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Disease on EC 3.6.4.10 - non-chaperonin molecular chaperone ATPase

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DISEASE
TITLE OF PUBLICATION
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Aberrant Crypt Foci
Modulation of intestinal environment by prebiotic germinated barley foodstuff prevents chemo-induced colonic carcinogenesis in rats.
Abortion, Habitual
Expression pattern of PRM2, HSP90 and WNT5A in male partners of couples experiencing idiopathic recurrent miscarriages.
Recurrent miscarriages, innate immunity, and autoimmune reaction to chlamydial 60-kDa heat shock protein-is there an association?
Abortion, Missed
Potential role of heat-shock protein 70 and interleukin-15 in the pathogenesis of threatened spontaneous abortions.
Serum interleukin-1?, interleukin-8 and anti-heat shock 60 Chlamydia trachomatis antibodies as markers of ectopic pregnancy.
Abortion, Spontaneous
A comparison in concentration of heat shock proteins (HSP) 70 and 90 on chorionic villi of human placenta in normal pregnancies and in missed miscarriages.
Cell-mediated immunity to human and Escherichia coli 60-kDa heat shock protein in women: association with a history of spontaneous abortion and endometriosis.
Circulating antibodies to a conserved epitope of the Chlamydia trachomatis 60 kDa heat shock protein (hsp60) in infertile couples and its relationship to antibodies to C.trachomatis surface antigens and the Escherichia coli and human HSP60.
Early changes of the heat-shock protein 60 to 70 ratio as prediction of miscarriage in pregnancy.
Immune Recognition of the 60kD Heat Shock Protein: Implications for Subsequent Fertility.
Potential role of heat-shock protein 70 and interleukin-15 in the pathogenesis of threatened spontaneous abortions.
The contribution of placental oxidative stress to early pregnancy failure.
The study of the relationship between aberrant expression of hot shock protein 70 (HSP70) and spontaneous abortion.
Trophoblastic oxidative stress in relation to temporal and regional differences in maternal placental blood flow in normal and abnormal early pregnancies.
Abscess
Heat-shock protein HSP70-2 genotypes in patients with Crohn's disease: a more severe clinical course with intestinal complications in presence of the PstI-polymorphism.
Serum biomarkers of Burkholderia mallei infection elucidated by proteomic imaging of skin and lung abscesses.
Acidosis
Acidosis acts through HSP90 in a PHD/VHL-independent manner to promote HIF function and stem cell maintenance in glioma.
Astrocyte survival and HSP70 heat shock protein induction following heat shock and acidosis.
Bicarbonate correction of ketoacidosis alters host-pathogen interactions and alleviates mucormycosis.
Cytoprotective effects of acidosis via heat shock protein HSP27 against the anticancer drug doxorubicin.
Expression and release of glucose-regulated protein-78 (GRP78) in multiple myeloma.
Heat-shock proteins expression in fish central nervous system and its possible relation with water acidosis resistance.
Spontaneous and controllable activation of suicide gene expression driven by the stress-inducible grp78 promoter resulting in eradication of sizable human tumors.
Vascular targeting and antiangiogenesis agents induce drug resistance effector GRP78 within the tumor microenvironment.
Acidosis, Lactic
Bicarbonate correction of ketoacidosis alters host-pathogen interactions and alleviates mucormycosis.
Glucose regulated protein 78: A critical link between tumor microenvironment and cancer hallmarks.
Identification of the Transmembrane Glucose Regulated Protein 78 as a Biomarker for the Brain Cancer Glioblastoma Multiforme by Gene Expression and Proteomic Studies.
Acne Vulgaris
Heat shock proteins and inflammatory acne vulgaris: molecular cloning, overexpression and purification of a propionibacterium acnes GroEL and DnaK homologue.
Proinflammatory cytokine production by human keratinocytes stimulated with Propionibacterium acnes and P. acnes GroEL.
Acquired Immunodeficiency Syndrome
(-)- Epigallocatechin-3-gallate induces GRP78 accumulation in the ER and shifts mesothelioma constitutive UPR into proapoptotic ER stress.
Anti-GRP78 autoantibodies induce endothelial cell activation and accelerate the development of atherosclerotic lesions.
Assembly of heterodimeric luciferase after de novo synthesis of subunits in rabbit reticulocyte lysate involves hsc70 and hsp40 at a post-translational stage.
ATP-Driven Nonequilibrium Activation of Kinase Clients by the Molecular Chaperone Hsp90.
Comparative analysis of differential gene expression of HSP40 and HSP70 family isoforms during heat stress and HIV-1 infection in T-cells.
Endocytic Trafficking of DMP1 and GRP78 Complex Facilitates Osteogenic Differentiation of Human Periodontal Ligament Stem Cells.
Hsp90 Maintains Proteostasis of the Galactose Utilization Pathway To Prevent Cell Lethality.
Identification of Genes Whose Expression Profile Is Associated with Non-Progression towards AIDS Using eQTLs.
Interaction mechanism of Mycobacterium tuberculosis GroEL2 protein with macrophage Lectin-like, oxidized low-density lipoprotein receptor-1: An integrated computational and experimental study.
Interaction of vanadate oligomers and permolybdate with the 90-kDa heat-shock protein, Hsp90.
Modulation of heat shock protein 90 affects TGF-?-induced collagen synthesis in human dermal fibroblast cells.
Phenotypic diversity and altered environmental plasticity in Arabidopsis thaliana with reduced Hsp90 levels.
Pre-exercise alkalosis attenuates the heat shock protein 72 response to a single-bout of anaerobic exercise.
Protein structural transitions and their functional role.
The co-chaperone Cdc37 regulates the rabies virus phosphoprotein stability by targeting to Hsp90AA1 machinery.
The G?-interacting vesicle-associated protein interacts with and promotes cell surface localization of GRP78 during endoplasmic reticulum stress.
The Small Heat Shock Protein p26 Aids Development of Encysting Artemia Embryos, Prevents Spontaneous Diapause Termination and Protects against Stress.
To fold or not to fold: modulation and consequences of Hsp90 inhibition.
ACTH-Secreting Pituitary Adenoma
A C-terminal HSP90 inhibitor restores glucocorticoid sensitivity and relieves a mouse allograft model of Cushing disease.
Advances in the medical treatment of Cushing's syndrome.
Recent advances in understanding corticotroph pituitary tumor initiation and progression.
Acute Coronary Syndrome
Antibody titres to heat shock protein 27 are elevated in patients with acute coronary syndrome.
Association of plasma concentration of small heat shock protein b7 with acute coronary syndrome.
Changes in Plasma Level of Heat Shock Protein 27 After Acute Coronary Syndrome.
Expression of heat shock protein 27 in human atherosclerotic plaques and increased plasma level of heat shock protein 27 in patients with acute coronary syndrome.
Inverse association of ApoB and HSP60 antibodies with coronary artery disease in Indian population.
Acute Kidney Injury
Activation of AMP-activated protein kinase inhibits ER stress and renal fibrosis.
Acute Kidney Injury, an Id Reaction and HSP90.
Association between heat shock protein 72 gene polymorphism and acute renal failure in premature neonates.
Association of HSP73 with the acquired resistance to uranyl acetate-induced acute renal failure.
Down-regulation of GRP78 alleviates lipopolysaccharide-induced acute kidney injury.
Genome-wide association study of myocardial infarction, atrial fibrillation, acute stroke, acute kidney injury and delirium after cardiac surgery - a sub-analysis of the RIPHeart-Study.
Glutamine attenuates tubular cell apoptosis in acute kidney injury via inhibition of the c-Jun N-terminal kinase phosphorylation of 14-3-3*
Heat Shock Protein 27 Is an Emerging Predictor of Contrast-Induced Acute Kidney Injury on Patients Subjected to Percutaneous Coronary Interventions.
Heat shock protein 72 (Hsp72) specific induction and temporal stability in urine samples as a reliable biomarker of acute kidney injury (AKI).
Hsp72 is a novel biomarker to predict acute kidney injury in critically ill patients.
Hsp72 is an early and sensitive biomarker to detect acute kidney injury.
Hsp90 Relieves Heat Stress-Induced Damage in Mouse Kidneys: Involvement of Antiapoptotic PKM2-AKT and Autophagic HIF-1? Signaling.
Human heat shock protein 27-overexpressing mice are protected against acute kidney injury after hepatic ischemia and reperfusion.
Induction and altered localization of 90-kDa heat-shock protein in rat kidneys with cisplatin-induced acute renal failure.
Mediators and mechanisms of heat shock protein 70 based cytoprotection in obstructive nephropathy.
NLRP3 expression and urinary HSP72 in relation to biomarkers of inflammation and oxidative stress in diabetic nephropathy patients.
Perioperative urinary heat shock protein 72 as an early marker of acute kidney injury in dogs.
Small Heat Shock Protein Beta-1 (HSPB1) Is Upregulated and Regulates Autophagy and Apoptosis of Renal Tubular Cells in Acute Kidney Injury.
Tubular Urinary Biomarkers Do Not Identify Etiology of Acute Kidney Injury in Kidney Transplant Recipients.
Urinary heat shock protein 72 as a biomarker of acute kidney injury in dogs.
Urinary neutrophil gelatinase-associated lipocalin predicts graft loss after acute kidney injury in kidney transplant.
Acute Lung Injury
Activation of the stress protein response inhibits the STAT1 signalling pathway and iNOS function in alveolar macrophages: role of Hsp90 and Hsp70.
Extracellular heat shock protein 72 is a marker of the stress protein response in acute lung injury.
Heat Shock Protein A12B Protects Vascular Endothelial Cells Against Sepsis-Induced Acute Lung Injury in Mice.
Heat shock response and acute lung injury.
Histone deacetylase inhibitors prevent pulmonary endothelial hyperpermeability and acute lung injury by regulating heat shock protein 90 function.
Hypobaric hypoxia preconditioning attenuates acute lung injury during high-altitude exposure in rats via up-regulating heat-shock protein 70.
Isthmin is a novel vascular permeability inducer that functions through cell-surface GRP78-mediated Src activation.
Overexpression of heat shock protein 70 enhanced mesenchymal stem cell treatment efficacy in phosgene-induced acute lung injury.
Serum levels of Hsp60 correlate with the development of acute lung injury after trauma.
Somatostatin Reduces the Acute Lung Injury of Mice via Increasing the Affinity of Glucocorticoid Receptor.
The 150-kilodalton oxygen-regulated protein ameliorates lipopolysaccharide-induced acute lung injury in mice.
The HSP90 Inhibitor, AUY-922, Protects and Repairs Human Lung Microvascular Endothelial Cells from Hydrochloric Acid-Induced Endothelial Barrier Dysfunction.
[Association of glucocoid receptor binding activity and heat shock protein expressions after acute lung injury in mice]
[Effects of over-expressing heat shock protein 60 on marrow mesenchymal stem cells in the treatment of phosgene-induced acute lung injury].
Addison Disease
Sequence homologies between hsp60 and autoantigens.
Adenocarcinoma
18?-Glycyrrhetinic acid potentiates Hsp90 inhibition-induced apoptosis in human epithelial ovarian carcinoma cells via activation of death receptor and mitochondrial pathway.
A chemical genomics-aggrephagy integrated method studying functional analysis of autophagy inducers.
A phase I pilot study of autologous heat shock protein vaccine HSPPC-96 in patients with resected pancreatic adenocarcinoma.
Association between HSP90 and Her2 in gastric and gastroesophageal carcinomas.
Chaperonin (HSP60) and annexin-2 are candidate biomarkers for non-small cell lung carcinoma.
Clinical significance of heat shock proteins in gastric cancer following hyperthermia stress: Indications for hyperthermic intraperitoneal chemoperfusion therapy.
CLPTM1L/CRR9 ectodomain interaction with GRP78 at the cell surface signals for survival and chemoresistance upon ER stress in pancreatic adenocarcinoma cells.
Comparative analysis of Hsp10 and Hsp90 expression in healthy mucosa and adenocarcinoma of the large bowel.
Comparison of the desmoplastic reaction and invading ability in invasive ductal carcinoma of the breast and prostatic adenocarcinoma based on the expression of heat shock protein 47 and fascin.
Correlation between clinicopathology and expression of heat shock protein 70 and glucose-regulated protein 94 in human colonic adenocarcinoma.
Correlation between clinicopathology and expression of heat shock protein 72 and glycoprotein 96 in human gastric adenocarcinoma.
Cytoplasmic sequestration of the tumor suppressor p53 by a heat shock protein 70 family member, mortalin, in human colorectal adenocarcinoma cell lines.
Cytoprotective mitochondrial chaperone TRAP-1 as a novel molecular target in localized and metastatic prostate cancer.
Different expression of CD44, ICAM-1, and HSP60 on primary tumor and metastases of a human pancreatic carcinoma growing in scid mice.
Effectiveness of HSV-tk suicide gene therapy driven by the Grp78 stress-inducible promoter in esophagogastric junction and gastric adenocarcinomas.
Effects of geldanamycin and other naturally occurring small molecule antagonists of heat shock protein 90 on HER2 protein expression.
Elevated GRP78 expression is associated with poor prognosis in patients with pancreatic cancer.
Eradication of murine mammary adenocarcinoma through HSVtk expression directed by the glucose-starvation inducible grp78 promoter.
Estrogen receptor gene expression and its relation to the estrogen-inducible HSP27 heat shock protein in hormone refractory prostate cancer.
Evidence for downregulation of calcium signaling proteins in advanced mouse adenocarcinoma.
Evidence of prognostic relevant expression profiles of heat-shock proteins and glucose-regulated proteins in oesophageal adenocarcinomas.
Expression and clinical significance of glucose regulated proteins GRP78 (BiP) and GRP94 (GP96) in human adenocarcinomas of the esophagus.
Expression and localization of GRP75 in human epithelial tumors and normal tissues.
Expression of ER stress and autophagy-related molecules in human non-small cell lung cancer and premalignant lesions.
Expression Of GRP78, Master Regulator Of The Unfolded Protein Response, Increases Chemoresistance In Pancreatic Ductal Adenocarcinoma.
Expressions of ATF6, XBP1, and GRP78 in normal tissue, atypical adenomatous hyperplasia, and adenocarcinoma of the lung.
Forced expression of heat-shock protein 70 increases the secretion of Hsp70 and provides protection against tumour growth.
Gene expression profiling identifies markers of ampullary adenocarcinoma.
Glucose-regulated protein 78 (GRP78) regulates colon cancer metastasis through EMT biomarkers and the NRF-2/HO-1 pathway.
GRP78 expression and prognostic significance in patients with pancreatic ductal adenocarcinoma treated with neoadjuvant therapy versus surgery first.
Heat shock protein 105 is overexpressed in a variety of human tumors.
Heat shock protein 27 as a prognostic and predictive biomarker in pancreatic ductal adenocarcinoma.
Heat shock protein 27 is over-expressed in tumor tissues and increased in sera of patients with gastric adenocarcinoma.
Heat shock protein 70 (HSP70) after laser thermotherapy of an adenocarcinoma transplanted into rat liver.
Heat shock protein 70 increases tumorigenicity and inhibits apoptosis in pancreatic adenocarcinoma.
Heat shock protein 70-2 (HSP70-2) a novel cancer testis antigen that promotes growth of ovarian cancer.
Heat shock protein 72 associated with CD44v6 in human colonic adenocarcinoma.
Heat shock protein 72/73 in relation to cytoplasmic p53 expression and prognosis in colorectal adenocarcinomas.
Heat Shock Protein 90 (HSP90) and Her2 in Adenocarcinomas of the Esophagus.
Heat Shock Protein 90 Inhibitor Effects on Pancreatic Cancer Cell Cultures.
Heat shock protein beta 3 (HSPB3) is an unfavorable molecular biomarker in colorectal adenocarcinoma.
Heat shock protein expression independently predicts clinical outcome in prostate cancer.
Heat shock protein HSP90 and its association with the cytoskeleton: a morphological study.
HSP 70 induction and thermotolerance following interstitial hyperthermia in the dunning R3327 tumor in vivo.
Hsp-27 has no diagnostic or prognostic significance in prostate or bladder cancers.
Hsp27 Protects Adenocarcinoma Cells from UV-Induced Apoptosis by Akt and p21-Dependent Pathways of Survival.
Hsp60 and Hsp10 down-regulation predicts bronchial epithelial carcinogenesis in smokers with chronic obstructive pulmonary disease.
Hsp90 inhibitor geldanamycin increases the sensitivity of resistant ovarian adenocarcinoma cell line A2780cis to cisplatin.
HSP90 inhibitors in the context of heat shock and the unfolded protein response: effects on a primary canine pulmonary adenocarcinoma cell line.
Hsp90 is expressed and represents a therapeutic target in human oesophageal cancer using the inhibitor 17-allylamino-17-demethoxygeldanamycin.
Immunohistochemical detection of pS2 protein and heat shock protein-70 in pancreatic adenocarcinomas. Relationship with disease extent and patient survival.
Immunohistochemical evaluation of PCNA, p53, HSP60, HSP10 and MUC-2 presence and expression in prostate carcinogenesis.
Immunohistochemical validation of a novel epithelial and a novel stromal marker of pancreatic ductal adenocarcinoma identified by global expression microarrays: sea urchin fascin homolog and heat shock protein 47.
Immunolocalisation of heat shock protein 72 and glycoprotein 96 in colonic adenocarcinoma.
Induced oxidative stress and decreased expression of inducible heat shock protein 70 (ihsp 70) in patients with colorectal adenocarcinomas.
Influence of HSP27 and steroid receptor status on provera sensitivity, DNA-ploidy and survival of females with endometrial cancer.
Inhibition of heat shock protein (Hsp) 90 potentiates the antiproliferative and pro-apoptotic effects of 2-(4'fluoro-phenylamino)-4H-1,3-thiazine[6,5-b]indole in A2780cis cells.
Irreversible UV inactivation of Cryptosporidium spp. despite the presence of UV repair genes.
l-Arginine supplementation prevents intestinal epithelial barrier breakdown under heat stress conditions by promoting nitric oxide synthesis.
Mortalin expression in pancreatic cancer and its clinical and prognostic significance.
Mortalin is over-expressed by colorectal adenocarcinomas and correlates with poor survival.
Mortalin/HSPA9 targeting selectively induces KRAS tumor cell death by perturbing mitochondrial membrane permeability.
Novel colorectal adenocarcinoma-associated 40- and 47-kDa protein antigens recognized by anti-60-kDa heat shock protein antibody.
Oncogenic HSP60 regulates mitochondrial oxidative phosphorylation to support Erk1/2 activation during pancreatic cancer cell growth.
Overexpression of endoplasmic reticulum stress-related proteins, XBP1s and GRP78, predicts poor prognosis in pulmonary adenocarcinoma.
Oxidative inhibition of Hsp90 disrupts the super-chaperone complex and attenuates pancreatic adenocarcinoma in vitro and in vivo.
P53 and heat shock protein 70 expressions in colorectal adenocarcinoma.
Phenethyl isothiocyanate, by virtue of its antioxidant activity, inhibits invasiveness and metastatic potential of breast cancer cells: HIF-1? as a putative target.
Preclinical Study of AUY922, a Novel Hsp90 Inhibitor, in the Treatment of Esophageal Adenocarcinoma.
Prognostic significance of heat shock protein 70 expression in early gastric carcinoma.
Pten null prostate tumorigenesis and AKT activation are blocked by targeted knockout of ER chaperone GRP78/BiP in prostate epithelium.
Quantitative patterns of Hsps in tubular adenoma compared with normal and tumor tissues reveal the value of Hsp10 and Hsp60 in early diagnosis of large bowel cancer.
Role of GRP78 inhibiting artesunate-induced ferroptosis in KRAS mutant pancreatic cancer cells.
Role of increased basal expression of heat shock protein 72 in colonic epithelial c2BBE adenocarcinoma cells.
Significance of unphosphorylated and phosphorylated heat shock protein 27 as a prognostic biomarker in pancreatic ductal adenocarcinoma.
The novel HSP90 inhibitor AT13387 potentiates radiation effects in squamous cell carcinoma and adenocarcinoma cells.
The Prognostic Impact of Heat Shock Proteins Expression in Patients with Esophageal Cancer: A Meta-Analysis.
TP53 status regulates ACSL5-induced expression of mitochondrial mortalin in enterocytes and colorectal adenocarcinomas.
Truncated O-glycans promote epithelial-to-mesenchymal transition and stemness properties of pancreatic cancer cells.
Tumor prevention and antitumor immunity with heat shock protein 70 induced by 15-deoxy-delta12,14-prostaglandin J2 in transgenic adenocarcinoma of mouse prostate cells.
Up-regulation of heat shock protein 70 in adenocarcinomas of the lung in smokers.
Upregulation of Glucose-Regulated Protein 78 in Metastatic Cancer Cells Is Necessary for Lung Metastasis Progression.
Adenocarcinoma in Situ
Expressions of ATF6, XBP1, and GRP78 in normal tissue, atypical adenomatous hyperplasia, and adenocarcinoma of the lung.
Adenocarcinoma of Lung
??? kinase ? is required for development and progression of KRAS-mutant lung adenocarcinoma.
A large animal model to evaluate the effects of Hsp90 inhibitors for the treatment of lung adenocarcinoma.
Antitumor agents 295. E-ring hydroxylated antofine and cryptopleurine analogues as antiproliferative agents: design, synthesis, and mechanistic studies.
Correction: EGFR Exon 20 Insertion Mutations Display Sensitivity to Hsp90 Inhibition in Preclinical Models and Lung Adenocarcinomas.
Docosahexaenoic Acid-mediated Inhibition of Heat Shock Protein 90-p23 Chaperone Complex and Downstream Client Proteins in Lung and Breast Cancer.
EGFR Exon 20 Insertion Mutations Display Sensitivity to Hsp90 Inhibition in Preclinical Models and Lung Adenocarcinomas.
GALNT6 promotes invasion and metastasis of human lung adenocarcinoma cells through O-glycosylating chaperone protein GRP78.
Ganetespib AIDS lung cancer survival.
Glucose-Regulated Protein 78 Signaling Regulates Hypoxia-Induced Epithelial-Mesenchymal Transition in A549 Cells.
Heat shock protein 90-? over-expression is associated with poor survival in stage I lung adenocarcinoma patients.
Heat shock protein B8 promotes proliferation and migration in lung adenocarcinoma A549 cells by maintaining mitochondrial function.
Heat shock protein-60 expression was significantly correlated with the prognosis of lung adenocarcinoma.
Hsp90 inhibition suppresses mutant EGFR-T790M signaling and overcomes kinase inhibitor resistance.
Human Genetic Relevance and Potent Antitumor Activity of Heat Shock Protein 90 Inhibition in Canine Lung Adenocarcinoma Cell Lines.
Identification of Predictive Biomarkers of Response to HSP90 Inhibitors in Lung Adenocarcinoma.
Impact of Heat Shock Protein 90 Inhibition on the Proteomic Profile of Lung Adenocarcinoma as Measured by Two-Dimensional Electrophoresis Coupled with Mass Spectrometry.
Inhibition of ALK, PI3K/MEK and HSP90 in Murine Lung Adenocarcinoma Induced by EML4-ALK Fusion Oncogene.
Inhibition of heat shock protein 90 destabilizes receptor tyrosine kinase ROR1 in lung adenocarcinoma.
Opposite Regulation of CHOP and GRP78 and Synergistic Apoptosis Induction by Selenium Yeast and Fish Oil via AMPK Activation in Lung Adenocarcinoma Cells.
Predicting drug susceptibility of non-small cell lung cancers based on genetic lesions.
Prognostic significance of heat shock protein 105 in lung adenocarcinoma.
Prognostic value of Mortalin correlates with roles in epithelial-mesenchymal transition and angiogenesis in lung adenocarcinoma.
Promising Targets and Current Clinical Trials in Metastatic Non-Squamous NSCLC.
Radioresistant human lung adenocarcinoma cells that survived multiple fractions of ionizing radiation are sensitive to HSP90 inhibition.
The antitumor agent PBT-1 directly targets HSP90 and hnRNP A2/B1 and inhibits lung adenocarcinoma growth and metastasis.
The expression and clinical significance of CLIC1 and HSP27 in lung adenocarcinoma.
The HSP90 Inhibitor Ganetespib Radiosensitizes Human Lung Adenocarcinoma Cells.
Ubiquitination of heat shock protein 27 is mediated by its interaction with Smad ubiquitination regulatory factor 2 in A549 cells.
[Different proteome of human lung adenocarcinoma cells treated with NS-398 and cisplation.]
[Down-regulation of GRP78 Enhances Chemotherapy Sensitivity to VP-16 in Lung Adenocarcinoma.]
[Expression profile of heat shock proteins in tissues and cells of lung adenocarcinoma]
[RNA Interference targeting GRP75 decreases cisplatin resistance in human lung adenocarcinoma cell].
Adenocarcinoma, Follicular
Mortalin (GRP75/HSPA9) Promotes Survival and Proliferation of Thyroid Carcinoma Cells.
Adenocarcinoma, Mucinous
BAG-1/SODD, HSP70 and HSP90 are potential prognostic markers of poor survival in node-negative breast carcinoma.
Clinicopathological and genetic characteristics of mucinous carcinomas in the colorectum.
Expression of heat shock protein 90 beta in human gastric cancer tissue and SGC7901/VCR of MDR-type gastric cancer cell line.
Adenocarcinoma, Scirrhous
Immunohistochemical distribution of heat shock protein 47 (HSP47) in scirrhous carcinoma of the stomach.
Adenoma
60KDa chaperonin (HSP60) is over-expressed during colorectal carcinogenesis.
Endoplasmic Reticulum Chaperone Calmegin Is Upregulated in Aldosterone-Producing Adenoma and Associates With Aldosterone Production.
Endoplasmic reticulum chaperone GRP78/BiP is critical for mutant Kras-driven lung tumorigenesis.
Glucose regulated protein 78 (GRP78) is overexpressed in colorectal carcinoma and regulates colorectal carcinoma cell growth and apoptosis.
Heterozygosity of chaperone Grp78 reduces intestinal stem cell regeneration potential and protects against adenoma formation.
Immunohistochemical evaluation of expression of heat shock proteins HSP70 and HSP90 in mammary gland neoplasms in bitches.
Impact of USP8 Gene Mutations on Protein Deregulation in Cushing Disease.
Overexpression of glucose-regulated protein 78 in colon cancer.
Overexpression of GRP78 and GRP94 are markers for aggressive behavior and poor prognosis in gastric carcinomas.
Overexpression of GRP78 and GRP94 is involved in colorectal carcinogenesis.
Protein western array analysis in human pituitary tumours: insights and limitations.
Quantitative patterns of Hsps in tubular adenoma compared with normal and tumor tissues reveal the value of Hsp10 and Hsp60 in early diagnosis of large bowel cancer.
Regression of intestinal adenomas by vaccination with heat shock protein 105-pulsed bone marrow-derived dendritic cells in Apc(Min/+) mice.
Adenoma, Islet Cell
Inhibition of Heat Shock Protein 90 with AUY922 Represses Tumor Growth in a Transgenic Mouse Model of Islet Cell Neoplasms.
Adenoma, Liver Cell
Characteristic upregulation of glucose-regulated protein 78 in an early lesion negative for hitherto established cytochemical markers in rat hepatocarcinogenesis.
Combined use of heat-shock protein 70 and glutamine synthetase is useful in the distinction of typical hepatocellular adenoma from atypical hepatocellular neoplasms and well-differentiated hepatocellular carcinoma.
Hepatocellular carcinoma arising in adenoma: similar immunohistochemical and cytogenetic features in adenoma and hepatocellular carcinoma portions of the tumor.
Adenomatous Polyposis Coli
GRP78 enhances the glutamine metabolism to support cell survival from glucose deficiency by modulating the ?-catenin signaling.
Protein disulfide bond formation in the cytoplasm during oxidative stress.
The origins of rimmed vacuoles and granulovacuolar degeneration bodies are associated with the Wnt signaling pathway.
Adenomyosis
Decreased expression of human heat shock protein 70 in the endometria and pathological lesions of women with adenomyosis and uterine myoma after GnRH agonist therapy.
Distribution of heat shock proteins in eutopic and ectopic endometrium in endometriosis and adenomyosis.
Adenosarcoma
Inhibition of heat shock protein 90 destabilizes receptor tyrosine kinase ROR1 in lung adenocarcinoma.
Adrenocortical Carcinoma
A novel heat shock protein 90 inhibitor potently targets adrenocortical carcinoma tumor suppression.
Heat Shock Protein 90 as a Prognostic Marker and Therapeutic Target for Adrenocortical Carcinoma.
Hsp90 inhibition in adrenocortical carcinoma: Limited drug synergism with mitotane.
Potent antitumor activity of HSP90 inhibitor AUY922 in adrenocortical carcinoma.
Adrenoleukodystrophy
Heat shock protein expression in cerebral X-linked adrenoleukodystrophy reveals astrocyte stress prior to myelin loss.
African Swine Fever
The African swine fever virus nonstructural protein pB602L is required for formation of the icosahedral capsid of the virus particle.
Aggressive Periodontitis
Association between circulating levels of heat-shock protein 27 and aggressive periodontitis.
Agranulocytosis
HSP70-2 9.0 kb variant is in linkage disequilibrium with the HLA-B and DRB1* alleles associated with clozapine-induced agranulocytosis.
Mechanism of clozapine-induced agranulocytosis : current status of research and implications for drug development.
The major histocompatibility complex region marked by HSP70-1 and HSP70-2 variants is associated with clozapine-induced agranulocytosis in two different ethnic groups.
Albuminuria
Heat shock protein 70 and albuminuria in patients with type 2 diabetes: a matched case control study.
Levels of circulating GRP78 and CHOP in endoplasmic reticulum stress pathways in Chinese type 2 diabetic kidney disease patients.
Protective role of podocyte autophagy against glomerular endothelial dysfunction in diabetes.
The lost correlation between heat shock protein 70 (HSPA1A) and plasminogen activator inhibitor-1 in patients with type 2 diabetes and albuminuria.
Alexander Disease
Adolescent case of Alexander disease: MR imaging and MR spectroscopy.
Alpha B-crystallin and 27-kd heat shock protein are regulated by stress conditions in the central nervous system and accumulate in Rosenthal fibers.
Clinical aspects and pathology of Alexander disease, and morphological and functional alteration of astrocytes induced by GFAP mutation.
Cytokines and growth factors induce HSP27 phosphorylation in human astrocytes.
Oligomers of mutant glial fibrillary acidic protein (GFAP) Inhibit the proteasome system in alexander disease astrocytes, and the small heat shock protein alphaB-crystallin reverses the inhibition.
Positron emission tomography in juvenile Alexander disease.
Alkalosis
Heat shock protein synthesis is affected by intracellular pH: inhibition by monensin-induced alkalosis in C6 rat glioma cells.
Pre-exercise alkalosis attenuates the heat shock protein 72 response to a single-bout of anaerobic exercise.
The influence of exogenous carbohydrate provision and pre-exercise alkalosis on the heat shock protein response to prolonged interval cycling.
Alopecia
Recombinant human Cyclophilin A stimulates hair follicle cells via Wnt/?-catenin signaling pathway.
Alphavirus Infections
Proteomic Discovery of VEEV E2-Host Partner Interactions Identifies GRP78 Inhibitor HA15 as a Potential Therapeutic for Alphavirus Infections.
Altitude Sickness
High altitude hypoxia on brain ultrastructure of rats and Hsp70 expression changes.
[Relationship between heat stress protein 70 gene polymorphisms and the risk of acute mountain sickness]
Alveolar Bone Loss
Porphyromonas gingivalis heat shock protein vaccine reduces the alveolar bone loss induced by multiple periodontopathogenic bacteria.
Alveolitis, Extrinsic Allergic
Expression of heat shock protein 72 by alveolar macrophages in hypersensitivity pneumonitis.
Alzheimer Disease
A CNS-permeable Hsp90 inhibitor rescues synaptic dysfunction and memory loss in APP-overexpressing Alzheimer's mouse model via an HSF1-mediated mechanism.
A hypothesis on the aetiology of Alzheimer's disease: description of a model involving a misfolded chaperone.
A New Motif in the N-Terminal of Acetylcholinesterase Triggers Amyloid-? Aggregation and Deposition.
A non-toxic Hsp90 inhibitor protects neurons from Abeta-induced toxicity.
Acceleration of TDP43 and FUS/TLS protein expressions in the preconditioned hippocampus following repeated transient ischemia.
Acupuncture promotes expression of Hsp84/86 and delays brain ageing in SAMP8 mice.
Alpha 1-antichymotrypsin gene polymorphism and risk for Alzheimer's disease.
Alpha B crystallin and HSP28 are enhanced in the cerebral cortex of patients with Alzheimer's disease.
Aluminium exposure induces Alzheimer's disease-like histopathological alterations in mouse brain.
Amyloid fibrils composed of hexameric peptides attenuate neuroinflammation.
Analysis of HSPA8 and HSPA9 mRNA Expression and Promoter Methylation in the Brain and Blood of Alzheimer's Disease Patients.
Analysis of the Tau-Associated Proteome Reveals That Exchange of Hsp70 for Hsp90 Is Involved in Tau Degradation.
Applying Hsp104 to protein-misfolding disorders.
Association of HSP70 and its Co-Chaperones with Alzheimer's Disease.
BDNF, TNF?, HSP90, CFH, and IL-10 Serum Levels in Patients with Early or Late Onset Alzheimer's Disease or Mild Cognitive Impairment.
Binding of the molecular chaperone ?B-crystallin to A? amyloid fibrils inhibits fibril elongation.
Chaperones increase association of tau protein with microtubules.
Clusterin ameliorates tau pathology in vivo by inhibiting fibril formation.
Clusterin as a therapeutic target.
Decrease of neuronal FKBP4/FKBP52 modulates perinuclear lysosomal positioning and MAPT/Tau behavior during MAPT/Tau-induced proteotoxic stress.
Development of GMP-1 a molecular chaperone network modulator protecting mitochondrial function and its assessment in fly and mice models of Alzheimer's disease.
Down-regulation of mortalin exacerbates A?-mediated mitochondrial fragmentation and dysfunction.
Elevated risks for amyotrophic lateral sclerosis and blood disorders in Ashkenazi schizophrenic pedigrees suggest new candidate genes in schizophrenia.
ER chaperone-metal interactions: Links to protein folding disorders.
Expression of the human groEL stress-protein homologue in the brain and spinal cord.
Heat Shock Cognate 70 Inhibitor, VER-155008, Reduces Memory Deficits and Axonal Degeneration in a Mouse Model of Alzheimer's Disease.
Heat shock protein 70 and tumor necrosis factor alpha in Taiwanese patients with dementia.
Heat shock protein 70 in Alzheimer's disease.
Heat shock protein 90 in Alzheimer's disease.
Heat shock protein 90: its inhibition and function.
Heat shock protein 90: translation from cancer to Alzheimer's disease treatment?
Heat Shock Protein Inspired Nanochaperones Restore Amyloid-? Homeostasis for Preventative Therapy of Alzheimer's Disease.
Heat shock proteins 70 and 90 inhibit early stages of amyloid beta-(1-42) aggregation in vitro.
Heat-shock protein 70 levels in brain of patients with Down syndrome and Alzheimer's disease.
Hot off the Press.
HSP70-2 (HSPA1B) is associated with noncognitive symptoms in late-onset Alzheimer's disease.
Hsp90 and Its Co-Chaperones in Neurodegenerative Diseases.
Hsp90 inhibitor HSP990 in very low dose upregulates EAAT2 and exerts potent antiepileptic activity.
Hsp90 modulation for the treatment of Alzheimer's disease.
Hsp90 regulates tau pathology through co-chaperone complexes in Alzheimer's disease.
HSPA9/Mortalin mediates axo-protection and modulates mitochondrial dynamics in neurons.
Human olfactory receptor neurons express heat shock protein 70: age-related trends.
Intake of ?-6 Polyunsaturated Fatty Acid-Rich Vegetable Oils and Risk of Lifestyle Diseases.
Lack of association of mortalin (HSPA9) and other mitochondria-related genes with risk of Parkinson's and Alzheimer's diseases.
Linking HSP90 target occupancy to HSP70 induction and efficacy in mouse brain.
Low endogenous and chemical induced heat shock protein induction in a 0N3Rtau-expressing Drosophila larval model of Alzheimer's disease.
Metformin activates chaperone-mediated autophagy and improves disease pathologies in an Alzheimer disease mouse model.
MicroRNA-425-5p promotes tau phosphorylation and cell apoptosis in Alzheimer's disease by targeting heat shock protein B8.
Molecular Chaperone Accumulation in Cancer and Decrease in Alzheimer's Disease: The Potential Roles of HSF1.
Molecular chaperone inducer: a possible treatment for Alzheimer disease.
Mortalin is Expressed by Astrocytes and Decreased in the Midbrain of Parkinson's Disease Patients.
Presenilin-1 mutations downregulate the signalling pathway of the unfolded-protein response.
Probing the mechanism of inhibition of amyloid-?(1-42)-induced neurotoxicity by the chaperonin GroEL.
Recent Advances in Stereoselective Drug Targeting.
Small heat shock protein HspB8: its distribution in Alzheimer's disease brains and its inhibition of amyloid-beta protein aggregation and cerebrovascular amyloid-beta toxicity.
Stressing Out Hsp90 in Neurotoxic Proteinopathies.
Sulforaphane Upregulates the Heat Shock Protein Co-Chaperone CHIP and Clears Amyloid-? and Tau in a Mouse Model of Alzheimer's Disease.
Targeting Hsp90 and its co-chaperones to treat Alzheimer's disease.
Targeting Hsp90/Hsp70-based protein quality control for treatment of adult onset neurodegenerative diseases.
The Down-Regulation of Clusterin Expression Enhances the ?Synuclein Aggregation Process.
The Mitochondrial Hsp90 TRAP1 and Alzheimer's Disease.
The Molecular Chaperone GRP78/BiP as a Therapeutic Target for Neurodegenerative Disorders: A Mini Review.
The Synergistic Effects of Heat Shock Protein 70 and Ginsenoside Rg1 against Tert-Butyl Hydroperoxide Damage Model In Vitro.
The Ubiquitin-Proteasome System and Molecular Chaperone Deregulation in Alzheimer's Disease.
[Heat-shock protein HSP70 decreases activity of proteasomes in human neuroblastoma cells treated by amyloid-beta 1-42 with isomerized Asp7].
Amebiasis
A Novel C-Terminal Homologue of Aha1 Co-Chaperone Binds to Heat Shock Protein 90 and Stimulates Its ATPase Activity in Entamoeba histolytica.
Hsp90 inhibitors as new leads to target parasitic diarrheal diseases.
Humoral immune response against a 70-kilodalton heat shock protein of Entamoeba histolytica in a group of patients with invasive amoebiasis.
Ameloblastoma
Immunohistochemical analysis of inducible nitric oxide synthase (iNOS) and heat shock proteins (HSPs) in ameloblastomas.
Overexpression and extra-mitochondrial localization of the chaperonin Hsp60 in ameloblastoma.
Amyloidosis
Applying Hsp104 to protein-misfolding disorders.
Enhanced molecular chaperone activity of the small heat-shock protein ?B-crystallin following covalent immobilization onto a solid-phase support.
Hsp104 antagonizes alpha-synuclein aggregation and reduces dopaminergic degeneration in a rat model of Parkinson disease.
Hsp104: a weapon to combat diverse neurodegenerative disorders.
Proteome analysis of cerebrospinal fluid in Guillain-Barré syndrome (GBS).
Amyotrophic Lateral Sclerosis
Acceleration of TDP43 and FUS/TLS protein expressions in the preconditioned hippocampus following repeated transient ischemia.
Administration of Recombinant Heat Shock Protein 70 Delays Peripheral Muscle Denervation in the SOD1(G93A) Mouse Model of Amyotrophic Lateral Sclerosis.
Arimoclomol at dosages up to 300 mg/day is well tolerated and safe in amyotrophic lateral sclerosis.
Arimoclomol: a potential therapy under development for ALS.
Calcium-dependent protein folding in amyotrophic lateral sclerosis.
Characterization and Hsp104-induced artificial clearance of familial ALS-related SOD1 aggregates.
Decrease of Hsp25 protein expression precedes degeneration of motoneurons in ALS-SOD1 mice.
Exogenous delivery of heat shock protein 70 increases lifespan in a mouse model of amyotrophic lateral sclerosis.
Expression of an endoplasmic reticulum-resident chaperone, glucose-regulated stress protein 78, in the spinal cord of a mouse model of amyotrophic lateral sclerosis.
High threshold for induction of the stress response in motor neurons is associated with failure to activate HSF1.
Mechanistic Insights into Hsp104 Potentiation.
Molecular Chaperone Mediated Late-Stage Neuroprotection in the SOD1(G93A) Mouse Model of Amyotrophic Lateral Sclerosis.
Neuropathy-causing mutations in HSPB1 impair autophagy by disturbing the formation of SQSTM1/p62 bodies.
Nitration of Hsp90 induces cell death.
Proline/arginine dipeptide repeat polymers derail protein folding in amyotrophic lateral sclerosis.
Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells.
Rapidly progressive amyotrophic lateral sclerosis is associated with microglial reactivity and small heat shock protein expression in reactive astrocytes.
The small heat shock protein B8 (HspB8) promotes autophagic removal of misfolded proteins involved in amyotrophic lateral sclerosis (ALS).
Trehalose induces autophagy via lysosomal-mediated TFEB activation in models of motoneuron degeneration.
Ubiquitin and heat shock protein expression in amyotrophic lateral sclerosis.
VCP maintains lysosomal homeostasis and TFEB activity in differentiated skeletal muscle.
[Effect of electroacupuncture on expression of heat shock protein 70 in mice with amyotrophic lateral sclerosis].
Anaphylaxis
Anaphylactic reaction induced by Toxoplasma gondii-derived heat shock protein 70.
Protective immunity against lethal anaphylactic reaction in Toxoplasma gondii-infected mice by DNA vaccination with T. gondii-derived heat shock protein 70 gene.
Toxoplasma gondii-derived heat shock protein 70 induces lethal anaphylactic reaction through activation of cytosolic phospholipase A2 and platelet-activating factor via Toll-like receptor 4/myeloid differentiation factor 88.
Anaplasmosis
Diverse tick-borne microorganisms identified in free-living ungulates in Slovakia.
Anemia
Changes in the expression of the heme-regulated eIF-2 alpha kinase and heat shock proteins in rabbit reticulocytes maturing during recovery from anemia.
Dietary supplementation of brown seaweed (Sargassum latifolium) alleviates the environmental heat stress-induced toxicity in male Barki sheep (Ovis aries).
HSP90 Shapes the Consequences of Human Genetic Variation.
Molecular pathogenesis of myelodysplastic syndromes with deletion 5q.
Responses of HSC70 expression in diencephalon to iron deficiency anemia in rats.
Subcellular localization and interactions of Infectious Salmon Anemia Virus (ISAV) M1 and NEP as well as host Hsc70.
Susceptibility of heat shock protein 70.1-deficient C57BL/6 J, wild-type C57BL/6 J and A/J mice to Trypanosoma congolense infection.
The haem-regulated eukaryotic initiation factor 2alpha kinase: a molecular indicator of lead-toxicity anaemia in rabbits.
Anemia, Aplastic
High inducibility of heat shock protein 72 (hsp72) in peripheral blood mononuclear cells of aplastic anaemia patients: a reliable marker of immune-mediated aplastic anaemia responsive to cyclosporine therapy.
Anemia, Diamond-Blackfan
The severe phenotype of Diamond-Blackfan anemia is modulated by heat shock protein 70.
Anemia, Hypochromic
First Report of Tomato chlorosis virus Infecting Tomato Crops in Brazil.
Inactivation of the clpC1 gene encoding a chloroplast Hsp100 molecular chaperone causes growth retardation, leaf chlorosis, lower photosynthetic activity, and a specific reduction in photosystem content.
Inducible transgenic tobacco system to study the mechanisms underlying chlorosis mediated by the silencing of chloroplast heat shock protein 90.
Low Genetic Diversity Suggests a Single Introduction and Recent Spread of Tomato chlorosis virus in Brazil
Anemia, Iron-Deficiency
Responses of HSC70 expression in diencephalon to iron deficiency anemia in rats.
Anemia, Sickle Cell
Sickle cell vaso-occlusive crisis induces the release of circulating serum heat shock protein-70.
Anemia, Sideroblastic
Congenital sideroblastic anemia due to mutations in the mitochondrial HSP70 homologue HSPA9.
Aneurysm
Chronic ingestion of high dosed Phikud Navakot extraction induces mesangiolysis in rats with alteration of AQP1 and Hsp60 expressions.
Aneurysm, Dissecting
Heat shock protein 27 plays a protective role in thoracic aortic dissection by promoting cell proliferation and inhibiting apoptosis.
HSP90 inhibitor 17-DMAG effectively alleviated the progress of thoracic aortic dissection by suppressing smooth muscle cell phenotypic switch.
Angina, Unstable
Chronic infections and histamine, CRP and IL-6 levels after percutaneous transluminal coronary angioplasty.
Implications of antibodies to heat-shock proteins in ischemic heart disease.
Serum levels of anti heat shock protein 70 antibodies in patients with stable and unstable angina pectoris.
Unstable angina activates myocardial heat shock protein 72, endothelial nitric oxide synthase, and transcription factors NFkappaB and AP-1.
[Heat shock protein antibodies and other chlamydial antigens in various diseases and their occurrence in blood donors]
Angioedemas, Hereditary
Cytokine and estrogen stimulation of endothelial cells augments activation of the prekallikrein-high molecular weight kininogen complex: Implications for hereditary angioedema.
Angiofibroma
Identification of Heat Shock Protein 90 as a Recurrence Related Marker in Juvenile Nasopharyngeal Angiofibroma.
Anophthalmos
Hsp90 selectively modulates phenotype in vertebrate development.
Anthrax
GroEL as a molecular scaffold for structural analysis of the anthrax toxin pore.
GroEL provides protection against Bacillus anthracis infection in BALB/c mice.
GRP78(BiP) facilitates the cytosolic delivery of anthrax lethal factor (LF) in vivo and functions as an unfoldase in vitro.
Recombinant GroEL enhances protective antigen-mediated protection against Bacillus anthracis spore challenge.
Role of CypA and Hsp90 in membrane translocation mediated by anthrax Protective Antigen.
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
Intense immunostaining of heat shock protein 70 within renal interstitium associates with long-term renal survival in an ANCA-associated vasculitis cohort.
Antiphospholipid Syndrome
Elevation of the 90 kDa heat-shock protein in specific subsets of systemic lupus erythematosus.
Anuria
Heat shock protein 60 is released in immune-mediated glomerulonephritis and aggravates disease: in vivo evidence for an immunologic danger signal.
Aortic Aneurysm
Proteomic alterations in heat shock protein 27 and identification of phosphoproteins in ascending aortic aneurysm associated with bicuspid and tricuspid aortic valve.
Aortic Aneurysm, Abdominal
Heat Shock Protein 90 Inhibition by 17-DMAG Attenuates Abdominal Aortic Aneurysm Formation in Mice.
Plasma heat shock protein 27 is associated with coronary artery disease, abdominal aortic aneurysm and peripheral artery disease.
Targeting HSP90 attenuates angiotensin II-induced adventitial remodeling via suppression of mitochondrial fission.
Aortic Valve Disease
Heat shock protein 90 is downregulated in calcific aortic valve disease.
Aortic Valve Stenosis
Heat shock protein 90 is downregulated in calcific aortic valve disease.
Apnea
Heat Shock Protein HSP70 in Oxidative Stress in Apnea Patients.
Appendicitis
[Content of antibodies to heat shock proteins in uncomplicated and complicated course of acute appendicitis].
Arrhythmogenic Right Ventricular Dysplasia
Proteomic analysis reveals significant elevation of heat shock protein 70 in patients with chronic heart failure due to arrhythmogenic right ventricular cardiomyopathy.
Arteriosclerosis
Enhanced Susceptibility to 5-Fluorouracil in Human Colon Cancer Cells by Silencing of GRP78.
Induction of arteriosclerosis in normocholesterolemic rabbits by immunization with heat shock protein 65.
Inhibition of arteriosclerosis by T-cell depletion in normocholesterolemic rabbits immunized with heat shock protein 65.
Arteriosclerosis Obliterans
Expression and clinical significance of HSP27 and its phosphorylation in lower extremity arteriosclerosis obliterans.
Arteriovenous Fistula
Serum osteoprotegerin level is associated with degree of arteriovenous fistula stenosis in patients with hemodialysis.
Arteritis
Serum levels of antibodies to Chlamydia pneumoniae and human HSP60 in giant cell arteritis patients.
Arthritis
A 71-kD heat shock protein (hsp) from Mycobacterium tuberculosis has modulatory effects on experimental rat arthritis.
A conserved mycobacterial heat shock protein (hsp) 70 sequence prevents adjuvant arthritis upon nasal administration and induces IL-10-producing T cells that cross-react with the mammalian self-hsp70 homologue.
A Humanized Monoclonal Antibody against Heat Shock Protein 60 Suppresses Murine Arthritis and Colitis and Skews the Cytokine Balance toward an Anti-Inflammatory Response.
A monoclonal antibody to the mycobacterial 65 kDa heat shock protein (ML 30) binds to cells in normal and arthritic joints of rats.
A novel pathogenic role of the ER chaperone GRP78/BiP in rheumatoid arthritis.
Absence of peripheral blood T cell responses to "shared epitope' containing peptides in recent onset rheumatoid arthritis.
Activation of T cells recognizing self 60-kD heat shock protein can protect against experimental arthritis.
An immunodominant epitope from mycobacterial 65-kDa heat shock protein protects against pristane-induced arthritis.
Anti-Hsp65 antibodies recognize M proteins of group A streptococci.
Antibodies against M. Bovis 65 KDa Heat Shock Protein and Its P180-188 Epitope in Sera of Patients with Juvenile Idiopathic Arthritis.
Antibodies to human HSP60 in patients with juvenile chronic arthritis, diabetes mellitus, and cystic fibrosis.
Antibodies to mycobacterial 65-kDa heat shock protein and other immunodominant antigens in patients with psoriasis.
Antibody response of restricted isotype to heat shock proteins in juvenile chronic arthritis.
Antibody responses to mycobacterial and self heat shock protein 65 in autoimmune arthritis: epitope specificity and implication in pathogenesis.
Antimycobacterial hsp65 and rheumatoid factor titres in a population of normal twins: evidence of genetic control of rheumatoid factor.
Autoimmune reactions to heat-shock proteins in pristane-induced arthritis.
Autoreactivity to human heat-shock protein 60 predicts disease remission in oligoarticular juvenile rheumatoid arthritis.
Bystander suppression of experimental arthritis by nasal administration of a heat shock protein peptide.
CD4+ Th2 cells specific for mycobacterial 65-kilodalton heat shock protein protect against pristane-induced arthritis.
Cellular and humoral reactivity pattern to the mycobacterial heat shock protein hsp65 in pristane induced arthritis susceptible and hsp65 protected DBA/1 mice.
Characterization of the heat shock response and identification of heat shock protein antigens of Borrelia burgdorferi.
Comparison between the protective effects of mycobacterial 65-kD heat shock protein and ovomucoid in pristane-induced arthritis: relationship with agalactosyl IgG.
DNA vaccine containing the mycobacterial hsp65 gene prevented insulitis in MLD-STZ diabetes.
Effect of hyaluronan oligosaccharides on the expression of heat shock protein 72.
Environmental modulation of autoimmune arthritis involves the spontaneous microbial induction of T cell responses to regulatory determinants within heat shock protein 65.
Expression of mammalian 60-kD heat shock protein in the joints of mice with pristane-induced arthritis.
Frequency of anti-hsp60, -65 and -70 antibodies in sera of patients with juvenile idiopathic arthritis.
Gastric administration of recombinant 65 kDa heat shock protein delays the severity of type II collagen induced arthritis in mice.
Heat shock protein 60 and adjuvant arthritis: a model for T cell regulation in human arthritis.
Heat shock protein 60 inhibits Th1-mediated hepatitis model via innate regulation of Th1/Th2 transcription factors and cytokines.
Heat shock protein 60 reactive T cells in juvenile idiopathic arthritis: what is new?
Heat shock protein 65-reactive T cells are involved in the pathogenesis of non-antigenic dimethyl dioctadecyl ammonium bromide-induced arthritis.
Heat shock protein 70 membrane expression on fibroblast-like synovial cells derived from synovial tissue of patients with rheumatoid and juvenile idiopathic arthritis.
Heat shock protein expression is low in intestinal mucosa in juvenile idiopathic arthritis: a defect in immunoregulation?
Heat shock proteins as potential targets in the therapy of inflammatory arthritis.
Heat-shock proteins as immunogenic bacterial antigens with the potential to induce and regulate autoimmune arthritis.
Highly autoproliferative T cells specific for 60-kDa heat shock protein produce IL-4/IL-10 and IFN-gamma and are protective in adjuvant arthritis.
HSP60 Regulates Monosodium Urate Crystal-Induced Inflammation by Activating the TLR4-NF-?B-MyD88 Signaling Pathway and Disrupting Mitochondrial Function.
Humoral response against Mycobacterium bovis Hsp65 derived fragments in children and young people with various disorders.
IgG and IgA antibody titers against human heat-shock protein (hsp60) in sera of rheumatoid arthritis and osteoarthritis patients.
In Vitro and In Vivo Studies of the Biological Effects of Bioceramic (a Material of Emitting High Performance Far-Infrared Ray) Irradiation.
In vitro responses to a 65-kilodalton mycobacterial protein by synovial T cells from inflammatory arthritis patients.
Incidence of anti Hsp 90 and 70 antibodies in children with SLE, juvenile dermatomyositis and juvenile chronic arthritis.
Inhibition of adjuvant-induced arthritis by nasal administration of novel synthetic peptides from heat shock protein 65.
Juvenile chronic arthritis: T cell reactivity to human HSP60 in patients with a favorable course of arthritis.
Juvenile idiopathic arthritis and HSP60 vaccination: selective down-regulation?
Juvenile rheumatoid arthritis patients manifest immune reactivity to the mycobacterial 65-kDa heat shock protein, to its 180-188 peptide, and to a partially homologous peptide of the proteoglycan link protein.
Kruppel-like factor 2 (KLF2) regulates monocyte differentiation and functions in mBSA and IL-1?-induced arthritis.
Modulation of adjuvant arthritis in Lewis rats by recombinant vaccinia virus expressing the human 60-kilodalton heat shock protein.
Mycobacterial heat shock protein 70 induces interleukin-10 production: immunomodulation of synovial cell cytokine profile and dendritic cell maturation.
Natural Withanolides in the Treatment of Chronic Diseases.
Oral administration of HSP-containing E. coli extract OM-89 has suppressive effects in autoimmunity. Regulation of autoimmune processes by modulating peripheral immunity towards hsp's?
Peptide-induced nasal tolerance for a mycobacterial heat shock protein 60 T cell epitope in rats suppresses both adjuvant arthritis and nonmicrobially induced experimental arthritis.
Peripheral blood mononuclear cell responses to heat shock proteins and their derived synthetic peptides in juvenile idiopathic arthritis patients.
Protection against streptococcal cell wall-induced arthritis by pretreatment with the 65-kD mycobacterial heat shock protein.
Protection of rats from adjuvant arthritis by immunization with naked DNA encoding for mycobacterial heat shock protein 65.
Recognition of human 60 kD heat shock protein by mononuclear cells from patients with juvenile chronic arthritis.
Responses to gram negative enteric bacterial antigens by synovial T cells from patients with juvenile chronic arthritis: recognition of heat shock protein HSP60.
Role of endoplasmic reticulum stress in rheumatoid arthritis pathogenesis.
Self heat-shock protein 65-mediated regulation of autoimmune arthritis.
Serum heat shock protein 60 can predict remission of flare-up in juvenile idiopathic arthritis.
Specific immunity as a critical factor in the control of autoimmune arthritis: the example of hsp60 as an ancillary and protective autoantigen.
Stimulation of suppressive T cell responses by human but not bacterial 60-kD heat-shock protein in synovial fluid of patients with rheumatoid arthritis.
Stimulation of synovial fluid mononuclear cells with the human 65-kD heat shock protein or with live enterobacteria leads to preferential expansion of TCR-gamma delta+ lymphocytes.
Stress proteins are used by the immune system for cognate interactions with anti-inflammatory regulatory T cells.
Stress proteins, autoimmunity, and autoimmune disease.
Subcellular localization of the 65-kDa heat shock protein in mycobacteria by immunoblotting and immunogold ultracytochemistry.
Susceptibility to pristane-induced arthritis is altered with changes in bowel flora.
Synovial fluid T cell reactivity against 65 kD heat shock protein of mycobacteria in early chronic arthritis.
T-cell reactivity to human HSP60 in oligo-articular juvenile chronic arthritis is associated with a favorable prognosis and the generation of regulatory cytokines in the inflamed joint.
The human endoplasmic reticulum molecular chaperone BiP is an autoantigen for rheumatoid arthritis and prevents the induction of experimental arthritis.
The regulatory C-terminal determinants within mycobacterial heat shock protein 65 are cryptic and cross-reactive with the dominant self homologs: implications for the pathogenesis of autoimmune arthritis.
The role of heat shock protein in the persistence of arthritis.
Therapeutic effect of recombinant vaccinia virus expressing the 60-kd heat-shock protein on adjuvant arthritis.
Three cases of arthritis after BCG therapy for bladder cancer.
TLR9 agonist CpG enhances protective nasal HSP60 peptide vaccine efficacy in experimental autoimmune arthritis.
Tolerogenic immune responses to novel T-cell epitopes from heat-shock protein 60 in juvenile idiopathic arthritis.
Two monoclonal antibodies generated against human hsp60 show reactivity with synovial membranes of patients with juvenile chronic arthritis.
V1.2. recognition of multiple hsp60 epitopes in patients with juvenile idiopathic arthritis opens the way for antigen-specific immunotherapy.
Vaccination with endosomal unknown epitopes produces therapeutic response in rheumatoid arthritis patients and modulates adjuvant arthritis of rats.
Yersinia-associated arthritis in rats: effect of 65 kDa heat shock protein, bovine serum albumin and incomplete Freund's adjuvant.
Arthritis, Experimental
A conserved mycobacterial heat shock protein (hsp) 70 sequence prevents adjuvant arthritis upon nasal administration and induces IL-10-producing T cells that cross-react with the mammalian self-hsp70 homologue.
A constitutive 65 kDa chondrocyte protein as a target antigen in adjuvant arthritis in Lewis rats.
A Humanized Monoclonal Antibody against Heat Shock Protein 60 Suppresses Murine Arthritis and Colitis and Skews the Cytokine Balance toward an Anti-Inflammatory Response.
A monoclonal antibody to the mycobacterial 65 kDa heat shock protein (ML 30) binds to cells in normal and arthritic joints of rats.
A mycobacterial 65-kD heat shock protein induces antigen-specific suppression of adjuvant arthritis, but is not itself arthritogenic.
A self-hsp60 peptide acts as a partial agonist inducing expression of B7-2 on mycobacterial hsp60-specific T cells: a possible mechanism for inhibitory T cell regulation of adjuvant arthritis?
A synthetic 10-kD heat shock protein (hsp10) from Mycobacterium tuberculosis modulates adjuvant arthritis.
A synthetic mycobacterial heat shock peptide prevents adjuvant arthritis but not proteoglycan-induced synovitis in the rat.
Activation of T cells recognizing an epitope of heat-shock protein 70 can protect against rat adjuvant arthritis.
Adjuvant arthritis and immunity to the mycobacterial 65 kDa heat shock protein.
Antibody levels to mycobacteria in relation to HLA type: evidence for non-HLA-linked high levels of antibody to the 65 kD heat shock protein of M. bovis in rheumatoid arthritis.
Antibody reactivity to mycobacterial 65 kDa heat shock protein: relevance to autoimmunity.
Cellular and humoral reactivity pattern to the mycobacterial heat shock protein HSP65 in adjuvant arthritis susceptible and resistant Wistar rats.
Differential mycobacterial 65-kDa heat shock protein T cell epitope recognition after adjuvant arthritis-inducing or protective immunization protocols.
Diversification of response to hsp65 during the course of autoimmune arthritis is regulatory rather than pathogenic.
DNA fragments of the human 60-kDa heat shock protein (HSP60) vaccinate against adjuvant arthritis: identification of a regulatory HSP60 peptide.
Generation and characterization of a clonotypic antibody specific for the T cell receptor of an arthritogenic T cell clone--studies in adjuvant arthritis.
Highly autoproliferative T cells specific for 60-kDa heat shock protein produce IL-4/IL-10 and IFN-gamma and are protective in adjuvant arthritis.
Inhibition of adjuvant arthritis by a DNA vaccine encoding human heat shock protein 60.
Modulation of adjuvant arthritis in Lewis rats by recombinant vaccinia virus expressing the human 60-kilodalton heat shock protein.
Natural antibodies to 65 kD mycobacterial heat shock protein in rats do not correlate with susceptibility for Mycobacterium tuberculosis induced adjuvant arthritis.
Prevention of adjuvant arthritis in rats by a nonapeptide from the 65-kD mycobacterial heat shock protein: specificity and mechanism.
Preventive administration of Mycobacterium tuberculosis 10-kDa heat shock protein (hsp10) suppresses adjuvant arthritis in Lewis rats.
Protection of rats from adjuvant arthritis by immunization with naked DNA encoding for mycobacterial heat shock protein 65.
Resistance to adjuvant arthritis is due to protective antibodies against heat shock protein surface epitopes and the induction of IL-10 secretion.
Significance of endogenous heat shock protein in adjuvant arthritis.
Strain differences and the role for HSP47 and HSP70 in adjuvant arthritis in rats.
Suppression of adjuvant arthritis in rats by induction of oral tolerance to mycobacterial 65-kDa heat shock protein.
Susceptibility and resistance to experimental adjuvant arthritis.
T cell responses to conserved bacterial heat-shock-protein epitopes induce resistance in experimental autoimmunity.
T-cell response to self HSP60 peptides in renal transplant recipients: a regulatory role?
The beta 2-adrenergic agonist salbutamol potentiates oral induction of tolerance, suppressing adjuvant arthritis and antigen-specific immunity.
The gene expression profile of preclinical autoimmune arthritis and its modulation by a tolerogenic disease-protective antigenic challenge.
The possible role of heat shock protein-70 induction in collagen-induced arthritis in rats.
The regulatory C-terminal determinants within mycobacterial heat shock protein 65 are cryptic and cross-reactive with the dominant self homologs: implications for the pathogenesis of autoimmune arthritis.
Therapeutic effect of recombinant vaccinia virus expressing the 60-kd heat-shock protein on adjuvant arthritis.
Towards peptide immunotherapy in rheumatoid arthritis: competitor-modulator concept.
Treatment of adjuvant arthritis in rats: vaccination potential of a synthetic nonapeptide from the 65 kDa heat shock protein of mycobacteria.
Treatment of adjuvant arthritis with granulocyte-colony stimulating factor and peptide derived from heat shock protein 65.
Arthritis, Gouty
Capillary Electrophoresis with Laser Induced Fluorescence Detection for Study of the Association of HSP60 Gene Polymorphism with Gouty Arthritis.
Arthritis, Juvenile
Antibodies against M. Bovis 65 KDa Heat Shock Protein and Its P180-188 Epitope in Sera of Patients with Juvenile Idiopathic Arthritis.
Antibodies to human HSP60 in patients with juvenile chronic arthritis, diabetes mellitus, and cystic fibrosis.
Antibody response of restricted isotype to heat shock proteins in juvenile chronic arthritis.
Autoreactivity to human heat-shock protein 60 predicts disease remission in oligoarticular juvenile rheumatoid arthritis.
Frequency of anti-hsp60, -65 and -70 antibodies in sera of patients with juvenile idiopathic arthritis.
Heat shock protein 70 membrane expression on fibroblast-like synovial cells derived from synovial tissue of patients with rheumatoid and juvenile idiopathic arthritis.
Heat shock protein expression is low in intestinal mucosa in juvenile idiopathic arthritis: a defect in immunoregulation?
Heat-shock proteins as immunogenic bacterial antigens with the potential to induce and regulate autoimmune arthritis.
Humoral response against Mycobacterium bovis Hsp65 derived fragments in children and young people with various disorders.
Immune responses to the Escherichia coli dnaJ heat shock protein in juvenile rheumatoid arthritis and their correlation with disease activity.
Incidence of anti Hsp 90 and 70 antibodies in children with SLE, juvenile dermatomyositis and juvenile chronic arthritis.
Juvenile chronic arthritis: T cell reactivity to human HSP60 in patients with a favorable course of arthritis.
Juvenile idiopathic arthritis and HSP60 vaccination: selective down-regulation?
Juvenile rheumatoid arthritis patients manifest immune reactivity to the mycobacterial 65-kDa heat shock protein, to its 180-188 peptide, and to a partially homologous peptide of the proteoglycan link protein.
Recognition of human 60 kD heat shock protein by mononuclear cells from patients with juvenile chronic arthritis.
Responses to gram negative enteric bacterial antigens by synovial T cells from patients with juvenile chronic arthritis: recognition of heat shock protein HSP60.
Self heat-shock protein 65-mediated regulation of autoimmune arthritis.
Serum heat shock protein 60 can predict remission of flare-up in juvenile idiopathic arthritis.
T-cell reactivity to human HSP60 in oligo-articular juvenile chronic arthritis is associated with a favorable prognosis and the generation of regulatory cytokines in the inflamed joint.
Tolerogenic immune responses to novel T-cell epitopes from heat-shock protein 60 in juvenile idiopathic arthritis.
Two monoclonal antibodies generated against human hsp60 show reactivity with synovial membranes of patients with juvenile chronic arthritis.
V1.2. recognition of multiple hsp60 epitopes in patients with juvenile idiopathic arthritis opens the way for antigen-specific immunotherapy.
Arthritis, Psoriatic
Autoantibodies to human stress proteins. A survey of various rheumatic and other inflammatory diseases.
Arthritis, Reactive
A single nonamer from the Yersinia 60-kDa heat shock protein is the target of HLA-B27-restricted CTL response in Yersinia-induced reactive arthritis.
Autoantibodies to human heat shock protein (hsp)60 may be induced by Escherichia coli groEL.
Identification and characterization of a DR4-restricted T cell epitope within chlamydia heat shock protein 60.
In vitro responses to a 65-kilodalton mycobacterial protein by synovial T cells from inflammatory arthritis patients.
Induction of abnormal Chlamydia trachomatis by exposure to interferon-gamma or amino acid deprivation and comparative antigenic analysis.
Responses to gram negative enteric bacterial antigens by synovial T cells from patients with juvenile chronic arthritis: recognition of heat shock protein HSP60.
Serum antibodies from patients with ankylosing spondylitis and Reiter's syndrome are reactive with HLA-B27 cells transfected with the Mycobacterium tuberculosis hsp60 gene.
The humoral immune response to Chlamydia trachomatis in patients with acute reactive arthritis.
Arthritis, Rheumatoid
A dominant human leucocyte antigen DR4-Dw15 restricted mycobacterial 65 kDa antigen-specific T-cell immunity in Chinese patients with rheumatoid arthritis.
Aberrant extracellular and dendritic cell (DC) surface expression of heat shock protein (hsp)70 in the rheumatoid joint: possible mechanisms of hsp/DC-mediated cross-priming.
Agalactosyl IgG, antibodies to heat shock proteins, and acute rheumatic fever.
Analysis of 70Kd heat shock protein expression in patients with internal derangement of the temporomandibular joint.
Analysis of human 65 kD heat shock protein mRNA using polymerase chain reaction in synovia of rheumatoid arthritis patients.
Analysis of serum heat shock protein 70 (HSPA1A) concentrations for diagnosis and disease activity monitoring in patients with rheumatoid arthritis.
Antibodies against human 60 kDa heat shock protein are not associated with cardiovascular disease in patients with rheumatoid arthritis.
Antibodies to heat shock protein 65 kD in type 1 diabetes mellitus.
Antibodies to mycobacterial 65 kDa heat shock protein in systemic sclerosis (scleroderma).
Antibodies to the constitutive 73-kd heat shock protein: a new marker of mixed connective tissue disease?
Antibody levels to mycobacteria in relation to HLA type: evidence for non-HLA-linked high levels of antibody to the 65 kD heat shock protein of M. bovis in rheumatoid arthritis.
Antibody reactivity to mycobacterial 65 kDa heat shock protein: relevance to autoimmunity.
Antibody responses to mycobacterial and self heat shock protein 65 in autoimmune arthritis: epitope specificity and implication in pathogenesis.
Antibody to Mycobacterium tuberculosis 65 kDa heat shock protein in patients with rheumatoid arthritis--a survey of antigen-specific antibody isotypes and subclasses in an endemic area of previous tuberculosis infection.
Association between the 65-kilodalton heat shock protein, Streptococcus sanguis, and the corresponding antibodies in Behçet's syndrome.
Association of stress proteins with autoantigens: a possible mechanism for triggering autoimmunity?
Autoantibodies against chaperonin CCT in human sera with rheumatic autoimmune diseases: comparison with antibodies against other Hsp60 family proteins.
Autoantibodies to human heat shock protein (hsp)60 may be induced by Escherichia coli groEL.
Autoantigen BiP and autoimmune diseases.
Autoreactive T cells to citrullinated HSP90 are associated with interstitial lung disease in rheumatoid arthritis.
BiP, a putative autoantigen in rheumatoid arthritis, stimulates IL-10-producing CD8-positive T cells from normal individuals.
Cellular immune response to Klebsiella pneumoniae antigens in patients with HLA-B27+ ankylosing spondylitis.
Chemical inhibition of HSP90 inhibits TNF-? mediated proliferation and induces apoptosis in human rheumatoid arthritis fibroblast-like synoviocytes.
Continuous enhanced expression of Hsc70 but not Hsp70 in rheumatoid arthritis synovial tissue.
Detection of autoantibodies to the pancreatic islet heat shock protein 60 in insulin-dependent diabetes mellitus.
Downregulation of heat shock protein 70 protects rheumatoid arthritis fibroblast-like synoviocytes from nitric oxide-induced apoptosis.
Effect of sulphasalazine on gastrointestinal microflora and on mucosal heat shock protein expression in patients with rheumatoid arthritis.
Elevated IgG antibody levels to the mycobacterial 65-kDa heat shock protein are characteristic of patients with rheumatoid arthritis.
Enhanced expression of heat shock protein 70 (hsp70) and heat shock factor 1 (HSF1) activation in rheumatoid arthritis synovial tissue. Differential regulation of hsp70 expression and hsf1 activation in synovial fibroblasts by proinflammatory cytokines, shear stress, and antiinflammatory drugs.
Epitope specificity and MHC restriction of rheumatoid arthritis synovial T cell clones which recognize a mycobacterial 65 kDa heat shock protein.
Experimental immunization with anti-rheumatic bacterial extract OM-89 induces T cell responses to heat shock protein (hsp)60 and hsp70; modulation of peripheral immunological tolerance as its possible mode of action in the treatment of rheumatoid arthritis (RA).
Expression of heat shock protein on lymphocytes in peripheral blood and synovial fluid from patients with rheumatoid arthritis.
Expression of heat-shock proteins in Streptococcus pyogenes and their immunoreactivity with sera from patients with streptococcal diseases.
Expression of mammalian 60-kD heat shock protein in the joints of mice with pristane-induced arthritis.
Extensive Citrullination Promotes Immunogenicity of HSP90 through Protein Unfolding and Exposure of Cryptic Epitopes.
Geranylgeranylacetone, a non-toxic inducer of heat shock protein, induces cell death in fibroblast-like synoviocytes from patients with rheumatoid arthritis.
Heat shock protein 70 gene polymorphisms in rheumatoid arthritis.
Heat shock protein 70 membrane expression on fibroblast-like synovial cells derived from synovial tissue of patients with rheumatoid and juvenile idiopathic arthritis.
Heat shock protein 90 is required for increased DNA binding activity of activator protein-1, a heterodimer of Fos/JunD, in rheumatoid synovial cells under inflammatory stimuli.
Heat shock protein 90: a pathophysiological factor and novel treatment target in autoimmune bullous skin diseases.
Heat shock protein 96 is elevated in rheumatoid arthritis and activates macrophages primarily via TLR2 signaling.
Heat shock protein gene expression profile may differentiate between rheumatoid arthritis, osteoarthritis, and healthy controls.
Hsp40 proteins modulate humoral and cellular immune response in rheumatoid arthritis patients.
Hsp60 and Hsp10 as Antitumor Molecular Agents.
HSP70-1 promoter region alleles and susceptibility to rheumatoid arthritis.
Human Hsp40 proteins, DNAJA1 and DNAJA2, as potential targets of the immune response triggered by bacterial DnaJ in rheumatoid arthritis.
Identification of small heat shock protein B8 (HSP22) as a novel TLR4 ligand and potential involvement in the pathogenesis of rheumatoid arthritis.
Immune responses to Mycobacterial heat shock protein 70 accompany self-reactivity to human BiP in rheumatoid arthritis.
Immunodominant region of Actinobacillus actinomycetemcomitans 40-kilodalton heat shock protein in patients with rheumatoid arthritis.
In-vitro effects of Mycobacterium bovis BCG-lysate and its derived heat shock proteins on cytokines secretion by blood mononuclear cells of rheumatoid arthritis patients in comparison with healthy controls.
Induction of human hsp60 expression in monocytic cell lines.
Inhibition of antigen-presenting cell function and stimulation of human peripheral blood mononuclear cells to express an antiinflammatory cytokine profile by the stress protein BiP: relevance to the treatment of inflammatory arthritis.
Initiation but no execution - modulation of peripheral blood lymphocyte apoptosis in rheumatoid arthritis - a potential role for heat shock protein 70.
Interference by IgM rheumatoid factor on ELISA for antibodies to mycobacterial 65 kDa heat shock protein in rheumatoid arthritis.
Is Male Rheumatoid Arthritis an Occupational Disease? A Review.
Major differences in antigen-processing correlate with a single Arg71<-->Lys substitution in HLA-DR molecules predisposing to rheumatoid arthritis and with their selective interactions with 70-kDa heat shock protein chaperones.
New perspective on Behçet's disease.
Pan-DR-binding Hsp60 self epitopes induce an interleukin-10-mediated immune response in rheumatoid arthritis.
Predominant immunoreactivity of Porphyromonas gingivalis heat shock protein in autoimmune diseases.
Preferential binding with Escherichia coli hsp60 of antibodies prevalent in sera from patients with rheumatoid arthritis.
Presence of human 65 kD heat shock protein (hsp) in inflamed joints and subcutaneous nodules of RA patients.
Proliferative response of synovial fluid mononuclear cells of patients with rheumatoid arthritis to mycobacterial 65 kDa heat shock protein and its association with HLA-DR+.gamma delta+ T cells.
Protein moonlighting: a new factor in biology and medicine.
Purification of recombinant human Hsp60: use of a GroEL-free preparation to assess autoimmunity in rheumatoid arthritis.
Recognition of human 60 kD heat shock protein by mononuclear cells from patients with juvenile chronic arthritis.
Sequence homologies between hsp60 and autoantigens.
Small molecule inhibitors of Hsp90 potently affect inflammatory disease pathways and exhibit activity in models of rheumatoid arthritis.
Stimulatory response towards the 65 kDa heat shock protein and other mycobacterial antigens in patients with rheumatoid arthritis.
T cell response to human HSP60 and yersinia 19 kDa in ankylosing spondylitis and rheumatoid arthritis: no evidence for a causal role of these antigens in the pathogenesis.
The B cell repertoire of patients with rheumatoid arthritis. Frequencies and specificities of peripheral blood B cells reacting with human IgG, human collagens, a mycobacterial heat shock protein and other antigens.
The human endoplasmic reticulum molecular chaperone BiP is an autoantigen for rheumatoid arthritis and prevents the induction of experimental arthritis.
The regulatory C-terminal determinants within mycobacterial heat shock protein 65 are cryptic and cross-reactive with the dominant self homologs: implications for the pathogenesis of autoimmune arthritis.
The susceptibility sequence to rheumatoid arthritis is a cross-reactive B cell epitope shared by the Escherichia coli heat shock protein dnaJ and the histocompatibility leukocyte antigen DRB10401 molecule.
Treatment with Recombinant Hsp72 Suppresses Collagen-Induced Arthritis in Mice.
Tripterine prevents endothelial barrier dysfunction by inhibiting endogenous peroxynitrite formation.
TXNDC5 synergizes with HSC70 to exacerbate the inflammatory phenotype of synovial fibroblasts in rheumatoid arthritis through NF-?B signaling.
[Autoimmune diseases and stress proteins]
[Research for basic and clinical aspects of Behcet's disease--recent advance and future--]
[The effect of Hsp72 on IL-6, IL-8 expression and activation of NF-kappaB in synoviocytes of rheumatoid arthritis].
Aspergillosis
COVID19 associated mucormycosis: Is GRP78 a possible link?
Heat shock protein 88 and Aspergillus infection.
Heat shock protein 90 (Hsp90): A novel antifungal target against Aspergillus fumigatus.
Identification of a Key Lysine Residue in Heat Shock Protein 90 Required for Azole and Echinocandin Resistance in Aspergillus fumigatus.
In vitro and in vivo role of heat shock protein 90 in Amphotericin B resistance of Aspergillus terreus.
Newer combination antifungal therapies for invasive aspergillosis.
Transcriptional Activation of Heat-Shock Protein 90 (Hsp90) Mediated Via a Proximal Promoter Region Confers Caspofungin Resistance in Aspergillus fumigatus.
Asthenozoospermia
Association of GRP78 promoter polymorphisms and serum GRP78 level with risk of asthenozoospermia.
Membrane bound Glucose Regulated Protein 78 interacts with alpha-2-macroglobulin to promote actin reorganization in sperm during epididymal maturation.
[Asthenozoospermia is not correlated with 3' UTR polymorphisms of the GRP78 gene].
Asthma
Active Ingredients of Epimedii Folium and Ligustri Lucidi Fructus Balanced GR/HSP90 to Improve the Sensitivity of Asthmatic Rats to Budesonide.
Airflow limitation, asthma, and Chlamydia pneumoniae-specific heat shock protein 60.
Alveolar macrophages in allergic asthma: an expression signature characterized by heat shock protein pathways.
An imbalance in antioxidant enzymes and stress proteins in childhood asthma.
An inherent dysfunction in soluble guanylyl cyclase is present in the airway of severe asthmatics and is associated with aberrant redox enzyme expression and compromised NO-cGMP signaling.
Bronchial gamma delta T-lymphocytes and expression of heat shock proteins in mild asthma.
Chlamydia pneumoniae and severity of asthma.
Cross talk between Hsp72, HMGB1 and RAGE/ERK1/2 signaling in the pathogenesis of bronchial asthma in obese patients.
Decreased expression of heat shock protein 20 in colorectal cancer and its implication in tumorigenesis.
Differential DAMP release was observed in the sputum of COPD, asthma and asthma-COPD overlap (ACO) patients.
Erratum to: Increased heat shock protein 70 levels in induced sputum and plasma correlate with severity of asthma patients.
Heat shock protein 70 gene polymorphisms in Japanese patients with aspirin-exacerbated respiratory disease.
Heat shock protein 70 upregulation is related to HLA-DR expression in bronchial asthma. Effects of inhaled glucocorticoids.
Heat shock protein X purified from Mycobacterium tuberculosis enhances the efficacy of dendritic cells-based immunotherapy for the treatment of allergic asthma.
Heat shock proteins mRNA expressions by peripheral blood mononuclear cells in asthma and chronic bronchitis.
Host immune response to Chlamydia pneumoniae heat shock protein 60 is associated with asthma.
Increased expression of heat shock protein 70 on airway cells in asthma and chronic bronchitis.
Increased heat shock protein 70 levels in induced sputum and plasma correlate with severity of asthma patients.
Modification of lung endoplasmic reticulum genes expression and NF-kB protein levels in obese ovalbumin-sensitized male and female rats.
Nitric oxide suppresses LPS-induced inflammation in a mouse asthma model by attenuating the interaction of IKK and Hsp90.
Oral administration of Hsp65-producing Lactococcus lactis attenuates allergic asthma in a murine model.
Plasma antibodies against heat shock protein 70 correlate with the incidence and severity of asthma in a Chinese population.
Regulation of CD23 in the chronic inflammatory response in asthma: a role for interferon-gamma and heat shock protein 70 in the TH2 environment.
The influence of dexamethasone and the role of some antioxidant vitamins in the pathogenesis of experimental bronchial asthma.
The Protective Effects of Helicobacter pylori Infection on Allergic Asthma.
The Role of Heat Shock Protein 70 kDa in Asthma.
Astrocytoma
AP-1 and heat shock protein 27 expression in human astrocytomas.
Association of elevated GRP78 expression with increased astrocytoma malignancy via Akt and ERK pathways.
Comparative non-cholinergic neurotoxic effects of paraoxon and diisopropyl fluorophosphate (DFP) on human neuroblastoma and astrocytoma cell lines.
Dynamic O-GlcNAcylation of the small heat shock protein alpha B-crystallin.
Expression of the small heat shock protein (hsp) 27 in human astrocytomas correlates with histologic grades and tumor growth fractions.
Heat shock protein expression in human gliomas.
HIV-1 Gp120 clade B/C induces a GRP78 driven cytoprotective mechanism in astrocytoma.
Integrated proteomic platforms for the comparative characterization of medulloblastoma and pilocytic astrocytoma pediatric brain tumors: a preliminary study.
NO-induced downregulation of HSP10 and HSP60 expression in the postischemic brain.
Phosphorylated Hsp27 is mutually exclusive with ATRX loss and the IDH1
Potential biomarkers of childhood brain tumor identified by proteomics of cerebrospinal fluid from extraventricular drainage (EVD).
The stress kit: a new method based on competitive reverse transcriptase-polymerase chain reaction to quantify the expression of human alphaB-crystallin, Hsp27, and Hsp60.
The surface-exposed chaperone, Hsp60, is an agonist of the microglial TREM2 receptor.
Asymptomatic Infections
Association analysis of HLA-class II and class III gene polymorphisms in the susceptibility to mediterranean visceral leishmaniasis.
Expression of the 60 kDa heat shock protein in peritoneal fluids from women with endometriosis: implications for endometriosis-associated infertility.
Ataxia
Response of cell cycle/stress-related protein expression and DNA damage upon treatment of CaCo2 cells with anthocyanins.
The neurodegenerative-disease-related protein sacsin is a molecular chaperone.
Ataxia Telangiectasia
Activation of eNOS in endothelial cells exposed to ionizing radiation involves components of the DNA damage response pathway.
Chronic hypoxia in Andeans; are there lessons for neurology at sea level?
Confirmation that variants in TTI2 are responsible for autosomal recessive intellectual disability.
Cooperative Enhancement of Radiosensitivity After Combined Treatment of 17-(Allylamino)-17-Demethoxygeldanamycin and Celecoxib in Human Lung and Colon Cancer Cell Lines.
Differential Expression of Small Heat Shock Protein 27 (Hsp27) in Ataxia telangiectasia Brains.
Hsp90 inhibition has opposing effects on wild-type and mutant p53 and induces p21 expression and cytotoxicity irrespective of p53/ATM status in chronic lymphocytic leukaemia cells.
Hyperthermia activates a subset of ataxia-telangiectasia mutated effectors independent of DNA strand breaks and heat shock protein 70 status.
Interaction of Heat Shock Protein Cpn10 with the Cyclin E/Cdk2 Substrate Nuclear Protein Ataxia-Telangiectasia (NPAT) Is Involved in Regulating Histone Transcription.
Pentose phosphate pathway activation via HSP27 phosphorylation by ATM kinase: A putative endogenous antioxidant defense mechanism during cerebral ischemia-reperfusion.
Temporal changes in mouse aortic wall gene expression during the development of elastase-induced abdominal aortic aneurysms.
Atherosclerosis
A new murine model for atherosclerosis with inflammation in the periodontal tissue induced by immunization with heat shock protein 60.
A novel atherogenic epitope from Mycobacterium tuberculosis heat shock protein 65 enhances atherosclerosis in rabbit and LDL receptor-deficient mice.
A physiologically relevant atherogenic diet causes severe endothelial dysfunction within 4 weeks in rabbit.
A Th2 immune shift to heat shock protein 65 fails to arrest atherosclerosis: Proatherogenic role of Th2-deviated autoantibodies.
Anti-heat shock protein 60 autoantibodies induce atherosclerosis in apolipoprotein E-deficient mice via endothelial damage.
Anti-heat shock protein 70 autoantibody epitope changes and BD091 promotes atherosclerosis in rats.
Anti-HSP60 Immunity Is Already Associated with Atherosclerosis Early in Life.
ApoB-100 and HSP60 Peptides Exert a Synergetic Role in Inhibiting Early Atherosclerosis in Immunized ApoE-null Mice.
Association between antibodies to heat shock protein 65 and coronary atherosclerosis. Possible mechanism of action of Helicobacter pylori and other bacterial infections in increasing cardiovascular risk.
Association of serum-soluble heat shock protein 60 with carotid atherosclerosis: clinical significance determined in a follow-up study.
Atherosclerosis and connective tissue diseases.
Atherosclerosis as a paradigmatic disease of the elderly: role of the immune system.
Atherosclerosis--an autoimmune disease due to an immune reaction against heat-shock protein 60.
Atherosclerotic lesion development and Toll like receptor 2 and 4 responsiveness.
Atorvastatin downregulates HSP22 expression in an atherosclerotic model in vitro and in vivo.
Atorvastatin inhibits CD68 expression in aortic root through a GRP78-involved pathway.
Autoantibodies against heat shock protein 60 mediate endothelial cytotoxicity.
Autoimmune and inflammatory mechanisms in atherosclerosis.
Autoreactive HSP60 epitope-specific T-cells in early human atherosclerotic lesions.
Beta-actin: a regulator of NOS-3.
Biophysical analyses and functional implications of the interaction between Heat Shock Protein 27 and antibodies to HSP27.
Cellular and humoral immune responses to heat shock protein 65 are both involved in promoting fatty-streak formation in LDL-receptor deficient mice.
Changes in heat shock protein 70 localization and its content in rabbit aorta at various stages of experimental atherosclerosis.
Characterization of a natural mouse monoclonal antibody recognizing epitopes shared by oxidized low-density lipoprotein and chaperonin 60 of Aggregatibacter actinomycetemcomitans.
Characterization of HSP27 phosphorylation sites in human atherosclerotic plaque secretome.
Characterization of human anti-heat shock protein 60 monoclonal autoantibody Fab fragments in atherosclerosis: Genetic and functional analysis.
Chlamydia pneumoniae heat shock protein 60 enhances expression of ERK, TLR-4 and IL-8 in atheromatous plaques of coronary artery disease patients.
Chlamydia pneumoniae infection acts as an endothelial stressor with the potential to initiate the earliest heat shock protein 60-dependent inflammatory stage of atherosclerosis.
Chlamydial and human heat shock protein 60s activate human vascular endothelium, smooth muscle cells, and macrophages.
Chronic over-expression of heat shock protein 27 attenuates atherogenesis and enhances plaque remodeling: a combined histological and mechanical assessment of aortic lesions.
Circulating heat shock protein 27 as a novel marker of subclinical atherosclerosis in type 2 diabetes: a cross-sectional community-based study.
Circulating heat shock protein 60 is associated with early cardiovascular disease.
Circulating heat shock protein and heat shock protein antibody levels in established hypertension.
Co-expression of ICAM-1, VCAM-1, ELAM-1 and Hsp60 in human arterial and venous endothelial cells in response to cytokines and oxidized low-density lipoproteins.
Cooling the Fire of Atherosclerosis with Heat Shock Protein 27.
Cross-reactive B-cell epitopes of microbial and human heat shock protein 60/65 in atherosclerosis.
Cross-reactivity of GroEL antibodies with human heat shock protein 60 and quantification of pathogens in atherosclerosis.
Detection of HSP60 on the membrane surface of stressed human endothelial cells by atomic force and confocal microscopy.
Diet-induced elevation of circulating HSP70 may trigger cell adhesion and promote the development of atherosclerosis in rats.
Differential distribution of 70-kD heat shock protein in atherosclerosis. Its potential role in arterial SMC survival.
Differentially expressed soluble proteins in aortic cells from atherosclerosis-susceptible and resistant pigeons.
Does Hsp60 Provide a Link between Mitochondrial Stress and Inflammation in Diabetes Mellitus?
Down-regulation of hsa-miR-148b inhibits vascular smooth muscle cells proliferation and migration by directly targeting HSP90 in atherosclerosis.
Effect of dyslipidemia on intima-media thickness of intra- and extracranial atherosclerosis by regulating the expression of hsp70 in rabbits.
Effect of hyperglycemia and hyperlipidemia on atherosclerosis in LDL receptor-deficient mice: establishment of a combined model and association with heat shock protein 65 immunity.
Effects of oral and subcutaneous administration of HSP60 on myeloid-derived suppressor cells and atherosclerosis in ApoE-/- mice.
Endothelial cytotoxicity mediated by serum antibodies to heat shock proteins of Escherichia coli and Chlamydia pneumoniae: immune reactions to heat shock proteins as a possible link between infection and atherosclerosis.
Endothelial TNF-? induction by Hsp60 secreted from THP-1 monocytes exposed to hyperglycaemic conditions.
Engineered atherosclerosis-specific zinc ferrite nanocomplex-based MRI contrast agents.
Epitope mapping of Porphyromonas gingivalis heat-shock protein and human heat-shock protein in human atherosclerosis.
Establishment of nasal tolerance to heat shock protein-60 alleviates atherosclerosis by inducing TGF-?-dependent regulatory T cells.
Expression levels of heat shock protein 60 in human endothelial cells in vitro are unaffected by exposure to 50 Hz magnetic fields.
Expression of heat shock protein-70 by dendritic cells in the arterial intima and its potential significance in atherogenesis.
Extracellular HSP27 acts as a signaling molecule to activate NF-?B in macrophages.
Extracellular release of the atheroprotective heat shock protein 27 is mediated by estrogen and competitively inhibits acLDL binding to scavenger receptor-A.
Fusobacterium nucleatum GroEL induces risk factors of atherosclerosis in human microvascular endothelial cells and ApoE(-/-) mice.
Genetic variations of HSPA1A, the heat shock protein levels, and risk of atherosclerosis.
GroEL1, a Heat Shock Protein 60 of Chlamydia pneumoniae, Induces Lectin-Like Oxidized Low-Density Lipoprotein Receptor 1 Expression in Endothelial Cells and Enhances Atherogenesis in Hypercholesterolemic Rabbits.
Heat Shock Protein 27 Protects Against Atherogenesis via an Estrogen-Dependent Mechanism. Role of Selective Estrogen Receptor Beta Modulation.
Heat shock protein 27-derived atheroprotection involves reverse cholesterol transport that is dependent on GM-CSF to maintain ABCA1 and ABCG1 expression in ApoE
Heat shock protein 60 and immune inflammatory responses in atherosclerosis.
Heat Shock Protein 60 in Cardiovascular Physiology and Diseases.
Heat shock protein 60 involvement in vascular smooth muscle cell proliferation.
Heat shock protein 60 is a high-affinity high-density lipoprotein binding protein.
Heat shock protein 60 stimulates the migration of vascular smooth muscle cells via Toll-like receptor 4 and ERK MAPK activation.
Heat shock protein 60/65, beta 2-glycoprotein I and oxidized LDL as players in murine atherosclerosis.
Heat shock protein 65 promotes atherosclerosis through impairing the properties of high density lipoprotein.
Heat shock protein 70 accelerates atherosclerosis by downregulating the expression of ABCA1 and ABCG1 through the JNK/Elk-1 pathway.
Heat shock protein 70 and antibodies to heat shock protein 60 are associated with cerebrovascular atherosclerosis.
Heat shock protein 90 inhibitors attenuate inflammatory responses in atherosclerosis.
Heat Shock Proteins: Mediators of Atherosclerotic Development.
Heat-shock protein 90: A novel autoantigen in human carotid atherosclerosis.
Helicobacter pylori and cardiovascular complications: a mechanism based review on role of Helicobacter pylori in cardiovascular diseases.
Helicobacter pylori and cardiovascular disease: update 2019.
Hemolymph transcriptome analysis of Chinese mitten crab (Eriocheir sinensis) with intact, left cheliped autotomy and bilateral eyestalk ablation.
High dietary methionine plus cholesterol stimulates early atherosclerosis and late fibrous cap development which is associated with a decrease in GRP78 positive plaque cells.
Hormone replacement therapy increases levels of antibodies against heat shock protein 65 and certain species of oxidized low density lipoprotein.
HSP27 Inhibits Homocysteine-Induced Endothelial Apoptosis by Modulation of ROS Production and Mitochondrial Caspase-Dependent Apoptotic Pathway.
Hsp27 promotes ABCA1 expression and cholesterol efflux through the PI3K/PKC?/Sp1 pathway in THP-1 macrophages.
Hsp90 and caveolin are key targets for the proangiogenic nitric oxide-mediated effects of statins.
HSP90 inhibition by 17-DMAG attenuates oxidative stress in experimental atherosclerosis.
HSP90 inhibition suppresses inflammatory response and reduces carotid atherosclerotic plaque formation in ApoE mice.
HSP90 inhibitors as a future therapeutic strategy in diabetes-driven atherosclerosis.
Humoral immune response to heat shock protein 60 of Aggregatibacter actinomycetemcomitans and cross-reactivity with malondialdehyde acetaldehyde-modified LDL.
Identification by a differential proteomic approach of heat shock protein 27 as a potential marker of atherosclerosis.
Identification of atherosclerosis-associated conformational heat shock protein 60 epitopes by phage display and structural alignment.
Identification of immunoreactive epitopes of the Porphyromonas gingivalis heat shock protein in periodontitis and atherosclerosis.
Identification of mono- or poly-specific monoclonal antibody to Porphyromonas gingivalis heat-shock protein 60.
Immune regulation by oral tolerance induces alternate activation of macrophages and reduces markers of plaque destabilization in Apob(tm2Sgy)/Ldlr(tm1Her/J) mice.
Immune responses to heat shock protein in Porphyromonas gingivalis-infected periodontitis and atherosclerosis patients.
Immunization of low-density lipoprotein receptor deficient (LDL-RD) mice with heat shock protein 65 (HSP-65) promotes early atherosclerosis.
Immunization with a combination of ApoB and HSP60 epitopes significantly reduces early atherosclerotic lesion in Apobtm2SgyLdlrtm1Her/J mice.
Immunologic response enhances atherosclerosis-type 1 helper T cell (Th1)-to-type 2 helper T cell (Th2) shift and calcified atherosclerosis in Bacillus Calmette-Guerin (BCG)-treated apolipoprotein E-knockout (apo E-/-) mice.
Immunology of atherosclerosis. Demonstration of heat shock protein 60 expression and T lymphocytes bearing alpha/beta or gamma/delta receptor in human atherosclerotic lesions.
