Nbs1.
Werner Syndrome
LMNA mutations in atypical Werner's syndrome.
Werner Syndrome
Loss of Bloom syndrome protein destabilizes human gene cluster architecture.
Werner Syndrome
Loss of Werner syndrome protein function promotes aberrant mitotic recombination.
Werner Syndrome
Mechanism and substrate specificity of telomeric protein POT1 stimulation of the Werner syndrome helicase.
Werner Syndrome
Mechanistic analysis of a DNA end processing pathway mediated by the Xenopus Werner syndrome protein.
Werner Syndrome
Metabolic and Phenotypic Differences between Mice Producing a Werner Syndrome Helicase Mutant Protein and Wrn Null Mice.
Werner Syndrome
Modulation of telomeres in alternative lengthening of telomeres type I like human cells by the expression of werner protein and telomerase.
Werner Syndrome
Molecular biology of Werner syndrome.
Werner Syndrome
Molecular characterization of nuclear DNA helicase II (RNA helicase A).
Werner Syndrome
Molecular cooperation between the Werner syndrome protein and replication protein A in relation to replication fork blockage.
Werner Syndrome
Mut-7 of C. elegans, required for transposon silencing and RNA interference, is a homolog of Werner syndrome helicase and RNaseD.
Werner Syndrome
Mutations induced by 8-oxo-7,8-dihydroguanine in WRN- and DNA polymerase ?-double knockdown cells.
Werner Syndrome
Nonfunctional mutant Wrn protein leads to neurological deficits, neuronal stress, microglial alteration, and immune imbalance in a mouse model of Werner syndrome.
Werner Syndrome
Nuclear DNA helicase II (RNA helicase A) interacts with Werner syndrome helicase and stimulates its exonuclease activity.
Werner Syndrome
Oligomeric ring structure of the Bloom's syndrome helicase.
Werner Syndrome
p38 (MAPK) stress signalling in replicative senescence in fibroblasts from progeroid and genomic instability syndromes.
Werner Syndrome
p53-mediated apoptosis is attenuated in Werner syndrome cells.
Werner Syndrome
Partial lipodystrophy with severe insulin resistance and adult progeria Werner syndrome.
Werner Syndrome
Perturbed replication induced genome wide or at common fragile sites is differently managed in the absence of WRN.
Werner Syndrome
Physical and functional interactions between Werner syndrome helicase and mismatch-repair initiation factors.
Werner Syndrome
Physical and Functional Interactions of Caenorhabditis elegansWRN-1 Helicase with RPA-1.
Werner Syndrome
Physical and functional mapping of the replication protein a interaction domain of the werner and bloom syndrome helicases.
Werner Syndrome
Promyelocytic leukemia protein interacts with werner syndrome helicase and regulates double-strand break repair in ?-irradiation-induced DNA damage responses.
Werner Syndrome
Quantitative analysis of Werner helicase activity using the single-molecule fluorescence detection system MF10S.
Werner Syndrome
Rapamycin decreases DNA damage accumulation and enhances cell growth of WRN-deficient human fibroblasts.
Werner Syndrome
Recombination-mediated lengthening of terminal telomeric repeats requires the Sgs1 DNA helicase.
Werner Syndrome
RECQ DNA helicases and osteosarcoma.
Werner Syndrome
RECQ helicase disease and related progeroid syndromes: RECQ2018 meeting.
Werner Syndrome
Reduction of Werner syndrome protein enhances G:C-->A:T transition by O
Werner Syndrome
Relationships between putative G-quadruplex-forming sequences, RecQ helicases, and transcription.
Werner Syndrome
Replication fork regression in vitro by the Werner syndrome protein (WRN): holliday junction formation, the effect of leading arm structure and a potential role for WRN exonuclease activity.
Werner Syndrome
Replication protein A stimulates the werner syndrome protein branch migration activity.
Werner Syndrome
Requirement of yeast SGS1 and SRS2 genes for replication and transcription.
Werner Syndrome
Residues in the RecQ C-terminal Domain of the Human Werner Syndrome Helicase Are Involved in Unwinding G-quadruplex DNA.
Werner Syndrome
Resveratrol Improves Insulin Resistance Hyperglycemia and Hepatosteatosis But Not Hypertriglyceridemia, Inflammation, and Life Span in a Mouse Model for Werner Syndrome.