Immunopathogenic consequences of Chlamydia trachomatis 60 kDa heat shock protein expression in the female reproductive tract.
Impact of seropositivity to Chlamydia pneumoniae and anti-hHSP60 on cardiovascular events in hemodialysis patients.
Impairment of vascular function following BCG immunisation is associated with immune responses to HSP-60 in the cholesterol-fed rabbit.
Implications of antibodies to heat-shock proteins in ischemic heart disease.
Increased expression of HDJ-2 (hsp40) in carotid artery atherosclerosis: a novel heat shock protein associated with luminal stenosis and plaque ulceration.
Increased serum levels of heat shock protein 70 are associated with low risk of coronary artery disease.
Induction of Dendritic Cell-Mediated Activation of T Cells From Atherosclerotic Plaques by Human Heat Shock Protein 60.
Induction of dendritic cell-mediated T-cell activation by modified but not native low-density lipoprotein in humans and inhibition by annexin a5: involvement of heat shock proteins.
Induction of heat shock protein in monocytic cells by oxidized low density lipoprotein.
Induction of oral tolerance as treatment or prevention of chronic diseases associated with Chlamydia pneumoniae infection--hypothesis.
Induction of oral tolerance to HSP60 or an HSP60-peptide activates T cell regulation and reduces atherosclerosis.
Infections, heat shock proteins, and atherosclerosis.
Inflammation, heat shock proteins and periodontal pathogens in atherosclerosis: an immunohistologic study.
Interaction of antibodies against cytomegalovirus with heat-shock protein 60 in pathogenesis of atherosclerosis.
Interplay between HSP90 and Nrf2 pathways in diabetes-associated atherosclerosis.
Intranasal immunization with heat shock protein 60 induces CD4(+) CD25(+) GARP(+) and type 1 regulatory T cells and inhibits early atherosclerosis.
Low-Density Lipoproteins Induce Heat Shock Protein 27 Dephosphorylation, Oligomerization, and Subcellular Relocalization in Human Vascular Smooth Muscle Cells.
MicroRNA-23a suppresses the apoptosis of inflammatory macrophages and foam cells in atherogenesis by targeting HSP90.
Modulation of endothelial cell damages by anti-Hsp60 autoantibodies in systemic autoimmune diseases.
Modulation of estrogen signaling by the novel interaction of heat shock protein 27, a biomarker for atherosclerosis, and estrogen receptor beta: mechanistic insight into the vascular effects of estrogens.
Mucosal Tolerance to a Combination of ApoB and HSP60 Peptides Controls Plaque Progression and Stabilizes Vulnerable Plaque in Apob(tm2Sgy)Ldlr(tm1Her)/J Mice.
Mycobacterial heat shock protein 65 (mbHSP65)-induced atherosclerosis: Preventive oral tolerization and definition of atheroprotective and atherogenic mbHSP65 peptides.
Myocardial injury leads to a release of heat shock protein (hsp) 60 and a suppression of the anti-hsp65 immune response.
Nasal immunization with heat shock protein 65 attenuates atherosclerosis and reduces serum lipids in cholesterol-fed wild-type rabbits probably through different mechanisms.
Natural Monoclonal Antibody to Oxidized Low-Density Lipoprotein and Aggregatibacter actinomycetemcomitans.
Non-Toxic Cadmium Concentrations Induce Vascular Inflammation and Promote Atherosclerosis.
Oral administration of Lactococcus lactis delivered heat shock protein 65 attenuates atherosclerosis in low-density lipoprotein receptor-deficient mice.
Oral tolerance with heat shock protein 65 attenuates Mycobacterium tuberculosis-induced and high-fat-diet-driven atherosclerotic lesions.
Oral Tolerization with Mycobacterial Heat Shock Protein 65 Reduces Chronic Experimental Atherosclerosis in Aged Mice.
Peptide 19 of Porphyromonas gingivalis Heat Shock Protein Is a Potent Inducer of Low-Density Lipoprotein Oxidation.
Pharmacological attenuation of apoptosis in reoxygenated endothelial cells.
Porphyromonas gingivalis HSP60 peptides have distinct roles in the development of atherosclerosis.
Predominant immunoreactivity of Porphyromonas gingivalis heat shock protein in autoimmune diseases.
Prognostic value of antibody titre to heat-shock protein 65 on cardiovascular events.
Promotion of atherosclerosis in high cholesterol diet-fed rabbits by immunization with the P277 peptide.
Regulation of tissue factor--mediated initiation of the coagulation cascade by cell surface grp78.
Relationship between periodontal infections and systemic disease.
Relationship between plasma cholesterol, von Willebrand factor concentrations, extent of atherosclerosis and antibody titres to heat shock proteins-60, -65 and -70 in cholesterol-fed rabbits.
Role of heat shock protein 22 in the protective effect of geranylgeranylacetone in response to oxidized-LDL.
Role of Heat Shock Protein 27 in Modulating Atherosclerotic Inflammation.
Role of heat shock protein 65/60 in the pathogenesis of atherosclerosis.
Serum Heat Shock Protein 27 Levels Represent a Potential Therapeutic Target for Atherosclerosis: Observations From a Human Cohort and Treatment of Female Mice.
Serum heat shock protein 70 levels predict the development of atherosclerosis in subjects with established hypertension.
Social Determinants and Heat Shock Protein-70 Among African American and Non-Hispanic White Women With Atherosclerosis: A Pilot Study.
Soy isoflavones reduce heat shock proteins in experimental atherosclerosis.
Staining of endothelial cells and macrophages in atherosclerotic lesions with human heat-shock protein-reactive antisera.
Stressing the obvious? Cell stress and cell stress proteins in cardiovascular disease.
Subcutaneous immunization with heat shock protein-65 reduces atherosclerosis in Apoe(-/-) mice.
Sublingual Vaccine with GroEL Attenuates Atherosclerosis.
T-cell clonality to Porphyromonas gingivalis and human heat shock protein 60s in patients with atherosclerosis and periodontitis.
T-cell reactivity against HSP60 relates to early but not advanced atherosclerosis.
Targeting HSP90 Ameliorates Nephropathy and Atherosclerosis Through Suppression of NF-?B and STAT Signaling Pathways in Diabetic Mice.
Temporal expression of heat shock proteins 60 and 70 at lesion-prone sites during atherogenesis in ApoE-deficient mice.
The GroEL protein of Porphyromonas gingivalis regulates atherogenic phenomena in endothelial cells mediated by upregulating toll-like receptor 4 expression.
The Heat Shock Protein 27 Immune Complex Enhances Exosomal Cholesterol Efflux.
The interaction and cellular localization of HSP27 and ERbeta are modulated by 17beta-estradiol and HSP27 phosphorylation.
The relationship between HSP60 gene polymorphisms and susceptibility to atherosclerosis.
The role of (auto-) immunity in atherogenesis.
The role of heat shock protein (HSP) in atherosclerosis: Pathophysiology and clinical opportunities.
The role of heat shock protein 90 in migration and proliferation of vascular smooth muscle cells in the development of atherosclerosis.
The role of heat shock proteins in atherosclerosis.
Tolerization against atherosclerosis using heat shock protein 60.
Trimethylamine-N-oxide, as a risk factor for atherosclerosis, induces stress in J774A.1 murine macrophages.
[Chronic bacterial infection as a risk factor for atherogenesis. The role of heat shock protein]
[Recent progress in the development of atherosclerosis: role of heat shock protein].
Atrial Fibrillation
Association of high intracellular, but not serum, heat shock protein 70 with postoperative atrial fibrillation.
Association of Met439Thr Substitution in Heat Shock Protein 70 Gene with Postoperative Atrial Fibrillation and Serum HSP70 Protein Levels.
Atrial heat shock protein levels are associated with early postoperative and persistence of atrial fibrillation.
Decreased Cardiac Expression of Heat Shock Protein 27 is Associated with Atrial Fibrillation in Patients with Rheumatic Heart Disease.
Effects of a heat shock protein inducer on the atrial fibrillation substrate caused by acute atrial ischaemia.
Electrophysiological Correlation and Prognostic Impact of Heat Shock Protein 27 in Atrial Fibrillation.
Evaluating Serum Heat Shock Protein Levels as Novel Biomarkers for Atrial Fibrillation.
Expression of mortalin in patients with chronic atrial fibrillation.
Genome-wide association study of myocardial infarction, atrial fibrillation, acute stroke, acute kidney injury and delirium after cardiac surgery - a sub-analysis of the RIPHeart-Study.
HALT & REVERSE: Hsf1 activators lower cardiomyocyt damage; towards a novel approach to REVERSE atrial fibrillation.
Heat Shock Protein 70 Is Associated With Cardioversion Outcome and Recurrence of Symptomatic Recent Onset Atrial Fibrillation in Hypertensive Patients.
Heat shock protein as a mediator between the effects of corticosteroids on atrial fibrillation recurrence after catheter ablation.
Heat shock protein inducer GGA*-59 reverses contractile and structural remodeling via restoration of the microtubule network in experimental Atrial Fibrillation.
Heat shock protein inducer modifies arrhythmogenic substrate and inhibits atrial fibrillation in the failing heart.
Heat shock protein upregulation protects against pacing-induced myolysis in HL-1 atrial myocytes and in human atrial fibrillation.
HSPB1, HSPB6, HSPB7 and HSPB8 protect against RhoA GTPase-induced remodeling in tachypaced atrial myocytes.
Intracellular heat shock protein 70: a possible therapeutic target for preventing postoperative atrial fibrillation.
Low preoperative HSP70 atrial myocardial levels correlate significantly with high incidence of postoperative atrial fibrillation after cardiac surgery.
Overexpression of heat shock protein 60/10 in myocardium of patients with chronic atrial fibrillation.
Response of circulating heat shock protein 70 and anti-heat shock protein 70 antibodies to catheter ablation of atrial fibrillation.
Screening of novel HSP-inducing compounds to conserve cardiomyocyte function in experimental atrial fibrillation.
The expression of heat shock protein 60 in myocardium of patients with chronic atrial fibrillation.
The protective effect of heat shock protein 70 (Hsp70) in atrial fibrillation in various cardiomyopathy conditions.
Unchanged heat-shock protein 70 expression in myocardium of patients with permanent atrial fibrillation.
Autoimmune Diseases
Aberrant expression and secretion of heat shock protein 90 in patients with bullous pemphigoid.
Activation of benign autoimmunity as both tumor and autoimmune disease immunotherapy: A comprehensive review.
Activation of T cells recognizing self 60-kD heat shock protein can protect against experimental arthritis.
Aminoacyl-tRNA Synthetase-Interacting Multifunctional Protein 1/p43 Controls Endoplasmic Reticulum Retention of Heat Shock Protein gp96. Its Pathological Implications in Lupus-Like Autoimmune Diseases.
Aminoacyl-tRNA synthetase-interacting multifunctional protein 1/p43 controls endoplasmic reticulum retention of heat shock protein gp96: its pathological implications in lupus-like autoimmune diseases.
Anti-HSP auto-antibodies enhance HSP-induced pro-inflammatory cytokine production in human monocytic cells via Toll-like receptors.
Antibodies to human HSP60 in patients with juvenile chronic arthritis, diabetes mellitus, and cystic fibrosis.
Antibody reactivity to mycobacterial 65 kDa heat shock protein: relevance to autoimmunity.
Autoantibodies against chaperonin CCT in human sera with rheumatic autoimmune diseases: comparison with antibodies against other Hsp60 family proteins.
Autolytic Mycobacterium leprae Hsp65 fragments may act as biological markers for autoimmune diseases.
Cell surface expression of an endoplasmic reticulum resident heat shock protein gp96 triggers MyD88-dependent systemic autoimmune diseases.
Chaperonin-Co-chaperonin Interactions.
Chaperonopathies and Chaperonotherapy. Hsp60 as Therapeutic Target in Cancer: Potential Benefits and Risks.
Characterization and expression of SpHsp60 in hemocytes after challenge to bacterial, osmotic and thermal stress from the mud crab Scylla paramamosain.
Cloning and nucleotide sequence comparison of the groE operon of Pseudomonas aeruginosa and Burkholderia cepacia.
Constitutive expression of a groEL-related protein on the surface of human gamma/delta cells.
Cross-reactive mycobacterial and self hsp60 epitope recognition in I-A(g7) expressing NOD, NOD-asp and Biozzi AB/H mice.
Deletion of CD24 impairs development of heat shock protein gp96-driven autoimmune disease through expansion of myeloid-derived suppressor cells.
Detection of autoantibodies to the 90 kDa heat shock protein in systemic lupus erythematosus and other autoimmune diseases.
Development of IgG responses to mycobacterial antigens.
DNA vaccine containing the mycobacterial hsp65 gene prevented insulitis in MLD-STZ diabetes.
EC144, a synthetic inhibitor of heat shock protein 90, blocks innate and adaptive immune responses in models of inflammation and autoimmunity.
Elevated blood Hsp60, its structural similarities and cross-reactivity with thyroid molecules, and its presence on the plasma membrane of oncocytes point to the chaperonin as an immunopathogenic factor in Hashimoto's thyroiditis.
Elevation of IL-6 in transgenic mice results in increased levels of the 90 kDa heat shock protein (hsp90) and the production of anti-hsp90 antibodies.
Elongated Flexuous Plant Virus-Derived Nanoparticles Functionalized for Autoantibody Detection.
Expression of the human heat shock protein 60 in thyroid, pancreatic, hepatic and adrenal autoimmunity.
Genes encoding three new members of the leukocyte antigen 6 superfamily and a novel member of Ig superfamily, together with genes encoding the regulatory nuclear chloride ion channel protein (hRNCC) and an N omega-N omega-dimethylarginine dimethylaminohydrolase homologue, are found in a 30-kb segment of the MHC class III region.
Heat shock protein 60 mRNA is not increased in Graves' disease thyroid tissue.
Heat shock protein 90 associates with Toll-like receptors 7/9 and mediates self-nucleic acid recognition in SLE.
Heat shock protein 90 inhibition: A potential double- or triple-edged sword in the treatment of mucous membrane pemphigoid.
Heat shock protein 90 is critical for regulation of phenotype and functional activity of human T lymphocytes and NK cells.
Heat shock protein and gliadin peptide promote development of peptidase antibodies in children with autism and patients with autoimmune disease.
Heat shock protein bystander antigens for peptide immunotherapy in autoimmune disease.
Heat shock protein reactivity of lymphocytes isolated from heterotopic rat cardiac allografts.
Heat shock proteins and allograft rejection.
Heat shock proteins in health and disease: therapeutic targets or therapeutic agents?
Helicobacter pylori infection in connective tissue disorders is associated with high levels of antibodies to mycobacterial hsp65 but not to human hsp60.
Highly autoproliferative T cells specific for 60-kDa heat shock protein produce IL-4/IL-10 and IFN-gamma and are protective in adjuvant arthritis.
HSP60 as a drug target.
HSP60: issues and insights on its therapeutic use as an immunoregulatory agent.
HSP70-1 promoter region polymorphism tested in three autoimmune diseases.
HSP70i accelerates depigmentation in a mouse model of autoimmune vitiligo.
Hsp90 and its co-chaperone, Sgt1, as autoantigens in dilated cardiomyopathy.
Hsp90 blockade modulates bullous pemphigoid IgG-induced IL-8 production by keratinocytes.
Human Hsp60: bacterial expression, purification, development of monoclonal antibodies and a sandwich ELISA for quantitation.
Identification of a 40-kDa human protein that cross-reacts with prokaryotic hsp60/chaperonins.
Identification of human heat shock protein 60 (Hsp60) and anti-Hsp60 antibodies in the peripheral circulation of normal individuals.
Immune modulation induced by tuberculosis DNA vaccine protects non-obese diabetic mice from diabetes progression.
Immune recognition of human Hsp60 by Lyme disease patient sera.
Immune responses to heat shock protein in Porphyromonas gingivalis-infected periodontitis and atherosclerosis patients.
Immune responses to Mycobacterial heat shock protein 70 accompany self-reactivity to human BiP in rheumatoid arthritis.
Immune tolerance therapies for autoimmune diseases based on heat shock protein T-cell epitopes.
Immunomodulation and protection induced by DNA-hsp65 vaccination in an animal model of arthritis.
Immunomodulatory effects of heat shock protein 90 inhibition on humoral immune responses.
Induction of endothelial cell apoptosis by the binding of anti-endothelial cell antibodies to Hsp60 in vasculitis-associated systemic autoimmune diseases.
Infection, autoimmunity and autoimmune disease.
Inhibition of adjuvant arthritis by a DNA vaccine encoding human heat shock protein 60.
Inhibitory effects of heat shock protein 90 blockade on proinflammatory human Th1 and Th17 cell subpopulations.
Interferon gamma and iodide increase the inducibility of the 72 kD heat shock protein in cultured human thyroid epithelial cells.
Lactoferrin triggers in vitro proliferation of T cells of Lewis rats submitted to mycobacteria-induced adjuvant arthritis.
Low levels of heat shock proteins-60 and -65 autoantibodies in Sjögren's syndrome.
Modulation of pristane-induced arthritis by mycobacterial antigens.
Molecular cloning, characterization and expression patterns of HSP60 in the grass carp (Ctenopharyngodon idella).
Mucosal expression by B7-positive cells of the 60-kilodalton heat-shock protein in inflammatory bowel disease.
Mycobacterial and mouse HSP70 have immuno-modulatory effects on dendritic cells.
Oral administration of HSP-containing E. coli extract OM-89 has suppressive effects in autoimmunity. Regulation of autoimmune processes by modulating peripheral immunity towards hsp's?
Pep19 drives epitope spreading in periodontitis and periodontitis-associated autoimmune diseases.
Predominant immunoreactivity of Porphyromonas gingivalis heat shock protein in autoimmune diseases.
Prevention of autoimmune lysis by T cells with specificity for a heat shock protein by antisense oligonucleotide treatment.
Proposing BCG Vaccination for Mycobacterium avium ss. paratuberculosis (MAP) Associated Autoimmune Diseases.
Recognition of heat shock protein 60 epitopes in children with type 1 diabetes.
Robust immunoreactivity of teenager sera against peptide 19 from Porphyromonas gingivalis HSP60.
Role of hsp90 in systemic lupus erythematosus and its clinical relevance.
Sequence homologies between hsp60 and autoantigens.
Serum antibody response to group II chaperonin from Methanobrevibacter oralis and human chaperonin CCT.
Serum heat shock protein 60 can predict remission of flare-up in juvenile idiopathic arthritis.
Specific regulation of HSPs in human tumor cell lines by PSK.
Susceptibility to pristane-induced arthritis is altered with changes in bowel flora.
Takayasu's arteritis: role of Mycobacterium tuberculosis and its 65 kDa heat shock protein.
Targeted mutation of the mouse Grp94 gene disrupts development and perturbs endoplasmic reticulum stress signaling.
The 8.5-kb PstI allele of the stress protein gene, Hsp70-2: an independent risk factor for systemic lupus erythematosus in African Americans?
The heat-shock protein 90 inhibitor 17-allylamino-17-demethoxygeldanamycin suppresses glial inflammatory responses and ameliorates experimental autoimmune encephalomyelitis.
The immune response to mycobacterial heat shock proteins.
Topically Applied Hsp90 Blocker 17AAG Inhibits Autoantibody-Mediated Blister-Inducing Cutaneous Inflammation.
What is the evidence that mycobacteria are associated with the pathogenesis of Sjogren's syndrome?
[Autoimmune diseases and stress proteins]
[Clinical immunology of tuberculosis]
[Detection of humoral immune response to inner ear proteins in patients with sensorineural hearing loss]
[Induction of mucosal immunity to mycobacterial heat shock protein (hsp) 65 by colonic inoculation of plasmid DNA encoding hsp65]
Axial Spondyloarthritis
IgG subclass antibodies to human and bacterial HSP60 are not associated with disease activity and progression over time in axial spondyloarthritis.
Plasma heat shock protein 90 levels in patients with spondyloarthritis and their relation to structural changes: a cross-sectional study.
Babesiosis
Expression analysis of heat shock protein 20 and rhoptry-associated protein 1a in sexual stages and kinetes of Babesia bigemina.
Bacteremia
Comparative Exoproteomics and Host Inflammatory Response in Staphylococcus aureus Skin and Soft Tissue Infections, Bacteremia, and Subclinical Colonization.
Bacterial Infections
Anti-60-kDa heat shock protein antibodies in fetal serum: a biomarker for unexplained small for gestational age fetuses.
Association between antibodies to heat shock protein 65 and coronary atherosclerosis. Possible mechanism of action of Helicobacter pylori and other bacterial infections in increasing cardiovascular risk.
Bacterial infection elicits heat shock protein 72 release from pleural mesothelial cells.
Cloning and identification of grass carp transcription factor HSF1 and its characterization involving the production of fish HSP70.
Cloning, molecular characterization and expression analysis of heat shock cognate 70 (Hsc70) cDNA from turbot (Scophthalmus maximus).
Cross-reactive B-cell epitopes of microbial and human heat shock protein 60/65 in atherosclerosis.
Expression analysis of heat shock protein genes during Aeromonas hydrophila infection in rohu, Labeo rohita, with special reference to molecular characterization of Grp78.
Genome-wide identification of hsp40 genes in channel catfish and their regulated expression after bacterial infection.
Heat shock protein 70 from Litopenaeus vannamei (LvHSP70) is involved in the innate immune response against white spot syndrome virus (WSSV) infection.
Heat shock protein 90: its inhibition and function.
Heat shock protein profiles on the protein and gene expression levels in olive flounder kidney infected with Streptococcus parauberis.
Heat shock proteins form part of a danger signal cascade in response to lipopolysaccharide and GroEL.
Heat shock proteins protect platyfish (Xiphophorus maculatus) from Yersinia ruckeri induced mortality.
Hsp90, Hsp60 and sHsp families of heat shock protein genes in channel catfish and their expression after bacterial infections.
Identification of atherosclerosis-associated conformational heat shock protein 60 epitopes by phage display and structural alignment.
Increased levels of IgG antibodies against human HSP60 in patients with spondyloarthritis.
Multiplex immune-related genes expression analysis response to bacterial challenge in mud crab, Scylla paramamosain.
Significance of serum antibodies against HSP 60 and HSP 70 for the diagnostic of infectious diseases.
Synergistic and differential modulation of immune responses by Hsp60 and lipopolysaccharide.
Understanding GroEL and DnaK Stress Response Proteins as Antigens for Bacterial Diseases.
[Chronic bacterial infection as a risk factor for atherogenesis. The role of heat shock protein]
[Modification of the immune system by heat shock protein induced by bacterial infection]
[Participation of heat shock proteins in modulation of NF-?B transcription factor activation during bacterial infections].
Barrett Esophagus
Discovery of a Novel Connecting Link between Renin-Angiotensin System and Cancer in Barrett's Esophagus by Proteomic Screening.
Bartonella Infections
Detection of Bartonella henselae DNA in clinical samples including peripheral blood of immune competent and immune compromised patients by three nested amplifications.
Detection of Bartonella species from ticks, mites and small mammals in Korea.
Behcet Syndrome
Aberrant Activation of Heat Shock Protein 60/65 Reactive T Cells in Patients with Behcet's Disease.
Bioinformatics-Driven New Immune Target Discovery in Disease.
Characterization of T cells specific for an epitope of human 60-kD heat shock protein (hsp) in patients with Behcet's disease (BD) in Japan.
Involvement of Th1 cells and heat shock protein 60 in the pathogenesis of intestinal Behcet's disease.
Oral tolerization with peptide 336-351 linked to cholera toxin B subunit in preventing relapses of uveitis in Behcet's disease.
The role of heat shock protein 60, vascular endothelial growth factor and antiphospholipid antibodies in Behçet disease.
beta-Thalassemia
Effect of zinc supplementation on serum antibody titers to heat shock protein 27 in patients with thalassemia major.
Increased Serum Heat Shock Protein 27 Antibody Titers and Prooxidant-Antioxidant Balance in Patients with Beta-Thalassemia Major.
Biliary Atresia
Analysis of Biliary Epithelial-Mesenchymal Transition in Portal Tract Fibrogenesis in Biliary Atresia.
Elevated serum heat shock protein 70 and liver stiffness reflect hepatic dysfunction and severity in postoperative biliary atresia.
Identification of HSP90 as potential biomarker of biliary atresia using two-dimensional electrophoresis and mass spectrometry.
Blast Crisis
Combination of the histone deacetylase inhibitor LBH589 and the hsp90 inhibitor 17-AAG is highly active against human CML-BC cells and AML cells with activating mutation of FLT-3.
Blindness
Epigenetic silencing of heat shock protein 70 through DNA hypermethylation in pseudoexfoliation syndrome and glaucoma.
Blister
Heat shock protein 47 is up-regulated in conjunctival bleb scarring after filtration surgery in rats.
Heat shock protein 90 inhibition: A potential double- or triple-edged sword in the treatment of mucous membrane pemphigoid.
Heat shock protein 90: a pathophysiological factor and novel treatment target in autoimmune bullous skin diseases.
Heat-shock protein 60 translocates to the surface of apoptotic cells and differentiated megakaryocytes and stimulates phagocytosis.
Molecular chaperones are targets of autoimmunity in Ro(SS-A) immune mice.
Serial Changes of Heat Shock Protein 70 and Interleukin-8 in Burn Blister Fluid.
Bluetongue
Hsp90 chaperones Bluetongue virus proteins and prevents proteasomal degradation.
Bone Diseases, Metabolic
Heat shock protein 60 protects skeletal tissue against glucocorticoid-induced bone mass loss by regulating osteoblast survival.
Inhibitors of heat shock protein 90 augment endothelin?1?induced heat shock protein 27 through the SAPK/JNK signaling pathway in osteoblasts.
Bone Resorption
Characterization of a natural mouse monoclonal antibody recognizing epitopes shared by oxidized low-density lipoprotein and chaperonin 60 of Aggregatibacter actinomycetemcomitans.
Heat shock protein 60 causes osteoclastic bone resorption via toll-like receptor-2 in estrogen deficiency.
Homogeneous Escherichia coli chaperonin 60 induces IL-1 beta and IL-6 gene expression in human monocytes by a mechanism independent of protein conformation.
Increased circulating heat shock protein 60 induced by menopause, stimulates apoptosis of osteoblast-lineage cells via up-regulation of toll-like receptors.
Molecular chaperones stimulate bone resorption.
Natural Monoclonal Antibody to Oxidized Low-Density Lipoprotein and Aggregatibacter actinomycetemcomitans.
Porphyromonas gingivalis GroEL induces osteoclastogenesis of periodontal ligament cells and enhances alveolar bone resorption in rats.
Spondyloarthropathies and bone resorption: a possible role of heat shock protein (Hsp70).
Tannerella forsythia GroEL induces inflammatory bone resorption and synergizes with interleukin-17.
The potent bone-resorbing mediator of Actinobacillus actinomycetemcomitans is homologous to the molecular chaperone GroEL.
The virulence factor GroEL promotes gelatinase secretion from cells in the osteoblast lineage: Implication for direct crosstalk between bacteria and adult cells.
Borna Disease
Heat shock cognate protein 70 controls Borna disease virus replication via interaction with the viral non-structural protein X.
Molecular chaperone BiP interacts with Borna disease virus glycoprotein at cell surface.
Bradycardia
Potentiation of baroreceptor reflex response by heat shock protein 70 in nucleus tractus solitarii confers cardiovascular protection during heatstroke.
Brain Abscess
Nestin and small heat shock protein expression on reactive astrocytes and endothelial cells in cerebral abscess.
Brain Concussion
[Changes of HSP70, bFGF and TGF-beta1 expression in rat brain after concussion]
Brain Death
Brain death induces renal expression of heme oxygenase-1 and heat shock protein 70.
Direct peritoneal resuscitation reduces intestinal permeability after brain death.
Renal expression of heat shock proteins after brain death induction in rats.
Brain Diseases
A designer molecular chaperone against transmissible spongiform encephalopathy slows disease progression in mice and macaques.
A molecular chaperone for mitochondrial complex I assembly is mutated in a progressive encephalopathy.
Biallelic Variants in CNPY3, Encoding an Endoplasmic Reticulum Chaperone, Cause Early-Onset Epileptic Encephalopathy.
Druggability of Mortalin for Cancer and Neuro-Degenerative Disorders.
Early diffusion weighted imaging and expression of heat shock protein 70 in newborn pigs with hypoxic ischaemic encephalopathy.
FOXRED1, encoding an FAD-dependent oxidoreductase complex-I-specific molecular chaperone, is mutated in infantile-onset mitochondrial encephalopathy.
Geldanamycin treatment during cerebral ischemia/reperfusion attenuates p44/42 mitogen-activated protein kinase activation and tissue damage.
Molecular chaperone treats encephalopathy.
Novel interactions of GRP78: UPR and estrogen responses in the brain.
Opportunities and Challenges for Molecular Chaperone Modulation to Treat Protein-Conformational Brain Diseases.
Pallido-nigral spheroids in nonhuman primates: accumulation of heat shock proteins in astroglial processes.
Stress protein inclusions in cerebral vessels in dialysis encephalopathy.
Stress response in the central nervous system of a transgenic mouse model of bovine spongiform encephalopathy.
Brain Edema
Aging enhances intracerebral hemorrhage-induced brain injury in rats.
Attenuating brain edema, hippocampal oxidative stress, and cognitive dysfunction in rats using hyperbaric oxygen preconditioning during simulated high-altitude exposure.
Neuroprotective effects of 5-HT3 receptor antagonist ondansetron on morphine withdrawal induced brain edema formation, blood-brain barrier dysfunction, neuronal injuries, glial activation and heat shock protein upregulation in the brain.
RACK1 upregulation induces neuroprotection by activating the IRE1-XBP1 signaling pathway following traumatic brain injury in rats.
Role of neurochemicals in brain edema and cell changes following hyperthermic brain injury in the rat.
[Effect of heat shock protein 70 on nuclear factor-KappaB/inhibitor protein-alpha of nuclear factor-KappaB in brain edema induced by infection in rat]
[Effects of Cinnabar and Realgar in Angong Niuhuang powder on heat shock protein, nitric oxide synthase and inflammatory cytokines in contusion cerebral edema]
[Heat shock protein 70 induction by heat stress suppress interleukin-1beta and tumor necrosis factor-alpha levels in the brain tissue in rats with infectious brain edema]
Brain Infarction
Intranasal basic fibroblast growth factor attenuates endoplasmic reticulum stress and brain injury in neonatal hypoxic-ischaemic injury.
Brain Injuries
Antioxidant compounds EGB-761 and BN-520 21 attenuate heat shock protein (HSP 72 kD) response, edema and cell changes following hyperthermic brain injury. An experimental study using immunohistochemistry in the rat.
Calorie restriction and stroke.
Conditioning effects of repetitive mild neurotrauma on motor function in an animal model of focal brain injury.
Decreased S100B serum levels after treatment in bipolar patients in a manic phase.
Dual inhibitory roles of geldanamycin on the c-Jun NH(2)-terminal kinase 3 signal pathway through suppressing the expression of mixed-lineage kinase 3 and attenuating the activation of apoptosis signal-regulating kinase 1 via facilitating the activation of Akt in ischemic brain injury.
Effects of 2-Deoxyglucose on ischemic brain injuries in rats.
Endothelium-targeted overexpression of heat shock protein 27 ameliorates blood-brain barrier disruption after ischemic brain injury.
Exercise Preconditioning Attenuates Neurological Injury by Preserving Old and Newly Formed HSP72-Containing Neurons in Focal Brain Ischemia Rats.
Expression of brain-derived neurotrophic factor, nerve growth factor, and heat shock protein HSP70 following fluid percussion brain injury in rats.
Expression of heat shock protein after +Gz exposure and its protective effects on +Gz-induced brain injury.
Geldanamycin inhibits Fas signaling pathway and protects neurons against ischemia.
Geldanamycin reduced brain injury in mouse model of intracerebral hemorrhage.
Heat shock protein 22 modulates NRF1/TFAM-dependent mitochondrial biogenesis and DRP1-sparked mitochondrial apoptosis through AMPK-PGC1? signaling pathway to alleviate the early brain injury of subarachnoid hemorrhage in rats.
Heat Shock Protein 70 (HSP70) Induction: Chaperonotherapy for Neuroprotection after Brain Injury.
Heat shock protein 70 expression in epilepsy suggests stress rather than protection.
Heat shock protein 70 upregulation by geldanamycin reduces brain injury in a mouse model of intracerebral hemorrhage.
Heat shock protein modulation of KATP and KCa channel cerebrovasodilation after brain injury.
Heat-shock protein 72 expression in excitotoxic versus penetrating injuries of the rodent cerebral cortex.
Hypothermia decreases excitatory neurotransmitter release in bacterial meningitis in rabbits.
Immunolocalization of heat shock protein after fluid percussive brain injury and relationship to breakdown of the blood-brain barrier.
Intranasal basic fibroblast growth factor attenuates endoplasmic reticulum stress and brain injury in neonatal hypoxic-ischaemic injury.
Intrathecal heat shock protein 60 mediates neurodegeneration and demyelination in the CNS through a TLR4- and MyD88-dependent pathway.
Neurofilament heavy chain and heat shock protein 70 as markers of seizure-related brain injury.
Neuroprotective Effects of Valproic Acid on Blood-Brain Barrier Disruption and Apoptosis-Related Early Brain Injury in Rats Subjected to Subarachnoid Hemorrhage Are Modulated by Heat Shock Protein 70/Matrix Metalloproteinases and Heat Shock Protein 70/AKT Pathways.
Peripherally misfolded proteins exacerbate ischemic stroke-induced neuroinflammation and brain injury.
Pharmacological induction of the 70-kDa heat shock protein protects against brain injury.
RACK1 upregulation induces neuroprotection by activating the IRE1-XBP1 signaling pathway following traumatic brain injury in rats.
Reactive astrocytes in acute stage after experimental brain injury: relationship to extravasated plasma protein and expression of heat shock protein.
Regulation of inflammatory transcription factors by heat shock protein 70 in primary cultured astrocytes exposed to oxygen-glucose deprivation.
The 70-kDa heat shock protein (Hsp70) as a therapeutic target for stroke.
[Protective effect of prostaglandin E1 against brain injury induced by hyperoxia in neonatal rats].
Brain Injuries, Traumatic
72-kDa heat shock protein and mRNA expression after controlled cortical impact injury with hypoxemia in rats.
?-adrenergic receptor inhibition affects cerebral glucose metabolism, motor performance, and inflammatory response after traumatic brain injury.
Alterations of GABA(A) and glutamate receptor subunits and heat shock protein in rat hippocampus following traumatic brain injury and in posttraumatic epilepsy.
Anesthesia for euthanasia influences mRNA expression in healthy mice and after traumatic brain injury.
Expression of heat shock protein 70 and Annexin A1 in serum of patients with acutely severe traumatic brain injury.
Hyperglycemia and antibody titres against heat shock protein 27 in traumatic brain injury patients on parenteral nutrition.
Immunolocalization of Toll-like receptors 2 and 4 as well as their endogenous ligand, heat shock protein 70, in rat traumatic brain injury.
Induction of the stress response after inflicted and non-inflicted traumatic brain injury in infants and children.
Neuroprotective effects of dexmedetomidine on traumatic brain injury: Involvement of neuronal apoptosis and HSP70 expression.
Optical imaging of cell death in traumatic brain injury using a heat shock protein-90 alkylator.
Patterns of heat-shock protein 70 biosynthesis following human traumatic brain injury.
Regional induction of c-fos and heat shock protein-72 mRNA following fluid-percussion brain injury in the rat.
Subcellular stress response after traumatic brain injury.
Temporal and regional profiles of cytoskeletal protein accumulation in the rat brain following traumatic brain injury.
The 70 kDa heat shock protein protects against experimental traumatic brain injury.
Brain Ischemia
10 kD mitochondrial matrix heat shock protein mRNA is induced following global brain ischemia in the rat.
70-kDa Heat Shock Protein Downregulates Dynamin in Experimental Stroke: A New Therapeutic Target?
A prospective evaluation of the heat shock protein 70 gene polymorphisms and the risk of stroke.
Acceleration of TDP43 and FUS/TLS protein expressions in the preconditioned hippocampus following repeated transient ischemia.
Alpha2 adrenoreceptor agonist regulates protein kinase C-induced heat shock protein 27 phosphorylation in C6 glioma cells.
Angiotensin II AT1 receptor blockade abolishes brain microvascular inflammation and heat shock protein responses in hypertensive rats.
Cellular and Subcellular Localization of Endoplasmic Reticulum Chaperone GRP78 Following Transient Focal Cerebral Ischemia in Rats.
Combined prostaglandin E1 and lithium exert potent neuroprotection in a rat model of cerebral ischemia.
Correlation between changes in apparent diffusion coefficient and induction of heat shock protein, cell-specific injury marker expression, and protein synthesis reduction on diffusion-weighted magnetic resonance images after temporary focal cerebral ischemia in rats.
Different thresholds of HSP70 and HSC70 heat shock mRNA induction in post-ischemic gerbil brain.
Differential cellular distribution and dynamics of HSP70, cyclooxygenase-2, and c-Fos in the rat brain after transient focal ischemia or kainic acid.
Dual inhibitory roles of geldanamycin on the c-Jun NH(2)-terminal kinase 3 signal pathway through suppressing the expression of mixed-lineage kinase 3 and attenuating the activation of apoptosis signal-regulating kinase 1 via facilitating the activation of Akt in ischemic brain injury.
Early 72-kDa heat shock protein induction in microglial cells following focal ischemia in the rat brain.
Effects of exogenous vitamin D on endoplasmic reticulum stress-related factors in the vitamin D deficiency rats with cerebral ischemia.
Effects of global cerebral ischemia and preconditioning on heat shock protein 27 immunocontent and phosphorylation in rat hippocampus.
Effects of heat shock protein 72 (Hsp72) on evolution of astrocyte activation following stroke in the mouse.
Effects of hsp70.1 gene knockout on the mitochondrial apoptotic pathway after focal cerebral ischemia.
Expression of glial fibrillary acidic protein in areas of focal cerebral ischemia accompanies neuronal expression of 72-kDa heat shock protein.
Geldanamycin inhibits Fas signaling pathway and protects neurons against ischemia.
Geranylgeranylacetone protects against cerebral ischemia and reperfusion injury: HSP90 and eNOS phosphorylation involved.
Glutamate receptor antagonists modulate heat shock protein response in focal brain ischemia.
Heat shock protein 72 (Hsp72) improves long term recovery after focal cerebral ischemia in mice.
Heat shock protein 72 inhibits c-Jun N-terminal kinase 3 signaling pathway via Akt1 during cerebral ischemia.
Heat shock protein 72 overexpression protects against hyperthermia, circulatory shock, and cerebral ischemia during heatstroke.
Heat shock protein expression protects against cerebral ischemia and monoamine overload in rat heatstroke.
Heat shock protein signaling in brain ischemia and injury.
Hsp27 protects against ischemic brain injury via attenuation of a novel stress-response cascade upstream of mitochondrial cell death signaling.
HSPA9/Mortalin mediates axo-protection and modulates mitochondrial dynamics in neurons.
Human-derived physiological heat shock protein 27 complex protects brain after focal cerebral ischemia in mice.
Immunohistochemical assessment of constitutive and inducible heat-shock protein 70 and ubiquitin in human cerebellum and caudate nucleus.
Immunohistochemical visualization of heat shock protein-70 in the gerbil hippocampus following repeated brief cerebral ischemia.
Indomethacin attenuates early increases in inducible heat shock protein 70 after cerebral ischemia/reperfusion in piglets
Indomethacin attenuates early increases in inducible heat shock protein 70 after cerebral ischemia/reperfusion in piglets.
Induction of 27-kDa heat shock protein following cerebral ischemia in a rat model of ischemic tolerance.
Induction of 70-kDa heat shock protein and hsp70 mRNA following transient focal cerebral ischemia in the rat.
Induction of c-fos and c-jun gene products and heat shock protein after brief and prolonged cerebral ischemia in gerbils.
Induction of heat shock protein 40 and GrpE mRNAs following transient focal cerebral ischemia in the rat.
Induction of heat shock protein 70 and glial fibrillary acidic protein in the postischemic gerbil hippocampus.
Induction of mitochondrial heat shock protein 60 and 10 mRNAs following transient focal cerebral ischemia in the rat.
Involvement of the dual-specificity phosphatase M3/6 in c-Jun N-terminal kinase inactivation following cerebral ischemia in the rat hippocampus.
Ischemic preconditioning prevents protein aggregation after transient cerebral ischemia.
Ischemic preconditioning protects brain from ischemia/reperfusion injury by attenuating endoplasmic reticulum stress-induced apoptosis through PERK pathway.
Lack of neuroprotection by heat shock protein 70 overexpression in a mouse model of global cerebral ischemia.
miR-181 regulates GRP78 and influences outcome from cerebral ischemia in vitro and in vivo.
Mitochondrial heat shock protein 60 is increased in cerebrospinal fluid following pediatric traumatic brain injury.
Neuroprotection of hypoxic postconditioning against global cerebral ischemia through influencing posttranslational regulations of heat shock protein 27 in adult rats.
Neuroprotective effect of a heat shock protein inducer, geranylgeranylacetone in permanent focal cerebral ischemia.
Neurotherapeutic activity of the recombinant heat shock protein Hsp70 in a model of focal cerebral ischemia in rats.
Overexpression of heat shock protein 27 reduces cortical damage after cerebral ischemia.
Overexpression of rat heat shock protein 70 reduces neuronal injury after transient focal ischemia, transient global ischemia, or kainic acid-induced seizures.
Oxidative stress and ischemic injuries in heat stroke.
Pentose phosphate pathway activation via HSP27 phosphorylation by ATM kinase: A putative endogenous antioxidant defense mechanism during cerebral ischemia-reperfusion.
Phosphorylation enhances recombinant HSP27 neuroprotection against focal cerebral ischemia in mice.
Phosphorylation of HSP27 by Protein Kinase D Is Essential for Mediating Neuroprotection against Ischemic Neuronal Injury.
Preconditioning with +Gz acceleration (head-to-foot inertial load) produces neuroprotection against transient focal cerebral ischemia in rats.
Preferential expression of HSC70 heat shock mRNA in gerbil heart after transient brain ischemia.
Prior ischemic stress protects against experimental stroke.
Protective HSP70 Induction by Z-Ligustilide against Oxygen-Glucose Deprivation Injury via Activation of the MAPK Pathway but Not of HSF1.
Regional expression of heat shock protein-70 mRNA and c-fos mRNA following focal ischemia in rat brain.
Regulation of apoptotic and inflammatory cell signaling in cerebral ischemia: the complex roles of heat shock protein 70.
Serum levels of heat shock protein 27 in patients with acute ischemic stroke.
Stoichiometric Analysis of Shifting in Subcellular Compartmentalization of HSP70 within Ischemic Penumbra.
Suppression subtraction hybridization and northern analysis reveal upregulation of heat shock, trkB, and sodium calcium exchanger genes following global cerebral ischemia in the rat.
Synergistic induction of HSP40 and HSC70 in the mouse hippocampal neurons after cerebral ischemia and ischemic tolerance in gerbil hippocampus.
Targeted hsp70.1 disruption increases infarction volume after focal cerebral ischemia in mice.
Targeting expression of hsp70i to discrete neuronal populations using the Lmo-1 promoter: assessment of the neuroprotective effects of hsp70i in vivo and in vitro.
TAT-Hsp70 induces neuroprotection against stroke via anti-inflammatory actions providing appropriate cellular microenvironment for transplantation of neural precursor cells.
Time course of brain neuronal degeneration and heat shock protein (72) expression following neck tourniquet-induced cerebral ischemia in the rat.
Upregulation of dihydropyrimidinase-related protein 2, spectrin alpha II chain, heat shock cognate protein 70 pseudogene 1 and tropomodulin 2 after focal cerebral ischemia in rats--a proteomics approach.
Valproic acid reduces brain damage induced by transient focal cerebral ischemia in rats: potential roles of histone deacetylase inhibition and heat shock protein induction.
Very Delayed Remote Ischemic Post-conditioning Induces Sustained Neurological Recovery by Mechanisms Involving Enhanced Angioneurogenesis and Peripheral Immunosuppression Reversal.
[Effect of dl-3-N-butylphthalide on the expression of hsp70 mRNA and c-fos in transient cerebral ischemic and reperfused rat brain]
[Effects of Naomaitong Recipe on expressions of nuclear factor-kappaB and nitric-oxide synthases in brain tissue after focal cerebral ischemia reperfusion in aged rats.]
[Mild hypothermia combined with hydrogen sulfide alleviates hippocampal endoplasmic reticulum stress after global cerebral ischemia-reperfusion].
[Recent advances in pathophysiology and treatment of acute ischemic stroke]
Brain Neoplasms
Acquired resistance to 17-allylamino-17-demethoxygeldanamycin (17-AAG, tanespimycin) in glioblastoma cells.
Chaperonins in cancer: Expression, function, and migration in extracellular vesicles.
Concomitant alterations in distribution of 70 kDa heat shock proteins, cytoskeleton and organelles in heat shocked 9L cells.
Correlation between the progressive cytoplasmic expression of a novel small heat shock protein (Hsp16.2) and malignancy in brain tumors.
Different immunohistochemical levels of Hsp60 and Hsp70 in a subset of brain tumors and putative role of Hsp60 in neuroepithelial tumorigenesis.
Elevated levels of mortalin expression in human brain tumors.
Expression analysis of mortalin, a unique member of the Hsp70 family of proteins, in rat tissues.
Expression of heat shock proteins in brain tumors.
Geldanamycin induction of grp78 requires activation of reactive oxygen species via ER stress responsive elements in 9L rat brain tumour cells.
Gene expression profiling of metastatic brain cancer.
GRP78/BiP modulation of GRP78/BiP in altering sensitivity to chemotherapy.
Heat shock protein 70-binding protein 1 is highly expressed in high-grade gliomas, interacts with multiple heat shock protein 70 family members, and specifically binds brain tumor cell surfaces.
Immobilization stress induces the expression of alphaB-crystallin in rat hippocampus: implications of glial activation in stress-mediated hippocampal degeneration.
Immunoexpression patterns for Hypoxia-inducible Factor-1? and von Hippel-Lindau protein, in relation to Hsp90, of human brain tumors.
Involvement of Calcium-Mediated Reactive Oxygen Species in Inductive GRP78 Expression by Geldanamycin in 9L Rat Brain Tumor Cells.
Involvement of heat shock elements and basal transcription elements in the differential induction of the 70-kDa heat shock protein and its cognate by cadmium chloride in 9L rat brain tumor cells.
Mitochondrial calcium-mediated reactive oxygen species are essential for the rapid induction of the grp78 gene in 9L rat brain tumour cells.
Novel Functional Association of Serine Palmitoyltransferase Subunit 1-A Peptide in Sphingolipid Metabolism with Cytochrome P4501A1 Transactivation and Proliferative Capacity of the Human Glioma LN18 Brain Tumor Cell Line.
Pilot study of intratumoral injection of recombinant heat shock protein 70 in the treatment of malignant brain tumors in children.
Plasminogen kringle 5 induces apoptosis of brain microvessel endothelial cells: sensitization by radiation and requirement for GRP78 and LRP1.
Potential biomarkers of childhood brain tumor identified by proteomics of cerebrospinal fluid from extraventricular drainage (EVD).
Proteomic and Mitochondrial Genomic Analyses of Pediatric Brain Tumors.
Rapid induction of the Grp78 gene by cooperative actions of okadaic acid and heat-shock in 9L rat brain tumor cells--involvement of a cAMP responsive element-like promoter sequence and a protein kinase A signaling pathway.
Thapsigargin-induced grp78 expression is mediated by the increase of cytosolic free calcium in 9L rat brain tumor cells.
The small-molecule kinase inhibitor D11 counteracts 17-AAG-mediated up-regulation of HSP70 in brain cancer cells.
Transferrin Modified GSH Sensitive Hyaluronic Acid Derivative Micelle to Deliver HSP90 Inhibitors to Enhance the Therapeutic Efficacy of Brain Cancers.
Breast Neoplasms
"UPRegulation" of CD47 by the endoplasmic reticulum stress pathway controls anti-tumor immune responses.
(89)Zr-trastuzumab PET visualises HER2 downregulation by the HSP90 inhibitor NVP-AUY922 in a human tumour xenograft.
17-Allyamino-17-demethoxygeldanamycin and 17-NN-dimethyl ethylene diamine-geldanamycin have cytotoxic activity against multiple gynecologic cancer cell types.
17-allyamino-17-demethoxygeldanamycin treatment results in a magnetic resonance spectroscopy-detectable elevation in choline-containing metabolites associated with increased expression of choline transporter SLC44A1 and phospholipase A2.
17?AAG synergizes with Belinostat to exhibit a negative effect on the proliferation and invasion of MDA?MB?231 breast cancer cells.
17beta-hydroxysteroid dehydrogenase type 5 is negatively correlated to apoptosis inhibitor GRP78 and tumor-secreted protein PGK1, and modulates breast cancer cell viability and proliferation.
19-substituted Benzoquinone Ansamycin Heat Shock Protein 90 Inhibitors: Biological Activity and Decreased Off-target Toxicity.
89Zr-trastuzumab and 89Zr-bevacizumab PET to evaluate the effect of the HSP90 inhibitor NVP-AUY922 in metastatic breast cancer patients.
?B-crystallin Expression in Breast Cancer is Associated with Brain Metastasis.
A 27 kDa heat shock protein that has anomalous prognostic powers in early and advanced breast cancer.
A critical role for HSP90 in cancer cell invasion involves interaction with the extracellular domain of HER-2.
A kinase inhibitor screen reveals protein kinase C-dependent endocytic recycling of ErbB2 in breast cancer cells.
A Long Non-coding RNA Lnc712 Regulates Breast Cancer Cell Proliferation.
A multicenter trial evaluating retaspimycin HCL (IPI-504) plus trastuzumab in patients with advanced or metastatic HER2-positive breast cancer.
A Novel Agent Enhances the Chemotherapeutic Efficacy of Doxorubicin in MCF-7 Breast Cancer Cells.
A novel combination treatment for breast cancer cells involving BAPTA-AM and proteasome inhibitor bortezomib.
A novel HSP90 inhibitor targeting the C-terminal domain attenuates trastuzumab resistance in HER2-positive breast cancer.
A novel role for DYX1C1, a chaperone protein for both Hsp70 and Hsp90, in breast cancer.
A phase I trial of ganetespib in combination with paclitaxel and trastuzumab in patients with human epidermal growth factor receptor-2 (HER2)-positive metastatic breast cancer.
A phase I-II study of the histone deacetylase inhibitor vorinostat plus sequential weekly paclitaxel and doxorubicin-cyclophosphamide in locally advanced breast cancer.
A Phase II Open-Label Study of Ganetespib, a Novel Heat Shock Protein 90 Inhibitor for Patients With Metastatic Breast Cancer.
A phase II study of 17-allylamino-17-demethoxygeldanamycin in metastatic or locally advanced, unresectable breast cancer.
A small molecule designed to bind to the adenine nucleotide pocket of Hsp90 causes Her2 degradation and the growth arrest and differentiation of breast cancer cells.
Activation of mitochondrial unfolded protein response is associated with Her2-overexpression breast cancer.
Activity of suberoylanilide hydroxamic Acid against human breast cancer cells with amplification of her-2.
Additive viability-loss following hsp70/hsc70 double interference and Hsp90 inhibition in two breast cancer cell lines.
Advances in the clinical development of heat shock protein 90 (Hsp90) inhibitors in cancers.
AIDing cancer treatment: Reducing AID activity via HSP90 inhibition.
Alkaloid derivative ION-31a inhibits breast cancer metastasis and angiogenesis by targeting HSP90?.
Alpha B crystallin expression in response to hormone, oncogenes and stress.
alphaB-crystallin is a marker of aggressive breast cancer behavior but does not independently predict for patient outcome: a combined analysis of two randomized studies.
AlphaB-crystallin is a novel oncoprotein that predicts poor clinical outcome in breast cancer.
Altered molecular pathways decides the treatment outcome of Hsp90 inhibitors against breast cancer cells.
Amplification and high-level expression of heat shock protein 90 marks aggressive phenotypes of human epidermal growth factor receptor 2 negative breast cancer.
An investigation into the potential use of serum Hsp70 as a novel tumour biomarker for Hsp90 inhibitors.
An investigation of heat shock protein 27 and P-glycoprotein mediated multi-drug resistance in breast cancer using liquid chromatography-tandem mass spectrometry-based targeted proteomics.
Androgen receptor and heat shock protein 27 co-regulate the malignant potential of molecular apocrine breast cancer.
Angiogenesis impairment in Id-deficient mice cooperates with an Hsp90 inhibitor to completely suppress HER2/neu-dependent breast tumors.
Anti-tumor activity of the Hsp90 inhibitor IPI-504 in HER2 positive trastuzumab-resistant breast cancer.
Antibodies to heat shock protein 90 in osteosarcoma patients correlate with response to neoadjuvant chemotherapy.
Antibodies to heat-shock protein 27 are associated with improved survival in patients with breast cancer.
Anticancer effects of the Hsp90 inhibitor 17-demethoxy-reblastatin in human breast cancer MDA-MB-231 cells.
Antitumor immune responses mediated by adenoviral GDEPT using nitroreductase/CB1954 is enhanced by high-level coexpression of heat shock protein 70.
Assessment of wastewater-irrigated soil containing heavy metals and establishment of specific biomarkers.
Associations of HSP90 client proteins in human breast cancer.
AT-533, a novel Hsp90 inhibitor, inhibits breast cancer growth and HIF-1?/VEGF/VEGFR-2-mediated angiogenesis in vitro and in vivo.
Autoantibodies to the 90kDa heat shock protein and poor survival in breast cancer patients.
Autophagy Blockade by Ai Du Qing Formula Promotes Chemosensitivity of Breast Cancer Stem Cells Via GRP78/?-Catenin/ABCG2 Axis.
BAG-1/SODD, HSP70 and HSP90 are potential prognostic markers of poor survival in node-negative breast carcinoma.
BAG-i expression in human breast cancer: interrelationship between BAG-1 RNA, protein, HSC70 expression and clinico-pathological data.
Betulinic acid chemosensitizes breast cancer by triggering ER stress-mediated apoptosis by directly targeting GRP78.
BIK and GRP78 protein expression as possible markers of response to preoperative chemotherapy and survival in breast cancer.
Bioactivity-Guided Identification and Cell Signaling Technology to Delineate the Lactate Dehydrogenase A Inhibition Effects of Spatholobus suberectus on Breast Cancer.
Biochemical requirements for the expression of heat shock protein 72 kda in human breast cancer MCF-7 cells.
Biological and clinical significance of HER2 overexpression in breast cancer.
BJ-B11, an Hsp90 Inhibitor, Constrains the Proliferation and Invasion of Breast Cancer Cells.
Blockade of GRP78 sensitizes breast cancer cells to microtubules-interfering agents that induce the unfolded protein response.
Blockage of conformational changes of heat shock protein gp96 on cell membrane by a ?-helix peptide inhibits HER2 dimerization and signaling in breast cancer.
Blocking HSF1 by dominant-negative mutant to sensitize tumor cells to hyperthermia.
Bortezomib blocks the catabolic process of autophagy via a cathepsin-dependent mechanism, affects endoplasmic reticulum stress and induces caspase-dependent cell death in antiestrogen-sensitive and resistant ER+ breast cancer cells.
Breast cancer and HSP90 inhibitors: is there a role beyond the HER2-positive subtype?
Breast cancer metastasis suppressor 1 (BRMS1) is stabilized by the Hsp90 chaperone.
C-terminal HSP90 inhibitor L80 elicits anti-metastatic effects in triple-negative breast cancer via STAT3 inhibition.
Calpain Genetic Disruption and HSP90 Inhibition Combine To Attenuate Mammary Tumorigenesis.
Carbamazepine promotes Her-2 protein degradation in breast cancer cells by modulating HDAC6 activity and acetylation of Hsp90.
Cell surface expression of the stress response chaperone GRP78 enables tumor targeting by circulating ligands.
Cell Surface GRP78 Accelerated Breast Cancer Cell Proliferation and Migration by Activating STAT3.
Cell surface GRP78 and Dermcidin cooperate to regulate breast cancer cell migration through Wnt signaling.
Cell surface GRP78 promotes stemness in normal and neoplastic cells.
Cell surface GRP78: A potential marker of good prognosis and response to chemotherapy in breast cancer.
Cellular stress stimulates nuclear localization signal (NLS) independent nuclear transport of MRJ.
Chemotherapy Controls Metastasis Through Stimulatory Effects on GRP78 and Its Transcription Factor CREB3L1.
Chromatographic separation of eight progesterone receptor isoforms in human breast tumors, and detection by radioligand and monoclonal antibodies. Association with hsp90 and hsp70 heat shock proteins.
Co-expression of steroid receptors (estrogen receptor alpha and/or progesterone receptors) and Her-2/neu: Clinical implications.
Combining cytotoxics and 17-allylamino, 17-demethoxygeldanamycin: sequence and tumor biology matters. Commentary re: P. Münster et al., Modulation of Hsp90 function by ansamycins sensitizes breast cancer cells to chemotherapy-induced apoptosis in an RB- and schedule-dependent manner. Clin. Cancer Res., 7: 2228-2236, 2001.
Comparison of Functional Proteomic Analyses of Human Breast Cancer Cell Lines T47D and MCF7.
Comparison of inhibitory effects of 17-AAG nanoparticles and free 17-AAG on HSP90 gene expression in breast cancer.
Constitutive overexpression of the 27,000 dalton heat shock protein in late passage human breast cancer cells.
Contributions of co-chaperones and post-translational modifications towards Hsp90 drug sensitivity.
Correlation of heat shock protein (HSP70) expression with cell proliferation (MIB1), estrogen receptors (ER) and clinicopathological variables in invasive ductal breast carcinomas.
Correlation of heat shock protein 70 expression with estrogen receptor levels in invasive human breast cancer.
Correlation of the protein expression of GRP78 and BIK/NBK with prognostic markers in patients with breast cancer and neoadjuvant chemotherapy.
Could Increased Expression of Hsp27, an "Anti-Inflammatory" Chaperone, Contribute to the Monocyte-Derived Dendritic Cell Bias towards Tolerance Induction in Breast Cancer Patients?
Critical role of the stress chaperone GRP78/BiP in tumor proliferation, survival, and tumor angiogenesis in transgene-induced mammary tumor development.
DCZ3112, a novel Hsp90 inhibitor, exerts potent antitumor activity against HER2-positive breast cancer through disruption of Hsp90-Cdc37 interaction.
De-acetylation and degradation of HSPA5 is critical for E1A metastasis suppression in breast cancer cells.
De-regulation of GRP stress protein expression in human breast cancer cell lines.
Deciphering the Inhibition Mechanism of under Trial Hsp90 Inhibitors and Their Analogues: A Comparative Molecular Dynamics Simulation.
Design and synthesis of pyrimidinyl acyl thioureas as novel Hsp90 inhibitors in invasive ductal breast cancer and its bone metastasis.
Design of novel Geldanamycin analogue hsp90 alpha-inhibitor in silico for breast cancer therapy.
Design, synthesis and biological evaluation of biphenylamide derivatives as Hsp90 C-terminal inhibitors.
Design, synthesis and pharmacological evaluation of 4,5-diarylisoxazols bearing amino acid residues within the 3-amido motif as potent heat shock protein 90 (Hsp90) inhibitors.
Design, synthesis, and evaluation of a radicicol and geldanamycin chimera, radamide.
Design, Synthesis, and Evaluation of Heat Shock Protein 90 Inhibitors in Human Breast Cancer and Its Metastasis.
Designed TPR modules as novel anticancer agents.
Destabilization of steroid receptors by heat shock protein 90-binding drugs: a ligand-independent approach to hormonal therapy of breast cancer.
Development of Phenyl Cyclohexylcarboxamides as a Novel Class of Hsp90 C-terminal Inhibitors.
Dietary compound isoliquiritigenin targets GRP78 to chemosensitize breast cancer stem cells via ?-catenin/ABCG2 signaling.
Differential Expression of HSP90? in MDA-MB-231 and MCF-7 Cell Lines after Treatment with Doxorubicin.
Discovery of a novel unfolded protein response phenotype of cancer stem/progenitor cells from the bone marrow of breast cancer patients.
Discovery of a simplified deguelin analog as an HSP90 C-terminal inhibitor for HER2-positive breast cancer.
Discovery of diamine-linked 17-aroylamido-17-demethoxygeldanamycins as potent Hsp90 inhibitors.
Discovery of N-pyridoyl-?2 -pyrazolines as Hsp90 inhibitors.
Discovery of novel anti-breast cancer agents derived from deguelin as inhibitors of heat shock protein 90 (HSP90).
Distribution of Hsp-27 and HER-2/neu in in situ and invasive ductal breast carcinomas.
DNAJB6 governs a novel regulatory loop determining Wnt/?-catenin signalling activity.
Docosahexaenoic Acid-mediated Inhibition of Heat Shock Protein 90-p23 Chaperone Complex and Downstream Client Proteins in Lung and Breast Cancer.
Down-regulation of heat-shock protein 70 (HSP-70) correlated with responsiveness to neoadjuvant aromatase inhibitor therapy in breast cancer patients.
Down-regulation of RIP expression by 17-dimethylaminoethylamino-17-demethoxygeldanamycin promotes TRAIL-induced apoptosis in breast tumor cells.
Effects of exogenous human leptin on heat shock protein 70 expression in MCF-7 breast cancer cells and breast carcinoma of nude mice xenograft model.
Effects of HIV protease inhibitor ritonavir on Akt-regulated cell proliferation in breast cancer.
Elevated expression of nuclear Hsp90 in invasive breast tumors.
Elevated serum levels of heat shock protein 70 are associated with breast cancer.
Endoplasmic Reticulum Stress Protein GRP78 Modulates Lipid Metabolism to Control Drug Sensitivity and Antitumor Immunity in Breast Cancer.
Endoplasmic reticulum stress-induced exosomal miR-27a-3p promotes immune escape in breast cancer via regulating PD-L1 expression in macrophages.
Eradication of breast cancer xenografts by hyperthermic suicide gene therapy under the control of the heat shock protein promoter.
Eradication of murine mammary adenocarcinoma through HSVtk expression directed by the glucose-starvation inducible grp78 promoter.
Estrogen receptor alpha and beta subtype expression and transactivation capacity are differentially affected by receptor-, hsp90- and immunophilin-ligands in human breast cancer cells.
Evaluation of Newcastle disease virus mediated dendritic cell activation and cross-priming tumor-specific immune responses ex vivo.
Exploiting heat shock protein expression to develop a non-invasive diagnostic tool for breast cancer.
Expression and roles of heat shock proteins in human breast cancer.
Expression of glucose-regulated protein 78 as prognostic biomarkers for triple-negative breast cancer.
Expression of heat shock protein 70 and c-myc protein in human breast cancer: an immunohistochemical study.
Expression of hsp90 and cyclin D1 in human breast cancer.
Expression of the Brn-3b transcription factor correlates with expression of HSP-27 in breast cancer biopsies and is required for maximal activation of the HSP-27 promoter.
Expression of the molecular chaperone ?B-crystallin in infiltrating ductal breast carcinomas and the significance thereof: an immunohistochemical and proteomics-based strategy.
Expression of tumor antigens and heat-shock protein 70 in breast cancer cells after high-intensity focused ultrasound ablation.
Extracellular heat shock protein (Hsp)70 and Hsp90? assist in matrix metalloproteinase-2 activation and breast cancer cell migration and invasion.
Extragonadal teratocarcinoma in chimeric mice.
Flotillin depletion affects ErbB protein levels in different human breast cancer cells.
From Bacteria to Cancer: A Benzothiazole-Based DNA Gyrase B Inhibitor Redesigned for Hsp90 C-Terminal Inhibition.
Functional pathways shared by liver and lung metastases: a mitochondrial chaperone machine is up-regulated in soft-tissue breast cancer metastasis.
Functional proteomics of breast cancer for signal pathway profiling and target discovery.
FW-04-806 inhibits proliferation and induces apoptosis in human breast cancer cells by binding to N-terminus of Hsp90 and disrupting Hsp90-Cdc37 complex formation.
Ganetespib overcomes resistance to PARP inhibitors in breast cancer by targeting core proteins in the DNA repair machinery.
Ganetespib targets multiple levels of the receptor tyrosine kinase signaling cascade and preferentially inhibits ErbB2-overexpressing breast cancer cells.
Genetic variation in the tumor necrosis factor-alpha promoter region and in the stress protein hsp70-2: susceptibility and prognostic implications in breast carcinoma.
Glucose regulated protein 78 (GRP78) inhibits apoptosis and attentinutes chemosensitivity of gemcitabine in breast cancer cell via AKT/mitochondrial apoptotic pathway.
Glucose-regulated protein 78 as a novel effector of BRCA1 for inhibiting stress-induced apoptosis.
Glucose-regulated protein 78 controls cross-talk between apoptosis and autophagy to determine antiestrogen responsiveness.
Gp96 and its different expression in breast carcinomas.
GRP78 as a Novel Predictor of Responsiveness to Chemotherapy in Breast Cancer.
GRP78 as potential predictor for breast cancer response to adjuvant taxane therapy.
GRP78 expression in peripheral blood mononuclear cells is a new predictive marker for the benefit of taxanes in breast cancer neoadjuvant treatment.
GRP78 mediates radiation resistance of a stem cell-like subpopulation within the MCF-7 breast cancer cell line.
GRP78 regulates CD44v membrane homeostasis and cell spreading in tamoxifen-resistant breast cancer.
GRP78/BiP inhibits endoplasmic reticulum BIK and protects human breast cancer cells against estrogen starvation-induced apoptosis.
GRP94 overexpression as an indicator of unfavorable outcomes in breast cancer patients.
HBP21: A Novel Member of TPR Motif Family, as a Potential Chaperone of Heat Shock Protein 70 in Proliferative Vitreoretinopathy (PVR) and Breast Cancer.
Heat shock cognate 70 mutations in sporadic breast carcinoma.
Heat shock cognate 70 protein secretion as a new growth arrest signal for cancer cells.
Heat shock protein 27 and gross cystic disease fluid protein 15 play critical roles in molecular apocrine breast cancer.
Heat shock protein 27 differentiates tolerogenic macrophages that may support human breast cancer progression.
Heat Shock Protein 27 Enhances SUMOylation of Heat Shock Protein B8 to Accelerate the Progression of Breast Cancer.
Heat shock protein 27 is associated with decreased survival in node-negative breast cancer patients.
Heat shock protein 27 overexpression in breast cancer lymph node metastasis.
Heat shock protein 27 plays two distinct roles in controlling human breast cancer cell migration on laminin-5.
Heat shock protein 27 protects against aminolevulinic acid-mediated photodynamic therapy-induced apoptosis and necrosis in human breast cancer cells.
Heat shock protein 70-2 (HSP70-2) overexpression in breast cancer.
Heat shock protein 90 (hsp90) expression and breast cancer.
Heat Shock Protein 90 Family Isoforms as Prognostic Biomarkers and Their Correlations with Immune Infiltration in Breast Cancer.
Heat shock protein 90 is a rational molecular target in breast cancer.
Heat Shock Protein 90 Triggers Multi-Drug Resistance of Ovarian Cancer via AKT/GSK3?/?-Catenin Signaling.
Heat shock protein 90? stabilizes focal adhesion kinase and enhances cell migration and invasion in breast cancer cells.
Heat shock protein as molecular targets for breast cancer therapeutics.
Heat shock protein expression and drug resistance in breast cancer patients treated with induction chemotherapy.
Heat shock protein gp96 and CD4+ and CD8+ T-lymphocytes expression as prognostic factors in various molecular types of invasive breast carcinoma.
Heat shock protein hsp70 in patients with axillary lymph node-negative breast cancer: prognostic implications.
Heat shock protein-90-alpha, a prolactin-STAT5 target gene identified in breast cancer cells, is involved in apoptosis regulation.
Heat shock protein90 in lobular neoplasia of the breast.
Heat shock proteins in breast cancer progression--a suitable case for treatment?
Heat Shock Proteins: A Potential Anticancer Target.
Heat-shock protein 70 as a prognostic marker in node-negative breast cancer.
Her2 promotes early dissemination of breast cancer by suppressing the p38-MK2-Hsp27 pathway that is targetable by Wip1 inhibition.
HER2/ErbB2 activates HSF1 and thereby controls HSP90 clients including MIF in HER2-overexpressing breast cancer.
HER3-Mediated Resistance to Hsp90 Inhibition Detected in Breast Cancer Xenografts by Affibody-Based PET Imaging.
Heregulin up-regulates heat shock protein-70 expression in breast cancer cells.
HEXIM1 controls P-TEFb processing and regulates drug sensitivity in triple-negative breast cancer.
HHQ-4, a quinoline derivate, preferentially inhibits proliferation of glucose-deprived breast cancer cells as a GRP78 down-regulator.
High capacity nanoporous silicon carrier for systemic delivery of gene silencing therapeutics.
High HSP90 expression is associated with decreased survival in breast cancer.
High Level of Radiation-Induced Heat Shock Protein with a Molecular Weight of 27 and 70 kDa is the Hallmark of Radioresistant SP Cells of MCF-7 Breast Cancer Culture.
High Levels of Hsp90 Cochaperone p23 Promote Tumor Progression and Poor Prognosis in Breast Cancer by Increasing Lymph Node Metastases and Drug Resistance.
High risk for cardiovascular disease in postmenopausal breast cancer survivors.
HN1L promotes migration and invasion of breast cancer by up-regulating the expression of HMGB1.
Hormone-refractory breast cancer remains sensitive to the antitumor activity of heat shock protein 90 inhibitors.
Hsp25 and Hsp70 in rodent tumors treated with doxorubicin and lovastatin.
Hsp27 expression in neuroblastoma: correlation with disease stage.
Hsp27 overexpression inhibits doxorubicin-induced apoptosis in human breast cancer cells.
Hsp27-induced MMP-9 expression is influenced by the Src tyrosine protein kinase yes.
Hsp90 binds directly to fibronectin (FN) and inhibition reduces the extracellular fibronectin matrix in breast cancer cells.
Hsp90 chaperone facilitates E2F1/2-dependent gene transcription in human breast cancer cells.
HSP90 empowers evolution of resistance to hormonal therapy in human breast cancer models.
HSP90 expression and its association with wighteone metabolite response in HER2-positive breast cancer cells.
Hsp90 in the continuum of breast ductal carcinogenesis: Evaluation in precursors, preinvasive and ductal carcinoma lesions.
HSP90 Inhibition Is Effective in Breast Cancer: A Phase II Trial of Tanespimycin (17-AAG) Plus Trastuzumab in Patients with HER2-Positive Metastatic Breast Cancer Progressing on Trastuzumab.
Hsp90 Inhibition Results in Glucocorticoid Receptor Degradation in Association with Increased Sensitivity to Paclitaxel in Triple-Negative Breast Cancer.
Hsp90 inhibitor 17-AAG reduces ErbB2 levels and inhibits proliferation of the trastuzumab resistant breast tumor cell line JIMT-1.
HSP90 inhibitor antagonizing MIF: The specifics of pleiotropic cancer drug candidates.
HSP90 inhibitor AUY922 abrogates up-regulation of RTKs by mTOR inhibitor AZD8055 and potentiates its antiproliferative activity in human breast cancer.
HSP90 inhibitor AUY922 can reverse Fulvestrant induced feedback reaction in human breast cancer cells.
HSP90 inhibitor PU-H71 increases radiosensitivity of breast cancer cells metastasized to visceral organs and alters the levels of inflammatory mediators.
Hsp90 inhibitor PU-H71, a multimodal inhibitor of malignancy, induces complete responses in triple-negative breast cancer models.
HSP90 Inhibitor, 17-DMAG, Alone and in Combination with Lapatinib Attenuates Acquired Lapatinib-Resistance in ER-positive, HER2-Overexpressing Breast Cancer Cell Line.
Hsp90 inhibitor-loaded IR780 micelles for mitochondria-targeted mild-temperature photothermal therapy in xenograft models of human breast cancer.
Hsp90 inhibitor-mediated disruption of chaperone association of ATR with hsp90 sensitizes cancer cells to DNA damage.
Hsp90 Inhibitor; NVP-AUY922 in Combination with Doxorubicin Induces Apoptosis and Downregulates VEGF in MCF-7 Breast Cancer Cell Line.
Hsp90 inhibitors and drug resistance in cancer: The potential benefits of combination therapies of Hsp90 inhibitors and other anti-cancer drugs.
HSP90 inhibitors decrease AID levels and activity in mice and in human cells.
Hsp90 inhibitors in breast cancer: A systematic review.
HSP90 modulates actin dynamics: Inhibition of HSP90 leads to decreased cell motility and impairs invasion.
Hsp90 molecular chaperone inhibitors: are we there yet?
Hsp90 regulates HDAC3-dependent gene transcription while HDAC3 regulates the functions of Hsp90.
Hsp90 rescues PTK6 from proteasomal degradation in breast cancer cells.
HSP90, HSPA8, HIF-1 alpha and HSP70-2 polymorphisms in breast cancer: a case-control study.
Hsp90: A Global Regulator of the Genotype-to-Phenotype Map in Cancers.
Hsp90: a novel target for cancer therapy.
Hsp90: an emerging target for breast cancer therapy.
Hsp90? Mediates BMI1 Expression in Breast Cancer Stem/Progenitor Cells through Facilitating Nuclear Translocation of c-Myc and EZH2.
Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer: Heat Shock Protein 90 Overexpression, Ki67 Proliferative Index, and Topoisomerase II-? Co-amplification as Predictors of Pathologic Complete Response to Neoadjuvant Chemotherapy With Trastuzumab and Docetaxel.
Humanization of a mouse monoclonal antibody directed against a cell surface-exposed epitope of membrane-associated heat shock protein 70 (Hsp70).
Identification of a new panel of serum autoantibodies associated with the presence of in situ carcinoma of the breast in younger women.
Identification of a new scaffold for hsp90 C-terminal inhibition.
Identification of an HSP90 modulated multi-step process for ERBB2 degradation in breast cancer cells.
Identification of breast cancer metastasis-associated proteins in an isogenic tumor metastasis model using two-dimensional gel electrophoresis and liquid chromatography-ion trap-mass spectrometry.
Identification of heat shock protein 90 and other proteins as tumour antigens by serological screening of an ovarian carcinoma expression library.
Identification of HSP90 as a new GABARAPL1 (GEC1)-interacting protein.
Identification of keratins 18, 19 and heat-shock protein 90 beta as candidate substrates of proteolysis during ionizing radiation-induced apoptosis of estrogen-receptor negative breast tumor cells.
IGFBP-3 binds GRP78, stimulates autophagy and promotes the survival of breast cancer cells exposed to adverse microenvironments.
IGFBP-3 sensitizes antiestrogen-resistant breast cancer cells through interaction with GRP78.
Immunization with Murine Breast Cancer Cells Treated with Antisense Oligodeoxynucleotides to Type I Insulin-Like Growth Factor Receptor Induced an Antitumoral Effect Mediated by a CD8+ Response Involving Fas/Fas Ligand Cytotoxic Pathway.
Improvement of protein immobilization for the elaboration of tumor-associated antigen microarrays: application to the sensitive and specific detection of tumor markers from breast cancer sera.
In silico design of small peptide-based Hsp90 inhibitor: A novel anticancer agent.
In vitro study comparing the efficacy of the water-soluble HSP90 inhibitors, 17-AEPGA and 17-DMAG, with that of the non?water-soluble HSP90 inhibitor, 17-AAG, in breast cancer cell lines.
Increased heat shock protein 70 (Hsp70) serum levels and low NK cell counts after radiotherapy - potential markers for predicting breast cancer recurrence?
Indolylkojyl methane analogue IKM5 potentially inhibits invasion of breast cancer cells via attenuation of GRP78.
Inducible heat shock protein 70 expression as a potential predictive marker of metastasis in breast tumors.
Induction of complete regressions of oncogene-induced breast tumors in mice.
Induction of Hsp22 (HspB8) by estrogen and the metalloestrogen cadmium in estrogen receptor-positive breast cancer cells.
Induction of the estrogen-regulated "24K" protein by heat shock.
Inhibiting the HSP90 chaperone destabilizes macrophage migration inhibitory factor and thereby inhibits breast tumor progression.
Inhibition of 17beta-hydroxysteroid dehydrogenase type 7 modulates breast cancer protein profile and enhances apoptosis by down-regulating GRP78.
Inhibition of Established Micrometastases by Targeted Drug Delivery via Cell Surface Associated GRP78.
Inhibition of ezrin causes PKC?-mediated internalization of erbb2/HER2 tyrosine kinase in breast cancer cells.
Inhibition of heat shock protein (Hsp) 27 potentiates the suppressive effect of Hsp90 inhibitors in targeting breast cancer stem-like cells.
Inhibition of heat shock protein 27-mediated resistance to DNA damaging agents by a novel PKC delta-V5 heptapeptide.
Inhibition of heat shock protein 90 function by ansamycins causes the morphological and functional differentiation of breast cancer cells.
Inhibition of mitogen-activated protein kinase signaling pathway sensitizes breast cancer cells to endoplasmic reticulum stress-induced apoptosis.
Interaction between GRP78 and IGFBP-3 Affects Tumourigenesis and Prognosis in Breast Cancer Patients.
Intrinsic proteotoxic stress levels vary and act as a predictive marker for sensitivity of cancer cells to Hsp90 inhibition.
Intronic polymorphism (1541-1542delGT) of the constitutive heat shock protein 70 gene has functional significance and shows evidence of association with lung cancer risk.
Investigation of the role of quercetin as a heat shock protein inhibitor on apoptosis in human breast cancer cells.
Involvement of heat shock protein 27 in the susceptibility of KT human breast cancer cells to UVC and interferon lethality.
Is the small heat shock protein alphaB-crystallin an oncogene?
Isolation of a Novel Thioflavin S-Derived Compound that Inhibits BAG-1-Mediated Protein Interactions and Targets BRAF Inhibitor-Resistant Cell Lines.
KEGG-expressed genes and pathways in triple negative breast cancer: Protocol for a systematic review and data mining.
l-Peptide functionalized dual-responsive nanoparticles for controlled paclitaxel release and enhanced apoptosis in breast cancer cells.
Lack of association between tumor necrosis and hsp-27 expression in primary breast cancer.
Leptin as a mediator of tumor-stromal interactions promotes breast cancer stem cell activity.
Leptin increases HER2 protein levels through a STAT3-mediated up-regulation of Hsp90 in breast cancer cells.
Leveraging ectopic Hsp90 expression to assay the presence of tumor cells and aggressive tumor phenotypes in breast specimens.
Ligand-independent and agonist-mediated degradation of estrogen receptor-alpha in breast carcinoma cells: evidence for distinct degradative pathways.
Long non-coding RNA NKILA regulates expression of HSP90?, NF-?B and ?-catenin proteins in the MCF-7 breast cancer cell line.
Macrophage migration inhibitory factor involvement in breast cancer (Review).
Magnetic resonance spectroscopy detectable metabolomic fingerprint of response to antineoplastic treatment.
Magnetic thermoablation stimuli alter BCL2 and FGF-R1 but not HSP70 expression profiles in BT474 breast tumors.
Marked enhancement of lysosomal targeting and efficacy of ErbB2-targeted drug delivery by HSP90 inhibition.
Measuring Tumor Epichaperome Expression Using [124I] PU-H71 Positron Emission Tomography as a Biomarker of Response for PU-H71 Plus Nab-Paclitaxel in HER2-Negative Metastatic Breast Cancer.
Medulloblastoma sensitivity to 17-allylamino-17-demethoxygeldanamycin requires MEK/ERKM.
Metabolism and Excretion of 6-Chloro-9-(4-methoxy-3,5-dimethylpyridin-2-ylmethyl)-9H-purin-2-ylamine (BIIB021), an HSP90 Inhibitor, in Rats and Dogs, and Assessment of its Metabolic Profile in Plasma of Humans.
Metastasis and the Tumor Microenvironment: A Joint Metastasis Research Society-AACR Conference - Research on Metastasis: Part 2.
Metformin inhibits proliferation and promotes apoptosis of HER2 positive breast cancer cells by downregulating HSP90.
MHC-class-I expression in human breast cancer correlates with nuclear localization of the 90 kDa heat-shock-protein.
MicroRNAs and Heat Shock Proteins in Breast Cancer Biology.
Mitochondrial autophagosomes as a mechanism of drug resistance in breast carcinoma.
Mitotic catastrophe cell death induced by heat shock protein 90 inhibitor in BRCA1-deficient breast cancer cell lines.
Modeling spheroid growth, PET tracer uptake, and treatment effects of the Hsp90 inhibitor NVP-AUY922.
Modelling the effect of GRP78 on anti-oestrogen sensitivity and resistance in breast cancer.
Modulation of expression of heat shock proteins and apoptosis by Flueggea leucopyrus (Willd) decoction in three breast cancer phenotypes.
Modulation of Hsp90 function by ansamycins sensitizes breast cancer cells to chemotherapy-induced apoptosis in an RB- and schedule-dependent manner. See: E. A. Sausville, Combining cytotoxics and 17-allylamino, 17-demethoxygeldanamycin: sequence and tumor biology matters, Clin. Cancer Res., 7: 2155-2158, 2001.
Molecular chaperones in mammary cancer growth and breast tumor therapy.
Molecular pathways: targeting hsp90--who benefits and who does not.
Molecular signature of response and potential pathways related to resistance to the HSP90 inhibitor, 17AAG, in breast cancer.
Monoclonal antibody 4C5 prevents activation of MMP2 and MMP9 by disrupting their interaction with extracellular HSP90 and inhibits formation of metastatic breast cancer cell deposits.
Mortalin antibody-conjugated quantum dot transfer from human mesenchymal stromal cells to breast cancer cells requires cell-cell interaction.
Mortalin maintains breast cancer stem cells stemness via activation of Wnt/GSK3?/?-catenin signaling pathway.
Mortalin promotes breast cancer malignancy.
Multiclass comparative virtual screening to identify novel Hsp90 inhibitors: a therapeutic breast cancer drug target.
Nanoengineered Disruption of Heat Shock Protein 90 Targets Drug-Induced Resistance and Relieves Natural Killer Cell Suppression in Breast Cancer.
Natural compounds as potential Hsp90 inhibitors for breast cancer-Pharmacophore guided molecular modelling studies.
Natural state of mutant p53 protein and heat shock protein 70 in breast cancer tissues.
Neoisoliquiritigenin inhibits tumor progression by targeting GRP78-?-catenin signaling in breast cancer.
Neratinib induces ErbB2 ubiquitylation and endocytic degradation via HSP90 dissociation in breast cancer cells.
New novobiocin analogues as antiproliferative agents in breast cancer cells and potential inhibitors of heat shock protein 90.
NHF-derived carbon dots: prevalidation approach in breast cancer treatment.
Nm23-H1 metastasis suppressor expression level influences the binding properties, stability, and function of the kinase suppressor of Ras1 (KSR1) Erk scaffold in breast carcinoma cells.
Non-Benzoquinone Geldanamycin Analog, WK-88-1, Induces Apoptosis in Human Breast Cancer Cell Lines.
Novel C-terminal heat shock protein 90 inhibitors target breast cancer stem cells and block migration, self-renewal, and epithelial-mesenchymal transition.
Novel Hsp90 inhibitor FW-04-806 displays potent antitumor effects in HER2-positive breast cancer cells as a single agent or in combination with lapatinib.
Novel Mechanism of Anti-apoptotic Function of 78-kDa Glucose-regulated Protein (GRP78): ENDOCRINE RESISTANCE FACTOR IN BREAST CANCER, THROUGH RELEASE OF B-CELL LYMPHOMA 2 (BCL-2) FROM BCL-2-INTERACTING KILLER (BIK).
Novel nuclear matrix protein HET binds to and influences activity of the HSP27 promoter in human breast cancer cells.
Novobiocin decreases SMYD3 expression and inhibits the migration of MDA-MB-231 human breast cancer cells.
NVP-AUY922: a small molecule HSP90 inhibitor with potent antitumor activity in preclinical breast cancer models.
Oleandrin, a cardiac glycoside, induces immunogenic cell death via the PERK/elF2?/ATF4/CHOP pathway in breast cancer.
Optical and radioiodinated tethered hsp90 inhibitors reveal selective internalization of ectopic hsp90 in malignant breast tumor cells.
Optical imaging with her2-targeted affibody molecules can monitor hsp90 treatment response in a breast cancer xenograft mouse model.
Osteopontin increases breast cancer cell sensitivity to specific signaling pathway inhibitors in preclinical models.
Ovarian Serous Carcinoma With a Novel HSP90AB1 Mutation in a Patient With Synchronous Primary Fallopian Tube Serous Carcinoma.
Overexpression of molecular chaperons GRP78 and GRP94 in CD44(hi)/CD24(lo) breast cancer stem cells.
Overexpression of the glucose-regulated stress gene GRP78 in malignant but not benign human breast lesions.
P-Cadherin and beta-catenin are useful prognostic markers in breast cancer patients; beta-catenin interacts with heat shock protein Hsp27.
p53 protein accumulation detected by five different antibodies: relationship to prognosis and heat shock protein 70 in breast cancer.
Paclitaxel-doxorubicin sequence is more effective in breast cancer cells with heat shock protein 27 overexpression.
Patient-derived heavy chain antibody targets cell surface HSP90 on breast tumors.
PCDHGB7 Increases Chemosensitivity to Carboplatin by Inhibiting HSPA9 via Inducing Apoptosis in Breast Cancer.
Peptide-conjugated antisense oligonucleotides for targeted inhibition of a transcriptional regulator in vivo.
PGK1-coupled HSP90 stabilizes GSK3? expression to regulate the stemness of breast cancer stem cells.
Phage display derived human monoclonal antibodies isolated by binding to the surface of live primary breast cancer cells recognize GRP78.
Pharmacological induction of cell surface GRP78 contributes to apoptosis in triple negative breast cancer cells.
Phase 1B/2 study of the HSP90 inhibitor AUY922 plus trastuzumab in metastatic HER2-positive breast cancer patients who have progressed on trastuzumab-based regimen.
Phase I-II study of vorinostat plus paclitaxel and bevacizumab in metastatic breast cancer: evidence for vorinostat-induced tubulin acetylation and Hsp90 inhibition in vivo.
Plumbagin sensitizes breast cancer cells to tamoxifen-induced cell death through GRP78 inhibition and Bik upregulation.
PNSA, a Novel C-Terminal Inhibitor of HSP90, Reverses Epithelial-Mesenchymal Transition and Suppresses Metastasis of Breast Cancer Cells In Vitro.
Polymorphism in the tumor necrosis factor-alpha promotor region and in the heat shock protein 70 genes associated with malignant tumors.
Potential prognostic value of heat-shock protein 90 in the presence of phosphatidylinositol-3-kinase overexpression or loss of PTEN, in invasive breast cancers.
Potential Prognostic Value of Histone Deacetylase 6 and Acetylated Heat-Shock Protein 90 in Early-Stage Breast Cancer.
Practical p-value adjustment for optimally selected cutpoints.
PRDM14 directly interacts with heat shock proteins HSP90? and glucose-regulated protein 78.
Preclinical antitumor activity of the novel heat shock protein 90 inhibitor CH5164840 against human epidermal growth factor receptor 2 (HER2)-overexpressing cancers.
Prodigiosin activates endoplasmic reticulum stress cell death pathway in human breast carcinoma cell lines.
Prognostic evaluation of oestrogen-regulated protein immunoreactivity in ductal invasive (NOS) breast cancer.
Prognostic implications of carboxyl-terminus of Hsc70 interacting protein and lysyl-oxidase expression in human breast cancer.
Prognostic significance of GRP78 expression patterns in breast cancer patients receiving adjuvant chemotherapy.
Prognostic significance of heat shock protein 90AA1 (HSP90?) in invasive breast cancer.
Progression of the role of CRYAB in signaling pathways and cancers.
Proliferating cell nuclear antigen and heat shock protein 70 immunolocalization in invasive ductal breast cancer not otherwise specified.
Proteomic characterization of differentially expressed proteins in breast cancer: Expression of hnRNP H1, RKIP and GRP78 is strongly associated with HER-2/neu status.
Proteomic detection of changes in protein synthesis induced by fibroblast growth factor-2 in MCF-7 human breast cancer cells.
Proteomic identification of heat shock protein 90 as a candidate target for p53 mutation reactivation by PRIMA-1 in breast cancer cells.
Proteomics of breast cancer for marker discovery and signal pathway profiling.
Proteomics of breast cancer: outcomes and prospects.
Proteomics-based identification of HSP60 as a tumor-associated antigen in early stage breast cancer and ductal carcinoma in situ.
PTHrP [67-86] regulates the expression of stress proteins in breast cancer cells inducing modifications in urokinase-plasminogen activator and MMP-1 expression.
Purification and characterisation of the breast cancer metastasis suppressor, BRMS1.
Quercetin inhibits heat shock protein induction but not heat shock factor DNA-binding in human breast carcinoma cells.
Quinazoline Based HSP90 Inhibitors: Synthesis, Modeling Study and ADME Calculations Towards Breast Cancer Targeting.
Radiofrequency hyperthermia promotes the therapeutic effects on chemotherapeutic-resistant breast cancer when combined with heat shock protein promoter-controlled HSV-TK gene therapy: Toward imaging-guided interventional gene therapy.
Radiosynthesis, biological evaluation and preliminary microPET study of 18F-labeled 5-resorcinolic triazolone derivative based on ganetespib targeting HSP90.
Ratio of proliferation markers and HSP90 gene expression as a predictor of pathological complete response in breast cancer neoadjuvant chemotherapy.
Recent advances in systemic therapy: Advances in systemic therapy for HER2-positive metastatic breast cancer.
Recent trends in microRNA research into breast cancer with particular focus on the associations between microRNAs and intrinsic subtypes.
Regulation of alphaB-crystallin gene expression by the transcription factor Ets1 in breast cancer.
Regulation of heat shock protein 72 kDa and 90 kDa in human breast cancer MDA-MB-231 cells.
Relationship Between HSP70 and ERBB2 Expression in Breast Cancer Cell Lines Regarding Drug Resistance.
Relationship between the expression of phosphorylated heat shock protein beta-1 with lymph node metastases of breast cancer.
Research resource: enhanced genome-wide occupancy of estrogen receptor ? by the cochaperone p23 in breast cancer cells.
Response of human breast cancer cells to heat shock and chemotherapeutic drugs.
Role of BRCA1 in heat shock response.
Role of estrogen receptor/Sp1 complexes in estrogen-induced heat shock protein 27 gene expression.
Role of GRP78 in promoting therapeutic-resistant breast cancer.
Role of HSP90 in mediating cross-talk between the estrogen receptor and the Ah receptor signal transduction pathways.
Search for Hsp90 Inhibitors with Potential Anticancer Activity: Isolation and SAR Studies of Radicicol and Monocillin I from Two Plant-Associated Fungi of the Sonoran Desert(1).
Selective depletion of heat shock protein 70 (Hsp70) activates a tumor-specific death program that is independent of caspases and bypasses Bcl-2.
Sensitivity of flow cytometric assay for measurement of human intracellular heat shock protein 27.
Sensitization of multidrug-resistant human cancer cells to Hsp90 inhibitors by down-regulation of SIRT1.
Serological detection of heat shock protein hsp27 in normal and breast cancer patients.
Serum antibodies to the 27-kd heat shock protein in women with gynecologic cancers.
Short peptides derived from the BAG-1 C-terminus inhibit the interaction between BAG-1 and HSC70 and decrease breast cancer cell growth.
Short-hairpin RNA-mediated Heat shock protein 90 gene silencing inhibits human breast cancer cell growth in vitro and in vivo.
Silencing the hsp25 gene eliminates migration capability of the highly metastatic murine 4T1 breast adenocarcinoma cell.
Simultaneous quantification of protein phosphorylation sites using liquid chromatography-tandem mass spectrometry-based targeted proteomics: a linear algebra approach for isobaric phosphopeptides.
SMR peptide antagonizes mortalin promoted release of extracellular vesicles and affects mortalin protection from complement-dependent cytotoxicity in breast cancer cells and leukemia cells.
Spontaneous and controllable activation of suicide gene expression driven by the stress-inducible grp78 promoter resulting in eradication of sizable human tumors.
Stat3 modulates heat shock 27kDa protein expression in breast epithelial cells.
Stereospecific antitumor activity of radicicol oxime derivatives.
Stress chaperone mortalin contributes to epithelial-mesenchymal transition and cancer metastasis.
Structural insights into tumor-specific chaperoning activity of gamma synuclein in protecting estrogen receptor alpha 36 and its role in tamoxifen resistance in breast cancer.
Structure-Activity Relationships of Benzothiazole-Based Hsp90 C-Terminal-Domain Inhibitors.
Suppression of heat shock protein 27 induces long-term dormancy in human breast cancer.
Suppression of inflammatory cascade is implicated in methyl amooranin-mediated inhibition of experimental mammary carcinogenesis.
Synergetic cytotoxic activity toward breast cancer cells enhanced by the combination of Antp-TPR hybrid peptide targeting Hsp90 and Hsp70-targeted peptide.
Synergistic Activity of the HSP90 Inhibitor Ganetespib With Lapatinib Reverses Acquired Lapatinib Resistance in HER2-Positive Breast Cancer Cells.
Synergistic promotion of breast cancer cells death by targeting molecular chaperone GRP78 and heat shock protein 70.
Synthesis and biological activity of simplified denoviose-coumarins related to novobiocin as potent inhibitors of heat-shock protein 90 (hsp90).
Synthesis of 19-substituted geldanamycins with altered conformations and their binding to heat shock protein Hsp90.
Synthesis of novel dual target inhibitors of PARP and HSP90 and their antitumor activities.
Systematic analyses of key genes and pathways in the development of invasive breast cancer.
Systematic Proteomic Identification of the Heat Shock Proteins (Hsp) that Interact with Estrogen Receptor Alpha (ER?) and Biochemical Characterization of the ER?-Hsp70 Interaction.
Tamoxifen-induced cytotoxicity in breast cancer cells is mediated by glucose-regulated protein 78 (GRP78) via AKT (Thr308) regulation.
Targeted inhibition of Hsp90 by ganetespib is effective across a broad spectrum of breast cancer subtypes.
Targeted Therapies in Breast Cancer: Implications for Advanced Oncology Practice.
Targeted therapy for breast cancer.
Targeting GRP78 and antiestrogen resistance in breast cancer.
Targeting highly expressed extracellular HSP90 in breast cancer stem cells inhibits tumor growth in vitro and in vivo.
Targeting HSP90 Gene Expression with 17-DMAG Nanoparticles in Breast Cancer Cells.
Targeting Hsp90 prevents escape of breast cancer cells from tyrosine kinase inhibition.
Targeting Mortalin by Embelin Causes Activation of Tumor Suppressor p53 and Deactivation of Metastatic Signaling in Human Breast Cancer Cells.
Targeting on glycosylation of mutant FLT3 in acute myeloid leukemia.
Targeting the hsp70 gene delays mammary tumor initiation and inhibits tumor cell metastasis.
The antitumor natural product tanshinone IIA inhibits protein kinase C and acts synergistically with 17-AAG.
The c-Yes 3'-UTR contains adenine/uridine-rich elements that bind AUF1 and HuR involved in mRNA decay in breast cancer cells.
The clinicopathological significance of Mortalin overexpression in invasive ductal carcinoma of breast.
The COOH-Terminal Proline-Rich Region of GRP78 Is a Key Regulator of Its Cell Surface Expression and Viability of Tamoxifen-Resistant Breast Cancer Cells.
The design, synthesis, and evaluation of coumarin ring derivatives of the novobiocin scaffold that exhibit antiproliferative activity.
The deubiquitylase USP2 maintains ErbB2 abundance via counteracting endocytic degradation and represents a therapeutic target in ErbB2-positive breast cancer.
The effects of Hsp90 expression alteration on spinal metastases of breast carcinoma.
The emergence of targeted drugs in breast cancer to prevent resistance to endocrine treatment and chemotherapy.
The endoplasmic reticulum stress markers GRP78 and CHOP predict disease-free survival and responsiveness to chemotherapy in breast cancer.
The flavonoid TL-2-8 induces cell death and immature mitophagy in breast cancer cells via abrogating the function of the AHA1/Hsp90 complex.
The heat shock protein 90 inhibitor geldanamycin and the ErbB inhibitor ZD1839 promote rapid PP1 phosphatase-dependent inactivation of AKT in ErbB2 overexpressing breast cancer cells.
The heat shock protein 90 inhibitor, 17-allylamino-17-demethoxygeldanamycin, enhances osteoclast formation and potentiates bone metastasis of a human breast cancer cell line.
The HSP-RTK-Akt axis mediates acquired resistance to Ganetespib in HER2-positive breast cancer.
The HSP90 inhibitor NVP-AUY922 inhibits growth of HER2 positive and trastuzumab-resistant breast cancer cells.
The in vitro immunogenic potential of caspase-3 proficient breast cancer cells with basal low immunogenicity is increased by hypofractionated irradiation.
The induction of heme oxygenase-1 suppresses heat shock protein 90 and the proliferation of human breast cancer cells through its byproduct carbon monoxide.
The non-DNA-binding heterooligomeric form of mammalian steroid hormone receptors contains a hsp90-bound 59-kilodalton protein.
The overexpression of Hsp90B1 is associated with tumorigenesis of canine mammary glands.
The phosphorylation-specific association of STMN1 with GRP78 promotes breast cancer metastasis.
The potential role of HSP70 as an indicator of response to radiation and hyperthermia treatments for recurrent breast cancer.
The Prognostic Significance of Hsp70/Hsp90 Expression in Breast Cancer: A Systematic Review and Meta-analysis.
The small heat shock protein B8 (HSPB8) modulates proliferation and migration of breast cancer cells.
The small heat shock protein hsp27 increases invasiveness but decreases motility of breast cancer cells.
The small heat shock protein hsp27 is correlated with growth and drug resistance in human breast cancer cell lines.
The small heat shock protein HSP27 is not an independent prognostic marker in axillary lymph node-negative breast cancer patients.
Tid1, CHIP and ErbB2 interactions and their prognostic implications for breast cancer patients.
Tissue microarray analysis of FAS, Bcl-2, Bcl-x, ER, PgR, Hsp60, p53 and Her2-neu in breast carcinoma.
Tomm34 is commonly expressed in epithelial ovarian cancer and associates with tumour type and high FIGO stage.
Towards a transcriptome-based theranostic platform for unfavorable breast cancer phenotypes.
Treatment with panobinostat induces glucose-regulated protein 78 acetylation and endoplasmic reticulum stress in breast cancer cells.
Triple-negative breast cancer: novel therapies and new directions.
Tumor-Intrinsic and Tumor-Extrinsic Factors Impacting Hsp90-Targeted Therapy.
Tunicamycin-induced ER stress in breast cancer cells neither expresses GRP78 on the surface nor secretes it into the media.
UBR1 promotes protein kinase quality control and sensitizes cells to Hsp90 inhibition.
Understanding the sources of errors in ex vivo Hsp90 molecular imaging for rapid-on-site breast cancer diagnosis.
Up-regulation of cathepsin S expression by HSP90 and 5-HT7 receptor-dependent serotonin signaling correlates with triple negativity of human breast cancer.
Upregulation of mortalin/mthsp70/Grp75 contributes to human carcinogenesis.
Using a xenograft model of human breast cancer metastasis to find genes associated with clinically aggressive disease.
USP22-dependent HSP90AB1 expression promotes resistance to HSP90 inhibition in mammary and colorectal cancer.
Vascular targeting and antiangiogenesis agents induce drug resistance effector GRP78 within the tumor microenvironment.
VIP-grafted sterically stabilized phospholipid nanomicellar 17-allylamino-17-demethoxy geldanamycin: a novel targeted nanomedicine for breast cancer.
Visualising dual downregulation of insulin-like growth factor receptor-1 and vascular endothelial growth factor-A by heat shock protein 90 inhibition effect in triple negative breast cancer.
Visualizing and Quantifying the Effect of the Inhibition of HSP70 on Breast Cancer Cells Based on Laser Scanning Microscopy.
Why Is This Effective HSP90 Inhibitor Not Being Developed in HER2+ Breast Cancer?
Withanolides-induced breast cancer cell death is correlated with their ability to inhibit heat protein 90.
X-linked inhibitor of apoptosis protein (XIAP) is a client of heat shock protein 70 (Hsp70) and a biomarker of its inhibition.
[Diagnostic and Therapeutic Potential of Membrane HSP90].
[Effect of anacardic acid, a Hsp90 inhibitor, on proliferation, invasion and migration of breast cancer MDA-MB-231 cells].
[Effect of HSP90 function inhibited on the telomerase and P53 mutant in breast cancer cells]
[Impact of HSP90 Inhibition on Viability and Cell Cycle in Relation to p53 Status].
[Preliminary study of effect of antisense hsc70 effect on the stability of mutant p53 protein]
[The role of the heat shock protein in human breast cancer]
Bronchiolitis
Lack of protection in mice and necrotizing bronchointerstitial pneumonia with bronchiolitis in guinea pigs immunized with vaccines directed against the hsp60 molecule of Mycobacterium tuberculosis.
Bronchiolitis Obliterans
Involvement of collagen-binding heat shock protein 47 and procollagen type I synthesis in idiopathic pulmonary fibrosis: contribution of type II pneumocytes to fibrosis.
The role of heat shock protein 27 in bronchiolitis obliterans syndrome after lung transplantation.
Bronchitis
Heat shock protein 70 in lung and kidney of specific-pathogen-free chickens is a receptor-associated protein that interacts with the binding domain of the spike protein of infectious bronchitis virus.
Heat Shock Protein Member 8 Is an Attachment Factor for Infectious Bronchitis Virus.
Bronchitis, Chronic
Glucocorticoid receptors in bronchial epithelial cells in asthma.
Heat shock proteins mRNA expressions by peripheral blood mononuclear cells in asthma and chronic bronchitis.
Increased expression of heat shock protein 70 on airway cells in asthma and chronic bronchitis.
Bronchopulmonary Dysplasia
Heat Shock Protein-70 Levels Are Associated With a State of Oxidative Damage in the Development of Bronchopulmonary Dysplasia.
Treatment with Geranylgeranylacetone Induces Heat Shock Protein 70 and Attenuates Neonatal Hyperoxic Lung Injury in a Model of Bronchopulmonary Dysplasia.
[Effect of glucose regulated protein 78 gene silencing on hyperoxia-induced apoptosis in alveolar epithelial cells].
Brucellosis
Cellular prion protein promotes Brucella infection into macrophages.
Characterization of the main immunogenic proteins in Brucella infection for their application in diagnosis of brucellosis.
Comparison of heat shock response in Brucella abortus and Brucella melitensis.
Immunoblot studies in the differential diagnosis of porcine brucellosis: an immunodominant 62 kDa protein is related to the mycobacterial 65 kDa heat shock protein (HSP-65).
Molecular cloning and nucleotide sequence analysis of the gene encoding the immunoreactive Brucella abortus Hsp60 protein, BA60K.
Role of immune responses to a GroEL heat shock protein in preventing brucellosis in mice vaccinated with Brucella abortus strain RB51.
Bulbo-Spinal Atrophy, X-Linked
17-AAG, an Hsp90 inhibitor, ameliorates polyglutamine-mediated motor neuron degeneration.
17-DMAG ameliorates polyglutamine-mediated motor neuron degeneration through well-preserved proteasome function in an SBMA model mouse.
Alleviating neurodegeneration by an anticancer agent: an Hsp90 inhibitor (17-AAG).
Heat shock protein 70 chaperone overexpression ameliorates phenotypes of the spinal and bulbar muscular atrophy transgenic mouse model by reducing nuclear-localized mutant androgen receptor protein.
Hsp40 molecules that target to the ubiquitin-proteasome system decrease inclusion formation in models of polyglutamine disease.
Hsp40 Molecules That Target to the Ubiquitin-proteasome System Decrease Inclusion Formation in Models of Polyglutamine Disease.
Inhibition of Hsp70 by methylene blue affects signaling protein function and ubiquitination and modulates polyglutamine protein degradation.
Targeting Hsp90/Hsp70-based protein quality control for treatment of adult onset neurodegenerative diseases.
Trehalose induces autophagy via lysosomal-mediated TFEB activation in models of motoneuron degeneration.
Burkitt Lymphoma
Expression of heat-shock protein-90 in non-Hodgkin's lymphomas.
Heat shock protein 70 (Hsp70)-stimulated deoxycytidine deaminases from a human lymphoma cell but not the activation-induced cytidine deaminase (AID) from Ramos 6.4 human Burkitt's lymphoma cells.
HSP90 promotes Burkitt lymphoma cell survival by maintaining tonic B-cell receptor signaling.
Human peripheral gamma delta T cells recognize hsp60 molecules on Daudi Burkitt's lymphoma cells.
Immunoelectron microscopic localization of the 60-kDa heat shock chaperonin protein (Hsp60) in mammalian cells.
Inhibition of Hsp90 Suppresses PI3K/AKT/mTOR Signaling and Has Antitumor Activity in Burkitt Lymphoma.
Recognition by human V gamma 9/V delta 2 T cells of a GroEL homolog on Daudi Burkitt's lymphoma cells.
Targeting the MYC Oncogene in Burkitt Lymphoma through HSP90 Inhibition.
Buruli Ulcer
Sero-epidemiology as a tool to screen populations for exposure to Mycobacterium ulcerans.
Caliciviridae Infections
Molecular chaperone Hsp90 is a therapeutic target for noroviruses.
Candidiasis
A 70-kilodalton recombinant heat shock protein of Candida albicans is highly immunogenic and enhances systemic murine candidiasis.
Acquired immunity to systemic candidiasis in immunodeficient mice: role of antibody to heat-shock protein 90.
Antibodies against Candida: potential therapeutics?
Antifungal antibodies: a new approach to the treatment of systemic candidiasis.
Chitosan hydrogel loaded with recombinant protein containing epitope C from HSP90 of Candida albicans induces protective immune responses against systemic candidiasis.
Circulating heat shock proteins in women with a history of recurrent vulvovaginitis.
Comparison of protective effect of protein and DNA vaccines hsp90 in murine model of systemic candidiasis.
COVID19 associated mucormycosis: Is GRP78 a possible link?
Differential Gene Expression of Heat Shock Protein 90 (Hsp90) of Candida albicans obtained from Malaysian and Iranian Patients.
Direct effects of non-antifungal agents used in cancer chemotherapy and organ transplantation on the development and virulence of Candida and Aspergillus species.
Dose range evaluation of Mycograb C28Y variant, a human recombinant antibody fragment to heat shock protein 90, in combination with amphotericin B-desoxycholate for treatment of murine systemic candidiasis.
Genetically recombinant antibodies: new therapeutics against candidiasis.
Harnessing Hsp90 function as a powerful, broadly effective therapeutic strategy for fungal infectious disease.
Hsp90 governs echinocandin resistance in the pathogenic yeast Candida albicans via calcineurin.
Metallochelating liposomes with associated lipophilised norAbuMDP as biocompatible platform for construction of vaccines with recombinant His-tagged antigens: Preparation, structural study and immune response towards rHsp90.
Preliminary assessment of a human recombinant antibody fragment to hsp90 in murine invasive candidiasis.
Production of antibodies to antigens of Candida albicans in CBA/H mice.
Protective immune responses against systemic candidiasis mediated by phage-displayed specific epitope of Candida albicans heat shock protein 90 in C57BL/6J mice.
Systemic and mucosal immunization with Candida albicans hsp90 elicits hsp90-specific humoral response in vaginal mucosa which is further enhanced during experimental vaginal candidiasis.
The non-Geldanamycin Hsp90 inhibitors enhanced the antifungal activity of fluconazole.
The use of hybrid phage displaying antigen epitope and recombinant protein in the diagnosis of systemic Candida albicans infection in rabbits and cancer patients.
Candidiasis, Invasive
A Randomized, Blinded, Multicenter Trial of Lipid-Associated Amphotericin B Alone versus in Combination with an Antibody-Based Inhibitor of Heat Shock Protein 90 in Patients with Invasive Candidiasis.
An antibody reactivity-based assay for diagnosis of invasive candidiasis using protein array.
Efungumab and caspofungin: pre-clinical data supporting synergy.
Efungumab: A Novel Agent in the Treatment of Invasive Candidiasis (November).
Fungal antigens expressed during invasive aspergillosis.
Potential of anti-Candida antibodies in immunoprophylaxis.
Preclinical assessment of the efficacy of mycograb, a human recombinant antibody against fungal HSP90.
Preliminary assessment of a human recombinant antibody fragment to hsp90 in murine invasive candidiasis.
Prophylactic vaccination with phage-displayed epitope of C. albicans elicits protective immune responses against systemic candidiasis in C57BL/6 mice.
Recombinant antibodies: a natural partner in combinatorial antifungal therapy.
Serum antibody signature directed against Candida albicans Hsp90 and enolase detects invasive candidiasis in non-neutropenic patients.
The use of hybrid phage displaying antigen epitope and recombinant protein in the diagnosis of systemic Candida albicans infection in rabbits and cancer patients.
Capsule Opacification
HSP90 as a novel therapeutic target for posterior capsule opacification.
Carcinogenesis
(1)H, (15)N and (13)C backbone resonance assignments of the TPR1 and TPR2A domains of mouse STI1.
17-AAG: mechanisms of antitumour activity.
17-Allylamino-17-demethoxygeldanamycin (17-AAG) is effective in down-regulating mutated, constitutively activated KIT protein in human mast cells.
17-DMAG induces heat shock protein 90 functional impairment in human bladder cancer cells: knocking down the hallmark traits of malignancy.
60KDa chaperonin (HSP60) is over-expressed during colorectal carcinogenesis.
A fluorescence polarization assay for inhibitors of Hsp90.
A Mechanistic and Structural Analysis of the Inhibition of Heat Shock Protein 90 by the Benzoquinone and Hydroquinone Ansamycins.
A novel DNA vaccine constructed by heat shock protein 70 and melanoma antigen-encoding gene 3 against tumorigenesis.
A potential role for Helicobacter pylori heat shock protein 60 in gastric tumorigenesis.
Acetylation of androgen receptor by ARD1 promotes dissociation from HSP90 complex and prostate tumorigenesis.
Activated tyrosine kinase Ack1 promotes prostate tumorigenesis: role of Ack1 in polyubiquitination of tumor suppressor Wwox.
Activation of the unfolded protein response contributes toward the antitumor activity of vorinostat.
Acute acidification or amiloride treatment suppresses the ability of Hsp70 to inhibit heat-induced apoptosis.
Altered Hsp90 function in cancer: a unique therapeutic opportunity.
Androgen Receptor Protein Levels Are Significantly Reduced in Serous Ovarian Carcinomas Compared with Benign or Borderline Disease but Are Not altered by Cancer Stage or Metastatic Progression.
Androgen receptor signaling in hepatocellular carcinoma and pancreatic cancers.
Anti-cancer therapeutic approaches based on intracellular and extracellular heat shock proteins.
Anti-HIV agent MAP30 modulates the expression profile of viral and cellular genes for proliferation and apoptosis in AIDS-related lymphoma cells infected with Kaposi's sarcoma-associated virus.
Anti-Inflammatory Mechanism Involved in Pomegranate-Mediated Prevention of Breast Cancer: the Role of NF-?B and Nrf2 Signaling Pathways.
Anticancer activity of Celastrol in combination with ErbB2-targeted therapeutics for treatment of ErbB2-overexpressing breast cancers.
Anticancer activity of methylene blue via inhibition of heat shock protein 70.
Antitumor agents 295. E-ring hydroxylated antofine and cryptopleurine analogues as antiproliferative agents: design, synthesis, and mechanistic studies.
Association between Alpha B-crystallin expression and prognosis in patients with solid tumors: A protocol for systematic review and meta-analysis.
AT-533, a novel Hsp90 inhibitor, inhibits breast cancer growth and HIF-1?/VEGF/VEGFR-2-mediated angiogenesis in vitro and in vivo.
ATM is the primary kinase responsible for phosphorylation of Hsp90? after ionizing radiation.
ATP-dependent simian virus 40 T-antigen-Hsc70 complex formation.
Blockage of HSP 90 modulates Helicobacter pylori-induced IL-8 productions through the inactivation of transcriptional factors of AP-1 and NF-kappaB.
Calpain Genetic Disruption and HSP90 Inhibition Combine To Attenuate Mammary Tumorigenesis.
Can The Lack of HSP90alpha Protein in Brain Normal Tissue and Cell Lines, Rationalise it as a Possible Therapeutic Target for Gliomas?
CD1A-positive cells and HSP60 (HSPD1) levels in keratoacanthoma and squamous cell carcinoma.
Cell surface expression of 78-kDa glucose-regulated protein (GRP78) mediates diabetic nephropathy.
Cell surface GRP78 promotes stemness in normal and neoplastic cells.
Chaperone-dependent stabilization and degradation of p53 mutants.
Characterization and prognostic significance of mortalin, Bcl-2 and Bax in intrahepatic cholangiocarcinoma.
Chemogenomic screening identifies the Hsp70 co-chaperone DNAJA1 as a hub for anticancer drug resistance.
Combinatorial attack on multistep oncogenesis by inhibiting the Hsp90 molecular chaperone.
Comparative analysis of Hsp10 and Hsp90 expression in healthy mucosa and adenocarcinoma of the large bowel.
Cripto haploinsufficiency affects in vivo colon tumor development.
Cripto stabilizes GRP78 on the cell membrane.
Cytoplasmic expression of pontin in renal cell carcinoma correlates with tumor invasion, metastasis and patients' survival.
Decreased expression of heat shock protein 20 in colorectal cancer and its implication in tumorigenesis.
Detecting Posttranslational Modifications of Hsp90.
Development and molecular characterization of HCT-116 cell lines resistant to the tumor promoter and multiple stress-inducer, deoxycholate.
Development of pyrazolo[3,4-d]pyrimidine-6-amine-based TRAP1 inhibitors that demonstrate in vivo anticancer activity in mouse xenograft models.
Different immunohistochemical levels of Hsp60 and Hsp70 in a subset of brain tumors and putative role of Hsp60 in neuroepithelial tumorigenesis.
Differential expression of heat shock protein 90 isoforms in small cell lung cancer.
Differential expression of hsp90, gelsolin and gst-pi in human gastric-carcinoma cell-lines.
Dihydroquinone ansamycins: toward resolving the conflict between low in vitro affinity and high cellular potency of geldanamycin derivatives.
Direct targeting of HSP90 with daurisoline destabilizes ?-catenin to suppress lung cancer tumorigenesis.
Discorhabdin N, a South African Natural Compound, for Hsp72 and Hsc70 Allosteric Modulation: Combined Study of Molecular Modeling and Dynamic Residue Network Analysis.
Discovery of benzamide tetrahydro-4H-carbazol-4-ones as novel small molecule inhibitors of Hsp90.
Docosahexaenoic Acid-mediated Inhibition of Heat Shock Protein 90-p23 Chaperone Complex and Downstream Client Proteins in Lung and Breast Cancer.
Down-regulation of HSP60 Suppresses the Proliferation of Glioblastoma Cells via the ROS/AMPK/mTOR Pathway.
Downregulation of HSP60 disrupts mitochondrial proteostasis to promote tumorigenesis and progression in clear cell renal cell carcinoma.
Downregulation of the tumor suppressor HSPB7, involved in the p53 pathway, in renal cell carcinoma by hypermethylation.
Doxorubicin anti-tumor mechanisms include Hsp60 post-translational modifications leading to the Hsp60/p53 complex dissociation and instauration of replicative senescence.
Druggability of Mortalin for Cancer and Neuro-Degenerative Disorders.
Dual role of heat shock proteins as regulators of apoptosis and innate immunity.
Dual targeting of HSC70 and HSP72 inhibits HSP90 function and induces tumor-specific apoptosis.
Effects of a Unique Combination of the Whole-Body Low Dose Radiotherapy with Inactivation of Two Immune Checkpoints and/or a Heat Shock Protein on the Transplantable Lung Cancer in Mice.
Endoplasmic reticulum chaperone GRP78/BiP is critical for mutant Kras-driven lung tumorigenesis.
Endoplasmic reticulum heat shock protein gp96 maintains liver homeostasis and promotes hepatocellular carcinogenesis.
Esophageal cancer alters the expression of nuclear pore complex binding protein Hsc70 and eIF5A-1.
Estrogen receptor-?36-mediated rapid estrogen signaling regulates 78 kDa glucose-regulated protein expression in gastric carcinoma cells.
Exploiting the HSP60/10 chaperonin system as a chemotherapeutic target for colorectal cancer.
Expression of 60-kD heat shock protein increases during carcinogenesis in the uterine exocervix.
Expression of autophagy and ER stress-related proteins in primary salivary adenoid cystic carcinoma.
Expression of ER stress and autophagy-related molecules in human non-small cell lung cancer and premalignant lesions.
Expression of heat shock protein 60 kDa is upregulated in cervical cancer.
Expression of heat shock protein70 in oral submucous fibrosis and oral squamous cell carcinoma: an immunohistochemical study.
Expression of heat shock proteins in premalignant and malignant urothelial lesions of bovine urinary bladder.
Expression of Hsp90 chaperome proteins in human tumor tissue.
Expression of mortalin detected in human liver cancer by tissue microarrays.
Expressions of GRP78 and Bax associate with differentiation, metastasis, and apoptosis in non-small cell lung cancer.
Functional role of Hsp60 as a positive regulator of human viral infection progression.
Ganetespib and HSP90: Translating Preclinical Hypotheses into Clinical Promise.
Geldanamycin administration reduces the amount of primordial germ cells in the mouse embryo.
Geldanamycin and its anti-cancer activities.
Geldanamycin-Induced PCNA Degradation in Isolated Hsp90 Complex from Cancer Cells.
Gene expression pattern in canine mammary osteosarcoma.
Gene Expression Signature-Based Approach Identifies Antifungal Drug Ciclopirox As a Novel Inhibitor of HMGA2 in Colorectal Cancer.
Germ cell-specific heat shock protein 70-2 is expressed in cervical carcinoma and is involved in the growth, migration, and invasion of cervical cells.
Glucose-regulated protein 78 (GRP78) as a potential novel biomarker and therapeutic target in multiple myeloma.
Glucose-regulated protein 78 contributes to the proliferation and tumorigenesis of human colorectal carcinoma via AKT and ERK pathways.
Gonadal apoptosis during sex reversal of the rice field eel: implications for an evolutionarily conserved role of the molecular chaperone heat shock protein 10.
Grp78 as a therapeutic target for refractory head-neck cancer with CD24(-)CD44(+) stemness phenotype.
GRP78 haploinsufficiency suppresses acinar-to-ductal metaplasia, signaling, and mutant Kras-driven pancreatic tumorigenesis in mice.
GRP78 in lung cancer.
GRP78 positively regulates estrogen?stimulated cell growth mediated by ER??36 in gastric cancer cells.
HDAC6: Physiological function and its selective inhibitors for cancer treatment.
Heat Shock Protein 27 as a New Therapeutic Target for Radiation Sensitization of Head and Neck Squamous Cell Carcinoma.
Heat Shock Protein 27 Expression is Inversely Correlated with Atrophic Gastritis and Intraepithelial Neoplasia.
Heat Shock Protein 90 Inhibition in Cancer Drug Discovery: From Chemistry to Futural Clinical Applications.
Heat shock protein 90 inhibitor NVP-AUY922 exerts potent activity against adult T-cell leukemia-lymphoma cells.
Heat shock protein 90 inhibitors suppress aryl hydrocarbon receptor-mediated activation of CYP1A1 and CYP1B1 transcription and DNA adduct formation.
Heat Shock Protein 90 Is a Potential Therapeutic Target in Cholangiocarcinoma.
Heat Shock Protein 90 is Associated with Hyperplasia and Neoplastic Transformation of Canine Prostatic Epithelial Cells.
Heat shock protein 90 is involved in the regulation of HMGA2-driven growth and epithelial-to-mesenchymal transition of colorectal cancer cells.
Heat Shock Protein 90 Regulates Subcellular Localization of Smads in Mv1Lu Cells.
Heat shock protein 90 stabilizes nucleolin to increase mRNA stability in mitosis.
Heat shock protein expression in canine malignant mammary tumours.
Heat shock protein Hsp72 plays an essential role in Her2-induced mammary tumorigenesis.
Heat shock protein90 in lobular neoplasia of the breast.
Heat shock proteins and cancer: intracellular chaperones or extracellular signalling ligands?
Heat shock proteins stimulate APOBEC-3-mediated cytidine deamination in the hepatitis B virus.
Heat-shock protein 90 inhibitors in antineoplastic therapy: is it all wrapped up?
Helicobacter pylori heat shock protein 60 antibodies are associated with gastric cancer.
Helicobacter pylori-derived heat shock protein 60 increases the induction of regulatory T-cells associated with persistent infection.
Hexavalent chromium, a lung carcinogen, confers resistance to thermal stress and interferes with heat shock protein expression in human bronchial epithelial cells.
Highlights in experimental therapeutics.
HMGN5 promotes IL-6-induced epithelial-mesenchymal transition of bladder cancer by interacting with Hsp27.
Hsp27 and Hsp60 in human submandibular salivary gland: Quantitative patterns in healthy and cancerous tissues with potential implications for differential diagnosis and carcinogenesis.
Hsp60 and Hsp10 down-regulation predicts bronchial epithelial carcinogenesis in smokers with chronic obstructive pulmonary disease.
HSP60 as a drug target.
HSP60 expression during carcinogenesis: a molecular "proteus" of carcinogenesis?
HSP60 expression during carcinogenesis: where is the pilot?
HSP60 in cancer: a promising biomarker for diagnosis and a potentially useful target for treatment.
Hsp60: molecular anatomy and role in colorectal cancer diagnosis and treatment.
HSP70 and ER expression in cervical intraepithelial neoplasia and cervical cancer.
HSP90 and Co-chaperones: Impact on Tumor Progression and Prospects for Molecular-Targeted Cancer Therapy.
Hsp90 in Cancer: Transcriptional Roles in the Nucleus.
Hsp90 in the continuum of breast ductal carcinogenesis: Evaluation in precursors, preinvasive and ductal carcinoma lesions.
HSP90 Inhibition Suppresses PGE2 Production via Modulating COX-2 and 15-PGDH Expression in HT-29 Colorectal Cancer Cells.
Hsp90 inhibitor can inhibit UV carcinogenesis.
Hsp90 inhibitor geldanamycin and its derivatives as novel cancer chemotherapeutic agents.
Hsp90 Is Essential for Chl1-Mediated Chromosome Segregation and Sister Chromatid Cohesion.
HSP90 Molecular Chaperones, Metabolic Rewiring, and Epigenetics: Impact on Tumor Progression and Perspective for Anticancer Therapy.
Identification and characterization of molecular interactions between mortalin/mtHsp70 and HSP60.
Identification and Characterization of MortaparibPlus-A Novel Triazole Derivative That Targets Mortalin-p53 Interaction and Inhibits Cancer-Cell Proliferation by Wild-Type p53-Dependent and -Independent Mechanisms.
Identification and functional characterization of nuclear mortalin in human carcinogenesis.
Identification of the Differential Expression Profiles of Serum and Tissue Proteins During Rat Hepatocarcinogenesis.
Identification of the role of mono-ADP-ribosylation in colorectal cancer by integrated transcriptome analysis.
Immune chaperone gp96 drives the contributions of macrophages to inflammatory colon tumorigenesis.
Immunohistochemical evaluation of expression of heat shock proteins HSP70 and HSP90 in mammary gland neoplasms in bitches.
Immunohistochemical evaluation of PCNA, p53, HSP60, HSP10 and MUC-2 presence and expression in prostate carcinogenesis.
Immunohistochemical tumour markers in endometrial carcinoma.
Immunomorphological Pattern of Molecular Chaperones in Normal and Pathological Thyroid Tissues and Circulating Exosomes: Potential Use in Clinics.
Improvement of inhibitor identification for heat shock protein 90? by utilizing a red-shifted fluorescence polarization probe.
In silico design novel Vibsanin B derivatives as inhibitor for heat shock protein 90 based on 3D-QSAR, molecular docking and molecular dynamics simulation.
In Vivo Suppression of Heat Shock Protein (HSP)27 and HSP70 Accelerates DMBA-Induced Skin Carcinogenesis by Inducing Antigenic Unresponsiveness to the Initiating Carcinogenic Chemical.
Increased HSP27 correlates with malignant biological behavior of non-small cell lung cancer and predicts patient's survival.
Induction of apoptosis by abrogation of HSP70 expression in human oral cancer cells.
Inhibition of Hsp90 via 17-DMAG induces apoptosis in a p53-dependent manner to prevent medulloblastoma.
Inhibition of the mitochondrial Hsp90 chaperone network: A novel, efficient treatment strategy for cancer?
Innate immunity meets with cellular stress at the IKK complex: Regulation of the IKK complex by HSP70 and HSP90.
Integration of microRNAome, proteomics and metabolomics to analyze arsenic-induced malignant cell transformation.
Interaction between GRP78 and IGFBP-3 Affects Tumourigenesis and Prognosis in Breast Cancer Patients.
Interactions between Hsp90 and oncogenic viruses: implications for viral cancer therapeutics.
Investigation of anticancer activities of STA-9090 (ganetespib) as a second generation HSP90 inhibitor in Saos-2 osteosarcoma cells.
In Vivo Conformational Dynamics of Hsp90 and Its Interactors.
Is Mongolian gerbil really adequate host animal for study of Helicobacter pylori infection-induced gastritis and cancer?
Landscape of the mitochondrial Hsp90 metabolome in tumours.
Luteolin induces carcinoma cell apoptosis through binding Hsp90 to suppress constitutive activation of STAT3.
Malignant transformation of NIH3T3 cells by overexpression of mot-2 protein.
Maximizing the Therapeutic Potential of Hsp90 Inhibitors.
Membrane HSP70: the molecule triggering gammadelta T cells in the early stage of tumorigenesis.
Mimotope-hormesis and mortalin/grp75/mthsp70: a new hypothesis on how infectious disease-associated epitope mimicry may explain low cancer burden in developing nations.
miR-30d, miR-181a and miR-199a-5p cooperatively suppress the endoplasmic reticulum chaperone and signaling regulator GRP78 in cancer.
Molecular Chaperone GRP94/GP96 in Cancers: Oncogenesis and Therapeutic Target.
Molecular characterization of hsp90 isoforms in colorectal cancer cells and its association with tumour progression.
Molecular genetics of the aip gene in familial pituitary tumorigenesis.
Mortalin expression in pancreatic cancer and its clinical and prognostic significance.
Mortalin maintains breast cancer stem cells stemness via activation of Wnt/GSK3?/?-catenin signaling pathway.
Mortalin overexpression predicts poor prognosis in early stage of non-small cell lung cancer.
Mortalin promotes cell proliferation and epithelial mesenchymal transition of intrahepatic cholangiocarcinoma cells in vitro.
Mortalin - a multipotent chaperone regulating cellular processes ranging from viral infection to neurodegeneration.
Multilevel regulation of RUVBL2 expression predicts poor prognosis in hepatocellular carcinoma.
Mutation of the co-chaperone Tsc1 in bladder cancer diminishes Hsp90 acetylation and reduces drug sensitivity and selectivity.
MZF1 and SCAND1 Reciprocally Regulate CDC37 Gene Expression in Prostate Cancer.
Neoisoliquiritigenin inhibits tumor progression by targeting GRP78-?-catenin signaling in breast cancer.
Nicotine increases oxidative stress, activates NF-kappaB and GRP78, induces apoptosis and sensitizes cells to genotoxic/xenobiotic stresses by a multiple stress inducer, deoxycholate: relevance to colon carcinogenesis.
Novobiocin decreases SMYD3 expression and inhibits the migration of MDA-MB-231 human breast cancer cells.
NVP-AUY922: a small molecule HSP90 inhibitor with potent antitumor activity in preclinical breast cancer models.
Oncogenic HSP60 regulates mitochondrial oxidative phosphorylation to support Erk1/2 activation during pancreatic cancer cell growth.
Oncogenic role of mortalin contributes to ovarian tumorigenesis by activating the MAPK-ERK pathway.
Overexpression and localization of heat shock proteins mRNA in pancreatic carcinoma.
Overexpression of 27-kDa heat shock protein relates to poor histological differentiation in human oesophageal squamous cell carcinoma.
Overexpression of GRP78 and GRP94 are markers for aggressive behavior and poor prognosis in gastric carcinomas.
Overexpression of GRP78 and GRP94 is involved in colorectal carcinogenesis.
Overexpression of PI3K-p110? in the progression of uterine cervical neoplasia and its correlation with pAkt and DJ-1.
P4HB promotes HCC tumorigenesis through downregulation of GRP78 and subsequent upregulation of epithelial-to-mesenchymal transition.
p53 modulates Hsp90 ATPase activity and regulates aryl hydrocarbon receptor signaling.
p53-HSP70 complexes in oral dysplasia and cancer: potential prognostic implications.
Pifithrin-? induces necroptosis through oxidative mitochondrial damage but accompanies epithelial-mesenchymal transition-like phenomenon in malignant mesothelioma cells under lactic acidosis.
Positive association of glucose-regulated protein 78 during oral cancer progression and the prognostic value in oral precancerous lesions.
Posttranslational modification and beyond: interplay between histone deacetylase 6 and heat-shock protein 90.
Potential Prognostic Value of Histone Deacetylase 6 and Acetylated Heat-Shock Protein 90 in Early-Stage Breast Cancer.
Preclinical antitumor activity of the orally available heat shock protein 90 inhibitor NVP-BEP800.
Prognostic significance of heat shock protein 70 expression in early gastric carcinoma.
Prospective identification of resistance mechanisms to HSP90 inhibition in KRAS mutant cancer cells.
Protective effect of Ocimum sanctum on 3-methylcholanthrene, 7,12-dimethylbenz(a)anthracene and aflatoxin B1 induced skin tumorigenesis in mice.
Protective role of genetic polymorphism of heat shock protein 70-2 for gastric cancer risk.
Proteomics-based identification of HSP60 as a tumor-associated antigen in early stage breast cancer and ductal carcinoma in situ.
Proteomics: a strategy to understand the novel targets in protein misfolding and cancer therapy.
Pten null prostate tumorigenesis and AKT activation are blocked by targeted knockout of ER chaperone GRP78/BiP in prostate epithelium.
Quantitative patterns of Hsps in tubular adenoma compared with normal and tumor tissues reveal the value of Hsp10 and Hsp60 in early diagnosis of large bowel cancer.
Quantum dot-based protein imaging and functional significance of two mitochondrial chaperones in cellular senescence and carcinogenesis.
Radiosensitization of human lung cancer cells by the novel purine-scaffold Hsp90 inhibitor, PU-H71.
Recent Understanding and Future Directions of Recurrent Corticotroph Tumors.
Reliability of HSP70 (HSPA) expression as a prognostic marker in glioma.
Repositioning of Verrucosidin, a purported inhibitor of chaperone protein GRP78, as an inhibitor of mitochondrial electron transport chain complex I.
Role of HSP60/HSP10 in Lung Cancer: Simple Biomarkers or Leading Actors?
Role of HSP90, CDC37, and CRM1 as modulators of P16(INK4A) activity in rat liver carcinogenesis and human liver cancer.
Role of Krüppel-like factor 4 and heat shock protein 27 in cancer of the larynx.
Roles of GRP78 in physiology and cancer.
Serum GRP78 as a Tumor Marker and Its Prognostic Significance in Non-Small Cell Lung Cancers: A Retrospective Study.
Silencing glucose-regulated protein 78 induced renal cell carcinoma cell line G1 cell-cycle arrest and resistance to conventional chemotherapy.
Steady-State Levels of Phosphorylated Mitogen-Activated Protein Kinase Kinase 1/2 Determined by Mortalin/HSPA9 and Protein Phosphatase 1 Alpha in KRAS and BRAF Tumor Cells.
Stress chaperone mortalin contributes to epithelial-mesenchymal transition and cancer metastasis.
Structural and functional differences between mouse mot-1 and mot-2 proteins that differ in two amino acids.
Structural and functional specificity of small heat shock protein HspB1 and HspB4, two cellular partners of HspB5: Role of the in vitro hetero-complex formation in chaperone activity.
Study of interactions energies between residues of the active site of Hsp90 and the geldanamycin analogues using Quantum Mechanics/Molecular Mechanics (QM/MM) methods.
Super-telomeres in transformed human fibroblasts.
Suppression of inflammatory cascade is implicated in methyl amooranin-mediated inhibition of experimental mammary carcinogenesis.
Synuclein ? protects Akt and mTOR and renders tumor resistance to Hsp90 disruption.
Synuclein gamma protects HER2 and renders resistance to Hsp90 disruption.
Targeting heat shock protein 90 for anti-cancer drug development.
Targeting heat shock protein 90 induces apoptosis and inhibits critical survival and proliferation pathways in multiple myeloma.
Targeting heat-shock-protein 90 (Hsp90) by natural products: geldanamycin, a show case in cancer therapy.
Targeting HSP90 for cancer therapy.
Targeting multiple signal transduction pathways through inhibition of Hsp90.
Targeting the hsp70 gene delays mammary tumor initiation and inhibits tumor cell metastasis.
Targeting the unfolded protein response in glioblastoma cells with the fusion protein EGF-SubA.
Ten kilodalton heat shock protein (HSP10) is overexpressed during carcinogenesis of large bowel and uterine exocervix.
The antitumor agent PBT-1 directly targets HSP90 and hnRNP A2/B1 and inhibits lung adenocarcinoma growth and metastasis.
The ATAD2/ANCCA homolog Yta7 cooperates with Scm3HJURP to deposit Cse4CENP-A at the centromere in yeast.
The clinicopathological significance of Mortalin overexpression in invasive ductal carcinoma of breast.
The co-chaperone UNC45A is essential for the expression of mitotic kinase NEK7 and tumorigenesis.
The critical role of GRP78 in physiologic and pathologic stress.
The deubiquitylase OTUD3 stabilizes GRP78 and promotes lung tumorigenesis.
The Interplay between Glucose-Regulated Protein 78 (GRP78) and Steroids in the Reproductive System.
The Molecular Chaperone Hsp90 Is Required for Cell Cycle Exit in Drosophila melanogaster.
The novel Hsp90 inhibitor NXD30001 induces tumor regression in a genetically engineered mouse model of glioblastoma multiforme.
The Role of Heat Shock Protein-90 in the Pathogenesis of Birt-Hogg-Dubé and Tuberous Sclerosis Complex Syndromes.
The role of the aryl hydrocarbon receptor-interacting protein gene in familial and sporadic pituitary adenomas.
The small heat shock protein ?A-crystallin negatively regulates pancreatic tumorigenesis.
TP53 status regulates ACSL5-induced expression of mitochondrial mortalin in enterocytes and colorectal adenocarcinomas.
trans, trans-2,4-Decadienal, a lipid peroxidation product, induces inflammatory responses via Hsp90- or 14-3-3?-dependent mechanisms.
Transcript response of soft coral (Scleronephthya gracillimum) on exposure to polycyclic aromatic hydrocarbons.
Transcriptional repression of the prosurvival endoplasmic reticulum chaperone GRP78/BIP by E2F1.
TRAP1 regulates stemness through Wnt/?-catenin pathway in human colorectal carcinoma.
Trianthema portulacastrum Linn. Displays Anti-Inflammatory Responses during Chemically Induced Rat Mammary Tumorigenesis through Simultaneous and Differential Regulation of NF-?B and Nrf2 Signaling Pathways.
TRIB1 Supports Prostate Tumorigenesis and Tumor-Propagating Cell Survival by Regulation of Endoplasmic Reticulum Chaperone Expression.
Tumor suppression by apoptotic and anti-angiogenic effects of mortalin-targeting adeno-oncolytic virus.
Tumor suppressor HLJ1 binds and functionally alters nucleophosmin via activating enhancer binding protein 2alpha complex formation.
Tumor-derived inducible heat-shock protein 70 (HSP70) is an essential component of anti-tumor immunity.
Ubiquitin ligase CHIP regulates OTUD3 stability and suppresses tumour metastasis in lung cancer.
Understanding the Hsp90 N-terminal Dynamics: Structural and Molecular Insights into the Therapeutic Activities of Anticancer Inhibitors Radicicol (RD) and Radicicol Derivative (NVP-YUA922).
Unleashing the full potential of Hsp90 inhibitors as cancer therapeutics through simultaneous inactivation of Hsp90, Grp94, and TRAP1.
Unusual Suspects in the Twilight Zone Between the Hsp90 Interactome and Carcinogenesis.
Up-Regulation of Cdc37 Contributes to Schwann Cell Proliferation and Migration After Sciatic Nerve Crush.
Upregulation of mortalin/mthsp70/Grp75 contributes to human carcinogenesis.
Viral insertion in Evi12 causes expression of aberrant Grp94 mRNAs containing the viral gag myristylation motif.
Yeast is selectively hypersensitised to heat shock protein 90 (Hsp90)-targetting drugs with heterologous expression of the human Hsp90beta, a property that can be exploited in screens for new Hsp90 chaperone inhibitors.
[Cloning and analysis of geldanamycin partial biosynthetic gene cluster of Streptomyces hygroscopicus 17997]
[Expressions of heat shock protein (HSP) family HSP 60, 70 and 90alpha in colorectal cancer tissues and their correlations to pathohistological characteristics.]
[Molecular chaperone HSP90 as a novel target for cancer chemotherapy]
[The correlation between the up-regulation of Hsp90 and drug resistance to cisplatin in lung cancer cell line].
[The effect of antisense hsp90 beta on the malignant phenotype and sensitivity of HeLa cells to chemotherapeutic drugs]
Carcinoid Tumor
Potent antitumor activity of the novel HSP90 inhibitors AUY922 and HSP990 in neuroendocrine carcinoid cells.
Carcinoma
(-)-Epigallocatechin-3-gallate is a novel Hsp90 inhibitor.
1,4-Naphthoquinone activates the HSP90/HSF1 pathway through the S-arylation of HSP90 in A431 cells: Negative regulation of the redox signal transduction pathway by persulfides/polysulfides.
17-Allylamino-17-Demethoxygeldanamycin and MEK1/2 Inhibitors Kill GI Tumor Cells via Ca2+-Dependent Suppression of GRP78/BiP and Induction of Ceramide and Reactive Oxygen Species.
18?-Glycyrrhetinic acid potentiates Hsp90 inhibition-induced apoptosis in human epithelial ovarian carcinoma cells via activation of death receptor and mitochondrial pathway.
2-phenylethynesulfonamide inhibits growth of oral squamous cell carcinoma cells by blocking the function of heat shock protein 70.
A high throughput substrate binding assay reveals hexachlorophene as an inhibitor of the ER-resident HSP70 chaperone GRP78.
A hsp70-2 mutation recognized by CTL on a human renal cell carcinoma.
A microRNA-27a mimic sensitizes human oral squamous cell carcinoma HSC-4 cells to hyperthermia through downregulation of Hsp110 and Hsp90.
A new tumor suppressor DnaJ-like heat shock protein, HLJ1, and survival of patients with non-small-cell lung carcinoma.
A novel intronic circular RNA, circGNG7, inhibits head and neck squamous cell carcinoma progression by blocking the phosphorylation of heat shock protein 27 at Ser78 and Ser82.
A novel mechanism for chaperone-mediated telomerase regulation during prostate cancer progression.
A novel, small molecule inhibitor of Hsc70/Hsp70 potentiates Hsp90 inhibitor induced apoptosis in HCT116 colon carcinoma cells.
A phase II trial of 17-(Allylamino)-17-demethoxygeldanamycin in patients with papillary and clear cell renal cell carcinoma.
A role for HMGB1, HSP60 and Myd88 in growth of murine mammary carcinoma in vitro.
A triazine compound S06 inhibits proinvasive crosstalk between carcinoma cells and stromal fibroblasts via binding to heat shock protein 90.
A unique role for heat shock protein 70 and its binding partner tissue transglutaminase in cancer cell migration.
Acquired resistance to HSP90 inhibitor 17-AAG and increased metastatic potential are associated with MUC1 expression in colon carcinoma cells.
Adaptation of Ehrlich ascites carcinoma cells to energy deprivation in vivo can be associated with heat shock protein accumulation.
Alpha B crystallin expression in response to hormone, oncogenes and stress.
Alteration in gene expression profile by full-length hepatitis B virus genome.
An immunohistochemical analysis of heat shock protein 70, p53, and estrogen receptor status in carcinoma of the uterine cervix.
Analysis of polypeptide expression in benign and malignant human breast lesions.
Analysis of polypeptide expression in benign and malignant human breast lesions: down-regulation of cytokeratins.
Antibodies to heat-shock protein 27 are associated with improved survival in patients with breast cancer.
Antitumor effect of novel HSP90 inhibitor NVP-AUY922 against oral squamous cell carcinoma.
Antitumorigenic Effect of Hsp90 Inhibitor SNX-2112 on Tongue Squamous Cell Carcinoma is Enhanced by Low-Intensity Ultrasound.
Association between hsp60 messenger-RNA levels and Cisplatin resistance in human head and neck-cancer cell-lines.
Association between HSP90 and Her2 in gastric and gastroesophageal carcinomas.
AuNPs modified, disposable, ITO based biosensor: Early diagnosis of heat shock protein 70.
Benzylidene lactam compound, KNK437, a novel inhibitor of acquisition of thermotolerance and heat shock protein induction in human colon carcinoma cells.
BIIB021, a novel Hsp90 inhibitor, sensitizes esophageal squamous cell carcinoma to radiation.
BIIB021, a novel HSP90 inhibitor, sensitizes head and neck squamous cell carcinoma to radiotherapy.
CD1A-positive cells and HSP60 (HSPD1) levels in keratoacanthoma and squamous cell carcinoma.
CD20+ Tumor Infiltrating B Lymphocyte in Oral Squamous Cell Carcinoma: Correlation with Clinicopathologic Characteristics and Heat Shock Protein 70 Expression.
Cell surface expression of 70 kDa heat shock protein in human oral dysplasia and squamous cell carcinoma: correlation with clinicopathological features.
Chaperone-Mediated Autophagy Markers LAMP2A and HSC70 Are Independent Adverse Prognostic Markers in Primary Resected Squamous Cell Carcinomas of the Lung.
Chaperonin (HSP60) and annexin-2 are candidate biomarkers for non-small cell lung carcinoma.
Characterization of Exosomes in Plasma of Patients with Breast, Ovarian, Prostate, Hepatic, Gastric, Colon, and Pancreatic Cancers.
Characterization of heat shock protein 27 phosphorylation sites in renal cell carcinoma.
Characterization of proteins associated with heat shock protein hsp27 in the squamous cell carcinoma cell line A431.
Clinical Implications of HSC70 Expression in Clear Cell Renal Cell Carcinoma.
Clinical Significance of Monitoring Circulating Free DNA and Plasma Heat Shock Protein 90alpha in Patients with Esophageal Squamous Cell Carcinoma.
Clinical significance of serum dynamics of HSP90a level in esophageal squamous cell carcinoma patients treated with definitive chemoradiotherapy.
Clinicopathological and genetic characteristics of mucinous carcinomas in the colorectum.
Co-expression of heat shock protein 70 and glucose-regulated protein 94 in human gastric carcinoma cell line BGC-823.
Co-overexpression of Bag-1 and heat shock protein 70 in human epidermal squamous cell carcinoma: Bag-1-mediated resistance to 5-fluorouracil-induced apoptosis.
Combination Treatment of Renal Cell Carcinoma with Belinostat and 5-Fluorouracil: A Role for Oxidative Stress Induced DNA Damage and HSP90 Regulated Thymidine Synthase.
Combined inhibition of extracellular signal-regulated kinases and HSP90 sensitizes human colon carcinoma cells to ionizing radiation.
Comparative analysis of novel and conventional Hsp90 inhibitors on HIF activity and angiogenic potential in clear cell renal cell carcinoma: implications for clinical evaluation.
Complex Formation between Heat Shock Protein 72 and Hepatitis B Virus X Protein in Hepatocellular Carcinoma Tissues.
Complex formation between heat shock protein 72 and hepatitis B virus X protein in hepatocellular carcinoma tissues.
Concentrations of antibodies against heat shock protein 27 in the sera of women with ovarian carcinoma.
Control of metastasized pancreatic carcinomas in SCID/beige mice with human IL-2/TKD-activated NK cells.
Correlation between clinicopathology and expression of heat shock protein 70 and glucose-regulated protein 94 in human colonic adenocarcinoma.
Correlation between clinicopathology and expression of heat shock protein 72 and glycoprotein 96 in human esophageal squamous cell carcinoma.
Correlation between crystal violet dissolution assay and manual colony counting on the in vitro effects of Hsp90-inhibitors.
Decreased GRP78 protein expression is a potential prognostic marker of oral squamous cell carcinoma in Taiwan.
Definition of extracellular localized epitopes of Hsp70 involved in an NK immune response.
Diagnostic value of heat shock protein 90? and squamous cell carcinoma antigen in detection of cervical cancer.
Diagnostic, clinicopathologic, therapeutic and prognostic value of Plasma Heat Shock Protein 90 levels in patients with advanced Gastrointestinal Carcinoma.
Different expression of CD44, ICAM-1, and HSP60 on primary tumor and metastases of a human pancreatic carcinoma growing in scid mice.
Differential expression of heat shock protein 27 in normal oral mucosa, oral epithelial dysplasia and squamous cell carcinoma.
Differential Expression of Heat Shock Protein 27 in Oral Epithelial Dysplasias and Squamous Cell Carcinoma.
Differential expression of hsp90, gelsolin and gst-pi in human gastric-carcinoma cell-lines.
Differential expression of Mr 70,000 heat shock protein in normal, premalignant, and malignant human uterine cervix.
Differentiation of normal and cancer cells induced by sulfhydryl reduction: biochemical and molecular mechanisms.
Discovering High Potent Hsp90 Inhibitors as Antinasopharyngeal Carcinoma Agents through Fragment Assembling Approach.
Disseminated Tumor Cells Persist in the Bone Marrow of Breast Cancer Patients through Sustained Activation of the Unfolded Protein Response.
Double immunostaining for p53 and molecular chaperone hsp72/73 in gastric carcinoma.
Downregulation of HSP60 disrupts mitochondrial proteostasis to promote tumorigenesis and progression in clear cell renal cell carcinoma.
Downregulation of the tumor suppressor HSPB7, involved in the p53 pathway, in renal cell carcinoma by hypermethylation.
Dual function of membrane-bound heat shock protein 70 (Hsp70), Bag-4, and Hsp40: protection against radiation-induced effects and target structure for natural killer cells.
Dual PI3K- and mTOR-inhibitor PI-103 can either enhance or reduce the radiosensitizing effect of the Hsp90 inhibitor NVP-AUY922 in tumor cells: The role of drug-irradiation schedule.
Dysregulation of heat shock protein 27 expression in oral tongue squamous cell carcinoma.
Effect of 17-allylamino-17-demethoxygeldanamycin (17-AAG) on Akt protein expression is more effective in head and neck cancer cell lineages that retain PTEN protein expression.
Effect of hypoxia on the expression of alphaB-crystallin in head and neck squamous cell carcinoma.
Effect of social housing condition on heat shock protein (HSP) expression in the Shionogi mouse mammary carcinoma (SC115).
Effects of 17-allylamino-17-demethoxygeldanamycin on the induction of apoptosis and cell cycle arrest in HCT-116 cells.
Effects of a heat shock protein inhibitor KNK437 on heat sensitivity and heat tolerance in human squamous cell carcinoma cell lines differing in p53 status.
Effects of a Unique Combination of the Whole-Body Low Dose Radiotherapy with Inactivation of Two Immune Checkpoints and/or a Heat Shock Protein on the Transplantable Lung Cancer in Mice.
Effects of far infrared radiation by isotropic high-density carbon on the human oral mucosa.
Effects of the novel heat shock protein 90 inhibitor AUY922 in renal cell carcinoma ACHN and 786-O cells.
Efficacy of Hsp90 inhibition for induction of apoptosis and inhibition of growth in cervical carcinoma cells in vitro and in vivo.
EIF3D promotes sunitinib resistance of renal cell carcinoma by interacting with GRP78 and inhibiting its degradation.
Emphasizing on heat shock protein 90's utility in head and neck squamous cell carcinoma treatment.
Enhancing HSP70-ShRNA transfection in 22RV1 prostate cancer cells by combination of sonoporation, liposomes and HTERT/CMV chimeric promoter.
Epstein-Barr virus upregulates phosphorylated heat shock protein 27 kDa in carcinoma cells using the phosphoinositide 3-kinase/Akt pathway.
Estramustine phosphate enhances the effects of hyperthermia and induces the small heat shock protein HSP27 in the human prostate carcinoma cell line PC-3.
Estrogen receptor-?36-mediated rapid estrogen signaling regulates 78 kDa glucose-regulated protein expression in gastric carcinoma cells.
Etoposide-resistant HT-29 human colon carcinoma cells during glucose deprivation are sensitive to piericidin A, a GRP78 down-regulator.
Evaluation of renal cell carcinoma vaccines targeting carbonic anhydrase IX using heat shock protein 110.
Ex vivo Hsp70-Activated NK Cells in Combination With PD-1 Inhibition Significantly Increase Overall Survival in Preclinical Models of Glioblastoma and Lung Cancer.
Expression analysis of heat shock protein 90 (HSP90) and Her2 in colon carcinoma.
Expression and localization of GRP75 in human epithelial tumors and normal tissues.
Expression and significance of heat shock protein 70 and glucose-regulated protein 94 in human esophageal carcinoma.
Expression of 60-kD heat shock protein increases during carcinogenesis in the uterine exocervix.
Expression of autophagy and ER stress-related proteins in primary salivary adenoid cystic carcinoma.
Expression of ER stress and autophagy-related molecules in human non-small cell lung cancer and premalignant lesions.
Expression of ER stress markers (GRP78/BiP and PERK) in adenoid cystic carcinoma.
Expression of Heat Shock Protein 105 in Cutaneous Squamous Cell Carcinoma: Correlation with Clinicopathological Characteristics.
Expression of heat shock protein 27 in human renal cell carcinoma.
Expression of heat shock protein 70 and c-myc in cervical carcinoma.
Expression of heat shock protein 70 in grossly resected esophageal squamous cell carcinoma.
Expression of Heat Shock Protein 70 in Oral Epithelial Dysplasia and Oral Squamous Cell Carcinoma: An Immunohistochemical Study.
Expression of heat shock protein 70 in renal cell carcinoma and its relation to tumor progression and prognosis.
Expression of heat shock protein 72 in renal cell carcinoma: possible role and prognostic implications in cancer patients.
Expression of heat shock protein70 in oral submucous fibrosis and oral squamous cell carcinoma: an immunohistochemical study.
Expression of heat shock proteins and heat shock protein messenger ribonucleic acid in human prostate carcinoma in vitro and in tumors in vivo.
Expression of heat shock proteins HSP70 and HSP90 in endometrial carcinomas. Correlation with clinicopathology, sex steroid receptor status, and p53 protein expression.
Expression of heat shock proteins in premalignant and malignant urothelial lesions of bovine urinary bladder.
Expression of heat shock proteins in squamous cell carcinoma of the tongue: an immunohistochemical study.
Expression of heat-shock protein Hsp60 correlated with the apoptotic index and patient prognosis in human oesophageal squamous cell carcinoma.
Expression of heat-shock proteins hsp27, hsp70 and hsp90 in malignant epithelial tumour of the ovaries.
Expression of HSP27, HSP72 and MRP proteins in in vitro co-culture of colon tumour cell spheroids with normal cells after incubation with rhTGF- beta1 and/or CPT-11.
Expression of interleukin-6 is downregulated by 17-(allylamino)-17-demethoxygeldanamycin in human prostatic carcinoma cells.
Expression of the 27-kDa heat shock protein (HSP27) in gastric carcinomas and adjacent normal, metaplastic, and dysplastic gastric mucosa, and its prognostic significance.
Expression pattern of heat shock protein 90 in patients with oral squamous cell carcinoma in northern Taiwan.
Expression patterns of aurora kinase B, heat shock protein 47, and periostin in esophageal squamous cell carcinoma.
Extracellular heat shock protein 70 mediates heat stress-induced epidermal growth factor receptor transactivation in A431 carcinoma cells.
Extracellular heat shock protein A9 is a novel interaction partner of podoplanin in oral squamous cell carcinoma cells.
Flow cytometric analysis of the heat shock protein 60 expressed on the cell surface of Helicobacter pylori.
Fluoxetine-induced regulation of heat shock protein 90 and 14-3-3? in human embryonic carcinoma cells.
Geldanamycin mediates the apoptosis of gastric carcinoma cells through inhibition of EphA2 protein expression.
Geldanamycin, an inhibitor of Hsp90, sensitizes human tumour cells to radiation.
Germ cell-specific heat shock protein 70-2 is expressed in cervical carcinoma and is involved in the growth, migration, and invasion of cervical cells.
Glucose-deprived HT-29 human colon carcinoma cells are sensitive to verrucosidin as a GRP78 down-regulator.
Glucose-regulated protein 78 expression in urothelial carcinoma of the upper urinary tract.
Glucose-related protein (GRP78) and its relationship to the drug-resistance proteins P170, GST-pi, LRP56 and angiogenesis in non-small cell lung carcinomas.
GRP78 expression in tumor and perinephric adipose tissue is not an optimal risk stratification marker for clear cell renal cell carcinoma.
Heat shock protein (HSP72) surface expression enhances the lysis of a human renal cell carcinoma by IL-2 stimulated NK cells.
Heat shock protein 105 is overexpressed in squamous cell carcinoma and extramammary Paget disease but not in basal cell carcinoma.
Heat shock protein 27 and p16 immunohistochemistry in cervical intraepithelial neoplasia and squamous cell carcinoma.
Heat Shock Protein 27 as a New Therapeutic Target for Radiation Sensitization of Head and Neck Squamous Cell Carcinoma.
Heat shock protein 27 enhances the tumorigenicity of immunogenic rat colon carcinoma cell clones.
Heat shock protein 27 expression in areca quid chewing-associated oral squamous cell carcinomas.
Heat shock protein 27: an independent prognostic indicator of survival in patients with epithelial ovarian carcinoma.
Heat shock protein 47 expression in oral squamous cell carcinomas and upregulated by arecoline in human oral epithelial cells.
Heat shock protein 60 levels in tissue and circulating exosomes in human large bowel cancer before and after ablative surgery.
Heat shock protein 60 overexpression is associated with the progression and prognosis in gastric cancer.
Heat shock protein 70 and tumor-infiltrating NK cells as prognostic indicators for patients with squamous cell carcinoma of the head and neck after radiochemotherapy: A multicentre retrospective study of the German Cancer Consortium Radiation Oncology Group (DKTK-ROG).
Heat shock protein 70 expression in relation to apoptosis in primary bladder transitional cell carcinoma.
Heat shock protein 70 is acute phase reactant: response elicited by tumor treatment with photodynamic therapy.
Heat shock protein 70 is involved in malignant behaviors and chemosensitivities to cisplatin in cervical squamous cell carcinoma cells.
Heat shock protein 70 surface-positive tumor exosomes stimulate migratory and cytolytic activity of natural killer cells.
Heat shock protein 70-2 (HSP70-2) is a novel therapeutic target for colorectal cancer and is associated with tumor growth.
Heat shock protein 72 associated with CD44v6 in human colonic adenocarcinoma.
Heat shock protein 72 does not modulate ionizing radiation-induced apoptosis in U1810 non-small cell lung carcinoma cells.
Heat shock protein 90 (HSP90) is overexpressed in p16-negative oropharyngeal squamous cell carcinoma, and its inhibition in vitro potentiates the effects of chemoradiation.
Heat shock protein 90 inhibitor 17-allylamino-17-demethoxygeldanamycin potentiates the radiation response of tumor cells grown as monolayer cultures and spheroids by inducing apoptosis.
Heat shock protein 90 is a putative therapeutic target in patients with recurrent advanced-stage ovarian carcinoma with serous effusions.
Heat Shock Protein 90 is Associated with Hyperplasia and Neoplastic Transformation of Canine Prostatic Epithelial Cells.
Heat shock protein and p53 expression in head and neck squamous cell carcinoma.
Heat shock protein expression and anti-heat shock protein reactivity in renal cell carcinoma.
Heat shock protein expression in canine malignant mammary tumours.
Heat shock protein expression in oral epithelial dysplasia and squamous cell carcinoma.
Heat shock protein family B member 1 facilitates ezrin activation to control cell migration in esophageal squamous cell carcinoma.
Heat shock protein HSP 27 is expressed in all types of basal cell carcinoma in low and high risk UV exposure groups.
Heat shock proteins HSP27, HSP60, HSP70, and HSP90: expression in bladder carcinoma.
Heat Shock Proteins: A Potential Anticancer Target.
Heat-shock protein 70 as a tumor antigen for in vitro dendritic cell pulsing in renal cell carcinoma cases.
Heat-shock protein 70-2 (HSP70-2) expression in bladder urothelial carcinoma is associated with tumour progression and promotes migration and invasion.
Heat-shock protein 90 (Hsp90) as a molecular target for therapy of gastrointestinal cancer.
Heat-shock protein 90 inhibitors synergistically enhance melanoma differentiation-associated gene-7-mediated cell killing of human pancreatic carcinoma.
High Expression of GRP78 Promotes Invasion and Metastases in Patients with Esophageal Squamous Cell Carcinoma.
High expression of heat shock protein 90 is associated with tumor aggressiveness and poor prognosis in patients with advanced gastric cancer.
High glucose uptake unexpectedly is accompanied by high levels of the mitochondrial ß-F1-ATPase subunit in head and neck squamous cell carcinoma.
High-throughput screening fluorescence polarization assay for tumor-specific hsp90.
HSP DNAJB8 controls tumor-initiating ability in renal cancer stem-like cells.
Hsp-27 has no diagnostic or prognostic significance in prostate or bladder cancers.
HSP105 expression in oral squamous cell carcinoma: Correlation with clinicopathological features and outcomes.
Hsp27 modulates p53 signaling and suppresses cellular senescence.
HSP60 and HSP10 as diagnostic and prognostic tools in the management of exocervical carcinoma.
HSP60 silencing promotes Warburg-like phenotypes and switches the mitochondrial function from ATP production to biosynthesis in ccRCC cells.
HSP70: a promising target for laryngeal carcinoma radiaotherapy by inhibiting cleavage and degradation of nucleolin.
Hsp90 as a therapeutic target in patients with oesophageal carcinoma.
Hsp90 inhibition by NVP-AUY922 and NVP-BEP800 decreases migration and invasion of irradiated normoxic and hypoxic tumor cell lines.
Hsp90 inhibitor can inhibit UV carcinogenesis.
HSP90 Inhibitor Ganetespib (STA-9090) Inhibits Tumor Growth in c-Myc-Dependent Esophageal Squamous Cell Carcinoma.
HSP90 Inhibitor SNX5422/2112 Targets the Dysregulated Signal and Transcription Factor Network and Malignant Phenotype of Head and Neck Squamous Cell Carcinoma.
Hsp90 inhibitors cause G2/M arrest associated with the reduction of Cdc25C and Cdc2 in lung cancer cell lines.
Hsp90 is expressed and represents a therapeutic target in human oesophageal cancer using the inhibitor 17-allylamino-17-demethoxygeldanamycin.
Hsp90 stabilizes Cdc25A and counteracts heat shock-mediated Cdc25A degradation and cell-cycle attenuation in pancreatic carcinoma cells.
Identification of candidate antigens for serologic detection of Helicobacter pylori-infected patients with gastric carcinoma.
Identification of heat shock protein 90 and other proteins as tumour antigens by serological screening of an ovarian carcinoma expression library.
Identification of tumor-associated proteins in oral tongue squamous cell carcinoma by proteomics.
IKK{gamma} protein is a target of BAG3 regulatory activity in human tumor growth.
Immunohistochemical analysis of p53 protein and 72 kDa heat shock protein (HSP72) expression in ovarian carcinomas. Correlation with clinicopathology and sex steroid receptor status.
Immunohistochemical detection of HSP60-expression in human ovarian cancer. Correlation with survival in a series of 247 patients.
Immunohistochemical expression of heat shock proteins, p63 and androgen receptor in benign prostatic hyperplasia and prostatic carcinoma in the dog.
Immunohistochemical expression of interlukin10 (IL10) and heat shock protein-90 (HSP-90) in prostatic carcinoma.
Immunotherapy of a human papillomavirus (HPV) type 16 E7-expressing tumour by administration of fusion protein comprising Mycobacterium bovis bacille Calmette-Guérin (BCG) hsp65 and HPV16 E7.
Increase of P-glycoprotein-mediated drug resistance by hsp 90 beta.
Increased expression of co-chaperone HOP with HSP90 and HSC70 and complex formation in human colonic carcinoma.
Increased expression of HSP70 by colon cancer cells is not always associated with access to the dendritic cell cross-presentation pathway.
Increased expression of the major heat shock protein Hsp72 in human prostate carcinoma cells is dispensable for their viability but confers resistance to a variety of anticancer agents.
Induction and epitope analysis of Helicobacter pylori heat shock protein.
Induction and membrane expression of heat shock proteins in heat-treated HPC-4 cells is correlated with increased resistance to LAK-mediated lysis.
Induction of heat shock protein 70 inhibits NF-kappa-B in squamous cell carcinoma.
Induction of the 72-kD heat shock protein in human skin melanoma and squamous cell carcinoma cell lines.
Inhibition of endoplasmic reticulum chaperone protein glucose-regulated protein 78 potentiates anti-angiogenic therapy in renal cell carcinoma through inactivation of the PERK/eIF2? pathway.
Inhibition of GRP78 abrogates radioresistance in oropharyngeal carcinoma cells after EGFR inhibition by cetuximab.
Inhibition of heat shock protein expression by Helicobacter pylori.
Inhibition of Hsp90 activates osteoclast c-Src signaling and promotes growth of prostate carcinoma cells in bone.
Interaction between heat shock protein 72 and alpha-fetoprotein in human hepatocellular carcinomas.
Intronic polymorphism (1541-1542delGT) of the constitutive heat shock protein 70 gene has functional significance and shows evidence of association with lung cancer risk.
Involvement of GRP78 in the Resistance of Ovarian Carcinoma Cells to Paclitaxel.
Is p53 and heat shock protein 70 expression a useful parameter for preoperative hyperthermoradiation therapy in advanced rectal carcinoma.
Isoxazolo(aza)naphthoquinones: a new class of cytotoxic Hsp90 inhibitors.
Knockdown of glucose-regulated protein 78 abrogates chemoresistance of hypopharyngeal carcinoma cells to cisplatin induced by unfolded protein in response to severe hypoxia.
Kynuramines induce overexpression of heat shock proteins in pancreatic cancer cells via 5-hydroxytryptamine and MT1/MT2 receptors.
Lens epithelium-derived growth factor is an Hsp70-2 regulated guardian of lysosomal stability in human cancer.
Low dose geldanamycin inhibits hepatocyte growth factor and hypoxia-stimulated invasion of cancer cells.
Luteolin induces carcinoma cell apoptosis through binding Hsp90 to suppress constitutive activation of STAT3.
MEK-inhibitor PD184352 enhances the radiosensitizing effect of the Hsp90 inhibitor NVP-AUY922: the role of cell type and drug-irradiation schedule.
Membrane Hsp70-supported cell-to-cell connections via tunneling nanotubes revealed by live-cell STED nanoscopy.
Metastasis and the Tumor Microenvironment: A Joint Metastasis Research Society-AACR Conference - Research on Metastasis: Part 2.
MicroRNA-27a downregulates the expression of Hsp90 and enhances the radiosensitivity in esophageal squamous cell carcinoma.
MicroRNA-30a-5p Inhibits the Growth of Renal Cell Carcinoma by Modulating GRP78 Expression.
Mode of cell death induced by the HSP90 inhibitor 17-AAG (tanespimycin) is dependent on the expression of pro-apoptotic BAX.
Molecular imaging of EGFR and CD44v6 for prediction and response monitoring of HSP90 inhibition in an in vivo squamous cell carcinoma model.
Mortalin is a distinct bio-marker and prognostic factor in serous ovarian carcinoma.
Mps1 Mediated Phosphorylation of Hsp90 Confers Renal Cell Carcinoma Sensitivity and Selectivity to Hsp90 Inhibitors.
mRNA levels of molecular chaperones hsp27, hsp60 and hsp70 in cisplatin resistant squamous cell carcinomas.
Natural and semisynthetic azaphilones as a new scaffold for Hsp90 inhibitors.
Novel C-Terminal Heat Shock Protein 90 Inhibitors (KU711 and Ku757) Are Effective in Targeting Head and Neck Squamous Cell Carcinoma Cancer Stem cells.
Novel Heat Shock Protein 90 Inhibitors Suppress P-Glycoprotein Activity and Overcome Multidrug Resistance in Cancer Cells.
Novel HSP90 Inhibitor NVP-AUY922 enhances the anti-tumor effect of temsirolimus against oral squamous cell carcinoma.
Novel ovarian cancer maintenance therapy targeted at mortalin and mutant p53.
Nucleofection of non-B cells with mini-Epstein-Barr virus DNA.
Overexpression and localization of heat shock proteins mRNA in pancreatic carcinoma.
Overexpression of 27-kDa heat shock protein relates to poor histological differentiation in human oesophageal squamous cell carcinoma.
Overexpression of endoplasmic reticulum stress-related proteins, XBP1s and GRP78, predicts poor prognosis in pulmonary adenocarcinoma.
Overexpression of glucose-regulated protein 78 in colon cancer.
Overexpression of GRP78 and GRP94 are markers for aggressive behavior and poor prognosis in gastric carcinomas.
Overexpression of GRP78 and GRP94 is involved in colorectal carcinogenesis.
Overexpression of GRP78 is associated with malignant transformation in epithelial ovarian tumors.
Overexpression of heat shock protein 27 (HSP-27) is associated with bad prognosis in oral squamous cell carcinoma.
Overexpression of heat shock protein 27 in squamous cell carcinoma of the uterine cervix.
Overexpression of heat shock protein 27 in squamous cell carcinoma of the uterine cervix: a proteomic analysis using archival formalin-fixed, paraffin-embedded tissues.
Overexpression of heat shock protein 27 is associated with good prognosis in the patient with oral squamous cell carcinoma.
Overexpression of the small heat shock protein, hsp27, confers resistance to hyperthermia, but not to oxidative stress and UV-induced cell death, in a stably transfected squamous cell carcinoma cell line.
p53 mutations, ras mutations, and p53-heat shock 70 protein complexes in human lung carcinoma cell lines.
P53-dependent radiosensitizing effects of Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin on human oral squamous cell carcinoma cell lines.
Papers to Appear in Forthcoming Issues
Peripheral blood mononuclear cell proliferation to heat shock protein-70 derived from autologous lung carcinoma.
Pharmacological Inhibition of HSP90 Radiosensitizes Head and Neck Squamous Cell Carcinoma Xenograft by Inhibition of DNA Damage Repair, Nucleotide Metabolism, and Radiation-Induced Tumor Vasculogenesis.
Polymorphic analysis of MHClinked Heat Shock Protein 70 genes: Their susceptibility and prognostic implication in Kangri cancer cases of Kashmiri population.
Potent activity of a novel dimeric heat shock protein 90 inhibitor against head and neck squamous cell carcinoma in vitro and in vivo.
Potentiation of paclitaxel activity by the HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin in human ovarian carcinoma cell lines with high levels of activated AKT.
Preventive and therapeutic effect of tumor derived heat shock protein, gp96, in an experimental prostate cancer model.
Pro-apoptotic effect of haem oxygenase-1 in human colorectal carcinoma cells via endoplasmic reticular stress.
Prognostic significance of heat shock protein 27 (HSP27) in patients with oral squamous cell carcinoma.
Prognostic significance of heat shock protein 70 expression in early gastric carcinoma.
Prognostic significance of heat shock proteins HSP70 and HSP90 in endometrial carcinomas.
Proliferating cell nuclear antigen and heat shock protein 70 immunolocalization in invasive ductal breast cancer not otherwise specified.
Promoter methylation of heat shock protein B2 in human esophageal squamous cell carcinoma.
Protein Expression Profile using Two-Dimensional Gel Analysis in Squamous Cervical Cancer Patients.
Protein expression profiling of normal and neoplastic canine prostate and bladder tissue.
Proteomic analysis of proteome and histone post-translational modifications in heat shock protein 90 inhibition-mediated bladder cancer therapeutics.
Proteomic approaches to study epigallocatechin gallate-provoked apoptosis of TSGH-8301 human urinary bladder carcinoma cells: Roles of AKT and heat shock protein 27-modulated intrinsic apoptotic pathways.
Proteomics-based identification of autoantibody against heat shock protein 70 as a diagnostic marker in esophageal squamous cell carcinoma.
Quality of life in patients with metastatic renal cell carcinoma participating in a phase I trial of an autologous tumor-derived vaccine.
Quantitative score modulation of HSP90 and HSP27 in clear cell renal cell carcinoma.
Quercetin, an inhibitor of heat shock protein synthesis, inhibits the acquisition of thermotolerance in a human colon carcinoma cell line.
Quinazoline Based HSP90 Inhibitors: Synthesis, Modeling Study and ADME Calculations Towards Breast Cancer Targeting.
Radicicol, an inhibitor of Hsp90, enhances TRAIL-induced apoptosis in human epithelial ovarian carcinoma cells by promoting activation of apoptosis-related proteins.
Radiosensitization of human lung cancer cells by the novel purine-scaffold Hsp90 inhibitor, PU-H71.
Regulation of HSP60 mRNA expression in a human ovarian carcinoma cell line.
Relationship between expression of HSP60, urease activity, production of vacuolating toxin, and adherence activity of Helicobacter pylori.
Relationship between heat shock protein 60 (HSP60) mRNA expression and resistance to platinum analogues in human ovarian and bladder carcinoma cell lines.
Relationship between toxicity of selected insecticides and expression of stress proteins (HSP, GRP) in cultured human cells: Effects of commercial formulations versus pure active molecules.
Retraction: Potentiation of Paclitaxel Activity by the HSP90 Inhibitor 17-allylamino-17-demethoxygeldanamycin in Human Ovarian Carcinoma Cell Lines with High Levels of Activated AKT.
RT-PCR Quantitation of HSP60 mRNA Expression.
Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer.
Selective cytotoxic activity of valinomycin against HT-29 Human colon carcinoma cells via down-regulation of GRP78.
Serum antibody response to the heat shock protein 60 of Chlamydia trachomatis in women with developing cervical cancer.
Serum heat shock protein 27 is increased in chronic pancreatitis and pancreatic carcinoma.
Significance of expression of heat shock protein90alpha in human gastric cancer.
Significance of heat shock protein-27 expression in patients with renal cell carcinoma.
Silence of HDAC6 suppressed esophageal squamous cell carcinoma proliferation and migration by disrupting chaperone function of HSP90.
Silencing of heat shock protein 27 increases the radiosensitivity of non?small cell lung carcinoma cells.
Single-Cell RNA Sequencing Identifies Yes-Associated Protein 1-Dependent Hepatic Mesothelial Progenitors in Fibrolamellar Carcinoma.
Single-Cell Sequencing to Identify Six Heat Shock Protein (HSP) Genes-Mediated Progression Subtypes of Clear Cell Renal Cell Carcinoma.
Small heat shock protein hsp27 as a possible mediator of intercellular adhesion-induced drug resistance in human larynx carcinoma HEp-2 cells.
Sulfoxythiocarbamate S-4 inhibits HSP90 in human cutaneous squamous cell carcinoma cells.
SUMOylation of HSP27 regulates PKM2 to promote esophageal squamous cell carcinoma progression.
Suppression of the transformed phenotype and induction of differentiation-like characteristics in cultured ovarian tumor cells by chronic treatment with progesterone.
Suppression of tumor necrosis factor receptor-associated protein 1 expression induces inhibition of cell proliferation and tumor growth in human esophageal cancer cells.
Suppressive subtractive hybridisation reveals differential expression of serglycin, sorcin, bone marrow proteoglycan and prostate-tumour-inducing gene I (PTI-1) in drug-resistant and sensitive tumour cell lines of haematopoetic origin.
Surface expression of a C-terminal alpha-helix region in heat shock protein 72 on murine LL/2 lung carcinoma can be recognized by innate immune sentinels.
Synergistic effect of heat shock protein 90 inhibitor, 17-allylamino-17-demethoxygeldanamycin and X-rays, but not carbon-ion beams, on lethality in human oral squamous cell carcinoma cells.
Targeted blockade of HSP90 impairs DNA-damage response proteins and increases the sensitivity of ovarian carcinoma cells to PARP inhibition.
Targeting heat shock response to sensitize cancer cells to proteasome and Hsp90 inhibitors.
Targeting Hsp90 in urothelial carcinoma.
The 650-kDa 12(S)-hydroxyeicosatetraenoic acid binding complex: occurrence in human platelets, identification of hsp90 as a constituent, and binding properties of its 50-kDa subunit.
The effects of irradiation on the expression of a tumour rejection antigen (heat shock protein gp96) in human cervical cancer.
The expression of HSP60 and HSP10 in large bowel carcinomas with lymph node metastase.
The GroEL protein of Porphyromonas gingivalis accelerates tumor growth by enhancing endothelial progenitor cell function and neovascularization.
The histone deacetylase inhibitor SAHA induces HSP60 nitration and its extracellular release by exosomal vesicles in human lung-derived carcinoma cells.
The HSP90 inhibitor 17-N-allylamino-17-demethoxy geldanamycin (17-AAG) synergizes with cisplatin and induces apoptosis in cisplatin-resistant esophageal squamous cell carcinoma cell lines via the Akt/XIAP pathway.
The novel HSP90 inhibitor AT13387 potentiates radiation effects in squamous cell carcinoma and adenocarcinoma cells.
The role of checkpoint kinase 1 in sensitivity to topoisomerase I poisons.
The upregulation of heat shock protein 70 expression in areca quid chewing-associated oral squamous cell carcinomas.
Therapeutic effects of radiolabeled 17-allylamino-17-demethoxygeldanamycin on human H460 nonsmall-cell lung carcinoma xenografts in mice.
Therapeutic uses of HSP90 inhibitors in Non-Small Cell Lung Carcinoma (NSCLC).
Topically Applied Hsp90 Inhibitor 17AAG Inhibits UVR-Induced Cutaneous Squamous Cell Carcinomas.
TRAP1 controls cell cycle G2-M transition through the regulation of CDK1 and MAD2 expression/ubiquitination.
Tricyclic series of heat shock protein 90 (Hsp90) inhibitors part I: discovery of tricyclic imidazo[4,5-c]pyridines as potent inhibitors of the Hsp90 molecular chaperone.
Triple knockdown of CDC37, HSP90-alpha and HSP90-beta diminishes extracellular vesicles-driven malignancy events and macrophage M2 polarization in oral cancer.
Tumor Suppression Efficacy of Heat Shock Protein 90 Inhibitor 17AAG in a Liposarcoma Mouse Model.
Two-dimensional gel analysis of protein expression profile in squamous cervical cancer patients.
Upregulation of GRP78 in Renal Cell Carcinoma and Its Significance.
Use of protein-based biomarkers of exfoliated cervical cells for primary screening of cervical cancer.
[Adenovirus-mediated antisense HSP70 cDNA transfection inhibits the growth of laryngeal carcinoma Hep-2 cells]
[Anticancer therapeutic effect of SEA-linked and membrane-bound HSP70-expressed intestine-carcinoma vaccine]
[Antitumor therapeutic effect induced by intestine- carcinoma cells vaccine expressing membrane-bound heat shock protein 70]
[Biology behavior of head and neck squamous cell cancer cells changes after knocking down heat shock protein 27].
[Comparative study of expression levels of the major human heat shock proteins in cancer and normal tissues]
[Diagnosis value of combined detection of serum golgi protein 73, desgamma carboxy prothrombin and ?-fetoprotein in primary hepatic carcinoma].
[Effect of glucose regulated protein 78 on autophagy and apoptosis in ovarian epithelial carcinoma].
[Expression and significance of heat shock proteins in esophageal squamous cell carcinoma]
[Expression and significance of Hsp70 and PCNA during the development of forestomach carcinoma in NIH mice]
[Expression of heat shock protein-70, estrogen receptor and progesterone receptor in ovarian carcinomas and the correlation between HSP70 and sex steroid receptor]
[Expression of heat shock proteins in laryngeal carcinoma]
[Expression of Hsp70 Grp94 and IgG in human lung carcinoma.]
[Hypoxia induces heat shock protein HSP70-2 expression in a HIF-1 dependent manner.]
[Influence of the expression of heat shock protein 70 in maxillofacial squamous cell carcinoma by thermochemotherapy]
[Isolation, identification and clinical significance of ascites-derived exosomes from patients with ovarian epithelial cancer]
[Pancreatic acinar neoplasms : Comparative molecular characterization].
[Preliminary study on glucose regulated protein 78 kD and heat shock protein 20 differential expression between left-sided colon carcinoma and right-sided colon carcinoma].
[Screening of differentially expressed proteins from human esophageal cancer and esophageal tissues by two-dimensional difference gel electrophoresis and mass spectrometry]
[Study on expression of cell cycle-related genes in subclonal cell lines of human cervical carcinoma]
[The role of the heat shock protein in human breast cancer]
Carcinoma in Situ
Heat shock proteins HSP27, HSP60, HSP70, and HSP90: expression in bladder carcinoma.
Overexpression of heat shock protein 27 in squamous cell carcinoma of the uterine cervix: a proteomic analysis using archival formalin-fixed, paraffin-embedded tissues.
Carcinoma, Acinar Cell
[Pancreatic acinar neoplasms : Comparative molecular characterization].
Carcinoma, Adenoid Cystic
Expression of autophagy and ER stress-related proteins in primary salivary adenoid cystic carcinoma.
Expression of ER stress markers (GRP78/BiP and PERK) in adenoid cystic carcinoma.
Carcinoma, Adenosquamous
Hsp60 and Hsp10 down-regulation predicts bronchial epithelial carcinogenesis in smokers with chronic obstructive pulmonary disease.
Carcinoma, Basal Cell
Heat shock protein 105 is overexpressed in squamous cell carcinoma and extramammary Paget disease but not in basal cell carcinoma.
Heat shock protein HSP 27 is expressed in all types of basal cell carcinoma in low and high risk UV exposure groups.
Carcinoma, Ductal
Comparison of the desmoplastic reaction and invading ability in invasive ductal carcinoma of the breast and prostatic adenocarcinoma based on the expression of heat shock protein 47 and fascin.
Decreased Hsp90 expression in infiltrative lobular carcinoma: an immunohistochemical study.
Elevated expression of nuclear Hsp90 in invasive breast tumors.
Heat shock protein 27 overexpression in breast cancer lymph node metastasis.
Heat shock protein 90 (hsp90) expression and breast cancer.
Hsp-27 has no diagnostic or prognostic significance in prostate or bladder cancers.
Hsp90 in the continuum of breast ductal carcinogenesis: Evaluation in precursors, preinvasive and ductal carcinoma lesions.
Metastasis and the Tumor Microenvironment: A Joint Metastasis Research Society-AACR Conference - Research on Metastasis: Part 2.
Proteomics-based identification of HSP60 as a tumor-associated antigen in early stage breast cancer and ductal carcinoma in situ.
Serum levels of HSP90 in the continuum of breast ductal and lobular lesions.
The clinicopathological significance of Mortalin overexpression in invasive ductal carcinoma of breast.
Carcinoma, Ehrlich Tumor
Cisplatin induces the small heat shock protein hsp25 and thermotolerance in Ehrlich ascites tumor cells.
Dephosphorylation of the small heat shock protein hsp25 by calcium/calmodulin-dependent (type 2B) protein phosphatase.
Identification of the phosphorylation sites of the murine small heat shock protein hsp25.
The anti-cancer drug cisplatin induces H25 in Ehrlich ascites tumor cells by a mechanism different from transcriptional stimulation influencing predominantly H25 translation.
Carcinoma, Embryonal
A Chemical Biology Study of Human Pluripotent Stem Cells Unveils HSPA8 as a Key Regulator of Pluripotency.
Cell-lineage-specific expression of the mouse hsp68 gene during embryogenesis.
Cellular HSP90 (HSP86) mRNA level and in vitro differentiation of mouse embryonal carcinoma (F9) cells.
Expression of the glucose-regulated proteins (GRP94 and GRP78) in differentiated and undifferentiated mouse embryonic cells and the use of the GRP78 promoter as an expression system in embryonic cells.
Function of 90-kDa heat shock protein in cellular differentiation of human embryonal carcinoma cells.
Heat shock protein synthesis in preimplantation mouse embryos and embryonal carcinoma cells.
Regulation of J6 gene expression by transcription factor GATA-4.
The small heat shock protein hsp25 is accumulated in P19 embryonal carcinoma cells and embryonic stem cells of line BLC6 during differentiation.
Unusual levels of heat shock element-binding activity in embryonal carcinoma cells.
Carcinoma, Endometrioid
GRP78 Mediates Cell Growth and Invasiveness in Endometrial Cancer.
Carcinoma, Hepatocellular
1,3,5-Trihydroxy-13,13-dimethyl-2H-pyran [7,6-b] xanthone directly targets heat shock protein 27 in hepatocellular carcinoma.
14-3-3? induces heat shock protein 70 expression in hepatocellular carcinoma.
15-Lipoxygenase-1/15-hydroxyeicosatetraenoic acid promotes hepatocellular cancer cells growth through protein kinase B and heat shock protein 90 complex activation.
17-Demethoxy-reblastatin, an Hsp90 inhibitor, induces mitochondria-mediated apoptosis through downregulation of Mcl-1 in human hepatocellular carcinoma cells.
A cellular factor stimulates ligand-dependent release of hsp90 from the basic helix-loop-helix dioxin receptor.
A heat-inducible nuclear factor that binds to the heat-shock element of the human haem oxygenase gene.
A novel cytoplasmic protein that interacts with the Ah receptor, contains tetratricopeptide repeat motifs, and augments the transcriptional response to 2,3,7,8-tetrachlorodibenzo-p-dioxin.
A Targetable Molecular Chaperone Hsp27 Confers Aggressiveness in Hepatocellular Carcinoma.
A unique P-glycoprotein interacting agent displays anticancer activity against hepatocellular carcinoma through inhibition of GRP78 and mTOR pathways.
Activation of heme oxygenase and heat shock protein 70 genes by stress in human hepatoma cells.
Activation of the ATF6, XBP1 and grp78 genes in human hepatocellular carcinoma: a possible involvement of the ER stress pathway in hepatocarcinogenesis.
ADP-ribosylation of the molecular chaperone GRP78/BiP.
Analysis of hsp70 mRNA levels in HepG2 cells exposed to various metals differing in toxicity.
Apoprotein B degradation is promoted by the molecular chaperones hsp90 and hsp70.
Application of Immunohistochemistry in the Pathological Diagnosis of Liver Tumors.
Attenuated phosphorylation of heat shock protein 27 correlates with tumor progression in patients with hepatocellular carcinoma.
Brefeldin A as a regulator of grp78 gene expression in mammalian cells.
C0818, a novel curcumin derivative, induces ROS-dependent cytotoxicity in human hepatocellular carcinoma cells in vitro via disruption of Hsp90 function.
Cell cycle regulation of the chicken hsp90 alpha expression.
Cell surface GRP78 facilitates hepatoma cells proliferation and migration by activating IGF-IR.
Chaperone action in the posttranslational topological reorientation of the hepatitis B virus large envelope protein: Implications for translocational regulation.
CHOP favors endoplasmic reticulum stress-induced apoptosis in hepatocellular carcinoma cells via inhibition of autophagy.
Clusterin Protects Hepatocellular Carcinoma Cells from Endoplasmic Reticulum Stress Induced Apoptosis through GRP78.
Co-localization of the heat shock protein and human immunoglobulin G in hepatocellular carcinoma.
Combination of HSP90 and autophagy inhibitors promotes hepatocellular carcinoma apoptosis following incomplete thermal ablation.
Combined use of heat-shock protein 70 and glutamine synthetase is useful in the distinction of typical hepatocellular adenoma from atypical hepatocellular neoplasms and well-differentiated hepatocellular carcinoma.
Comparative proteomics of rat liver and Morris hepatoma 7777 plasma membranes.
Complex Formation between Heat Shock Protein 72 and Hepatitis B Virus X Protein in Hepatocellular Carcinoma Tissues.
Complex formation between heat shock protein 72 and hepatitis B virus X protein in hepatocellular carcinoma tissues.
Concomitant overexpression of heat-shock protein 70 and HLA class-I in hepatitis C virus-related hepatocellular carcinoma.
Concomitant use of heat-shock protein 70, glutamine synthetase and glypican-3 is useful in diagnosis of HBV-related hepatocellular carcinoma with higher specificity and sensitivity.
Conformational Landscape of the PRKACA-DNAJB1 Chimeric Kinase, the Driver for Fibrolamellar Hepatocellular Carcinoma.
Correction to: Novel adjuvant dendritic cell therapy with transfection of heat-shock protein 70 messenger RNA for patients with hepatocellular carcinoma: a phase I/II prospective randomized controlled clinical trial.
Curcumin Upregulates Antioxidant Defense, Lon Protease, and Heat-Shock Protein 70 Under Hyperglycemic Conditions in Human Hepatoma Cells.
Cytoplasmic sequestration of the tumor suppressor p53 by a heat shock protein 70 family member, mortalin, in human colorectal adenocarcinoma cell lines.
Dendritic cells pulsed with Hsp70 and HBxAg induce specific antitumor immune responses in hepatitis B virus?associated hepatocellular carcinoma.
Dendritic cells transfected with heat-shock protein 70 messenger RNA for patients with hepatitis C virus-related hepatocellular carcinoma: a phase 1 dose escalation clinical trial.
Destabilization of PDK1 by Hsp90 inactivation suppresses hepatitis C virus replication through inhibition of PRK2-mediated viral RNA polymerase phosphorylation.
Development of human hepatocellular carcinoma cell-targeted protein cages.
Diagnostic Value of Glypican3, Heat Shock Protein 70 and Glutamine Synthetase in Hepatocellular Carcinoma Arising in Cirrhotic and Non-Cirrhotic Livers.
Differential proteomics identification of HSP90 as potential serum biomarker in hepatocellular carcinoma by two-dimensional electrophoresis and mass spectrometry.
Dinitrosyl iron complexes with thiol-containing ligands and S-nitroso-D,L-penicillamine as inductors of heat shock protein synthesis in H35 hepatoma cells.
Direct association of heat shock protein 20 (HSPB6) with phosphoinositide 3-kinase (PI3K) in human hepatocellular carcinoma: regulation of the PI3K activity.
Discovery of 5-aryl-3-thiophen-2-yl-1H-pyrazoles as a new class of Hsp90 inhibitors in hepatocellular carcinoma.
Down-modulation of heat shock protein 70 and up-modulation of Caspase-3 during schisandrin B-induced apoptosis in human hepatoma SMMC-7721 cells.
Dynamic expression of rat heat shock protein gp96 and its gene during development of hepatocellular carcinoma.
Effect of 5-aza-2'-deoxycytidine on immune-associated proteins in exosomes from hepatoma.
Effects of heat stress on the level of heat shock protein 70 on the surface of hepatocellular carcinoma Hep G2 cells: implications for the treatment of tumors.
Effects of HSP70 antisense oligonucleotide on the proliferation and apoptosis of human hepatocellular carcinoma cells.
Effects of the epigenetic drug MS-275 on the release and function of exosome-related immune molecules in hepatocellular carcinoma cells.
Elevated Mortalin correlates with poor outcome in hepatocellular carcinoma.
Enhanced antitumor effects of adenoviral-mediated siRNA against GRP78 gene on adenosine-induced apoptosis in human hepatoma HepG2 cells.
Ethanol facilitates HCV replication via upregulation of GW182 and HSP90 in human hepatoma cells.
Exogenous H2S promotes cancer progression by activating JAK2/STAT3 signaling pathway in esophageal EC109 cells.
Exosomes derived from siRNA against GRP78 modified bone-marrow-derived mesenchymal stem cells suppress Sorafenib resistance in hepatocellular carcinoma.
Exploiting bilosomes for delivering bioactive polysaccharide isolated from Enteromorpha intestinalis for hacking hepatocellular carcinoma.
Expression levels of heat shock protein 20 decrease in parallel with tumor progression in patients with hepatocellular carcinoma.
Expression of different members of heat shock protein 70 gene family in liver and hepatomas.
Expression of heat shock proteins (HSP27, HSP60, HSP70, HSP90, GRP78, GRP94) in hepatitis B virus-related hepatocellular carcinomas and dysplastic nodules.
Expression of mortalin detected in human liver cancer by tissue microarrays.
Extracellular HSP70-peptide complexes promote the proliferation of hepatocellular carcinoma cells via TLR2/4/JNK1/2MAPK pathway.
Extracellular HSP70/HSP70-PCs regulate hepatocarcinoma cell migration and invasion via RhoA.
Flavone antagonists bind competitively with 2,3,7, 8-tetrachlorodibenzo-p-dioxin (TCDD) to the aryl hydrocarbon receptor but inhibit nuclear uptake and transformation.
Gas generating microspheres for immediate release of Hsp90 inhibitor aiming at postembolization hypoxia in transarterial chemoembolization therapy of hepatocellular carcinoma.