Werner Syndrome
Role for the Werner syndrome protein in the promotion of tumor cell growth.
Werner Syndrome
Roles of RNase P and Its Subunits.
Werner Syndrome
Roles of the Werner syndrome RecQ helicase in DNA replication.
Werner Syndrome
Rothmund-Thomson syndrome due to RECQ4 helicase mutations: report and clinical and molecular comparisons with Bloom syndrome and Werner syndrome.
Werner Syndrome
Rothmund-thomson syndrome responsible gene, RECQL4: genomic structure and products.
Werner Syndrome
Serines 440 and 467 in the Werner syndrome protein are phosphorylated by DNA-PK and affects its dynamics in response to DNA double strand breaks.
Werner Syndrome
Serum vitamin C levels modulate the lifespan and endoplasmic reticulum stress response pathways in mice synthesizing a nonfunctional mutant WRN protein.
Werner Syndrome
Severe toxicity following induction chemotherapy for acute myelogenous leukemia in a patient with Werner's syndrome.
Werner Syndrome
Single-molecule studies reveal reciprocating of WRN helicase core along ssDNA during DNA unwinding.
Werner Syndrome
Solution structure of the RecQ C-terminal domain of human Bloom syndrome protein.
Werner Syndrome
Stimulation of flap endonuclease-1 by the Bloom's syndrome protein.
Werner Syndrome
Strand exchange of telomeric DNA catalyzed by the Werner syndrome protein (WRN) is specifically stimulated by TRF2.
Werner Syndrome
Structural mechanisms of human RecQ helicases WRN and BLM.
Werner Syndrome
Structure of the RecQ C-terminal domain of human Bloom syndrome protein.
Werner Syndrome
Studying Werner syndrome to elucidate mechanisms and therapeutics of human aging and age-related diseases.
Werner Syndrome
Targeted inhibition of WRN helicase by external guide sequence and RNase P RNA.
Werner Syndrome
Targeting an Achilles' heel of cancer with a WRN helicase inhibitor.
Werner Syndrome
Telomere dysfunction as a cause of genomic instability in Werner syndrome.
Werner Syndrome
Telomere repeat DNA forms a large non-covalent complex with unique cohesive properties which is dissociated by Werner syndrome DNA helicase in the presence of replication protein A.
Werner Syndrome
Telomere ResQue and preservation--roles for the Werner syndrome protein and other RecQ helicases.
Werner Syndrome
Telomeric protein TRF2 protects Holliday junctions with telomeric arms from displacement by the Werner syndrome helicase.
Werner Syndrome
The Caenorhabditis elegans Werner syndrome protein functions upstream of ATR and ATM in response to DNA replication inhibition and double-strand DNA breaks.
Werner Syndrome
The DNA repair endonuclease XPG interacts directly and functionally with the WRN helicase defective in Werner syndrome.
Werner Syndrome
The DNA structure and sequence preferences of WRN underlie its function in telomeric recombination events.
Werner Syndrome
The effect of 2-deoxy-D-glucose on Werner syndrome RecQ helicase gene.
Werner Syndrome
The effect of resveratrol on the werner syndrome RecQ helicase gene and telomerase activity.
Werner Syndrome
The human WRN and BLM RecQ helicases differentially regulate cell proliferation and survival after chemotherapeutic DNA damage.
Werner Syndrome
The N-terminal domain of the large subunit of human replication protein A binds to Werner syndrome protein and stimulates helicase activity.
Werner Syndrome
The ophthalmic diagnosis and management of four siblings with Werner syndrome.
Werner Syndrome
The role of WRNIP1 in genome maintenance.
Werner Syndrome
The Saccharomyces cerevisiae WRN homolog Sgs1p participates in telomere maintenance in cells lacking telomerase.
Werner Syndrome
The Werner Protein Acts as a Coactivator of Nuclear Factor ?B (NF-?B) on HIV-1 and Interleukin-8 (IL-8) Promoters.
Werner Syndrome
The Werner syndrome exonuclease facilitates DNA degradation and high fidelity DNA polymerization by human DNA polymerase ?
Werner Syndrome
The Werner syndrome helicase and exonuclease cooperate to resolve telomeric D loops in a manner regulated by TRF1 and TRF2.