Gel-based proteomics of liver cancer progression in rat.
Generation of murine CTL by a hepatitis B virus-specific peptide and evaluation of the adjuvant effect of heat shock protein glycoprotein 96 and its terminal fragments.
Genetic variants of heat shock protein A1L2437 and A1B1267 as possible risk factors for hepatocellular carcinoma in India.
Glucose regulated protein 78 promotes cell invasion via regulation of uPA production and secretion in colon cancer cells.
Glucose-Regulated Protein 78 (GRP78) Mediated the Efficacy to Curcumin Treatment on Hepatocellular Carcinoma.
Glucose-Regulated Protein 78 (GRP78) Silencing Enhances Cell Migration but Does Not Influence Cell Proliferation in Hepatocellular Carcinoma.
Glutamine Synthetase, Heat shock Protein-70, and Glypican-3 in Intrahepatic Cholangiocarcinoma and Tumors Metastatic to Liver.
Granulin-epithelin precursor interacts with 78-kDa glucose-regulated protein in hepatocellular carcinoma.
Growth factors acting via tyrosine kinase receptors induce HSP90 alpha gene expression.
GRP78 activates the Wnt/HOXB9 pathway to promote invasion and metastasis of hepatocellular carcinoma by chaperoning LRP6.
GRP78 and GAL3, differentially regulated by lymph node homogenates, as potential biomarkers for lymph node metastasis in mouse hepatocellular carcinoma cells.
GRP78 confers the resistance to 5-FU by activating the c-Src/LSF/TS axis in hepatocellular carcinoma.
GRP78 Promotes Hepatocellular Carcinoma proliferation by increasing FAT10 expression through the NF-?B pathway.
Grp78 promotes the invasion of hepatocellular carcinoma.
HBP21, a chaperone of heat shock protein 70, functions as a tumor suppressor in hepatocellular carcinoma.
Heat Shock Protein 12A Is a Novel PCNA-binding Protein and Promotes Hepatocellular Carcinoma Growth.
Heat shock protein 20 (HSPB6) regulates apoptosis in human hepatocellular carcinoma cells: Direct association with Bax.
Heat shock protein 20 (HSPB6) regulates TNF-?-induced intracellular signaling pathway in human hepatocellular carcinoma cells.
Heat shock protein 22 (HSPB8) reduces the migration of hepatocellular carcinoma cells through the suppression of the phosphoinositide 3-kinase (PI3K)/AKT pathway.
Heat shock protein 27 mediates the effect of 1,3,5-trihydroxy-13,13-dimethyl-2H-pyran [7,6-b] xanthone on mitochondrial apoptosis in hepatocellular carcinoma.
Heat Shock Protein 60 in Hepatocellular Carcinoma: Insights and Perspectives.
Heat shock protein 70 chaperoned alpha-fetoprotein in human hepatocellular carcinoma cell line BEL-7402.
Heat shock protein 70 downregulation inhibits proliferation, migration and tumorigenicity in hepatocellular carcinoma cells.
Heat shock protein 70 positively regulates transforming growth factor-?-induced hepatocellular carcinoma cell migration via the AKT signaling pathway.
Heat shock protein 70 serum levels differ significantly in patients with chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma.
Heat shock protein 70 silencing enhances apoptosis inducing factor-mediated cell death in hepatocellular carcinoma HepG(2) cells.
Heat shock protein 90 inhibition abrogates hepatocellular cancer growth through cdc2-mediated G(2)/M cell cycle arrest and apoptosis.
Heat shock protein 90 promotes RNA helicase DDX5 accumulation and exacerbates hepatocellular carcinoma by inhibiting autophagy.
Heat Shock Protein 90?-Dependent B-Cell-2-Associated Transcription Factor 1 Promotes Hepatocellular Carcinoma Proliferation by Regulating MYC Proto-Oncogene c-MYC mRNA Stability.
Heat Shock Protein A1B 1267 Polymorphism Is Highly Associated With Risk and Prognosis of Hepatocellular Carcinoma: A Case-Control Study.
Heat Shock Protein Beta 1 is a Prognostic Biomarker and Correlated with Immune Infiltrates in Hepatocellular Carcinoma.
Heat shock protein expression and autophagy after incomplete thermal ablation and their correlation.
Heat shock protein expression induced by percutaneous radiofrequency ablation of hepatocellular carcinoma in vivo.
Heat shock protein-guided dual-mode CT/MR imaging of orthotopic hepatocellular carcinoma tumor.
Heat shock, protein synthesis and ribosomal protein S6 phosphorylation in vitro in Yoshida AH 130 ascites hepatoma cells.
Hep88 mAb-initiated paraptosis-like PCD pathway in hepatocellular carcinoma cell line through the binding of mortalin (HSPA9) and alpha-enolase.
Hepatocellular carcinoma arising in adenoma: similar immunohistochemical and cytogenetic features in adenoma and hepatocellular carcinoma portions of the tumor.
Hepatoma cells adapted to proliferate under normally lethal hyperthermic stress conditions show rapid decay of thermoresistance and heat shock protein synthesis when returned to 37 degrees C.
Hsp27 Acts as a Master Molecular Chaperone and Plays an Essential Role in Hepatocellular Carcinoma Progression.
HSP27 expression levels are associated with the sensitivity of hepatocellular carcinoma cells to 17-allylamino-17-demethoxygeldanamycin.
Hsp60 exerts a tumor suppressor function by inducing cell differentiation and inhibiting invasion in hepatocellular carcinoma.
HSP90 and SIRT3 expression in hepatocellular carcinoma and their effect on invasive capability of human hepatocellular carcinoma cells.
Hsp90 inhibitor 17-AAG sensitizes Bcl-2 inhibitor (-)-gossypol by suppressing ERK-mediated protective autophagy and Mcl-1 accumulation in hepatocellular carcinoma cells.
Hsp90 inhibitor geldanamycin enhances the antitumor efficacy of enediyne lidamycin in association with reduced DNA damage repair.
Hsp90 Inhibitor STA9090 Sensitizes Hepatocellular Carcinoma to Hyperthermia-Induced DNA Damage by Suppressing DNA-PKcs Protein Stability and mRNA Transcription.
HSP90 inhibits apoptosis and promotes growth by regulating HIF-1? abundance in hepatocellular carcinoma.
HSP90 interacts with HMGCR and promotes the progression of hepatocellular carcinoma.
HSP90 promotes cell glycolysis, proliferation and inhibits apoptosis by regulating PKM2 abundance via Thr-328 phosphorylation in hepatocellular carcinoma.
HSP90? combined with AFP and TK1 improved the diagnostic value for hepatocellular carcinoma.
Human hepatoma cell line (HepG2) cellular response to hypothermic stress with recovery. Induction of Hsp70, Hsp60 and Hsf1 expression.
Hypoxia attenuates Hsp90 inhibitor 17-DMAG-induced cyclin B1 accumulation in hepatocellular carcinoma cells.
Hypoxia induces HSP 70 gene expression in human hepatoma (HEP G2) cells.
Identification of a Promiscuous Epitope Peptide Derived From HSP70.
Identification of Tumor Antigen AF20 as Glycosylated Transferrin Receptor 1 in Complex with Heat Shock Protein 90 and/or Transporting ATPase.
Immunoexpression of Heat Shock Protein 70, Glypican 3, Glutamine Synthetase, and Beta-Catenin in Hepatocellular Carcinoma After Liver Transplantation: Association Between Positive Glypican 3 and Beta-Catenin With the Presence of Larger Nodules.
In silico analysis of the binding properties of solasonine to mortalin and p53, and in vitro pharmacological studies of its apoptotic and cytotoxic effects on human HepG2 and Hep3b hepatocellular carcinoma cells.
Increase of thermoresistance after growth stimulation of resting Reuber H35 hepatoma cells. Alteration of nuclear characteristics, non-histone chromosomal protein phosphorylation and basal heat shock protein synthesis.
Increased expression of heat shock protein-binding protein 1 and heat shock protein 70 in human hepatocellular carcinoma tissues.
Induction of anoikis by sodium arsenite in rat hepatoma FGC4 cells: comparison with cadmium chloride and implications for assessment of regulation of heat shock protein 70.
Induction of mitochondrial chaperonin, hsp60, by cadmium in human hepatoma cells.
Induction of mutant p53-dependent apoptosis in human hepatocellular carcinoma by targeting stress protein mortalin.
Induction of plasminogen activator inhibitor 1 biosynthesis by hyperthermia.
Inhibition of Hsp27 and Hsp40 potentiates 5-fluorouracil and carboplatin mediated cell killing in hepatoma cells.
Insulin Dependant Gene Expression of Heat Shock Protein 60 in H4IIE Hepatoma Cells.
Interaction between heat shock protein 72 and alpha-fetoprotein in human hepatocellular carcinomas.
Interleukin 6 activates heat-shock protein 90 beta gene expression.
Intracellular association between UDP-glucose:glycoprotein glucosyltransferase and an incompletely folded variant of alpha1-antitrypsin.
Introducing differential expression of human heat shock protein 27 in hepatocellular carcinoma: moving toward identification of cancer biomarker.
Involvement and Targeted Intervention of Mortalin-Regulated Proteome Phosphorylated-Modification in Hepatocellular Carcinoma.
Involvement of heat-shock protein 70 and P53 proteins in attenuation of UVC-induced apoptosis by thermal stress in hepatocellular carcinoma cells.
Involvement of heat-shock protein 90 in the interleukin-6-mediated signaling pathway through STAT3.
Liver haploinsufficiency of RuvBL1 causes hepatic insulin resistance and enhances hepatocellular carcinoma progression.
Liver Reptin/RUVBL2 controls glucose and lipid metabolism with opposite actions on mTORC1 and mTORC2 signalling.
Molecular chaperone CCT3 supports proper mitotic progression and cell proliferation in hepatocellular carcinoma cells.
Mortalin stabilizes CD151-depedent tetraspanin-enriched microdomains and implicates in the progression of hepatocellular carcinoma.
Mortalin-p53 interaction in cancer cells is stress dependent and constitutes a selective target for cancer therapy.
Nanoparticles inhibit cancer cell invasion and enhance antitumor efficiency by targeted drug delivery via cell surface-related GRP78.
No association between the haplotypic block in the 3' UTR of GRP78 and risk of hepatocellular carcinoma.
Non-specific protein modifications by a phytochemical induce heat shock response for self-defense.
Novel adjuvant dendritic cell therapy with transfection of heat-shock protein 70 messenger RNA for patients with hepatocellular carcinoma: a phase I/II prospective randomized controlled clinical trial.
Novel celastrol derivatives inhibit the growth of hepatocellular carcinoma patient-derived xenografts.
Overexpression of heat shock protein HSP90AA1 and translocase of the outer mitochondrial membrane TOM34 in HCV-induced hepatocellular carcinoma: A pilot study.
Overexpression of Mortalin in hepatocellular carcinoma and its relationship with angiogenesis and epithelial to mesenchymal transition.
Phosphorylated Heat Shock Protein 20 (HSPB6) Regulates Transforming Growth Factor-?-Induced Migration and Invasion of Hepatocellular Carcinoma Cells.
Phosphorylated heat shock protein 27 represses growth of hepatocellular carcinoma via inhibition of extracellular signal-regulated kinase.
Prenylation differentially inhibits insulin-dependent immediate early gene mRNA expression.
Preventive and therapeutic effect of tumor derived heat shock protein, gp96, in an experimental prostate cancer model.
PRMT6 deficiency induces autophagy in hostile microenvironments of hepatocellular carcinoma tumors by regulating BAG5-associated HSC70 stability.
Prospective validation of an immunohistochemical panel (glypican 3, heat shock protein 70 and glutamine synthetase) in liver biopsies for diagnosis of very early hepatocellular carcinoma.
Protective Effects of Alisma orientale Extract against Hepatic Steatosis via Inhibition of Endoplasmic Reticulum Stress.
Protein kinase C delta regulates the phosphorylation of heat shock protein 27 in human hepatocellular carcinoma.
Proteomic Characterization of Annexin l (ANX1) and Heat Shock Protein 27 (HSP27) as Biomarkers for Invasive Hepatocellular Carcinoma Cells.
Proteomic Profile of Sorafenib Resistance in Hepatocellular Carcinoma; GRP78 Expression Is Associated With Inferior Response to Sorafenib.
Proteomic profiling of heat shock protein 70 family members as biomarkers for hepatitis C virus-related hepatocellular carcinoma.
Purification of heat shock protein 70-associated tumor peptides and their antitumor immunity to hepatoma in mice.
Regulation of HSP27 on NF-kappaB pathway activation may be involved in metastatic hepatocellular carcinoma cells apoptosis.
Regulation of Molecular Chaperone GRP78 by Hepatitis B Virus: Control of Viral Replication and Cell Survival.
Reversible ADP-ribosylation of the 78 kDa glucose-regulated protein.
Role of HSP90, CDC37, and CRM1 as modulators of P16(INK4A) activity in rat liver carcinogenesis and human liver cancer.
Role of the aryl hydrocarbon receptor nuclear translocator protein in aryl hydrocarbon (dioxin) receptor action.
Role of the novel HSP90 inhibitor AUY922 in hepatocellular carcinoma: Potential for therapy.
S-nitrosylation of the Mitochondrial Chaperone TRAP1 Sensitizes Hepatocellular Carcinoma Cells to Inhibitors of Succinate Dehydrogenase.
Serum heat shock protein 27 levels in patients with hepatocellular carcinoma.
Silencing of Glucose-Regulated Protein 78 (GRP78) Enhances Cell Migration Through the Upregulation of Vimentin in Hepatocellular Carcinoma Cells.
Single nucleotide polymorphism of rs430397 in the fifth intron of GRP78 gene and clinical relevance of primary hepatocellular carcinoma in Han Chinese: risk and prognosis.
Sinulariolide Induced Hepatocellular Carcinoma Apoptosis through Activation of Mitochondrial-Related Apoptotic and PERK/eIF2?/ATF4/CHOP Pathway.
Strategic shotgun proteomics approach for efficient construction of an expression map of targeted protein families in hepatoma cell lines.
Structural analyses of the PKA RII? holoenzyme containing the oncogenic DnaJB1-PKAc fusion protein reveal protomer asymmetry and fusion-induced allosteric perturbations in fibrolamellar hepatocellular carcinoma.
Suppression by heat shock protein 20 of hepatocellular carcinoma cell proliferation via inhibition of the mitogen-activated protein kinases and AKT pathways.
Targeted inhibition of mitochondrial Hsp90 induces mitochondrial elongation in Hep3B hepatocellular carcinoma cells undergoing apoptosis by increasing the ROS level.
Targeting GRP75 improves HSP90 inhibitor efficacy by enhancing p53-mediated apoptosis in hepatocellular carcinoma.
Targeting heat shock protein 90 with non-quinone inhibitors: A novel chemotherapeutic approach in human hepatocellular carcinoma.
Targeting heat-shock protein 90 improves efficacy of rapamycin in a model of hepatocellular carcinoma in mice.
Targeting HSP60 by subcutaneous injections of jetPEI/HSP60-shRNA destabilizes cytoplasmic survivin and inhibits hepatocellular carcinoma growth.
Targeting HSP90 with the small molecule inhibitor AUY922 (luminespib) as a treatment strategy against hepatocellular carcinoma.
The 3' UTR Variants in the GRP78 Are Not Associated with Overall Survival in Resectable Hepatocellular Carcinoma.
The anti-cancer flavonoid chrysin induces the unfolded protein response in hepatoma cells.
The apoptotic effect and associated signalling of HSP90 inhibitor 17-DMAG in hepatocellular carcinoma cells.
The association of variants in PNPLA3 and GRP78 and the risk of developing hepatocellular carcinoma in an Italian population.
The cell surface GRP78 facilitates the invasion of hepatocellular carcinoma cells.
The Clinical Value of HSP60 in Digestive System Cancers: a Systematic Review and Meta-Analysis.
The clinicopathological significance of heat shock protein 70 and glutamine synthetase expression in hepatocellular carcinoma.
The Escherichia coli Subtilase Cytotoxin A Subunit Specifically Cleaves Cell-Surface GRP78 and Abolishes COOH-Terminal-Dependent Signaling.
The Hsp90 inhibitor SNX-2112 induces apoptosis of human hepatocellular carcinoma cells: The role of ER stress.
The HSP90 inhibitor, XL888, enhanced cell apoptosis via downregulating STAT3 after insufficient radiofrequency ablation in hepatocellular carcinoma.
The ménage à trois of autophagy, lipid droplets and liver disease.
The role of c-Src in the invasion and metastasis of hepatocellular carcinoma cells induced by association of cell surface GRP78 with activated ?2M.
The role of heat shock protein 27 expression in hepatocellular carcinoma in Japan: special reference to the difference between hepatitis B and C.
The role of HSP90 molecular chaperones in hepatocellular carcinoma.
The role of inorganic metals and metalloporphyrins in the induction of haem oxygenase and heat-shock protein 70 in human hepatoma cells.
The rs391957 variant cis-regulating oncogene GRP78 expression contributes to the risk of hepatocellular carcinoma.
Tissue Biomarkers in Hepatocellular Tumors: Which, When, and How.
Transcriptional Enhancer Factor Domain Family member 4 Exerts an Oncogenic Role in Hepatocellular Carcinoma by Hippo-Independent Regulation of Heat Shock Protein 70 Family Members.
Transcriptional signaling from membrane raft-associated glucocorticoid receptor.
Transcriptomic analysis reveals that heat shock protein 90? is a potential diagnostic and prognostic biomarker for cancer.
Transcriptomic characterization of fibrolamellar hepatocellular carcinoma.
Tunicamycin induces resistance to camptothecin and etoposide in human hepatocellular carcinoma cells: role of cell-cycle arrest and GRP78.
Upregulation of heat shock protein 70 and the differential protein expression induced by tumor necrosis factor-alpha enhances migration and inhibits apoptosis of hepatocellular carcinoma cell HepG2.
Vorinostat suppresses hypoxia signaling by modulating nuclear translocation of hypoxia inducible factor 1 alpha.
[Construction of underexpression HSP90alpha and overexpression HSP90beta human hepatoma cell line HepG2].
[Inhibition of HSP70-2 expression by RNA interference induces apoptosis of human hepatocellular carcinoma cells.]
[Overexpression of heat shock protein 70 and spontaneous cancer cell apoptosis in hepatocellular carcinoma]
[Regulatory mechanism of heat shock protein 90 on autophagy-related transcription factor EB in human hepatocellular carcinoma cells].
[Relationship of heat shock protein 70-2 gene polymorphism with hepatocellular carcinoma]
[Stable isotope labeling and parallel reaction monitoring-based proteomic quantification for biomarker screening and validation of hepatocellular carcinoma].
[The detection of heat shock protein gp96 in primary hepatocellular carcinoma]
Carcinoma, Intraductal, Noninfiltrating
Elevated expression of nuclear Hsp90 in invasive breast tumors.
Heat shock protein 27 overexpression in breast cancer lymph node metastasis.
Hsp90 in the continuum of breast ductal carcinogenesis: Evaluation in precursors, preinvasive and ductal carcinoma lesions.
Proteomics-based identification of HSP60 as a tumor-associated antigen in early stage breast cancer and ductal carcinoma in situ.
Serum levels of HSP90 in the continuum of breast ductal and lobular lesions.
Systematic analyses of key genes and pathways in the development of invasive breast cancer.
The clinicopathological significance of Mortalin overexpression in invasive ductal carcinoma of breast.
Carcinoma, Lewis Lung
Effects of a Unique Combination of the Whole-Body Low Dose Radiotherapy with Inactivation of Two Immune Checkpoints and/or a Heat Shock Protein on the Transplantable Lung Cancer in Mice.
Heat shock protein 70 is acute phase reactant: response elicited by tumor treatment with photodynamic therapy.
The 650-kDa 12(S)-hydroxyeicosatetraenoic acid binding complex: occurrence in human platelets, identification of hsp90 as a constituent, and binding properties of its 50-kDa subunit.
Carcinoma, Lobular
BAG-1/SODD, HSP70 and HSP90 are potential prognostic markers of poor survival in node-negative breast carcinoma.
Decreased Hsp90 expression in infiltrative lobular carcinoma: an immunohistochemical study.
Heat shock protein 90 (hsp90) expression and breast cancer.
Serum levels of HSP90 in the continuum of breast ductal and lobular lesions.
Carcinoma, Non-Small-Cell Lung
19P Comparative effectiveness analysis of HSP90 inhibitors in non-small cell lung cancer.
A new tumor suppressor DnaJ-like heat shock protein, HLJ1, and survival of patients with non-small-cell lung carcinoma.
A randomized phase II study of ganetespib, a heat shock protein 90 inhibitor, in combination with docetaxel in second-line therapy of advanced non-small cell lung cancer (GALAXY-1).
A Randomized, Double-Blinded, Phase II Trial of Carboplatin and Pemetrexed with or without Apatorsen (OGX-427) in Patients with Previously Untreated Stage IV Non-Squamous-Non-Small-Cell Lung Cancer: The SPRUCE Trial.
Anti-tumor selectivity of a novel tubulin and HSP90 dual-targeting inhibitor in non-small cell lung cancer models.
Antibodies to HSP70 and HSP90 in serum in non-small cell lung cancer patients.
Antibody Targeting GRP78 Enhances the Efficacy of Radiation Therapy in Human Glioblastoma and Non-Small Cell Lung Cancer Cell Lines and Tumor Models.
Argpyrimidine-modified Heat shock protein 27 in human non-small cell lung cancer: a possible mechanism for evasion of apoptosis.
Aspirin potentiates celecoxib-induced growth inhibition and apoptosis in human non-small cell lung cancer by targeting GRP78 activity.
Author Correction: Targeting Hsp90 with FS-108 circumvents gefitinib resistance in EGFR mutant non-small cell lung cancer cells.
Cancer-associated fibroblasts promote non-small cell lung cancer cell invasion by upregulation of glucose-regulated protein 78 (GRP78) expression in an integrated bionic microfluidic device.
Celastrol induces apoptosis in gefitinib-resistant non-small cell lung cancer cells via caspases-dependent pathways and Hsp90 client protein degradation.
Chalcone-templated Hsp90 inhibitors and their effects on gefitinib resistance in non-small cell lung cancer (NSCLC).
Circulating heat shock protein 27 as a biomarker for the differentiation of patients with lung cancer and healthy controls--a clinical comparison of different enzyme linked immunosorbent assays.
Clinicopathological and prognostic significance of heat shock protein 27 (HSP27) expression in non-small cell lung cancer: a systematic review and meta-analysis.
Combination of heat shock protein 90 and focal adhesion kinase inhibitors synergistically inhibits the growth of non-small cell lung cancer cells.
Complex Crystal Structure Determination and in vitro Anti-non-small Cell Lung Cancer Activity of Hsp90 N Inhibitor SNX-2112.
Correlation of Hsp70 Serum Levels with Gross Tumor Volume and Composition of Lymphocyte Subpopulations in Patients with Squamous Cell and Adeno Non-Small Cell Lung Cancer.
Development of a novel Hsp90 inhibitor NCT-50 as a potential anticancer agent for the treatment of non-small cell lung cancer.
Discovery of 2',4'-dimethoxychalcone as a Hsp90 inhibitor and its effect on iressa-resistant non-small cell lung cancer (NSCLC).
Discovery of hybrid Hsp90 inhibitors and their anti-neoplastic effects against gefitinib-resistant non-small cell lung cancer (NSCLC).
Distinct prognostic roles of HSPB1 expression in non-small cell lung cancer.
Down-regulation of ERK1/2 and AKT-mediated X-ray repair cross-complement group 1 protein (XRCC1) expression by Hsp90 inhibition enhances the gefitinib-induced cytotoxicity in human lung cancer cells.
Down-regulation of MSH2 expression by an Hsp90 inhibitor enhances pemetrexed-induced cytotoxicity in human non-small-cell lung cancer cells.
Drug-Like Small Molecule HSP27 Functional Inhibitor Sensitizes Lung Cancer Cells to Gefitinib or Cisplatin by Inducing Altered Cross-Linked Hsp27 Dimers.
Effect of BIS depletion on HSF1-dependent transcriptional activation in A549 non-small cell lung cancer cells.
EML4-ALK fusions: propelling cancer but creating exploitable chaperone dependence.
Emphasizing on heat shock protein 90's utility in head and neck squamous cell carcinoma treatment.
Ex vivo Hsp70-Activated NK Cells in Combination With PD-1 Inhibition Significantly Increase Overall Survival in Preclinical Models of Glioblastoma and Lung Cancer.
Expression of heat shock protein 70 and 27 in non-small cell lung cancer and its clinical significance.
Expressions of GRP78 and Bax associate with differentiation, metastasis, and apoptosis in non-small cell lung cancer.
Ganetespib (STA-9090), a Nongeldanamycin HSP90 Inhibitor, Has Potent Antitumor Activity in In Vitro and In Vivo Models of Non-Small Cell Lung Cancer.
GRP78 and Raf-1 cooperatively confer resistance to endoplasmic reticulum stress-induced apoptosis.
GRP78, intronic polymorphisms, and pharmacogenomics in non-small cell lung cancer.
Heat Shock Protein 70 (Hsp70) Peptide Activated Natural Killer (NK) Cells for the Treatment of Patients with Non-Small Cell Lung Cancer (NSCLC) after Radiochemotherapy (RCTx) - From Preclinical Studies to a Clinical Phase II Trial.
Heat shock protein 70 as a predictive marker for platinum-based adjuvant chemotherapy in patients with resected non-small cell lung cancer.
Heat shock protein 72 does not modulate ionizing radiation-induced apoptosis in U1810 non-small cell lung carcinoma cells.
Heat Shock Protein 90 (Hsp90) inhibitor occupancy is a direct determinant of client protein degradation and tumor growth arrest in vivo.
Heat shock protein antagonists in early stage clinical trials for NSCLC.
Heat shock protein B6 potently increases non-small cell lung cancer growth.
Heat Shock Proteins: A Potential Anticancer Target.
HLJ1 is a novel caspase-3 substrate and its expression enhances UV-induced apoptosis in non-small cell lung carcinoma.
HSP90 inhibition enhances antimitotic drug-induced mitotic arrest and cell death in preclinical models of non-small cell lung cancer.
HSP90 inhibition induces cytotoxicity via down-regulation of Rad51 expression and DNA repair capacity in non-small cell lung cancer cells.
Hsp90 Inhibitor Ganetespib Sensitizes Non-Small Cell Lung Cancer to Radiation but Has Variable Effects with Chemoradiation.
HSP90 inhibitor, DMAG, synergizes with radiation of lung cancer cells by interfering with base excision and ATM-mediated DNA repair.
Hsp90 inhibitors enhance the antitumoral effect of osimertinib in parental and osimertinib-resistant non-small cell lung cancer cell lines.
HSPB1 Gene Polymorphisms Predict Risk of Mortality for US Patients After Radio(chemo)therapy for Non-Small Cell Lung Cancer.
Integration of Gene Dosage and Gene Expression in Non-Small Cell Lung Cancer, Identification of HSP90 as Potential Target.
Involvement of calcium in the differential induction of heat shock protein 70 by heat shock protein 90 inhibitors, geldanamycin and radicicol, in human non-small cell lung cancer H460 cells.
Liposomal encapsulation of deguelin: evidence for enhanced antitumor activity in tobacco carcinogen-induced and oncogenic K-ras-induced lung tumorigenesis.
Luminespib plus pemetrexed in patients with non-squamous non-small cell lung cancer.
Molecular Chaperone HSP90 Is Necessary to Prevent Cellular Senescence via Lysosomal Degradation of p14ARF.
Mortalin overexpression predicts poor prognosis in early stage of non-small cell lung cancer.
Novel Heat Shock Protein 90 Inhibitors Suppress P-Glycoprotein Activity and Overcome Multidrug Resistance in Cancer Cells.
Novel Hsp90 Inhibitor C086 Potently Inhibits Non-Small Cell Lung Cancer Cells As A Single Agent Or In Combination With Gefitinib.
Nuclear Accumulation of Heat-shock Protein 90 Is Associated with Poor Survival and Metastasis in Patients with Non-small Cell Lung Cancer.
Overexpression of HSP10 correlates with HSP60 and Mcl-1 levels and predicts poor prognosis in non-small cell lung cancer patients.
P-glycoprotein confers acquired resistance to 17-DMAG in lung cancers with an ALK rearrangement.
Pifithrin-? is efficacious against non-small cell lung cancer via inhibition of heat shock protein 70.
Prognostic value of the mRNA expression of members of the HSP90 family in non-small cell lung cancer.
Reversed expression of GRIM-1 and GRP78 in human non-small cell lung cancer.
Sensitization of lung cancer cells by altered dimerization of HSP27.
Serum GRP78 as a Tumor Marker and Its Prognostic Significance in Non-Small Cell Lung Cancers: A Retrospective Study.
Strong anti-tumor effect of NVP-AUY922, a novel Hsp90 inhibitor, on non-small cell lung cancer.
Synergistic activity of the Hsp90 inhibitor ganetespib with taxanes in non-small cell lung cancer models.
Targeted Inhibition of the Molecular Chaperone Hsp90 Overcomes ALK Inhibitor Resistance in Non-Small Cell Lung Cancer.
Targeting heat shock protein 90 with CUDC-305 overcomes erlotinib resistance in non-small cell lung cancer.
Targeting Hsp90 with FS-108 circumvents gefitinib resistance in EGFR mutant non-small cell lung cancer cells.
Targeting KRAS-mutant non-small cell lung cancer with the Hsp90 inhibitor ganetespib.
The anti-cancer drug ABTL0812 induces ER stress-mediated cytotoxic autophagy by increasing dihydroceramide levels in cancer cells.
The heat shock protein 90 inhibitor, AT13387, displays a long duration of action in vitro and in vivo in non-small cell lung cancer.
The HSP90 inhibitor ganetespib potentiates the antitumor activity of EGFR tyrosine kinase inhibition in mutant and wild-type non-small cell lung cancer.
The Hsp90 inhibitor IPI-504 rapidly lowers EML4-ALK levels and induces tumor regression in ALK-driven NSCLC models.
The HSP90 inhibitor NVP-AUY922 potently inhibits non-small cell lung cancer growth.
The HSP90 inhibitor, NVP-AUY922, attenuates intrinsic PI3K inhibitor resistance in KRAS-mutant non-small cell lung cancer.
The HSP90 inhibitor, NVP-AUY922, sensitizes KRAS-mutant non-small cell lung cancer with intrinsic resistance to MEK inhibitor, trametinib.
Therapeutic uses of HSP90 inhibitors in Non-Small Cell Lung Carcinoma (NSCLC).
Tumor suppressor HLJ1 binds and functionally alters nucleophosmin via activating enhancer binding protein 2alpha complex formation.
Tumor-Intrinsic and Tumor-Extrinsic Factors Impacting Hsp90-Targeted Therapy.
[Relationship between chemosensitivity in vitro and the expression of GRP78 in non-small cell lung cancer.]
Carcinoma, Ovarian Epithelial
18?-Glycyrrhetinic acid potentiates Hsp90 inhibition-induced apoptosis in human epithelial ovarian carcinoma cells via activation of death receptor and mitochondrial pathway.
Combined Effect of Hsp90 Inhibitor Geldanamycin and Parthenolide via Reactive Oxygen Species-Mediated Apoptotic Process on Epithelial Ovarian Cancer Cells.
Expression of heat-shock proteins hsp27, hsp70 and hsp90 in malignant epithelial tumour of the ovaries.
Heat shock protein 27: a potential biomarker of peritoneal metastasis in epithelial ovarian cancer?
Heat shock protein 27: an independent prognostic indicator of survival in patients with epithelial ovarian carcinoma.
HSPA1A, HSPA1L and TRAP1 heat shock genes may be associated with prognosis in ovarian epithelial cancer.
Immunohistochemical detection of HSP60-expression in human ovarian cancer. Correlation with survival in a series of 247 patients.
Increased expression of heat shock protein 27 correlates with peritoneal metastasis in epithelial ovarian cancer.
Inhibition of Heat Shock Protein 90 suppresses TWIST1 Transcription.
Overexpression of GRP78 is associated with malignant transformation in epithelial ovarian tumors.
Papers to Appear in Forthcoming Issues
Quantitative assessment of serum heat shock protein 27 for the diagnosis of epithelial ovarian cancer using targeted proteomics coupled with immunoaffinity enrichment.
Radicicol, an inhibitor of Hsp90, enhances TRAIL-induced apoptosis in human epithelial ovarian carcinoma cells by promoting activation of apoptosis-related proteins.
[Isolation, identification and clinical significance of ascites-derived exosomes from patients with ovarian epithelial cancer]
Carcinoma, Renal Cell
A hsp70-2 mutation recognized by CTL on a human renal cell carcinoma.
A phase II trial of 17-(Allylamino)-17-demethoxygeldanamycin in patients with papillary and clear cell renal cell carcinoma.
Characterization of heat shock protein 27 phosphorylation sites in renal cell carcinoma.
Clinical Implications of HSC70 Expression in Clear Cell Renal Cell Carcinoma.
Combination Treatment of Renal Cell Carcinoma with Belinostat and 5-Fluorouracil: A Role for Oxidative Stress Induced DNA Damage and HSP90 Regulated Thymidine Synthase.
Comparative analysis of novel and conventional Hsp90 inhibitors on HIF activity and angiogenic potential in clear cell renal cell carcinoma: implications for clinical evaluation.
Downregulation of HSP60 disrupts mitochondrial proteostasis to promote tumorigenesis and progression in clear cell renal cell carcinoma.
Downregulation of the tumor suppressor HSPB7, involved in the p53 pathway, in renal cell carcinoma by hypermethylation.
Effects of the novel heat shock protein 90 inhibitor AUY922 in renal cell carcinoma ACHN and 786-O cells.
EIF3D promotes sunitinib resistance of renal cell carcinoma by interacting with GRP78 and inhibiting its degradation.
Evaluation of renal cell carcinoma vaccines targeting carbonic anhydrase IX using heat shock protein 110.
Expression of heat shock protein 27 in human renal cell carcinoma.
Expression of heat shock protein 70 in renal cell carcinoma and its relation to tumor progression and prognosis.
Expression of heat shock protein 72 in renal cell carcinoma: possible role and prognostic implications in cancer patients.
GRP78 expression in tumor and perinephric adipose tissue is not an optimal risk stratification marker for clear cell renal cell carcinoma.
Heat shock protein (HSP72) surface expression enhances the lysis of a human renal cell carcinoma by IL-2 stimulated NK cells.
Heat shock protein expression and anti-heat shock protein reactivity in renal cell carcinoma.
Heat-shock protein 70 as a tumor antigen for in vitro dendritic cell pulsing in renal cell carcinoma cases.
HSP DNAJB8 controls tumor-initiating ability in renal cancer stem-like cells.
HSP60 silencing promotes Warburg-like phenotypes and switches the mitochondrial function from ATP production to biosynthesis in ccRCC cells.
Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1 alpha-degradative pathway.
Inhibition of Cancer Cell Growth by GRP78 siRNA Lipoplex via Activation of Unfolded Protein Response.
Inhibition of endoplasmic reticulum chaperone protein glucose-regulated protein 78 potentiates anti-angiogenic therapy in renal cell carcinoma through inactivation of the PERK/eIF2? pathway.
MicroRNA-30a-5p Inhibits the Growth of Renal Cell Carcinoma by Modulating GRP78 Expression.
Mps1 Mediated Phosphorylation of Hsp90 Confers Renal Cell Carcinoma Sensitivity and Selectivity to Hsp90 Inhibitors.
Quality of life in patients with metastatic renal cell carcinoma participating in a phase I trial of an autologous tumor-derived vaccine.
Quantitative score modulation of HSP90 and HSP27 in clear cell renal cell carcinoma.
Significance of heat shock protein-27 expression in patients with renal cell carcinoma.
Single-Cell Sequencing to Identify Six Heat Shock Protein (HSP) Genes-Mediated Progression Subtypes of Clear Cell Renal Cell Carcinoma.
Upregulation of GRP78 in Renal Cell Carcinoma and Its Significance.
[Generation of specific cytotoxicity T lymphocytes induced by tumor-derived heat shock protein 90-peptide complexes in vitro]
Carcinoma, Squamous Cell
A comparison of cell survival and heat shock protein expression after radiation in normal dermal fibroblasts, microvascular endothelial cells, and different head and neck squamous carcinoma cell lines.
A novel intronic circular RNA, circGNG7, inhibits head and neck squamous cell carcinoma progression by blocking the phosphorylation of heat shock protein 27 at Ser78 and Ser82.
Analysis of HSP90 Expression Is Valuable in the Differential Diagnosis of Ocular Surface Squamous Lesions.
Antitumorigenic Effect of Hsp90 Inhibitor SNX-2112 on Tongue Squamous Cell Carcinoma is Enhanced by Low-Intensity Ultrasound.
BIIB021, a novel HSP90 inhibitor, sensitizes head and neck squamous cell carcinoma to radiotherapy.
CD1A-positive cells and HSP60 (HSPD1) levels in keratoacanthoma and squamous cell carcinoma.
Cell surface expression of 70 kDa heat shock protein in human oral dysplasia and squamous cell carcinoma: correlation with clinicopathological features.
Chaperone-Mediated Autophagy Markers LAMP2A and HSC70 Are Independent Adverse Prognostic Markers in Primary Resected Squamous Cell Carcinomas of the Lung.
Chaperonin (HSP60) and annexin-2 are candidate biomarkers for non-small cell lung carcinoma.
Characterization of proteins associated with heat shock protein hsp27 in the squamous cell carcinoma cell line A431.
Co-overexpression of Bag-1 and heat shock protein 70 in human epidermal squamous cell carcinoma: Bag-1-mediated resistance to 5-fluorouracil-induced apoptosis.
Diagnostic value of heat shock protein 90? and squamous cell carcinoma antigen in detection of cervical cancer.
Differential expression of heat shock protein 27 in normal oral mucosa, oral epithelial dysplasia and squamous cell carcinoma.
Differential Expression of Heat Shock Protein 27 in Oral Epithelial Dysplasias and Squamous Cell Carcinoma.
Differential expression of Mr 70,000 heat shock protein in normal, premalignant, and malignant human uterine cervix.
Down-regulation of epidermal growth factor receptor-signaling pathway by binding of GRP78/BiP to the receptor under glucose-starved stress conditions.
Dysregulation of heat shock protein 27 expression in oral tongue squamous cell carcinoma.
Effect of 17-allylamino-17-demethoxygeldanamycin (17-AAG) on Akt protein expression is more effective in head and neck cancer cell lineages that retain PTEN protein expression.
Effect of hypoxia on the expression of alphaB-crystallin in head and neck squamous cell carcinoma.
Effects of a heat shock protein inhibitor KNK437 on heat sensitivity and heat tolerance in human squamous cell carcinoma cell lines differing in p53 status.
Effects of far infrared radiation by isotropic high-density carbon on the human oral mucosa.
Emphasizing on heat shock protein 90's utility in head and neck squamous cell carcinoma treatment.
Expression of ER stress and autophagy-related molecules in human non-small cell lung cancer and premalignant lesions.
Expression of Heat Shock Protein 105 in Cutaneous Squamous Cell Carcinoma: Correlation with Clinicopathological Characteristics.
Expression of heat shock proteins in squamous cell carcinoma of the tongue: an immunohistochemical study.
GRP78 induction by calcium ionophore potentiates photodynamic therapy using the mitochondrial targeting dye victoria blue BO.
Heat shock protein 105 is overexpressed in squamous cell carcinoma and extramammary Paget disease but not in basal cell carcinoma.
Heat shock protein 27 and p16 immunohistochemistry in cervical intraepithelial neoplasia and squamous cell carcinoma.
Heat Shock Protein 27 as a New Therapeutic Target for Radiation Sensitization of Head and Neck Squamous Cell Carcinoma.
Heat shock protein 70 and tumor-infiltrating NK cells as prognostic indicators for patients with squamous cell carcinoma of the head and neck after radiochemotherapy: A multicentre retrospective study of the German Cancer Consortium Radiation Oncology Group (DKTK-ROG).
Heat shock protein 70 is involved in malignant behaviors and chemosensitivities to cisplatin in cervical squamous cell carcinoma cells.
Heat shock protein 90 inhibitor 17-allylamino-17-demethoxygeldanamycin potentiates the radiation response of tumor cells grown as monolayer cultures and spheroids by inducing apoptosis.
Heat shock protein and p53 expression in head and neck squamous cell carcinoma.
Heat shock protein expression in oral epithelial dysplasia and squamous cell carcinoma.
High glucose uptake unexpectedly is accompanied by high levels of the mitochondrial ß-F1-ATPase subunit in head and neck squamous cell carcinoma.
HSP70: a promising target for laryngeal carcinoma radiaotherapy by inhibiting cleavage and degradation of nucleolin.
Hsp90 inhibitor can inhibit UV carcinogenesis.
HSP90 Inhibitor SNX5422/2112 Targets the Dysregulated Signal and Transcription Factor Network and Malignant Phenotype of Head and Neck Squamous Cell Carcinoma.
Hsp90 inhibitors cause G2/M arrest associated with the reduction of Cdc25C and Cdc2 in lung cancer cell lines.
Hsp90 is expressed and represents a therapeutic target in human oesophageal cancer using the inhibitor 17-allylamino-17-demethoxygeldanamycin.
Induction of heat shock protein 70 inhibits NF-kappa-B in squamous cell carcinoma.
Induction of the 72-kD heat shock protein in human skin melanoma and squamous cell carcinoma cell lines.
Molecular imaging of EGFR and CD44v6 for prediction and response monitoring of HSP90 inhibition in an in vivo squamous cell carcinoma model.
mRNA levels of molecular chaperones hsp27, hsp60 and hsp70 in cisplatin resistant squamous cell carcinomas.
Novel C-Terminal Heat Shock Protein 90 Inhibitors (KU711 and Ku757) Are Effective in Targeting Head and Neck Squamous Cell Carcinoma Cancer Stem cells.
Novel HSP90 Inhibitor NVP-AUY922 enhances the anti-tumor effect of temsirolimus against oral squamous cell carcinoma.
Overexpression of endoplasmic reticulum stress-related proteins, XBP1s and GRP78, predicts poor prognosis in pulmonary adenocarcinoma.
Overexpression of heat shock protein 27 in squamous cell carcinoma of the uterine cervix.
Overexpression of heat shock protein 27 in squamous cell carcinoma of the uterine cervix: a proteomic analysis using archival formalin-fixed, paraffin-embedded tissues.
Overexpression of the small heat shock protein, hsp27, confers resistance to hyperthermia, but not to oxidative stress and UV-induced cell death, in a stably transfected squamous cell carcinoma cell line.
Pharmacological Inhibition of HSP90 Radiosensitizes Head and Neck Squamous Cell Carcinoma Xenograft by Inhibition of DNA Damage Repair, Nucleotide Metabolism, and Radiation-Induced Tumor Vasculogenesis.
Potent activity of a novel dimeric heat shock protein 90 inhibitor against head and neck squamous cell carcinoma in vitro and in vivo.
Promoter hypermethylation of the gene encoding heat shock protein B1 in oral squamous carcinoma cells.
Protein Expression Profile using Two-Dimensional Gel Analysis in Squamous Cervical Cancer Patients.
Serum antibody response to the heat shock protein 60 of Chlamydia trachomatis in women with developing cervical cancer.
Sulfoxythiocarbamate S-4 inhibits HSP90 in human cutaneous squamous cell carcinoma cells.
The novel HSP90 inhibitor AT13387 potentiates radiation effects in squamous cell carcinoma and adenocarcinoma cells.
The release of Hsp70 from A431 carcinoma cells is mediated by secretory-like granules.
The selective Hsp90 inhibitor BJ-B11 exhibits potent antitumor activity via induction of cell cycle arrest, apoptosis and autophagy in Eca-109 human esophageal squamous carcinoma cells.
Topically Applied Hsp90 Inhibitor 17AAG Inhibits UVR-Induced Cutaneous Squamous Cell Carcinomas.
Triple knockdown of CDC37, HSP90-alpha and HSP90-beta diminishes extracellular vesicles-driven malignancy events and macrophage M2 polarization in oral cancer.
Two-dimensional gel analysis of protein expression profile in squamous cervical cancer patients.
[Biology behavior of head and neck squamous cell cancer cells changes after knocking down heat shock protein 27].
[Influence of the expression of heat shock protein 70 in maxillofacial squamous cell carcinoma by thermochemotherapy]
[Screening of differentially expressed proteins from human esophageal cancer and esophageal tissues by two-dimensional difference gel electrophoresis and mass spectrometry]
Carcinoma, Transitional Cell
Heat shock protein 70 expression in relation to apoptosis in primary bladder transitional cell carcinoma.
Heat shock proteins HSP27, HSP60, HSP70, and HSP90: expression in bladder carcinoma.
Hsp-27 has no diagnostic or prognostic significance in prostate or bladder cancers.
Carcinoma, Verrucous
Expression of p53, MDM2, p21, heat shock protein 70, and HPV 16/18 E6 proteins in oral verrucous carcinoma and oral verrucous hyperplasia.
Cardio-Renal Syndrome
Interrelationship between cardiac hypertrophy, heart failure, and chronic kidney disease: endoplasmic reticulum stress as a mediator of pathogenesis.
Cardiomegaly
A redox-dependent pathway for regulating class II HDACs and cardiac hypertrophy.
Activation of histone deacetylase 2 by inducible heat shock protein 70 in cardiac hypertrophy.
Class III PI3K-mediated prolonged activation of autophagy plays a critical role in the transition of cardiac hypertrophy to heart failure.
Difluoromethylornithine attenuates isoproterenol-induced cardiac hypertrophy by regulating apoptosis, autophagy and the mitochondria-associated membranes pathway.
Extracellular heat shock protein HSC70 protects against lipopolysaccharide-induced hypertrophic responses in rat cardiomyocytes.
GRP78 (Glucose-Regulated Protein of 78 kDa) Promotes Cardiomyocyte Growth Through Activation of GATA4 (GATA-Binding Protein 4).
Heat shock protein 90 regulates I?B kinase complex and NF-?B activation in angiotensin II-induced cardiac cell hypertrophy.
Heat-shock protein 90 modulates cardiac ventricular hypertrophy via activation of MAPK pathway.
HSP27 locus cosegregates with left ventricular mass independently of blood pressure.
Hsp90/Cdc37 assembly modulates TGF? receptor-II to act as a profibrotic regulator of TGF? signaling during cardiac hypertrophy.
Inhibition of heat shock protein 70 blocks the development of cardiac hypertrophy by modulating the phosphorylation of histone deacetylase 2.
Intracellular or extracellular heat shock protein 70 differentially regulates cardiac remodelling in pressure overload mice.
L-arginine restores endothelial nitric oxide synthase coupled activity and attenuates monocrotaline-induced pulmonary artery hypertension in rats.
Mitochondrial biogenesis during pressure overload induced cardiac hypertrophy in adult rats.
Myocyte-Derived Hsp90 Modulates Collagen Upregulation via Biphasic Activation of STAT-3 in Fibroblasts during Cardiac Hypertrophy.
PARM-1 is an endoplasmic reticulum molecule involved in endoplasmic reticulum stress-induced apoptosis in rat cardiac myocytes.
Small heat shock protein 20 (Hsp20) facilitates nuclear import of protein kinase D 1 (PKD1) during cardiac hypertrophy.
Small heat shock protein 20 (HspB6) in cardiac hypertrophy and failure.
Upregulation of autophagy genes and the unfolded protein response in human heart failure.
[Exercise preconditioning attenuates pressure overload-induced pathological cardiac hypertrophy: potential role of HSF1 and NF-?B p65 signaling].
[Progress in research on heat shock proteins in cardiovascular system]
Cardiomyopathies
?B-crystallin is a sensor for assembly intermediates and for the subunit topology of desmin intermediate filaments.
CaMKII activation participates in doxorubicin cardiotoxicity and is attenuated by moderate GRP78 overexpression.
Carnitine promotes heat shock protein synthesis in adriamycin-induced cardiomyopathy in a neonatal rat experimental model.
Class III PI3K-mediated prolonged activation of autophagy plays a critical role in the transition of cardiac hypertrophy to heart failure.
Desmin-related cardiomyopathy in transgenic mice: a cardiac amyloidosis.
Direct and Indirect Involvement of MicroRNA-499 in Clinical and Experimental Cardiomyopathy.
Evaluation of the effect of heat shock protein 70 targeted drugs on cirrhotic cardiomyopathy in biliary cirrhotic rats.
Evidence for a functional role of the molecular chaperone clusterin in amyloidotic cardiomyopathy.
Global expression profiling identifies a novel biosignature for protein aggregation R120GCryAB cardiomyopathy in mice.
Heat shock protein 70 expression protects against sepsis-associated cardiomyopathy by inhibiting autophagy.
Heat stress in rat adriamycin cardiomyopathy: heat shock protein 25 and Myosin accumulation.
High-mobility group box 1-mediated heat shock protein beta 1 expression attenuates mitochondrial dysfunction and apoptosis.
Hsp90 and its co-chaperone, Sgt1, as autoantigens in dilated cardiomyopathy.
Increased expression of 78 kD glucose-regulated protein promotes cardiomyocyte apoptosis in a rat model of liver cirrhosis.
Involvement of Reductive Stress in the Cardiomyopathy in Transgenic Mice With Cardiac-Specific Overexpression of Heat Shock Protein 27.
Mitochondrial dysfunction and apoptosis underlie the pathogenic process in alpha-B-crystallin desmin-related cardiomyopathy.
Multi-tissue analysis of co-expression networks by higher-order generalized singular value decomposition identifies functionally coherent transcriptional modules.
Phenotype of Cardiomyopathy in Cardiac-specific Heat Shock Protein B8 K141N Transgenic Mouse.
Probenecid treatment improves outcomes in a novel mouse model of peripartum cardiomyopathy.
Protective effect of geranylgeranylacetone via enhancement of HSPB8 induction in desmin-related cardiomyopathy.
Proteomic analysis reveals significant elevation of heat shock protein 70 in patients with chronic heart failure due to arrhythmogenic right ventricular cardiomyopathy.
The Human 343delT HSPB5 Chaperone Associated with Early-onset Skeletal Myopathy Causes Defects in Protein Solubility.
The protective effect of heat shock protein 70 (Hsp70) in atrial fibrillation in various cardiomyopathy conditions.
Cardiomyopathy, Alcoholic
Atorvastatin reduces alcohol-induced endoplasmic reticulum stress in AC16 cardiomyocytes.
Cardiomyopathy, Dilated
A crucial role of mitochondrial Hsp40 in preventing dilated cardiomyopathy.
Antibodies against stress proteins in sera of patients with dilated cardiomyopathy.
Deletion of heat shock protein 60 in adult mouse cardiomyocytes perturbs mitochondrial protein homeostasis and causes heart failure.
Dilated Cardiomyopathy (DCM)-linked Heat shock protein Family D Member 1 (HSPD1) mutations cause upregulation of ROS and autophagy through mitochondrial dysfunction.
Heat shock protein 25-enriched plasma transfusion preconditions the heart against doxorubicin-induced dilated cardiomyopathy in mice.
Hsp90 and its co-chaperone, Sgt1, as autoantigens in dilated cardiomyopathy.
Molecular chaperone, HSP60, and cytochrome P450 2E1 co-expression in dilated cardiomyopathy.
Refined purification of large amounts of Rat cvHsp/HspB7 and partial biological characterization in vitro.
The expression of heat shock protein 60 in patients with dilated cardiomyopathy.
[Effects of Mongolian new medicine-? on cardiac functions, endoplasmic reticulum stress and apoptosis in congestive heart failure rats with dilated cardiomyopathy].
Cardiomyopathy, Hypertrophic
Substantial decrease of heat shock protein 90 in ventricular tissues of two sudden-death pigs with hypertrophic cardiomyopathy.
Cardiotoxicity
Aptamer-Peptide Conjugates as Targeted Chemosensitizers for Breast Cancer Treatment.
Atrazine-xenobiotic nuclear receptor interactions induce cardiac inflammation and endoplasmic reticulum stress in quail (Coturnix coturnix coturnix).
CaMKII activation participates in doxorubicin cardiotoxicity and is attenuated by moderate GRP78 overexpression.
Cardiomyocyte Stim1 Deficiency Exacerbates Doxorubicin Cardiotoxicity by Magnification of Endoplasmic Reticulum Stress.
Doxorubicin-induced cardiotoxicity: direct correlation of cardiac fibroblast and H9c2 cell survival and aconitase activity with heat shock protein 27.
Heat shock protein 20 interacting with phosphorylated Akt reduces doxorubicin-triggered oxidative stress and cardiotoxicity.
Heat Shock Protein 22 Attenuates Doxorubicin-Induced Cardiotoxicity via Regulating Inflammation and Apoptosis.
Hsp90 inhibitor geldanamycin attenuates the cytotoxicity of sunitinib in cardiomyocytes via inhibition of the autophagy pathway.
Inhibition of CACNA1H attenuates doxorubicin-induced acute cardiotoxicity by affecting endoplasmic reticulum stress.
Overexpression of Hsp20 prevents endotoxin-induced myocardial dysfunction and apoptosis via inhibition of NF-kappaB activation.
Pretreatment effect of running exercise on HSP70 and DOX-induced cardiotoxicity.
Rosuvastatin and simvastatin attenuate cisplatin-induced cardiotoxicity via disruption of endoplasmic reticulum stress-mediated apoptotic death in rats: targeting ER-Chaperone GRP78 and Calpain-1 pathways.
Short-term exercise training protects against doxorubicin-induced cardiac mitochondrial damage independent of HSP72.
Synthesis of shock proteins in cultured fetal mouse myocardial cells.
The hERG channel is dependent upon the Hsp90? isoform for maturation and trafficking.
Cardiovascular Diseases
32nd national medicinal chemistry symposium - medicinal chemistry developments for neurodegeneration, diabetes and cancer.
Antibodies against heat shock protein 60 derived from Helicobacter pylori: diagnostic implications in cardiovascular disease.
Antibodies against human 60 kDa heat shock protein are not associated with cardiovascular disease in patients with rheumatoid arthritis.
Antibodies to heat-shock protein 65 and neopterin levels in patients with type 1 diabetes mellitus.
Association between plasma levels of heat shock protein 60 and cardiovascular disease in patients with diabetes mellitus.
Autoimmunity, Infectious Immunity, and Atherosclerosis.
Cardiovascular disease delay in centenarian offspring: role of heat shock proteins.
Characterization of heat shock protein 27 in extracellular vesicles: a potential anti-inflammatory therapy.
Chlamydia pneumoniae, heat shock proteins 60 and risk of secondary cardiovascular events in patients with coronary heart disease under special consideration of diabetes : a prospective study.
Circulating heat shock protein 60 is associated with early cardiovascular disease.
Comparative analysis of linear antibody epitopes on human and mycobacterial 60-kDa heat shock proteins using samples of healthy blood donors.
Correlation between heat-shock protein 27 serum concentration and common carotid intima-media thickness in hemodialysis patients.
Diesel exhaust inhalation induces heat shock protein 70 expression in vivo.
Effect of crocin on antibody titers to heat-shock protein 27 in subjects with metabolic syndrome.
Heat shock protein 27 immune complex altered signaling and transport (ICAST): Novel mechanisms of attenuating inflammation.
Heat Shock Protein 60 in Cardiovascular Physiology and Diseases.
Heat shock protein 70 accelerates atherosclerosis by downregulating the expression of ABCA1 and ABCG1 through the JNK/Elk-1 pathway.
Heat shock proteins in cardiovascular disease and the prognostic value of heat shock protein related measurements.
Heat shock proteins in obesity: links to cardiovascular disease.
Heat-shock protein 60 kDa and atherogenic dyslipidemia in patients with untreated mild periodontitis: a pilot study.
Induction of Dendritic Cell-Mediated Activation of T Cells From Atherosclerotic Plaques by Human Heat Shock Protein 60.
Molecular chaperones: Toward new therapeutic tools.
Multi-tissue analysis of co-expression networks by higher-order generalized singular value decomposition identifies functionally coherent transcriptional modules.
Neonatal Death and Heart Failure in Mouse with Transgenic HSP60 Expression.
Plasma concentration of heat shock protein 27 and risk of cardiovascular disease: a prospective, nested case-control study.
The left ventricle proteome differentiates middle-aged and old left ventricles in mice.
The potential role of heat shock protein 27 in cardiovascular disease.
The versatile stress protein mortalin as a chaperone therapeutic agent.
Unlike estrogens that increase PCSK9 levels post-menopause HSP27 vaccination lowers cholesterol levels and atherogenesis due to divergent effects on PCSK9 and LDLR.
Carotid Artery Diseases
Association between antibodies to heat shock protein 65 and coronary atherosclerosis. Possible mechanism of action of Helicobacter pylori and other bacterial infections in increasing cardiovascular risk.
Autoantibodies against heat shock protein 60 mediate endothelial cytotoxicity.
Cross-reactive B-cell epitopes of microbial and human heat shock protein 60/65 in atherosclerosis.
Heat shock proteins and autoimmunity in patients with carotid atherosclerosis.
Heat-shock protein 90: A novel autoantigen in human carotid atherosclerosis.
Oxidative Stress Induces HSP90 Upregulation on the Surface of Primary Human Endothelial Cells: Role of the Antioxidant 7,8-Dihydroxy-4-methylcoumarin in Preventing HSP90 Exposure to the Immune System.
Oxidized low-density lipoprotein autoantibodies, chronic infections, and carotid atherosclerosis in a population-based study.
The role of (auto-) immunity in atherogenesis.
Carotid Artery Injuries
Autoantibodies to heat shock protein 60 promote thrombus formation in a murine model of arterial thrombosis.
Carotid Stenosis
1267 HSP70-2 polymorphism as a risk factor for carotid plaque rupture and cerebral ischaemia in old type 2 diabetes-atherosclerotic patients.
A relationship between serological markers of chronic C. pneumoniae and CMV infection and hsp60 in patients with atherosclerotic carotid stenosis.
Increased expression of HDJ-2 (hsp40) in carotid artery atherosclerosis: a novel heat shock protein associated with luminal stenosis and plaque ulceration.
Involvement of -308 TNF-alpha and 1267 Hsp70-2 polymorphisms and zinc status in the susceptibility of coronary artery disease (CAD) in old patients.
Castleman Disease
Heat shock-enhanced T cell apoptosis with heat shock protein 70 on T cell surface in multicentric Castleman's disease.
Cat-Scratch Disease
Bartonella infections in fleas (Siphonaptera: Pulicidae) and lack of bartonellae in ticks (Acari: Ixodidae) from Hungary.
Evaluation of an internally controlled real-time polymerase chain reaction assay targeting the groEL gene for the detection of Bartonella spp. DNA in patients with suspected cat-scratch disease.
Rapid detection of Bartonella henselae heat shock protein DNA by nested polymerase chain reaction from swollen lymph nodes of a patient with cat-scratch disease.
Cataract
A possible relationship between cataract, increased levels of the major heat shock protein HSP 70 and decreased levels of S-antigen in the retina of the RCS rat.
Administration of antioxidant compounds affects the lens chaperone activity and prevents the onset of cataracts.
AlphaB-crystallin selectively targets intermediate filament proteins during thermal stress.
Aqueous humor heat-shock protein 70, periostin, and irisin levels in patients with pseudoexfoliation syndrome.
Association of partially folded lens betaB2-crystallins with the alpha-crystallin molecular chaperone.
Calcium-induced decrease of the thermal stability and chaperone activity of alpha-crystallin.
Chaperone-like activity and hydrophobicity of alpha-crystallin.
Decreased chaperone activity of alpha-crystallins in naphthalene-induced cataract possibly results from C-terminal truncation.
Differences in Unfolded Protein Response Pathway Activation in the Lenses of Three Types of Cataracts.
Effect of trifluoroethanol on ?-crystallin: folding, aggregation, amyloid, and cytotoxicity analysis.
Enhanced degradation and decreased stability of eye lens alpha-crystallin upon methylglyoxal modification.
Genetic polymorphisms of HSP70 in age-related cataract.
Glutathione reductase from human cataract lenses can be revived by reducing agents and by a molecular chaperone, alpha-crystallin.
H101G Mutation in Rat Lens ?B-Crystallin Alters Chaperone Activity and Divalent Metal Ion Binding.
Heat shock protein expression in human conjunctiva.
Heat shock proteins of adult and embryonic human ocular lenses.
Hydrophobic residues of melittin mediate its binding to ?A-crystallin.
Identification of Differential Gene Expression Pattern in Lens Epithelial Cells Derived from Cataractous and Noncataractous Lenses of Shumiya Cataract Rat.
Inactivation of glyceraldehyde 3-phosphate dehydrogenase by sugars, prednisolone-21-hemisuccinate, cyanate and other small molecules.
Interaction of Cu+2 with ?-Crystallin: A Biophysical and Mass Spectrometric Study.
Longitudinal Study of Age-Related Cataract Using Dynamic Light Scattering: Loss of ?-Crystallin Leads to Nuclear Cataract Development.
Loss of ?B-crystallin function in zebrafish reveals critical roles in the development of the lens and stress resistance of the heart.
Oxidation of cysteine residues from alpha-A crystallin during cataractogenesis of the human lens.
Structural and functional properties, chaperone activity and posttranslational modifications of alpha-crystallin and its related subunits in the crystalline lens: N-acetylcarnosine, carnosine and carcinine act as alpha- crystallin/small heat shock protein enhancers in prevention and dissolution of cataract in ocular drug delivery formulations of novel therapeutic agents.
Targeted disruption of the mouse alpha A-crystallin gene induces cataract and cytoplasmic inclusion bodies containing the small heat shock protein alpha B-crystallin.
The Human 343delT HSPB5 Chaperone Associated with Early-onset Skeletal Myopathy Causes Defects in Protein Solubility.
The impact of different water gas levels on cataract formation, muscle and lens free amino acids, and lens antioxidant enzymes and heat shock protein mRNA abundance in smolting Atlantic salmon, Salmo salar L.
The lens of the eye as a focusing device and its response to stress.
The Tudor-domain protein TDRD7, mutated in congenital cataract, controls the heat shock protein HSPB1 (HSP27) and lens fiber cell morphology.
Thioredoxin, thioredoxin reductase, and alpha-crystallin revive inactivated glyceraldehyde 3-phosphate dehydrogenase in human aged and cataract lens extracts.
Unfolded protein response activation in cataracts.
Unique contribution of heat shock transcription factor 4 in ocular lens development and fiber cell differentiation.
UPR Activation and the Down-Regulation of ?-Crystallin in Human High Myopia-Related Cataract Lens Epithelium.
Zn2+ enhances the molecular chaperone function and stability of alpha-crystallin.
[Character of alpha-crystallin molecular chaperone activity in selenite cataract]
[The molecular chaperone function of alpha-crystallin in age-related cataract]
[The recent progress on the role of alpha-crystallin as a molecular chaperone in cataractogenesis]
Celiac Disease
AlphaB-crystallin expression in celiac disease - a preliminary study.
Evidence for a role of autoantibodies to heat shock protein 60, 70, and 90 in patients with dermatitis herpetiformis.
HLA-linked heat-shock protein 70 (HSP70-2) gene polymorphism and celiac disease.
Increased heat shock protein 72 expression in celiac disease.
Central Nervous System Diseases
17-AAG post-treatment ameliorates memory impairment and hippocampal CA1 neuronal autophagic death induced by transient global cerebral ischemia.
Cloning, characterization, and functional studies of a human 40-kDa catecholamine-regulated protein: implications in central nervous system disorders.
Small heat shock proteins, the cytoskeleton, and inclusion body formation.
Central Nervous System Infections
[Significance of heat shock protein 70 in cerebrospinal fluid in differential diagnosis of central nervous system infection in children]
Cerebellar Diseases
GRP78 antibodies damage the blood-brain barrier and relate to cerebellar degeneration in Lambert-Eaton myasthenic syndrome.
Cerebral Amyloid Angiopathy
Heat shock proteins and amateur chaperones in amyloid-Beta accumulation and clearance in Alzheimer's disease.
Cerebral Hemorrhage
Deferoxamine affects heat shock protein expression in heart after intracerebral hemorrhage in aged rats.
Effects of minocycline on the expression of NGF and HSP70 and its neuroprotection role following intracerebral hemorrhage in rats.
Heat shock protein 70 upregulation by geldanamycin reduces brain injury in a mouse model of intracerebral hemorrhage.
Heme oxygenase-1 and heat shock protein 70 induction in glia and neurons throughout rat brain after experimental intracerebral hemorrhage.
Increased Expression of Small Heat Shock Protein ?B-crystallin After Intracerebral Hemorrhage in Adult Rats.
Inducible heat shock protein 70, interleukin-18, and tumor necrosis factor alpha correlate with outcomes in spontaneous intracerebral hemorrhage.
Overexpression of GRP75 inhibits inflammation in a rat model of intracerebral hemorrhage.
Pharmacological induction of heat shock protein exerts neuroprotective effects in experimental intracerebral hemorrhage.
Cerebral Infarction
Correlation of lymphocyte heat shock protein 70 levels with neurologic deficits in elderly patients with cerebral infarction.
Geranylgeranylacetone, a noninvasive heat shock protein inducer, induces protein kinase C and leads to neuroprotection against cerebral infarction in rats.
Heat shock protein 70 expression in the brain of rats with cerebral infarction after receiving vascular endothelial growth factor 165 gene therapy.
Mice overexpressing rat heat shock protein 70 are protected against cerebral infarction.
Neuroprotective effect of geranylgeranylacetone, a noninvasive heat shock protein inducer, on cerebral infarction in rats.
Protective effects of Progranulin against focal cerebral ischemia-reperfusion injury in rats by suppressing endoplasmic reticulum stress and NF-?B activation in reactive astrocytes.
Protein Nanoparticles Modified with PDGF-B as a Novel Therapy After Acute Cerebral Infarction.
S100ß, Matrix Metalloproteinase-9, D-dimer, and Heat Shock Protein 70 Are Serologic Biomarkers of Acute Cerebral Infarction in a Mouse Model of Transient MCA Occlusion.
Semi-quantitative analyses of hippocampal heat shock protein-70 expression based on the duration of ischemia and the volume of cerebral infarction in mice.
The novel GLP-1/GIP dual agonist DA3-CH is more effective than liraglutide in reducing endoplasmic reticulum stress in diabetic rats with cerebral ischemia-reperfusion injury.
[Effects of Electroacupuncture and Intracerebral Injection of VEGF on Caspase12, Caspase3, and GRP78 Genes in Rats with Cerebral Ischemia-Reperfusion Injury].
[G protein-coupled estrogen receptor alleviates cerebral ischemia-reperfusion injury through inhibiting endoplasmic reticulum stress].
[Gene therapy for cerebral infarction (cerebral ischemia)]
[Study on plasma antibodies against heat shock protein 70 in the hypertensive patients with cerebral infarction]
Cerebrovascular Disorders
Heat Shock Protein 70 kDa as a Target for Diagnostics and Therapy of Cardiovascular and Cerebrovascular Diseases.
Cervical Intraepithelial Neoplasia
A phase II study of Hsp-7 (SGN-00101) in women with high-grade cervical intraepithelial neoplasia.
Heat shock protein 27 and p16 immunohistochemistry in cervical intraepithelial neoplasia and squamous cell carcinoma.
Immunohistochemical evaluation of heat shock proteins in normal and preinvasive lesions of the cervix.
Overexpression of heat shock protein 27 in squamous cell carcinoma of the uterine cervix: a proteomic analysis using archival formalin-fixed, paraffin-embedded tissues.
Use of protein-based biomarkers of exfoliated cervical cells for primary screening of cervical cancer.
Chagas Disease
Gene expression and molecular modeling of the HSP104 chaperone of Trypanosoma cruzi.
Identification of HLA-A?02:01-restricted CTL epitopes in Trypanosoma cruzi heat shock protein-70 recognized by Chagas disease patients.
Multilocus PCR-RFLP profiling in Trypanosoma cruzi I highlights an intraspecific genetic variation pattern.
Recombinant Leishmania Hsp90 and Hsp70 are recognized by sera from visceral leishmaniasis patients but not Chagas' disease patients.
Trypanosoma cruzi: modulation of HSP70 mRNA stability by untranslated regions during heat shock.
Chancroid
Laboratory diagnosis of chancroid using species-specific primers from Haemophilus ducreyi groEL and the polymerase chain reaction.
The dnaK/dnaJ operon of Haemophilus ducreyi contains a unique combination of regulatory elements.
Charcot-Marie-Tooth Disease
A knock-in/knock-out mouse model of HSPB8-associated distal hereditary motor neuropathy and myopathy reveals toxic gain-of-function of mutant Hspb8.
A novel Lys141Thr mutation in small heat shock protein 22 (HSPB8) gene in Charcot-Marie-Tooth disease type 2L.
A novel p.Glu175X premature stop mutation in the C-terminal end of HSP27 is a cause of CMT2.
A novel p.T139M mutation in HSPB1 highlighting the phenotypic spectrum in a family.
A novel transgenic mouse model of Chinese Charcot-Marie-Tooth disease type 2L.
Abnormal small heat shock protein interactions involving neuropathy-associated HSP22 (HSPB8) mutants.
Characterization of human small heat shock protein HSPB1 ?-crystallin domain localized mutants associated with hereditary motor neuron diseases.
Distal hereditary motor neuropathy in Korean patients with a small heat shock protein 27 mutation.
Heat shock protein 27 R127W mutation: evidence of a continuum between axonal Charcot-Marie-Tooth and distal hereditary motor neuropathy.
Increased monomerization of mutant HSPB1 leads to protein hyperactivity in Charcot-Marie-Tooth neuropathy.
Mitochondrial deficits and abnormal mitochondrial retrograde axonal transport play a role in the pathogenesis of mutant Hsp27-induced Charcot Marie Tooth Disease.
Mutant HSPB8 causes protein aggregates and a reduced mitochondrial membrane potential in dermal fibroblasts from distal hereditary motor neuropathy patients.
Mutation analysis of the small heat shock protein 27 gene in chinese patients with Charcot-Marie-Tooth disease.
Small heat shock protein B3 (HSPB3) mutation in an axonal Charcot-Marie-Tooth disease family.
The small heat shock protein HspB8: role in nervous system physiology and pathology.
[Mutation analysis of small heat shock protein 27 gene in Chinese patients with Charcot-Marie-Tooth disease]
[Study on aggregate formation mechanism of HSPB8 gene mutation resulting in CMT2L]
Chemical and Drug Induced Liver Injury
Analysis of IL-6, STAT3 and HSPA1L gene polymorphisms in anti-tuberculosis drug-induced hepatitis in a nested case-control study.
Biocharacterization of Heat Shock Protein 90 in Acetaminophen-Treated Livers Without Conspicuous Drug Induced Liver Injury.
Macrophage migration inhibitory factor in drug-induced liver injury: a role in susceptibility and stress responsiveness.
[Study on polymorphisms of genes with susceptibility to drug induced liver injury in a cohort receiving anti-tuberculosis treatment].
Chickenpox
Molecular mimicry between varicella, measles virus and Hsp60 in type 1 diabetes associated HLA-DR3/DR4 molecules.
Chlamydophila Infections
Chlamydia pneumoniae infection acts as an endothelial stressor with the potential to initiate the earliest heat shock protein 60-dependent inflammatory stage of atherosclerosis.
Induction of oral tolerance as treatment or prevention of chronic diseases associated with Chlamydia pneumoniae infection--hypothesis.
Serum immunoglobulin G antibodies to chlamydial heat shock protein 60 but not to human and bacterial homologs are associated with coronary artery disease.
Cholangiocarcinoma
Antitumor activity of the combination of an HSP90 inhibitor and a PI3K/mTOR dual inhibitor against cholangiocarcinoma.
Characterization and prognostic significance of mortalin, Bcl-2 and Bax in intrahepatic cholangiocarcinoma.
Combined treatment of cholangiocarcinoma with interventional radiofrequency hyperthermia and heat shock protein promoter-mediated HSV-TK gene therapy.
Gene expression-based chemical genomics identifies heat-shock protein 90 inhibitors as potential therapeutic drugs in cholangiocarcinoma.
Glutamine Synthetase, Heat shock Protein-70, and Glypican-3 in Intrahepatic Cholangiocarcinoma and Tumors Metastatic to Liver.
Heat Shock Protein 90 Is a Potential Therapeutic Target in Cholangiocarcinoma.
Heat shock proteins 27 and 70 are potential biliary markers for the detection of cholangiocarcinoma.
Helicobacter pylori GroEL Seropositivity Is Associated with an Increased Risk of Opisthorchis viverrini-Associated Hepatobiliary Abnormalities and Cholangiocarcinoma.
HSP90 inhibition drives degradation of FGFR2 fusion proteins: implications for treatment of cholangiocarcinoma.
JNK contributes to the tumorigenic potential of human cholangiocarcinoma cells through the mTOR pathway regulated GRP78 induction.
MIR21 Drives Resistance to Heat Shock Protein 90 Inhibition in Cholangiocarcinoma.
Mortalin promotes cell proliferation and epithelial mesenchymal transition of intrahepatic cholangiocarcinoma cells in vitro.
Phosphoproteome Profiling of Isogenic Cancer Cell-Derived Exosome Reveals HSP90 as a Potential Marker for Human Cholangiocarcinoma.
Plasma autoantibodies against heat shock protein 70, enolase 1 and ribonuclease/angiogenin inhibitor 1 as potential biomarkers for cholangiocarcinoma.
TGR5 promotes cholangiocarcinoma by interacting with mortalin.
The heat shock protein 90 inhibitor 17-AAG suppresses growth and induces apoptosis in human cholangiocarcinoma cells.
Cholangitis, Sclerosing
Immuno-gold electron microscopical detection of heat shock protein 60 (hsp60) in mitochondria of rat hepatocytes and myocardiocytes.
Cholera
A novel design of a multi-antigenic, multistage and multi-epitope vaccine against Helicobacter pylori: An in silico approach.
Co- and post-translocation roles for HSP90 in cholera Intoxication.
Determination of the conformations of bound peptides using NMR-transferred nOe techniques.
GRP75 upregulates clathrin-independent endocytosis through actin cytoskeleton reorganization mediated by the concurrent activation of Cdc42 and RhoA.
Host Cell Chaperones Hsp70/Hsp90 and Peptidyl-Prolyl Cis/Trans Isomerases Are Required for the Membrane Translocation of Bacterial ADP-Ribosylating Toxins.
HSC70 and HSP90 chaperones perform complementary roles in translocation of the cholera toxin A1 subunit from the endoplasmic reticulum to the cytosol.
Hsp90 is required for transfer of the cholera toxin A1 subunit from the endoplasmic reticulum to the cytosol.
In vivo induced clpB1 gene of Vibrio cholerae is involved in different stress responses and affects in vivo cholera toxin production.
Magnetic nanoparticle-based isolation of endocytic vesicles reveals a role of the heat shock protein GRP75 in macromolecular delivery.
Cholestasis
Alpha-crystallin is a target gene of the farnesoid X-activated receptor in human livers.
Cholesteatoma
Heat shock proteins in middle ear cholesteatoma.
TFIIB-related factor 2 regulates glucose-regulated protein 78 expression in acquired middle ear cholesteatoma.
Upregulation of phosphorylated HSP27, PRDX2, GRP75, GRP78 and GRP94 in acquired middle ear cholesteatoma growth.
Cholesteatoma, Middle Ear
TFIIB-related factor 2 regulates glucose-regulated protein 78 expression in acquired middle ear cholesteatoma.
Upregulation of phosphorylated HSP27, PRDX2, GRP75, GRP78 and GRP94 in acquired middle ear cholesteatoma growth.
Chondroma
Heat shock protein 72 expression in chondrosarcoma correlates with differentiation.
Chondrosarcoma
Differential expression of angiogenesis markers HSP70, HSP90, VEGF and pERK1/2 in both components of dedifferentiated chondrosarcomas.
Distinct profiles of oxidative stress-related and matrix proteins in adult bone and soft tissue osteosarcoma and desmoid tumors: A proteomics study.
Heat shock protein 72 expression in chondrosarcoma correlates with differentiation.
HSPA8 as a novel fusion partner of NR4A3 in extraskeletal myxoid chondrosarcoma.
In Vitro and In Vivo Studies of the Biological Effects of Bioceramic (a Material of Emitting High Performance Far-Infrared Ray) Irradiation.
Recurrence rate and progression of chondrosarcoma is correlated with heat shock protein expression.
Chorioamnionitis
Amniotic fluid heat shock protein 70 concentration in histologic chorioamnionitis, term and preterm parturition.
Decreased expression of angiogenic factors in placentas with chorioamnionitis after preterm birth.
Choriocarcinoma
The heat shock protein 60 promotes progesterone synthesis in mitochondria of JEG-3 cells.
Chromoblastomycosis
Expression of heat shock protein 27 in chromomycosis.
Chronic Periodontitis
Association between circulating levels of heat-shock protein 27 and aggressive periodontitis.
Evaluation of Salivary Level of Heat Shock Protein 70 in Patients with Chronic Periodontitis.
Monitoring of dnaK gene expression in Porphyromonas gingivalis by oxygen stress using DNA microarray.
Pep19 drives epitope spreading in periodontitis and periodontitis-associated autoimmune diseases.
Chronic Urticaria
Elevated circulating heat shock protein 70 and its antibody concentrations in chronic spontaneous urticaria.
Ciliary Motility Disorders
Mutations in DNAJB13, Encoding an HSP40 Family Member, Cause Primary Ciliary Dyskinesia and Male Infertility.
Classical Swine Fever
Molecular chaperone Jiv promotes the RNA replication of classical swine fever virus.
Cleft Palate
Gene expression of Hsp70, Hsp90 and Hsp110 families in normal palate and cleft palate during mouse embryogenesis.
P1 and cosmid clones define the organization of 280 kb of the mouse H-2 complex containing the Cps-1 and Hsp70 loci.
[Expression of sHsps of normal palate and cleft palate during mouse embryogenesis]
Clubfoot
EVEN-PLUS syndrome: A case report with novel variants in HSPA9 and evidence of HSPA9 gene dysfunction.
Coccidiosis
Eimeria tenella heat shock protein 70 enhances protection of recombinant microneme protein MIC2 subunit antigen vaccination against E. tenella challenge.
Heat shock protein 90 genes of two species of poultry Eimeria: expression and evolutionary analysis.
The heat shock protein 90 of Eimeria tenella is essential for invasion of host cell and schizont growth.
Coinfection
Anaplasma platys-like strains in ruminants from Tunisia.
Diversity of Anaplasma species and importance of mixed infections in roe deer from Spain.
Expression and purification of active receptor interacting protein 1 kinase using a baculovirus system.
First Report of Cucurbit Chlorotic Yellows Virus affecting Watermelon in USA.
Improvement of the production of GFPuv-beta1,3-N-acetylglucosaminyltransferase 2 fusion protein using a molecular chaperone-assisted insect-cell-based expression system.
Localization of sweet potato chlorotic stunt virus (SPCSV) in synergic infection with potyviruses in sweet potato.
Molecular Detection of Bartonella spp. and Hematological Evaluation in Domestic Cats and Dogs from Bangkok, Thailand.
Multiple Chlamydiaceae species in trachoma: implications for disease pathogenesis and control.
Serum levels of HSP70 and other DAMP proteins can aid in patient diagnosis after traumatic injury.
Subterranean Mammals: Reservoirs of Infection or Overlooked Sentinels of Anthropogenic Environmental Soiling?
Colic
Plasma levels of heat shock protein 72 (HSP72) and beta-endorphin as indicators of stress, pain and prognosis in horses with colic.
Colitis
A Humanized Monoclonal Antibody against Heat Shock Protein 60 Suppresses Murine Arthritis and Colitis and Skews the Cytokine Balance toward an Anti-Inflammatory Response.
Absence of ABCG2-mediated mucosal detoxification in patients with active inflammatory bowel disease is due to impeded protein folding.
Activation of sirtuin 1 by catalpol-induced down-regulation of microRNA-132 attenuates endoplasmic reticulum stress in colitis.
Amelioration of dextran sulfate colitis by butyrate: role of heat shock protein 70 and NF-kappaB.
Daikenchuto, a kampo medicine, regulates intestinal fibrosis associated with decreasing expression of heat shock protein 47 and collagen content in a rat colitis model.
Effect of preinduction of heat shock proteins on acetic acid-induced colitis in rats.
Elongated Flexuous Plant Virus-Derived Nanoparticles Functionalized for Autoantibody Detection.
Evaluation of ubiquitinated proteins by proteomics reveals the role of the ubiquitin proteasome system in the regulation of Grp75 and Grp78 chaperone proteins during intestinal inflammation.
Exogenous heat shock protein gp96 ameliorates CD4+CD62L+ T-cell-mediated transfer colitis.
Genetic evidence for a protective role for heat shock factor 1 and heat shock protein 70 against colitis.
Hyperthermia ameliorates 2,4,6-trinitrobenzene sulphonic acid-induced colitis in rats: the role of heat shock proteins.
Induction of dsRNA-activated protein kinase links mitochondrial unfolded protein response to the pathogenesis of intestinal inflammation.
Inflammation-induced, 3'UTR-dependent translational inhibition of Hsp70 mRNA impairs intestinal homeostasis.
Inhibition of N-terminal ATPase on HSP90 attenuates colitis through enhanced Treg function.
Lactobacillus stress protein GroEL prevents colonic inflammation.
Low and medium but not high doses of green tea polyphenols ameliorated dextran sodium sulfate-induced hepatotoxicity and nephrotoxicity.
Mouse colitis induced by Escherichia coli producing Yersinia enterocolitica 60-kilodalton heat-shock protein: light and electron microscope study.
Mucosal expression by B7-positive cells of the 60-kilodalton heat-shock protein in inflammatory bowel disease.
Oral targeted delivery by nanoparticles enhances efficacy of an Hsp90 inhibitor by reducing systemic exposure in murine models of colitis and colitis-associated cancer.
Resistance to experimental colitis depends on cytoprotective heat shock proteins in macrophage migration inhibitory factor null mice.
RNF186 regulates EFNB1 (ephrin B1)-EPHB2-induced autophagy in the colonic epithelial cells for the maintenance of intestinal homeostasis.
Role of heat shock protein 47 in intestinal fibrosis of experimental colitis.
Sex- and Corticotropin-releasing Factor Receptor 2- dependent Actions of Urocortin 1 during inflammation.
Colitis, Ischemic
Absence of ABCG2-mediated mucosal detoxification in patients with active inflammatory bowel disease is due to impeded protein folding.
Colitis, Ulcerative
Autoimmunity to heat shock protein 40 in ulcerative colitis.
Changes in Immunohistochemical Levels and Subcellular Localization After Therapy and Correlation and Colocalization With CD68 Suggest a Pathogenetic Role of Hsp60 in Ulcerative Colitis.
Correlation between depression, anxiety, and polymorphonuclear cells' resilience in ulcerative colitis: the mediating role of heat shock protein 70.
Geranylgeranylacetone suppresses colitis?related mouse colon carcinogenesis.
Gp96 Peptide Antagonist gp96-II Confers Therapeutic Effects in Murine Intestinal Inflammation.
Heat shock protein gene 70-2 polymorphism is differentially associated with the clinical phenotypes of ulcerative colitis and Crohn's disease.
Heat-shock protein 70-2 BB genotype is associated with reduced risks of the steroid-dependent and refractory phenotypes of ulcerative colitis.
How autophagy controls the intestinal epithelial barrier.
Hsp10, Hsp70, and Hsp90 immunohistochemical levels change in ulcerative colitis after therapy.
Hsp60 and Hsp10 increase in colon mucosa of Crohn's disease and ulcerative colitis.
Impaired humoral immune response against mycobacterial 65-kDa heat shock protein (HSP65) in patients with inflammatory bowel disease.
Increased Levels of Survivin, via Association With Heat Shock Protein 90, in Mucosal T Cells From Patients With Crohn's Disease.
Inflammatory Bowel Disease-Associated Interleukin-33 Is Preferentially Expressed in Ulceration-Associated Myofibroblasts.
Intestinal expression of human heat shock protein 90 in patients with Crohn's disease and ulcerative colitis.
Mucosal expression by B7-positive cells of the 60-kilodalton heat-shock protein in inflammatory bowel disease.
Oral targeted delivery by nanoparticles enhances efficacy of an Hsp90 inhibitor by reducing systemic exposure in murine models of colitis and colitis-associated cancer.
RNF186 regulates EFNB1 (ephrin B1)-EPHB2-induced autophagy in the colonic epithelial cells for the maintenance of intestinal homeostasis.
Up-regulation of mitochondrial chaperone TRAP1 in ulcerative colitis associated colorectal cancer.
Colitis-Associated Neoplasms
Molecular regulation of macrophages in unleashing cancer-related inflammation.
Oral targeted delivery by nanoparticles enhances efficacy of an Hsp90 inhibitor by reducing systemic exposure in murine models of colitis and colitis-associated cancer.
Up-regulation of mitochondrial chaperone TRAP1 in ulcerative colitis associated colorectal cancer.
Colonic Neoplasms
17-Allylamino-17-demethoxygeldanamycin overcomes TRAIL resistance in colon cancer cell lines.
90-kDa heat shock protein inhibition abrogates the topoisomerase I poison-induced G2/M checkpoint in p53-null tumor cells by depleting Chk1 and Wee1.
A novel, small molecule inhibitor of Hsc70/Hsp70 potentiates Hsp90 inhibitor induced apoptosis in HCT116 colon carcinoma cells.
Acetylation modification regulates GRP78 secretion in colon cancer cells.
Acquired resistance to 5-fluorouracil via HSP90/Src-mediated increase in thymidylate synthase expression in colon cancer.
Activating transcription factor-3 (ATF3) functions as a tumor suppressor in colon cancer and is up-regulated upon heat-shock protein 90 (Hsp90) inhibition.
Ajuba receptor mediates the internalization of tumor-secreted GRP78 into macrophages through different endocytosis pathways.
Antiproliferative effect of p-Coumaric acid targets UPR activation by downregulating Grp78 in colon cancer.
Antitumor effect of pretreatment for colon cancer cells with hyperthermia plus geranylgeranylacetone in experimental metastasis models and a subcutaneous tumor model of colon cancer in mice.
BAG3-dependent expression of Mcl-1 confers resistance of mutant KRAS colon cancer cells to the HSP90 inhibitor AUY922.
Blocking heat shock protein-90 inhibits the invasive properties and hepatic growth of human colon cancer cells and improves the efficacy of oxaliplatin in p53-deficient colon cancer tumors in vivo.
Both Bupivacaine and Levobupivacaine inhibit colon cancer cell growth but not melanoma cells in vitro.
Calnexin, an ER-induced protein, is a prognostic marker and potential therapeutic target in colorectal cancer.
Cell-bound exopolysaccharide from probiotic bacteria induces autophagic cell death of tumour cells.
Co-crystalization and in vitro biological characterization of 5-aryl-4-(5-substituted-2-4-dihydroxyphenyl)-1,2,3-thiadiazole hsp90 inhibitors.
Colon cancer cell treatment with rose bengal generates a protective immune response via immunogenic cell death.
Colon cancer cells expressing cell surface GRP78 as a marker for reduced tumorigenicity.
Cryptotanshinone-Induced p53-Dependent Sensitization of Colon Cancer Cells to Apoptotic Drive by Regulation of Calpain and Calcium Homeostasis.
Curcumin Reverses 5-Fluorouracil Resistance by Promoting Human Colon Cancer HCT-8/5-FU Cell Apoptosis and Down-regulating Heat Shock Protein 27 and P-Glycoprotein.
DCZ5248, a novel dual inhibitor of Hsp90 and autophagy, exerts antitumor activity against colon cancer.
Delivery of functional exogenous proteins by plant-derived vesicles to human cells in vitro.
DHA induces apoptosis by altering the expression and cellular location of GRP78 in colon cancer cell lines.
Downregulation of DNAJC10 (ERDJ5) is associated with poor survival in breast cancer.
Effect of Root Extracts of Medicinal Herb Glycyrrhiza glabra on HSP90 Gene Expression and Apoptosis in the HT-29 Colon Cancer Cell Line.
Enhanced Susceptibility to 5-Fluorouracil in Human Colon Cancer Cells by Silencing of GRP78.
Epigenetic effects of inhibition of heat shock protein 90 (HSP90) in human pancreatic and colon cancer.
Expression analysis of heat shock protein 90 (HSP90) and Her2 in colon carcinoma.
Expression of stress response protein glucose regulated protein-78 mediated by c-Myb.
Expression profile of significant immortalization genes in colon cancer.
Extracellular Hsp90 and TGF? regulate adhesion, migration and anchorage independent growth in a paired colon cancer cell line model.
Ganetespib, a novel Hsp90 inhibitor in patients with KRAS mutated and wild type, refractory metastatic colorectal cancer.
Geldanamycin promotes premature mitotic entry and micronucleation in irradiated p53/p21 deficient colon carcinoma cells.
Geldanamycin-Induced PCNA Degradation in Isolated Hsp90 Complex from Cancer Cells.
Gene expression profiling of human colon cancer cells following inhibition of signal transduction by 17-allylamino-17-demethoxygeldanamycin, an inhibitor of the hsp90 molecular chaperone.
Glucose regulated protein 78 promotes cell invasion via regulation of uPA production and secretion in colon cancer cells.
Glucose-regulated protein 78 (GRP78) regulates colon cancer metastasis through EMT biomarkers and the NRF-2/HO-1 pathway.
Glucose-regulated protein 78 mediates the therapeutic efficacy of 17-DMAG in colon cancer cells.
Glucose-regulated protein 78 silencing down-regulates vascular endothelial growth factor/vascular endothelial growth factor receptor 2 pathway to suppress human colon cancer tumor growth.
GRP-induced up-regulation of Hsp72 promotes CD16+/94+ natural killer cell binding to colon cancer cells causing tumor cell cytolysis.
GRP78 knockdown enhances apoptosis via the down-regulation of oxidative stress and Akt pathway after epirubicin treatment in colon cancer DLD-1 cells.
GRP78 mediates the therapeutic efficacy of curcumin on colon cancer.
GRP78 Regulates Apoptosis, Cell Survival and Proliferation in 5-Fluorouracil-resistant SNUC5 Colon Cancer Cells.
GRP78 secreted by colon cancer cells facilitates cell proliferation via PI3K/Akt signaling.
Heat shock cognate protein 70 encodes antigenic epitopes recognised by HLA-B4601-restricted cytotoxic T lymphocytes from cancer patients.
Heat shock protein 27 influences the anti-cancer effect of curcumin in colon cancer cells through ROS production and autophagy activation.
Heat shock protein 27 knockdown using nucleotide?based therapies enhances sensitivity to 5-FU chemotherapy in SW480 human colon cancer cells.
Heat shock protein 27, a novel regulator of 5-fluorouracil resistance in colon cancer.
Heat shock protein 70 neutralization exerts potent antitumor effects in animal models of colon cancer and melanoma.
Heat Shock Protein 70s as Potential Molecular Targets for Colon Cancer Therapeutics.
High HSP27 and HSP70 expression levels are independent adverse prognostic factors in primary resected colon cancer.
Histone deacetylase inhibitor valproic acid inhibits cancer cell proliferation via down-regulation of the alzheimer amyloid precursor protein.
Hsp90 inhibitor sensitizes TRAIL-mediated apoptosis via chop-dependent DR5 upregulation in colon cancer cells.
Hsp90 inhibitors promote p53-dependent apoptosis through PUMA and Bax.
Hsp90 inhibitors sensitise human colon cancer cells to topoisomerase I poisons by depletion of key anti-apoptotic and cell cycle checkpoint proteins.
HSP90 Inhibitors, Geldanamycin and Radicicol, Enhance Fisetin-Induced Cytotoxicity via Induction of Apoptosis in Human Colonic Cancer Cells.
Hsp90-binding immunophilins link p53 to dynein during p53 transport to the nucleus.
Human colon cancer cells differ in their sensitivity to curcumin-induced apoptosis and heat shock protects them by inhibiting the release of apoptosis-inducing factor and caspases.
Hybrid Nanoparticles Modified by Hyaluronic Acid Loading an HSP90 Inhibitor as a Novel Delivery System for Subcutaneous and Orthotopic Colon Cancer Therapy.
Identification of a ternary protein-complex as a therapeutic target for K-Ras-dependent colon cancer.
Identification of Tumor Antigen AF20 as Glycosylated Transferrin Receptor 1 in Complex with Heat Shock Protein 90 and/or Transporting ATPase.
Increased expression of co-chaperone HOP with HSP90 and HSC70 and complex formation in human colonic carcinoma.
Increased sensitivity of human colon cancer cells to DNA cross-linking agents after GRP78 up-regulation.
Indirect participation of Hsp90 in the regulation of the cyclin E turnover.
Inducible heat shock protein 70 prevents multifocal flat dysplastic lesions and invasive tumors in an inflammatory model of colon cancer.
Induction of HSF1 expression is associated with sporadic colorectal cancer.
Induction of Hsp60 by Photofrin-mediated photodynamic therapy.
Inhibition of Heat Shock Protein 90 as a Novel Platform for the Treatment of Cancer.
Inhibition of HSP90 by AUY922 Preferentially Kills Mutant KRAS Colon Cancer Cells by Activating Bim through ER Stress.
Inhibition of Hsp90 with synthetic macrolactones: synthesis and structural and biological evaluation of ring and conformational analogs of radicicol.
Low molecular weight heat shock protein HSP27 is a prognostic indicator in rectal cancer but not colon cancer.
Magnetic resonance spectroscopic pharmacodynamic markers of the heat shock protein 90 inhibitor 17-allylamino,17-demethoxygeldanamycin (17AAG) in human colon cancer models.
Mortalin/HSPA9 targeting selectively induces KRAS tumor cell death by perturbing mitochondrial membrane permeability.
N-myristoyltransferase inhibitor protein is homologous to heat shock cognate protein 70.
Novel immunohistochemical monoclonal antibody against human glucose-regulated protein 78.
Overexpressed GRP78 affects EMT and cell-matrix adhesion via autocrine TGF-?/Smad2/3 signaling.
Overexpression of glucose-regulated protein 78 in colon cancer.
Oxidative stress plays a critical role in inactivating mutant BRAF by geldanamycin derivatives.
p53 Regulates Hsp90 ATPase Activity and Thereby Wnt Signaling by Modulating Aha1 Expression.
PADI3 plays an antitumor role via the Hsp90/CKS1 pathway in colon cancer.
Pharmacological Inhibition of HSP90 Radiosensitizes Head and Neck Squamous Cell Carcinoma Xenograft by Inhibition of DNA Damage Repair, Nucleotide Metabolism, and Radiation-Induced Tumor Vasculogenesis.
Phloroglucinol derivative MCPP induces cell apoptosis in human colon cancer.
Polymer mediated transport of the Hsp90 inhibitor LB76, a polar cyclic peptide, produces an Hsp90 cellular phenotype.
Prediagnostic Helicobacter pylori Antibodies and Colorectal Cancer Risk in an Elderly, Caucasian Population.
Proteasome inhibition potentiates the cytotoxic effects of hyperthermia in HT-29 colon cancer cells through inhibition of heat shock protein 27.
Proteomics-based identification of a tumor-associated antigen and its corresponding autoantibody in gastric cancer.
Quantitative effects on c-Jun N-terminal protein kinase signaling determine synergistic interaction of cisplatin and 17-allylamino-17-demethoxygeldanamycin in colon cancer cell lines.
Reactivation of ERK and Akt confers resistance of mutant BRAF colon cancer cells to the HSP90 inhibitor AUY922.
Rebalancing Protein Homeostasis Enhances Tumor Antigen Presentation.
Role of apoptosis in colon cancer biology, therapy, and prevention.
Secreted heat shock protein 90alpha induces colorectal cancer cell invasion through CD91/LRP-1 and NF-kappaB-mediated integrin alphaV expression.
ShRNA-mediated gene silencing of Heat shock protein 70 inhibits human colon cancer cell growth in vitro and in vivo.
ShRNA-mediated gene silencing of heat shock protein 70 inhibits human colon cancer growth.
Silencing the cochaperone CDC37 destabilizes kinase clients and sensitizes cancer cells to HSP90 inhibitors.
Suppression of heat shock protein 27 expression promotes 5-fluorouracil sensitivity in colon cancer cells in a xenograft model.
Sustained activation of protein kinase C downregulates nuclear factor-kappaB signaling by dissociation of IKK-gamma and Hsp90 complex in human colonic epithelial cells.
Targeting the Hsp90 molecular chaperone with novel macrolactams. Synthesis, structural, binding, and cellular studies.
The interplay between GRP78 expression and Akt activation in human colon cancer cells under celecoxib treatment.
The molecular chaperone Cosmc enhances malignant behaviors of colon cancer cells via activation of Akt and ERK.
Tosylcyclonovobiocic acids promote cleavage of the hsp90-associated cochaperone p23.
Upregulated Heat Shock Proteins After Hyperthermic Chemotherapy Point to Induced Cell Survival Mechanisms in Affected Tumor Cells From Peritoneal Carcinomatosis.
Colorectal Neoplasms
(-)-Epigallocatechin Gallate (EGCG) Enhances the Sensitivity of Colorectal Cancer Cells to 5-FU by Inhibiting GRP78/NF-?B/miR-155-5p/MDR1 Pathway.
A novel HSP90 inhibitor with reduced hepatotoxicity synergizes with radiotherapy to induce apoptosis, abrogate clonogenic survival, and improve tumor control in models of colorectal cancer.
Anti-cancer effects of chemotherapeutic agent; 17-AAG, in combined with gold nanoparticles and irradiation in human colorectal cancer cells.
Antiangiogenic effects of ganetespib in colorectal cancer mediated through inhibition of HIF-1? and STAT-3.
ASK1-JNK signaling cascade mediates Ad-ST13-induced apoptosis in colorectal HCT116 cells.
ATAD3A stabilizes GRP78 to suppress ER stress for acquired chemoresistance in colorectal cancer.
Berberine inhibits proliferation and migration of colorectal cancer cells by downregulation of GRP78.
Blocking heat shock protein-90 inhibits the invasive properties and hepatic growth of human colon cancer cells and improves the efficacy of oxaliplatin in p53-deficient colon cancer tumors in vivo.
Cell-surface GRP78 facilitates colorectal cancer cell migration and invasion.
Cetuximab promotes SN38 sensitivity via suppression of heat shock protein 27 in colorectal cancer cells with wild-type RAS.
CFTR interacts with Hsp90 and regulates the phosphorylation of AKT and ERK1/2 in colorectal cancer cells.
Circulating mitochondrial stress 70 protein/mortalin and cytosolic Hsp70 in blood: Risk indicators in colorectal cancer.
Clinicopathologic significance of TRAP1 expression in colorectal cancer: a large scale study of human colorectal adenocarcinoma tissues.
Colon cancer cells expressing cell surface GRP78 as a marker for reduced tumorigenicity.
Combination of TRAP1 and ERCC1 Expression Predicts Clinical Outcomes in Metastatic Colorectal Cancer Treated with Oxaliplatin/5-Fluorouracil.
Combination therapies with HSP90 inhibitors against colorectal cancer.
Combining Trail with PI3 Kinase or HSP90 inhibitors enhances apoptosis in colorectal cancer cells via suppression of survival signaling.
Comparative Study of 17-AAG and NVP-AUY922 in Pancreatic and Colorectal Cancer Cells: Are There Common Determinants of Sensitivity?
Decreased expression of heat shock protein 20 in colorectal cancer and its implication in tumorigenesis.
Diagnostic, clinicopathologic, therapeutic and prognostic value of Plasma Heat Shock Protein 90 levels in patients with advanced Gastrointestinal Carcinoma.
Differential expression of HSP90 isoforms and their correlations with clinicopathologic factors in patients with colorectal cancer.
Differential proteomic analysis of human colorectal carcinoma cell lines metastasis-associated proteins.
Dihydropyrimidine Dehydrogenase Levels in Colorectal Cancer Cells Treated with a Combination of Heat Shock Protein 90 Inhibitor and Oxaliplatin or Capecitabine.
Discovery and Optimization of Small Molecules Targeting the Protein-Protein Interaction of Heat Shock Protein 90 (Hsp90) and Cell Division Cycle 37 as Orally Active Inhibitors for the Treatment of Colorectal Cancer.
Dominant high expression of wild-type HSP110 defines a poor prognostic subgroup of colorectal carcinomas with microsatellite instability: a whole-section immunohistochemical analysis.
Elevated levels of mitochondrial mortalin and cytosolic HSP70 in blood as risk factors in patients with colorectal cancer.
Exploiting the HSP60/10 chaperonin system as a chemotherapeutic target for colorectal cancer.
Expression of heat shock protein (Hsp) 70 and Hsp 40 in colorectal cancer.
FBW7-Dependent Mcl-1 Degradation Mediates the Anticancer Effect of Hsp90 Inhibitors.
Ganetespib, a novel Hsp90 inhibitor in patients with KRAS mutated and wild type, refractory metastatic colorectal cancer.
Gene Copy Number and Post-Transductional Mechanisms Regulate TRAP1 Expression in Human Colorectal Carcinomas.
Glucose regulated protein 78 (GRP78) is overexpressed in colorectal carcinoma and regulates colorectal carcinoma cell growth and apoptosis.
Glucose-regulated protein 78 contributes to the proliferation and tumorigenesis of human colorectal carcinoma via AKT and ERK pathways.
GRP78 enhances the glutamine metabolism to support cell survival from glucose deficiency by modulating the ?-catenin signaling.
GRP78 promoter polymorphism rs391957 as potential predictor for clinical outcome in gastric and colorectal cancer patients.
GRP78 regulates sensitivity of human colorectal cancer cells to DNA targeting agents.
Heat shock protein 105 peptide vaccine could induce antitumor immune reactions in a phase I clinical trial.
Heat shock protein 27 is associated with irinotecan resistance in human colorectal cancer cells.
Heat shock protein 47 promotes tumor survival and therapy resistance by modulating AKT signaling via PHLPP1 in colorectal cancer.
Heat shock protein 70 and HLA-DR molecules tissue expression. Prognostic implications in colorectal cancer.
Heat shock protein 70 is a useful marker for predicting colorectal cancer.
Heat shock protein 70-2 (HSP70-2) is a novel therapeutic target for colorectal cancer and is associated with tumor growth.
Heat Shock Protein 70s as Potential Molecular Targets for Colon Cancer Therapeutics.
Heat Shock Protein 90 Chaperone Regulates the E3 Ubiquitin-Ligase Hakai Protein Stability.
Heat shock protein 90 is involved in the regulation of HMGA2-driven growth and epithelial-to-mesenchymal transition of colorectal cancer cells.
Heat shock protein 90 promotes epithelial to mesenchymal transition, invasion, and migration in colorectal cancer.
Heat shock protein DNAJB8 is a novel target for immunotherapy of colon cancer-initiating cells.
High clusterin (CLU) mRNA expression levels in tumors of colorectal cancer patients predict a poor prognostic outcome.
High expression of HSP90 is associated with poor prognosis in patients with colorectal cancer.
How autophagy controls the intestinal epithelial barrier.
HSP60, a protein downregulated by IGFBP7 in colorectal carcinoma.
Hsp60: molecular anatomy and role in colorectal cancer diagnosis and treatment.
Hsp70 exerts oncogenic activity in the Apc mutant Min mouse model.
HSP90 inhibition downregulates thymidylate synthase and sensitizes colorectal cancer cell lines to the effect of 5FU-based chemotherapy.
HSP90 Inhibition Suppresses PGE2 Production via Modulating COX-2 and 15-PGDH Expression in HT-29 Colorectal Cancer Cells.
HSP90 inhibitor enhances anti-proliferative and apoptotic effects of celecoxib on HT-29 colorectal cancer cells via increasing BAX/BCL-2 ratio.
HSP90 inhibitor NVP-AUY922 enhances TRAIL-induced apoptosis by suppressing the JAK2-STAT3-Mcl-1 signal transduction pathway in colorectal cancer cells.
Identification of heat shock protein 90 and other proteins as tumour antigens by serological screening of an ovarian carcinoma expression library.
Identification of heat shock protein 90? as an IMH-2 epitope-associated protein and correlation of its mRNA overexpression with colorectal cancer metastasis and poor prognosis.
Identification of the circRNA-miRNA-mRNA regulatory network of Hsp90 inhibitor-induced cell death in colorectal cancer by integrated analysis.
Immunohistochemical detection of HSP27 and hnRNP K as prognostic and predictive biomarkers for colorectal cancer.
Increased Temperature Facilitates Adeno-Associated Virus Vector Transduction of Colorectal Cancer Cell Lines in a Manner Dependent on Heat Shock Protein Signature.
Induced oxidative stress and decreased expression of inducible heat shock protein 70 (ihsp 70) in patients with colorectal adenocarcinomas.
Inhibition of G1/S transition potentiates oxaliplatin-induced cell death in colon cancer cell lines.
Inhibition of heat shock protein 27 phosphorylation promotes sensitivity to 5-fluorouracil in colorectal cancer cells.
Inhibition of MEK sensitizes paclitaxel-induced apoptosis of human colorectal cancer cells by downregulation of GRP78.
Inhibition of the mitogen-activated protein kinase pathway results in the down-regulation of P-glycoprotein.
Knockdown of CEMIP suppresses proliferation and induces apoptosis in colorectal cancer cells: downregulation of GRP78 and attenuation of unfolded protein response.
Lipoproteins LDL versus HDL as nanocarriers to target either cancer cells or macrophages.
Low molecular weight heat shock protein HSP27 is a prognostic indicator in rectal cancer but not colon cancer.
Mitochondrial chaperone Trap1 and the calcium binding protein Sorcin interact and protect cells against apoptosis induced by antiblastic agents.
Molecular characterization of hsp90 isoforms in colorectal cancer cells and its association with tumour progression.
Mortalin contributes to colorectal cancer by promoting proliferation and epithelial-mesenchymal transition.
Mortalin is over-expressed by colorectal adenocarcinomas and correlates with poor survival.
Multi-panel assay of serum autoantibodies in colorectal cancer.
Nanofitins targeting heat shock protein 110: An innovative immunotherapeutic modality in cancer.
Natural killer and NK-Like T-cell activation in colorectal carcinoma patients treated with autologous tumor-derived heat shock protein 96.
Novel serum markers HSP60, CHI3L1, and IGFBP-2 in metastatic colorectal cancer.
Overexpression of GRP78 and GRP94 is involved in colorectal carcinogenesis.
Overexpression of the mitochondrial chaperone tumor necrosis factor receptor-associated protein 1 is associated with the poor prognosis of patients with colorectal cancer.
P53 and heat shock protein 70 expressions in colorectal adenocarcinoma.
Patients with colorectal tumors with microsatellite instability and large deletions in HSP110 T17 have improved response to 5-fluorouracil–based chemotherapy.
Plasma Levels of Heat Shock Protein 90 Alpha Associated With Colorectal Cancer Development.
Polymorphisms of glucose-regulated protein 78 and risk of colorectal cancer: a case-control study in southwest china.
Prediagnostic Helicobacter pylori Antibodies and Colorectal Cancer Risk in an Elderly, Caucasian Population.
Preoperative heat shock protein 47 levels identify colorectal cancer patients with lymph node metastasis and poor prognosis.
Priming of Anti-tumor Immune Mechanisms by Radiotherapy Is Augmented by Inhibition of Heat Shock Protein 90.
Prognostic significance of glucose-related protein 94 in colorectal cancer.
Proteomic analysis of Tiam1-mediated metastasis in colorectal cancer.
Proteomics analysis of differential protein expression identifies heat shock protein 47 as a predictive marker for lymph node metastasis in patients with colorectal cancer.
Proteomics-based identification of HSP60 as a tumor-associated antigen in colorectal cancer.
Quinazoline Based HSP90 Inhibitors: Synthesis, Modeling Study and ADME Calculations Towards Breast Cancer Targeting.
Radiolabeled F(ab')2-cetuximab for theranostic purposes in colorectal and skin tumor-bearing mice models.
Reconstructed mung bean trypsin inhibitor targeting cell surface GRP78 induces apoptosis and inhibits tumor growth in colorectal cancer.
Regulation of N-myristoyltransferase by novel inhibitor proteins.
Relationship between 18F-FDG uptake and heat shock protein 90? expression in colorectal cancer.
Role of Pluronic block copolymers in modulation of heat shock protein 70 expression.
Secreted Heat Shock Protein 90? (HSP90?) Induces Nuclear Factor-?B-mediated TCF12 Protein Expression to Down-regulate E-cadherin and to Enhance Colorectal Cancer Cell Migration and Invasion.
Secreted heat shock protein 90alpha induces colorectal cancer cell invasion through CD91/LRP-1 and NF-kappaB-mediated integrin alphaV expression.
Serum heat shock protein 90? have an advantage in diagnosis of colorectal cancer at early stage.
Serum level of soluble 70-kD heat shock protein is associated with high mortality in patients with colorectal cancer without distant metastasis.
Silencing Heat Shock Protein 27 Inhibits the Progression and Metastasis of Colorectal Cancer (CRC) by Maintaining the Stability of Stromal Interaction Molecule 1 (STIM1) Proteins.
Suppression of GRP78 sensitizes human colorectal cancer cells to oxaliplatin by downregulation of CD24.
Targeting of multiple oncogenic signaling pathways by Hsp90 inhibitor alone or in combination with berberine for treatment of colorectal cancer.
The 8.1 ancestral MHC haplotype is strongly associated with colorectal cancer risk.
The Association Between HSP90/topoisomerase I Immunophenotype and the Clinical Features of Colorectal Cancers in Respect to KRAS Gene Status.
The Clinical Value of HSP60 in Digestive System Cancers: a Systematic Review and Meta-Analysis.
The Cytotoxicity of Kahweol in HT-29 Human Colorectal Cancer Cells Is Mediated by Apoptosis and Suppression of Heat Shock Protein 70 Expression.
The HSP90 inhibitor ganetespib has chemosensitizer and radiosensitizer activity in colorectal cancer.
The interaction between SPARC and GRP78 interferes with ER stress signaling and potentiates apoptosis via PERK/eIF2? and IRE1?/XBP-1 in colorectal cancer.
The unfolded protein response regulator GRP78 is a novel predictive biomarker in colorectal cancer.
TLR4 is essential for dendritic cell activation and anti-tumor T-cell response enhancement by DAMPs released from chemically stressed cancer cells.
TRAP1 enhances Warburg metabolism through modulation of PFK1 expression/activity and favors resistance to EGFR inhibitors in human colorectal carcinomas.
TRAP1 protein signature predicts outcome in human metastatic colorectal carcinoma.
TRAP1 Regulates Wnt/?-Catenin Pathway through LRP5/6 Receptors Expression Modulation.
TRAP1, a novel mitochondrial chaperone responsible for multi-drug resistance and protection from apoptotis in human colorectal carcinoma cells.
UDP glucuronosyltransferase 1A expression levels determine the response of colorectal cancer cells to the heat shock protein 90 inhibitor ganetespib.
Up-regulation of mitochondrial chaperone TRAP1 in ulcerative colitis associated colorectal cancer.
USP22-dependent HSP90AB1 expression promotes resistance to HSP90 inhibition in mammary and colorectal cancer.
Vacuolar Membrane ATPase Activity 21 Predicts a Favorable Outcome and Acts as a Suppressor in Colorectal Cancer.
[Association between expressions of HSP70, HSP90 and efficacy of chemotherapy in colorectal cancer patients with unresectable liver metastasis]
[Closely relationship between expression of endoplasmic reticulum molecular chaperone Grp94 and c-myc oncogene in human colorectal carcinoma cell lines]
[Co-inhibition effect of 17-DMAG and oxaliplatin on proliferation and invasion of colorectal cancer cells].
[Differential expression of secretagogin and glucose-related protein 78 in colorectal carcinoma: a proteome study]
[Expression and clinical significance of 14-3-3 sigma and heat shock protein 27 in colorectal cancer]
[Expression of HSP27 in colorectal carcinoma and its relationship with lymphatic metastasis.]
[Expression of P53 and heat shock protein in colorectal tumors: an immunohistochemical study]
[Expressions of heat shock protein (HSP) family HSP 60, 70 and 90alpha in colorectal cancer tissues and their correlations to pathohistological characteristics.]
[Roles of glucose-regulated protein 78 in proliferation and migration of human colorectal carcinoma cell line RKO].
Coma
Mitochondrial heat shock protein 60 is increased in cerebrospinal fluid following pediatric traumatic brain injury.
Neuron-Specific Enolase, S100 Calcium-Binding Protein B, and Heat Shock Protein 70 Levels in Patients With Intracranial Hemorrhage.
Survival rate and expression of Heat-shock protein 70 and Frost genes after temperature stress in Drosophila melanogaster lines that are selected for recovery time from temperature coma.
The combination of exercise training and alpha-lipoic acid treatment has therapeutic effects on the pathogenic phenotypes of Alzheimer's disease in NSE/APPsw-transgenic mice.
Communicable Diseases
A non-receptor-mediated mechanism for internalization of molecular chaperones.
Binding of antigenic peptide to the endoplasmic reticulum-resident protein gp96/GRP94 heat shock chaperone occurs in higher order complexes. Essential role of some aromatic amino acid residues in the peptide-binding site.
Design and synthesis of Grp94 selective inhibitors based on Phe199 induced fit mechanism and their anti-inflammatory effects.
Extracellular heat shock protein 90: a role for a molecular chaperone in cell motility and cancer metastasis.
Functional role of Hsp60 as a positive regulator of human viral infection progression.
Functions of the Hsp90 chaperone system: lifting client proteins to new heights.
Hansenula polymorpha expressed heat shock protein gp96 exerts potent T cell activation activity as an adjuvant.
Harnessing Hsp90 function as a powerful, broadly effective therapeutic strategy for fungal infectious disease.
Heat shock protein 90 from neglected protozoan parasites.
Heat Shock Protein 90 Inhibitors as Broad Spectrum Anti-infectives.
Heat-shock protein 70 gene sequencing for Leishmania species typing in European tropical infectious disease clinics.
Homogeneous Escherichia coli chaperonin 60 induces IL-1 beta and IL-6 gene expression in human monocytes by a mechanism independent of protein conformation.
Hsp100 Molecular Chaperone ClpB and Its Role in Virulence of Bacterial Pathogens.
HSP60: issues and insights on its therapeutic use as an immunoregulatory agent.
Hsp90 orchestrates temperature-dependent candida albicans morphogenesis via Ras1-PKA signaling.
Interaction of Toll-Like Receptors with the Molecular Chaperone Gp96 Is Essential for Its Activation of Cytotoxic T Lymphocyte Response.
Mechanism and Complex Roles of HSC70 in Viral Infections.
Plasma membrane expression of heat shock protein 60 in vivo in response to infection.
Polymorphism in heat-shock protein 70-1 (HSP70-1) gene promoter region and susceptibility to tuberculoid leprosy and pulmonary tuberculosis in Asian Indians.
Relationships between the onset of pustulosis palmaris et plantaris, periodontitis and bacterial heat shock proteins.
Secreted heat shock protein gp96-Ig: next-generation vaccines for cancer and infectious diseases.
Significance of serum antibodies against HSP 60 and HSP 70 for the diagnostic of infectious diseases.
Targeting Heat Shock Protein 90 for Malaria.
TAT-mediated gp96 transduction to APCs enhances gp96-induced antiviral and antitumor T cell responses.
The common heat shock protein receptor CD91 is up-regulated on monocytes of advanced melanoma slow progressors.
The evolution of fungal drug resistance: modulating the trajectory from genotype to phenotype.
The regulatory mechanism of Hsp90alpha secretion from endothelial cells and its role in angiogenesis during wound healing.
The universe of Hsp90.
[Role of heat shock protein-peptide complexes on tumor and infectious diseases immunity]
Confusion
Guidelines for the nomenclature of the human heat shock proteins.
Congenital Abnormalities
Characterization of heat shock protein 40 and 90 in Chironomus riparius larvae: effects of di(2-ethylhexyl) phthalate exposure on gene expressions and mouthpart deformities.
Hsp90 and complex birth defects: A plausible mechanism for the interaction of genes and environment.
Recovery of Chicken Growth Plate by Heat-Shock Protein 90 Inhibitors Epigallocatechin-3-Gallate and Apigenin in Thiram-Induced Tibial Dyschondroplasia.
Repercussion of Mitochondria Deformity Induced by Anti-Hsp90 Drug 17AAG in Human Tumor Cells.
Congenital Hypothyroidism
DNAJC17 is localized in nuclear speckles and interacts with splicing machinery components.
Conjunctivitis, Inclusion
Systemic immunization with Hsp60 alters the development of chlamydial ocular disease.
Contracture
Auxiliary proteins that facilitate formation of collagen-rich deposits in the posterior knee capsule in a rabbit-based joint contracture model.
Corneal Dystrophies, Hereditary
A novel proteotoxic stress associated mechanism for macular corneal dystrophy.
Corneal Opacity
The relationship between rabbit corneal opacity and immunohistochemical expression of heat shock protein 72/73 and c-fos after excimer laser photorefractive keratectomy.
Coronary Artery Disease
A cross-sectional study of the association between heat shock protein 27 antibody titers, pro-oxidant-antioxidant balance and metabolic syndrome in patients with angiographically-defined coronary artery disease.
Acute Chlamydia pneumoniae infection with heat-shock-protein-60-related response in patients with acute coronary syndrome.
An Aggregate Biomarker Risk Score Predicts High Risk of Near-Term Myocardial Infarction and Death: Findings From BARI 2D (Bypass Angioplasty Revascularization Investigation 2 Diabetes).
Anti-Heat Shock Protein 27 Titers and Oxidative Stress Levels are Elevated in Patients With Valvular Heart Disease.
Antibodies against the human heat shock protein hsp70 in patients with severe coronary artery disease.
Antibodies to human heat-shock protein 60 are associated with the presence and severity of coronary artery disease: evidence for an autoimmune component of atherogenesis.
Association between antibodies to heat shock protein 65 and coronary atherosclerosis. Possible mechanism of action of Helicobacter pylori and other bacterial infections in increasing cardiovascular risk.
Association of heat shock protein polymorphisms with patient susceptibility to coronary artery disease comorbid depression and anxiety in a Chinese population.
Association of heat shock protein70-2 (HSP70-2) gene polymorphism with coronary artery disease in an Iranian population.
Chronic Infections and Atherosclerosis.
Heat-shock protein 60 and cardiovascular disease: a paradoxical role.
Hormone replacement therapy increases levels of antibodies against heat shock protein 65 and certain species of oxidized low density lipoprotein.
Hsp70-2 gene polymorphism: susceptibility implication in Tunisian patients with coronary artery disease.
Implications of antibodies to heat-shock proteins in ischemic heart disease.
Increased serum levels of heat shock protein 70 are associated with low risk of coronary artery disease.
Independent and joint effects of antibodies to human heat-shock protein 60 and Chlamydia pneumoniae infection in the development of coronary atherosclerosis.
Inverse association of ApoB and HSP60 antibodies with coronary artery disease in Indian population.
Involvement of -308 TNF-alpha and 1267 Hsp70-2 polymorphisms and zinc status in the susceptibility of coronary artery disease (CAD) in old patients.
Plasma heat shock protein 27 is associated with coronary artery disease, abdominal aortic aneurysm and peripheral artery disease.
Plasma heat shock protein 60 and cardiovascular disease risk: the role of psychosocial, genetic, and biological factors.
Prevalence of intimal heat shock protein 60 homologues in unstable angina and correlation with anti-heat shock protein antibody titers.
Serum antibody titers against heat shock protein 27 are associated with the severity of coronary artery disease.
Serum immunoglobulin G antibodies to chlamydial heat shock protein 60 but not to human and bacterial homologs are associated with coronary artery disease.
Tissue MicroArray (TMA) analysis of normal and persistent Chlamydophila pneumoniae infection.
[Chlamydial and human heat shock protein 60 homologues in acute coronary syndromes. (Auto-)immune reactions as a link between infection and atherosclerosis]
Coronary Disease
Analysis of the association of a heat shock protein70-1 gene promoter polymorphism with myocardial infarction and coronary risk traits.
Antibodies against human heat-shock protein (hsp) 60 and mycobacterial hsp65 differ in their antigen specificity and complement-activating ability.
Antibodies to 60-kilodalton heat shock protein and outer membrane protein 2 of Chlamydia pneumoniae in patients with coronary heart disease.
Antibody response to chlamydial heat shock protein 60 is strongly associated with acute coronary syndromes.
Association between plasma levels of heat shock protein 60 and cardiovascular disease in patients with diabetes mellitus.
Autoantibodies to a specific peptide epitope of human Hsp60 (ATVLA) with homology to Helicobacter pylori HspB in H. pylori-infected patients.
Chlamydia pneumoniae, heat shock proteins 60 and risk of secondary cardiovascular events in patients with coronary heart disease under special consideration of diabetes : a prospective study.
Comparative study on antibodies to human and bacterial 60 kDa heat shock proteins in a large cohort of patients with coronary heart disease and healthy subjects.
Complement activating antibodies against the human 60 kDa heat shock protein as a new independent family risk factor of coronary heart disease.
Expression of heat shock proteins and nitrotyrosine in small arteries from patients with coronary heart disease.
Genetic variation in heat shock protein 60 gene and coronary heart disease in China: tagging-SNP haplotype analysis in a case-control study.
Genetic variations in HSPA8 gene associated with coronary heart disease risk in a Chinese population.
The relationship between carotid stiffness and circulating levels of heat shock protein 60 in middle-aged men and women.
Coronary Occlusion
Attenuation of heat shock protein expression by coronary occlusion in hypertrophied hearts.
Differential stress protein mRNA expression during early ischaemic preconditioning in the rabbit heart and its relationship to adenosine receptor function.
Identification of a NF-?B cardioprotective gene program: NF-?B regulation of Hsp70.1 contributes to cardioprotection after permanent coronary occlusion.
Role of heat shock protein 90 and endothelial nitric oxide synthase during early anesthetic and ischemic preconditioning.
Coronavirus Infections
Middle East respiratory syndrome coronavirus and bat coronavirus HKU9 both can utilize GRP78 for attachment onto host cells.
The stress-inducible molecular chaperone GRP78 as potential therapeutic target for coronavirus infection.
Corticobasal Degeneration
The Small Heat Shock Protein HSP25/27 (HspB1) Is Abundant in Cultured Astrocytes and Associated with Astrocytic Pathology in Progressive Supranuclear Palsy and Corticobasal Degeneration.
COVID-19
A connectivity map-based drug repurposing study and integrative analysis of transcriptomic profiling of SARS-CoV-2 infection.
A possible role for GRP78 in cross vaccination against COVID-19.
Are Hsp90 inhibitors good candidates against Covid-19?
Cancer progression in COVID-19: integrating the roles of renin angiotensin aldosterone system, angiopoietin-2, heat shock protein-27 and epithelial mesenchymal transition.
COVID-19 and hypertension: is the HSP60 culprit for the severe course and worse outcome?
COVID-19 spike-host cell receptor GRP78 binding site prediction.
Covid-19, heat shock proteins, and autoimmune bullous diseases: a potential link deserving further attention.
COVID-19: Is There a Link between Alcohol Abuse and SARS-CoV-2-Induced Severe Neurological Manifestations?
COVID19 associated mucormycosis: Is GRP78 a possible link?
Does the compromised sleep and circadian disruption of night and shiftworkers make them highly vulnerable to 2019 coronavirus disease (COVID-19)?
Endoplasmic Reticulum Stress Markers in SARS-COV-2 Infection and Pneumonia: Case-Control Study.
Evaluation of vertical transmission of SARS-CoV-2 in utero: Nine pregnant women and their newborns.
Gene expression and in situ protein profiling of candidate SARS-CoV-2 receptors in human airway epithelial cells and lung tissue.
High GRP78 levels in Covid-19 infection: A case-control study.
Hsp90 inhibition protects the brain microvascular endothelium against oxidative stress.
Inflammation Profiling of Critically Ill Coronavirus Disease 2019 Patients.
Is There any Alternative Receptor for SARS-CoV-2?
Novel Sigma 1 Receptor Antagonists as Potential Therapeutics for Pain Management.
Pneumocytes are distinguished by highly elevated expression of the ER stress biomarker GRP78, a co-receptor for SARS-CoV-2, in COVID-19 autopsies.
Predicted therapeutic targets for COVID-19 disease by inhibiting SARS-CoV-2 and its related receptors.
Preliminary Virtual Screening Studies to Identify GRP78 Inhibitors Which May Interfere with SARS-CoV-2 Infection.
SARS-CoV-2 Infection-Induced Promoter Hypomethylation as an Epigenetic Modulator of Heat Shock Protein A1L (HSPA1L) Gene.
The chaperone GRP78 is a host auxiliary factor for SARS-CoV-2 and GRP78 depleting antibody blocks viral entry and infection.
Transcriptomic profiling of SARS-CoV-2 infected human cell lines identifies HSP90 as target for COVID-19 therapy.
Ubiquitin-Modified Proteome of SARS-CoV-2-Infected Host Cells Reveals Insights into Virus-Host Interaction and Pathogenesis.
Coxsackievirus Infections
[The correlation research on miRNA378* and calumenin,endoplasmic reticulum stress,apoptosis in suckling mouse myocardial cells infected with coxsackie virus B3].
Craniocerebral Trauma
Alterations in inducible 72-kDa heat shock protein and the chaperone cofactor BAG-1 in human brain after head injury.
Creutzfeldt-Jakob Syndrome
Creutzfeldt-Jakob disease: heat shock protein 70 mRNA levels in mononuclear blood cells and clinical study.
Crohn Disease
Absence of ABCG2-mediated mucosal detoxification in patients with active inflammatory bowel disease is due to impeded protein folding.
Autoimmunity to heat shock protein 40 in ulcerative colitis.
Cellular and humoral immunity to the 60-kD heat shock protein in inflammatory bowel disease.
Crohn's disease and polymorphism of heat shock protein gene HSP70-2 in the Chinese population.
Crohn's disease and polymorphism of heat shock protein gene HSP70-2 in the Tunisian population.
Detection of mycobacteria in Crohn's disease by a broad spectrum polymerase chain reaction.
Evidence for T lymphocyte reactivity to the 65 kilodalton heat shock protein of mycobacterium in active Crohn's disease.
Gp96 Peptide Antagonist gp96-II Confers Therapeutic Effects in Murine Intestinal Inflammation.
Heat shock protein 47 is a new candidate molecule as anti-fibrotic treatment of Crohn's disease.
Heat shock protein 90 and inflammatory activity in newly onset Crohn's disease.
Heat shock protein family A member 6 combined with clinical characteristics for the differential diagnosis of intestinal Behçet's disease.
Heat shock protein gene 70-2 polymorphism is differentially associated with the clinical phenotypes of ulcerative colitis and Crohn's disease.
Heat-shock protein HSP70-2 genotypes in patients with Crohn's disease: a more severe clinical course with intestinal complications in presence of the PstI-polymorphism.
How autophagy controls the intestinal epithelial barrier.
Hsp60 and Hsp10 increase in colon mucosa of Crohn's disease and ulcerative colitis.
Impaired humoral immune response against mycobacterial 65-kDa heat shock protein (HSP65) in patients with inflammatory bowel disease.
Increased Levels of Survivin, via Association With Heat Shock Protein 90, in Mucosal T Cells From Patients With Crohn's Disease.
Intestinal expression and cellular immune responses to human heat-shock protein 60 in Crohn's disease.
Intestinal expression of human heat shock protein 90 in patients with Crohn's disease and ulcerative colitis.
Involvement of interleukin-17A-induced expression of heat shock protein 47 in intestinal fibrosis in Crohn's disease.
Mucosal expression by B7-positive cells of the 60-kilodalton heat-shock protein in inflammatory bowel disease.
Polymorphism of heat-shock protein gene HSP70-2 in Crohn disease: possible genetic marker for two forms of Crohn disease.
Polymorphism of the heat-shock protein gene Hsp70-2, but not polymorphisms of the IL-10 and CD14 genes, is associated with the outcome of Crohn's disease.
RNF186 regulates EFNB1 (ephrin B1)-EPHB2-induced autophagy in the colonic epithelial cells for the maintenance of intestinal homeostasis.
The molecular chaperone HSP70 binds to and stabilizes NOD2, an important protein involved in Crohn disease.
Tumour necrosis factor-alpha production stimulated by heat shock protein 70 and its inhibition in circulating dendritic cells and cells eluted from mucosal tissues in Crohn's disease.
Cryptococcosis
A 77-kilodalton protein of Cryptococcus neoformans, a member of the heat shock protein 70 family, is a major antigen detected in the sera of mice with pulmonary cryptococcosis.
Heat shock protein 70 (hsp70) as a major target of the antibody response in patients with pulmonary cryptococcosis.
Cryptogenic Organizing Pneumonia
Involvement of collagen-binding heat shock protein 47 and procollagen type I synthesis in idiopathic pulmonary fibrosis: contribution of type II pneumocytes to fibrosis.
Cryptorchidism
EVEN-PLUS syndrome: A case report with novel variants in HSPA9 and evidence of HSPA9 gene dysfunction.
Expression of HSP70-2 gene during germ cell apoptosis in rat unilateral cryptorchid testes.
Inducible 70 kDa heat shock protein does not protect spermatogenic cells from damage induced by cryptorchidism.
Cryptosporidiosis
Survey of Cryptosporidium parvum genotypes in humans from the UK by mutation scanning analysis of a heat shock protein gene region.
Cushing Syndrome
Impaired wound healing in Cushing's syndrome: the role of heat shock proteins.
Cyclosporiasis
Genetic similarities between Cyclospora cayetanensis and cecum-infecting avian Eimeria spp. in apicoplast and mitochondrial genomes.
Cystic Fibrosis
A new role for heat shock factor 27 in the pathophysiology of Clostridium difficile toxin B.
A small molecule that binds to an ATPase domain of Hsc70 promotes membrane trafficking of mutant cystic fibrosis transmembrane conductance regulator.
Antibodies to human HSP60 in patients with juvenile chronic arthritis, diabetes mellitus, and cystic fibrosis.
Autoantibodies to pancreatic hsp60 precede the development of glucose intolerance in patients with cystic fibrosis.
Avidity of anti-P aeruginosa antibodies during chronic infection in patients with cystic fibrosis.
BAG-2 acts as an inhibitor of the chaperone-associated ubiquitin ligase CHIP.
Biological and structural basis for Aha1 regulation of Hsp90 ATPase activity in maintaining proteostasis in the human disease cystic fibrosis.
Coupling cystic fibrosis to endoplasmic reticulum stress: Differential role of Grp78 and ATF6.
Deletion of Phe508 in the first nucleotide-binding domain of the cystic fibrosis transmembrane conductance regulator increases its affinity for the heat shock cognate 70 chaperone.
Distinct roles for the Hsp40 and Hsp90 molecular chaperones during cystic fibrosis transmembrane conductance regulator degradation in yeast.
Extreme winter cold-induced osmoregulatory, metabolic, and physiological responses in European seabass (Dicentrarchus labrax) acclimatized at different salinities.
How autophagy controls the intestinal epithelial barrier.
Hsp104 facilitates the endoplasmic-reticulum-associated degradation of disease-associated and aggregation-prone substrates.
Hsp70 molecular chaperone facilitates endoplasmic reticulum-associated protein degradation of cystic fibrosis transmembrane conductance regulator in yeast.
Hsp90 and client protein maturation.
Hsp90 cochaperone Aha1 downregulation rescues misfolding of CFTR in cystic fibrosis.
Human heat shock protein 105/110 kDa (Hsp105/110) regulates biogenesis and quality control of misfolded cystic fibrosis transmembrane conductance regulator at multiple levels.
Localization of the BiP molecular chaperone with respect to endoplasmic reticulum foci containing the cystic fibrosis transmembrane conductance regulator in yeast.
Non-native Conformers of Cystic Fibrosis Transmembrane Conductance Regulator NBD1 Are Recognized by Hsp27 and Conjugated to SUMO-2 for Degradation.
Participation of the endoplasmic reticulum chaperone calnexin (p88, IP90) in the biogenesis of the cystic fibrosis transmembrane conductance regulator.
Relative increase in IgG antibodies to Pseudomonas aeruginosa 60-kDa GroEL in prediabetic patients with cystic fibrosis.
Role of Hsc70 binding cycle in CFTR folding and endoplasmic reticulum-associated degradation.
Small changes in gene expression of targeted osmoregulatory genes when exposing marine and freshwater threespine stickleback (Gasterosteus aculeatus) to abrupt salinity transfers.
Sodium 4-phenylbutyrate downregulates Hsc70: implications for intracellular trafficking of DeltaF508-CFTR.
The clonal antibody response to Pseudomonas aeruginosa heat shock protein is highly diverse in cystic fibrosis patients.
The molecular chaperone Hsc70 assists the in vitro folding of the N-terminal nucleotide-binding domain of the cystic fibrosis transmembrane conductance regulator.
Cysts
A proteomic study on postdiapaused embryonic development of brine shrimp (Artemia franciscana).
A role of carboxy-terminal region of Toxoplasma gondii-heat shock protein 70 in enhancement of T. gondii infection in mice.
Acanthamoeba castellanii: Gene profile of encystation by ESTs analysis and KOG assignment.
Artemin, a Diapause-Specific Chaperone, Contributes to the Stress Tolerance of Artemia Cysts and Influences Their Release from Females.
Changes in the expression of Heat Shock Proteins in ovaries from bovines with cystic ovarian disease induced by ACTH.
Chronic ingestion of high dosed Phikud Navakot extraction induces mesangiolysis in rats with alteration of AQP1 and Hsp60 expressions.
Cyst viability and stress tolerance upon heat shock protein 70 knockdown in the brine shrimp Artemia franciscana.
Expression of a 66-kD heat shock protein associated with the process of cyst formation of a true slime mold, Physarum polycephalum.
Ganetespib limits ciliation and cystogenesis in autosomal-dominant polycystic kidney disease (ADPKD).
Inhibiting heat shock protein 90 (HSP90) limits the formation of liver cysts induced by conditional deletion of Pkd1 in mice.
Inhibiting the HSP90 chaperone slows cyst growth in a mouse model of autosomal dominant polycystic kidney disease.
Isolation of Toxoplasma gondii development mutants identifies a potential proteophosphogylcan that enhances cyst wall formation.
Knockdown of the Small Heat Shock Protein, p26 by RNA Interference Modifies the Diapause Proteome of Artemia franciscana.
Levels of heat shock protein transcripts in normal follicles and ovarian follicular cysts.
Mitosomes in trophozoites and cysts of the reptilian parasite Entamoeba invadens.
Molecular chaperones, stress resistance and development in Artemia franciscana.
Overexpression and extra-mitochondrial localization of the chaperonin Hsp60 in ameloblastoma.
Post-diapause synthesis of ArHsp40-2, a type 2 J-domain protein from Artemia franciscana, is developmentally regulated and induced by stress.
Profiling and quantifying differential gene transcription in Phytophthora infestans prior to and during the early stages of potato infection.
Research on plant-parasitic nematode biology conducted by the United States Department of Agriculture-Agricultural Research Service.
Stress tolerance during diapause and quiescence of the brine shrimp, Artemia.
The consensus Nglyco -X-S/T motif and a previously unknown Nglyco -N-linked glycosylation are necessary for growth and pathogenicity of Phytophthora.
The Small Heat Shock Protein p26 Aids Development of Encysting Artemia Embryos, Prevents Spontaneous Diapause Termination and Protects against Stress.
Therapeutic Potential for CFTR Correctors in Autosomal Recessive Polycystic Kidney Disease.
Water-structuring technology with the molecular chaperone proteins: indicated application of the ?-crystallin domains and imidazole-containing peptidomimetics in cosmetic skin care systems or dermatological therapeutic drug carrier formulations.
[Heat shock protein of HSP70 family revealed in some contemporary freshwater Amoebae and in Acanthamoeba sp. from cysts isolated from permafrost samples]
Cytomegalovirus Infections
Interaction of antibodies against cytomegalovirus with heat-shock protein 60 in pathogenesis of atherosclerosis.
NSF, Unc-18-1, dynamin-1 and HSP90 are inclusion body components in neuronal intranuclear inclusion disease identified by anti-SUMO-1-immunocapture.
Prenatal diagnosis of congenital cytomegalovirus infection by detection of immunoglobulin M antibodies to the 70-kd heat shock protein in fetal serum.
Role of the endoplasmic reticulum chaperone BiP, SUN domain proteins, and dynein in altering nuclear morphology during human cytomegalovirus infection.
Deafness
Ahsa1 and Hsp90 activity confers more severe craniofacial phenotypes in a zebrafish model of hypoparathyroidism, sensorineural deafness and renal dysplasia (HDR).
Decompression Sickness
Heat-shock protein 70 is involved in hyperbaric oxygen preconditioning on decompression sickness in rats.
MEK1/2 Inhibition Synergistically Enhances the Preventive Effects of Normobaric Oxygen on Spinal Cord Injury in Decompression Sickness Rats.
Dehydration
Bulk analysis by resequencing and RNA-seq identifies candidate genes for maintaining leaf water content under water deficit in maize.
Changes in markers of muscle damage, inflammation and HSP70 after an Ironman Triathlon race.
Cloning of new members of heat shock protein HSP101 gene family in wheat (Triticum aestivum (L.) Moench) inducible by heat, dehydration, and ABA(1).
Dehydration stress alters the mitogen-activated-protein kinase signaling and chaperone stress response in Xenopus laevis.
Dehydration-induced DnaK2 Chaperone Is Involved in PSII Repair of a Desiccation-tolerant Cyanobacterium.
Heat shock proteins contribute to mosquito dehydration tolerance.
In defense of proteins: Chaperones respond to freezing, anoxia, or dehydration stress in tissues of freeze tolerant wood frogs.
Induction of Heat Shock Protein Messenger RNA in Maize Mesocotyls by Water Stress, Abscisic Acid, and Wounding.
Involvement of ascorbate peroxidase and heat shock proteins on citrus tolerance to combined conditions of drought and high temperatures.
LEA proteins prevent protein aggregation due to water stress.
Mammalian HSP60 is quickly sorted into the mitochondria under conditions of dehydration.
Preservative Effect of Polyols on the Stability of Biocatalysts during Short-term Dehydration Stress
Responses of the bed bug, Cimex lectularius, to temperature extremes and dehydration: levels of tolerance, rapid cold hardening and expression of heat shock proteins.
Targeting conserved co-opted host factors to block virus replication: Using allosteric inhibitors of the cytosolic Hsp70s to interfere with tomato bushy stunt virus replication.
The effect of dehydration on muscle metabolism and time trial performance during prolonged cycling in males.
The regulation of heat shock proteins in response to dehydration in Xenopus laevis.
The response of Asterochloris erici (Ahmadjian) Skaloud et Peksa to desiccation: a proteomic approach.
Uncovering the basis of viability loss in desiccation sensitive Trichilia dregeana seeds using differential quantitative protein expression profiling by iTRAQ.
[Construction and analysis of subtractive cDNA library of Phellodendron amurense under drought stress]
Delirium
Autopsy-proven Mirtazapine Withdrawal-induced Mania/Hypomania Associated with Sudden Death.
Commentary on: Johnson MM, David JA, Michelhaugh SK, Schmidt CJ, Bannon MJ. Increased heat shock protein 70 gene expression in the brains of cocaine-related fatalities may be reflective of postdrug survival and intervention rather than excited delirium. J Forensic Sci 2012;57(6):1519-23.
Genome-wide association study of myocardial infarction, atrial fibrillation, acute stroke, acute kidney injury and delirium after cardiac surgery - a sub-analysis of the RIPHeart-Study.
Increased Heat Shock Protein 70 Gene Expression in the Brains of Cocaine-Related Fatalities may be Reflective of Postdrug Survival and Intervention rather than Excited Delirium.
Dementia
Dementia related Bri2 BRICHOS is a versatile molecular chaperone that efficiently inhibits A?42 toxicity in Drosophila.
Heat shock protein 70 and tumor necrosis factor alpha in Taiwanese patients with dementia.
Heat shock protein 70 mRNA levels in mononuclear blood cells from patients with dementia of the Alzheimer type.
HSP90 and Its Novel Co-Chaperones, SGT1 and CHP-1, in Brain of Patients with Parkinson's Disease and Dementia with Lewy Bodies.
Oral Administration of Lipopolysaccharide Prevents Cognitive Impairment in Streptozotocin-induced Diabetic Mice in a Blood Glucose-independent Manner.
Stress protein inclusions in cerebral vessels in dialysis encephalopathy.
Dementia, Vascular
Heat shock protein 70 and tumor necrosis factor alpha in Taiwanese patients with dementia.
Demyelinating Diseases
Anti-alpha B-crystallin immunoreactivity in inflammatory nervous system diseases.
Antibodies reactive to heat shock protein 90 induce oligodendrocyte precursor cell death in culture. Implications for demyelination in multiple sclerosis.
Heat shock protein immunoreactivity in CSF: correlation with oligoclonal banding and demyelinating disease.
Induction of Heat Shock Protein 70 (Hsp70) prevents neuregulin-induced demyelination by enhancing the proteasomal clearance of c-Jun.
Induction of heat shock protein 70 (Hsp70) prevents neuregulin-induced demyelination by enhancing the proteasomal clearance of c-Jun.
Intrathecal heat shock protein 60 mediates neurodegeneration and demyelination in the CNS through a TLR4- and MyD88-dependent pathway.
miR-155-3p Drives the Development of Autoimmune Demyelination by Regulation of Heat Shock Protein 40.
New Cortical Neurodegenerative Pathways in the Hypertensive Rat Brain.
Targeting Heat Shock Protein 70 to Ameliorate c-Jun Expression and Improve Demyelinating Neuropathy.
Tumor necrosis factor-alpha and alphaB-crystallin up-regulation during antibody-mediated demyelination in vitro: a putative protective mechanism in oligodendrocytes.
Dengue
A synthetic dengue virus antigen elicits enhanced antibody titers when linked to, but not mixed with, Mycobacterium tuberculosis HSP70 domain II.
AR-12 suppresses dengue virus replication by down-regulation of PI3K/AKT and GRP78.
Dengue virus entry into liver (HepG2) cells is independent of hsp90 and hsp70.
Dengue virus infection induces GRP78 which acts to chaperone viral antigen production.
GRP78: a chaperone with diverse roles beyond the endoplasmic reticulum.
GRP78: a multifunctional receptor on the cell surface.
Heat shock protein 90 and heat shock protein 70 are components of dengue virus receptor complex in human cells.
Hsp90 interacts with multiple dengue virus 2 proteins.
Identification of GRP 78 (BiP) as a liver cell expressed receptor element for dengue virus serotype 2.
RNA interference mediated inhibition of dengue virus multiplication and entry in HepG2 cells.
RNA interference mediated silencing of Hsp60 gene in human monocytic myeloma cell line U937 revealed decreased dengue virus multiplication.
Role of human GRP75 in miRNA mediated regulation of dengue virus replication.
Small Molecule Inhibitor of ATPase Activity of HSP70 as a Broad-Spectrum Inhibitor against Flavivirus Infections.
Dental Caries
Heat Shock 70 Protein Genes and Genetic Susceptibility to Apical Periodontitis.
Dental Plaque
Inhibitory effects of low-energy pulsed ultrasonic stimulation on cell surface protein antigen C through heat shock proteins GroEL and DnaK in Streptococcus mutans.
The effect of IL-4 gene polymorphisms on cytokine production in patients with chronic periodontitis and in healthy controls.
Dental Pulp Calcification
Near-reciprocal phenotypes caused by inactivation or indiscriminate expression of the Drosophila segmentation gene ftz.
Dermatitis
Bacterial infection and tissue-specific Hsp72, -73 and -90 expression in western painted turtles.
Dermatitis Herpetiformis
Evidence for a role of autoantibodies to heat shock protein 60, 70, and 90 in patients with dermatitis herpetiformis.
Heat shock protein 90: a pathophysiological factor and novel treatment target in autoimmune bullous skin diseases.
Dermatitis, Atopic
Circulating heat shock protein 90 (Hsp90) and autoantibodies to Hsp90 are increased in patients with atopic dermatitis.
Expression of 27 KD, 65 KD and 72/73 KD heat shock protein in atopic dermatitis: comparison with those in normal skin and contact dermatitis.
Heat Shock Protein 27 kDa Content in Stratum Corneum Correlates with Severity of Atopic Dermatitis.
Heat shock protein HSP40 family chaperone DNAJB6/MRJ expression analysis in blood cells obtained from patients with atopic dermatitis in different phases.
Intradermal injection of Hsp60 induces cytokine responses in canine atopic and healthy skin.
Recognition of self-heat shock protein 60 by T cells from patients with atopic dermatitis.
Subcutaneous injection of recombinant heat shock protein 70 ameliorates atopic dermatitis skin lesions in a mouse model.
[Expression of HSP60, TLR4 and NF-kappaBp65 in the peripheral blood of patients with atopic dermatitis]
Dermatitis, Contact
Attenuation of contact hypersensitivity by cell-permeable heat shock protein 70 in BALB/c mouse model.
Expression of 27 KD, 65 KD and 72/73 KD heat shock protein in atopic dermatitis: comparison with those in normal skin and contact dermatitis.
Dermatomyositis
A dual role for HSP90 and HSP70 in the inflammatory myopathies: from muscle fiber protection to active invasion by macrophages.
Expression of heat-shock/stress proteins in Duchenne muscular dystrophy.
Heat-shock protein 90 and ubiquitin: developmental regulation during myogenesis.
Hsp60 in inflamed muscle tissue is the target of regulatory autoreactive T cells in patients with juvenile dermatomyositis.
Incidence of anti Hsp 90 and 70 antibodies in children with SLE, juvenile dermatomyositis and juvenile chronic arthritis.
[Expression of the heat shock protein 70 in inflammatory myopathies]
Diabetes Complications
Enhanced degradation and decreased stability of eye lens alpha-crystallin upon methylglyoxal modification.
Heat shock protein 60 (HSP60) modulates adiponectin signaling by stabilizing adiponectin receptor.
Serum heat shock protein 27 and diabetes complications in the EURODIAB prospective complications study: a novel circulating marker for diabetic neuropathy.
Targeting HSP90 Ameliorates Nephropathy and Atherosclerosis Through Suppression of NF-?B and STAT Signaling Pathways in Diabetic Mice.
Diabetes Insipidus, Nephrogenic
Hsp90 inhibitor partially corrects nephrogenic diabetes insipidus in a conditional knock-in mouse model of aquaporin-2 mutation.
Diabetes Mellitus
A model integrating donor gene polymorphisms predicts fibrosis after liver transplantation.
Acetylation of Hsp90 reverses dexamethasone-mediated inhibition of insulin secretion.
Antibodies against different epitopes of heat-shock protein 60 in children with type 1 diabetes mellitus.
Antibodies to heat shock protein 65 kD in type 1 diabetes mellitus.
Antibodies to heat-shock protein 65 and neopterin levels in patients with type 1 diabetes mellitus.
Antibodies to human HSP60 in patients with juvenile chronic arthritis, diabetes mellitus, and cystic fibrosis.
Chaperone-Based Therapeutic Target Innovation: Heat Shock Protein 70 (HSP70) for Type 2 Diabetes Mellitus.
Chlamydia pneumoniae, heat shock proteins 60 and risk of secondary cardiovascular events in patients with coronary heart disease under special consideration of diabetes : a prospective study.
Complement C4 and heat shock protein 70 (HSP70) genotypes and type I diabetes mellitus.
Detection of Hsp60 in saliva and serum from type 2 diabetic and non-diabetic control subjects.
Does Hsp60 Provide a Link between Mitochondrial Stress and Inflammation in Diabetes Mellitus?
Effect of heat shock protein peptide DiaPep277 on beta-cell function in paediatric and adult patients with recent-onset diabetes mellitus type 1: two prospective, randomized, double-blind phase II trials Nanette C. Schloot, Guido Meierhoff, Csaba Lengyel, Gyözö Vándorfi, József Takács, Pál Pánczél, László Barkai, László Madácsy, Tamás Oroszlán, Peter Kovács, Gábor Sütö, Tadej Battelino, Nora Hosszufalusi, György Jermendy. Diabetes/Metabolism Research and Reviews 2006.
Effect of heat shock protein peptide DiaPep277 on beta-cell function in paediatric and adult patients with recent-onset diabetes mellitus type 1: two prospective, randomized, double-blind phase II trials.
Endothelial TNF-? induction by Hsp60 secreted from THP-1 monocytes exposed to hyperglycaemic conditions.
Express ELISA for detection of mortalin.
Glutamine enhances the heat shock protein 70 expression as a cardioprotective mechanism in left heart tissues in the presence of diabetes mellitus.
Heat Shock Protein 70 Gene Polymorphism in Egyptian Patients with Type 2 Diabetes Mellitus, with and without Nephropathy.
Heat Shock Protein HSP60 in Left Ventricular Cardiomyocytes of Hypertensive Rats with and without Insulin-Dependent Diabetes Mellitus.
Heat shock protein-70 and hypoxia inducible factor-1? in type 2 diabetes mellitus patients complicated with retinopathy.
Higher urine heat shock protein 70/creatinine ratio in type 1 diabetes mellitus.
Is heat shock protein 60 associated with type 2 diabetes mellitus?
Ischemic preconditioning phosphorylates mitogen-activated kinases and heat shock protein 27 in the diabetic rat heart.
Mild Electrical Stimulation with Heat Shock Reduces Visceral Adiposity and Improves Metabolic Abnormalities in Subjects with Metabolic Syndrome or Type 2 Diabetes: Randomized Crossover Trials.
Peptide therapy for Type I diabetes: the immunological homunculus and the rationale for vaccination.
Polymorphism of HSP70 gene is not associated with type 1 (insulin-dependent) diabetes mellitus in Japanese.
Predominant immunoreactivity of Porphyromonas gingivalis heat shock protein in autoimmune diseases.
Protein kinase A-dependent translocation of Hsp90 alpha impairs endothelial nitric-oxide synthase activity in high glucose and diabetes.
Purification of recombinant human Hsp60: use of a GroEL-free preparation to assess autoimmunity in rheumatoid arthritis.
Restoring HSP70 Deficiencies Improves Glucose Tolerance in Diabetic Monkeys.
Sequence homologies between hsp60 and autoantigens.
T cell proliferative responses of type 1 diabetes patients and healthy individuals to human hsp60 and its peptides.
Th1 and Th2 cell responses of type 1 diabetes patients and healthy controls to human heat-shock protein 60 peptides AA437-460 and AA394-408.
Type 2 diabetes mellitus induces congenital heart defects in murine embryos by increasing oxidative stress, endoplasmic reticulum stress and apoptosis.
[The role of hsp60 and hsp70 kDa heat shock protein families in different types of diabetes mellitus]
Diabetes Mellitus, Type 1
A rapid method to study heat shock protein 70-2 gene polymorphism in insulin-dependent diabetes mellitus.
A role of Hsp60 in autoimmune diabetes: analysis in a transgenic model.
Analysis of serum Hsp90 as a potential biomarker of ? cell autoimmunity in type 1 diabetes.
Antibodies to heat shock protein 65 kD in type 1 diabetes mellitus.
Autoimmune diabetes induced by the beta-cell toxin STZ. Immunity to the 60-kDa heat shock protein and to insulin.
Characterization of human DNA topoisomerase II as an autoantigen recognized by patients with IDDM.
Citrullinated glucose-regulated protein 78 is an autoantigen in type 1 diabetes.
Deficient heat shock protein 70 response to stress in leukocytes at onset of type 1 diabetes.
Detection of autoantibodies to the pancreatic islet heat shock protein 60 in insulin-dependent diabetes mellitus.
Detection of heat shock protein in patients with insulin-dependent diabetes mellitus.
Diabetes mellitus in cystic fibrosis: genetic and immunological markers.
Effect of heat shock protein peptide DiaPep277 on beta-cell function in paediatric and adult patients with recent-onset diabetes mellitus type 1: two prospective, randomized, double-blind phase II trials.
Effect of intrathymic administration of mycobacterial heat shock protein 65 and peptide p277 on the development of diabetes in NOD mice: caution required in vaccination studies.
Enhanced immunogenicity of peptide P277 by heat shock protein HSP65 vector carrying tandem repeats of P277 to prevent type 1 diabetes in NOD mice.
Glucose regulated proteins 78 protects insulinoma cells (NIT-1) from death induced by streptozotocin, cytokines or cytotoxic T lymphocytes.
Heat shock protein 27 is associated with better nerve function and fewer signs of neuropathy.
Heat shock protein 60 elicits abnormal response in macrophages of diabetes-prone non-obese diabetic mice.
Heat shock protein 70 is necessary to improve mitochondrial bioenergetics and reverse diabetic sensory neuropathy following KU-32 therapy.
Heat Shock Protein HSP60 in Left Ventricular Cardiomyocytes of Hypertensive Rats with and without Insulin-Dependent Diabetes Mellitus.
Higher urine heat shock protein 70/creatinine ratio in type 1 diabetes mellitus.
Immune modulation induced by tuberculosis DNA vaccine protects non-obese diabetic mice from diabetes progression.
Immunomodulation with heat shock protein DiaPep277 to preserve beta cell function in type 1 diabetes - an update.
Induction and therapy of autoimmune diabetes in the non-obese diabetic (NOD/Lt) mouse by a 65-kDa heat shock protein.
Induction of diabetes in standard mice by immunization with the p277 peptide of a 60-kDa heat shock protein.
Inflammation-Induced Citrullinated Glucose-Regulated Protein 78 Elicits Immune Responses in Human Type 1 Diabetes.
Investigation of endoplasmic reticulum stress and sonic hedgehog pathway in diabetic liver injury in mice.
Molecular mimicry between varicella, measles virus and Hsp60 in type 1 diabetes associated HLA-DR3/DR4 molecules.
No independent association between HSP70 gene polymorphism and IDDM.
NOD mouse diabetes: the ubiquitous mouse hsp60 is a beta-cell target antigen of autoimmune T cells.
Oral administration of Lactococcus lactis-expressing heat shock protein 65 and tandemly repeated IA2P2 prevents type 1 diabetes in NOD mice.
Polymorphic analysis of the human MHC-linked heat shock protein 70 (HSP70-2) and HSP70-Hom genes in insulin-dependent diabetes mellitus (IDDM).
Production and purification of a recombinant human hsp60 epitope using the cellulose-binding domain in Escherichia coli.
Proinsulin and heat shock protein 90 as biomarkers of beta-cell stress in the early period after onset of type 1 diabetes.
Promotion of atherosclerosis in high cholesterol diet-fed rabbits by immunization with the P277 peptide.
Proteomic characterization of pancreatic islet {beta}-cells stimulated with pancreatic carcinoma cell conditioned medium.
Recognition of heat shock protein 60 epitopes in children with type 1 diabetes.
Secretory granule autoantigen in insulin-dependent diabetes mellitus is related to 62 kDa heat-shock protein (hsp60).
Sequence homology of the diabetes-associated autoantigen glutamate decarboxylase with coxsackie B4-2C protein and heat shock protein 60 mediates no molecular mimicry of autoantibodies.
T cell proliferative responses of type 1 diabetes patients and healthy individuals to human hsp60 and its peptides.
T cells and autoantibodies to human HSP70 in type 1 diabetes in children.
Targeted delivery of antigen to intestinal dendritic cells induces oral tolerance and prevents autoimmune diabetes in NOD mice.
The hsp60 peptide p277 arrests the autoimmune diabetes induced by the toxin streptozotocin.
The pathogenicity of islet-infiltrating lymphocytes in the non-obese diabetic (NOD) mouse.
Therapy with the hsp60 peptide DiaPep277 in C-peptide positive type 1 diabetes patients.
Transgenic Expression of Hsc70 in Pancreatic Islets Enhances Autoimmune Diabetes in Response to {beta} Cell Damage.
Treatment of autoimmune diabetes and insulitis in NOD mice with heat shock protein 60 peptide p277.
Treatment of new-onset type 1 diabetes with peptide DiaPep277 is safe and associated with preserved beta-cell function: extension of a randomized, double-blind, phase II trial.
Type 1 diabetes alters anti-hsp90 autoantibody isotype.
Vaccination of non-obese diabetic mice with a fragment of peptide P277 attenuates insulin-dependent diabetes mellitus.
[High-dose heat shock protein gp96 immunization prevents type 1 diabetes via inducing regulatory T cells].
[Improved efficacy of P277 fused to heat shock protein 65 of Mycobacterium tuberculosis against diabetes in nonobese diabetic mice]
[Intranasal vaccination with mycobacterial 65-kD heat-shock protein can prevent insulitis and diabetes in non-obese diabetic mice].
Diabetes Mellitus, Type 2
1267 HSP70-2 polymorphism as a risk factor for carotid plaque rupture and cerebral ischaemia in old type 2 diabetes-atherosclerotic patients.
Antibodies to heat-shock protein 65 and neopterin levels in patients with type 1 diabetes mellitus.
Association Between Promoter Polymorphisms of the GRP78 Gene and Risk of Type 2 Diabetes in a Chinese Han Population.
Association of extracellular heat shock protein 70 and insulin resistance in type 2 diabetes; independent of obesity and C-reactive protein.
Association of humoral immunity to human Hsp60 with the IL-6 gene polymorphism C-174G in patients with type 2 diabetes and controls.
Association of polymorphism in heat shock protein 70 genes with type 2 diabetes in Bangladeshi population.
Attenuation of exercise-induced heat shock protein 72 expression blunts improvements in whole-body insulin resistance in rats with type 2 diabetes.
Central Acting Hsp10 Regulates Mitochondrial Function, Fatty Acid Metabolism, and Insulin Sensitivity in the Hypothalamus.
Chaperone-Based Therapeutic Target Innovation: Heat Shock Protein 70 (HSP70) for Type 2 Diabetes Mellitus.
Circulating heat shock protein 27 as a novel marker of subclinical atherosclerosis in type 2 diabetes: a cross-sectional community-based study.
Decreased expression of endoplasmic reticulum chaperone GRP78 in liver of diabetic mice.
Decreased expression of heat shock protein 72 in skeletal muscle of patients with type 2 diabetes correlates with insulin resistance.
Decreased Thioredoxin-1 and Increased HSP90 Expression in Skeletal Muscle in Subjects with Type 2 Diabetes or Impaired Glucose Tolerance.
Detection of autoantibodies to the pancreatic islet heat shock protein 60 in insulin-dependent diabetes mellitus.
Detection of Hsp60 in saliva and serum from type 2 diabetic and non-diabetic control subjects.
Elevated levels of heat-shock protein 70 (HSP70) in the mononuclear cells of patients with non-insulin-dependent diabetes mellitus.
Exercise training improves basal blood glucose metabolism with no changes of cytosolic inhibitor B kinase or c-Jun N-terminal kinase activation in skeletal muscle of Otsuka Long-Evans Tokushima fatty rats.
Heat shock protein 70 and albuminuria in patients with type 2 diabetes: a matched case control study.
Heat Shock Protein 70 Gene Polymorphism in Egyptian Patients with Type 2 Diabetes Mellitus, with and without Nephropathy.
Heat shock protein studies in type 1 and type 2 diabetes and human islet cell culture.
Heat shock protein-70 and hypoxia inducible factor-1? in type 2 diabetes mellitus patients complicated with retinopathy.
Heat shock treatment with mild electrical stimulation safely reduced inflammatory markers in healthy male subjects.
HSP72 protects against obesity-induced insulin resistance.
Intramuscular heat shock protein 72 and heme oxygenase-1 mRNA are reduced in patients with type 2 diabetes: evidence that insulin resistance is associated with a disturbed antioxidant defense mechanism.
Is heat shock protein 60 associated with type 2 diabetes mellitus?
Leptin regulation of Hsp60 impacts hypothalamic insulin signaling.
Mild Electrical Stimulation with Heat Shock Reduces Visceral Adiposity and Improves Metabolic Abnormalities in Subjects with Metabolic Syndrome or Type 2 Diabetes: Randomized Crossover Trials.
Plasma heat shock protein response to euglycemia in type 2 diabetes.
Polymorphism of stress protein HSP70-2 gene in Tunisians: susceptibility implications in type 2 diabetes and obesity.
Predicted therapeutic targets for COVID-19 disease by inhibiting SARS-CoV-2 and its related receptors.
Predominant immunoreactivity of Porphyromonas gingivalis heat shock protein in autoimmune diseases.
Proteomic analysis of primary cultures of human adipose-derived stem cells: modulation by Adipogenesis.
Serum heat shock protein 70 and oxidized LDL in patients with type 2 diabetes: does sex matter?
The chaperone balance hypothesis: the importance of the extracellular to intracellular HSP70 ratio to inflammation-driven type 2 diabetes, the effect of exercise, and the implications for clinical management.
The dual behavior of heat shock protein 70 and asymmetric dimethylarginine in relation to serum CRP levels in type 2 diabetes.
The endoplasmic reticulum chaperone improves insulin resistance in type 2 diabetes.
The lost correlation between heat shock protein 70 (HSPA1A) and plasminogen activator inhibitor-1 in patients with type 2 diabetes and albuminuria.
Type 2 diabetes mellitus induces congenital heart defects in murine embryos by increasing oxidative stress, endoplasmic reticulum stress and apoptosis.
[Effects of curcumin on protein expression of glucose regulated protein 78 and caspase-12 of myocardial endoplasmic reticulum stress related factors in type 2 diabetes rats].
Diabetes, Gestational
Increased circulating heat shock protein 70 (HSPA1A) levels in gestational diabetes mellitus: a pilot study.
Diabetic Cardiomyopathies
Exercise modulates heat shock protein 27 activity in diabetic cardiomyopathy.
Heat shock protein 60 (HSP60) modulates adiponectin signaling by stabilizing adiponectin receptor.
Hsp10 and Hsp60 suppress ubiquitination of insulin-like growth factor-1 receptor and augment insulin-like growth factor-1 receptor signaling in cardiac muscle: implications on decreased myocardial protection in diabetic cardiomyopathy.
IGF-I is a matter of heart.
Insulin deficiency downregulated heat shock protein 60 and IGF-1 receptor signaling in diabetic myocardium.
Tanshinone IIA ameliorates diabetic cardiomyopathy by inhibiting Grp78 and CHOP expression in STZ-induced diabetes rats.
The carboxyl terminus of heat shock protein 70-interacting protein (CHIP) participates in high glucose-induced cardiac injury.
[The effect and mechanism of heat shock protein 47 on streptozotocin-induced diabetic cardiomyopathy].
Diabetic Foot
Heat Shock Protein 70 Gene Single Nucleotide Polymorphism and Diabetic Foot Ulcer. Is There Any Relationship?
Heat-shock protein 70 gene polymorphism is associated with the severity of diabetic foot ulcer and the outcome of surgical treatment.
Diabetic Ketoacidosis
Diabetic ketoacidosis increases extracellular levels of the major inducible 70-kDa heat shock protein.
Diabetic Nephropathies
Activin A and Cell-Surface GRP78 Are Novel Targetable RhoA Activators for Diabetic Kidney Disease.
Advanced glycation end products increase collagen-specific chaperone protein in mouse diabetic nephropathy.
Alpha-lipoic Acid modulates heat shock factor-1 expression in streptozotocin-induced diabetic rat kidney.
Association of A1538G and C2437T single nucleotide polymorphisms in heat shock protein-70 genes with diabetic nephropathy among South Indian population.
Cell surface expression of 78-kDa glucose-regulated protein (GRP78) mediates diabetic nephropathy.
Coexpression of collagens and collagen-binding heat shock protein 47 in human diabetic nephropathy and IgA nephropathy.
Heat shock protein expression in diabetic nephropathy.
Levels of circulating GRP78 and CHOP in endoplasmic reticulum stress pathways in Chinese type 2 diabetic kidney disease patients.
Stress proteins in glomerular epithelial cell injury.
[Role of heat shock protein 47 on experimental diabetic nephropathy of rats]
Diabetic Neuropathies
Induction of heat shock proteins may combat insulin resistance.
Serum heat shock protein 27 and diabetes complications in the EURODIAB prospective complications study: a novel circulating marker for diabetic neuropathy.
Diabetic Retinopathy
Catechin Weakens Diabetic Retinopathy by Inhibiting the Expression of NF-?B Signaling Pathway-Mediated Inflammatory Factors.
Elevated Activating Transcription Factor 4 and Glucose-Regulated 78 Kda Protein Levels Correlate with Inflammatory Cytokines in the Aqueous Humor and Vitreous of Proliferative Diabetic Retinopathy.
Heat shock protein-70 and hypoxia inducible factor-1? in type 2 diabetes mellitus patients complicated with retinopathy.
Diffuse Axonal Injury
The expression and changes of heat shock protein 70, MDA and haemorheology in rat cortex after diffuse axonal injury with secondary insults.
Digestive System Neoplasms
The Clinical Value of HSP60 in Digestive System Cancers: a Systematic Review and Meta-Analysis.
The role of ferroptosis in digestive system cancer.
Diphtheria
Heat shock proteins induce pores in membranes.
Host Cell Chaperones Hsp70/Hsp90 and Peptidyl-Prolyl Cis/Trans Isomerases Are Required for the Membrane Translocation of Bacterial ADP-Ribosylating Toxins.
Increased proteolysis of diphtheria toxin by human monocytes after heat shock: a subsidiary role for heat-shock protein 70 in antigen processing.
Potential of anti-Candida antibodies in immunoprophylaxis.
Protective antitumor immunity induced by tumor cell lysates conjugated with diphtheria toxin and adjuvant epitope in mouse breast tumor models.
The Hsp90 machinery facilitates the transport of diphtheria toxin into human cells.
Distal Myopathies
A knock-in/knock-out mouse model of HSPB8-associated distal hereditary motor neuropathy and myopathy reveals toxic gain-of-function of mutant Hspb8.
A novel heterozygous mutation in the C-terminal region of HSPB8 leads to limb-girdle rimmed vacuolar myopathy.
Distemper
Autophagy induction by the pathogen receptor NECTIN4 and sustained autophagy contribute to peste des petits ruminants virus infectivity.
Enhanced production of morbillivirus gene-specific RNAs following induction of the cellular stress response in stable persistent infection.
Down Syndrome
Beta-glucan's varying structure characteristics modulate survival and immune-related genes expression from Vibrio harveyi-infected Artemia franciscana in gnotobiotic conditions.
Heat-shock protein 70 levels in brain of patients with Down syndrome and Alzheimer's disease.
Upregulation of phosphorylated alphaB-crystallin in the brain of children and young adults with Down syndrome.
Drug-Related Side Effects and Adverse Reactions
Consequences of heat shock protein 72 (Hsp72) expression and activity on stress-induced apoptosis in CD30(+) NPM-ALK(+) anaplastic large-cell lymphomas.
Geranylgeranylacetone prevents acute liver damage after massive hepatectomy in rats through suppression of a CXC chemokine GRO1 and induction of heat shock proteins.
Heat Shock Protein 90 Inhibitors as Broad Spectrum Anti-infectives.
Dry Eye Syndromes
Interferon-?-Induced Unfolded Protein Response in Conjunctival Goblet Cells as a Cause of Mucin Deficiency in Sjögren Syndrome.
Proteomics Differentiate Between Thyroid-Associated Orbitopathy and Dry Eye Syndrome.
Therapeutic Potential of the Molecular Chaperone and Matrix Metalloproteinase Inhibitor Clusterin for Dry Eye.
Duodenal Ulcer
Polymorphisms in TNF and HSP-70 show a significant association with gastric cancer and duodenal ulcer.
Potential antigen candidates for subunit vaccine development against Helicobacter pylori infection.
Role of Heat-Shock Protein (HSP) 70-2 Genotype in Peptic Ulcer in Japanese Population.
Duodenogastric Reflux
Injury to the gastric mucosa and cellular dynamics in a rat model of duodenogastric reflux: the possible significance of gastrin induction and a heat shock protein.
Dysentery, Amebic
Hsp90 inhibitors as new leads to target parasitic diarrheal diseases.
Dyslexia
A novel role for DYX1C1, a chaperone protein for both Hsp70 and Hsp90, in breast cancer.
Dyslipidemias
1267 HSP70-2 polymorphism as a risk factor for carotid plaque rupture and cerebral ischaemia in old type 2 diabetes-atherosclerotic patients.
Dietary supplementation of brown seaweed (Sargassum latifolium) alleviates the environmental heat stress-induced toxicity in male Barki sheep (Ovis aries).
Effect of dyslipidemia on intima-media thickness of intra- and extracranial atherosclerosis by regulating the expression of hsp70 in rabbits.
Heat-shock protein 60 kDa and atherogenic dyslipidemia in patients with untreated mild periodontitis: a pilot study.
Dystonia
CSN complex controls the stability of selected synaptic proteins via a torsinA-dependent process.
Expression of TorsinA in a heterologous yeast system reveals interactions with lumenal domains of LINC and nuclear pore complex components.
Human TorsinA can function in the yeast cytosol as a molecular chaperone.
LULL1 Retargets TorsinA to the Nuclear Envelope Revealing an Activity that Is Impaired by the DYT1 Dystonia Mutation.
Miniature release events of glutamate from hippocampal neurons are influenced by the dystonia-associated protein torsinA.
Synaptic vesicle recycling is enhanced by torsinA that harbors the DYT1 dystonia mutation.
Dystonia Musculorum Deformans
Resolving the TorsinA Oligomerization Conundrum: The Glycan Hypothesis.
The BiP molecular chaperone plays multiple roles during the biogenesis of TorsinA, a AAA+ ATPase associated with the neurological disease Early-Onset Torsion Dystonia.
The early-onset torsion dystonia-associated protein, torsinA, displays molecular chaperone activity in vitro.
TorsinA participates in endoplasmic reticulum-associated degradation.
Dystonic Disorders
Structures of TorsinA and its disease-mutant complexed with an activator reveal the molecular basis for primary dystonia.
Echinococcosis
Molecular and immunological characterization of the C-terminal region of a new Echinococcus granulosus Heat Shock Protein 70.
Serological reactivity to heat shock protein 70 in patients with hydatid disease.
Ehrlichiosis
Aggregate-reactivation activity of the molecular chaperone ClpB from Ehrlichia chaffeensis.
Characterization of an immunoreactive protein from the agent of human granulocytic ehrlichiosis.
Heat shock protein 70 of the agent of human granulocytic ehrlichiosis binds to Borrelia burgdorferi antibodies.
Elephantiasis, Filarial
Biochemical characterization and evaluation of a Brugia malayi small heat shock protein as a vaccine against lymphatic filariasis.
Brugia malayi Wolbachia hsp60 IgG antibody and isotype reactivity in different clinical groups infected or exposed to human bancroftian lymphatic filariasis.
Characterization of an hsp70 gene from the human filarial parasite, Brugia malayi (Nematoda).
Heat shock cognate 70 is a prominent immunogen in Brugian filariasis.
Localization of paramyosin, myosin, and a heat shock protein 70 in larval and adult Brugia malayi.
Embolic Stroke
Correlation of diffusion MRI and heat shock protein in a rat embolic stroke model.
Encephalitis
Geldanamycin, a ligand of heat shock protein 90, inhibits herpes simplex virus type 2 replication both in vitro and in vivo.
HSP-70-Mediated Hyperbaric Oxygen Reduces Brain and Pulmonary Edema and Cognitive Deficits in Rats in a Simulated High-Altitude Exposure.
miR-16-1 expression, heat shock protein 70 and inflammatory reactions in astrocytes of mice with epilepsy induced by encephalitis B virus infection.
Oral administration of HSP-containing E. coli extract OM-89 has suppressive effects in autoimmunity. Regulation of autoimmune processes by modulating peripheral immunity towards hsp's?
Pharmacologic heat shock protein 70 induction confers cytoprotection against inflammation in gliovascular cells.
Encephalitis, Japanese
A KDEL Retrieval System for ER-Golgi Transport of Japanese Encephalitis Viral Particles.
Association of heat-shock protein 70 with lipid rafts is required for Japanese encephalitis virus infection in Huh7 cells.
Correction: Japanese encephalitis virus co-opts the ER-stress response protein GRP78 for viral infectivity.
Flavivirus Nonstructural Protein NS5 Dysregulates HSP90 to Broadly Inhibit JAK/STAT Signaling.
GRP78 Is an Important Host Factor for Japanese Encephalitis Virus Entry and Replication in Mammalian Cells.
Heat shock cognate protein 70 isoform D is required for clathrin-dependent endocytosis of Japanese encephalitis virus in C6/36cells.
Heat Shock Protein 70 Is Associated with Replicase Complex of Japanese Encephalitis Virus and Positively Regulates Viral Genome Replication.
Heat shock protein 70 on Neuro2a cells is a putative receptor for Japanese encephalitis virus.
Heat shock protein 90? in the Vero cell membrane binds Japanese encephalitis virus.
Hsp40 Protein DNAJB6 Interacts with Viral NS3 and Inhibits the Replication of the Japanese Encephalitis Virus.
HSP60 critically regulates endogenous IL-1? production in activated microglia by stimulating NLRP3 inflammasome pathway.
Identification of Heat Shock Protein 90 Beta in JEV-Induced Secretion Proteins.
Japanese encephalitis virus co-opts the ER-stress response protein GRP78 for viral infectivity.
Japanese encephalitis virus induces human neural stem/progenitor cell death by elevating GRP78, PHB and hnRNPC through ER stress.
Pathogenicity and virulence of Japanese encephalitis virus: Neuroinflammation and neuronal cell damage.
Encephalomyelitis
Amyloid fibrils composed of hexameric peptides attenuate neuroinflammation.
Brain-derived heat shock protein 70-Peptide complexes induce NK cell-dependent tolerance to experimental autoimmune encephalomyelitis.
EAE tolerance induction with Hsp70-peptide complexes depends on H60 and NKG2D activity.
Experimental autoimmune encephalomyelitis. Qualitative and semiquantitative differences in heat shock protein 60 expression in the central nervous system.
Heat shock protein 27 upregulation and phosphorylation in rat experimental autoimmune encephalomyelitis.
Heat shock protein 90: a pathophysiological factor and novel treatment target in autoimmune bullous skin diseases.
Heat shock proteins and experimental autoimmune encephalomyelitis (EAE): I. Immunization with a peptide of the myelin protein 2',3' cyclic nucleotide 3' phosphodiesterase that is cross-reactive with a heat shock protein alters the course of EAE.
Hsp70 regulates immune response in experimental autoimmune encephalomyelitis.
miR-155-3p Drives the Development of Autoimmune Demyelination by Regulation of Heat Shock Protein 40.
Role of hsp90 in systemic lupus erythematosus and its clinical relevance.
Subcellular localisation of Theiler's murine encephalomyelitis virus (TMEV) capsid subunit VP1 vis-á-vis host protein Hsp90.
The 70-kDa heat shock cognate protein (HSC70) is a major constituent of the central nervous system and is up-regulated only at the mRNA level in acute experimental autoimmune encephalomyelitis.
The heat-shock protein 90 inhibitor 17-allylamino-17-demethoxygeldanamycin suppresses glial inflammatory responses and ameliorates experimental autoimmune encephalomyelitis.
WLS/wntless is essential in controlling dendritic cell homeostasis via a WNT signaling-independent mechanism.
[Protective effects of heat shock preconditioning on the experimental autoimmune encephalomyelitis rats]
Encephalomyelitis, Autoimmune, Experimental
Amyloid fibrils composed of hexameric peptides attenuate neuroinflammation.
Brain-derived heat shock protein 70-Peptide complexes induce NK cell-dependent tolerance to experimental autoimmune encephalomyelitis.
Characterization of migration parameters on peripheral and central nervous system T cells following treatment of experimental allergic encephalomyelitis with CRYAB.
CRYAB modulates the activation of CD4+ T cells from relapsing-remitting multiple sclerosis patients.
EAE tolerance induction with Hsp70-peptide complexes depends on H60 and NKG2D activity.
Experimental autoimmune encephalomyelitis. Qualitative and semiquantitative differences in heat shock protein 60 expression in the central nervous system.
Heat shock protein 27 upregulation and phosphorylation in rat experimental autoimmune encephalomyelitis.
Heat shock proteins and experimental autoimmune encephalomyelitis (EAE): I. Immunization with a peptide of the myelin protein 2',3' cyclic nucleotide 3' phosphodiesterase that is cross-reactive with a heat shock protein alters the course of EAE.
Hsp70 regulates immune response in experimental autoimmune encephalomyelitis.
miR-155-3p Drives the Development of Autoimmune Demyelination by Regulation of Heat Shock Protein 40.
The 70-kDa heat shock cognate protein (HSC70) is a major constituent of the central nervous system and is up-regulated only at the mRNA level in acute experimental autoimmune encephalomyelitis.
The heat-shock protein 90 inhibitor 17-allylamino-17-demethoxygeldanamycin suppresses glial inflammatory responses and ameliorates experimental autoimmune encephalomyelitis.
Towards peptide immunotherapy in rheumatoid arthritis: competitor-modulator concept.
WLS/wntless is essential in controlling dendritic cell homeostasis via a WNT signaling-independent mechanism.
[Protective effects of heat shock preconditioning on the experimental autoimmune encephalomyelitis rats]
Encephalopathy, Bovine Spongiform
Stress response in the central nervous system of a transgenic mouse model of bovine spongiform encephalopathy.
Endocarditis
Cloning and sequencing of a part of the heat shock protein 65 gene (hsp65) of "Tropheryma whippelii" and its use for detection of "T. whippelii" in clinical specimens by PCR.
Enhanced levels of Staphylococcus aureus stress protein GroEL and DnaK homologs early in infection of human epithelial cells.
Global distribution of Bartonella infections in domestic bovine and characterization of Bartonella bovis strains using multi-locus sequence typing.
In the Search of Potential Serodiagnostic Proteins to Discriminate Between Acute and Chronic Q Fever in Humans. Some Promising Outcomes.
Prosthetic Valve Endocarditis with Bartonella washoensis in a Human European Patient and Its Detection in Red Squirrels (Sciurus vulgaris).
Streptococcus tigurinus is frequent among gtfR-negative Streptococcus oralis isolates and in the human oral cavity, but highly virulent strains are uncommon.
Endometrial Hyperplasia
Autophagy in the physiological endometrium and cancer.
Over-expression of heat shock proteins in carcinogenic endometrium.
[Expression and significance of heat shock protein 70, 90 in endometrial carcinomas]
Endometrial Neoplasms
A study of heat shock protein 27 in endometrial carcinoma.
AKT inhibition mitigates GRP78 (glucose-regulated protein) expression and contribution to chemoresistance in endometrial cancers.
Are IgG antibodies to heat shock proteins HSP27 and HSP60 useful markers in endometrial cancer and cervical cancer?
Autophagy in the physiological endometrium and cancer.
Bioluminescence Imaging to Monitor the Effects of the Hsp90 Inhibitor NVP-AUY922 on NF-?B Pathway in Endometrial Cancer.
Cell-free 27 kDa heat shock protein (hsp27) and hsp27-cytochrome c complexes in the cervix of women with ovarian or endometrial cancer.
Colocalization of estrogen and progesterone receptors with an estrogen-regulated heat shock protein in paraffin sections of human breast and endometrial cancer tissue.
Detection of the soluble heat shock protein 27 (hsp27) in human serum by an ELISA.
Endoplasmic reticulum stress is activated in endometrial adenocarcinoma.
Expression of heat shock proteins HSP70 and HSP90 in endometrial carcinomas. Correlation with clinicopathology, sex steroid receptor status, and p53 protein expression.
GRP78 induced by estrogen plays a role in the chemosensitivity of endometrial cancer.
GRP78 levels, regional fat distribution and endometrial cáncer.
GRP78 Mediates Cell Growth and Invasiveness in Endometrial Cancer.
High level of HSF1 associates with aggressive endometrial carcinoma and suggests potential for HSP90 inhibitors.
Identification of HSPA8 as a candidate biomarker for endometrial carcinoma by using iTRAQ-based proteomic analysis.
Immunological evidence for the identity between the hsp27 estrogen-regulated heat shock protein and the p29 estrogen receptor-associated protein in breast and endometrial cancer.
Intraperitoneal Fat through GRP78: A Risk Factor for Endometrial Cancer.
Life stress, negative mood states, and antibodies to heat shock protein 70 in endometrial cancer.
Over-expression of heat shock proteins in carcinogenic endometrium.
PGK1 and GRP78 overexpression correlates with clinical significance and poor prognosis in Chinese endometrial cancer patients.
PGK1 facilities cisplatin chemoresistance by triggering HSP90/ERK pathway mediated DNA repair and methylation in endometrial endometrioid adenocarcinoma.
Prognostic significance of heat shock proteins HSP70 and HSP90 in endometrial carcinomas.
Proteomic analysis in endometrial cancer and endometrial hyperplasia tissues by 2D-DIGE technique.
RNAi Screening of the Glucose-Regulated Chaperones in Cancer with Self-Assembled siRNA Nanostructures.
Silencing of heat shock protein 70 expression enhances radiotherapy efficacy and inhibits cell invasion in endometrial cancer cell line.
The endoplasmic reticulum stress marker, glucose-regulated protein-78 (GRP78) in visceral adipocytes predicts endometrial cancer progression and patient survival.
Utility and Mechanism of SHetA2 and Paclitaxel for Treatment of Endometrial Cancer.
[Expression and significance of heat shock protein 70, 90 in endometrial carcinomas]
[Expression of heat shock protein (HSP70) in normal endometrium and endometrial carcinomas]
[Heat shock proteins and malignancies of the female genital tract]
Endometriosis
An investigation of the effects of endometriosis on the proteome of human eutopic endometrium: a heterogeneous tissue with a complex disease.
Cell-mediated immunity to human and Escherichia coli 60-kDa heat shock protein in women: association with a history of spontaneous abortion and endometriosis.
Decreased expression of human heat shock protein 70 in the endometria and pathological lesions of women with adenomyosis and uterine myoma after GnRH agonist therapy.
Differential expression of genes in eutopic and ectopic endometrium from patients with ovarian endometriosis.
Distribution of heat shock proteins in eutopic and ectopic endometrium in endometriosis and adenomyosis.
Effect of GnRH agonist therapy on the expression of human heat shock protein 70 in eutopic and ectopic endometria of women with endometriosis.
Expression of heat shock protein 70 kDa in human endometrium of normal and infertile women.
Expression of the 60 kDa heat shock protein in peritoneal fluids from women with endometriosis: implications for endometriosis-associated infertility.
Increased production of tumor necrosis factor-alpha by peritoneal fluid mononuclear cells induced by 60-kDa heat shock protein in women with minimal to mild endometriosis.
Levels of oestrogen receptor, progesterone receptor and ?B-crystallin in eutopic endometrium in relation to pregnancy in women with endometriosis.
Measurable serum markers of oxidative stress response in women with endometriosis.
Proteolytic tailoring of the heat shock protein 70 and its implications in the pathogenesis of endometriosis.
Serologic responses of infertile women to the 60-kd chlamydial heat shock protein (hsp60).
Toll-like receptor 4-mediated growth of endometriosis by human heat-shock protein 70.
[Inhibition effect and mechanisms of quercetin on surgically induced endometriosis]
Endometritis
Heat shock protein HSP90 immunoexpression in equine endometrium during oestrus, dioestrus and anoestrus.
Endophthalmitis
alphaB-crystallin protects retinal tissue during Staphylococcus aureus-induced endophthalmitis.
Endotoxemia
A single endotoxin challenge induces delayed myocardial protection against infarcation.
Cardiomyocyte-Specific Deficiency of HSPB1 Worsens Cardiac Dysfunction by Activating NF?B-Mediated Leukocyte Recruitment After Myocardial Infarction.
Effect of sodium arsenite on iNOS expression and vascular hyporeactivity associated with cecal ligation and puncture in the rat.
Endothelial HSPA12B Exerts Protection Against Sepsis-Induced Severe Cardiomyopathy via Suppression of Adhesion Molecule Expression by miR-126.
Endotoxemia in the infant rats modulates HSP60 protein level in the pancreatic acinar cells.
Heat shock protein 70 confers cardiovascular protection during endotoxemia via inhibition of nuclear factor-kappaB activation and inducible nitric oxide synthase expression in the rostral ventrolateral medulla.
Heat shock protein suppresses the senescent lung cytokine response to acute endotoxemia.
In the rostral ventrolateral medulla, the 70-kDa heat shock protein (HSP70), but not HSP90, confers neuroprotection against fatal endotoxemia via augmentation of nitric-oxide synthase I (NOS I)/protein kinase G signaling pathway and inhibition of NOS II/peroxynitrite cascade.
Induction of heat shock protein 70 by zinc-bis-(DL-hydrogenaspartate) reduces cytokine liberation, apoptosis, and mortality rate in a rat model of LD100 endotoxemia.
Influence of heat shock protein 70 and metallothionein induction by zinc-bis-(DL-hydrogenaspartate) on the release of inflammatory mediators in a porcine model of recurrent endotoxemia.
Long-lasting effect of infant rats endotoxemia on heat shock protein 60 in the pancreatic acinar cells: involvement of toll-like receptor 4.
The influence of heat shock protein 70 induction on hemodynamic variables in a porcine model of recurrent endotoxemia.
Enteritis
Mouse colitis induced by Escherichia coli producing Yersinia enterocolitica 60-kilodalton heat-shock protein: light and electron microscope study.
Ependymoma
Ependymoma Pediatric Brain Tumor Protein Fingerprinting by Integrated Mass Spectrometry Platforms: A Pilot Investigation.
Nucleoporin TPR (translocated promoter region, nuclear basket protein) upregulation alters MTOR-HSF1 trails and suppresses autophagy induction in ependymoma.
Epidermolysis Bullosa Acquisita
Aberrant expression and secretion of heat shock protein 90 in patients with bullous pemphigoid.
Autoantibodies to human stress proteins. A survey of various rheumatic and other inflammatory diseases.
Heat shock protein 90 inhibition: A potential double- or triple-edged sword in the treatment of mucous membrane pemphigoid.
Heat shock protein 90 is required for ex vivo neutrophil-driven autoantibody-induced tissue damage in experimental epidermolysis bullosa acquisita.
Heat shock protein 90: a pathophysiological factor and novel treatment target in autoimmune bullous skin diseases.
Heat-shock protein 90 inhibition in autoimmunity to type VII collagen: evidence that nonmalignant plasma cells are not therapeutic targets.
Immunomodulatory effects of heat shock protein 90 inhibition on humoral immune responses.
Topically Applied Hsp90 Blocker 17AAG Inhibits Autoantibody-Mediated Blister-Inducing Cutaneous Inflammation.
Epilepsy
Alterations of GABA(A) and glutamate receptor subunits and heat shock protein in rat hippocampus following traumatic brain injury and in posttraumatic epilepsy.
Blood biomarkers predictive of epilepsy after an acute stroke event.
CDDO-Me Attenuates Astroglial Autophagy via Nrf2-, ERK1/2-SP1- and Src-CK2-PTEN-PI3K/AKT-Mediated Signaling Pathways in the Hippocampus of Chronic Epilepsy Rats.
Cognitive Function and Heat Shock Protein 70 in Children With Temporal Lobe Epilepsy.
Correlation between seizure intensity and stress protein expression after limbic epilepsy in the rat brain.
Elevated interictal serum HSP-70 levels as an indicator of neurodegeneration for chronic migraine.
Epilepsy: HSP90 inhibition suppresses seizures.
Heat shock protein 70 expression in epilepsy suggests stress rather than protection.
Heat shock proteins and neuroprotection.
Hippocampal expression of heat shock proteins in mesial temporal lobe epilepsy with psychiatric comorbidities and their relation to seizure outcome.
Hsp60 response in experimental and human temporal lobe epilepsy.
Hsp90 inhibitor HSP990 in very low dose upregulates EAAT2 and exerts potent antiepileptic activity.
Hsp90? inhibitors prevent GLT-1 degradation but have no beneficial efficacy on absence epilepsy.
Inhibition of Hsp70 Suppresses Neuronal Hyperexcitability and Attenuates Epilepsy by Enhancing A-Type Potassium Current.
miR-16-1 expression, heat shock protein 70 and inflammatory reactions in astrocytes of mice with epilepsy induced by encephalitis B virus infection.
Molecular alterations of the TLR4-signaling cascade in canine epilepsy.
Pharmacologic inhibition of Hsp90 to prevent GLT-1 degradation as an effective therapy for epilepsy.
Systematic identification of the HSP90 regulated proteome.
The neuroprotective potential of heat shock protein 70 (HSP70).
Epilepsy, Reflex
[Effects of thermal preconditioning on convulsive activity in rats with inheritable form of audiogenic epilepsy].
Epilepsy, Temporal Lobe
Cognitive Function and Heat Shock Protein 70 in Children With Temporal Lobe Epilepsy.
Hsp60 response in experimental and human temporal lobe epilepsy.
Hsp90 inhibitor HSP990 in very low dose upregulates EAAT2 and exerts potent antiepileptic activity.
Inhibition of Hsp70 Suppresses Neuronal Hyperexcitability and Attenuates Epilepsy by Enhancing A-Type Potassium Current.
Epiretinal Membrane
Heat Shock Protein 90 Involvement in the Development of Idiopathic Epiretinal Membranes.
Epstein-Barr Virus Infections
Epstein-Barr virus upregulates phosphorylated heat shock protein 27 kDa in carcinoma cells using the phosphoinositide 3-kinase/Akt pathway.
Heat shock protein 90 expression in Epstein-Barr virus-infected B cells promotes gammadelta T-cell proliferation in vitro.
Identification of tumor necrosis factor signaling-related proteins during Epstein-Barr virus-induced B cell transformation.