Werner Syndrome
The Werner Syndrome Helicase Coordinates Sequential Strand Displacement and FEN1-Mediated Flap Cleavage during Polymerase ? Elongation.
Werner Syndrome
The Werner syndrome helicase is a cofactor for HIV-1 long terminal repeat transactivation and retroviral replication.
Werner Syndrome
The Werner syndrome helicase protein is required for cell proliferation, immortalization, and tumorigenesis in Scaffold Attachment Factor B1 deficient mice.
Werner Syndrome
The Werner syndrome helicase/exonuclease (WRN) disrupts and degrades D-loops in vitro.
Werner Syndrome
The Werner syndrome protein binds replication fork and holliday junction DNAs as an oligomer.
Werner Syndrome
The Werner syndrome protein contributes to induction of p53 by DNA damage.
Werner Syndrome
The Werner syndrome protein is a DNA helicase.
Werner Syndrome
The Werner syndrome protein is distinguished from the Bloom syndrome protein by its capacity to tightly bind diverse DNA structures.
Werner Syndrome
The Werner syndrome protein limits the error-prone 8-oxo-dG lesion bypass activity of human DNA polymerase kappa.
Werner Syndrome
The Werner syndrome RECQ helicase targets G4 DNA in human cells to modulate transcription.
Werner Syndrome
Tumorigenic effect of nonfunctional p53 or p21 in mice mutant in the Werner syndrome helicase.
Werner Syndrome
Vitamin C alters the amount of specific endoplasmic reticulum associated proteins involved in lipid metabolism in the liver of mice synthesizing a nonfunctional Werner syndrome (Wrn) mutant protein.
Werner Syndrome
Vitamin C restores healthy aging in a mouse model for Werner syndrome.
Werner Syndrome
Werner complex deficiency in cells disrupts the Nuclear Pore Complex and the distribution of lamin B1.
Werner Syndrome
Werner protein protects nonproliferating cells from oxidative DNA damage.
Werner Syndrome
Werner syndrome (WRN) DNA helicase and base excision repair (BER) factors maintain endothelial homeostasis.
Werner Syndrome
Werner syndrome gene variants in human sarcomas.
Werner Syndrome
Werner syndrome helicase (WRN), nuclear DNA helicase II (NDH II) and histone gammaH2AX are localized to the centrosome.
Werner Syndrome
Werner syndrome helicase activity is essential in maintaining fragile site stability.
Werner Syndrome
Werner syndrome helicase contains a 5'-->3' exonuclease activity that digests DNA and RNA strands in DNA/DNA and RNA/DNA duplexes dependent on unwinding.
Werner Syndrome
Werner syndrome helicase has a critical role in DNA damage responses in the absence of a functional fanconi anemia pathway.
Werner Syndrome
Werner syndrome protein associates with gamma H2AX in a manner that depends upon Nbs1.
Werner Syndrome
Werner syndrome protein directly binds to the AAA ATPase p97/VCP in an ATP-dependent fashion.
Werner Syndrome
Werner syndrome protein limits MYC-induced cellular senescence.
Werner Syndrome
Werner syndrome protein participates in a complex with RAD51, RAD54, RAD54B and ATR in response to ICL-induced replication arrest.
Werner Syndrome
Werner syndrome protein prevents DNA breaks upon chromatin structure alteration.
Werner Syndrome
Werner syndrome protein suppresses the formation of large deletions during the replication of human telomeric sequences.
Werner Syndrome
Werner syndrome protein. I. DNA helicase and dna exonuclease reside on the same polypeptide.
Werner Syndrome
Werner syndrome protein. II. Characterization of the integral 3' --> 5' DNA exonuclease.
Werner Syndrome
Werner's syndrome as a hereditary risk factor for exocrine pancreatic cancer: Potential role of WRN in pancreatic tumorigenesis and patient-tailored therapy.
Werner Syndrome
What can we learn from Werner syndrome? A biased view from a rheumatologist.
Werner Syndrome
WRN functions in a RAD18-dependent damage avoidance pathway.
Werner Syndrome
WRN helicase defective in the premature aging disorder Werner syndrome genetically interacts with topoisomerase 3 and restores the top3 slow growth phenotype of sgs1 top3.
Werner Syndrome
WRN helicase expression in Werner syndrome cell lines.