Erectile Dysfunction
Heat shock protein 9-mediated inflammation reaction in patients with chronic prostatitis with erectile dysfunction.
Erythema
IgM anti-phenolic glycolipid I and IgG anti-10-kDa heat shock protein antibodies in sera and immune complexes isolated from leprosy patients with or without erythema nodosum leprosum and contacts.
Non-invasive detection of local tissue responses to predict pressure ulcer development in mouse models.
Prevention of the ultraviolet effects on clinical and histopathological changes, as well as the heat shock protein-70 expression in mouse skin by topical application of algal UV-absorbing compounds.
Erythema Nodosum
IgM anti-phenolic glycolipid I and IgG anti-10-kDa heat shock protein antibodies in sera and immune complexes isolated from leprosy patients with or without erythema nodosum leprosum and contacts.
Esophageal Neoplasms
Antiproliferative effect of the HSP90 inhibitor NVP-AUY922 is determined by the expression of PTEN in esophageal cancer.
Changes in the localization of heat shock protein 72 correlated with development of thermotolerance in human esophageal cancer cell line.
Combination of SNX-2112 with 5-FU exhibits antagonistic effect in esophageal cancer cells.
Down-regulation of Hsp90 could change cell cycle distribution and increase drug sensitivity of tumor cells.
Esophageal cancer alters the expression of nuclear pore complex binding protein Hsc70 and eIF5A-1.
Exogenous H2S promotes cancer progression by activating JAK2/STAT3 signaling pathway in esophageal EC109 cells.
Heat shock protein 105 peptide vaccine could induce antitumor immune reactions in a phase I clinical trial.
Identification of HLA-A2 or HLA-A24-restricted CTL epitopes for potential HSP105-targeted immunotherapy in colorectal cancer.
Inhibition of heat shock protein 90 suppresses squamous carcinogenic progression in a mouse model of esophageal cancer.
Novel immunohistochemical monoclonal antibody against human glucose-regulated protein 78.
PKC? counteracts oxidative stress by regulating Hsc70 in an esophageal cancer cell line.
Prognostic significance of heat shock protein 110 expression and T lymphocyte infiltration in esophageal cancer.
Tumor Immune Systems in Esophageal Cancer with Special Reference to Heat-shock Protein 70 and Humoral Immunity.
[Screening of differentially expressed proteins from human esophageal cancer and esophageal tissues by two-dimensional difference gel electrophoresis and mass spectrometry]
Esophageal Squamous Cell Carcinoma
BIIB021, a novel Hsp90 inhibitor, sensitizes esophageal squamous cell carcinoma to radiation.
Clinical Significance of Monitoring Circulating Free DNA and Plasma Heat Shock Protein 90alpha in Patients with Esophageal Squamous Cell Carcinoma.
Clinical significance of serum dynamics of HSP90a level in esophageal squamous cell carcinoma patients treated with definitive chemoradiotherapy.
Correlation between clinicopathology and expression of heat shock protein 72 and glycoprotein 96 in human esophageal squamous cell carcinoma.
Expression of heat shock protein 70 in grossly resected esophageal squamous cell carcinoma.
Expression of heat-shock protein Hsp60 correlated with the apoptotic index and patient prognosis in human oesophageal squamous cell carcinoma.
Expression patterns of aurora kinase B, heat shock protein 47, and periostin in esophageal squamous cell carcinoma.
Heat shock protein family B member 1 facilitates ezrin activation to control cell migration in esophageal squamous cell carcinoma.
High Expression of GRP78 Promotes Invasion and Metastases in Patients with Esophageal Squamous Cell Carcinoma.
HSP90 Inhibitor Ganetespib (STA-9090) Inhibits Tumor Growth in c-Myc-Dependent Esophageal Squamous Cell Carcinoma.
MicroRNA-27a downregulates the expression of Hsp90 and enhances the radiosensitivity in esophageal squamous cell carcinoma.
Overexpression of 27-kDa heat shock protein relates to poor histological differentiation in human oesophageal squamous cell carcinoma.
Promoter methylation of heat shock protein B2 in human esophageal squamous cell carcinoma.
Proteomics-based identification of autoantibody against heat shock protein 70 as a diagnostic marker in esophageal squamous cell carcinoma.
Silence of HDAC6 suppressed esophageal squamous cell carcinoma proliferation and migration by disrupting chaperone function of HSP90.
SUMOylation of HSP27 regulates PKM2 to promote esophageal squamous cell carcinoma progression.
Suppression of tumor necrosis factor receptor-associated protein 1 expression induces inhibition of cell proliferation and tumor growth in human esophageal cancer cells.
The HSP90 inhibitor 17-N-allylamino-17-demethoxy geldanamycin (17-AAG) synergizes with cisplatin and induces apoptosis in cisplatin-resistant esophageal squamous cell carcinoma cell lines via the Akt/XIAP pathway.
[Expression and significance of heat shock proteins in esophageal squamous cell carcinoma]
Esophagitis
Analysis of mucosal stress response in acid-induced esophagitis in opossum.
Expression of heat shock protein 27 in the esophageal tissue of rats with reflux esophagitis.
Esophagitis, Peptic
Expression of heat shock protein 27 in the esophageal tissue of rats with reflux esophagitis.
Specific induction of a 72-kDa heat shock protein protects esophageal mucosa from reflux esophagitis.
Essential Hypertension
Expression of Heat Shock Protein 70 Gene and Its Correlation with Inflammatory Markers in Essential Hypertension.
Induction of heat shock protein 72 protects against organ damage in essential hypertension: A hypothesis.
The role of autoimmune reactivity induced by heat shock protein 70 in the pathogenesis of essential hypertension.
Esthesioneuroblastoma, Olfactory
Expression patterns of Trk-A, Trk-B, GRP78, and p75NRT in olfactory neuroblastoma.
Exanthema
Prediction of an Epitope-based Computational Vaccine Strategy for Gaining Concurrent Immunization Against the Venom Proteins of Australian Box Jellyfish.
Exfoliation Syndrome
Aqueous humor heat-shock protein 70, periostin, and irisin levels in patients with pseudoexfoliation syndrome.
Epigenetic silencing of heat shock protein 70 through DNA hypermethylation in pseudoexfoliation syndrome and glaucoma.
Eye Diseases
First-in-Human Phase I Study of an Oral HSP90 Inhibitor, TAS-116, in Patients with Advanced Solid Tumors.
Fallopian Tube Diseases
Serum interleukin-1?, interleukin-8 and anti-heat shock 60 Chlamydia trachomatis antibodies as markers of ectopic pregnancy.
Fanconi Anemia
Hsp90 and the Fanconi anemia pathway: a molecular link between protein quality control and the DNA damage response.
Hsp90 regulates the Fanconi anemia DNA damage response pathway.
Molecular chaperone GRP94 binds to the Fanconi anemia group C protein and regulates its intracellular expression.
Strong antitumor synergy between DNA crosslinking and HSP90 inhibition causes massive premitotic DNA fragmentation in ovarian cancer cells.
Fanconi Syndrome
Na+,K(+)-ATPase expression in maleic-acid-induced Fanconi syndrome in rats.
Fatigue Syndrome, Chronic
Differential heat shock protein responses to strenuous standardized exercise in chronic fatigue syndrome patients and matched healthy controls.
Fatty Liver
CXC chemokine receptor 3 promotes steatohepatitis in mice through mediating inflammatory cytokines, macrophages and autophagy.
GRP78 as a regulator of liver steatosis and cancer progression mediated by loss of the tumor suppressor PTEN.
Inhibition of HSP90? Improves Lipid Disorders by Promoting Mature SREBPs Degradation via the Ubiquitin-proteasome System.
Liver-specific loss of glucose-regulated protein 78 perturbs the unfolded protein response and exacerbates a spectrum of liver diseases in mice.
Pancreastatin inhibitor activates AMPK pathway via GRP78 and ameliorates dexamethasone induced fatty liver disease in C57BL/6 mice.
The ménage à trois of autophagy, lipid droplets and liver disease.
Fatty Liver, Alcoholic
Changes in tumor necrosis factor-?, heat shock protein 70, malondialdehyde, and superoxide dismutase in patients with different severities of alcoholic fatty liver disease: a prospective observational study.
Fetal Growth Retardation
Assessment of placental and maternal stress responses in patients with pregnancy related complications via monitoring of heat shock protein mRNA levels.
Decreased expression of phosphorylated placental heat shock protein 27 in human and ovine intrauterine growth restriction (IUGR).
Enhancement of heat shock protein 70 attenuates inducible nitric oxide synthase in preeclampsia complicated with fetal growth restriction.
Heat Shock Protein 70 Expression is Increased in the Liver of Neonatal Intrauterine Growth Retardation Piglets.
Heat shock protein 70 is upregulated in the intestine of intrauterine growth retardation piglets.
Heat shock proteins and heat shock protein-antibody complexes in placental tissues.
Impairment of cellular immunity is associated with overexpression of heat shock protein 70 in neonatal pigs with intrauterine growth retardation.
Fetal Hypoxia
Assessment of placental and maternal stress responses in patients with pregnancy related complications via monitoring of heat shock protein mRNA levels.
Fetal Membranes, Premature Rupture
Polymorphisms in the tumor necrosis factor-alpha gene at position -308 and the inducible 70 kd heat shock protein gene at position +1267 in multifetal pregnancies and preterm premature rupture of fetal membranes.
Fibroma
Expression of HSP90 in gastrointestinal stromal tumours and mesenchymal tumours.
Oral lichen planus: an immunohistochemical study of heat shock proteins (HSPs) and cytokeratins (CKs) and a unifying hypothesis of pathogenesis.
Fibromatosis, Gingival
Effect of transforming growth factor-beta1, interleukin-6, and interferon-gamma on the expression of type I collagen, heat shock protein 47, matrix metalloproteinase (MMP)-1 and MMP-2 by fibroblasts from normal gingiva and hereditary gingival fibromatosis.
Immunoexpression of ?2-integrin and Hsp47 in hereditary gingival fibromatosis and gingival fibromatosis-associated dental abnormalities.
Fibromyalgia
(220) Associations between heat shock protein and symptom burden in Fibromyalgia Syndrome (FMS).
Fibrosarcoma
A 2,5-Dihydroxybenzoic Acid-Gelatin Conjugate Inhibits the Basal and Hsp90-Stimulated Migration and Invasion of Tumor Cells.
Actinopyrone D, a new downregulator of the molecular chaperone GRP78 from Streptomyces sp.
Autoreactive and heat shock protein 60-recognizing CD4+ T-cells show antitumor activity against syngeneic fibrosarcoma.
Cell surface heparan sulfate proteoglycans are involved in the binding of Hsp90? and Hsp90? to the cell plasma membrane.
Cell surface heparan sulfate proteoglycans are involved in the extracellular Hsp90-stimulated migration and invasion of cancer cells.
Effect of heat shock protein 90 (Hsp90) on migration and invasion of human cancer cells in vitro.
Efrapeptin J, a new down-regulator of the molecular chaperone GRP78 from a marine Tolypocladium sp.
Expression of the 72-kD heat shock protein is induced by ultraviolet A radiation in a human fibrosarcoma cell line.
Extracellular roles for the molecular chaperone, hsp90.
Functional proteomic screens reveal an essential extracellular role for hsp90 alpha in cancer cell invasiveness.
HSP60 is transported through the secretory pathway of 3-MCA-induced fibrosarcoma tumour cells and undergoes N-glycosylation.
Induction of Hsp60 by Photofrin-mediated photodynamic therapy.
Induction of plasminogen activator inhibitor 1 biosynthesis by hyperthermia.
Involvement of peptide antigens in the cytotoxicity between 70-kDa heat shock cognate protein-like molecule and CD3+, CD4-, CD8-, TCR-alpha beta- killer T cells.
Novel GRP78 Molecular Chaperone Expression Down-regulators JBIR-04 and -05 Isolated from Streptomyces violaceoniger.
Prevention of TNF-induced necrotic cell death by rottlerin through a Nox1 NADPH oxidase.
Preventive and therapeutic effect of tumor derived heat shock protein, gp96, in an experimental prostate cancer model.
Prunustatin A, a novel GRP78 molecular chaperone down-regulator isolated from Streptomyces violaceoniger.
The Broad Stroke of Hsp90 Inhibitors: Painting over the RAF Inhibitor Paradox.
The characterization of exosomes from fibrosarcoma cell and the useful usage of Dynamic Light Scattering (DLS) for their evaluation.
The effect of vaccination with the lysate of heat-shocked tumor cells on nitric oxide production in BALB/c mice with fibrosarcoma tumor.
Use of the glucose starvation-inducible glucose-regulated protein 78 promoter in suicide gene therapy of murine fibrosarcoma.
Use of the stress-inducible grp78/BiP promoter in targeting high level gene expression in fibrosarcoma in vivo.
[The Role of Membrane-Bound Heat Shock Proteins Hsp90 in Migration of Tumor Cells in vitro and Involvement of Cell Surface Heparan Sulfate Proteoglycans in Protein Binding to Plasma Membrane].
Filariasis
Heat shock cognate 70 is a prominent immunogen in Brugian filariasis.
Sequencing of the complete gene coding for the GroEL of the Wolbachia of Dirofilaria immitis and expression and purification of the recombinant protein.
Flavivirus Infections
Flavivirus Nonstructural Protein NS5 Dysregulates HSP90 to Broadly Inhibit JAK/STAT Signaling.
Fluorosis, Dental
[Effect of fluoride on the expression of endoplasmic reticulum chaperone in ameloblast of rat incisor].
Follicular Cyst
Levels of heat shock protein transcripts in normal follicles and ovarian follicular cysts.
Foodborne Diseases
Glucose-regulated protein 75 in foodborne disease models induces renal tubular necrosis.
Foot Ulcer
Heat Shock Protein 70 Gene Single Nucleotide Polymorphism and Diabetic Foot Ulcer. Is There Any Relationship?
Heat-shock protein 70 gene polymorphism is associated with the severity of diabetic foot ulcer and the outcome of surgical treatment.
Foot-and-Mouth Disease
The Cellular Chaperone Heat Shock Protein 90 Is Required for Foot-and-Mouth Disease Virus Capsid Precursor Processing and Assembly of Capsid Pentamers.
Friedreich Ataxia
A role for astrocytes in cerebellar deficits in frataxin deficiency: Protection by insulin-like growth factor I.
GRP75 overexpression rescues frataxin deficiency and mitochondrial phenotypes in Friedreich Ataxia cellular models.
Frontotemporal Dementia
Potentiated Hsp104 variants suppress toxicity of diverse neurodegenerative disease-linked proteins.
Transgenic expression of inclusion body myopathy associated mutant p97/VCP causes weakness and ubiquitinated protein inclusions in mice.
VCP maintains lysosomal homeostasis and TFEB activity in differentiated skeletal muscle.
Frontotemporal Lobar Degeneration
Decrease of neuronal FKBP4/FKBP52 modulates perinuclear lysosomal positioning and MAPT/Tau behavior during MAPT/Tau-induced proteotoxic stress.
Phosphoproteomic Analysis Reveals Site-Specific Changes in GFAP and NDRG2 Phosphorylation in Frontotemporal Lobar Degeneration.
Fuchs' Endothelial Dystrophy
Unfolded protein response in fuchs endothelial corneal dystrophy: a unifying pathogenic pathway?
Gallbladder Neoplasms
Small molecule inhibitor screening identifified HSP90 inhibitor 17-AAG as potential therapeutic agent for gallbladder cancer.
Gastritis
An increased number of gamma/delta T-cells and gastric epithelial cell expression of the groEL stress-protein homologue in Helicobacter pylori-associated chronic gastritis of the antrum.
Autoantibodies to a specific peptide epitope of human Hsp60 (ATVLA) with homology to Helicobacter pylori HspB in H. pylori-infected patients.
Circulating antibodies to the 60-kD heat shock protein (hsp) family in patients with Helicobacter pylori infection.
Clarithromycin increases the release of heat shock protein B from Helicobacter pylori.
Combined Extracts of
Effect of bacterial flora on postimmunization gastritis following oral vaccination of mice with Helicobacter pylori heat shock protein 60.
Expression of heat shock protein 90 beta in human gastric cancer tissue and SGC7901/VCR of MDR-type gastric cancer cell line.
Helicobacter pylori heat shock protein 60 mediates interleukin-6 production by macrophages via a toll-like receptor (TLR)-2-, TLR-4-, and myeloid differentiation factor 88-independent mechanism.
Immune response in Helicobacter pylori-induced low-grade gastric-mucosa-associated lymphoid tissue (MALT) lymphoma.
Seropositivity to Helicobacter pylori heat shock protein 60 is strongly associated with intensity of chronic inflammation, particularly in antrum mucosa: an extension of an 18-year follow-up study of chronic gastritis in Saaremaa, Estonia.
Significance of expression of heat shock protein90alpha in human gastric cancer.
Suppressive effects of DNA vaccines encoding heat shock protein on Helicobacter pylori-induced gastritis in mice.
[Relationship between Pi-Wei damp-heat syndrome with expressions of nuclear factor-kappaBmRNA and heat shock protein 70 mRNA in patients with chronic gastritis]
Gastritis, Atrophic
Heat Shock Protein 27 Expression is Inversely Correlated with Atrophic Gastritis and Intraepithelial Neoplasia.
[Effect of Chinese drugs for strengthening Pi, harmonizing Wei, and dispersing blood stasis on the expression of gastric mucosal heat shock protein 70 in chronic atrophic gastritis patients].
Gastroesophageal Reflux
Use of oesophageal stress response proteins as potential biomarkers in the screening for Barrett's oesophagus.
Gastrointestinal Diseases
Diagnostic, clinicopathologic, therapeutic and prognostic value of Plasma Heat Shock Protein 90 levels in patients with advanced Gastrointestinal Carcinoma.
Gastrointestinal Neoplasms
A phase I study of multi-HLA-binding peptides derived from heat shock protein 70/glypican-3 and a novel combination adjuvant of hLAG-3Ig and Poly-ICLC for patients with metastatic gastrointestinal cancers: YNP01 trial.
Diagnostic, clinicopathologic, therapeutic and prognostic value of Plasma Heat Shock Protein 90 levels in patients with advanced Gastrointestinal Carcinoma.
Heat shock proteins are differentially expressed in human gastrointestinal cancers.
Heat-shock protein 90 (Hsp90) as a molecular target for therapy of gastrointestinal cancer.
Mortalin/glucose-regulated protein 75 promotes the cisplatin-resistance of gastric cancer via regulating anti-oxidation/apoptosis and metabolic reprogramming.
Gastrointestinal Stromal Tumors
A phase 1 study of the heat shock protein 90 inhibitor retaspimycin hydrochloride (IPI-504) in patients with gastrointestinal stromal tumors or soft tissue sarcomas.
A Phase 2 Study of the Hsp90 Inhibitor AUY922 as Treatment for Patients with Refractory Gastrointestinal Stromal Tumors.
An investigation into the potential use of serum Hsp70 as a novel tumour biomarker for Hsp90 inhibitors.
Dose-escalation study of a second-generation non-ansamycin HSP90 inhibitor, onalespib (AT13387), in combination with imatinib in patients with metastatic gastrointestinal stromal tumour.
Efficacy and safety of TAS-116, an oral inhibitor of heat shock protein 90, in patients with metastatic or unresectable gastrointestinal stromal tumour refractory to imatinib, sunitinib and regorafenib: a phase II, single-arm trial.
Expression of HSP90 in gastrointestinal stromal tumours and mesenchymal tumours.
Heat shock protein 90 inhibition in imatinib-resistant gastrointestinal stromal tumor.
Heat shock protein 90 overexpression independently predicts inferior disease-free survival with differential expression of the alpha and beta isoforms in gastrointestinal stromal tumors.
Heat Shock Proteins: A Potential Anticancer Target.
Inhibitors of deacetylases suppress oncogenic KIT signaling, acetylate HSP90, and induce apoptosis in gastrointestinal stromal tumors.
STI571 (Glivec) inhibits the interaction between c-KIT and heat shock protein 90 of the gastrointestinal stromal tumor cell line, GIST-T1.
The heat shock protein 90 inhibitor IPI-504 induces KIT degradation, tumor shrinkage and cell proliferation arrest in xenografts models of gastrointestinal stromal tumors.
The HSP90 Inhibitor, AT13387, Is Effective against Imatinib-Sensitive and -Resistant Gastrointestinal Stromal Tumor Models.
[2 + 2 + 2] Cyclotrimerization with Propargyl Halides as Copartners: Formal Total Synthesis of the Antitumor Hsp90 Inhibitor AT13387.
Gaucher Disease
Brain-penetrant heat shock protein amplifier arimoclomol enhances GCase activity in in vitro Gaucher disease models.
Histone deacetylase inhibitors increase glucocerebrosidase activity in Gaucher disease by modulation of molecular chaperones.
Mutant glucocerebrosidase in Gaucher disease recruits Hsp27 to the Hsp90 chaperone complex for proteasomal degradation.
Treatment perspectives for the lysosomal storage diseases.
Genetic Diseases, Inborn
Genomic structure of the human mitochondrial chaperonin genes: HSP60 and HSP10 are localised head to head on chromosome 2 separated by a bidirectional promoter.
Histone deacetylase inhibitors increase glucocerebrosidase activity in Gaucher disease by modulation of molecular chaperones.
HSP90 Shapes the Consequences of Human Genetic Variation.
Molecular chaperones: small heat shock proteins in the limelight.
Giant Cell Arteritis
Serum levels of antibodies to Chlamydia pneumoniae and human HSP60 in giant cell arteritis patients.
Giardiasis
Hsp90 inhibitors as new leads to target parasitic diarrheal diseases.
Gingival Diseases
PCR array analysis identified hyperproliferation but not autophagy or apoptosis in fibrous epulis.
Serum antibodies to Porphyromonas gingivalis chaperone HtpG predict health in periodontitis susceptible patients.
Gingivitis
IgG class, but not IgA or IgM, antibodies to peptides of the Porphyromonas gingivalis chaperone HtpG predict health in periodontitis using a fluorescent ELISA.
Salivary anti-hsp65 antibodies as a diagnostic marker for gingivitis and a possible link to atherosclerosis.
Serum antibodies to Porphyromonas gingivalis chaperone HtpG predict health in periodontitis susceptible patients.
Up-regulation of the endoplasmic reticulum stress-response in periodontal disease.
Glanders
Detection of the host immune response to Burkholderia mallei heat-shock proteins GroEL and DnaK in a glanders patient and infected mice.
Development of a microsphere-based immunoassay for the serological detection of glanders in equids.
Identification of a new diagnostic antigen for glanders using immunoproteome analysis.
Glaucoma
Amino acid regions 357-368 and 418-427 of Streptococcus pyogenes 60kDa heat shock protein are recognized by antibodies from glaucomatous patient sera.
Anti-Ro/SS-A positivity and heat shock protein antibodies in patients with normal-pressure glaucoma.
Antibodies to alpha B-crystallin, vimentin, and heat shock protein 70 in aqueous humor of patients with normal tension glaucoma and IgG antibody patterns against retinal antigen in aqueous humor.
Aqueous humor heat-shock protein 70, periostin, and irisin levels in patients with pseudoexfoliation syndrome.
Association between open-angle glaucoma and gene polymorphism for heat-shock protein 70-1.
Association of eNOS and HSP70 gene polymorphisms with glaucoma in Pakistani cohorts.
Changes in gene expression in experimental glaucoma and optic nerve transection: the equilibrium between protective and detrimental mechanisms.
Complex antibody profile changes in an experimental autoimmune glaucoma animal model.
Down-regulation of GRP78 in human glaucomatous trabecular meshwork cells.
Engineered superparamagnetic Mn(0.5)Zn(0.5)Fe(2)O(4) nanoparticles as a heat shock protein induction agent for ocular neuroprotection in glaucoma.
Epigenetic silencing of heat shock protein 70 through DNA hypermethylation in pseudoexfoliation syndrome and glaucoma.
Evaluation of heat shock protein (HSP-72) expression in retinal ganglion cells of rats with glaucoma.
Heat shock protein 72 protects retinal ganglion cells in rat model of acute glaucoma.
Histochemical Analysis of Glaucoma Caused by a Myocilin Mutation in a Human Donor Eye.
Induced autoimmunity to heat shock proteins elicits glaucomatous loss of retinal ganglion cell neurons via activated T-cell-derived fas-ligand.
Induction of heat shock protein 72 in RGCs of rat acute glaucoma model after heat stress or zinc administration.
Induction of heat shock protein 72 protects retinal ganglion cells in a rat glaucoma model.
Levels of antibodies against human heat shock protein (HSP) 60 in patients with glaucoma in Poland.
Retinal ganglion cell protection with geranylgeranylacetone, a heat shock protein inducer, in a rat glaucoma model.
S100 Alone Has the Same Destructive Effect on Retinal Ganglion Cells as in Combination with HSP 27 in an Autoimmune Glaucoma Model.
Sensitized heat shock protein 27 induces retinal ganglion cells apoptosis in rat glaucoma model.
Serum autoantibodies to heat shock proteins in glaucoma patients from Japan and the United States.
The expression of heat shock protein 27 in retinal ganglion and glial cells in a rat glaucoma model.
The Small Heat Shock Protein ?-Crystallin B Shows Neuroprotective Properties in a Glaucoma Animal Model.
[The expression of heat shock protein 27 in retinal ganglion cells in the rat glaucoma model.]
[The GG genotype of the HSPA1B gene is associated with increased risk of glaucoma in northern Iran].
Glaucoma, Angle-Closure
HSP70 expression before and after treatment and its clinical value in patients with acute angle-closure glaucoma.
Glaucoma, Open-Angle
Anti-Ro/SS-A positivity and heat shock protein antibodies in patients with normal-pressure glaucoma.
Association between open-angle glaucoma and gene polymorphism for heat-shock protein 70-1.
Association of eNOS and HSP70 gene polymorphisms with glaucoma in Pakistani cohorts.
BDNF and HSP gene polymorphisms and their influence on the progression of primary open-angle glaucoma in a Polish population.
Discovery of a Potent Grp94 Selective Inhibitor with Anti-Inflammatory Efficacy in a Mouse Model of Ulcerative Colitis.
Down-regulation of GRP78 in human glaucomatous trabecular meshwork cells.
Isoform-selective Hsp90 inhibition rescues model of hereditary open-angle glaucoma.
Glioblastoma
17AEP-GA, an HSP90 antagonist, is a potent inhibitor of glioblastoma cell proliferation, survival, migration and invasion.
A 2,5-Dihydroxybenzoic Acid-Gelatin Conjugate Inhibits the Basal and Hsp90-Stimulated Migration and Invasion of Tumor Cells.
A Brain-Penetrating Hsp90 Inhibitor NXD30001 Inhibits Glioblastoma as a Monotherapy or in Combination With Radiation.
A Novel Extracellular Hsp90 Mediated Co-Receptor Function for LRP1 Regulates EphA2 Dependent Glioblastoma Cell Invasion.
Acquired resistance to 17-allylamino-17-demethoxygeldanamycin (17-AAG, tanespimycin) in glioblastoma cells.
Aldehyde dehydrogenase and HSP90 co-localize in human glioblastoma biopsy cells.
Antibody Targeting GRP78 Enhances the Efficacy of Radiation Therapy in Human Glioblastoma and Non-Small Cell Lung Cancer Cell Lines and Tumor Models.
Association of elevated GRP78 expression with increased astrocytoma malignancy via Akt and ERK pathways.
ATF4 links ER stress with reticulophagy in glioblastoma cells.
Autologous Heat Shock Protein Peptide Vaccination for Newly Diagnosed Glioblastoma: Impact of Peripheral PD-L1 Expression on Response to Therapy.
Biomarker discovery: a proteomic approach for brain cancer profiling.
Biophysical evidence for differential gallated green tea catechins binding to membrane type-1 matrix metalloproteinase and its interactors.
Calreticulin, a Molecular Chaperone in the Endoplasmic Reticulum, Modulates Radiosensitivity of Human Glioblastoma U251MG Cells.
Celastrol targets proteostasis and acts synergistically with a heat-shock protein 90 inhibitor to kill human glioblastoma cells.
Cell surface GRP78 as a biomarker and target for suppressing glioma cells.
Cell surface heparan sulfate proteoglycans are involved in the binding of Hsp90? and Hsp90? to the cell plasma membrane.
Cell surface heparan sulfate proteoglycans are involved in the extracellular Hsp90-stimulated migration and invasion of cancer cells.
Cell-type variation in stress responses as a consequence of manipulating GRP78 expression in neuroectodermal cells.
Chaperonins in cancer: Expression, function, and migration in extracellular vesicles.
Characterizing Cell Stress and GRP78 in Glioma to Enhance Tumor Treatment.
CTL responses to HSP47 associated with the prolonged survival of patients with glioblastomas.
Cytoplasmic sequestration of the tumor suppressor p53 by a heat shock protein 70 family member, mortalin, in human colorectal adenocarcinoma cell lines.
Down-regulation of HSP60 Suppresses the Proliferation of Glioblastoma Cells via the ROS/AMPK/mTOR Pathway.
Dual PI3K- and mTOR-inhibitor PI-103 can either enhance or reduce the radiosensitizing effect of the Hsp90 inhibitor NVP-AUY922 in tumor cells: The role of drug-irradiation schedule.
Effect of heat shock protein 90 (Hsp90) on migration and invasion of human cancer cells in vitro.
Effective immunotherapy of rat glioblastoma with prolonged intratumoral delivery of exogenous heat shock protein Hsp70.
Efficacy of Onalespib, a Long-Acting Second-Generation HSP90 Inhibitor, as a Single Agent and in Combination with Temozolomide against Malignant Gliomas.
ER calcium discharge stimulates GDNF gene expression through MAPK-dependent and -independent pathways in rat C6 glioblastoma cells.
Ex vivo Hsp70-Activated NK Cells in Combination With PD-1 Inhibition Significantly Increase Overall Survival in Preclinical Models of Glioblastoma and Lung Cancer.
Expression and functional activity of heat shock proteins in human glioblastoma multiforme.
Expression of heme oxygenase isozyme mRNAs in the human brain and induction of heme oxygenase-1 by nitric oxide donors.
Expression of the small heat shock protein (hsp) 27 in human astrocytomas correlates with histologic grades and tumor growth fractions.
Geldanamycin-induced degradation of Chk1 is mediated by proteasome.
Global targeting of subcellular heat shock protein-90 networks for therapy of glioblastoma.
Glucose-regulated protein 78 substrate-binding domain alters its conformation upon EGCG inhibitor binding to nucleotide-binding domain: Molecular dynamics studies.
Green tea epigallocatechin gallate enhances therapeutic efficacy of temozolomide in orthotopic mouse glioblastoma models.
GRP78 determines glioblastoma sensitivity to UBA1 inhibition-induced UPR signaling and cell death.
GRP78 is overexpressed in glioblastomas and regulates glioma cell growth and apoptosis.
GRP78-targeted in-silico virtual screening of novel anticancer agents.
Heat Shock Protein 60 Regulation of the Mitochondrial Permeability Transition Pore in Tumor Cells.
Heat shock protein 72 expression allows permissive replication of oncolytic adenovirus dl1520 (ONYX-015) in rat glioblastoma cells.
Heat shock protein expression in human gliomas.
Heat Shock Protein Peptide Complex-96 (HSPPC-96) Vaccination for Recurrent Glioblastoma: A Phase II, Single Arm Trial.
Heat shock protein peptide complex-96 vaccination for newly diagnosed glioblastoma: a phase I, single-arm trial.
Heat shock protein vaccines against glioblastoma: from bench to bedside.
Heat shock proteins in glioblastomas.
Heat shock transcription factor, HSF, is activated by ultraviolet irradiation.
HSP27 knockdown produces synergistic induction of apoptosis by HSP90 and kinase inhibitors in glioblastoma multiforme.
Hsp90 inhibition by NVP-AUY922 and NVP-BEP800 decreases migration and invasion of irradiated normoxic and hypoxic tumor cell lines.
Hsp90 inhibition enhances PI-3 kinase inhibition and radiosensitivity in glioblastoma.
Hsp90 inhibitor NMS-E973 exerts the anticancer effect against glioblastoma via induction of PUMA-mediated apoptosis.
Immunoexpression patterns for Hypoxia-inducible Factor-1? and von Hippel-Lindau protein, in relation to Hsp90, of human brain tumors.
Increased radiosensitivity and radiothermosensitivity of human pancreatic MIA PaCa-2 and U251 glioblastoma cell lines treated with the novel Hsp90 inhibitor NVP-HSP990.
Induction of radiation resistance by a heat shock protein inhibitor, KNK437, in human glioblastoma cells.
Inhibition of glioma growth by flavokawain B is mediated through endoplasmic reticulum stress induced autophagy.
Inhibition of HSP90 as a Strategy to Radiosensitize Glioblastoma: Targeting the DNA Damage Response and Beyond.
Inhibition of Hsp90 function by ansamycins causes downregulation of cdc2 and cdc25c and G(2)/M arrest in glioblastoma cell lines.
Inhibition of nestin suppresses stem cell phenotype of glioblastomas through the alteration of post-translational modification of heat shock protein HSPA8/HSC71.
Interaction of Hsp90 with the nascent form of the mutant epidermal growth factor receptor EGFRvIII.
Irradiation facilitates the inhibitory effect of the heat shock protein 90 inhibitor NVP-BEP800 on the proliferation of malignant glioblastoma cells through attenuation of the upregulation of heat shock protein 70.
Low co-expression of epidermal growth factor receptor and its chaperone heat shock protein 90 is associated with worse prognosis in primary glioblastoma, IDH-wild-type.
Mechanistic evaluation of the novel HSP90 inhibitor NVP-AUY922 in adult and pediatric glioblastoma.
MEK-inhibitor PD184352 enhances the radiosensitizing effect of the Hsp90 inhibitor NVP-AUY922: the role of cell type and drug-irradiation schedule.
Membrane Hsp70-supported cell-to-cell connections via tunneling nanotubes revealed by live-cell STED nanoscopy.
Overexpression of cytosolic, plasma membrane bound and extracellular heat shock protein 70 (Hsp70) in primary glioblastomas.
Photo-immune therapy with liposomally formulated phospholipid-conjugated indocyanine green induces specific antitumor responses with heat shock protein-70 expression in a glioblastoma model.
Plasminogen kringle 5 induces apoptosis of brain microvessel endothelial cells: sensitization by radiation and requirement for GRP78 and LRP1.
Proteomic Analysis on Anti-Proliferative and Apoptosis Effects of Curcumin Analog, 1,5-bis(4-Hydroxy-3-Methyoxyphenyl)-1,4-Pentadiene-3-One-Treated Human Glioblastoma and Neuroblastoma Cells.
Quantitative proteomic analysis shows differentially expressed HSPB1 in glioblastoma as a discriminating short from long survival factor and NOVA1 as a differentiation factor between low-grade astrocytoma and oligodendroglioma.
Retinoic acid-induced apoptotic pathway in T-cell lymphoma: Identification of four groups of genes with differential biological functions.
STAT3 and mutp53 Engage a Positive Feedback Loop Involving HSP90 and the Mevalonate Pathway.
Stimulation of Electroporation-Induced Inward Currents in Glioblastoma Cell Lines by the Heat Shock Protein Inhibitor AUY922.
Suppression of heat-induced HSF activation by CDDP in human glioblastoma cells.
T cell receptor repertoire as a prognosis marker for heat shock protein peptide complex-96 vaccine trial against newly diagnosed glioblastoma.
Targeting the unfolded protein response in glioblastoma cells with the fusion protein EGF-SubA.
The novel Hsp90 inhibitor NXD30001 induces tumor regression in a genetically engineered mouse model of glioblastoma multiforme.
The platelet-derived growth factor receptor alpha is destabilized by geldanamycins in cancer cells.
The protein kinase inhibitor, H-7, suppresses heat induced activation of heat shock transcription factor 1.
The small-molecule kinase inhibitor D11 counteracts 17-AAG-mediated up-regulation of HSP70 in brain cancer cells.
The unfolded protein response regulator GRP78/BiP as a novel target for increasing chemosensitivity in malignant gliomas.
Transactivation of the epidermal growth factor receptor by heat shock protein 90 via Toll-like receptor 4 contributes to the migration of glioblastoma cells.
UBE2T promotes glioblastoma invasion and migration via stabilizing GRP78 and regulating EMT.
Vorinostat suppresses hypoxia signaling by modulating nuclear translocation of hypoxia inducible factor 1 alpha.
[The Role of Membrane-Bound Heat Shock Proteins Hsp90 in Migration of Tumor Cells in vitro and Involvement of Cell Surface Heparan Sulfate Proteoglycans in Protein Binding to Plasma Membrane].
Glioma
70-kDa heat shock protein coated magnetic nanocarriers as a nanovaccine for induction of anti-tumor immune response in experimental glioma.
A carcinogenic trigger to study the function of tumor suppressor genes in Schmidtea mediterranea.
A High-Throughput Screen Identifies 2,9-Diazaspiro[5.5]Undecanes as Inducers of the Endoplasmic Reticulum Stress Response with Cytotoxic Activity in 3D Glioma Cell Models.
A novel therapeutic strategy for the treatment of glioma, combining chemical and molecular targeting of hsp90a.
Abrogation of mitogen-activated protein kinase and Akt signaling by vandetanib synergistically potentiates histone deacetylase inhibitor-induced apoptosis in human glioma cells.
Acidosis acts through HSP90 in a PHD/VHL-independent manner to promote HIF function and stem cell maintenance in glioma.
All-stage precisional glioma targeted therapy enabled by a well-designed D-peptide.
Alpha2 adrenoreceptor agonist regulates protein kinase C-induced heat shock protein 27 phosphorylation in C6 glioma cells.
Association between small heat shock protein B11 and the prognostic value of MGMT promoter methylation in patients with high-grade glioma.
Association of elevated GRP78 expression with increased astrocytoma malignancy via Akt and ERK pathways.
Augmentation of MHC class I antigen presentation via heat shock protein expression by hyperthermia.
Bcl2L12-mediated inhibition of effector caspase-3 and caspase-7 via distinct mechanisms in glioblastoma.
Can The Lack of HSP90alpha Protein in Brain Normal Tissue and Cell Lines, Rationalise it as a Possible Therapeutic Target for Gliomas?
Cell surface GRP78 as a biomarker and target for suppressing glioma cells.
Cell surface GRP78 regulates BACE2 via lysosome-dependent manner to maintain mesenchymal phenotype of glioma stem cells.
Characterization of promoter elements mediating ethanol regulation of hsc70 gene transcription.
Characterizing Cell Stress and GRP78 in Glioma to Enhance Tumor Treatment.
Cooperative inhibitory effect of ZD1839 (Iressa) in combination with 17-AAG on glioma cell growth.
Could the Anti-Chaperone VER155008 Replace Temozolomide for Glioma Treatment.
Deletion of the SPARC acidic domain or EGF-like module reduces SPARC-induced migration and signaling through p38 MAPK/HSP27 in glioma.
Different constitutive heat shock protein 70 expression during proliferation and differentiation of rat C6 glioma cells.
Differential display PCR reveals novel targets for the mood-stabilizing drug valproate including the molecular chaperone GRP78.
Differential effects of cysteamine on heat shock protein induction and cytoplasmic granulation in astrocytes and glioma cells.
Disruption of the EF-2 kinase/Hsp90 protein complex: a possible mechanism to inhibit glioblastoma by geldanamycin.
Effect of heat shock on intracellular calcium mobilization in neuroblastoma x glioma hybrid cells.
Effects of alcohol on gene expression in neural cells.
Effects of haloperidol and risperidone on the expression of heat shock protein 70 in MK-801-treated rat C6 glioma cells.
Efficacy of Onalespib, a Long-Acting Second-Generation HSP90 Inhibitor, as a Single Agent and in Combination with Temozolomide against Malignant Gliomas.
Efficacy of the HSP90 inhibitor 17-AAG in human glioma cell lines and tumorigenic glioma stem cells.
Endoplasmic reticulum chaperone prolyl 4-hydroxylase, beta polypeptide (P4HB) promotes malignant phenotypes in glioma via MAPK signaling.
Endoplasmic reticulum stress upregulates the chondroitin sulfate level which thus prevents neurite extension in C6 glioma cells and primary cultured astrocytes.
Enhanced cytotoxic effect of radiation and temozolomide in malignant glioma cells: targeting PI3K-AKT-mTOR signaling, HSP90 and histone deacetylases.
Enhanced radiosensitization of human glioma cells by combining inhibition of poly(ADP-ribose) polymerase with inhibition of heat shock protein 90.
Ethanol-responsive genes in neural cells include the 78-kilodalton glucose-regulated protein (GRP78) and 94-kilodalton glucose-regulated protein (GRP94) molecular chaperones.
Exogenous H2S promotes cancer progression by activating JAK2/STAT3 signaling pathway in esophageal EC109 cells.
Expression analysis of mortalin, a unique member of the Hsp70 family of proteins, in rat tissues.
Expression and functional activity of heat shock proteins in human glioblastoma multiforme.
Expression of heat shock proteins in brain tumors.
Glioma progression through the prism of heat shock protein mediated extracellular matrix remodeling and epithelial to mesenchymal transition.
Glioma: What is the role of c-Myc, hsp90 and telomerase?
GRP78 compartmentalized redistribution in Pb-treated glia: role of GRP78 in lead-induced oxidative stress.
GRP78 enabled micelle-based glioma targeted drug delivery.
GRP78 is overexpressed in glioblastomas and regulates glioma cell growth and apoptosis.
GRP78 overexpression as an unfavorable outcome in glioma patients.
GRP78 suppresses lipid peroxidation and promotes cellular antioxidant levels in glial cells following hydrogen peroxide exposure.
GRP78/BiP modulation of GRP78/BiP in altering sensitivity to chemotherapy.
Heat Shock Cognate Protein 70 Enhanced Integrin ?1 Mediated Invasion in Cancer Cells.
Heat Shock Protein 47 Promotes Glioma Angiogenesis.
Heat shock protein 47 regulated by miR-29a to enhance glioma tumor growth and invasion.
Heat shock protein 70 expression induces antitumor immunity during intracellular hyperthermia using magnetite nanoparticles.
Heat shock protein 70-binding protein 1 is highly expressed in high-grade gliomas, interacts with multiple heat shock protein 70 family members, and specifically binds brain tumor cell surfaces.
Heat shock protein 90alpha recruits FLIPS to the death-inducing signaling complex and contributes to TRAIL resistance in human glioma.
Heat shock protein expression in human gliomas.
Heat shock protein induction by certain chemical stressors is correlated with their cytotoxicity, lipophilicity and protein-denaturing capacity.
Heat Shock Protein Inhibitor 17-Allyamino-17-Demethoxygeldanamycin, a Potent Inductor of Apoptosis in Human Glioma Tumor Cell Lines, Is a Weak Substrate for ABCB1 and ABCG2 Transporters.
Heat shock protein synthesis is affected by intracellular pH: inhibition by monensin-induced alkalosis in C6 rat glioma cells.
Hsc70 Interacts with ?4GalT5 to Regulate the Growth of Gliomas.
Identification of amino acid appended acridines as potential leads to anti-cancer drugs.
Identification of Novel Interaction Partners of AIF Protein on the Outer Mitochondrial Membrane.
Image-guided control of transgene expression based on local hyperthermia.
Immunoexpression patterns for Hypoxia-inducible Factor-1? and von Hippel-Lindau protein, in relation to Hsp90, of human brain tumors.
Immunotherapy with heat shock protein 96 to treat gliomas.
Implication of reactive oxygen species, ERK1/2, and p38MAPK in sodium salicylate-induced heat shock protein 72 expression in C6 glioma cells.
Induction of 78 kD glucose-regulated protein (GRP78) expression and redox-regulated transcription factor activity by lead and mercury in C6 rat glioma cells.
Induction of heat shock protein 72 in C6 glioma cells by methyl jasmonate through ROS-dependent heat shock factor 1 activation.
Inhibition of 90-kD heat shock protein potentiates the cytotoxicity of chemotherapeutic agents in human glioma cells.
Inhibition of glioma growth by minocycline is mediated through endoplasmic reticulum stress-induced apoptosis and autophagic cell death.
Inhibition of Heat Shock Protein Response Enhances PS-341-Mediated Glioma Cell Death.
Interaction of ethanol with inducers of glucose-regulated stress proteins. Ethanol potentiates inducers of grp78 transcription.
Interplay between TRAP1 and sirtuin-3 modulates mitochondrial respiration and oxidative stress to maintain stemness of glioma stem cells.
Ionizing radiation improves glioma-specific targeting of superparamagnetic iron oxide nanoparticles conjugated with cmHsp70.1 monoclonal antibodies (SPION-cmHsp70.1).
Lead targets GRP78, a molecular chaperone, in C6 rat glioma cells.
Luteolin alleviates cognitive impairment in Alzheimer's disease mouse model via inhibiting endoplasmic reticulum stress-dependent neuroinflammation.
Mechanisms of neuronal adaptation to ethanol. Ethanol induces Hsc70 gene transcription in NG108-15 neuroblastoma x glioma cells.
Modulation of the arsenite-induced expression of stress proteins by reducing agents.
Novel Functional Association of Serine Palmitoyltransferase Subunit 1-A Peptide in Sphingolipid Metabolism with Cytochrome P4501A1 Transactivation and Proliferative Capacity of the Human Glioma LN18 Brain Tumor Cell Line.
Novel HSP90 inhibitor NVP-HSP990 targets cell cycle regulators to ablate Olig2-positive glioma tumor initiating cells.
Nuclear translocation of stress protein Hsc70 during S phase in rat C6 glioma cells.
Overexpression of GRP78 protects glial cells from endoplasmic reticulum stress.
Overexpression of Hsc70 promotes proliferation, migration, and invasion of human glioma cells.
Overexpression of ST6GalNAcV, a ganglioside-specific alpha2,6-sialyltransferase, inhibits glioma growth in vivo.
Participation of the chaperone Hsc70 in the trafficking and functional expression of ASIC2 in glioma cells.
Pharmacogenomic approach reveals a role for the x(c)- cystine/glutamate antiporter in growth and celastrol resistance of glioma cell lines.
Phosphorylation status of heat shock protein 27 regulates the interleukin-1?-induced interleukin-6 synthesis in C6 glioma cells.
Potential biomarkers of childhood brain tumor identified by proteomics of cerebrospinal fluid from extraventricular drainage (EVD).
Profiling Hsp90 differential expression and the molecular effects of the Hsp90 inhibitor IPI-504 in high-grade glioma models.
Retraction: Novel HSP90 inhibitor NVP-HSP990 targets cell-cycle regulators to ablate Olig 2-positive glioma tumor-initiating cells.
Secretory prostate apoptosis response (Par)-4 sensitizes multicellular spheroids (MCS) of glioblastoma multiforme cells to tamoxifen-induced cell death.
Small Heat Shock Protein ?B-Crystallin Controls Shape and Adhesion of Glioma and Myoblast Cells in the Absence of Stress.
Stress chaperone GRP78/BiP confers chemoresistance to tumor-associated endothelial cells.
Sulindac sulfide inhibits sarcoendoplasmic reticulum Ca2+ ATPase, induces endoplasmic reticulum stress response, and exerts toxicity in glioma cells: relevant similarities to and important differences from celecoxib.
Suppression of glial nitric oxide synthase induction by heat shock: effects on proteolytic degradation of IkappaB-alpha.
Synergistic interaction between 17-AAG and phosphatidylinositol 3-kinase inhibition in human malignant glioma cells.
Targeted nanoparticles that deliver a sustained, specific release of Paclitaxel to irradiated tumors.
Targeted therapies for malignant glioma: progress and potential.
Targeting GRP78 as a Basis for Enhanced Glioma Cells Killing by anti-TfR antibody.
Targeting HSP90 in malignant gliomas: onalespib as a potential therapeutic.
Targeting of endoplasmic reticulum (ER) stress in gliomas.
Targeting the unfolded protein response in glioblastoma cells with the fusion protein EGF-SubA.
The Effects of Venlafaxine and Dexamethasone on the Expression of HSP70 in Rat C6 Glioma Cells.
The geldanamycin analogue 17-allylamino-17-demethoxygeldanamycin inhibits the growth of GL261 glioma cells in vitro and in vivo.
The heat shock protein antagonist 17-AAG potentiates the activity of enzastaurin against malignant human glioma cells.
The modulation of protein kinase A and heat shock protein 70 is involved in the reversible increase of blood-brain tumor barrier permeability induced by papaverine.
The novel phloroglucinol derivative BFP induces apoptosis of glioma cancer through reactive oxygen species and endoplasmic reticulum stress pathways.
The unfolded protein response regulator GRP78/BiP as a novel target for increasing chemosensitivity in malignant gliomas.
Tumor targeting using magnetic nanoparticle Hsp70 conjugate in a model of C6 glioma.
Withania somnifera Suppresses Tumor Growth of Intracranial Allograft of Glioma Cells.
[Biodistribution of the recombinant heat shock protein rhHsp70 in intracranial C6 glioma models in Wistar rats and subcutaneos B16/F10 melanoma in C57BL/6 mice].
[Effect of cryotherapy and 5-fluorouracil on apoptosis of G422 glioma cells]
Gliosarcoma
Concerted actions of multiple transcription elements confer differential transactivation of HSP90 isoforms in geldanamycin-treated 9L rat gliosarcoma cells.
Control mechanisms of differential translation of Hsp90 isoforms in 9L rat gliosarcoma cells.
Differential expression of Hsp90 isoforms in geldanamycin-treated 9L cells.
Glomerulonephritis
Collagen-binding heat shock protein (HSP) 47 expression in anti-thymocyte serum (ATS)-induced glomerulonephritis.
Evaluation of antibodies against human HSP60 in patients with MPO-ANCA associated glomerulonephritis: a cohort study.
Heat shock protein 60 is released in immune-mediated glomerulonephritis and aggravates disease: in vivo evidence for an immunologic danger signal.
Heat shock protein 70 and anti-heat shock protein 70 antibodies in patients with chronic glomerulonephritis.
Heat shock protein 90 and NFkB levels in serum and urine in patients with chronic glomerulonephritis.
Heavy Chain Fibrillary Glomerulonephritis: A Case Report.
Lupus-specific kidney deposits of HSP90 are associated with altered IgG idiotypic interactions of anti-HSP90 autoantibodies.
Sequence homologies between hsp60 and autoantigens.
Toxoplasma gondii infection inhibits the development of lupus-like syndrome in autoimmune (New Zealand Black x New Zealand White) F1 mice.
[Investigation of 70-kDa heat shock protein in the serum and urine of patients with chronic glomerulonephritis].
Glomerulonephritis, IGA
A unique molecular chaperone Cosmc required for activity of the mammalian core 1 beta 3-galactosyltransferase.
Astragalus membranaceus up-regulate Cosmc expression and reverse IgA dys-glycosylation in IgA nephropathy.
Coexpression of collagens and collagen-binding heat shock protein 47 in human diabetic nephropathy and IgA nephropathy.
External suppression causes the low expression of the Cosmc gene in IgA nephropathy.
MicroRNA?196b targets COSMC in pediatric IgA nephropathy.
Mycophenolic acid reverses IgA1 aberrant glycosylation through up-regulating Cosmc expression in IgA nephropathy.
Renal tubular expression of Toll-like receptor 4 in cyclosporine nephrotoxicity.
Small bowel T cells, HLA class II antigen DR, and GroEL stress protein in IgA nephropathy.
Glucose Intolerance
Adiponectin reduces ER stress-induced apoptosis through PPAR? transcriptional regulation of ATF2 in mouse adipose.
Autoantibodies to pancreatic hsp60 precede the development of glucose intolerance in patients with cystic fibrosis.
Autoimmunity to HSP60 during diet induced obesity in mice.
Decreased Thioredoxin-1 and Increased HSP90 Expression in Skeletal Muscle in Subjects with Type 2 Diabetes or Impaired Glucose Tolerance.
Effects of vitamin D and resveratrol on metabolic associated markers in liver and adipose tissue from SAMP8 mice.
Exercise training with dietary counselling increases mitochondrial chaperone expression in middle-aged subjects with impaired glucose tolerance.
GRP78 overproduction in pancreatic beta cells protects against high-fat-diet-induced diabetes in mice.
HSP72 is a Mitochondrial Stress Sensor Critical for Parkin Action, Oxidative Metabolism, and Insulin Sensitivity in Skeletal Muscle.
Impaired Oxidative Metabolism and Inflammation are Associated with Insulin Resistance in ER{alpha} Deficient Mice.
Reduced nuclear protein 1 expression improves insulin sensitivity and protects against diet-induced glucose intolerance through up-regulation of heat shock protein 70.
Goiter
Immunomorphological Pattern of Molecular Chaperones in Normal and Pathological Thyroid Tissues and Circulating Exosomes: Potential Use in Clinics.
Gout
HSP60 Regulates Monosodium Urate Crystal-Induced Inflammation by Activating the TLR4-NF-?B-MyD88 Signaling Pathway and Disrupting Mitochondrial Function.
Graft vs Host Disease
Analysis of in vivo immunosuppressive and in vitro interaction with constitutive heat shock protein 70 activity of LF08-0299 (Tresperimus) and analogues.
Combined PI3K/Akt and Hsp90 targeting synergistically suppresses essential functions of alloreactive T cells and increases Tregs.
Elevated level of HSPA1L mRNA correlates with graft-versus-host disease.
Heat shock protein 70: correlation of expression with degree of graft-versus-host response and clinical graft-versus-host disease.
Hsp90 inhibition ameliorates CD4(+) T cell-mediated acute Graft versus Host disease in mice.
Hsp90 inhibition destabilizes Ezh2 protein in alloreactive T cells and reduces graft-versus-host disease in mice.
Selective depletion of alloreactive T cells by targeted therapy of heat shock protein 90: a novel strategy for control of graft-versus-host disease.
The HSP90 inhibitor, 17AAG, protects the intestinal stem cell niche and inhibits graft versus host disease development.
Gram-Negative Bacterial Infections
Crosstalk Between Nuclear Glucose-Regulated Protein 78 and Tumor Protein 53 Contributes to the Lipopolysaccharide Aggravated Apoptosis of Endoplasmic Reticulum Stress-Responsive Porcine Intestinal Epithelial Cells.
Granuloma
Dual-targeting GroEL/ES chaperonin and protein tyrosine phosphatase B (PtpB) inhibitors: A polypharmacology strategy for treating Mycobacterium tuberculosis infections.
Identification of Mycobacterium marinum 65 kD heat shock protein gene by polymerase chain reaction restriction analysis from lesions of swimming pool granuloma.
Involvement of heat shock protein 47 in Schistosoma japonicum-induced hepatic fibrosis in mice.
[Histological and immunohistochemical structure of pulmonary tuberculotic granulomas in untreated cases and cases treated with antitubercular drugs]
Graves Disease
Heat shock protein 70 (HSP70) and complement C4 genotypes in patients with hyperthyroid Graves' disease.
Heat shock protein 70 polymorphisms in Chinese patients with Graves' disease.
Induction in vitro of 72-kD heat shock protein in a continuous culture of rat thyroid cells, FRTL5.
Interferon gamma and iodide increase the inducibility of the 72 kD heat shock protein in cultured human thyroid epithelial cells.
Graves Ophthalmopathy
Human histocompatibility leukocyte antigen-DR and heat shock protein-70 expression in eye muscle tissue in thyroid-associated ophthalmopathy.
Guillain-Barre Syndrome
Serum antibody level against GroEL type heat-shock protein of Campylobacter jejuni in patients with Guillain-Barré syndrome.
Haemophilus Infections
Cross-reactive antigens shared by Pseudomonas aeruginosa, Helicobacter pylori, Campylobacter jejuni, and Haemophilus influenzae may cause false-positive titers of antibody to H. pylori.
Hamman-Rich Syndrome
Serum heat shock protein 47 levels are elevated in acute interstitial pneumonia.
Head and Neck Neoplasms
Association between hsp60 messenger-RNA levels and Cisplatin resistance in human head and neck-cancer cell-lines.
Carboxy-terminus Hsc70 interacting protein exerts a tumor inhibition function in head and neck cancer.
Expression of ?B-crystallin and its potential anti-apoptotic role in oral verrucous carcinoma.
Grp78 as a therapeutic target for refractory head-neck cancer with CD24(-)CD44(+) stemness phenotype.
HSP27 regulates viability and migration of cancer cell lines following irradiation.
HSP40 co-chaperone protein Tid1 suppresses metastasis of head and neck cancer by inhibiting Galectin-7-TCF3-MMP9 axis signaling.
HSP90 inhibition sensitizes head and neck cancer to platin-based chemoradiotherapy by modulation of the DNA damage response resulting in chromosomal fragmentation.
Inducible promoters for gene therapy of head and neck cancer: an in vitro study.
Interaction between HSP60 and {beta}-catenin promotes metastasis.
Molecular mechanisms of anti-tumor properties of P276-00 in head and neck squamous cell carcinoma.
Overcoming Limitations of Cisplatin Therapy by Additional Treatment With the HSP90 Inhibitor Onalespib.
The Endogenous GRP78 Interactome in Human Head and Neck Cancers: A Deterministic Role of Cell Surface GRP78 in Cancer Stemness.
The Hsp90 inhibitor 17-(allylamino)-17-demethoxygeldanamycin increases cisplatin antitumor activity by inducing p53-mediated apoptosis in head and neck cancer.
Wild-type EGFR Is Stabilized by Direct Interaction with HSP90 in Cancer Cells and Tumors.
Head Injuries, Closed
Histone deacetylase inhibitor ITF2357 is neuroprotective, improves functional recovery, and induces glial apoptosis following experimental traumatic brain injury.
Hearing Loss
Anti-inflammatory and Oto-Protective Effect of the Small Heat Shock Protein Alpha B-Crystallin (HspB5) in Experimental Pneumococcal Meningitis.
Attenuation of progressive hearing loss in a model of age-related hearing loss by a heat shock protein inducer, geranylgeranylacetone.
Autoimmune sensorineural hearing loss: is it still a clinical diagnosis?
Failure of elevated heat shock protein 70 antibodies to alter cochlear function in mice.
Polymorphisms of heat shock protein 70 genes (HSPA1A, HSPA1B and HSPA1L) and susceptibility of noise-induced hearing loss in a Chinese population: A case-control study.
Targeted delivery of geranylgeranylacetone to mitochondria by triphenylphosphonium modified nanoparticles: a promising strategy to prevent aminoglycoside-induced hearing loss.
The association of heat shock protein genetic polymorphisms with age-related hearing impairment in Taiwan.
Upregulation of HSP60 expression in the postnatal rat cochlea and rats with drug-induced hearing loss.
[Hearing loss -- can heat shock protein 70 be cited as prognostic marker?]
[To the question of genetic predisposition to the development of professional sensorineural hearing loss].
Hearing Loss, Noise-Induced
Association between polymorphisms of heat-shock protein 70 genes and noise-induced hearing loss: A meta-analysis.
Association of polymorphisms in heat shock protein 70 genes with the susceptibility to noise-induced hearing loss: A meta-analysis.
Association of Polymorphisms of Heat Shock Protein 70 with Susceptibility to Noise-Induced Hearing Loss in the Taiwanese Population.
Correction: Association between polymorphisms of heat-shock protein 70 genes and noise-induced hearing loss: A meta-analysis.
Correction: Association of polymorphisms in heat shock protein 70 genes with the susceptibility to noise-induced hearing loss: A meta-analysis.
Polymorphisms of heat shock protein 70 genes (HSPA1A, HSPA1B and HSPA1L) and susceptibility of noise-induced hearing loss in a Chinese population: A case-control study.
[Association between single nucleotide polymorphismsin human heat shock protein 70 gene and susceptibility to noise-induced hearing loss].
Hearing Loss, Sensorineural
Antibodies to HSP-70 in normal donors and autoimmune hearing loss patients.
Antibody reactivity to heat shock protein 70 and inner ear-specific proteins in patients with idiopathic sensorineural hearing loss.
Circulating Immune Complexes and Heat Shock Protein 70 in the Sera of Patients with Sudden Sensorineural Hearing Loss.
Evidence linking the 68 kilodalton antigen identified in progressive sensorineural hearing loss patient sera with heat shock protein 70.
Heat Shock Protein 70 Gene Polymorphisms in Sudden Sensorineural Hearing Loss.
Recognition of a dominant epitope in bovine heat-shock protein 70 in inner ear disease.
Serum antibodies to heat shock protein 70 in sensorineural hearing loss.
Serum heat shock protein 70 and its correlation with clinical characteristics in patients with sudden sensorineural hearing loss.
[Detection of humoral immune response to inner ear proteins in patients with sensorineural hearing loss]
Hearing Loss, Sudden
Evaluation of anti-hsp70 antibody screening in sudden deafness.
Heart Arrest
Prediction of an Epitope-based Computational Vaccine Strategy for Gaining Concurrent Immunization Against the Venom Proteins of Australian Box Jellyfish.
Heart Defects, Congenital
Heat shock protein 70-1 gene expression in pediatric heart surgery using blood cardioplegia.
Heat shock protein 72 expression in the right ventricle of patients undergoing congenital cardiac surgery.
No variation in Hsp70 mRNA level during cardiac surgery in pediatric patients evaluated by semiquantitative RT-PCR.
Right ventricle of patients undergoing congenital cardiac surgery differentially expresses haem oxygenase-1 and heat shock protein 70 genes.
The extracellular stress response to pediatric cardiopulmonary bypass.
[Expression of the heat shock protein-70 in the myocardial cells of cyanosis congenital heart diseases]
Heart Diseases
Autoimmune diseases and Helicobacter pylori infection.
Bartonella strains from ground squirrels are identical to Bartonella washoensis isolated from a human patient.
Circulating heat shock proteins and inflammatory markers in patients with idiopathic left ventricular dysfunction: their relationships with myocardial and microvascular impairment.
Elevated antibody levels against Chlamydia pneumoniae, human HSP60 and mycobacterial HSP65 are independent risk factors in myocardial infarction and ischaemic heart disease.
Helicobacter pylori and cardiovascular complications: a mechanism based review on role of Helicobacter pylori in cardiovascular diseases.
Hold me tight: Role of the heat shock protein family of chaperones in cardiac disease.
Keep your heart in shape: molecular chaperone networks for treating heart disease.
Progression of the role of CRYAB in signaling pathways and cancers.
Proteome dynamics and proteome function of cardiac 19S proteasomes.
The stress response: implications for the clinical development of hsp90 inhibitors.
Transforming growth factor-?-activated kinase 1 enhances H2O2-induced apoptosis independently of reactive oxygen species in cardiomyocytes.
Heart Failure
Akt1 expression and activity at different stages in experimental heart failure.
Aspirin Enhances the Protection of Hsp90 from Heat-Stressed Injury in Cardiac Microvascular Endothelial Cells Through PI3K-Akt and PKM2 Pathways.
Changes in Expressions of HSP27, HSP70, and Soluble Glycoprotein in Heart Failure Rats Complicated with Pulmonary Edema and Correlations with Cardiopulmonary Functions.
Changes in Hsp60 level of the failing heart following acute myocardial infarction and the effect of long-term treatment with trandolapril.
Deletion of heat shock protein 60 in adult mouse cardiomyocytes perturbs mitochondrial protein homeostasis and causes heart failure.
Effects of Hsp90 inhibitor on the RIP1-RIP3-MLKL pathway during the development of heart failure in mice.
Elevated circulating levels of heat shock protein 70 are related to systemic inflammatory reaction through monocyte Toll signal in patients with heart failure after acute myocardial infarction.
Extracellular Heat Shock Protein 60, Cardiac Myocytes, and Apoptosis.
Functional proteomic analysis of experimental autoimmune myocarditis-induced chronic heart failure in the rat.
H11 Kinase/Heat Shock Protein 22 Deletion Impairs Both Nuclear and Mitochondrial Functions of STAT3 and Accelerates the Transition Into Heart Failure on Cardiac Overload.
Heat shock protein 27 acts as a predictor of prognosis in chronic heart failure patients.
Heat shock protein 27 acts as a predictor of prognosis in chronic heart failure patients: Methodological issues.
Heat Shock Protein 60 in Cardiovascular Physiology and Diseases.
Heat shock protein 70 acts as a potential biomarker for early diagnosis of heart failure.
Heat shock protein 70 in patients with chronic heart failure: relation to disease severity and survival.
HSP60 in heart failure: abnormal distribution and role in cardiac myocyte apoptosis.
Hsp90 and its co-chaperone, Sgt1, as autoantigens in dilated cardiomyopathy.
Hsp90 Inhibitor Attenuates the Development of Pathophysiological Cardiac Fibrosis in Mouse Hypertrophy via Suppression of the Calcineurin-NFAT and c-Raf-Erk Pathways.
Induction of heat shock protein 72 in the failing heart is attenuated after an exposure to heat shock.
Interaction of serum 70-kDa heat shock protein levels and HspA1B (+1267) gene polymorphism with disease severity in patients with chronic heart failure.
Metolazone upregulates mitochondrial chaperones and extends lifespan in Caenorhabditis elegans.
Molecular chaperone, HSP60, and cytochrome P450 2E1 co-expression in dilated cardiomyopathy.
Neonatal Death and Heart Failure in Mouse with Transgenic HSP60 Expression.
PARM-1 is an endoplasmic reticulum molecule involved in endoplasmic reticulum stress-induced apoptosis in rat cardiac myocytes.
Proteomic Analysis Reveals Significant Alternations of Cardiac Small Heat Shock Protein Expression in Congestive Heart Failure.
Proteomic analysis reveals significant elevation of heat shock protein 70 in patients with chronic heart failure due to arrhythmogenic right ventricular cardiomyopathy.
Refined purification of large amounts of Rat cvHsp/HspB7 and partial biological characterization in vitro.
Regulation of heat shock protein 60 and 72 expression in the failing heart.
Regulation of kinase cascade activation and heat shock protein expression by poly(ADP-ribose) polymerase inhibition in doxorubicin-induced heart failure.
Right heart failure chronically stimulates heat shock protein 72 in heart and liver but not in other tissues.
Serum Heat Shock Protein 60 in Acute Heart Failure: A New Biomarker?
Soluble Glycoprotein 130 and Heat Shock Protein 27 as Novel Candidate Biomarkers of Chronic Heart Failure with Preserved Ejection Fraction.
Targeting Extracellular Heat Shock Protein 70 Ameliorates Doxorubicin-Induced Heart Failure Through Resolution of Toll-Like Receptor 2-Mediated Myocardial Inflammation.
Tissue-specific small heat shock protein 20 activation is not associated with traditional autophagy markers in Ossabaw swine with cardio-metabolic heart failure.
Upregulation of autophagy genes and the unfolded protein response in human heart failure.
[Antibodies to Hsp60 in newborn babies, to whom during the intervention for critical inborn heart failure, autologous cord blood was transfused, in early and late postoperative period].
[Useful tests to assess the clinical usefulness of new prognostic markers: the example of heart failure].
Heart Failure, Diastolic
Upregulation of GRP78 and caspase-12 in diastolic failing heart.
Heart Failure, Systolic
Cardiac signaling genes exhibit unexpected sequence diversity in sporadic cardiomyopathy, revealing HSPB7 polymorphisms associated with disease.
Heart Septal Defects, Atrial
Expression of proto-oncogenes, genes for muscle specific isoforms and heat shock protein (HSP) -70 gene in hypertrophied cardiac muscles from patients with atrial septal defect or tetralogy of Fallot.
Heart Septal Defects, Ventricular
Type 2 diabetes mellitus induces congenital heart defects in murine embryos by increasing oxidative stress, endoplasmic reticulum stress and apoptosis.
Heart Valve Diseases
Anti-Heat Shock Protein 27 Titers and Oxidative Stress Levels are Elevated in Patients With Valvular Heart Disease.
HELLP Syndrome
Elevated serum 70 kDa heat shock protein level reflects tissue damage and disease severity in the syndrome of hemolysis, elevated liver enzymes, and low platelet count.
Placenta derived factors involved in the pathogenesis of the liver in the syndrome of haemolysis, elevated liver enzymes and low platelets (HELLP): A review.
Hemangioma
Inhibition of heat shock protein 90 exerts an antitumour effect in angiosarcoma: involvement of the vascular endothelial growth factor signalling pathway.
Hemangiosarcoma
HSP90 inhibition in angiosarcoma.
Inhibition of heat shock protein 90 exerts an antitumour effect in angiosarcoma: involvement of the vascular endothelial growth factor signalling pathway.
Hematologic Diseases
Mitochondrial Hspa9/Mortalin regulates erythroid differentiation via iron-sulfur cluster assembly.
Hematologic Neoplasms
17-DMAG disrupted the autophagy flux leading to the apoptosis of acute lymphoblastic leukemia cells by inducing heat shock cognate protein 70.
Antimyeloma activity of heat shock protein-90 inhibition.
BIIB021, an Hsp90 inhibitor: A promising therapeutic strategy for blood malignancies (Review).
CPUY201112, a novel synthetic small-molecule compound and inhibitor of heat shock protein Hsp90, induces p53-mediated apoptosis in MCF-7 cells.
Heat shock factor 1 confers resistance to Hsp90 inhibitors through p62/SQSTM1 expression and promotion of autophagic flux.
Heat shock protein 90 and role of its chemical inhibitors in treatment of hematologic malignancies.
Heat Shock Proteins: A Potential Anticancer Target.
Hsp90 inhibitors promote p53-dependent apoptosis through PUMA and Bax.
Inducible knockout of GRP78/BiP in the hematopoietic system suppresses Pten-null leukemogenesis and AKT oncogenic signaling.
Phase I trial of the HSP90 inhibitor PF-04929113 (SNX5422) in adult patients with recurrent, refractory hematologic malignancies.
Preclinical evaluation of the Hsp90 inhibitor SNX-5422 in ibrutinib resistant CLL.
The anti-myeloma activity of a novel purine scaffold HSP90 inhibitor PU-H71 is via inhibition of both HSP90A and HSP90B1.
The Hsp32 inhibitors SMA-ZnPP and PEG-ZnPP exert major growth-inhibitory effects on D34(+)/CD38(+) and CD34(+)/CD38(-) AML progenitor cells.
The HSP90 inhibitor ganetespib: A potential effective agent for Acute Myeloid Leukemia in combination with cytarabine.
Hemochromatosis
Inflammation, genetics, and ischemic heart disease: focus on the major histocompatibility complex (MHC) genes.
Platelet-derived ?2M regulates monocyte inflammatory responses.
Hemorrhagic Fever, Crimean
Heat Shock Protein 70 family members interact with Crimean-Congo hemorrhagic fever virus and Hazara virus nucleocapsid proteins and perform a functional role in the nairovirus replication cycle.
Hemorrhagic Fever, Ebola
Ebola virus infection induces autoimmunity against dsDNA and HSP60.
Hemorrhagic Septicemia, Viral
VER-155008 induced Hsp70 proteins expression in fish cell cultures while impeding replication of two RNA viruses.
Hemorrhagic Stroke
[Protective and antiedema effect of heat shock protein hsp70 studied in vitro on hemorrhagic stroke model in nervous tissue].
Hepatitis
Autoimmunity in chronic active Helicobacter hepatitis of mice. Serum antibodies and expression of heat shock protein 70 in liver.
Evaluating post-transcriptional regulatory elements for enhancing transient gene expression levels in CHO K1 and HEK293 cells.
Evidence that peroxisome proliferator-activated receptor alpha is complexed with the 90-kDa heat shock protein and the hepatitis virus B X-associated protein 2.
Heat shock protein 60 inhibits Th1-mediated hepatitis model via innate regulation of Th1/Th2 transcription factors and cytokines.
Mitochondrial HSP70, HSP40, and HSP60 bind to the 3' untranslated region of the Murine hepatitis virus genome.
Sequence homologies between hsp60 and autoantigens.
Telomerase repeat amplification protocol (TRAP) activity upon recombinant expression and purification of human telomerase in a bacterial system.
Hepatitis A
Apolipoprotein J, a glucose-upregulated molecular chaperone, stabilizes core and NS5A to promote infectious hepatitis C virus virion production.
Use of urinary biomarkers of renal ischemia in a lamb preclinical left ventricular assist device model.
Viral contamination of shellfish: evaluation of methods and analysis of bacteriophages and human viruses.
Hepatitis B
A novel virus-like particle based on hepatitis B core antigen and substrate-binding domain of bacterial molecular chaperone DnaK.
A tetratricopeptide repeat half-site in the aryl hydrocarbon receptor is important for DNA binding and trans-activation potential.
Antisense oligodeoxynucleotides targeted against molecular chaperonin Hsp60 block human hepatitis B virus replication.
Aryl hydrocarbon (Ah) receptor levels are selectively modulated by hsp90-associated immunophilin homolog XAP2.
Binding site analysis of human HBV pol for molecular chaperonin, hsp60.
CCDC88A/GIV promotes HBV replication and progeny secretion via enhancing endosomal trafficking and blocking autophagic degradation.
Chaperone action in the posttranslational topological reorientation of the hepatitis B virus large envelope protein: Implications for translocational regulation.
Characterization of the AhR-hsp90-XAP2 core complex and the role of the immunophilin-related protein XAP2 in AhR stabilization.
Characterization of the phosphorylation status of the hepatitis B virus X-associated protein 2.
Complex Formation between Heat Shock Protein 72 and Hepatitis B Virus X Protein in Hepatocellular Carcinoma Tissues.
Complex formation between heat shock protein 72 and hepatitis B virus X protein in hepatocellular carcinoma tissues.
Concomitant cellular expression of heat shock regulated genes of hepatitis B virus surface antigen and of human growth hormone by a NIH-3T3 cell line.
Defining the role for XAP2 in stabilization of the dioxin receptor.
Design and Synthesis of Oxymatrine Analogues Overcoming Drug Resistance in Hepatitis B Virus through Targeting Host Heat Stress Cognate 70.
Divergent roles of hepatitis B virus X-associated protein 2 (XAP2) in human versus mouse Ah receptor complexes.
Efficient Hsp90-independent in vitro activation by Hsc70 and Hsp40 of duck hepatitis B virus reverse transcriptase, an assumed Hsp90 client protein.
Endogenous hepatic expression of the hepatitis B virus X-associated protein 2 is adequate for maximal association with aryl hydrocarbon receptor-90-kDa heat shock protein complexes.
Evidence that peroxisome proliferator-activated receptor alpha is complexed with the 90-kDa heat shock protein and the hepatitis virus B X-associated protein 2.
Expression of heat shock proteins (HSP27, HSP60, HSP70, HSP90, GRP78, GRP94) in hepatitis B virus-related hepatocellular carcinomas and dysplastic nodules.
Functional role of Hsp60 as a positive regulator of human viral infection progression.
Functional roles of GRP78 in hepatitis B virus infectivity and antigen secretion.
Generation of murine CTL by a hepatitis B virus-specific peptide and evaluation of the adjuvant effect of heat shock protein glycoprotein 96 and its terminal fragments.
Glucose-Regulated Protein 78 Is an Intracellular Antiviral Factor against Hepatitis B Virus.
HBx protein of hepatitis B virus (HBV) can form complex with mitochondrial HSP60 and HSP70.
Heat shock protein 70 and heat shock protein 90 synergistically increase hepatitis B viral capsid assembly.
Heat shock protein 90-independent activation of truncated hepadnavirus reverse transcriptase.
Heat shock proteins stimulate APOBEC-3-mediated cytidine deamination in the hepatitis B virus.
Hepadnavirus assembly and reverse transcription require a multi-component chaperone complex which is incorporated into nucleocapsids.
Hepatitis B virus replication could enhance regulatory T cell activity by producing soluble heat shock protein 60 from hepatocytes.
Hepatitis B virus X protein upregulates HSP90alpha expression via activation of c-Myc in human hepatocarcinoma cell line, HepG2.
Hsp90 is required for the activity of a hepatitis B virus reverse transcriptase.
Hsp90 makes the human HBV Pol competent for in vitro priming rather than maintaining the human HBV Pol/pregenomic RNA complex.
Human hepatitis B virus polymerase interacts with the molecular chaperonin Hsp60.
In vitro reconstitution of a functional duck hepatitis B virus reverse transcriptase: posttranslational activation by Hsp90.
In vitro reconstitution of functional hepadnavirus reverse transcriptase with cellular chaperone proteins.
Increased expression of Gp96 by HBx-induced NF-?B activation feedback enhances hepatitis B virus production.
Induction of apurinic endonuclease 1 overexpression by endoplasmic reticulum stress in hepatoma cells.
Inhibition of Heme Oxygenase-1 Partially Reverses the Arsenite-Mediated Decrease of CYP1A1, CYP1A2, CYP3A23, and CYP3A2 Catalytic Activity in Isolated Rat Hepatocytes.
Localization of HSP90 binding sites in the human hepatitis B virus polymerase.
Molecular chaperone GRP78/BiP interacts with the large surface protein of hepatitis B virus in vitro and in vivo.
Phosphorylation analysis of 90 kDa heat shock protein within the cytosolic arylhydrocarbon receptor complex.
Recombinant heat shock protein 65 carrying hepatitis B core antigen induces HBcAg-specific CTL response.
Regulation of Molecular Chaperone GRP78 by Hepatitis B Virus: Control of Viral Replication and Cell Survival.
Requirement of heat shock protein 90 for human hepatitis B virus reverse transcriptase function.
Role of p50/CDC37 in hepadnavirus assembly and replication.
Sequence-specific repression of cotranslational translocation of the hepatitis B virus envelope proteins coincides with binding of heat shock protein Hsc70.
Targeting hepatitis B virus antigens to dendritic cells by heat shock protein to improve DNA vaccine potency.
The Aryl-hydrocarbon receptor does not require the p23 co-chaperone for ligand binding and target gene expression in vivo.
The hsp90 Co-chaperone XAP2 alters importin beta recognition of the bipartite nuclear localization signal of the Ah receptor and represses transcriptional activity.
The role of heat shock protein 27 expression in hepatocellular carcinoma in Japan: special reference to the difference between hepatitis B and C.
Two-dimensional blue native/SDS-PAGE analysis reveals heat shock protein chaperone machinery involved in hepatitis B virus production in HepG2.2.15 cells.
[Heat shock protein 90-mediated inhibition of hepatitis B virus replication in hepatic cells].
[Immune adjuvant effect of TB.HSP70 to its accompanying cytotoxic T lymphocytes epitope elicits HBV specific immune response]
[Regulation of hepatitis B virus X protein on the expression of HSP90a gene in human hepatocarcinoma cells.]
Hepatitis B, Chronic
Expression of heat shock protein 47, transforming growth factor-beta 1, and connective tissue growth factor in liver tissue of patients with Schistosoma japonicum-induced hepatic fibrosis.
Genetic variants of heat shock protein A1L2437 and A1B1267 as possible risk factors for hepatocellular carcinoma in India.
Glucose-Regulated Protein 78 Is an Intracellular Antiviral Factor against Hepatitis B Virus.
Hepatitis B virus replication could enhance regulatory T cell activity by producing soluble heat shock protein 60 from hepatocytes.
[Expression and significance of HSP27, HSP70 and HSP90 alpha in the livers of chronic hepatitis B patients]
[Study of endoplasmic reticulum stress role in hepatic failure induced by severe hepatitis B].
Hepatitis C
A telomerase-derived peptide regulates reactive oxygen species and hepatitis C virus RNA replication in HCV-infected cells via heat shock protein 90.
Activation of the grp78 and grp94 promoters by hepatitis C virus E2 envelope protein.
Allosteric heat shock protein 70 inhibitors block hepatitis C virus assembly.
Apolipoprotein J, a glucose-upregulated molecular chaperone, stabilizes core and NS5A to promote infectious hepatitis C virus virion production.
Ca(2+) /S100 proteins regulate HCV virus NS5A-FKBP8/FKBP38 interaction and HCV virus RNA replication.
Cellular Growth Kinetics Distinguish a Cyclophilin Inhibitor from an HSP90 Inhibitor as a Selective Inhibitor of Hepatitis C Virus.
Combination therapy for hepatitis C virus with heat-shock protein 90 inhibitor 17-AAG and proteasome inhibitor MG132.
Concomitant overexpression of heat-shock protein 70 and HLA class-I in hepatitis C virus-related hepatocellular carcinoma.
Dendritic cells transfected with heat-shock protein 70 messenger RNA for patients with hepatitis C virus-related hepatocellular carcinoma: a phase 1 dose escalation clinical trial.
Destabilization of PDK1 by Hsp90 inactivation suppresses hepatitis C virus replication through inhibition of PRK2-mediated viral RNA polymerase phosphorylation.
Detection of antibodies to 65 KD heat shock protein and to human superoxide dismutase in autoimmune hepatitis-molecular mimicry between 65 KD heat shock protein and superoxide dismutase.
Heat shock protein 72 is associated with the hepatitis C virus replicase complex and enhances viral RNA replication.
Heat-shock protein 90 is essential for stabilization of the hepatitis C virus nonstructural protein NS3.
Hepatitis C virus inhibitor synergism suggests multistep interactions between heat-shock protein 90 and hepatitis C virus replication.
Hepatitis C virus RNA replication is regulated by FKBP8 and Hsp90.
Host cell factor requirement for hepatitis C virus enzyme maturation.
Inhibition of Hepatitis C Replication by Targeting the Molecular Chaperone Hsp90: Synthesis and Biological Evaluation of 4,5,6,7-Tetrahydrobenzo[1,2-d]thiazole Derivatives.
Inhibition of hepatitis C virus using siRNA targeted to the virus and Hsp90.
Interaction of hepatitis C virus core protein with Hsp60 triggers the production of reactive oxygen species and enhances TNF-alpha-mediated apoptosis.
Lycorine-derived phenanthridine downregulators of host Hsc70 as potential hepatitis C virus inhibitors.
Nonstructural 5A protein of hepatitis C virus regulates heat shock protein 72 for its own propagation.
Proteomic profiling of heat shock protein 70 family members as biomarkers for hepatitis C virus-related hepatocellular carcinoma.
Small molecular compounds that inhibit hepatitis C virus replication through destabilizing heat shock cognate 70 messenger RNA.
The heat shock cognate protein 70 is associated with hepatitis C virus particles and modulates virus infectivity.
The heat shock protein inhibitor Quercetin Attenuates hepatitis C virus production.
The interaction between human initiation factor eIF3 subunit c and heat-shock protein 90: a necessary factor for translation mediated by the hepatitis C virus internal ribosome entry site.
The Molecular Chaperone GRP78 Contributes to Toll-like Receptor 3-mediated Innate Immune Response to Hepatitis C Virus in Hepatocytes.
The NS5A-binding heat shock proteins HSC70 and HSP70 play distinct roles in the hepatitis C viral life cycle.
Tylophorine Analogs Allosterically Regulates Heat Shock Cognate Protein 70 And Inhibits Hepatitis C Virus Replication.
[Detection of serum heat shock protein 70 level in patients with hepatitis C infection and its role in cytotoxicity of CTLs induced by HSP70-HCV peptide complex]
Hepatitis C, Chronic
La protein required for internal ribosome entry site-directed translation is a potential therapeutic target for hepatitis C virus replication.
The Molecular Chaperone GRP78 Contributes to Toll-like Receptor 3-mediated Innate Immune Response to Hepatitis C Virus in Hepatocytes.
Hepatitis E
Homology model and potential virus-capsid binding site of a putative HEV receptor Grp78.
Isocotoin suppresses hepatitis E virus replication through inhibition of heat shock protein 90.
The role of Heat Shock Protein 90 (HSP90) in Hepatitis E Virus (HEV) Capsid Trafficking.
Hepatitis, Alcoholic
Circulating IgA antibody against a 65 kDa heat shock protein in acute alcoholic hepatitis.
Hepatitis, Autoimmune
Detection of antibodies to 65 KD heat shock protein and to human superoxide dismutase in autoimmune hepatitis-molecular mimicry between 65 KD heat shock protein and superoxide dismutase.
Immuno-gold electron microscopical detection of heat shock protein 60 (hsp60) in mitochondria of rat hepatocytes and myocardiocytes.
Hepatitis, Chronic
Detection of antibodies to 65 KD heat shock protein and to human superoxide dismutase in autoimmune hepatitis-molecular mimicry between 65 KD heat shock protein and superoxide dismutase.
Heat shock protein 70 serum levels differ significantly in patients with chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma.
Sequence homologies between hsp60 and autoantigens.
Hepatoblastoma
Heat shock gene expression and development of translational thermotolerance in human hepatoblastoma cells.
[Expression of GRP78 and GRP94 in the liver tissues and their clinicopathological significance in children with hepatoblastoma].
Hepatomegaly
GRP78 as a regulator of liver steatosis and cancer progression mediated by loss of the tumor suppressor PTEN.
Hepatopulmonary Syndrome
Opposite regulation of endothelial NO synthase by HSP90 and caveolin in liver and lungs of rats with hepatopulmonary syndrome.
Hepatorenal Syndrome
[Study on the expressions and roles of renal heat shock protein 72 and Toll-like receptor 4 in hepatorenal syndrome in rat]
Herpes Simplex
A cellular protein related to heat-shock protein 90 accumulates during herpes simplex virus infection and is overexpressed in transformed cells.
An intranasal heat shock protein based vaccination strategy confers protection against mucosal challenge with herpes simplex virus.
Antigenic peptides complexed to phylogenically diverse Hsp70s induce differential immune responses.
Characterization of HPV-16 E6 DNA vaccines employing intracellular targeting and intercellular spreading strategies.
Defective herpes simplex virus vectors expressing the rat brain stress-inducible heat shock protein 72 protect cultured neurons from severe heat shock.
Dual role of infections as risk factors for coronary heart disease.
Elevated antibody levels against Chlamydia pneumoniae, human HSP60 and mycobacterial HSP65 are independent risk factors in myocardial infarction and ischaemic heart disease.
Geldanamycin, a ligand of heat shock protein 90, inhibits herpes simplex virus type 2 replication both in vitro and in vivo.
Geldanamycin, a ligand of heat shock protein 90, inhibits the replication of herpes simplex virus type 1 in vitro.
Heat shock protein 27 delivered via a herpes simplex virus vector can protect neurons of the hippocampus against kainic-acid-induced cell loss.
Heat-shock protein 70 acts as an effective adjuvant in neonatal mice and confers protection against challenge with herpes simplex virus.
Heat-shock protein 90 promotes nuclear transport of herpes simplex virus 1 capsid protein by interacting with acetylated tubulin.
Heat-shock protein 90? is involved in maintaining the stability of VP16 and VP16-mediated transactivation of ? genes from herpes simplex virus-1.
Herpes simplex virus type 1 DNA polymerase requires the mammalian chaperone hsp90 for proper localization to the nucleus.
Herpes simplex virus type 2 encodes a heat shock protein homologue with apoptosis regulatory functions.
Herpes simplex virus type 2 UL14 gene product has heat shock protein (HSP)-like functions.
Herpes simplex virus-induced expression of 70 kDa heat shock protein (HSP70) requires early protein synthesis but not viral DNA replication.
Hsc70 Focus Formation at the Periphery of HSV-1 Transcription Sites Requires ICP27.
Induction of Tumor-specific Immune Response by Gene Transfer of Hsp70-cell-penetrating Peptide Fusion Protein to Tumors in Mice.
Phase I dose-escalation study of a monovalent heat shock protein 70-herpes simplex virus type 2 (HSV-2) peptide-based vaccine designed to prime or boost CD8 T-cell responses in HSV-naïve and HSV-2-infected subjects.
Publisher Correction: ?? TCR ligands: the quest to solve a 500-million-year-old mystery.
Suppression of herpes simplex virus 1 reactivation in a mouse eye model by cyclooxygenase inhibitor, heat shock protein inhibitor, and adenosine monophosphate.
Suppression of murine melanoma growth by a vaccine of attenuated Salmonella carrying heat shock protein 70 and Herpes simplex virus-thymidine kinase genes.
The Herpes Simplex Virus 1 Immediate Early Protein ICP22 Is a Functional Mimic of a Cellular J Protein.
The Torsin Activator LULL1 Is Required for Efficient Growth of Herpes Simplex Virus 1.
Transactivation of the grp78 promoter by malfolded proteins, glycosylation block, and calcium ionophore is mediated through a proximal region containing a CCAAT motif which interacts with CTF/NF-I.
Use of the glucose starvation-inducible glucose-regulated protein 78 promoter in suicide gene therapy of murine fibrosarcoma.
[Intratumor injection of recombinant attenuated salmonella carrying Mycobacterium tuberculosis heat shock protein 70 and herpes simplex virus thymidine kinase genes to suppress murine melanoma growth].
Herpes Zoster
Are Atlantic cod in Store Lungegårdsvann, a seawater recipient in Bergen, affected by environmental contaminants? A qRT-PCR survey.
Novel characterization of the HSPA2-stabilizing protein BAG6 in human spermatozoa.
Nuclear transfer technique affects mRNA abundance, developmental competence, and cell fate of the reconstituted sheep oocytes.
Proteomic Analysis of Human Blastocoel Fluid and Blastocyst Cells.
Sense and antisense transcripts of the developmentally regulated murine hsp70.2 gene are expressed in distinct and only partially overlapping areas in the adult brain.
The impact of oxidative stress on chaperone-mediated human sperm-egg interaction.
Vitellogenin, zona radiata protein, cathepsin D and heat shock protein 70 as biomarkers of exposure to xenobiotics.
Herpesviridae Infections
miR-16-1 expression, heat shock protein 70 and inflammatory reactions in astrocytes of mice with epilepsy induced by encephalitis B virus infection.
Morphofunctional characteristics of syncytiotrophoblast and content of heat shock protein 70 in it during exacerbation of herpesvirus infection in pregnant women.
Histiocytoma
Hsp90 inhibitors, GA and 17AAG, lead to ER stress-induced apoptosis in rat histiocytoma.
Histiocytoma, Malignant Fibrous
Hsp-27 has no diagnostic or prognostic significance in prostate or bladder cancers.
Hsp27 expression in neuroblastoma: correlation with disease stage.
Histoplasmosis
Agglutination of Histoplasma capsulatum by IgG monoclonal antibodies against Hsp60 impacts macrophage effector functions.
Heterologous expression, purification, and immunological reactivity of a recombinant HSP60 from Paracoccidioides brasiliensis.
Histoplasma capsulatum heat-shock 60 orchestrates the adaptation of the fungus to temperature stress.
Isolation and characterization of an immunogenic fragment of heat shock protein 60 from Trichophyton mentagrophytes.
Monoclonal antibodies to heat shock protein 60 alter the pathogenesis of Histoplasma capsulatum.
HIV Infections
Repurposing Hsp104 to Antagonize Seminal Amyloid and Counter HIV Infection.
Hodgkin Disease
Abundance of heat shock proteins (hsp89, hsp60, and hsp27) in malignant cells of Hodgkin's disease.
CD30 Induces Heat Shock Protein 90 and Signal Integration in Classic Hodgkin Lymphoma Cells.
Expression of heat shock protein 70 (HSP70) and EBV latent membrane protein 1 (LMP1) in Reed-Sternberg cells of Hodgkin's disease.
Heat shock protein 90 inhibitor BIIB021 (CNF2024) depletes NF-kappaB and sensitizes Hodgkin's lymphoma cells for natural killer cell-mediated cytotoxicity.
HSP90 is essential for Jak-STAT signaling in classical Hodgkin lymphoma cells.
Inhibition of heat shock protein 90 function by 17-allylamino-17-demethoxy-geldanamycin in Hodgkin's lymphoma cells down-regulates Akt kinase, dephosphorylates extracellular signal-regulated kinase, and induces cell cycle arrest and cell death.
Targeting Hodgkin and Reed-Sternberg Cells with an Inhibitor of Heat-Shock Protein 90: Molecular Pathways of Response and Potential Mechanisms of Resistance.
Homocystinuria
Endoplasmic Reticulum Stress and Autophagy in Homocystinuria Patients with Remethylation Defects.
HTLV-I Infections
Heat shock cognate protein 70 is a cell fusion-enhancing factor but not an entry factor for human T-cell lymphotropic virus type I.
Huntington Disease
A chemical genomics-aggrephagy integrated method studying functional analysis of autophagy inducers.
Conserved S/T Residues of the Human Chaperone DNAJB6 Are Required for Effective Inhibition of A?42 Amyloid Fibril Formation.
Correlation between chemotype-dependent binding conformations of HSP90?/? and isoform selectivity-Implications for the structure-based design of HSP90?/? selective inhibitors for treating neurodegenerative diseases.
Deciphering the Roles of Trehalose and Hsp104 in the Inhibition of Aggregation of Mutant Huntingtin in a Yeast Model of Huntington's Disease.
Effects of heat shock, heat shock protein 40 (HDJ-2), and proteasome inhibition on protein aggregation in cellular models of Huntington's disease.
GRP78 counteracts cell death and protein aggregation caused by mutant huntingtin proteins.
Hsp104 targets multiple intermediates on the amyloid pathway and suppresses the seeding capacity of Abeta fibrils and protofibrils.
Hsp90 and Its Co-Chaperones in Neurodegenerative Diseases.
Increased heat shock transcription factor 1 in the cerebellum reverses the deficiency of Purkinje cells in Alzheimer's disease.
Interaction of the molecular chaperone DNAJB6 with growing amyloid-beta 42 (A?42) aggregates leads to sub-stoichiometric inhibition of amyloid formation.
Linking HSP90 target occupancy to HSP70 induction and efficacy in mouse brain.
Molecular genetics approaches in yeast to study amyloid diseases.
Molecular Interaction between the Chaperone Hsc70 and the N-terminal Flank of Huntingtin Exon 1 Modulates Aggregation.
Neuroprotection by Hsp104 and Hsp27 in lentiviral-based rat models of Huntington's disease.
Overexpression of heat shock protein 70 in R6/2 Huntington's disease mice has only modest effects on disease progression.
Overexpression of yeast hsp104 reduces polyglutamine aggregation and prolongs survival of a transgenic mouse model of Huntington's disease.
Prefoldin prevents aggregation of ?-synuclein.
Purification of hsp104, a protein disaggregase.
Structure and function of the molecular chaperone Hsp104 from yeast.
Targeting Hsp90/Hsp70-based protein quality control for treatment of adult onset neurodegenerative diseases.
The interaction between RE1-silencing transcription factor (REST) and heat shock protein 90 as new therapeutic target against Huntington's disease.
Trehalose induces autophagy via lysosomal-mediated TFEB activation in models of motoneuron degeneration.
Widespread remodeling of proteome solubility in response to different protein homeostasis stresses.
Hydatidiform Mole
Overexpression of GRP78 in complete hydatidiform moles.
Hydronephrosis
EVEN-PLUS syndrome: A case report with novel variants in HSPA9 and evidence of HSPA9 gene dysfunction.
Hyperalgesia
Drug-Induced HSP90 Inhibition Alleviates Pain in Monoarthritic Rats and Alters the Expression of New Putative Pain Players at the DRG.
Evidence for a role of heat shock protein-90 in toll like receptor 4 mediated pain enhancement in rats.
Evidence that intrathecal morphine-3-glucuronide may cause pain enhancement via toll-like receptor 4/MD-2 and interleukin-1beta.
Moxibustion relieves visceral hyperalgesia via inhibition of transient receptor potential vanilloid 1 (TRPV1) and heat shock protein (HSP) 70 expression in rat bone marrow cells.
Protraction of neuropathic pain by morphine is mediated by spinal damage associated molecular patterns (DAMPs) in male rats.
Hyperandrogenism
Hyperandrogenism Decreases GRP78 Protein Level and Glucose Uptake in Human Endometrial Stromal Cells.
Hypercholesterolemia
Antibodies to human heat-shock protein 60 are associated with the presence and severity of coronary artery disease: evidence for an autoimmune component of atherogenesis.
Effects and mechanism of turmeric vasorelaxation of the thoracic aorta in hypercholesterolemic rats.
Soy isoflavones reduce heat shock proteins in experimental atherosclerosis.
Hyperglycemia
Analysis of serum Hsp90 as a potential biomarker of ? cell autoimmunity in type 1 diabetes.
Autoimmune diabetes induced by the beta-cell toxin STZ. Immunity to the 60-kDa heat shock protein and to insulin.
Cellular responses of novel human pancreatic ?-cell line, 1.1B4 to hyperglycemia.
Decreased tetrahydrobiopterin and disrupted association of Hsp90 with eNOS by hyperglycemia impair myocardial ischemic preconditioning.
Effect and mechanisms of zinc supplementation in protecting against diabetic cardiomyopathy in a rat model of type 2 diabetes.
Effect of hyperglycemia and hyperlipidemia on atherosclerosis in LDL receptor-deficient mice: establishment of a combined model and association with heat shock protein 65 immunity.
Effect of hyperglycemia and nitric oxide synthase inhibition on heat tolerance and induction of heat shock protein 72 kDa in vivo.
GRP78, but Not Protein-disulfide Isomerase, Partially Reverses Hyperglycemia-induced Inhibition of Insulin Synthesis and Secretion in Pancreatic {beta}-Cells.
Heat shock protein 90 (HSP90) inhibitors activate the heat shock factor 1 (HSF1) stress response pathway and improve glucose regulation in diabetic mice.
Hsp70 plays an important role in high-fat diet induced gestational hyperglycemia in mice.
Hyperglycemia adversely modulates endothelial nitric oxide synthase during anesthetic preconditioning through tetrahydrobiopterin- and heat shock protein 90-mediated mechanisms.
Hyperglycemia and antibody titres against heat shock protein 27 in traumatic brain injury patients on parenteral nutrition.
Induction of heat shock proteins by hyperglycemic cerebral ischemia.
Insulin deficiency downregulated heat shock protein 60 and IGF-1 receptor signaling in diabetic myocardium.
Involvement of endoplasmic reticulum (ER) stress in podocyte injury induced by excessive protein accumulation.
Mechanism and Consequences of The Impaired Hif-1? Response to Hypoxia in Human Proximal Tubular HK-2 Cells Exposed to High Glucose.
Mild electrical stimulation with heat shock ameliorates insulin resistance via enhanced insulin signaling.
Severity of diabetes governs vascular lipoprotein lipase by affecting enzyme dimerization and disassembly.
Targeting HSP90 Ameliorates Nephropathy and Atherosclerosis Through Suppression of NF-?B and STAT Signaling Pathways in Diabetic Mice.
Hyperhomocysteinemia
Synergistic Steatohepatitis by Moderate Obesity and Alcohol in Mice Despite Increased Adiponectin and p-AMPK.
Hyperlipidemias
Effect of hyperglycemia and hyperlipidemia on atherosclerosis in LDL receptor-deficient mice: establishment of a combined model and association with heat shock protein 65 immunity.
Excessive endoplasmic reticulum stress and decreased neuroplasticity-associated proteins in prefrontal cortex of obese rats and the regulatory effects of aerobic exercise.
Hyperlipidemia induced by a cholesterol-rich diet aggravates necrotizing pancreatitis in rats.
Stress proteins in glomerular epithelial cell injury.
Targeting HSP90 Ameliorates Nephropathy and Atherosclerosis Through Suppression of NF-?B and STAT Signaling Pathways in Diabetic Mice.
Hyperoxaluria, Primary
Structural and functional insights on the roles of molecular chaperones in the mistargeting and aggregation phenotypes associated with primary hyperoxaluria type I.
Hyperpigmentation
Induction of hyperpigmentation and heat shock protein 70 response to the toxicity of methomyl insecticide during the organ development of the Arabian toad, Bufo arabicus (Heyden,1827).
Stress chaperone mortalin regulates human melanogenesis.
Hypersensitivity
60-kDa heat shock protein of Chlamydia pneumoniae is a target of T-cell immune response.
A trans-activation domain in yeast heat shock transcription factor is essential for cell cycle progression during stress.
Antibody reactivity to the transmembrane protein of the caprine arthritis encephalitis virus correlates with severity of arthritis: no evidence for the involvement of epitope mimicry.
Differential hypersensitivity to DNase I in the regulatory region of human hsp90 beta gene in heat shock and constitutive expression.
Genetic inactivation and pharmacological blockade of sigma-1 receptors prevent paclitaxel-induced sensory-nerve mitochondrial abnormalities and neuropathic pain in mice.
HDAC6 Regulates Androgen Receptor Hypersensitivity and Nuclear Localization via Modulating Hsp90 Acetylation in Castration-Resistant Prostate Cancer.
Heat shock protein 60 activates cytokine-associated negative regulator suppressor of cytokine signaling 3 in T cells: effects on signaling, chemotaxis, and inflammation.
Heat shock protein 90 localizes to the surface and augments virulence factors of Cryptococcus neoformans.
High positive frequency of antibodies to metallothionein and heat shock protein 70 in sera of patients with metal allergy.
Human and guinea pig immune responses to Legionella pneumophila protein antigens OmpS and Hsp60.
Hypersensitivity to DNA cross-linking agents associated with up-regulation of glucose-regulated stress protein GRP78.
Hyponatremia and V2 vasopressin receptor upregulation: a result of HSP90 inhibition.
Increased sensitivity of human colon cancer cells to DNA cross-linking agents after GRP78 up-regulation.
Isolation and sequence analysis of the Chlamydia pneumoniae GroE operon.
Leishmania donovani P23 protects parasites against HSP90 inhibitor-mediated growth arrest.
Mapping the Hsp90 Genetic Network Reveals Ergosterol Biosynthesis and Phosphatidylinositol-4-Kinase Signaling as Core Circuitry Governing Cellular Stress.
Molecular and immunological characterization of the C-terminal region of a new Echinococcus granulosus Heat Shock Protein 70.
Navigating the chaperone network: an integrative map of physical and genetic interactions mediated by the hsp90 chaperone.
Perturbation of chromatin architecture on ecdysterone induction of Drosophila melanogaster small heat shock protein genes.
Preinduced intestinal HSP70 improves visceral hypersensitivity and abnormal intestinal motility in PI-IBS mouse model.
Prevalence of heat shock protein in patients with Meniere's disease and allergy.
Role of alpha beta T cells and gamma delta T cells in protective immunity to Actinobacillus actinomycetemcomitans in mutant mice by targeted gene disruption.
Role of macrophage-mediated Toll-like receptor 4-interleukin-1R signaling in ectopic tongue pain associated with tooth pulp inflammation.
Serious carbamazepine-induced hypersensitivity reactions associated with the HSP70 gene cluster.
TNF, LTA, HSPA1L and HLA-DR gene polymorphisms in HIV-positive patients with hypersensitivity to cotrimoxazole.
Transcriptional Activation of Heat-Shock Protein 90 (Hsp90) Mediated Via a Proximal Promoter Region Confers Caspofungin Resistance in Aspergillus fumigatus.
Virtual prototyping study shows increased ATPase activity of Hsp90 to be the key determinant of cancer phenotype.
[Effect of Electroacupuncture and Moxibustion on Visceral Pain and Expression of VR 1 and HSP 70 of "Tianshu" (ST 25) Region in Colorectal Distension-induced Visceral Hypersensitivity Rats].
Hypersensitivity, Delayed
Demonstration of delayed hypersensitivity in Chlamydia trachomatis salpingitis in monkeys: a pathogenic mechanism of tubal damage.
Hypertension
15-Hydroxyeicosatetraenoic acid (15-HETE) protects pulmonary artery smooth muscle cells against apoptosis via HSP90.
Activation of heat shock transcription factor 1 in rat aorta in response to high blood pressure.
Acute hypertension induces heat-shock protein 70 gene expression in rat aorta.
Angiotensin II AT1 receptor blockade abolishes brain microvascular inflammation and heat shock protein responses in hypertensive rats.
Antibodies to human heat-shock protein 60 are associated with the presence and severity of coronary artery disease: evidence for an autoimmune component of atherogenesis.
Association of elevated serum heat-shock protein 70 concentration with transient hypertension of pregnancy, preeclampsia and superimposed preeclampsia: a case-control study.
Association of polymorphisms of THBS2 and HSPA8 with hypertension in Japanese individuals with chronic kidney disease.
Atherosclerosis--an autoimmune disease due to an immune reaction against heat-shock protein 60.
Autoimmunity in the pathogenesis of hypertension.
Circulating heat shock protein 60 is associated with early cardiovascular disease.
Circulating heat shock protein and heat shock protein antibody levels in established hypertension.
COVID-19 and hypertension: is the HSP60 culprit for the severe course and worse outcome?
Elevated heat shock protein 60 levels are associated with higher risk of coronary heart disease in Chinese.
Endoplasmic reticulum stress inhibition blunts the development of essential hypertension in the spontaneously hypertensive rat.
Failure of the heat-shock protein 70 locus to cosegregate with blood pressure in spontaneously hypertensive rat x Wistar-Kyoto rat cross.
Heat shock protein 60 involvement in vascular smooth muscle cell proliferation.
Heat shock protein 72 in cardiac and skeletal muscles during hypertension.
Heat shock protein expression in hearts hypertrophied by genetic and nongenetic hypertension.
Heat Shock Protein HSP60 in Left Ventricular Cardiomyocytes of Hypertensive Rats with and without Insulin-Dependent Diabetes Mellitus.
Heat shock proteins and the kidney.
Heat stress genes in hypertension.
HSP27 locus cosegregates with left ventricular mass independently of blood pressure.
HSP60, oxidative stress parameters and cardiometabolic risk markers in hypertensive and normotensive Slovak females.
Hypothesis to explain poor outcomes in the ALLHAT and V-HeFT trials: decreased expression of heat shock proteins.
Immune reactivity to heat shock protein 70 expressed in the kidney is cause of salt-sensitive hypertension.
Inhibition of heat shock protein 90 improves pulmonary arteriole remodeling in pulmonary arterial hypertension.
Inhibitory effect of Hsp70 on angiotensin II-induced vascular smooth muscle cell hypertrophy.
Interacting contribution of the five polymorphisms in three genes of Hsp70 family to essential hypertension in Uygur ethnicity.
Interaction of heat shock protein 70 (HSP70) polymorphisms and occupational hazards increases the risk of hypertension in coke oven workers.
Lessons from Cancer: Subcellular Drug Targeting of Mitochondrial Hsp90 in Pulmonary Arterial Hypertension.
Metolazone upregulates mitochondrial chaperones and extends lifespan in Caenorhabditis elegans.
Mitochondrial HSP90 Accumulation Promotes Vascular Remodeling in Pulmonary Arterial Hypertension.
Myocardial hypoperfusion/reperfusion tolerance with exercise training in hypertension.
New Insights Into Heat Shock Protein 90 in the Pathogenesis of Pulmonary Arterial Hypertension.
PARM-1 is an endoplasmic reticulum molecule involved in endoplasmic reticulum stress-induced apoptosis in rat cardiac myocytes.
Serum heat shock protein 70 levels predict the development of atherosclerosis in subjects with established hypertension.
Targeting HSP90 attenuates angiotensin II-induced adventitial remodeling via suppression of mitochondrial fission.
The atheroprotective properties of Hsp70: a role for Hsp70-endothelial interactions?
The discovery of hypertension: evolving views on the role of the kidneys, and current hot topics.
Upregulation of GRP78 and caspase-12 in diastolic failing heart.
Vascular expression of heat shock protein 72 in fructose-induced hypertensive rats.
[Content of the major heat shock protein HSP70 in rats with hereditary stress-induced arterial hypertension]
[Preliminary study on relationship between antibody against heat stress protein 70 and hypertension]
[Relation of HSP70 gene and spontaneously hypertension in rats]
[Role of endoplasmic reticulum stress-related molecule GRP78 in global cerebral ischemia-reperfusion injury aggravated by hypertension in rats].
[The expression of heat shock protein 27 in retinal ganglion cells in the rat glaucoma model.]
Hypertension, Malignant
Expression of 90-kDa heat shock protein within regenerative tubular cells in a patient with acute oliguric renal failure due to malignant hypertension.
Hypertension, Portal
Graft injury in relation to graft size in right lobe live donor liver transplantation: a study of hepatic sinusoidal injury in correlation with portal hemodynamics and intragraft gene expression.
Heat shock protein 90 is responsible for hyperdynamic circulation in portal hypertensive rats.
Hsp90 regulation of endothelial nitric oxide synthase contributes to vascular control in portal hypertension.
Role of HSP-90 for increased nNOS-mediated vasodilation in mesenteric arteries in portal hypertension.
Hypertension, Pregnancy-Induced
Assessment of placental and maternal stress responses in patients with pregnancy related complications via monitoring of heat shock protein mRNA levels.
Circulating heat shock protein mRNA profile in gestational hypertension, pre-eclampsia & foetal growth restriction.
Hypertension, Pulmonary
Beta-actin: a regulator of NOS-3.
Decreased association of HSP90 impairs endothelial nitric oxide synthase in fetal lambs with persistent pulmonary hypertension.
Diminished gene expression of cardiac heat shock proteins in pulmonary hypertensive chickens.
Inducible HSP70 regulates superoxide dismutase-2 and mitochondrial oxidative stress in the endothelial cells from developing lungs.
Nitric oxide and superoxide generation from endothelial NOS: modulation by HSP90.
Protein complex formation with heat shock protein 90 in chronic hypoxia-induced pulmonary hypertension in newborn piglets.
Variation of heat shock protein gene expression in the brain of cold-induced pulmonary hypertensive chickens.
[Effect of heat shock protein 70 on pulmonary vascular remodeling in neonatal rats with hypoxic pulmonary hypertension].
[Hypoxia stimulates the expression of HSP70 in pulmonary artery smooth muscle cells]
[Protective effects of heat shock protein 70 against hypoxic pulmonary hypertension in neonatal rats].
Hyperthyroidism
Effect of thyroid hormone on mtHsp70 expression, mitochondrial import and processing in cardiac muscle.
Effects of thyroid hormone on ovarian cell apoptosis in the rat.
Heat shock protein 70 (HSP70) and complement C4 genotypes in patients with hyperthyroid Graves' disease.
Hyperthyroid hearts display a phenotype of cardioprotection against ischemic stress: a possible involvement of heat shock protein 70.
Investigation of the effect of hyperthyroidism on endoplasmic reticulum stress and tran- sient receptor potential canonical 1 channel in the kidney
Hypertrophy, Left Ventricular
Left ventricular hypertrophy is associated with overexpression of HSP60, TLR2, and TLR4 in the myocardium.
The Protective Effect of Lacidipine on Myocardial Remodeling Is Mediated by the Suppression in Expression of GPR78 and CHOP in Rats.
Hypertrophy, Right Ventricular
[The role of endoplasmic reticulum stress in pulmonary hypertension in rat induced by chronic hypoxia and hypercapnia].
Hypoalbuminemia
The role of albumin and endoplasmic reticulum in pathogenesis Preeclampsia. Changes of GRP78 and placental VEGF in preeclampsia.
Hypoglycemia
Amelioration of hypoxic and hypoglycemic damage to cerebral endothelial cells. Effects of heat shock pretreatment.
Constitutively active heat shock factor 1 enhances glucose-driven insulin secretion.
Differential neuroprotection from human heat shock protein 70 overexpression in in vitro and in vivo models of ischemia and ischemia-like conditions.
Exogenous heat shock cognate protein 70 pretreatment attenuates cardiac and hepatic dysfunction with associated anti-inflammatory responses in experimental septic shock.
Expression of glucose-regulated proteins (GRP78 and GRP94) in hearts and fore-limb buds of mouse embryos exposed to hypoglycemia in vitro.
Glucose-regulated protein 78 (GRP78) is elevated in embryonic mouse heart and induced following hypoglycemic stress.
Hypoglycemia enhances the expression of prion protein and heat-shock protein 70 in a mouse neuroblastoma cell line.
Repositioning of Verrucosidin, a purported inhibitor of chaperone protein GRP78, as an inhibitor of mitochondrial electron transport chain complex I.
Hypokalemic Periodic Paralysis
Expression of heat shock protein epitopes in tubular aggregates.
Hyponatremia
Hyponatremia and V2 vasopressin receptor upregulation: a result of HSP90 inhibition.
Hypoparathyroidism
Ahsa1 and Hsp90 activity confers more severe craniofacial phenotypes in a zebrafish model of hypoparathyroidism, sensorineural deafness and renal dysplasia (HDR).
Hypopharyngeal Neoplasms
Knockdown of glucose-regulated protein 78 abrogates chemoresistance of hypopharyngeal carcinoma cells to cisplatin induced by unfolded protein in response to severe hypoxia.
Hypotension
Exogenous heat shock cognate protein 70 pretreatment attenuates cardiac and hepatic dysfunction with associated anti-inflammatory responses in experimental septic shock.
Heat shock protein 72 may improve hypotension by increasing cardiac mechanical efficiency and arterial elastance in heatstroke rats.
Oxidative stress and ischemic injuries in heat stroke.
Pathogenesis of an experimental heatstroke model.
Potentiation of baroreceptor reflex response by heat shock protein 70 in nucleus tractus solitarii confers cardiovascular protection during heatstroke.
Progressive exercise preconditioning protects against circulatory shock during experimental heatstroke.
Hypothyroidism
Effects of hypothyroidism and aortic construction on mitochondria during cardiac hypertrophy.
Effects of thyroid hormone on ovarian cell apoptosis in the rat.
Hypothyroidism selectively reduces the rate and amount of transport for specific SCb proteins in the hyt/hyt mouse optic nerve.
Hypoxia, Brain
Early diffusion weighted imaging and expression of heat shock protein 70 in newborn pigs with hypoxic ischaemic encephalopathy.
Idiopathic Pulmonary Fibrosis
A Fit-for-Purpose Method for the Detection of Human Antibodies to Surface-Exposed Components of BMS-986263, a Lipid Nanoparticle-Based Drug Product Containing a siRNA Drug Substance.
Alpha-defensin enhances expression of HSP47 and collagen-1 in human lung fibroblasts.
Analysis of heat shock protein 70 gene polymorphisms Mexican patients with idiopathic pulmonary fibrosis.
Grp78 Loss in Epithelial Progenitors Reveals an Age-linked Role for Endoplasmic Reticulum Stress in Pulmonary Fibrosis.
Heat shock protein-90 toward theranostics: a breath of fresh air in idiopathic pulmonary fibrosis.
Heat shock protein: a hot topic in idiopathic pulmonary fibrosis.
HSP90 Inhibition and Modulation of the Proteome: Therapeutical Implications for Idiopathic Pulmonary Fibrosis (IPF).
Involvement of collagen-binding heat shock protein 47 and procollagen type I synthesis in idiopathic pulmonary fibrosis: contribution of type II pneumocytes to fibrosis.
Patients with idiopathic pulmonary fibrosis with antibodies to heat shock protein 70 have poor prognoses.
Screening of Inhibitors Targeting Heat Shock Protein 47 Involved in the Development of Idiopathic Pulmonary Fibrosis.
Serum heat shock protein 47 levels are elevated in acute exacerbation of idiopathic pulmonary fibrosis.
Immune System Diseases
Administration of heat shock protein 65 inhibits murine melanoma growth in vivo.
Heat shock protein 70-2 and tumor necrosis factor-? gene polymorphisms in Chinese children with Henoch-Schönlein purpura.
Highly Selective Activation of Heat Shock Protein 70 by Allosteric Regulation Provides an Insight into Efficient Neuroinflammation Inhibition.
Infarction, Middle Cerebral Artery
Comparative analysis of the neuroprotective effects of ginsenosides Rg1 and Rb1 extracted from Panax notoginseng against cerebral ischemia.
Ferulic Acid Exerts Anti-apoptotic Effects against Ischemic Injury by Activating HSP70/Bcl-2- and HSP70/Autophagy-Mediated Signaling after Permanent Focal Cerebral Ischemia in Rats.
HSP27 Protects the Blood-Brain Barrier Against Ischemia-Induced Loss of Integrity.
Hypothermia enhances heat-shock protein 70 production in ischemic brains.
Induction of heat shock protein 40 and GrpE mRNAs following transient focal cerebral ischemia in the rat.
Influence of electroacupuncture on the mRNA of heat shock protein 70 and 90 in brain after cerebral ischemia/reperfusion of rats.
Mitochondrial serine protease Omi/HtrA2 accentuates brain ischemia/reperfusion injury in rats and oxidative stress injury in vitro by modulating mitochondrial stress proteins CHOP and ClpP and physically interacting with mitochondrial fusion protein OPA1.
Modest MRI signal intensity changes precede delayed cortical necrosis after transient focal ischemia in the rat.
Neuronal survival is associated with 72-kDa heat shock protein expression after transient middle cerebral artery occlusion in the rat.
NO-induced downregulation of HSP10 and HSP60 expression in the postischemic brain.
Occurrence of heat shock response in deafferented neurons in the substantia nigra of rats.
Phosphorylated recombinant HSP27 protects the brain and attenuates blood-brain barrier disruption following stroke in mice receiving intravenous tissue-plasminogen activator.
Resveratrol preconditioning induces cellular stress proteins and is mediated via NMDA and estrogen receptors.
Temporal Profiles of Stress Protein Inductions after Focal Transient Ischemia in Mice Brain.
The influence of delayed postischemic hyperthermia following transient focal ischemia: alterations of gene expression.
[Effects of Naomaitong Recipe on expressions of nuclear factor-kappaB and nitric-oxide synthases in brain tissue after focal cerebral ischemia reperfusion in aged rats.]
Infections
A cellular protein related to heat-shock protein 90 accumulates during herpes simplex virus infection and is overexpressed in transformed cells.
A Class II small heat shock protein OsHsp18.0 plays positive roles in both biotic and abiotic defense responses in rice.
A comparative analysis of the products of GROEL-1 gene from Chlamydia trachomatis serovar D and the HSP60 var1 transcript from Homo sapiens suggests a possible autoimmune response.
A hypothetical model of crossing Bombyx mori nucleopolyhedrovirus through its host midgut physical barrier.
A mucosal subunit vaccine protects against lethal respiratory infection with Francisella tularensis LVS.
A Mycobacterium tuberculosis mutant lacking the groEL homologue cpn60.1 is viable but fails to induce an inflammatory response in animal models of infection.
A new role for heat shock factor 27 in the pathophysiology of Clostridium difficile toxin B.
A quantitative assay method of Toxoplasma gondii HSP70 mRNA by quantitative competitive-reverse transcriptase-PCR.
A relationship between serological markers of chronic C. pneumoniae and CMV infection and hsp60 in patients with atherosclerotic carotid stenosis.
A review of recent patents on the protozoan parasite HSP90 as a drug target.
A simple and rapid method for the purification of GroEL, an Escherichia coli homolog of the heat shock protein 60 family of molecular chaperonins.
A virulence factor of Helicobacter pylori: role of heat shock protein in mucosal inflammation after H. pylori infection.
Activation of c-Jun N-terminal kinase by Akabane virus is required for apoptosis.
Activation of c-jun N-terminal kinase upon influenza A virus (IAV) infection is independent of pathogen-related receptors but dependent on amino acid sequence variations of IAV NS1.
Activation of T cells recognizing an epitope of heat-shock protein 70 can protect against rat adjuvant arthritis.
Activation of the mitogen-activated protein kinase p38 by human cytomegalovirus infection through two distinct pathways: a novel mechanism for activation of p38.
Activation of transcription factor Nrf-2 and its downstream targets in response to moloney murine leukemia virus ts1-induced thiol depletion and oxidative stress in astrocytes.
Acute infection of Sindbis virus induces phosphorylation and intracellular translocation of small heat shock protein HSP27 and activation of p38 MAP kinase signaling pathway.
Aeromonas hydrophila infection in silver catfish causes hyperlocomotion related to stress.
Aggregate-reactivation activity of the molecular chaperone ClpB from Ehrlichia chaffeensis.
Airflow limitation, asthma, and Chlamydia pneumoniae-specific heat shock protein 60.
An assay combining cell culture with reverse transcriptase PCR to detect and determine the infectivity of waterborne Cryptosporidium parvum.
An ELISA using recombinant TmHSP70 for the diagnosis of Taenia multiceps infections in goats.
An improved vaccine for prevention of respiratory tularemia caused by Francisella tularensis SchuS4 strain.
Analysis of Caenorhabditis elegans phosphoproteome reveals the involvement of a molecular chaperone, HSP-90 protein during Salmonella enterica Serovar Typhi infection.
Analysis of Chlamydia pneumoniae growth in cells by reverse transcription-PCR targeted to bacterial gene transcripts.
Analysis of heat shock protein 60 encoding genes of mycoplasmas and investigations concerning their role in immunity and infection.
Analysis of heat-induced changes in protein expression of Stenotrophomonas maltophilia K279a reveals a role for GroEL in the host-temperature adaptation.
Analysis of porcine differential gene expression following challenge with Salmonella enterica serovar Choleraesuis using suppression subtractive hybridization.
Analysis of the humoral immune response against total and recombinant antigens of Leishmania infantum: correlation with disease progression in canine experimental leishmaniasis.
Analysis of the Mycobacterium bovis hsp60 promoter activity in recombinant Mycobacterium avium.
Anaplasma marginale infection in a Japanese Black cow 13 years after eradication of Rhipicephalus (Boophilus) microplus in Okinawa, Japan.
Anaplasma phagocytophilum MSP4 and HSP70 Proteins Are Involved in Interactions with Host Cells during Pathogen Infection.
Anti-HIV activity of olive leaf extract (OLE) and modulation of host cell gene expression by HIV-1 infection and OLE treatment.
Antibodies specific for heat shock proteins in human and murine malaria.
Antibodies to human heat-shock protein 60 are associated with the presence and severity of coronary artery disease: evidence for an autoimmune component of atherogenesis.
Antibody response to GroEL varies in patients with acute Mycoplasma pneumoniae infection.
Antibody to Mycobacterium tuberculosis 65 kDa heat shock protein in patients with rheumatoid arthritis--a survey of antigen-specific antibody isotypes and subclasses in an endemic area of previous tuberculosis infection.
Antiviral activity and RNA polymerase degradation following Hsp90 inhibition in a range of negative strand viruses.
Antiviral and Anti-Inflammatory Activities of Pochonin D, a Heat Shock Protein 90 Inhibitor, against Rhinovirus Infection.
Aquatic birnavirus-induced ER stress-mediated death signaling contribute to downregulation of Bcl-2 family proteins in salmon embryo cells.
AR-12 suppresses dengue virus replication by down-regulation of PI3K/AKT and GRP78.
Assessment of Apical Expression of Alpha-2 Integrin, Heat Shock Protein, and Proinflammatory and Immunoregulatory Cytokines in Response to Endodontic Infection.
Association between antibodies to heat shock protein 65 and coronary atherosclerosis. Possible mechanism of action of Helicobacter pylori and other bacterial infections in increasing cardiovascular risk.
Astragalus polysaccharides attenuate PCV2 infection by inhibiting endoplasmic reticulum stress in vivo and in vitro.
Attenuated aroA Salmonella enterica serovar Typhimurium does not induce inflammatory response and early protection of gnotobiotic pigs against parental virulent LT2 strain.
Autoantibodies to a specific peptide epitope of human Hsp60 (ATVLA) with homology to Helicobacter pylori HspB in H. pylori-infected patients.
Autographa californica nucleopolyhedrovirus infection of Spodoptera frugiperda cells: a global analysis of host gene regulation during infection, using a differential display approach.
Autoimmune diseases and Helicobacter pylori infection.
Autoimmunity to human heat shock protein 60, Chlamydia pneumoniae infection, and inflammation in predicting coronary risk.
Autophagy induction by the pathogen receptor NECTIN4 and sustained autophagy contribute to peste des petits ruminants virus infectivity.
Autophagy is involved in regulating influenza A virus RNA and protein synthesis associated with both modulation of Hsp90 induction and mTOR/p70S6K signaling pathway.
Autophagy machinery promotes the chaperone-mediated formation and compartmentalization of protein aggregates during appressorium development by the rice blast fungus.
Bacterial infection elicits heat shock protein 72 release from pleural mesothelial cells.
Bacteriophage phi 105clz induces the GroEL-homologue protein in Bacillus subtilis.
Bag2 Is a Component of a Cytosolic Extraction Machinery That Promotes Membrane Penetration of a Nonenveloped Virus.
Bartonella bacilliformis GroEL: Effect on Growth of Human Vascular Endothelial Cells in Infected Cocultures.
Bartonella strains from ground squirrels are identical to Bartonella washoensis isolated from a human patient.
Betanodavirus up-regulates chaperone GRP78 via ER stress: roles of GRP78 in viral replication and host mitochondria-mediated cell death.
Bombyx mori cell division cycle protein 37 promotes the proliferation of BmNPV.
Borrelia burgdorferi Surface Exposed GroEL Is a Multifunctional Protein.
Caprine humoral response to Burkholderia pseudomallei antigens during acute melioidosis from aerosol exposure.
Capsid protein-mediated recruitment of host DnaJ-like proteins is required for Potato virus Y infection in tobacco plants.
Carotenoid-based plumage colouration is associated with blood parasite richness and stress protein levels in blue tits (Cyanistes caeruleus).
CD4(+) v(alpha)14 NKT cells play a crucial role in an early stage of protective immunity against infection with Leishmania major.
Cell type-specific variations in the induction of hsp70 in human leukocytes by feverlike whole body hyperthermia.
Cellular and molecular regulation of vaccination with heat shock protein 60 from Histoplasma capsulatum.
Changes in the proteome of pad2-1, a glutathione depleted Arabidopsis mutant, during Pseudomonas syringae infection.
Chaperone fusion proteins aid entropy-driven maturation of class II viral fusion proteins.
Chaperonin GroEL: a novel phylogenetically conserved protein with strong immunoreactivity of Avian Pathogenic Escherichia coli isolates from duck identified by immunoproteomics.
Characterization of Anaplasma spp. infection in dogs from Costa Rica.
Characterization of the main immunogenic proteins in Brucella infection for their application in diagnosis of brucellosis.
Characterization of the molecular chaperone ClpB from the pathogenic spirochaete Leptospira interrogans.
Chemotherapeutic potential of 17-AAG against cutaneous leishmaniasis caused by Leishmania (Viannia) braziliensis.
Chicken heat shock protein 90 is a component of the putative cellular receptor complex of infectious bursal disease virus.
Chlamydia pneumoniae heat shock protein 60 enhances expression of ERK, TLR-4 and IL-8 in atheromatous plaques of coronary artery disease patients.
Chlamydia pneumoniae infection acts as an endothelial stressor with the potential to initiate the earliest heat shock protein 60-dependent inflammatory stage of atherosclerosis.
Chlamydia pneumoniae infection of alveolar macrophages: a model.
Chlamydia pneumoniae stimulates proliferation of vascular smooth muscle cells through induction of endogenous heat shock protein 60.
Chlamydia pneumoniae, heat shock proteins 60 and risk of secondary cardiovascular events in patients with coronary heart disease under special consideration of diabetes : a prospective study.
Chlamydia trachomatis Infection Is Related to Poor Semen Quality in Young Prostatitis Patients.
Chlamydia trachomatis: The persistent pathogen.
Chlamydial antibodies in patients with previous acute anterior uveitis.
Chlamydial serology: comparative diagnostic value of immunoblotting, microimmunofluorescence test, and immunoassays using different recombinant proteins as antigens.
Chlamydophila pneumoniae infection leads to smooth muscle cell proliferation and thickening in the coronary artery without contributions from a host immune response.
Circulating antibodies to the 60-kD heat shock protein (hsp) family in patients with Helicobacter pylori infection.
Circulating heat shock protein 70 (Hsp70) in elderly members of a rural population from Cameroon: Association with infection and nutrition.
Circulating heat shock proteins in women with a history of recurrent vulvovaginitis.
Circulating heat-shock protein 70 is associated with postoperative infection and organ dysfunction after liver resection.
Clinical Consequences of Immune Response to CT Upper Genital Tract Infection in Women.
Cloning and kinetics of expression of Brucella abortus heat shock proteins by baculovirus recombinants.
Cloning of Hsp21 gene and its expression in Chinese shrimp Fenneropenaeus chinensis in response to WSSV challenge.
Cloning, expression and characterization of heat shock protein 60 (groEL) of Salmonella enterica serovar Typhi and its role in protective immunity against lethal Salmonella infection in mice.
Cloning, purification and characterization of a 90kDa heat shock protein from Citrus sinensis (sweet orange).
Co-expression of S. Typhi GroEL and IL-22 gene augments immune responses against Salmonella infection.
Combined treatments with interferon (alpha,beta) plus PGA1 to control early infection with HTLV-I in primary cord blood-derived mononuclear cells.
Comparative analysis of antibody responses against HSP60, invariant surface glycoprotein 70, and variant surface glycoprotein reveals a complex antigen-specific pattern of immunoglobulin isotype switching during infection by Trypanosoma brucei.
Comparative analysis of differential gene expression of HSP40 and HSP70 family isoforms during heat stress and HIV-1 infection in T-cells.
Comparison of PCR methods for detection of Leishmania siamensis infection.
Comparison of Recombinant Proteins of Kinesin 39, Heat Shock Protein 70, Heat Shock Protein 83 and Glycoprotein 63 for Antibody Detection of Leishmania martiniquensis Infection.
Complex spatial responses to cucumber mosaic virus infection in susceptible Cucurbita pepo cotyledons.
Conservation of Babesia bovis small heat shock protein (Hsp20) among strains and definition of T helper cell epitopes recognized by cattle with diverse major histocompatibility complex class II haplotypes.
Constitutive expression of a groEL-related protein on the surface of human gamma/delta cells.
Construction of recombinant neisserial Hsp60 proteins and mapping of antigenic domains.
Construction, expression and identification of a recombinant BCG vaccine encoding human mycobacterium tuberculosis heat shock protein 65.
Contribution of 65-kDa heat shock protein induced by gamma and delta T cells to protection against Toxoplasma gondii infection.
Contribution of anti-Hsp70.1 IgG antibody levels to the diagnostic certainty of clinically suspected ocular toxoplasmosis.
Correction: Heat shock protein 90 positively regulates chikungunya virus replication by stabilizing viral non-structural protein nsP2 during infection.
Cross-reactive antigens shared by Pseudomonas aeruginosa, Helicobacter pylori, Campylobacter jejuni, and Haemophilus influenzae may cause false-positive titers of antibody to H. pylori.
CSFV Infection Up-Regulates the Unfolded Protein Response to Promote Its Replication.
CSFV protein NS5A activates the unfolded protein response to promote viral replication.
Cucumber Necrosis Virus Recruits Cellular Heat Shock Protein 70 Homologs at Several Stages of Infection.
Current progress in proteomic study of hepatitis C virus-related human hepatocellular carcinoma.
Cutaneous leishmaniasis caused by Leishmania donovani in the tribal population of the Agasthyamala Biosphere Reserve forest, Western Ghats, Kerala, India.
Cytokine and estrogen stimulation of endothelial cells augments activation of the prekallikrein-high molecular weight kininogen complex: Implications for hereditary angioedema.
Cytokine secretion by CD4 T lymphocytes acquired in response to Mycobacterium tuberculosis infection.
Cytoskeletal Alteration Is an Early Cellular Response in Pulmonary Epithelium Infected with Aspergillus fumigatus Rather than Scedosporium apiospermum.
Demonstration of delayed hypersensitivity in Chlamydia trachomatis salpingitis in monkeys: a pathogenic mechanism of tubal damage.
Dengue virus entry into liver (HepG2) cells is independent of hsp90 and hsp70.
Dengue virus infection induces GRP78 which acts to chaperone viral antigen production.
Detection of candidal antigens in autoimmune polyglandular syndrome type I.
Detection of human pathogenic Ehrlichia muris-like agent in Peromyscus leucopus.
Detrimental Effect of Fungal 60-kDa Heat Shock Protein on Experimental Paracoccidioides brasiliensis Infection.
Differences in structure and changes in gene regulation of murrel molecular chaperone HSP family during epizootic ulcerative syndrome (EUS) infection.
Does serologic evidence of remote Chlamydia trachomatis infection and its heat shock protein (CHSP 60) affect in vitro fertilization-embryo transfer outcome?
Duck enteritis virus infection suppresses viability and induces apoptosis and endoplasmic reticulum stress in duck embryo fibroblast cells via the regulation of Ca2.
Dynamics of heat shock protein 70 concentrations in peripheral blood lymphocyte lysates during pregnancy in lactating Holstein-Friesian cows.
Early antibody response and clinical outcome in experimental canine leishmaniasis.
Early appearing gamma/delta-bearing T cells during infection with Calmétte Guérin bacillus.
Effect of adjuvants on immune response and protective immunity elicited by recombinant Hsp60 (GroEL) of Salmonella typhi against S. typhi infection.
Effect of bacterial flora on postimmunization gastritis following oral vaccination of mice with Helicobacter pylori heat shock protein 60.
Effect of human papillomavirus infection on estrogen receptor and heat shock protein hsp27 phenotype in human cervix and vagina.
Effect of multiple microsporidian infections and temperature stress on the heat shock protein 70 (hsp70) response of the amphipod Gammarus pulex.
Effect of periodontal treatment on the serum antibody levels to heat shock proteins.
Effect of Staphylococcus aureus infection on the heat stress protein 70 (HSP70) level in chicken embryo tissues.
Effects of cyclopentenone prostaglandins on myeloid cells during early infection with HTLV-I. II. Regulation of synthesis of inducible p72 heat shock protein.
Effects of Helicobacter pylori and Heat Shock Protein 70 on the Proliferation of Human Gastric Epithelial Cells.
Effects of hesperidin on the growth performance, antioxidant capacity, immune responses and disease resistance of red swamp crayfish (Procambarus clarkii).
Effects of Mycobacterium tuberculosis Mutant Strain Hsp16.3 Gene on Murine RAW 264.7 Macrophage Autophagy.
Effects of repeated Chlamydia pneumoniae inoculations on aortic lipid accumulation and inflammatory response in C57BL/6J mice.
Elevated levels of Legionella pneumophila stress protein Hsp60 early in infection of human monocytes and L929 cells correlate with virulence.
Elevated serum heat-shock protein 70 levels in patients with acute infection: use of an optimized enzyme-linked immunosorbent assay.
Elucidation of the Inhibitory Mechanisms of Nipponoparmelia laevior Lichen Extract against Influenza A (H1N1) Virus through Proteomic Analyses.
Emerging cellular targets for influenza antiviral agents.
Endoplasmic reticulum chaperone gp96 is essential for infection with vesicular stomatitis virus.
Endoplasmic Reticulum Stress Aggravates Viral Myocarditis by Raising Inflammation Through the IRE1-Associated NF-?B Pathway.
Endoplasmic reticulum stress-mediated autophagy contributes to bluetongue virus infection via the PERK-eIF2? pathway.
Enhanced levels of Staphylococcus aureus stress protein GroEL and DnaK homologs early in infection of human epithelial cells.
Enhanced resistance against Vibrio harveyi infection by carvacrol and its association with the induction of heat shock protein 72 in gnotobiotic Artemia franciscana.
Epidemiology, genetic variants and clinical course of natural infections with Anaplasma phagocytophilum in a dairy cattle herd.
Epigenetic modulation, stress and plasticity in susceptibility of the snail host, Biomphalaria glabrata, to Schistosoma mansoni infection.
Epitopes of Immunoreactive Proteins of Streptococcus Agalactiae: Enolase, Inosine 5'-Monophosphate Dehydrogenase and Molecular Chaperone GroEL.
Escherichia coli grpE gene codes for heat shock protein B25.3, essential for both lambda DNA replication at all temperatures and host growth at high temperature.
Ethanol facilitates HCV replication via upregulation of GW182 and HSP90 in human hepatoma cells.
Eukaryotic heat shock proteins as molecular links in innate and adaptive immune responses: Hsp60-mediated activation of cytotoxic T cells.
Evaluation of Newcastle disease virus mediated dendritic cell activation and cross-priming tumor-specific immune responses ex vivo.
Evaluation of the recombinant Heat shock protein B (HspB) of Coxiella burnetii as a potential antigen for immunodiagnostic of Q fever in goats.
Evidence for disruption of Na(+)-K(+)-ATPase and hsp70 during vibriosis of sea bream, Sparus (=Rhabdosargus) sarba Forsskål.
Evidence for the early recruitment of T-cell receptor gamma delta+ T cells during rat listeriosis.
Exogenous heat shock protein 27 uniquely blocks differentiation of monocytes to dendritic cells.
Experimental cauda equina compression induces HSP70 synthesis in dog.
Experimental Trial with a Heat-Shocked Protoscolex Extract as a Vaccine Candidate for Protection Against Hydatid Disease.
Exposure of gnotobiotic Artemia franciscana larvae to abiotic stress promotes heat shock protein 70 synthesis and enhances resistance to pathogenic Vibrio campbellii.
Expression analysis of heat shock protein genes during Aeromonas hydrophila infection in rohu, Labeo rohita, with special reference to molecular characterization of Grp78.
Expression of 65- and 67-kilodalton heat-regulated proteins and a 70-kilodalton heat shock cognate protein of Leishmania donovani in macrophages.
Expression of Heat shock protein 70 (Hsp70-1) in Plasmodium berghei ookinetes and its participation in midgut mosquito infection.
Expression of heat shock protein 90 genes during early development and infection in Megalobrama amblycephala and evidence for adaptive evolution in teleost.
Expression of heat shock proteins and subolesin affects stress responses, Anaplasma phagocytophilum infection and questing behaviour in the tick, Ixodes scapularis.
Expression of Helicobacter pylori Hsp60 protein and its immunogenicity.
Expression of recombinant heat-shock protein 70 of MCAN/IR/96/LON-49, a tool for diagnosis and future vaccine research.
Expression pattern of heat-shock cognate 70 gene of humphead snapper, Lutjanus sanguineus (Cuvier), infected by Vibrio harveyi.
Expression Profiling of Plasmodium berghei HSP70 Genes for Generation of Bright Red Fluorescent Parasites.
Extracellular Hsp90 serves as a co-factor for MAPK activation and latent viral gene expression during de novo infection by KSHV.
Extracellular Hsp90 serves as a co-factor for NF-?B activation and cellular pathogenesis induced by an oncogenic herpesvirus.
Feeding Artemia franciscana (Kellogg) larvae with bacterial heat shock protein, protects from Vibrio campbellii infection.
First detection of the Anaplasma phagocytophilum groEL-A genotype in man.
Flavivirus Nonstructural Protein NS5 Dysregulates HSP90 to Broadly Inhibit JAK/STAT Signaling.
Formation of aggresome-like structures in herpes simplex virus type 2-infected cells and a potential role in virus assembly.
Frequency and Magnitude of Chlamydia trachomatis Elementary Body- and Heat Shock Protein 60-Stimulated Interferon gamma Responses in Peripheral Blood Mononuclear Cells and Endometrial Biopsy Samples from Women with High Exposure to Infection.
Frequency of antigen-specific B cells during experimental ocular Chlamydia trachomatis infection.
Functional role of Hsp60 as a positive regulator of human viral infection progression.
Functional roles of GRP78 in hepatitis B virus infectivity and antigen secretion.
Functional similarities between the small heat shock proteins Mycobacterium tuberculosis HSP 16.3 and human alphaB-crystallin.
Functional surface proteomic profiling reveals the host heat-shock protein A8 as a mediator of Lichtheimia corymbifera recognition by murine alveolar macrophages.
Fusobacterium nucleatum GroEL induces risk factors of atherosclerosis in human microvascular endothelial cells and ApoE(-/-) mice.
Gene expression and in situ protein profiling of candidate SARS-CoV-2 receptors in human airway epithelial cells and lung tissue.
Gene transfer into hippocampal slice cultures with an adenovirus vector driven by cytomegalovirus promoter: stable co-expression of green fluorescent protein and lacZ genes.
Genetic differences in the Chlamydia trachomatis tryptophan synthase alpha-subunit can explain variations in serovar pathogenesis.
Genetic diversity of groEL and msp4 sequences of Anaplasma ovis infecting camels from Tunisia.
Global Transcriptomic Analysis Reveals Insights into the Response of 'Etrog' Citron (Citrus medica L.) to Citrus Exocortis Viroid Infection.
Glucose-regulated protein 78 is an antiviral against hepatitis A virus replication.
Glucose-Regulated Protein 78 Is an Intracellular Antiviral Factor against Hepatitis B Virus.
GroEL protein of the Leptospira spp. interacts with host proteins and induces cytokines secretion on macrophages.
GroEL provides protection against Bacillus anthracis infection in BALB/c mice.
GRP78, a coreceptor for coxsackievirus A9, interacts with major histocompatibility complex class I molecules which mediate virus internalization.
Habitat effects on physiological stress response in nestling blue tits are mediated through parasitism.
Harnessing Hsp90 function as a powerful, broadly effective therapeutic strategy for fungal infectious disease.
Heat shock protein 70 (HSP70) in gastric adaptation to aspirin in Helicobacter pylori infection.
Heat shock cognate 70 gene in Haliotis diversicolor: responses to pathogen infection and environmental stresses and its transcriptional regulation analysis.
Heat shock cognate 70 is a prominent immunogen in Brugian filariasis.
Heat shock cognate protein 70 contributes to Brucella invasion into trophoblast giant cells that cause infectious abortion.
Heat shock cognate protein 70 gene is required for prevention of apoptosis induced by WSSV infection.
Heat shock cognate protein 70 is a cell fusion-enhancing factor but not an entry factor for human T-cell lymphotropic virus type I.
Heat shock cognate protein 70 isoform D is required for clathrin-dependent endocytosis of Japanese encephalitis virus in C6/36cells.
Heat shock protein 20 from Procambarus clarkii is involved in the innate immune responses against microbial infection.
Heat shock protein 27 is involved in PCV2 infection in PK-15 cells.
Heat shock protein 60 and immune inflammatory responses in atherosclerosis.
Heat shock protein 60 autoimmunity and early lipid lesions in cholesterol-fed C57BL/6JBom mice during Chlamydia pneumoniae infection.
Heat shock protein 60 specific T-cell response in chlamydial infections.
Heat shock protein 60 stimulates the migration of vascular smooth muscle cells via Toll-like receptor 4 and ERK MAPK activation.
Heat Shock Protein 60, Insights to Its Importance in Histoplasma capsulatum: From Biofilm Formation to Host-Interaction.
Heat shock protein 65 induced by gammadelta T cells prevents apoptosis of macrophages and contributes to host defense in mice infected with Toxoplasma gondii.
Heat shock protein 70 (Hsp70) mediates Zika virus entry, replication, and egress from host cells.
Heat shock protein 70 as a supplementary receptor facilitates enterovirus 71 infections in vitro.
Heat shock protein 70 from Litopenaeus vannamei (LvHSP70) is involved in the innate immune response against white spot syndrome virus (WSSV) infection.
Heat shock protein 70 from Trichinella spiralis induces protective immunity in BALB/c mice by activating dendritic cells.
Heat shock protein 70 is a potential virulence factor in murine toxoplasma infection via immunomodulation of host NF-kappa B and nitric oxide.
Heat Shock Protein 70 Messenger RNA in Rat Leukocytes Elevates After Severe Intestinal Ischemia-Reperfusion.
Heat shock protein 70 promotes coxsackievirus B3 translation initiation and elongation via Akt-mTORC1 pathway depending on activation of p70S6K and Cdc2.
Heat shock protein 72 (HSPA1B) gene polymorphism and Toll-like receptor (TLR) 4 mutation are associated with increased risk of urinary tract infection in children.
Heat shock protein 90 and heat shock protein 70 are components of dengue virus receptor complex in human cells.
Heat Shock Protein 90 Chaperones E1A Early Protein of Adenovirus 5 and Is Essential for Replication of the Virus.
Heat shock protein 90 localizes to the surface and augments virulence factors of Cryptococcus neoformans.
Heat Shock Protein 90 of Bonamia ostreae: Characterization and Possible Correlation with Infection of the Flat Oyster, Ostrea edulis.
Heat shock protein 90 positively regulates Chikungunya virus replication by stabilizing viral non-structural protein nsP2 during infection.
Heat Shock protein 90: Role in Enterovirus 71 Entry and Assembly and Potential Target for Therapy.
Heat Shock Protein A6, a Novel HSP70, Is Induced During Enterovirus A71 Infection to Facilitate Internal Ribosomal Entry Site-Mediated Translation.
Heat shock protein and heat shock factor 1 expression and localization in vaccinia virus infected human monocyte derived macrophages.
Heat shock protein expression and immunity in chlamydial infections.
Heat shock protein inhibitors increase the efficacy of measles virotherapy.
Heat Shock Protein Member 8 Is an Attachment Factor for Infectious Bronchitis Virus.
Heat shock protein profiles on the protein and gene expression levels in olive flounder kidney infected with Streptococcus parauberis.
Heat shock proteins (HSP 90, 70, 60, and 27) in Galleria mellonella (Lepidoptera) hemolymph are affected by infection with Conidiobolus coronatus (Entomophthorales).
Heat shock proteins protect platyfish (Xiphophorus maculatus) from Yersinia ruckeri induced mortality.
Heat-shock protein 60 and cardiovascular disease: a paradoxical role.
Heat-shock protein 90 promotes nuclear transport of herpes simplex virus 1 capsid protein by interacting with acetylated tubulin.
Heat-shock protein 90? is involved in maintaining the stability of VP16 and VP16-mediated transactivation of ? genes from herpes simplex virus-1.
Helicobacter pylori and cardiovascular disease: update 2019.
Helicobacter pylori and gastric epithelial cells: from gastritis to cancer.
Helicobacter pylori infection in connective tissue disorders is associated with high levels of antibodies to mycobacterial hsp65 but not to human hsp60.
Helicobacter pylori-derived heat shock protein 60 increases the induction of regulatory T-cells associated with persistent infection.
Hepatitis B and C virus-induced hepatitis: Apoptosis, autophagy, and unfolded protein response.
Hepatitis B virus enhances cisplatin-induced hepatotoxicity via a mechanism involving suppression of glucose-regulated protein of 78 Kda.
Herpes simplex virus Us11 protein enhances recovery of protein synthesis and survival in heat shock treated HeLa cells.
Herpes simplex virus-induced expression of 70 kDa heat shock protein (HSP70) requires early protein synthesis but not viral DNA replication.
HIF1A and NFAT5 coordinate Na+-boosted antibacterial defense via enhanced autophagy and autolysosomal targeting.
High affinity binding between Hsp70 and the C-terminal domain of the measles virus nucleoprotein requires an Hsp40 co-chaperone.
High doses of sodium ascorbate act as a prooxidant and protect gnotobiotic brine shrimp larvae (Artemia franciscana) against Vibrio harveyi infection coinciding with heat shock protein 70 activation.
High GRP78 levels in Covid-19 infection: A case-control study.
High-throughput screening fluorescence polarization assay for tumor-specific hsp90.
Host cell responses to Listeria monocytogenes infection include differential transcription of host stress genes involved in signal transduction.
Host factor heat-shock protein 90 contributes to baculovirus budded virus morphogenesis via facilitating nuclear actin polymerization.
Host protein, HSP90?, antagonizes IFN-? signaling pathway and facilitates the proliferation of encephalomyocarditis virus in vitro.
HPV genotypes distribution in Chlamydia trachomatis co-infection in a large cohort of women from North-East Italy.
Hsc70 Focus Formation at the Periphery of HSV-1 Transcription Sites Requires ICP27.
HSC70 interactions with SV40 viral proteins differ between permissive and nonpermissive mammalian cells.
Hsc70 is a Component of Bacterially Generated Actin-Rich Structures: An Immunolocalization Study.
HSC70 is required for infectious bursal disease virus (IBDV) infection in DF-1 cells.
Hsc70 regulates the IRES activity and serves as an antiviral target of enterovirus A71 infection.
Hsp27 Responds to and Facilitates Enterovirus A71 Replication by Enhancing Viral Internal Ribosome Entry Site-Mediated Translation.
HSP60 and anti-HSP60 antibodies in vasculitis: they are two of a kind.
HSP60 and HSP90? from blunt snout bream, Megalobrama amblycephala: Molecular cloning, characterization, and comparative response to intermittent thermal stress and Aeromonas hydrophila infection.
HSP60 critically regulates endogenous IL-1? production in activated microglia by stimulating NLRP3 inflammasome pathway.
Hsp60 specific antibodies in egg yolks from laying hens naturally infected with Salmonella enterica subspecies enterica serovar Enteritidis.
hsp70 and a novel axis of type I interferon-dependent antiviral immunity in the measles virus-infected brain.
HSP70 Overexpression in Response to Ureaplasma urealyticum-Mediated Oxidative Stress In Preeclamptic Placenta.
hsp70 synthesis in Schwann cells in response to heat shock and infection with Mycobacterium leprae.
Hsp70-1: upregulation via selective phosphorylation of heat shock factor 1 during coxsackieviral infection and promotion of viral replication via the AU-rich element.
hsp70-Dependent Antiviral Immunity against Cytopathic Neuronal Infection by Vesicular Stomatitis Virus.
HSP70/DNAJA3 chaperone/cochaperone regulates NF-?B activity in immune responses.
HSP90 and co-chaperones: a multitaskers' view on plant hormone biology.
Hsp90 function is required for stable transcription of the baculovirus transactivator ie-1 gene.
Hsp90 governs dispersion and drug resistance of fungal biofilms.
Hsp90 inhibitor AT-533 blocks HSV-1 nuclear egress and assembly.
Hsp90 inhibitor reduces porcine circovirus 2 replication in the porcine monocytic line 3D4/31.
Hsp90 Inhibitors Exhibit Resistance-Free Antiviral Activity against Respiratory Syncytial Virus.
Hsp90 inhibitors reduce influenza virus replication in cell culture.
Hsp90 inhibitors suppress HCV replication in replicon cells and humanized liver mice.
Hsp90 interacts with multiple dengue virus 2 proteins.
Hsp90 is essential in the filarial nematode Brugia pahangi.
Hsp90, Hsp60 and sHsp families of heat shock protein genes in channel catfish and their expression after bacterial infections.
Hsp90/Sec22b promotes unconventional secretion of mature-IL-1? through an autophagosomal carrier in porcine alveolar macrophages during Mycoplasma hyopneumoniae infection.
Hsp90: a chaperone for HIV-1.
Human antibody responses to Trypanosoma cruzi 70-kD heat-shock proteins.
Human Cytomegalovirus Stimulates Monocyte-to-Macrophage Differentiation via the Temporal Regulation of Caspase 3.
Human Heat shock protein 40 (Hsp40/DnaJB1) promotes influenza A virus replication by assisting nuclear import of viral ribonucleoproteins.
Human Hsp60: bacterial expression, purification, development of monoclonal antibodies and a sandwich ELISA for quantitation.
Human Metapneumovirus Impairs Apoptosis of Nasal Epithelial Cells in Asthma via HSP70.
Human T-cell clones to the 70-kilodalton heat shock protein of Mycobacterium leprae define mycobacterium-specific epitopes rather than shared epitopes.
Humoral immune response to conserved epitopes of Chlamydia trachomatis and human 60-kDa heat-shock protein in women with pelvic inflammatory disease.
ICP27 phosphorylation site mutants are defective in herpes simplex virus 1 replication and gene expression.
Identification and characterization of a DR4-restricted T cell epitope within chlamydia heat shock protein 60.
Identification of ?E-Dependent Promoter Upstream of clpB from the Pathogenic Spirochaete Leptospira interrogans by Applying an E. coli Two-Plasmid System.
Identification of autoantibodies with the corresponding antigen for repetitive coxsackievirus infection-induced cardiomyopathy.
Identification of Glucose-Regulated Protein 78 (GRP78) as a Receptor in BHK-21 Cells for Duck Tembusu Virus Infection.
Identification of GRP 78 (BiP) as a liver cell expressed receptor element for dengue virus serotype 2.
Identification of heat shock protein A9 as a Tembusu virus binding protein on DF-1 cells.
Identification of immunoreactive proteins of Chlamydia trachomatis by Western blot analysis of a two-dimensional electrophoresis map with patient sera.
Identification of in vivo-expressed immunogenic proteins by serological proteome analysis of the Bacillus anthracis secretome.
Identification of nontuberculous mycobacterial infection by IS6110 and hsp65 gene analysis on lung tissues.
Identification of rickettsial immunoreactive proteins using a proximity ligation assay Western blotting and the traditional immunoproteomic approach.
Identification of the resistance of a novel molecule heat shock protein 90alpha (HSP90alpha) in Microtus fortis to Schistosoma japonicum infection.
Identification of the small heat shock protein, HSP21, of shrimp Penaeus monodon and the gene expression of HSP21 is inactivated after white spot syndrome virus (WSSV) infection.
Identification of two mutation sites in spike and envelope proteins mediating optimal cellular infection of porcine epidemic diarrhea virus from different pathways.
Identification of Viral and Host Proteins That Interact with Murine Gammaherpesvirus 68 Latency-Associated Nuclear Antigen during Lytic Replication: a Role for Hsc70 in Viral Replication.
Immune recognition of human Hsp60 by Lyme disease patient sera.
Immune Recognition of the 60kD Heat Shock Protein: Implications for Subsequent Fertility.
Immune response against a cross-reactive epitope on the heat shock protein 60 homologue of Helicobacter pylori.
Immune response to heat shock protein of Helicobacter pylori--a candidate as a vaccine component.
Immune Responses Induced by HSP60 DNA Vaccine against Toxoplasma gondii Infection in Kunming Mice.
Immune Sensitization to the 60 kD Heat Shock Protein and Pregnancy Outcome.
Immunity against Yersinia enterocolitica by vaccination with Yersinia HSP60 immunostimulating complexes or Yersinia HSP60 plus interleukin-12.
Immunity to heat shock proteins and pregnancy outcome.
Immunization with Brugia malayi Hsp70 protects mice against Litomosoides sigmodontis challenge infection.
Immunization with plasmid DNA expressing Heat Shock Protein 40 confers prophylactic protection against chronic Toxoplasma gondii infection in Kunming mice.
Immunodetection of the recombinant GroEL by the Nanobody NbBruc02
Immunodetection of the recombinant GroEL by the Nanobody NbBruc02.
Immunogenicity and protective efficacy of GroEL (hsp60) of Streptococcus pneumoniae against lethal infection in mice.
Immunologic response enhances atherosclerosis-type 1 helper T cell (Th1)-to-type 2 helper T cell (Th2) shift and calcified atherosclerosis in Bacillus Calmette-Guerin (BCG)-treated apolipoprotein E-knockout (apo E-/-) mice.
Immunovirotherapy with measles virus strains in combination with anti-PD-1 antibody blockade enhances antitumor activity in glioblastoma treatment.
Impaired inducibility of heat shock protein 70 in peripheral blood lymphocytes of patients with severe sepsis.
Implication of heat shock proteins in rotavirus entry into Reh cells.
Implication of Hsc70, PDI and integrin ?v?3 involvement during entry of the murine rotavirus ECwt into small-intestinal villi of suckling mice.
Implications of antibodies to heat-shock proteins in ischemic heart disease.
Improvement of the production of GFPuv-beta1,3-N-acetylglucosaminyltransferase 2 fusion protein using a molecular chaperone-assisted insect-cell-based expression system.
In silico analysis of proteins and microRNAs related to human African trypanosomiasis in tsetse fly.
In silico identification of functional divergence between the multiple groEL gene paralogs in Chlamydiae.
In vitro interactions between 17-AAG and azoles against Exophiala dermatitidis.
In vivo and in vitro association of hsc70 with polyomavirus capsid proteins.
Increase in a heat-shock protein from blood cells in response of nestling house martins (Delichon urbica) to parasitism: an experimental approach.
Increased expression of 70 kD heat shock protein in cultured primary human keratinocytes induced by human papillomavirus 16 E6/E7 gene.
Increased expression of Gp96 by HBx-induced NF-?B activation feedback enhances hepatitis B virus production.
Increased expression of HDJ-2 (heat shock protein 40) and heat shock protein 70 in biopsy specimens of transplanted human lungs.
Increased intracellular, cell surface, and secreted inducible heat shock protein 70 responses are triggered during the monocyte to dendritic cell (DC) transition by cytokines independently of heat stress and infection and may positively regulate DC growth.
Increased risk of atherosclerosis is confined to CagA-positive Helicobacter pylori strains: prospective results from the Bruneck study.
Induction of cellular hsp70 expression by human cytomegalovirus.
Induction of heat shock protein 60 expression in human monocytic cell lines infected with Mycobacterium leprae.
Induction of heat shock protein closely correlates with protection against Toxoplasma gondii infection.
Induction of manganese-superoxide dismutase in MRC-5 cells persistently infected with an alphavirus, sindbis.
Induction of messenger RNA for the 70 kDa heat shock protein in HeLa cells and the human endocervix following exposure to semen: implications for antisperm antibody production and susceptibility to sexually transmitted infections.
Induction of oral tolerance as treatment or prevention of chronic diseases associated with Chlamydia pneumoniae infection--hypothesis.
Induction of pro-viral grass carp Ctenopharyngodon idella Hsp70 instead of Hsc70 during infection of grass carp reovirus.
Induction of secretion of interleukin-8 from human gastric epithelial cells by heat-shock protein 60 homologue of Helicobacter pylori.
Induction of SIV capsid-specific CTL and mucosal sIgA in mice immunized with a recombinant S. typhimurium aroA mutant.
Infection by ME7 prion is not modified in transgenic mice expressing the yeast chaperone Hsp104 in neurons.
Infection of human and murine macrophages with Leishmania major is associated with early parasite heat shock protein synthesis but fails to induce a host cell stress response.
Inflammation, heat shock proteins and periodontal pathogens in atherosclerosis: an immunohistologic study.
Influence of parasitization by Trichinella spiralis on the levels of heat shock proteins in rat liver and muscle.
Influenza A virus nucleoprotein exploits Hsp40 to inhibit PKR activation.
Ingestion of bacteria overproducing DnaK attenuates Vibrio infection of Artemia franciscana larvae.
Inhibition of Calpain Alleviates Apoptosis in Coxsackievirus B3-induced Acute Virus Myocarditis Through Suppressing Endoplasmic Reticulum Stress.
Inhibition of heat-shock protein 90 enhances the susceptibility to antifungals and reduces the virulence of Cryptococcus neoformans/Cryptococcus gattii species complex.
Inhibition of heat-shock protein 90 reduces Ebola virus replication.
Inhibition of HSP90 and Activation of HSF1 Diminish Macrophage NLRP3 Inflammasome Activity in Alcohol-Associated Liver Injury.
Inhibition of HSP90 attenuates porcine reproductive and respiratory syndrome virus production in vitro.
Inhibition of infectious bursal disease virus infection by artificial miRNAs targeting the chicken heat shock protein 90.
Inhibition of rotavirus ECwt infection in ICR suckling mice by N-acetylcysteine, peroxisome proliferator-activated receptor gamma agonists and cyclooxygenase-2 inhibitors.
Inhibitory effect of Japanese rice-koji miso extracts on hepatitis A virus replication in association with the elevation of glucose-regulated protein 78 expression.
Initiation of the Immune Response by Extracellular Hsp72: Chaperokine Activity of Hsp72.
Innate immune gene expression in individual zebrafish after Listonella anguillarum inoculation.
Insights into Macrophage Autophagy in Latent Tuberculosis Infection: Role of Heat Shock Protein 16.3.
Interactive Responses of Potato (Solanum tuberosum L.) Plants to Heat Stress and Infection With Potato Virus Y.
Intra- and inter-breed variation in immune response to acute and sub-chronic Salmonella infection and commercial immune-stimulant in two-layer breeds.
Involvement of HSC70-4 and other inducible HSPs in Bombyx mori nucleopolyhedrovirus infection.
Irreversible UV inactivation of Cryptosporidium spp. despite the presence of UV repair genes.
Is chlamydial heat shock protein 60 a risk factor for oncogenesis?
Isolation and characterization of Heat Shock Protein 100-Batu1 from Toxoplasma gondii RH strain.
Kinase suppressor of Ras-1 protects against pulmonary Pseudomonas aeruginosa infections.
Lack of association between the GRP78 polymorphisms in the promoter and 3' UTR and susceptibility to chronic HBV infection in a Chinese Han population.
LAP, an alcohol acetaldehyde dehydrogenase enzyme in Listeria, promotes bacterial adhesion to enterocyte-like Caco-2 cells only in pathogenic species.
Larvae Crowding Increases Development Rate, Improves Disease Resistance, and Induces Expression of Antioxidant Enzymes and Heat Shock Proteins in Mythimna separata (Lepidoptera: Noetuidae).
Leishmania major Hsp100 is required chiefly in the mammalian stage of the parasite.
Lipid raft microdomains: key sites for Coxsackievirus A9 infectious cycle.
Listeria monocytogenes Uses LAP to Promote Bacterial Transepithelial Translocation, and Induces Expression of LAP Receptor Hsp60.
Localization of sweet potato chlorotic stunt virus (SPCSV) in synergic infection with potyviruses in sweet potato.
M. paratuberculosis Heat Shock Protein 65 and Human Diseases: Bridging Infection and Autoimmunity.
Mapping of a visceral leishmaniasis-specific immunodominant B-cell epitope of Leishmania donovani Hsp70.
mda-7 (IL-24) Mediates selective apoptosis in human melanoma cells by inducing the coordinated overexpression of the GADD family of genes by means of p38 MAPK.
Mechanisms of HSP65 expression induced by gamma delta T cells in murine Toxoplasma gondii infection.
Middle East respiratory syndrome coronavirus and bat coronavirus HKU9 both can utilize GRP78 for attachment onto host cells.
miR-382-5p promotes porcine reproductive and respiratory syndrome virus (PRRSV) replication by negatively regulating the induction of type I interferon.
Mitochondrial distribution and function in herpes simplex virus-infected cells.
Mitochondrial Heat Shock Response Induced by Ectromelia Virus is Accompanied by Reduced Apoptotic Potential in Murine L929 Fibroblasts.
Mitochondrial peroxiredoxin functions as crucial chaperone reservoir in Leishmania infantum.
Modulated heat shock protein expression during pathogenic Vibrio alginolyticus stress of sea bream.
Modulation of adjuvant arthritis in Lewis rats by recombinant vaccinia virus expressing the human 60-kilodalton heat shock protein.
Modulation of endothelial cell damages by anti-Hsp60 autoantibodies in systemic autoimmune diseases.
Modulation of herpes simplex virus (HSV) infection of cultured neuronal cells by nerve growth factor and antibody to HSV.
Modulation of Hsp60 in response to coral brown band disease.
Modulation of macrophage heat shock proteins (HSPs) expression in response to intracellular infection by virulent and avirulent strains of Leishmania donovani.
Modulation of stress protein (hsp27 and hsp70) expression in CD4+ lymphocytic cells following acute infection with human immunodeficiency virus type-1.
Modulation of the unfolded protein response pathway as an antiviral approach in airway epithelial cells.
Molecular and immunological characterisation of the glucose regulated protein 78 of Leishmania donovani(1).
Molecular chaperones and the immune response.
Molecular characterization and expression analysis of Hsp90 in Schizothorax prenanti.
Molecular characterization of heat shock protein 70 gene transcripts during Vibrio harveyi infection of humphead snapper, Lutjanus sanguineus.
Molecular cloning and characterization of groESL operon in Streptococcus pneumoniae.
Molecular cloning and expression analysis of five heat shock protein 70 (HSP70) family members in Lateolabrax maculatus with Vibrio harveyi infection.
Molecular cloning of Ra-sHSPI, a novel member of the HSP20 family from Rhipicephalus annulatus salivary glands.
Molecular cloning, characterization and expression analysis of heat shock protein 90 in albino northern snakehead Channa argus.
Molecular diagnosis of fatal Nocardia farcinica pneumonia in an HIV-negative patient.
Monoclonal antibodies to heat shock protein 60 induce a protective immune response against experimental Paracoccidioides lutzii.
Mortalin restricts porcine epidemic diarrhea virus entry by downregulating clathrin-mediated endocytosis.
Multiple Chlamydiaceae species in trachoma: implications for disease pathogenesis and control.
Multiple Herpes Simplex Virus-1 (HSV-1) Reactivations Induce Protein Oxidative Damage in Mouse Brain: Novel Mechanisms for Alzheimer's Disease Progression.
Mycobacterial 65-kilodalton heat shock protein induces tumor necrosis factor alpha and interleukin 6, reactive nitrogen intermediates, and toxoplasmastatic activity in murine peritoneal macrophages.
Mycoplasma hyopneumoniae Inhibits Porcine Beta-Defensin 2 Production by Blocking the Unfolded Protein Response To Facilitate Epithelial Adhesion and Infection.
Nest ectoparasites increase physiological stress in breeding birds: an experiment.
Neuroprotection by Hsp104 and Hsp27 in lentiviral-based rat models of Huntington's disease.
NLRP3 inflammasome activation in aged macrophages is diminished during Streptococcus pneumoniae infection.
Non-Structural Protein 2B of Human Rhinovirus 16 Activates Both PERK and ATF6 Rather Than IRE1 to Trigger ER Stress.
Novel Prophylactic Vaccine Using a Prime-Boost Method and Hemagglutinating Virus of Japan-Envelope against Tuberculosis.
Novel vaccines for the treatment of chronic HBV infection based on mycobacterial heat shock protein 70.
Nuclear transport of Epstein-Barr virus DNA polymerase is dependent on the BMRF1 polymerase processivity factor and molecular chaperone Hsp90.
Nucleopolyhedroviruses (NPV) induce the expression of small heat shock protein 25.4 in Antheraea pernyi.
Oligomerization of ICP4 and rearrangement of heat shock proteins may be important for herpes simplex virus type 1 prereplicative site formation.
Oral Immunization with a Multivalent Epitope-Based Vaccine, Based on NAP, Urease, HSP60, and HpaA, Provides Therapeutic Effect on H. pylori Infection in Mongolian gerbils.
Oral Tolerance Induced by Heat Shock Protein 65-Producing Lactococcus lactis Mitigates Inflammation in Leishmania braziliensis Infection.
Over-expression of Saccharomyces cerevisiae hsp90 enhances the virulence of this yeast in mice.
Overexpression of PLK3 Mediates the Degradation of Abnormal Prion Proteins Dependent on Chaperone-Mediated Autophagy.
Passive immunization with a monoclonal IgM antibody specific for Strongyloides ratti HSP60 protects mice against challenge infection.
Pathogenic infection and immune-related gene expression of Chinese sturgeon (Acipenser sinensis) challenged by Citrobacter freundii.
Peptidyl-prolyl cis-trans isomerases, a superfamily of ubiquitous folding catalysts.
Performance of multiplex serology in discriminating active vs past Helicobacter pylori infection in a primarily African American population in the southeastern United States.
Peripheral blood mononuclear cell responses to heat shock proteins in patients undergoing stem cell transplantation.
Persistence of Chlamydia pneumoniae in degenerative aortic valve stenosis indicated by heat shock protein 60 homologues.
Phase I dose-escalation study of a monovalent heat shock protein 70-herpes simplex virus type 2 (HSV-2) peptide-based vaccine designed to prime or boost CD8 T-cell responses in HSV-naïve and HSV-2-infected subjects.
Phloroglucinol-Mediated Hsp70 Production in Crustaceans: Protection against Vibrio parahaemolyticus in Artemia franciscana and Macrobrachium rosenbergii.
Plasma membrane expression of heat shock protein 60 in vivo in response to infection.
Pollution-induced heat shock protein expression in the amphipod Gammarus roeseli is affected by larvae of Polymorphus minutus (Acanthocephala).
Polyclonal expansion of peripheral gamma delta T cells in human Plasmodium falciparum malaria.
Polymorphism of Immune Response Genes as a Factor for Predisposition to Development of Diseases.
Polymorphisms of heat shock protein-70 (hspa1b and hspa1l Loci) do not influence infection or outcome risk in critically ill surgical patients.
Porcine epidemic diarrhea virus infections induce autophagy in Vero cells via ROS-dependent endoplasmic reticulum stress through PERK and IRE1 pathways.
Porphyromonas gingivalis heat shock protein vaccine reduces the alveolar bone loss induced by multiple periodontopathogenic bacteria.
Porphyromonas gingivalis HSP60 peptides have distinct roles in the development of atherosclerosis.
Preparation of apoptotic tumor cells with replication-incompetent HSV augments the efficacy of dendritic cell vaccines.
Prevalence of Anaplasma and Bartonella spp. in Ticks Collected from Korean Water Deer (Hydropotes inermis argyropus).
Previously undetected Chlamydia trachomatis infection, immunity to heat shock proteins and tubal occlusion in women undergoing in-vitro fertilization.
Prior immunity to Trichinella spiralis prevents (re)occurrence of an explicit stress response in intestines but not in mesenteric lymph nodes, heart and lungs from reinfected rats.
Probing the heat shock response of Corynebacterium pseudotuberculosis: the major virulence factor, phospholipase D, is downregulated at 43 degrees C.
Production of Chlamydia pneumoniae proteins in Bacillus subtilis and their use in characterizing immune responses in the experimental infection model.
Production of stress-inducible form of heat-shock protein 70 in mouse peritoneal adherent cells after in vivo infection by Francisella tularensis.
Progress and prospects for targeting Hsp90 to treat fungal infections.
Proposing BCG Vaccination for Mycobacterium avium ss. paratuberculosis (MAP) Associated Autoimmune Diseases.
Protein folding studies in vivo with a bacteriophage T4 expression-packaging-processing vector that delivers encapsidated fusion proteins into bacteria.
Proteomic analysis of differentially expressed proteins in Fenneropenaeus chinensis hemocytes upon white spot syndrome virus infection.
Pulmonary necrosis resulting from DNA vaccination against tuberculosis.
Quantitative proteomic analyses of human cytomegalovirus-induced restructuring of endoplasmic reticulum-mitochondrial contacts at late times of infection.
Quantitative proteomics analysis provides insight into the biological role of Hsp90 in BmNPV infection in Bombyx mori.
Quantitative whole-cell proteome analysis of pseudorabies virus-infected cells.
Rabies viruses leader RNA interacts with host Hsc70 and inhibits virus replication.
Real-time quantitative polymerase chain reaction (QPCR) to identify Myxobolus cerebralis in rainbow trout Oncorhynchus mykiss.
Reciprocal regulation of human immunodeficiency virus-1 gene expression and replication by heat shock proteins 40 and 70.
Recombinant heat shock protein 78 enhances enterovirus 71 propagation in Vero cells and is induced in SK-N-SH cells during the infection.
Recombinant protein and DNA vaccines derived from hsp60 Trichophyton mentagrophytes control the clinical course of trichophytosis in bovine species and guinea-pigs.
Redox regulation of mammalian heat shock factor 1 is essential for Hsp gene activation and protection from stress.
Reduced levels of gamma-interferon secretion in response to chlamydial 60 kDa heat shock protein amongst women with pelvic inflammatory disease and a history of repeated Chlamydia trachomatis infections.
Regulation of an adaptor protein STING by Hsp90? to enhance innate immune responses against microbial infections.
Regulation of iNOS-Derived ROS Generation by HSP90 and Cav-1 in Porcine Reproductive and Respiratory Syndrome Virus-Infected Swine Lung Injury.
Regulation of Molecular Chaperone GRP78 by Hepatitis B Virus: Control of Viral Replication and Cell Survival.
Regulation of Toll-like receptor 2 interaction with Ecgp96 controls Escherichia coli K1 invasion of brain endothelial cells.
Regulation of Viral Replication, Apoptosis and Pro-Inflammatory Responses by 17-AAG during Chikungunya Virus Infection in Macrophages.
Relationship between Helicobacter pylori, gastric parietal cell antibodies and heat shock proteins.
Relative increase in IgG antibodies to Pseudomonas aeruginosa 60-kDa GroEL in prediabetic patients with cystic fibrosis.
Remodeling of the Histoplasma Capsulatum Membrane Induced by Monoclonal Antibodies.
Reprogramming the unfolded protein response for replication by porcine reproductive and respiratory syndrome virus.
Reversal of Schistosome Resistance In Biomphalaria glabrata By Heat Shock May Be Dependent On Snail Genotype.
Role of chlamydial heat shock protein 60 in the stimulation of innate immune cells by Chlamydia pneumoniae.
Role of Heat-Shock Protein (HSP) 70-2 Genotype in Peptic Ulcer in Japanese Population.
Role of immune responses to a GroEL heat shock protein in preventing brucellosis in mice vaccinated with Brucella abortus strain RB51.
Role of innate immune cells in protection against Toxoplasma gondii at inflamed site.
Roles of NKT cells in resistance against infection with Toxoplasma gondii and in expression of heat shock protein 65 in the host macrophages.
Roles of Toxoplasma gondii-derived heat shock protein 70 in host defense against T. gondii infection.
Selection of maize inbred lines and gene expression for resistance to ear rot.
Selective induction of chromosomal gene expression by human cytomegalovirus.
Semi-nested PCR detection of Bartonella henselae in Ixodes persulcatus ticks from Western Siberia, Russia.
Sendai virus pneumonia: evidence for the early recruitment of gamma delta T cells during the disease course.
Serological association between Chlamydia pneumoniae infection and age-related macular degeneration.
Serological Testing for Mycobacterial Heat Shock Protein Hsp65 Antibody in Health and Diseases.
Serum antibody response to the heat shock protein 60 of Chlamydia trachomatis in women with developing cervical cancer.
Serum biomarkers differentiating Kawasaki disease from febrile infections: A pilot case-control study.
Serum immunoglobulin G antibodies to chlamydial heat shock protein 60 but not to human and bacterial homologs are associated with coronary artery disease.
SGTA-dependent regulation of Hsc70 promotes cytosol entry of SV40 from the ER.
Shock response induced in rat brain and spleen during primary infection with Trichinella spiralis larvae.
Single dose of a vaccine based on DNA encoding mycobacterial hsp65 protein plus TDM-loaded PLGA microspheres protects mice against a virulent strain of Mycobacterium tuberculosis.
Small heat-shock proteins: important players in regulating cellular proteostasis.
Small molecular compounds that inhibit hepatitis C virus replication through destabilizing heat shock cognate 70 messenger RNA.
Spatial and Temporal Resolution of Global Protein Synthesis during HSV Infection Using Bioorthogonal Precursors and Click Chemistry.
Streptococcus pneumoniae heat shock protein 70 does not induce human antibody responses during infection.
Structure and regulation of the HSP90 gene from the pathogenic fungus Candida albicans.
Study on the cloning, expression and the immunogenicity of helicobacter pylori heat shock protein 60 gene.
Study on the immune response to recombinant Hsp70 protein from Megalobrama amblycephala.
Subcellular localization of the 65-kDa heat shock protein in mycobacteria by immunoblotting and immunogold ultracytochemistry.
Subcellular Location of Piscirickettsia salmonis Heat Shock Protein 60 (Hsp60) Chaperone by Using Immunogold Labeling and Proteomic Analysis.
Surface localized Heat Shock Protein 20 (HslV) of Helicobacter pylori.
Surface-associated Hsp60 chaperonin of Leptospira interrogans serovar Autumnalis N2 strain as an immunoreactive protein.
Survey of molecular chaperone requirement for the biosynthesis of hamster polyomavirus VP1 protein in Saccharomyces cerevisiae.
Susceptibility of heat shock protein 70.1-deficient C57BL/6 J, wild-type C57BL/6 J and A/J mice to Trypanosoma congolense infection.
Susceptibility of human monocyte-macrophages to Chlamydia pneumoniae infection in vitro is highly variable and associated with levels of soluble CD14 and C. pneumoniae IgA and human HSP-IgG antibodies in serum.
Systemic and mucosal immunization with Candida albicans hsp90 elicits hsp90-specific humoral response in vaginal mucosa which is further enhanced during experimental vaginal candidiasis.
T-cell recognition of mycobacterial GroES peptides in Thai leprosy patients and contacts.
T-cell, antibody, and cytokine responses to homologs of the 60-kilodalton heat shock protein in Helicobacter pylori infection.
Tandem Mass Tag-Based Quantitative Proteomic Analysis of Chicken Bursa of Fabricius Infected With Reticuloendotheliosis Virus.
Targeted induction of antigen expression within dendritic cells modulates antigen-specific immunity afforded by recombinant BCG.
Targeting the Kingella Kingae groEL Gene is a Reliable Method for the Molecular Diagnosis of K. Kingae Infection and Carriage.
The 72K IE1 and 80K IE2 proteins of human cytomegalovirus independently trans-activate the c-fos, c-myc and hsp70 promoters via basal promoter elements.
The adverse events of haematopoietic stem cell transplantation are associated with gene polymorphism within human leukocyte antigen region.
The Cellular Chaperone Heat Shock Protein 90 Is Required for Foot-and-Mouth Disease Virus Capsid Precursor Processing and Assembly of Capsid Pentamers.
The cellular inhibitor of the PKR protein kinase, P58(IPK), is an influenza virus-activated co-chaperone that modulates heat shock protein 70 activity.
The cellular stress response of the scleractinian coral Goniopora columna during the progression of the black band disease.
The chaperone GRP78 is a host auxiliary factor for SARS-CoV-2 and GRP78 depleting antibody blocks viral entry and infection.
The characteristics of the expression of heat shock proteins and COX-2 in the liver of hamsters infected with Clonorchis sinensis, and the change of endocrine hormones and cytokines.
The clonal antibody response to Pseudomonas aeruginosa heat shock protein is highly diverse in cystic fibrosis patients.
The co-chaperone Cdc37 regulates the rabies virus phosphoprotein stability by targeting to Hsp90AA1 machinery.
The curli biogenesis genes expression level is unassociated with Enterobacter cloacae hsp60 clusters and PFGE genotypes.
The dynamics of heat shock system activation in Monomac-6 cells upon Helicobacter pylori infection.
The E1A 13S product of adenovirus 5 activates transcription of the cellular human HSP70 gene.
The endosymbiotic bacterium Holospora obtusa enhances heat-shock gene expression of the host Paramecium caudatum.
The Escherichia coli chaperonin 60 (groEL) is a potent stimulator of osteoclast formation.
The Heat Shock Protein 70 Family of Chaperones Regulates All Phases of the Enterovirus A71 Life Cycle.
The heat shock protein 90 of Eimeria tenella is essential for invasion of host cell and schizont growth.
The Heat-Induced Molecular Disaggregase Hsp104 of Candida albicans Plays a Role in Biofilm Formation and Pathogenicity in a Worm Infection Model.
The Herpes Simplex Virus 1 Immediate Early Protein ICP22 Is a Functional Mimic of a Cellular J Protein.
The hsc70 gene which is slightly induced by heat is the main virus inducible member of the hsp70 gene family.
The Hsp90 inhibitor 17-DMAG decreases infection of porcine circovirus type 2 in mice.
The Hsp90 of Candida albicans can confer Hsp90 functions in Saccharomyces cerevisiae: a potential model for the processes that generate immunogenic fragments of this molecular chaperone in C. albicans infections.
The induction of stromule formation by a plant DNA-virus in epidermal leaf tissues suggests a novel intra- and intercellular macromolecular trafficking route.
The interaction of white spot syndrome virus envelope protein VP28 with shrimp Hsc70 is specific and ATP-dependent.
The measles virus (MV) glycoproteins interact with cellular chaperones in the endoplasmic reticulum and MV infection upregulates chaperone expression.
The mechanism of heat-shock protein 70 gene expression abolition in gastric epithelium caused by Helicobacter pylori infection.
The Molecular Mechanism of Hemocyte Immune Response in Marsupenaeus japonicus Infected With Decapod Iridescent Virus 1.
The multi-drug efflux system AcrABZ-TolC is essential for infection of Salmonella Typhimurium by the flagellum-dependent bacteriophage Chi.
The mycobacterial GroEL stress protein: a common target of T-cell recognition in infection and autoimmunity.
The N terminus of the head protein of T4 bacteriophage directs proteins to the GroEL chaperonin.
The Noncanonical Heat Shock Protein PvNod22 Is Essential for Infection Thread Progression During Rhizobial Endosymbiosis in Common Bean.
The NS5A-binding heat shock proteins HSC70 and HSP70 play distinct roles in the hepatitis C viral life cycle.
The outcome of poliovirus infections in K562 cells is cytolytic rather than persistent after hemin-induced differentiation.
The Peptide-Binding and ATPase Domains of Recombinant hsc70 Are Required To Interact with Rotavirus and Reduce Its Infectivity.
The Plasmodium translocon of exported proteins component EXP2 is critical for establishing a patent malaria infection in mice.
The promoter polymorphism of the IL-6 gene is associated with levels of antibodies to 60-kDa heat-shock proteins.
The Pseudomonas aeruginosa HSP90-like protein HtpG regulates IL-8 expression through NF-?B/p38 MAPK and CYLD signaling triggered by TLR4 and CD91.
The role of heat shock protein 70 in resistance to Salmonella enteritidis in broiler chickens subjected to neonatal feed restriction and thermal stress.
The role of Heat Shock Protein 90 (HSP90) in Hepatitis E Virus (HEV) Capsid Trafficking.
The role of heat shock proteins in atherosclerosis.
The Role of Heat Shock Proteins in Leukemia.
The role of hsp90 in fungal infection.
The Role of Prostate Apoptosis Response-4 (Par-4) in Mycobacterium tuberculosis Infected Macrophages.
The role of the infectious agents in the pathogenesis and evolution of atherosclerosis.
Theiler's murine encephalomyelitis virus infection induces a redistribution of heat shock proteins 70 and 90 in BHK-21 cells, and is inhibited by novobiocin and geldanamycin.
Tick-borne encephalitis virus triggers inositol-requiring enzyme 1 (IRE1) and transcription factor 6 (ATF6) pathways of unfolded protein response.
Time-Resolved Proteome Analysis of Listeria monocytogenes during Infection Reveals the Role of the AAA+ Chaperone ClpC for Host Cell Adaptation.
Tobamovirus infection is independent of HSP101 mRNA induction and protein expression.
Tolerization against atherosclerosis using heat shock protein 60.
Toll-like receptor 4-mediated respiratory syncytial virus disease and lung transcriptomics in differentially susceptible inbred mouse strains.
Tomato plant cell death induced by inhibition of HSP90 is alleviated by Tomato yellow leaf curl virus infection.
Transcriptional analysis of Rickettsia prowazekii invasion gene homolog (invA) during host cell infection.
Transcriptome Analysis Reveals Unfolded Protein Response Was Induced During the Early Stage of Burkholderia pseudomallei Infection in A549 Cells.
Transcriptomic profiling of SARS-CoV-2 infected human cell lines identifies HSP90 as target for COVID-19 therapy.
TRIM5alpha association with cytoplasmic bodies is not required for antiretroviral activity.
Ts-Hsp70 induces protective immunity against Trichinella spiralis infection in mouse by activating dendritic cells through TLR2 and TLR4.
Two putative protein export regulators promote malaria blood stage development in vivo.
Two routes of infection with Photobacterium damselae subsp. piscicida are effective in the modulation of the transcription of immune related genes in Solea senegalensis.
Tyrosine phosphorylation modulates mitochondrial chaperonin Hsp60 and delays rotavirus NSP4-mediated apoptotic signaling in host cells.
Unsuspected Chlamydia trachomatis infection and in vitro fertilization outcome.
Up-regulation of Hsp60 in response to skeleton eroding band disease but not by algal overgrowth in the scleractinian coral Acropora muricata.
Urine heat shock protein 70 levels as a marker of urinary tract infection in children.
Use of immunological methods to the detection of toxoplasmosis and heat shock protein HSP70 in men.
Vaccinia virus infection induces a stress response that leads to association of Hsp70 with viral proteins.
VceC Mediated IRE1 Pathway and Inhibited CHOP-induced Apoptosis to Support Brucella Replication in Goat Trophoblast Cells.
VEGF(165) promotes survival of leukemic cells by Hsp90-mediated induction of Bcl-2 expression and apoptosis inhibition.
Virulence factor RNA transcript expression in the Leishmania Viannia subgenus: influence of species, isolate source, and Leishmania RNA virus-1.
Virus-Induced Chaperone-Enriched (VICE) domains function as nuclear protein quality control centers during HSV-1 infection.
Voltage dependent anion channel is redistributed during Japanese encephalitis virus infection of insect cells.
VP1-binding protein glucose-regulated protein 78 as an important mediator for enterovirus 71 infecting human brain microvascular endothelial cells.
VP1-Binding Protein Glucose-regulated protein 78 as an important mediator for Enterovirus 71 infecting Human Brain Microvascular Endothelial Cells.
Whole-genome sequencing provides new insights into genetic mechanisms of tropical adaptation in Nellore (Bos primigenius indicus).
[ANTI-Hsp60 ANTIBODIES IN ARTERIAL HYPERTENTION DIFERENT DEGREE OF SEVERITY].
[Behaviour of gamma delta TCR+ T cells during the course of nontuberculous mycobacterial infections and proliferative response of host lymphocytes to 65kD heat shock protein]
[Chlamydia pneumoniae and cytomegalovirus in degenerative aortic valve stenoses]
[Chlamydial heat shock protein (hsp 60) and fertility disorders]
[Detection of serum heat shock protein 70 level in patients with hepatitis C infection and its role in cytotoxicity of CTLs induced by HSP70-HCV peptide complex]
[Effect of heat shock protein 70 on nuclear factor-KappaB/inhibitor protein-alpha of nuclear factor-KappaB in brain edema induced by infection in rat]
[Effect of total flavonoids of astragalus on endoplasmic reticulum chaperone, calumenin and connecxin 43 in suckling mouse myocardium with myocarditis caused by coxsackievirus B3].
[Evidence of antibodies against the chlamydial heat shock protein (cHSP60) in women from "in vitro" fertilization program]
[Examination of possible role of the chlamydial stress proteins in pathogenesis of ectopic pregnancy].
[Possible roles of infections and heat shock proteins in rheumatoid arthritis]
[Protective effects of co-immunization with SjCTPI-Hsp70 and interleukin-12 DNA vaccines against Schistosoma japonicum challenge infection in water buffalo]
[Rapid detection and identification of mycobacteria by the PCR assay based on the co-amplification of the gene IS6110 and groEL]
[Relationship between Pi-Wei damp-heat syndrome with expressions of nuclear factor-kappaBmRNA and heat shock protein 70 mRNA in patients with chronic gastritis]
[Role of chronic infection and heat shock proteins in peripheral arterial disease]
[Roles of transforming growth factor - ?1 and heat shock protein 47 in progression of Schistosoma japonicum-induced hepatic fibrosis].
[Significance of heat shock protein 70 in cerebrospinal fluid in differential diagnosis of central nervous system infection in children]
[The effect of astragalus injection on the expression of endoplasmic reticulum stress chaperonin GRP78 and GRP94 mRNA in adriamycin-injured cardiomyocytes with calumenin silencing by shRNA].
[The relationship between miRNA378, calumenin and endoplasmic reticulum stress in suckling mouse myocardium with myocarditis caused by adriamycin].
[Thoughts on pathogenesis of Helicobacter pylori related gastrosis with splenogastric hygropyrexia syndrome]
[Validity of the Morawietz classification for evaluation of periprosthetic tissue].
Infertility
A block in the road to fertility: autoantibodies to heat-shock protein 90-beta in human ovarian autoimmunity.
A PROSPECTIVE STUDY TO ANALYZE THE SPECIFICITY OF CHLAMYDIAL HEAT SHOCK PROTEIN (CHSP60) ANTIBODIES TO DIAGNOSE TUBAL INFERTILITY.
Antibodies to Chlamydia trachomatis heat shock proteins Hsp60 and Hsp10 and subfertility in general population at age 31.
Antibodies to the chlamydial 60 kilodalton heat shock protein in women with tubal factor infertility.
Association of uterine and salpingeal fibrosis with chlamydial hsp60 and hsp10 antigen-specific antibodies in Chlamydia-infected koalas.
Cell-mediated immunity to human and Escherichia coli 60-kDa heat shock protein in women: association with a history of spontaneous abortion and endometriosis.
Chlamydia infection and subfertility.
Chlamydia trachomatis and chlamydial heat shock protein 60-specific antibody and cell-mediated responses predict tubal factor infertility.
Chlamydia trachomatis heat shock protein-60 induced interferon-gamma and interleukin-10 production in infertile women.
Chlamydia trachomatis Infection, Immunity, and Pregnancy Outcome.
Circulating antibodies to a conserved epitope of the Chlamydia trachomatis 60 kDa heat shock protein (hsp60) in infertile couples and its relationship to antibodies to C.trachomatis surface antigens and the Escherichia coli and human HSP60.
Combining individual Chlamydia trachomatis IgG antibodies MOMP, TARP, CPAF, OMP2, and HSP60 for tubal factor infertility prediction.
Effects of KH-204 on the expression of heat shock protein 70 and germ cell apoptosis in infertility rat models.
Expression of heat shock protein 70 kDa in human endometrium of normal and infertile women.
Expression of the 60 kDa heat shock protein in peritoneal fluids from women with endometriosis: implications for endometriosis-associated infertility.
Genome-wide dissection of AP2/ERF and HSP90 gene families in five legumes and expression profiles in chickpea and pigeonpea.
Hsp60 expression and localization in different tissues and testis development of male cattle (cattle-yak and yak).
Humoral immune response to the chlamydial heat shock proteins hsp60 and hsp70 in Chlamydia-associated chronic salpingitis with tubal occlusion.
Immune Recognition of the 60kD Heat Shock Protein: Implications for Subsequent Fertility.
Immunopathogenesis of chlamydia trachomatis infections in women.
Induction of infertility by the Chlamydia trachomatis mouse pneumonitis biovar in strains of mice that differ in their response to the 60 kDa heat shock protein.
Infertility following pelvic inflammatory disease.
Levels of oestrogen receptor, progesterone receptor and ?B-crystallin in eutopic endometrium in relation to pregnancy in women with endometriosis.
Male immunity to the chlamydial 60 kDa heat shock protein (HSP 60) - associated with semen quality?
Members of the 70 kDa heat shock protein family specifically recognize sulfoglycolipids: role in gamete recognition and mycoplasma-related infertility.
Microbiota-based analysis reveals specific bacterial traits and a novel strategy for the diagnosis of infectious infertility.