Werner Syndrome
WRN or telomerase constructs reverse 4-nitroquinoline 1-oxide sensitivity in transformed Werner syndrome fibroblasts.
Werner Syndrome
WRN polymorphisms affect expression levels of plasminogen activator inhibitor type 1 in cultured fibroblasts.
Werner Syndrome
WRN protein and Werner syndrome.
Werner Syndrome
WRN protein as a novel erythroblast immunohistochemical marker with applications for the diagnosis of Werner syndrome.
Werner Syndrome
WRN regulates pathway choice between classical and alternative non-homologous end joining.
Werner Syndrome
[Biological functions of DNA helicase responsible for Werner syndrome]
Werner Syndrome
[Werner's syndrome and endocrine disorders]
Xeroderma Pigmentosum
A presumed DNA helicase encoded by ERCC-3 is involved in the human repair disorders xeroderma pigmentosum and Cockayne's syndrome.
Xeroderma Pigmentosum
Cloning of a cDNA from Arabidopsis thaliana homologous to the human XPB gene.
Xeroderma Pigmentosum
Conformational effects of a common codon 751 polymorphism on the C-terminal domain of the xeroderma pigmentosum D protein.
Xeroderma Pigmentosum
Differential developmental expression of the rep B and rep D xeroderma pigmentosum related DNA helicase genes from Dictyostelium discoideum.
Xeroderma Pigmentosum
Disruption of the mouse xeroderma pigmentosum group D DNA repair/basal transcription gene results in preimplantation lethality.
Xeroderma Pigmentosum
Effect of polymorphisms in XPD on clinical outcomes of platinum-based chemotherapy for Chinese non-small cell lung cancer patients.
Xeroderma Pigmentosum
ERCC2 /XPD gene polymorphisms and lung cancer: a HuGE review.
Xeroderma Pigmentosum
Genetic variation in XPD predicts treatment outcome and risk of acute myeloid leukemia following chemotherapy.
Xeroderma Pigmentosum
Homozygous Wildtype of XPD K751Q Polymorphism Is Associated with Increased Risk of Nasopharyngeal Carcinoma in Malaysian Population.
Xeroderma Pigmentosum
Human JC virus small tumour antigen inhibits nucleotide excision repair and sensitises cells to DNA-damaging agents.
Xeroderma Pigmentosum
Human xeroderma pigmentosum group D gene encodes a DNA helicase.
Xeroderma Pigmentosum
Mutational analysis of ERCC3, which is involved in DNA repair and transcription initiation: identification of domains essential for the DNA repair function.
Xeroderma Pigmentosum
Mutations in the XPD helicase gene result in XP and TTD phenotypes, preventing interaction between XPD and the p44 subunit of TFIIH.
Xeroderma Pigmentosum
Nucleotide excision repair is a potential therapeutic target in multiple myeloma.
Xeroderma Pigmentosum
Phenotypic heterogeneity in the XPB DNA helicase gene (ERCC3): xeroderma pigmentosum without and with Cockayne syndrome.
Xeroderma Pigmentosum
Telomere attrition and genomic instability in xeroderma pigmentosum type-B deficient fibroblasts under oxidative stress.
Xeroderma Pigmentosum
The Association of the Xeroderma Pigmentosum Group D DNA Helicase (XPD) with Transcription Factor IIH Is Regulated by the Cytosolic Iron-Sulfur Cluster Assembly Pathway.
Xeroderma Pigmentosum
The DNA helicases acting in nucleotide excision repair, XPD, CSB and XPB, are not required for PCNA-dependent repair of abasic sites.
Xeroderma Pigmentosum
The xeroderma pigmentosum group B protein ERCC3 produced in the baculovirus system exhibits DNA helicase activity.
Xeroderma Pigmentosum
Two individuals with features of both xeroderma pigmentosum and trichothiodystrophy highlight the complexity of the clinical outcomes of mutations in the XPD gene.
Xeroderma Pigmentosum
Warsaw breakage syndrome, a cohesinopathy associated with mutations in the XPD helicase family member DDX11/ChlR1.
Yellow Fever
Towards the design of flavivirus helicase/NTPase inhibitors: crystallographic and mutagenesis studies of the dengue virus NS3 helicase catalytic domain.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
HOME
login
history
all enzymes
BRENDA home
History
3.6.4.12 DNA helicase
more
top