Mycobacterial heat shock protein 65 mediated metabolic shift in decidualization of human endometrial stromal cells.
Persistent Chlamydia trachomatis infections resist apoptotic stimuli.
Reduced levels of gamma-interferon secretion in response to chlamydial 60 kDa heat shock protein amongst women with pelvic inflammatory disease and a history of repeated Chlamydia trachomatis infections.
Regulation by Hsp27/P53 in testis development and sperm apoptosis of male cattle (cattle-yak and yak).
Roles of Grp78 in Female Mammalian Reproduction.
Serologic responses of infertile women to the 60-kd chlamydial heat shock protein (hsp60).
Seroreactivity to Chlamydia trachomatis Hsp10 correlates with severity of human genital tract disease.
Single nucleotide polymorphisms of the heat shock protein 90 gene in varicocele-associated infertility.
Sub-fertility in crossbred bulls: Identification of proteomic alterations in spermatogenic cells using high throughput comparative proteomics approach.
The presence of serum antibody to the chlamydial heat shock protein (CHSP60) as a diagnostic test for tubal factor infertility.
The Unmysterious Roles of HSP90: Ovarian Pathology and Autoantibodies.
Tubal factor infertility is associated with antibodies against Chlamydia trachomatis heat shock protein 60 (HSP60) but not human HSP60.
[Serologic diagnosis of chlamydial and Mycoplasma pneumoniae infections]
Infertility, Female
Immune-mediated destruction of ovarian follicles associated with the presence of HSP90 antibodies.
Infertility, Male
A mutation in Thermosensitive Male Sterile 1, encoding a heat shock protein with DnaJ and PDI domains, leads to thermosensitive gametophytic male sterility in Arabidopsis.
Bat3 deficiency accelerates the degradation of Hsp70-2/HspA2 during spermatogenesis.
Decreased expression of the heat shock protein hsp70-2 is associated with the pathogenesis of male infertility.
Dephosphorylation of protamine 2 at serine 56 is crucial for murine sperm maturation in vivo.
Genetic analysis of viable Hsp90 alleles reveals a critical role in Drosophila spermatogenesis.
HSPA1L and HSPA1B gene polymorphisms and haplotypes are associated with idiopathic male infertility in Iranian population.
Mutations in DNAJB13, Encoding an HSP40 Family Member, Cause Primary Ciliary Dyskinesia and Male Infertility.
Targeted gene disruption of Hsp70-2 results in failed meiosis, germ cell apoptosis, and male infertility.
The association of rs11457523 in HSP90AA1 with idiopathic male infertility in the Chinese population.
The role of heat shock protein 70 (Hsp 70) in male infertility: is it a line of defense against sperm DNA fragmentation?
Inflammatory Bowel Diseases
Autoantibodies to human stress proteins. A survey of various rheumatic and other inflammatory diseases.
Cellular and humoral immunity to the 60-kD heat shock protein in inflammatory bowel disease.
De novo and rare mutations in the HSPA1L heat shock gene associated with inflammatory bowel disease.
Enhanced intestinal expression of heat shock protein 70 in patients with inflammatory bowel diseases.
Evaluation of ubiquitinated proteins by proteomics reveals the role of the ubiquitin proteasome system in the regulation of Grp75 and Grp78 chaperone proteins during intestinal inflammation.
Heat shock protein 47 can be a new target molecule for intestinal fibrosis related to inflammatory bowel disease.
How autophagy controls the intestinal epithelial barrier.
Hsp60 and Hsp10 increase in colon mucosa of Crohn's disease and ulcerative colitis.
Impaired humoral immune response against mycobacterial 65-kDa heat shock protein (HSP65) in patients with inflammatory bowel disease.
Intestinal expression of human heat shock protein 90 in patients with Crohn's disease and ulcerative colitis.
Involvement of heat shock protein a4/apg-2 in refractory inflammatory bowel disease.
Mucosal expression by B7-positive cells of the 60-kilodalton heat-shock protein in inflammatory bowel disease.
Oral targeted delivery by nanoparticles enhances efficacy of an Hsp90 inhibitor by reducing systemic exposure in murine models of colitis and colitis-associated cancer.
Peripheral blood mononuclear cell proliferative responses to soluble and particulate heat shock protein 65 in health and inflammatory bowel disease.
RNF186 regulates EFNB1 (ephrin B1)-EPHB2-induced autophagy in the colonic epithelial cells for the maintenance of intestinal homeostasis.
Targeted Inhibition of Heat Shock Protein 90 Suppresses Tumor Necrosis Factor-? and Ameliorates Murine Intestinal Inflammation.
[Induction of mucosal immunity to mycobacterial heat shock protein (hsp) 65 by colonic inoculation of plasmid DNA encoding hsp65]
Influenza in Birds
Identification of Hsp90 as a species independent H5N1 avian influenza A virus PB2 interacting protein.
[Complex of recombinant heat shock protein with lipopolysaccharide induces rapid protection of mice against Salmonella typhimurium and avirulent for humans avian influenza virus H5N2]
Influenza, Human
A truncated C-terminal fragment of Mycobacterium tuberculosis HSP70 enhances cell-mediated immune response and longevity of the total IgG to influenza A virus M2e protein in mice.
Anti-influenza virus activity of benzo[d]thiazoles that target heat shock protein 90.
AR-12 Inhibits Multiple Chaperones Concomitant With Stimulating Autophagosome Formation Collectively Preventing Virus Replication.
Autophagy is involved in regulating influenza A virus RNA and protein synthesis associated with both modulation of Hsp90 induction and mTOR/p70S6K signaling pathway.
Broadly Protective CD8+ T Cell Immunity to Highly Conserved Epitopes Elicited by Heat Shock Protein gp96-Adjuvanted Influenza Monovalent Split Vaccine.
Construction of recombinant fusion protein of influenza, a virus neuraminidase and heat shock protein 70 gene: expression in baculovirus and bioactivity.
Epitope tagging of the human endoplasmic reticulum HSP70 protein, BiP, to facilitate analysis of BiP--substrate interactions.
Functional role of Hsp60 as a positive regulator of human viral infection progression.
Harnessing an RNA-mediated chaperone for the assembly of influenza hemagglutinin in an immunologically relevant conformation.
Heat shock protein 70 inhibits the activity of influenza a virus ribonucleoprotein and blocks the replication of virus in vitro and in vivo.
Heat shock protein 70 is related to thermal inhibition of nuclear export of the influenza virus ribonucleoprotein complex.
Heat shock protein 70 modulates influenza a virus polymerase activity.
Heat shock protein gp96 adjuvant induces T cell responses and cross-protection to a split influenza vaccine.
Hsc70 regulates the nuclear export but not the import of influenza viral RNP: A possible target for the development of anti-influenza virus drugs.
Hsp90 inhibitors reduce influenza virus replication in cell culture.
Human Heat shock protein 40 (Hsp40/DnaJB1) promotes influenza A virus replication by assisting nuclear import of viral ribonucleoproteins.
Identification of Hsc70 as an influenza virus matrix protein (M1) binding factor involved in the virus life cycle.
Identification of Hsp90 as a stimulatory host factor involved in influenza virus RNA synthesis.
Identification of immunoglobulin heavy chain binding protein as glucose-regulated protein 78 on the basis of amino acid sequence, immunological cross-reactivity, and functional activity.
Influenza A Viral Replication Is Blocked by Inhibition of the Inositol-requiring Enzyme 1 (IRE1) Stress Pathway.
Influenza A Virus Induces Autophagy by Its Hemagglutinin Binding to Cell Surface Heat Shock Protein 90AA1.
Influenza A virus neuraminidase protein interacts with Hsp90, to stabilize itself and enhance cell survival.
Influenza A virus nucleoprotein exploits Hsp40 to inhibit PKR activation.
Influenza virus budding does not require a functional AAA+ ATPase, VPS4.
Influenza Virus Infection Induces the Nuclear Relocalization of the Hsp90 Co-Chaperone p23 and Inhibits the Glucocorticoid Receptor Response.
Influenza virus inhibits cleavage of the HSP70 pre-mRNAs at the polyadenylation site.
Interaction of Hsp40 with influenza virus M2 protein: implications for PKR signaling pathway.
Involvement of Hsp90 in assembly and nuclear import of influenza virus RNA polymerase subunits.
MC1568 inhibits HDAC6/8 activity and influenza A virus replication in lung epithelial cells: role of Hsp90 acetylation.
Nuclear export of the influenza virus ribonucleoprotein complex: Interaction of Hsc70 with viral proteins M1 and NS2.
PBP74, a new member of the mammalian 70-kDa heat shock protein family, is a mitochondrial protein.
Protection against influenza H7N9 virus challenge with a recombinant NP-M1-HSP60 protein vaccine construct in BALB/c mice.
Responses to gram negative enteric bacterial antigens by synovial T cells from patients with juvenile chronic arthritis: recognition of heat shock protein HSP60.
Selective response of gamma delta T-cell hybridomas to orthomyxovirus-infected cells.
Subcellular localization and interactions of Infectious Salmon Anemia Virus (ISAV) M1 and NEP as well as host Hsc70.
Synthetic peptides non-covalently bound to bacterial hsp 70 elicit peptide-specific T-cell responses in vivo.
Synthetic peptides representing T-cell epitopes act as carriers in pneumococcal polysaccharide conjugate vaccines.
The cellular inhibitor of the PKR protein kinase, P58(IPK), is an influenza virus-activated co-chaperone that modulates heat shock protein 70 activity.
The effect of C-terminal mutations of HSP60 on protein folding.
The impact of DR3 microvariation on peptide binding: the combinations of specific DR beta residues critical to binding differ for different peptides.
The NS1 protein of influenza a virus interacts with heat shock protein Hsp90 in human alveolar basal epithelial cells: implication for virus-induced apoptosis.
Insulin Resistance
Activating HSP72 in rodent skeletal muscle increases mitochondrial number and oxidative capacity and decreases insulin resistance.
Adipocytes from new zealand obese mice exhibit aberrant proinflammatory reactivity to the stress signal heat shock protein 60.
Aging Does Not Reduce Heat Shock Protein 70 in the Absence of Chronic Insulin Resistance.
AMP-activated protein kinase-mediated expression of heat shock protein beta 1 enhanced insulin sensitivity in the skeletal muscle.
An acylic polyisoprenoid derivative, geranylgeranylacetone protects against visceral adiposity and insulin resistance in high-fat-fed mice.
Anti-diabetic effect and mechanism of Kursi Wufarikun Ziyabit in L6 rat skeletal muscle cells.
Association of extracellular heat shock protein 70 and insulin resistance in type 2 diabetes; independent of obesity and C-reactive protein.
Attenuation of exercise-induced heat shock protein 72 expression blunts improvements in whole-body insulin resistance in rats with type 2 diabetes.
Calreticulin and Hsp90 stabilize the human insulin receptor and promote its mobility in the endoplasmic reticulum.
Central ceramide-induced hypothalamic lipotoxicity and ER stress regulate energy balance.
Chaperone-Based Therapeutic Target Innovation: Heat Shock Protein 70 (HSP70) for Type 2 Diabetes Mellitus.
Decreased expression of heat shock protein 20 in colorectal cancer and its implication in tumorigenesis.
Decreased expression of heat shock protein 72 in skeletal muscle of patients with type 2 diabetes correlates with insulin resistance.
Disruption of cyclophilin D-mediated calcium transfer from the ER to mitochondria contributes to hepatic ER stress and insulin resistance.
Effects of insulin resistance on geranylgeranylacetone-induced expression of heat shock protein 72 and cardioprotection in high-fat diet rats.
Endoplasmic reticulum chaperone GRP78 regulates macrophage function and insulin resistance in diet-induced obesity.
Glucose oxidase induces insulin resistance via influencing multiple targets in vitro and in vivo: The central role of oxidative stress.
Grp78 Heterozygosity Promotes Adaptive Unfolded Protein Response and Attenuates Diet-Induced Obesity and Insulin Resistance.
GRP78 overproduction in pancreatic beta cells protects against high-fat-diet-induced diabetes in mice.
Heat Shock Protein 60 as a Mediator of Adipose Tissue Inflammation and Insulin Resistance.
Heat shock protein 90 (HSP90) inhibitors activate the heat shock factor 1 (HSF1) stress response pathway and improve glucose regulation in diabetic mice.
Heat shock proteins in obesity: links to cardiovascular disease.
Heat shock response regulates insulin sensitivity and glucose homeostasis: pathophysiological impact and therapeutic potential.
Heat shock treatment with mild electrical stimulation safely reduced inflammatory markers in healthy male subjects.
Heat treatment improves glucose tolerance and prevents skeletal muscle insulin resistance in rats fed a high-fat diet.
HSP60 reduction protects against diet-induced obesity by modulating energy metabolism in adipose tissue.
Hsp70 plays an important role in high-fat diet induced gestational hyperglycemia in mice.
HSP70-hom gene polymorphisms modify the association of diethylhexyl phthalates with insulin resistance.
HSP72 protects against obesity-induced insulin resistance.
Hsp90? knockdown in DIO mice reverses insulin resistance and improves glucose tolerance.
Human skeletal muscle mitochondrial dynamics in relation to oxidative capacity and insulin sensitivity.
Hypertrophic Adipocyte-Derived Exosomal miR-802-5p Contributes to Insulin Resistance in Cardiac Myocytes Through Targeting HSP60.
Impaired Oxidative Metabolism and Inflammation are Associated with Insulin Resistance in ER{alpha} Deficient Mice.
Improvement of insulin sensitivity by a novel drug candidate, BGP-15, in different animal studies.
Inducing Muscle Heat Shock Protein 70 Improves Insulin Sensitivity and Muscular Performance in Aged Mice.
Induction chemotherapy reduces extracellular heat shock protein 72 levels, inflammation, lipoperoxidation and changes insulin sensitivity in children and adolescents newly diagnosed with acute lymphoblastic leukemia.
Induction of heat shock proteins may combat insulin resistance.
Inhibition of matrix metalloproteinase-2 improves endothelial function and prevents hypertension in insulin resistant rats.
Insulin resistance contributes to multidrug resistance in HepG2 cells via activation of the PERK signaling pathway and upregulation of Bcl-2 and P-gp.
Intramuscular heat shock protein 72 and heme oxygenase-1 mRNA are reduced in patients with type 2 diabetes: evidence that insulin resistance is associated with a disturbed antioxidant defense mechanism.
Involvement of endoplasmic reticulum stress in insulin resistance and diabetes.
Jiangtang Xiaoke granule attenuates glucose metabolism disorder via regulating endoplasmic reticulum stress in the liver of type 2 diabetes mellitus mice.
Leptin regulation of Hsp60 impacts hypothalamic insulin signaling.
Methylglyoxal attenuates insulin signaling and downregulates the enzymes involved in cholesterol biosynthesis.
Mild Electrical Stimulation with Heat Shock Reduces Visceral Adiposity and Improves Metabolic Abnormalities in Subjects with Metabolic Syndrome or Type 2 Diabetes: Randomized Crossover Trials.
Mitochondrial stress protein HSP60 regulates ER stress-induced hepatic lipogenesis.
Muscle Heat Shock Protein 70 Predicts Insulin Resistance With Aging.
Oral supplementations with L-glutamine or L-alanyl-L-glutamine do not change metabolic alterations induced by long-term high-fat diet in the B6.129F2/J mouse model of insulin resistance.
Pancreastatin inhibitor activates AMPK pathway via GRP78 and ameliorates dexamethasone induced fatty liver disease in C57BL/6 mice.
Passive exposure to heat improves glucose metabolism in overweight humans.
Plasma HSP70 Levels Correlate with Health Risk Factors and Insulin Resistance in African American Subjects.
Reduced nuclear protein 1 expression improves insulin sensitivity and protects against diet-induced glucose intolerance through up-regulation of heat shock protein 70.
Reduction of endoplasmic reticulum stress using chemical chaperones or Grp78 overexpression does not protect muscle cells from palmitate-induced insulin resistance.
Serum heat shock protein 27 antigen and antibody levels appear to be related to the macrovascular complications associated with insulin resistance: a pilot study.
Skeletal muscle-specific overexpression of heat shock protein 72 improves skeletal muscle insulin-stimulated glucose uptake but does not alter whole body metabolism.
Strength training improves insulin resistance and differently affects mitochondria in skeletal muscle and visceral adipose tissue in high-fat fed mice.
The endoplasmic reticulum chaperone improves insulin resistance in type 2 diabetes.
The relationship between heat shock protein 72 expression in skeletal muscle and insulin sensitivity is dependent on adiposity.
TIMING OF ACUTE PASSIVE HEATING ON GLUCOSE TOLERANCE AND BLOOD PRESSURE IN PEOPLE WITH TYPE 2 DIABETES: A RANDOMIZED, BALANCED CROSSOVER, CONTROL TRIAL.
Tissue-specific regulation and expression of heat shock proteins in type 2 diabetic monkeys.
Transthyretin contributes to insulin resistance and diminishes exercise-induced insulin sensitivity in obese mice by inhibiting AMPK activity in skeletal muscle.
[Effect and Mechanism of Litchi Semen Effective Constituents on Insulin Resistance in Rats with Type 2 Diabetes Mellitus].
[The role of hsp60 and hsp70 kDa heat shock protein families in different types of diabetes mellitus]
Insulinoma
Attenuation of unfolded protein response and apoptosis by mReg2 induced GRP78 in mouse insulinoma cells.
Endoplasmic reticulum redox state is not perturbed by pharmacological or pathological endoplasmic reticulum stress in live pancreatic ?-cells.
Glucose regulated proteins 78 protects insulinoma cells (NIT-1) from death induced by streptozotocin, cytokines or cytotoxic T lymphocytes.
Identification and characterization of interactions between abscisic acid and human heat shock protein 70 family members.
Methoxyflavones protect cells against endoplasmic reticulum stress and neurotoxin.
NOD mouse diabetes: the ubiquitous mouse hsp60 is a beta-cell target antigen of autoimmune T cells.
Proteome of the insulin-secreting Min6 cell porosome complex: involvement of Hsp90 in its assembly and function.
The immunosuppressive and protective ability of glucose-regulated protein 78 for improvement of alloimmunity in beta cell transplantation.
Intellectual Disability
Truncating biallelic variant in DNAJA1, encoding the co-chaperone Hsp40, is associated with intellectual disability and seizures.
Intervertebral Disc Degeneration
A comparative study of localization of heat shock protein 27 and heat shock protein 72 in the developmental and degenerative intervertebral discs.
Expression of HSPA8 in Nucleus Pulposus of Lumbar Intervertebral Disc and Its Effect on Degree of Degeneration.
Intestinal Failure
Radicicol, an Hsp90 inhibitor, inhibits intestinal inflammation and leakage in abdominal sepsis.
Intestinal Fistula
Polymorphism of heat shock protein 70-2 and enterocutaneous fistula in Chinese population.
Intestinal Neoplasms
Heterozygosity of chaperone Grp78 reduces intestinal stem cell regeneration potential and protects against adenoma formation.
Intestinal Volvulus
Characterization of an hsp70 gene from the human filarial parasite, Brugia malayi (Nematoda).
Onchocerca volvulus heat shock protein 70 is a major immunogen in amicrofilaremic individuals from a filariasis-endemic area.
The mitochondrial heat shock protein 60 (HSP60) is up-regulated in Onchocerca volvulus after the depletion of Wolbachia.
Intracranial Hemorrhages
Neuron-Specific Enolase, S100 Calcium-Binding Protein B, and Heat Shock Protein 70 Levels in Patients With Intracranial Hemorrhage.
The 70 kDa heat shock protein protects against experimental traumatic brain injury.
Invasive Fungal Infections
COVID19 associated mucormycosis: Is GRP78 a possible link?
Design and synthesis of fungal-selective resorcylate aminopyrazole Hsp90 inhibitors.
Iridocyclitis
Heat shock protein peptides reactive in patients with Behçet's disease are uveitogenic in Lewis rats.
Iron Deficiencies
Enhanced hydrogen peroxide sensitivity and altered stress protein expression in iron-starved Mycobacterium smegmatis.
Irritable Bowel Syndrome
Heat Shock Protein 27 Regulates the Inflammatory Response of Intestinal Epithelial Cells by the Nuclear Factor-?B Pathway.
Heat shock protein 70 protects mouse against post-infection irritable bowel syndrome via up-regulating intestinal ?? T cell's Th17 response.
Preinduced intestinal HSP70 improves visceral hypersensitivity and abnormal intestinal motility in PI-IBS mouse model.
Preinduction of heat shock protein 70 protects mice against post-infection irritable bowel syndrome via NF-?B and NOS/NO signaling pathways.
Ischemic Attack, Transient
Disturbances of calcium homeostasis within the endoplasmic reticulum may contribute to the development of ischemic-cell damage.
Effects of transient cerebral ischemia on hsp40 mRNA levels in rat brain.
Immunoelectron microscopic study of c-Fos, c-Jun and heat shock protein after transient cerebral ischemia in gerbils.
[Dynamic cellular response following brain ischemia and reperfusion]
Ischemic Stroke
Correlation of lymphocyte heat shock protein 70 levels with neurologic deficits in elderly patients with cerebral infarction.
Downregulation of miR-181b in mouse brain following ischemic stroke induces neuroprotection against ischemic injury through targeting heat shock protein A5 and ubiquitin carboxyl-terminal hydrolase isozyme L1.
Downregulation of miRNA-134 protects neural cells against ischemic injury in N2A cells and mouse brain with ischemic stroke by targeting HSPA12B.
EF1A1/HSC70 Cooperatively Suppress Brain Endothelial Cell Apoptosis via Regulating JNK Activity.
Effects of polymorphisms of heat shock protein 70 gene on ischemic stroke, and interaction with smoking in China.
Exploring molecular mechanism underlying Chinese medicine syndrome: A study on correlation between Chinese medicine syndrome and biomarkers for ischemic stroke.
GRP78 Promotes Neural Stem Cell Antiapoptosis and Survival in Response to Oxygen-Glucose Deprivation (OGD)/Reoxygenation through PI3K/Akt, ERK1/2, and NF-?B/p65 Pathways.
Heat shock protein 27 as a neuroprotective biomarker and a suitable target for stem cell therapy and pharmacotherapy in ischemic stroke.
Heat shock protein 90 inhibition by 17-Dimethylaminoethylamino-17-demethoxygeldanamycin protects blood-brain barrier integrity in cerebral ischemic stroke.
Heat shock protein A12A encodes a novel prosurvival pathway during ischaemic stroke.
HSPB8 overexpression prevents disruption of blood-brain barrier after intracerebral hemorrhage in rats through Akt/GSK3?/?-catenin signaling pathway.
Neurotherapeutic activity of the recombinant heat shock protein Hsp70 in a model of focal cerebral ischemia in rats.
Protecting against ischaemic stroke in rats by heat shock protein 20-mediated exercise.
Semi-quantitative analyses of hippocampal heat shock protein-70 expression based on the duration of ischemia and the volume of cerebral infarction in mice.
Serum levels of heat shock protein 27 in patients with acute ischemic stroke.
Stem Cell-Like Dog Placenta Cells Afford Neuroprotection against Ischemic Stroke Model via Heat Shock Protein Upregulation.
The Hsp90 Inhibitor 17-DMAG Attenuates Hyperglycemia-Enhanced Hemorrhagic Transformation in Experimental Stroke.
Toll-like receptors 2 and 4 in ischemic stroke: outcome and therapeutic values.
Up-regulation of miR-122 protects against neuronal cell death in ischemic stroke through the heat shock protein 70-dependent NF-?B pathway by targeting FOXO3.
[Study of genetic polymorphism of heat shock protein 70-1 associated with susceptibility to ischemic stroke]
Joint Diseases
Analysis of 70Kd heat shock protein expression in patients with internal derangement of the temporomandibular joint.
Kashin-Beck Disease
Decreased Expression of Heat Shock Protein 47 Is Associated with T-2 Toxin and Low Selenium-Induced Matrix Degradation in Cartilages of Kashin-Beck Disease.
Keloid
Cell permeant peptide analogues of the small heat shock protein, HSP20, reduce TGF-beta1-induced CTGF expression in keloid fibroblasts.
Effect of heat shock protein 47 on collagen accumulation in keloid fibroblast cells.
Effect of heat shock protein 47 on collagen synthesis of keloid in vivo.
Gene Expression of Neurotrophins and Their Receptors in Keloids.
Heat Shock Protein 90 Inhibitor (17-AAG) Induces Apoptosis and Decreases Cell Migration/Motility of Keloid Fibroblasts.
Heat Shock Protein 90 Inhibitor Decreases Collagen Synthesis of Keloid Fibroblasts and Attenuates the Extracellular Matrix on the Keloid Spheroid Model.
Heat shock proteins modulate keloid formation.
Hsp70 Knockdown by siRNA Decreased Collagen Production in Keloid Fibroblasts.
HSP90 and TLR4 Interplay in Keloids.
Modulation of heat shock protein 90 affects TGF-?-induced collagen synthesis in human dermal fibroblast cells.
Mortalin deficiency suppresses fibrosis and induces apoptosis in keloid spheroids.
Nintedanib inhibits keloid fibroblast functions by blocking the phosphorylation of multiple kinases and enhancing receptor internalization.
Reply: Heat Shock Protein 90 Inhibitor (17-AAG) Induces Apoptosis and Decreases Cell Migration Motility of Keloid Fibroblasts.
Resveratrol inhibits fibrogenesis and induces apoptosis in keloid fibroblasts.
Stress chaperone mortalin regulates human melanogenesis.
Upregulation of HSP47 and collagen type III in the dermal fibrotic disease, keloid.
[Detection of expression of heat shock protein 47 mRNA in pathological scar tissue by using real-time fluorescent quantitative RT-PCR]
Keratoacanthoma
CD1A-positive cells and HSP60 (HSPD1) levels in keratoacanthoma and squamous cell carcinoma.
Keratoconjunctivitis
Heat shock protein expression in human conjunctiva.
Keratoconus
Expression of wound healing and stress-related proteins in keratoconus corneas.
Kidney Calculi
Characterizations of HSP90-Interacting Complex in Renal Cells Using Tandem Affinity Purification and Its Potential Role in Kidney Stone Formation.
Kidney Cortex Necrosis
Heat shock protein 60 is released in immune-mediated glomerulonephritis and aggravates disease: in vivo evidence for an immunologic danger signal.
Kidney Diseases
Bi-allelic pathogenic variations in DNAJB11 cause Ivemark II syndrome, a renal-hepatic-pancreatic dysplasia.
Endoplasmic reticulum stress in UMOD-related kidney disease: a human pathologic study.
Heat shock protein 60 is released in immune-mediated glomerulonephritis and aggravates disease: in vivo evidence for an immunologic danger signal.
The role of heat shock proteins in kidney disease.
Urinary Biomarkers Indicative of Apoptosis and Acute Kidney Injury in the Critically Ill.
Kidney Diseases, Cystic
A potential strategy for reducing cysts in autosomal dominant polycystic kidney disease with a CFTR corrector.
Bi-allelic pathogenic variations in DNAJB11 cause Ivemark II syndrome, a renal-hepatic-pancreatic dysplasia.
Kidney Failure, Chronic
Heat shock protein (HSP) expression and proliferation of tubular cells in end stage renal disease with and without haemodialysis.
Kidney Neoplasms
17-Allylamino-17-demethoxygeldanamycin and ritonavir inhibit renal cancer growth by inhibiting the expression of heat shock factor-1.
Cellular stress induces cancer stem-like cells through expression of DNAJB8 by activation of heat shock factor 1.
Discovery of small molecules targeting GRP78 for antiangiogenic and anticancer therapy.
Downregulation of Cap43 gene by von Hippel-Lindau tumor suppressor protein in human renal cancer cells.
Expression of heat shock protein 72 in renal cell carcinoma: possible role and prognostic implications in cancer patients.
HSP60 silencing promotes Warburg-like phenotypes and switches the mitochondrial function from ATP production to biosynthesis in ccRCC cells.
Molecular imaging of the efficacy of heat shock protein 90 inhibitors in living subjects.
Kyphosis
Positron emission tomography in juvenile Alexander disease.
Labyrinth Diseases
A systematic review and meta-analysis of the diagnostic accuracy of anti-heat shock protein 70 antibodies for the detection of autoimmune hearing loss.
Comparison of anti-heat shock protein 70 (anti-hsp70) and anti-68-kDa inner ear protein in the sera of patients with Meniere's disease.
Expression of heat shock protein 70 in the cochlea in experimental autoimmune inner ear disease.
Recognition of a dominant epitope in bovine heat-shock protein 70 in inner ear disease.
Validity of the Western blot immunoassay for heat shock protein-70 in associated and isolated immunorelated inner ear disease.
[The role of heat shock protein 70 and its autoantibody in experimental autoimmune inner ear disease]
Lambert-Eaton Myasthenic Syndrome
GRP78 antibodies damage the blood-brain barrier and relate to cerebellar degeneration in Lambert-Eaton myasthenic syndrome.
Laryngeal Neoplasms
Effect of pepsin on laryngeal stress protein (Sep70, Sep53, and Hsp70) response: role in laryngopharyngeal reflux disease.
Overexpression of human 27 kDa heat shock protein in laryngeal cancer cells confers chemoresistance associated with cell growth delay.
Role of Krüppel-like factor 4 and heat shock protein 27 in cancer of the larynx.
[Comparative study of expression levels of the major human heat shock proteins in cancer and normal tissues]
[Expression of heat shock proteins in laryngeal carcinoma]
Laryngopharyngeal Reflux
Effect of pepsin on laryngeal stress protein (Sep70, Sep53, and Hsp70) response: role in laryngopharyngeal reflux disease.
Effects of pepsin A on heat shock protein 70 response in laryngopharyngeal reflux patients with chronic rhinosinusitis.
Expression of CAIII and Hsp70 Is Increased the Mucous Membrane of the Posterior Commissure in Laryngopharyngeal Reflux Disease.
Latent Tuberculosis
Generation of a T cell receptor (TCR)-like single domain antibody (sDAb) against a Mycobacterium Tuberculosis (Mtb) heat shock protein (HSP) 16kDa antigen presented by Human Leukocyte Antigen (HLA)-A*02.
Insights into Macrophage Autophagy in Latent Tuberculosis Infection: Role of Heat Shock Protein 16.3.
Optimisation of human VH domain antibodies specific to Mycobacterium tuberculosis heat shock protein (HSP16.3).
Legionellosis
Human and guinea pig immune responses to Legionella pneumophila protein antigens OmpS and Hsp60.
Legionnaires' Disease
Surface-associated heat shock proteins of Legionella pneumophila and Helicobacter pylori: roles in pathogenesis and immunity.
Leigh Disease
SURF1 related Leigh syndrome: Clinical and molecular findings of 16 patients from Turkey.
Leiomyoma
Expression of HSP90 in gastrointestinal stromal tumours and mesenchymal tumours.
Genistein suppresses spontaneous oviduct tumorigenesis in quail.
The effects of selenium supplementation on the spontaneously occurring fibroid tumors of oviduct, 8-hydroxy-2'-deoxyguanosine levels, and heat shock protein 70 response in Japanese quail.
Zinc picolinate in the prevention of leiomyoma in Japanese quail.
Leiomyosarcoma
Expression of HSP90 in gastrointestinal stromal tumours and mesenchymal tumours.
Leishmaniasis
Analysis of the antigenic properties of the L. infantum Hsp70: design of synthetic peptides for specific serodiagnosis of human leishmaniasis.
Antigen-reactive gamma delta T cells in human leishmaniasis.
Epitope mapping of the HSP83.1 protein of Leishmania braziliensis discloses novel targets for immunodiagnosis of tegumentary and visceral clinical forms of leishmaniasis.
Functional alterations in macrophages after hypoxia selection.
Heat shock protein 90 from neglected protozoan parasites.
Hypoxia modulates expression of the 70-kD heat shock protein and reduces Leishmania infection in macrophages.
Leishmania infantum heat shock protein 83 for the serodiagnosis of tegumentary leishmaniasis.
Leishmania major: molecular cloning, sequencing, and expression of the heat shock protein 60 gene reveals unique carboxy terminal peptide sequences.
Quantitative Proteomics Reveals that Hsp90 Inhibition Dynamically Regulates Global Protein Synthesis in Leishmania mexicana.
Leishmaniasis, Cutaneous
17-AAG-Induced Activation of the Autophagic Pathway in Leishmania Is Associated with Parasite Death.
Development and validation of PCR-based assays for diagnosis of American cutaneous leishmaniasis and identificatio nof the parasite species.
Leishmania major heat shock protein 70 (HSP70) is not protective in murine models of cutaneous leishmaniasis and stimulates strong humoral responses in cutaneous and visceral leishmaniasis patients.
Leishmaniasis, Diffuse Cutaneous
Association of Leishmania heat shock protein 83 antigen and immunoglobulin G4 antibody titers in Brazilian patients with diffuse cutaneous leishmaniasis.
Leishmaniasis, Mucocutaneous
Leishmania infantum heat shock protein 83 for the serodiagnosis of tegumentary leishmaniasis.
Leishmaniasis, Visceral
Antibodies to Leishmania donovani infantum heat-shock protein 70 in human visceral leishmaniasis.
Association analysis of HLA-class II and class III gene polymorphisms in the susceptibility to mediterranean visceral leishmaniasis.
Epitope mapping of the HSP83.1 protein of Leishmania braziliensis discloses novel targets for immunodiagnosis of tegumentary and visceral clinical forms of leishmaniasis.
Leishmania major heat shock protein 70 (HSP70) is not protective in murine models of cutaneous leishmaniasis and stimulates strong humoral responses in cutaneous and visceral leishmaniasis patients.
Recombinant Leishmania Hsp90 and Hsp70 are recognized by sera from visceral leishmaniasis patients but not Chagas' disease patients.
Recombinant Leishmania infantum Heat Shock Protein 83 for the Serodiagnosis of Cutaneous, Mucosal, and Visceral Leishmaniasis.
RFLPs of ITS, ITS1 and hsp70 amplicons and sequencing of ITS1 of recent clinical isolates of Kala-azar from India and Bangladesh confirms the association of L. tropica with the disease.
Ribosome Profiling Reveals HSP90 Inhibitor Effects on Stage-Specific Protein Synthesis in Leishmania donovani.
Lentivirus Infections
[The effect of astragalus injection on the expression of endoplasmic reticulum stress chaperonin GRP78 and GRP94 mRNA in adriamycin-injured cardiomyocytes with calumenin silencing by shRNA].
[The relationship between miRNA378, calumenin and endoplasmic reticulum stress in suckling mouse myocardium with myocarditis caused by adriamycin].
Leprosy
Anti-peripheral nerve antibodies in leprosy patients recognize an epitope shared by the M. leprae 65 kDa heat shock protein.
Characterization of circulating immune complexes in leprosy patients and their correlation with specific antibodies against Mycobacterium leprae.
Cross-reactivity of anti-10kD heat shock protein antibodies in leprosy and tuberculosis patients.
Effects of anti-endothelial cell antibodies in leprosy and malaria.
Fibronectin-binding antigen 85 and the 10-kilodalton GroES-related heat shock protein are the predominant TH-1 response inducers in leprosy contacts.
Functional characterization of a small heat shock protein from Mycobacterium leprae.
Identification of a Mycobacterium leprae-specific T cell epitope on the 70 kDa heat shock protein.
IgM anti-phenolic glycolipid I and IgG anti-10-kDa heat shock protein antibodies in sera and immune complexes isolated from leprosy patients with or without erythema nodosum leprosum and contacts.
Lysis of autologous macrophages pulsed with hsp10 from Mycobacterium leprae is associated to the absence of bacilli in leprosy.
Nerve and skin damage in leprosy is associated with increased intralesional heat shock protein.
Polymorphism in heat-shock protein 70-1 (HSP70-1) gene promoter region and susceptibility to tuberculoid leprosy and pulmonary tuberculosis in Asian Indians.
Sequence and expression of the Mycobacterium leprae dnaJ gene.
Leprosy, Lepromatous
Mycobacteria contain two groEL genes: the second Mycobacterium leprae groEL gene is arranged in an operon with groES.
Leprosy, Multibacillary
Interferon-gamma (IFN-gamma) and tumour necrosis factor-alpha (TNF-alpha) are necessary in the early stages of induction of CD4 and CD8 cytotoxic T cells by Mycobacterium leprae heat shock protein (hsp) 65 kD.
Lack of cytotoxic activity against Mycobacterium leprae 65-kD heat shock protein (hsp) in multibacillary leprosy patients.
Leprosy, Tuberculoid
Conserved TcR beta chain usage for a single MHC class II-restricted heat shock protein peptide.
Leptospirosis
AAA+ Molecular Chaperone ClpB in Leptospira interrogans: Its Role and Significance in Leptospiral Virulence and Pathogenesis of Leptospirosis.
Cloning, expression, and homology modeling of GroEL protein from Leptospira interrogans serovar autumnalis strain N2.
GroEL protein of the Leptospira spp. interacts with host proteins and induces cytokines secretion on macrophages.
Surface-associated Hsp60 chaperonin of Leptospira interrogans serovar Autumnalis N2 strain as an immunoreactive protein.
Leukemia
28-kDa mammalian heat shock protein, a novel substrate of a growth regulatory protease involved in differentiation of human leukemia cells.
5-Episinuleptolide Acetate, a Norcembranoidal Diterpene from the Formosan Soft Coral Sinularia sp., Induces Leukemia Cell Apoptosis through Hsp90 Inhibition.
A Mitochondrial-targeted purine-based HSP90 antagonist for leukemia therapy.
A novel dual HDAC and HSP90 inhibitor, MPT0G449, downregulates oncogenic pathways in human acute leukemia in vitro and in vivo.
Aberrant protein expression in cerebral cortex of fetus with Down syndrome.
Analysis of cell surface and relative gene expression of heat shock protein 70 in human leukemia cell lines.
Andrographolide downregulates the v-Src and Bcr-Abl oncoproteins and induces Hsp90 cleavage in the ROS-dependent suppression of cancer malignancy.
Anti-proliferative activity of heat shock protein (Hsp) 90 inhibitors via beta-catenin/TCF7L2 pathway in adult T cell leukemia cells.
Attenuation of the induced differentiation of HL-60 leukemia cells by mitochondrial chaperone HSP70.
BIIB021, an Hsp90 inhibitor: A promising therapeutic strategy for blood malignancies (Review).
Caspase-dependent, geldanamycin-enhanced cleavage of co-chaperone p23 in leukemic apoptosis.
Clinical correlation of circulating heat shock protein 70 in acute leukemia.
Clonogenicity of human leukemic cells protected from cell-lethal agents by heat shock protein 70.
Coadministration of the heat shock protein 90 antagonist 17-allylamino- 17-demethoxygeldanamycin with suberoylanilide hydroxamic acid or sodium butyrate synergistically induces apoptosis in human leukemia cells.
Combination of the histone deacetylase inhibitor LBH589 and the hsp90 inhibitor 17-AAG is highly active against human CML-BC cells and AML cells with activating mutation of FLT-3.
Combined use of dendritic cells enhances specific antileukemia immunity by leukemia cell-derived heat shock protein 70 in a mouse model with minimal residual leukemia cells.
Correlation between HSP90 induction kinetics in murine leukemia cells and the amount of cisplatin over a wide range of cytostatic concentrations.
Cotreatment with 17-allylamino-demethoxygeldanamycin and FLT-3 kinase inhibitor PKC412 is highly effective against human acute myelogenous leukemia cells with mutant FLT-3.
Cotreatment with suberanoylanilide hydroxamic acid and 17-allylamino 17-demethoxygeldanamycin synergistically induces apoptosis in Bcr-Abl+ Cells sensitive and resistant to STI571 (imatinib mesylate) in association with down-regulation of Bcr-Abl, abrogation of signal transducer and activator of transcription 5 activity, and Bax conformational change.
Curcumin derivative C212 inhibits Hsp90 and eliminates both growing and quiescent leukemia cells in deep dormancy.
Current Understanding of HSP90 as a Novel Therapeutic Target: An Emerging Approach for the Treatment of Cancer.
Dendritic cells pulsed with leukemia cell-derived exosomes more efficiently induce antileukemic immunities.
Deregulated expression of the HSP40 family members Auxilin-1 and -2 is indicative of proteostasis imbalance and predicts patient outcome in Ph(+) leukemia.
Differential expression of immune system-related components in midtrimester amniotic fluid from singleton and twin pregnancies.
Dinaciclib (SCH727965) Inhibits the Unfolded Protein Response through a CDK1- and 5-Dependent Mechanism.
Disruption of the Bcr-Abl/Hsp90 protein complex: a possible mechanism to inhibit Bcr-Abl-positive human leukemic blasts by novobiocin.
Down-regulation of a Mr 90,000 heat shock cognate protein during granulocytic differentiation in HL-60 human leukemia cells.
Effect of ELF-EMF on number of apoptotic cells; correlation with reactive oxygen species and HSP.
Effect of recombinant heat shock protein 70 of mycobacterial origin on cytotoxic activity and immunophenotype of human peripheral blood mononuclear leukocytes.
Effectiveness of HSV-tk suicide gene therapy driven by the Grp78 stress-inducible promoter in esophagogastric junction and gastric adenocarcinomas.
Effects of endoplasmic reticulum stress on autophagy and apoptosis of human leukemia cells via inhibition of the PI3K/AKT/mTOR signaling pathway.
Effects of extremely low frequency magnetic fields on NGF induced neuronal differentiation of PC12 cells.
Eradication of murine mammary adenocarcinoma through HSVtk expression directed by the glucose-starvation inducible grp78 promoter.
Evolutionary significance of intra-genome duplications on human chromosomes.
Expression of ERp5 and GRP78 on the membrane of chronic lymphocytic leukemia cells: association with soluble MICA shedding.
F1F0-ATP synthase functions as a co-chaperone of Hsp90-substrate protein complexes.
FLT3 expressing leukemias are selectively sensitive to inhibitors of the molecular chaperone heat shock protein 90 through destabilization of signal transduction-associated kinases.
Geldanamycin and its anti-cancer activities.
GRP78-targeted in-silico virtual screening of novel anticancer agents.
HDAC6 inhibition enhances 17-AAG--mediated abrogation of hsp90 chaperone function in human leukemia cells.
HDN-1 induces cell differentiation toward apoptosis in promyelocytic leukemia cells depending on its selective effect on client proteins of Hsp90.
Heat shock protein 70 regulates Tcl1 expression in leukemia and lymphomas.
Heat shock protein 90 and role of its chemical inhibitors in treatment of hematologic malignancies.
Heat shock protein 90 inhibition depletes TrkA levels and signaling in human acute leukemia cells.
Heat shock protein 90 interacts with vitamin D receptor in human leukemia cells.
Heat shock protein 90 regulates the expression of Wilms' tumor 1 protein in myeloid leukemias.
Heat shock protein 90.
Heat shock protein 90: a potential therapeutic target in leukemic progenitor and stem cells harboring mutant BCR-ABL resistant to kinase inhibitors.
Heat-shock protein expression in leukemia.
High constitutive expression of heat shock protein 90 alpha in human acute leukemia cells.
High expression of heat shock protein 90 alpha and its significance in human acute leukemia cells.
Homoharringtonine Combined with the Heat Shock Protein 90 Inhibitor IPI504 in the Treatment of FLT3-ITD Acute Myeloid Leukemia.
Hsp27 expression in neuroblastoma: correlation with disease stage.
Hsp90 cleavage by an oxidative stress leads to its client proteins degradation and cancer cell death.
HSP90 inhibitor 17AAG causes apoptosis in ATRA-resistant acute promyelocytic leukemia cells.
HSP90 inhibitor AUY922 induces cell death by disruption of the Bcr-Abl, Jak2 and HSP90 signaling network complex in leukemia cells.
HSP90 inhibitor NVP-BEP800 affects stability of SRC kinases and growth of T-cell and B-cell acute lymphoblastic leukemias.
HSP90 inhibitor, celastrol, arrests human monocytic leukemia cell U937 at G0/G1 in thiol-containing agents reversible way.
Hsp90 inhibitors and drug resistance in cancer: The potential benefits of combination therapies of Hsp90 inhibitors and other anti-cancer drugs.
Hsp90 N- and C-terminal double inhibition synergistically suppresses Bcr-Abl-positive human leukemia cells.
Hsp90-mediated inactivation of NF{kappa}B switches autophagy to apoptosis through becn1 transcriptional inhibition in selenite-induced NB4 cells.
Human leukemias with mutated FLT3 kinase are synergistically sensitive to FLT3 and Hsp90 inhibitors: the key role of the STAT5 signal transduction pathway.
Human T cell leukemia virus type 1 Tax associates with a molecular chaperone complex containing hTid-1 and Hsp70.
Identification and characterization of a 66-68-kDa protein as a methotrexate-binding protein in murine leukemia L1210 cells.
Identification of an overexpressed gene, HSPA4L, the product of which can provoke prevalent humoral immune responses in leukemia patients.
Identification of mixed lineage leukemia 1(MLL1) protein as a coactivator of heat shock factor 1(HSF1) protein in response to heat shock protein 90 (HSP90) inhibition.
Identification of novel lipid droplet factors that regulate lipophagy and cholesterol efflux in macrophage foam cells.
IKK{gamma} protein is a target of BAG3 regulatory activity in human tumor growth.
Impact of USP8 Gene Mutations on Protein Deregulation in Cushing Disease.
Inducible knockout of GRP78/BiP in the hematopoietic system suppresses Pten-null leukemogenesis and AKT oncogenic signaling.
Induction of human hsp60 expression in monocytic cell lines.
Influence of rate of heating on thermosensitivity of L1210 leukemia: membrane lipids and Mr 70,000 heat shock protein.
Inhibition of heat shock protein 90 prolongs survival of mice with BCR-ABL-T315I-induced leukemia and suppresses leukemic stem cells.
Inhibition of histone deacetylase 6 acetylates and disrupts the chaperone function of heat shock protein 90: a novel basis for antileukemia activity of histone deacetylase inhibitors.
Inhibition of the mTORC2 and chaperone pathways to treat leukemia.
Initial testing (stage 1) of ganetespib, an Hsp90 inhibitor, by the pediatric preclinical testing program.
Interleukin (IL)-6 signaling leads to phosphorylation of the small heat shock protein (Hsp)27 through activation of the MAP kinase and MAPKAP kinase 2 pathway in monocytes and monocytic leukemia cells.
Interleukin-3 and granulocyte-macrophage colony-stimulating factor induce activation of the MAPKAP kinase 2 resulting in in vitro serine phosphorylation of the small heat shock protein (Hsp 27).
Involvement of p38 in signal switching from autophagy to apoptosis via the PERK/eIF2?/ATF4 axis in selenite-treated NB4 cells.
Isolation of MHC class I-restricted tumor antigen peptide and its precursors associated with heat shock proteins hsp70, hsp90, and gp96.
Leukemia inhibitory factor promotes Hsp90 association with STAT3 in mouse embryonic stem cells.
LSK derived LSK- cells have a high apoptotic rate related to survival regulation of hematopoietic and leukemic stem cells.
Mechanistic role of heat shock protein 70 in Bcr-Abl-mediated resistance to apoptosis in human acute leukemia cells.
Modulating Heat Shock Proteins 70 and 90 Expression by Low Power Laser Irradiation (635nm and 780nm) in Jurkat E6.1 T-lymphocyte Leukemia Cell Line.
Molecular and biologic characterization and drug sensitivity of pan-histone deacetylase inhibitor-resistant acute myeloid leukemia cells.
Mortalin inhibitors sensitize K562 leukemia cells to complement-dependent cytotoxicity.
Neferine in the Lotus Plumule Potentiates the Antitumor Effect of Imatinib in Primary Chronic Myeloid Leukemia Cells In Vitro.
Neuronal intranuclear inclusion disease without polyglutamine inclusions in a child.
Phase I and pharmacological study of cytarabine and tanespimycin in relapsed and refractory acute leukemia.
Plasma Hsp90 Level as a Marker of Early Acute Lymphoblastic Leukemia Engraftment and Progression in Mice.
Possible effects of early treatments of hsp90 inhibitors on preventing the evolution of drug resistance to other anti-cancer drugs.
Power-line frequency electromagnetic fields do not induce changes in phosphorylation, localization, or expression of the 27-kilodalton heat shock protein in human keratinocytes.
Proliferation of hematopoietic cells is accompanied by suppressed expression of heat shock protein 70.
Proteasome inhibitor-induced cleavage of HSP90 is mediated by ROS generation and caspase 10-activation in human leukemic cells.
Regulation of activation-induced deaminase stability and antibody gene diversification by Hsp90.
Selective apoptosis of tandemly duplicated FLT3-transformed leukemia cells by Hsp90 inhibitors.
SMR peptide antagonizes mortalin promoted release of extracellular vesicles and affects mortalin protection from complement-dependent cytotoxicity in breast cancer cells and leukemia cells.
Solid lipid nanoparticles as a novel formulation approach for tanespimycin (17-AAG) against leishmania infections: Preparation, characterization and macrophage uptake.
Stressed apoptotic tumor cells stimulate dendritic cells and induce specific cytotoxic T cells.
Study of heat shock protein HSP90 alpha, HSP70, HSP27 mRNA expression in human acute leukemia cells.
Suberoylanilide hydroxamic acid induces ROS-mediated cleavage of HSP90 in leukemia cells.
Superior activity of the combination of histone deacetylase inhibitor LAQ824 and the FLT-3 kinase inhibitor PKC412 against human acute myelogenous leukemia cells with mutant FLT-3.
SUV39H1 is a New Client Protein of Hsp90 Degradated by Chaetocin as a Novel C-Terminal Inhibitor of Hsp90.
Synergism between etoposide and 17-AAG in leukemia cells: critical roles for Hsp90, FLT3, topoisomerase II, Chk1, and Rad51.
Synergistic Anti Leukemia Effect of a Novel Hsp90 and a Pan Cyclin Dependent Kinase Inhibitors.
Synergistic antileukemic interactions between 17-AAG and UCN-01 involve interruption of RAF/MEK- and AKT-related pathways.
Synergistic Interactions between DMAG and Mitogen-Activated Protein Kinase Kinase 1/2 Inhibitors in Bcr/abl+ Leukemia Cells Sensitive and Resistant to Imatinib Mesylate.
Targeting heat shock protein 90 with non-quinone inhibitors: A novel chemotherapeutic approach in human hepatocellular carcinoma.
Targeting Hsp90 by 17-AAG in leukemia cells: mechanisms for synergistic and antagonistic drug combinations with arsenic trioxide and Ara-C.
Targeting HSP90 dimerization via the C terminus is effective in imatinib-resistant CML and lacks the heat shock response.
The Hsp90 inhibitor geldanamycin selectively sensitizes Bcr-Abl-expressing leukemia cells to cytotoxic chemotherapy.
The Hsp90 inhibitor SNX-7081 is synergistic with fludarabine nucleoside via DNA damage and repair mechanisms in human, p53-negative chronic lymphocytic leukemia.
The preparation of leukemia cell vaccine expressing BCG heat shock protein 70 and anti-leukemia effect in vitro.
The synthetic heat shock protein 90 (Hsp90) inhibitor EC141 induces degradation of Bcr-Abl p190 protein and apoptosis of Ph-positive acute lymphoblastic leukemia cells.
The transcription factor Wilms tumor 1 confers resistance in myeloid leukemia cells against the proapoptotic therapeutic agent TRAIL by regulating the antiapoptotic protein Bcl-xL.
Therapeutic targeting of membrane-associated GRP78 in leukemia and lymphoma: preclinical efficacy in vitro and formal toxicity study of BMTP-78 in rodents and primates.
Tricyclic series of heat shock protein 90 (Hsp90) inhibitors part I: discovery of tricyclic imidazo[4,5-c]pyridines as potent inhibitors of the Hsp90 molecular chaperone.
Tumor-derived multiple chaperone enrichment by free-solution isoelectric focusing yields potent antitumor vaccines.
Tumor-specific HSP90 inhibition as a therapeutic approach in JAK-mutant acute lymphoblastic leukemias.
Tyrosine phosphorylation of HSC70 and its interaction with RFC mediates methotrexate resistance in murine L1210 leukemia cells.
Use of the glucose starvation-inducible glucose-regulated protein 78 promoter in suicide gene therapy of murine fibrosarcoma.
VEGF(165) promotes survival of leukemic cells by Hsp90-mediated induction of Bcl-2 expression and apoptosis inhibition.
Y-632 inhibits Hsp90 function through disrupting the interaction of Hsp90-Hop and exerts antitumor activity in vitro and in vivo.
ZAP-70 is a novel conditional heat shock protein 90 (Hsp90) client: inhibition of Hsp90 leads to ZAP-70 degradation, apoptosis, and impaired signaling in chronic lymphocytic leukemia.
[CD133 epitope vaccine with gp96 as adjuvant elicits an antitumor T cell response against leukemia].
[Expression and Significance of PD-L1, HSP90 and HSP90? in Serum of Patients with Acute Leukemia].
[Expression characteristics of heat shock protein 70 and pim-1 gene in bone marrow mononuclear cells from leukemia patients and their clinical significance]
[Gene Expression Profile of Apoptosis in Leukemia Cells Induced by Hsp90 Selective inhibitor 17-AAG].
[Preparation of Heat Shock Protein 70 (Hsp70) and Idiotypic Determinant Single-chain Antibody (Id-ScFv) in a Patient with B-cell Chronic Lymphatic Leukemia (B-CLL) and Antitumor Effect of Peptide Complex Hsp70-Id.]
[Proliferation and Apoptosis of Leukemia Cell Line K562 Treated with HSP90 Inhibitor 17-DMAG].
[Study on signal transduction pathway in differentiation and apoptosis of leukemia cells induced by heat shock protein inhibitor]
[Thapsigargin-induced apoptosis of K562 cells and its mechanism.]
[The Hsp90 inhibitor FW-04-806 suppresses Bcr/Abl-mediated growth of leukemia cells by inhibiting proliferation and inducing apoptosis].
[The mechanism of apoptosis of chronic myeloid leukemia cells induced by the novel p210 bcr/abl inhibitor berbamine]
Leukemia L1210
Tyrosine phosphorylation of HSC70 and its interaction with RFC mediates methotrexate resistance in murine L1210 leukemia cells.
Leukemia, B-Cell
AIDing cancer treatment: Reducing AID activity via HSP90 inhibition.
Cytotoxicity and expression of genes involved in the cellular stress response and apoptosis in mammalian fibroblast exposed to cotton cellulose nanofibers.
Reverse phase protein array profiling reveals distinct proteomic signatures associated with chronic myeloid leukemia progression and with chronic phase in the CD34-positive compartment.
Leukemia, Erythroblastic, Acute
Activation of heat shock factor 2 during hemin-induced differentiation of human erythroleukemia cells.
Antiproliferative prostaglandins activate heat shock transcription factor.
Contribution of heat shock proteins to cell protection from complement-mediated lysis.
Cooperation between Hsp90 and mortalin/GRP75 in resistance to cell death induced by complement C5b-9.
Correlation between HSP90 induction kinetics in murine leukemia cells and the amount of cisplatin over a wide range of cytostatic concentrations.
Hemin-induced transcriptional activation of the HSP70 gene during erythroid maturation in K562 cells is due to a heat shock factor-mediated stress response.
Mortalin/Grp75 Binds to Complement C9 and Plays a Role in Resistance to Complement-Dependent Cytotoxicity.
Prostaglandins with antiproliferative activity induce the synthesis of a heat shock protein in human cells.
Reduction of Thermotolerance by Heat Shock Protein 90 Inhibitors in Murine Erythroleukemia Cells.
Leukemia, Lymphocytic, Chronic, B-Cell
17-DMAG targets the NF-{kappa}B family of proteins to induce apoptosis in CLL: clinical implications of HSP90 inhibition.
A phase I trial of the intravenous Hsp90 inhibitor alvespimycin (17-DMAG) in patients with relapsed chronic lymphocytic leukemia/small lymphocytic lymphoma.
Abundance of heat shock proteins (hsp89, hsp60, and hsp27) in malignant cells of Hodgkin's disease.
Association of GRP78, HIF-1? and BAG3 Expression with the Severity of Chronic Lymphocytic Leukemia.
Differential heat shock protein localization in chronic lymphocytic leukemia.
Expression of ERp5 and GRP78 on the membrane of chronic lymphocytic leukemia cells: association with soluble MICA shedding.
Geldanamycin and herbimycin A induce apoptotic killing of B chronic lymphocytic leukemia cells and augment the cells' sensitivity to cytotoxic drugs.
Heat shock protein-90 inhibitor, NVP-AUY922, is effective in combination with fludarabine against chronic lymphocytic leukemia cells cultured on CD40L-stromal layer and inhibits their activated/proliferative phenotype.
HSP70/HSF1 axis, regulated via a PI3K/AKT pathway, is a druggable target in chronic lymphocytic leukemia.
Hsp90 inhibition increases SOCS3 transcript and regulates migration and cell death in chronic lymphocytic leukemia.
Hsp90 Inhibitor SNX-7081 Dysregulates Proteins Involved with DNA Repair and Replication and the Cell Cycle in Human Chronic Lymphocytic Leukemia (CLL) Cells.
HSP90 overexpression potentiates the B-cell receptor and fibroblast growth factor receptor survival signals in chronic lymphocytic leukemia cells.
Molecular Pathways: GLI1-Induced Drug Glucuronidation in Resistant Cancer Cells.
Role of Specific B-Cell Receptor Antigens in Lymphomagenesis.
Targeting HSF1 disrupts HSP90 chaperone function in chronic lymphocytic leukemia.
The Hsp90 inhibitor SNX-7081 is synergistic with fludarabine nucleoside via DNA damage and repair mechanisms in human, p53-negative chronic lymphocytic leukemia.
The Hsp90 inhibitor SNX-7081 synergizes with and restores sensitivity to fludarabine in chronic lymphocytic leukemia cells with lesions in the TP53 pathway: a potential treatment strategy for fludarabine refractory disease.
TLR9-activating DNA up-regulates ZAP70 via sustained PKB induction in IgM+ B cells.
ZAP-70 is a novel conditional heat shock protein 90 (Hsp90) client: inhibition of Hsp90 leads to ZAP-70 degradation, apoptosis, and impaired signaling in chronic lymphocytic leukemia.
[Preparation of Heat Shock Protein 70 (Hsp70) and Idiotypic Determinant Single-chain Antibody (Id-ScFv) in a Patient with B-cell Chronic Lymphatic Leukemia (B-CLL) and Antitumor Effect of Peptide Complex Hsp70-Id.]
Leukemia, Lymphoid
Enhancement of immunogenicity of murine lymphocytic leukemia cells by transfection with BCG heat shock protein 70 gene.
Expression of heat-shock protein-90 in non-Hodgkin's lymphomas.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Activation of NK cells by extracellular heat shock protein 70 through induction of NKG2D ligands on dendritic cells.
Antileukemic activity of shepherdin and molecular diversity of hsp90 inhibitors.
Bag1 directly routes immature BCR-ABL for proteasomal degradation.
BCR-ABL point mutants isolated from patients with imatinib mesylate-resistant chronic myeloid leukemia remain sensitive to inhibitors of the BCR-ABL chaperone heat shock protein 90.
BJ-B11, a novel Hsp90 inhibitor, induces apoptosis in human chronic myeloid leukemia K562 cells through the mitochondria-dependent pathway.
C1206, a novel curcumin derivative, potently inhibits Hsp90 and human chronic myeloid leukemia cells in vitro.
CAMKII?, HSP70 and HSP90 transcripts are differentially expressed in chronic myeloid leukemia cells from patients with resistant mutated disease.
Celastrol, a novel HSP90 inhibitor, depletes Bcr-Abl and induces apoptosis in imatinib-resistant chronic myelogenous leukemia cells harboring T315I mutation.
Cell cycle arrest, apoptosis and autophagy induced by iminosugars on K562 cells.
Circulating heat shock protein 70 and progression in patients with chronic myeloid leukemia.
Combination of imatinib mesylate with autologous leukocyte-derived heat shock protein and chronic myelogenous leukemia.
Combination of JAK2 and HSP90 inhibitors: an effective therapeutic option in drug-resistant chronic myelogenous leukemia.
Combination of the histone deacetylase inhibitor LBH589 and the hsp90 inhibitor 17-AAG is highly active against human CML-BC cells and AML cells with activating mutation of FLT-3.
Extracellular heat shock protein 70: a potential prognostic marker for chronic myeloid leukemia.
Hot off the Press.
Hsp90 inhibitor, BIIB021, induces apoptosis and autophagy by regulating mTOR-Ulk1 pathway in imatinib-sensitive and -resistant chronic myeloid leukemia cells.
Hsp90 Inhibitors for the Treatment of Chronic Myeloid Leukemia.
Hsp90 N- and C-terminal double inhibition synergistically suppresses Bcr-Abl-positive human leukemia cells.
Modulation of Akt and ERK1/2 pathways by resveratrol in chronic myelogenous leukemia (CML) cells results in the downregulation of Hsp70.
Nonsteroidal Anti-inflammatory Drugs Sensitize CD44-Overexpressing Cancer Cells to Hsp90 Inhibitor Through Autophagy Activation.
Novel oxime derivatives of radicicol induce erythroid differentiation associated with preferential G(1) phase accumulation against chronic myelogenous leukemia cells through destabilization of Bcr-Abl with Hsp90 complex.
Overexpression of the heat-shock protein 70 is associated to imatinib resistance in chronic myeloid leukemia.
Sensitization of chemo-resistant human chronic myeloid leukemia stem-like cells to Hsp90 inhibitor by SIRT1 inhibition.
Targeting HSPA8 inhibits proliferation via downregulating BCR-ABL and enhances chemosensitivity in imatinib-resistant chronic myeloid leukemia cells.
Targeting of heat shock protein 32 (Hsp32)/heme oxygenase-1 (HO-1) in leukemic cells in chronic myeloid leukemia: a novel approach to overcome resistance against imatinib.
The heat shock protein 90 antagonist geldanamycin alters chaperone association with p210bcr-abl and v-src proteins before their degradation by the proteasome.
[Effect of Heat Stress on Expression of gp96 in K562 Cell Line of the Chronic Myeloid Leukemia and Its Significance.]
Leukemia, Myeloid
Expression and phosphorylation of BiP/GRP78, a molecular chaperone in the endoplasmic reticulum, during the differentiation of a mouse myeloblastic cell line.
Heat sensitivity, thermotolerance, and profile of heat shock protein synthesis of human myelogenous leukemias.
Heat shock protein 90 inhibition depletes TrkA levels and signaling in human acute leukemia cells.
Heat shock protein 90 regulates the expression of Wilms' tumor 1 protein in myeloid leukemias.
Hsp90 Inhibition Reduces TLR5 Surface Expression and NF-?B Activation in Human Myeloid Leukemia THP-1 Cells.
Human Cytomegalovirus Stimulates the Synthesis of Select Akt-Dependent Antiapoptotic Proteins during Viral Entry To Promote Survival of Infected Monocytes.
Human mortalin (HSPA9): a candidate for the myeloid leukemia tumor suppressor gene on 5q31.
Low-dose irradiation induces expression of heat shock protein 70 mRNA and thermo- and radio-resistance in myeloid leukemia cell line.
Oxidative stress induces monocyte necrosis with enrichment of cell-bound albumin and overexpression of endoplasmic reticulum and mitochondrial chaperones.
The driver of malignancy in KG-1a leukemic cells, FGFR1OP2-FGFR1, encodes an HSP90 addicted oncoprotein.
Weak electromagnetic fields (50 Hz) elicit a stress response in human cells.
Leukemia, Myeloid, Acute
A Hyperactive Signalosome in Acute Myeloid Leukemia Drives Addiction to a Tumor-Specific Hsp90 Species.
Antileukemic activity of shepherdin and molecular diversity of hsp90 inhibitors.
Calreticulin exposure by malignant blasts correlates with robust anticancer immunity and improved clinical outcome in AML patients.
Cytotoxic activity to acute myeloid leukemia cells by Antp-TPR hybrid peptide targeting Hsp90.
Disease-stabilizing treatment with all-trans retinoic acid and valproic acid in acute myeloid leukemia: Serum hsp70 and hsp90 levels and serum cytokine profiles are determined by the disease, patient age, and anti-leukemic treatment.
Emphasizing on heat shock protein 90's utility in head and neck squamous cell carcinoma treatment.
Expression of heat shock protein 70 and NKG2D ligands in acute myeloid leukemia cell lines.
GRP94 rewires and buffers the FLT3-ITD signaling network and promotes survival of acute myeloid leukemic stem cells.
Heat shock protein 90 - a potential target in the treatment of human acute myelogenous leukemia.
Heat shock protein 90 inhibition sensitizes acute myelogenous leukemia cells to cytarabine.
Heat shock protein 90 inhibitors overcome the resistance to Fms-like tyrosine kinase 3 inhibitors in acute myeloid leukemia.
High HSPA8 expression predicts adverse outcomes of acute myeloid leukemia.
Homoharringtonine Combined with the Heat Shock Protein 90 Inhibitor IPI504 in the Treatment of FLT3-ITD Acute Myeloid Leukemia.
HSP27 protects AML cells against VP-16-induced apoptosis through modulation of p38 and c-Jun.
HSP90 inhibition depletes DNA repair proteins to sensitize acute myelogenous leukemia to nucleoside analog chemotherapeutics.
Hsp90 inhibitor induces KG-1a cell differentiation and apoptosis via Akt/NF-?B signaling.
Hsp90/C terminal Hsc70-interacting protein regulates the stability of Ikaros in acute myeloid leukemia cells.
Humanization of a mouse monoclonal antibody directed against a cell surface-exposed epitope of membrane-associated heat shock protein 70 (Hsp70).
Immunogenic apoptosis in human acute myeloid leukemia (AML): primary human AML cells expose calreticulin and release heat shock protein (HSP) 70 and HSP90 during apoptosis.
Impact of the expression of P glycoprotein, the multidrug resistance-related protein, bcl-2, mutant p53, and heat shock protein 27 on response to induction therapy and long-term survival in patients with de novo acute myeloid leukemia.
Increased antileukemic effects in human acute myeloid leukemia by combining HSP70 and HSP90 inhibitors.
Inducible knockout of GRP78/BiP in the hematopoietic system suppresses Pten-null leukemogenesis and AKT oncogenic signaling.
Membrane-bound heat shock protein 70 (Hsp70) in acute myeloid leukemia: a tumor specific recognition structure for the cytolytic activity of autologous NK cells.
Pharmacokinetics and dose escalation of the heat shock protein inhibitor 17-allyamino-17-demethoxygeldanamycin in combination with bortezomib in relapsed or refractory acute myeloid leukemia.
Phase I study of the heat shock protein 90 inhibitor alvespimycin (KOS-1022, 17-DMAG) administered intravenously twice weekly to patients with acute myeloid leukemia.
Proliferation of hematopoietic cells is accompanied by suppressed expression of heat shock protein 70.
Selective KIT inhibitor KI-328 and HSP90 inhibitor show different potency against the type of KIT mutations recurrently identified in acute myeloid leukemia.
Stress-induced in vitro apoptosis of native human acute myelogenous leukemia (AML) cells shows a wide variation between patients and is associated with low BCL-2:Bax ratio and low levels of heat shock protein 70 and 90.
Study of heat shock protein HSP90 alpha, HSP70, HSP27 mRNA expression in human acute leukemia cells.
Superior activity of the combination of histone deacetylase inhibitor LAQ824 and the FLT-3 kinase inhibitor PKC412 against human acute myelogenous leukemia cells with mutant FLT-3.
Synergism between arsenic trioxide and heat shock protein 90 inhibitors on signal transducer and activator of transcription protein 3 activity--pharmacodynamic drug-drug interaction modeling.
Targeting on glycosylation of mutant FLT3 in acute myeloid leukemia.
The HSP90 inhibitor ganetespib: A potential effective agent for Acute Myeloid Leukemia in combination with cytarabine.
The novel HSP90 inhibitor NVP-AUY922 shows synergistic anti-leukemic activity with cytarabine in vivo.
Leukemia, Promyelocytic, Acute
HSP90 inhibitor 17AAG causes apoptosis in ATRA-resistant acute promyelocytic leukemia cells.
Leukemia, T-Cell
Anti-proliferative activity of heat shock protein (Hsp) 90 inhibitors via beta-catenin/TCF7L2 pathway in adult T cell leukemia cells.
HSP90 protects the human T-cell leukemia virus type 1 (HTLV-1) tax oncoprotein from proteasomal degradation to support NF-?B activation and HTLV-1 replication.
Human T cell leukemia virus type 1 Tax associates with a molecular chaperone complex containing hTid-1 and Hsp70.
Identification of novel lipid droplet factors that regulate lipophagy and cholesterol efflux in macrophage foam cells.
Inhibition of heat shock protein-90 modulates multiple functions required for survival of human T-cell leukemia virus type I-infected T-cell lines and adult T-cell leukemia cells.
The synthetic peptide P-197 inhibits human T-cell leukemia virus type 1 envelope-mediated syncytium formation by a mechanism that is independent of Hsc70.
Leukemia-Lymphoma, Adult T-Cell
Efficiency of AUY922 in mice with adult T-cell leukemia/lymphoma.
Heat shock protein 90 inhibitor NVP-AUY922 exerts potent activity against adult T-cell leukemia-lymphoma cells.
Inhibition of heat shock protein-90 modulates multiple functions required for survival of human T-cell leukemia virus type I-infected T-cell lines and adult T-cell leukemia cells.
Leukocytosis
Dietary supplementation of brown seaweed (Sargassum latifolium) alleviates the environmental heat stress-induced toxicity in male Barki sheep (Ovis aries).
Dietary supplementation of Sargassum latifolium modulates thermo-respiratory response, inflammation, and oxidative stress in bacterial endotoxin-challenged male Barki sheep.
Leukodystrophy, Metachromatic
Evaluating the role of ARSA in Chinese patients with Parkinson's disease.
Leukopenia
Epidemiology, genetic variants and clinical course of natural infections with Anaplasma phagocytophilum in a dairy cattle herd.
Molecular pathogenesis of myelodysplastic syndromes with deletion 5q.
Leukoplakia
Heat shock protein (HSP70) as a marker of epithelial dysplasia in oral dysplastic lesions: A clinicopathological study.
Positive association of glucose-regulated protein 78 during oral cancer progression and the prognostic value in oral precancerous lesions.
[Studies of heat shock protein 60 and heat shock protein 70 in oral lichen planus]
Leukoplakia, Oral
Detection of salivary heat shock protein 27 by enzyme-linked immunosorbent assay and its correlation with histopathology of oral leukoplakia.
Lewy Body Disease
Chaperone and anti-chaperone: two-faced synuclein as stimulator of synaptic evolution.
Leydig Cell Tumor
The rat 78,000 dalton glucose-regulated protein (GRP78) as a precursor for the rat steroidogenesis-activator polypeptide (SAP): the SAP coding sequence is homologous with the terminal end of GRP78.
Li-Fraumeni Syndrome
Hsp90 and PKM2 Drive the Expression of Aromatase in Li-Fraumeni Syndrome Breast Adipose Stromal Cells.
Withdrawal: Hsp90 and PKM2 drive the expression of aromatase in Li-Fraumeni syndrome breast adipose stromal cells.
Lichen Planus, Oral
Expression of heat shock protein (HSP70) in oral lichen planus and non-dysplastic oral leucoplakia.
Heat shock protein expression in oral lichen planus.
Immunohistochemical analyses of survivin and heat shock protein 90 expression in patients with oral lichen planus.
Oral lichen planus: an immunohistochemical study of heat shock proteins (HSPs) and cytokeratins (CKs) and a unifying hypothesis of pathogenesis.
[Studies of heat shock protein 60 and heat shock protein 70 in oral lichen planus]
Liposarcoma
Acceleration of TDP43 and FUS/TLS protein expressions in the preconditioned hippocampus following repeated transient ischemia.
HSP90 inhibition blocks ERBB3 and RET phosphorylation in myxoid/round cell liposarcoma and causes massive cell death in vitro and in vivo.
Hsp90 inhibition by AUY922 as an effective treatment strategy against myxoid liposarcoma.
Tumor Suppression Efficacy of Heat Shock Protein 90 Inhibitor 17AAG in a Liposarcoma Mouse Model.
Liposarcoma, Myxoid
Hsp90 inhibition by AUY922 as an effective treatment strategy against myxoid liposarcoma.
Immunohistochemical Analysis of Expressions of RB1, CDK4, HSP90, cPLA2G4A, and CHMP2B Is Helpful in Distinction between Myxofibrosarcoma and Myxoid Liposarcoma.
Lissencephaly
NudCL2 regulates cell migration by stabilizing both myosin-9 and LIS1 with Hsp90.
Listeriosis
Evidence for the early recruitment of T-cell receptor gamma delta+ T cells during rat listeriosis.
Listeria monocytogenes Uses LAP to Promote Bacterial Transepithelial Translocation, and Induces Expression of LAP Receptor Hsp60.
The regulatory role of heat shock protein 70-reactive CD4+ T cells during rat listeriosis.
Liver Abscess, Amebic
Obtaining of three recombinant antigens of Entamoeba histolytica and evaluation of their immunogenic ability without adjuvant in a hamster model of immunoprotection.
Liver Cirrhosis
An Intronic Variant in the GRP78, a Stress-Associated Gene, Improves Prediction for Liver Cirrhosis in Persistent HBV Carriers.
Chaperone-mediated autophagy compensates for impaired macroautophagy in the cirrhotic liver to promote hepatocellular carcinoma.
Circulating mortalin autoantibody--a new serological marker of liver cirrhosis.
Enhanced expression of glucose-regulated protein 78 correlates with malondialdehyde levels during the formation of liver cirrhosis in rats.
Express ELISA for detection of mortalin.
Gambogic acid attenuates liver fibrosis by inhibiting the PI3K/AKT and MAPK signaling pathways via inhibiting HSP90.
Geranylgeranylacetone attenuates hepatic fibrosis by increasing the expression of heat shock protein 70.
Heat shock protein 47 as indispensible participant in liver fibrosis: Possible protective effect of lactoferrin.
Heat shock protein 47 effects on hepatic stellate cell-associated receptors in hepatic fibrosis of Schistosoma japonicum-infected mice.
Heat shock protein 70 serum levels differ significantly in patients with chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma.
Identification of molecular markers for the oncogenic differentiation of hepatocellular carcinoma.
Increased expression of 78 kD glucose-regulated protein promotes cardiomyocyte apoptosis in a rat model of liver cirrhosis.
Inhibition of hepatic stellate cell proliferation by heat shock protein 90 inhibitors in vitro.
Involvement of heat shock protein 47 in Schistosoma japonicum-induced hepatic fibrosis in mice.
O-GlcNAcylation-dependent upregulation of HO1 triggers ammonia-induced oxidative stress and senescence in hepatic encephalopathy.
The heat shock protein 90 inhibitor, 17-AAG, attenuates thioacetamide induced liver fibrosis in mice.
TRAIL regulates collagen production through HSF1-dependent Hsp47 expression in activated hepatic stellate cells.
[Effect and mechanism of total flavonoids of Lichi Semen on CCl_4-induced liver fibrosis in rats, and prediction of Q-marker].
Liver Cirrhosis, Biliary
Antibodies to mycobacterial 65-kD heat shock protein cross-react with the main mitochondrial antigens in patients with primary biliary cirrhosis.
Autoantibody against 70 kD heat shock protein in patients with autoimmune liver diseases.
Disease-specific cross-reactivity between mimicking peptides of heat shock protein of Mycobacterium gordonae and dominant epitope of E2 subunit of pyruvate dehydrogenase is common in Spanish but not British patients with primary biliary cirrhosis.
Endothelial nitric oxide synthase regulation is altered in pancreas from cirrhotic rats.
Immuno-gold electron microscopical detection of heat shock protein 60 (hsp60) in mitochondria of rat hepatocytes and myocardiocytes.
Sequence homologies between hsp60 and autoantigens.
Liver Diseases
Alcohol-induced Hsp90 acetylation is a novel driver of liver sinusoidal endothelial dysfunction and alcohol-related liver disease.
Autoantibody against 70 kD heat shock protein in patients with autoimmune liver diseases.
Biliary expression of heat shock protein: a non-specific feature of chronic cholestatic liver diseases.
Changes in tumor necrosis factor-?, heat shock protein 70, malondialdehyde, and superoxide dismutase in patients with different severities of alcoholic fatty liver disease: a prospective observational study.
Circulating Hsp90 Isoform Levels in Overweight and Obese Children and the Relation to Nonalcoholic Fatty Liver Disease: Results from a Cross-Sectional Study.
Circulating IgA antibody against a 65 kDa heat shock protein in acute alcoholic hepatitis.
Expression of P53 and HSP70 in Chronic Hepatitis, Liver Cirrhosis, and Early and Advanced Hepatocellular Carcinoma Tissues and Their Diagnostic Value in Hepatocellular Carcinoma: An Immunohistochemical Study.
Heat shock protein 90 inhibitor induces apoptosis and attenuates activation of hepatic stellate cells.
Hsp90 modulates PPAR? activity in a mouse model of nonalcoholic fatty liver disease.
Inhibition of heat shock protein 90 alleviates steatosis and macrophage activation in murine alcoholic liver injury.
Inhibition of HSP90? Improves Lipid Disorders by Promoting Mature SREBPs Degradation via the Ubiquitin-proteasome System.
Liver-specific loss of glucose-regulated protein 78 perturbs the unfolded protein response and exacerbates a spectrum of liver diseases in mice.
Pancreastatin inhibitor activates AMPK pathway via GRP78 and ameliorates dexamethasone induced fatty liver disease in C57BL/6 mice.
Role of Exogenous Hsp72 on Liver Dysfunction during Sepsis.
Role of interleukin-6 in hepatic heat shock protein expression and protection against acetaminophen-induced liver disease.
Silymarin attenuated nonalcoholic fatty liver disease through the regulation of endoplasmic reticulum stress proteins GRP78 and XBP-1 in mice.
The effects of long-duration, low-temperature ground transportation on physiological and biochemical indicators of stress in mice.
The ménage à trois of autophagy, lipid droplets and liver disease.
Liver Diseases, Alcoholic
Circulating IgA antibody against a 65 kDa heat shock protein in acute alcoholic hepatitis.
Extracellular vesicles from mice with alcoholic liver disease carry a distinct protein cargo and induce macrophage activation via Hsp90.
Immunocytochemical detection of the 70-kd heat shock protein in alcoholic liver disease.
Inhibition of heat shock protein 90 alleviates steatosis and macrophage activation in murine alcoholic liver injury.
Modification of heat shock protein 90 by 4-hydroxynonenal in a rat model of chronic alcoholic liver disease.
Oxidative stress-mediated aldehyde adduction of GRP78 in a mouse model of alcoholic liver disease: functional independence of ATPase activity and chaperone function.
Liver Failure
Heat shock protein 70 genotypes HSPA1B and HSPA1L influence cytokine concentrations and interfere with outcome after major injury.
HSP60 and CpG-DNA-oligonucleotides differentially regulate LPS-tolerance of hepatic Kupffer cells.
Liver Neoplasms
15-Lipoxygenase-1/15-hydroxyeicosatetraenoic acid promotes hepatocellular cancer cells growth through protein kinase B and heat shock protein 90 complex activation.
Association of mortalin (HSPA9) with liver cancer metastasis and prediction for early tumor recurrence.
Biological characteristics of heat shock protein 90 in human liver cancer cells.
Circulating mortalin autoantibody--a new serological marker of liver cirrhosis.
Down-regulation of Hsp90 could change cell cycle distribution and increase drug sensitivity of tumor cells.
Expression of mortalin detected in human liver cancer by tissue microarrays.
Ganetespib radiosensitization for liver cancer therapy.
Gel-based proteomics of liver cancer progression in rat.
Glucose-regulated protein 78 demonstrates antiviral effects but is more suitable for hepatocellular carcinoma prevention in hepatitis B.
Granulin-epithelin precursor interacts with 78-kDa glucose-regulated protein in hepatocellular carcinoma.
GRP78 as a regulator of liver steatosis and cancer progression mediated by loss of the tumor suppressor PTEN.
Heat shock protein 90 inhibition abrogates hepatocellular cancer growth through cdc2-mediated G(2)/M cell cycle arrest and apoptosis.
Heat shock protein gp96 decreases p53 stability by regulating Mdm2 E3 ligase activity in liver cancer.
HSP90 and SIRT3 expression in hepatocellular carcinoma and their effect on invasive capability of human hepatocellular carcinoma cells.
Hsp90 transcriptionally and post-translationally regulates the expression of NDRG1 and maintains the stability of its modifying kinase GSK3beta.
Identification of the Differential Expression Profiles of Serum and Tissue Proteins During Rat Hepatocarcinogenesis.
Immunogenic Cell Death (ICD) of Murine H22 Cells Induced by Lentinan.
Inhibition of heat-shock protein 90 sensitizes liver cancer stem-like cells to magnetic hyperthermia and enhances anti-tumor effect on hepatocellular carcinoma-burdened nude mice.
Mild Magnetic Hyperthermia-Activated Innate Immunity for Liver Cancer Therapy.
Plasma Heat Shock Protein 90alpha as a Biomarker for the Diagnosis of Liver Cancer: An Official, Large-scale, and Multicenter Clinical Trial.
Plasma heat shock protein 90alpha as a biomarker for the diagnosis of liver cancer: in patients with different clinicopathologic characteristics.
Radiofrequency ablation, heat shock protein 70 and potential anti-tumor immunity in hepatic and pancreatic cancers: a minireview.
Role of HSP90, CDC37, and CRM1 as modulators of P16(INK4A) activity in rat liver carcinogenesis and human liver cancer.
Solid-phase synthesis, characterization and RNAi activity of branch and hyperbranch siRNAs.
Targeting GRP75 improves HSP90 inhibitor efficacy by enhancing p53-mediated apoptosis in hepatocellular carcinoma.
The apoptotic effect and associated signalling of HSP90 inhibitor 17-DMAG in hepatocellular carcinoma cells.
The mitochondrial chaperone Prohibitin 1 negatively regulates interleukin-8 in human liver cancers.
The Molecular Chaperone HSP70 Controls Liver Cancer Initiation and Progression by Regulating Adaptive DNA-Damage and MAPK/ERK Signaling Pathways.
[Regulatory mechanism of heat shock protein 90 on autophagy-related transcription factor EB in human hepatocellular carcinoma cells].
Liver Neoplasms, Experimental
Comparative proteomics of rat liver and Morris hepatoma 7777 plasma membranes.
Long QT Syndrome
Heat shock protein 70 gene polymorphisms' influence on the electrophysiology of long QT syndrome.
Low Tension Glaucoma
Antibodies to alpha B-crystallin, vimentin, and heat shock protein 70 in aqueous humor of patients with normal tension glaucoma and IgG antibody patterns against retinal antigen in aqueous humor.
Lung Diseases
Activation of the plasma kallikrein-kinin system on human lung epithelial cells.
Anti-citrullinated heat shock protein 90 antibodies identified in bronchoalveolar lavage fluid are a marker of lung-specific immune responses.
Expression of heme oxygenase-1 in type II pneumocytes protects against heatstroke-induced lung damage.
Hsp90 regulation of fibroblast activation in pulmonary fibrosis.
Immunolocalization of collagen and collagen-binding heat shock protein 47 in fibrotic lung diseases.
Serum heat shock protein 47 levels in patients with drug-induced lung disease.
Lung Diseases, Interstitial
Anti-citrullinated heat shock protein 90 antibodies identified in bronchoalveolar lavage fluid are a marker of lung-specific immune responses.
Autoreactive T cells to citrullinated HSP90 are associated with interstitial lung disease in rheumatoid arthritis.
Extensive Citrullination Promotes Immunogenicity of HSP90 through Protein Unfolding and Exposure of Cryptic Epitopes.
Identification of citrullinated heat shock protein 90 isoforms as novel autoantigens in rheumatoid arthritis-associated interstitial lung disease.
Spontaneous heat shock protein synthesis by alveolar macrophages in interstitial lung disease associated with phagocytosis of eosinophils.
Lung Injury
Carbon monoxide protects against ventilator-induced lung injury via PPAR-gamma and inhibition of Egr-1.
Do we kNOw how HSP90 and eNOS mediate lung injury in sickle cell disease?
Enhanced expression of 70-kilodalton heat shock protein limits cell division in a sepsis-induced model of acute respiratory distress syndrome.
Enhanced Hsp70 expression protects against acute lung injury by modulating apoptotic pathways.
Glutamine attenuates lung injury and improves survival after sepsis: role of enhanced heat shock protein expression.
Glutamine's protection against sepsis and lung injury is dependent on heat shock protein 70 expression.
GRP78 and CHOP modulate macrophage apoptosis and the development of bleomycin-induced pulmonary fibrosis.
Heat shock protein 70 as an indicator of early lung injury caused by exposure to arsenic.
Heat shock protein 90 inhibitors attenuate LPS-induced endothelial hyperpermeability.
Heat shock protein 90 inhibitors prolong survival, attenuate inflammation, and reduce lung injury in murine sepsis.
High-altitude pulmonary edema can be prevented by heat shock protein 70-mediated hyperbaric oxygen preconditioning.
Hsp90 regulation affects the treatment of glucocorticoid for pancreatitis-induced lung injury.
Post-treatment with a heat shock protein 90 inhibitor prevents chronic lung injury and pulmonary fibrosis, following acute exposure of mice to HCl.
Postoperative remote lung injury and its impact on surgical outcome.
Prophylactic inhalation of L-alanyl-L-glutamine enhances heat shock protein 72 and attenuates endotoxin-induced lung injury in rats.
Protocatechuic acid attenuates lipopolysaccharide-induced septic lung injury in mice: The possible role through suppressing oxidative stress, inflammation and apoptosis.
Pyrrolidine dithiocarbamate reduces lung reperfusion injury.
Regulation of iNOS-Derived ROS Generation by HSP90 and Cav-1 in Porcine Reproductive and Respiratory Syndrome Virus-Infected Swine Lung Injury.
Secretion of the endoplasmic reticulum stress protein, GRP78, into the BALF is increased in cigarette smokers.
Somatostatin Reduces the Acute Lung Injury of Mice via Increasing the Affinity of Glucocorticoid Receptor.
The HSP90 Inhibitor, AUY-922, Ameliorates the Development of Nitrogen Mustard-Induced Pulmonary Fibrosis and Lung Dysfunction in Mice.
Thermotolerance induces heat shock protein 72 expression and protects against ischaemia-reperfusion-induced lung injury.
Treatment with Geranylgeranylacetone Induces Heat Shock Protein 70 and Attenuates Neonatal Hyperoxic Lung Injury in a Model of Bronchopulmonary Dysplasia.
[Relationship between the expression of heat shock protein 25 and selenium binding protein 1 with ischemia/reperfusion lung injury in vivo: experiment with rats]
Lung Neoplasms
17-AAG Enhances PS-341-Induced Lung Cancer Cell Death by Blocking the NF-?B and PI3K/Akt Pathways.
17-DMAG-loaded nanofibrous scaffold for effective growth inhibition of lung cancer cells through targeting HSP90 gene expression.
19P Comparative effectiveness analysis of HSP90 inhibitors in non-small cell lung cancer.
3-O-(Z)-coumaroyloleanolic acid overcomes Cks1b-induced chemoresistance in lung cancer by inhibiting Hsp90 and MEK pathways.
A Novel HSP90 Inhibitor-Drug Conjugate to SN38 Is Highly Effective in Small Cell Lung Cancer.
A randomized phase II study of ganetespib, a heat shock protein 90 inhibitor, in combination with docetaxel in second-line therapy of advanced non-small cell lung cancer (GALAXY-1).
A Randomized, Double-Blinded, Phase II Trial of Carboplatin and Pemetrexed with or without Apatorsen (OGX-427) in Patients with Previously Untreated Stage IV Non-Squamous-Non-Small-Cell Lung Cancer: The SPRUCE Trial.
Activity of HSP90 Inhibiton in a Metastatic Lung Cancer Patient With a Germline BRCA1 Mutation.
Activity of IPI-504, a Novel Heat-Shock Protein 90 Inhibitor, in Patients With Molecularly Defined Non-Small-Cell Lung Cancer.
Activity of the Hsp90 inhibitor luminespib among non-small-cell lung cancers harboring EGFR exon 20 insertions.
Akt is the downstream target of GRP78 in mediating cisplatin resistance in ER stress-tolerant human lung cancer cells.
An intronic polymorphism in GRP78 improves chemotherapeutic prediction in non-small-cell lung cancer.
Anti-tumor selectivity of a novel tubulin and HSP90 dual-targeting inhibitor in non-small cell lung cancer models.
Antibodies to HSP70 and HSP90 in serum in non-small cell lung cancer patients.
Antibody Targeting GRP78 Enhances the Efficacy of Radiation Therapy in Human Glioblastoma and Non-Small Cell Lung Cancer Cell Lines and Tumor Models.
Anticancer activity of methylene blue via inhibition of heat shock protein 70.
Argpyrimidine-modified Heat shock protein 27 in human non-small cell lung cancer: a possible mechanism for evasion of apoptosis.
Aspirin potentiates celecoxib-induced growth inhibition and apoptosis in human non-small cell lung cancer by targeting GRP78 activity.
Author Correction: Targeting Hsp90 with FS-108 circumvents gefitinib resistance in EGFR mutant non-small cell lung cancer cells.
Autoantibody to heat shock protein Hsp40 in sera of lung cancer patients.
AUY922 effectively overcomes MET- and AXL-mediated resistance to EGFR-TKI in lung cancer cells.
Cancer Associated Fibroblast-Derived Hepatocyte Growth Factor Inhibits the Paclitaxel-Induced Apoptosis of Lung Cancer A549 Cells by Up-Regulating the PI3K/Akt and GRP78 Signaling on a Microfluidic Platform.
Cancer-associated fibroblasts promote non-small cell lung cancer cell invasion by upregulation of glucose-regulated protein 78 (GRP78) expression in an integrated bionic microfluidic device.
Celastrol induces apoptosis in gefitinib-resistant non-small cell lung cancer cells via caspases-dependent pathways and Hsp90 client protein degradation.
Celecoxib induces cell death on non-small cell lung cancer cells through endoplasmic reticulum stress.
Cell death induced by down-regulation of heat shock protein 70 in lung cancer cell lines is p53-independent and does not require DNA cleavage.
Chalcone-templated Hsp90 inhibitors and their effects on gefitinib resistance in non-small cell lung cancer (NSCLC).
Chaperonin (HSP60) and annexin-2 are candidate biomarkers for non-small cell lung carcinoma.
Chaperoning cell death: a critical dual role for Hsp90 in small-cell lung cancer.
Circulating GRP78 acts as a biomarker in the early diagnosis of lung cancer.
Circulating heat shock protein 27 as a biomarker for the differentiation of patients with lung cancer and healthy controls--a clinical comparison of different enzyme linked immunosorbent assays.
Circulating Heat Shock Protein 70 Is a Novel Biomarker for Early Diagnosis of Lung Cancer.
Clinicopathological and prognostic significance of heat shock protein 27 (HSP27) expression in non-small cell lung cancer: a systematic review and meta-analysis.
Combination of heat shock protein 90 and focal adhesion kinase inhibitors synergistically inhibits the growth of non-small cell lung cancer cells.
Combined inhibition of Hsp90 and the proteasome affects NSCLC proteostasis and attenuates cell migration.
Comparison of inhibitory effect of 17-DMAG nanoparticles and free 17-DMAG in HSP90 gene expression in lung cancer.
Complex Crystal Structure Determination and in vitro Anti-non-small Cell Lung Cancer Activity of Hsp90 N Inhibitor SNX-2112.
Contributions of co-chaperones and post-translational modifications towards Hsp90 drug sensitivity.
Correlation of Hsp70 Serum Levels with Gross Tumor Volume and Composition of Lymphocyte Subpopulations in Patients with Squamous Cell and Adeno Non-Small Cell Lung Cancer.
Corrigendum to "Panaxynol, a natural Hsp90 inhibitor, effectively targets both lung cancer stem and non-stem cells" [Canc. Lett. 412 (2018) 297-307].
Corrigendum to"Isoindoline scaffold-based dual inhibitors of HDAC6 and HSP90 suppressing the growth of lung cancer in vitro and in vivo"[Eur. J. Med. Chem. 190 (2020 Mar 15) 112086].
Deciphering the Inhibition Mechanism of under Trial Hsp90 Inhibitors and Their Analogues: A Comparative Molecular Dynamics Simulation.
Decoding c-Myc networks of cell cycle and apoptosis regulated genes in a transgenic mouse model of papillary lung adenocarcinomas.
Design, synthesis and pharmacological evaluation of 4,5-diarylisoxazols bearing amino acid residues within the 3-amido motif as potent heat shock protein 90 (Hsp90) inhibitors.
Design, Synthesis and Pharmacological Evaluation of Novel Hsp90N-terminal Inhibitors Without Induction of Heat Shock Response.
Development of a high-throughput screening cancer cell-based luciferase refolding assay for identifying Hsp90 inhibitors.
Development of a novel Hsp90 inhibitor NCT-50 as a potential anticancer agent for the treatment of non-small cell lung cancer.
Differential expression of heat shock protein 90 isoforms in small cell lung cancer.
Differential mitochondrial proteome analysis of human lung adenocarcinoma and normal bronchial epithelium cell lines using quantitative mass spectrometry.
Differentially expressed genes associated with human lung cancer.
Direct targeting of HSP90 with daurisoline destabilizes ?-catenin to suppress lung cancer tumorigenesis.
Discovery of 2',4'-dimethoxychalcone as a Hsp90 inhibitor and its effect on iressa-resistant non-small cell lung cancer (NSCLC).
Discovery of hybrid Hsp90 inhibitors and their anti-neoplastic effects against gefitinib-resistant non-small cell lung cancer (NSCLC).
Discovery of novel HSP90 inhibitors that induced apoptosis and impaired autophagic flux in A549 lung cancer cells.
Disseminated Tumor Cells Persist in the Bone Marrow of Breast Cancer Patients through Sustained Activation of the Unfolded Protein Response.
Distinct prognostic roles of HSPB1 expression in non-small cell lung cancer.
Down-regulation of cellular FLICE-inhibitory protein (Long Form) contributes to apoptosis induced by Hsp90 inhibition in human lung cancer cells.
Down-regulation of ERK1/2 and AKT-mediated X-ray repair cross-complement group 1 protein (XRCC1) expression by Hsp90 inhibition enhances the gefitinib-induced cytotoxicity in human lung cancer cells.
Down-regulation of GRP78 is associated with the sensitivity of chemotherapy to VP-16 in small cell lung cancer NCI-H446 cells.
Down-regulation of MSH2 expression by an Hsp90 inhibitor enhances pemetrexed-induced cytotoxicity in human non-small-cell lung cancer cells.
Down-regulation of MSH2 expression by Hsp90 inhibition enhances cytotoxicity affected by tamoxifen in human lung cancer cells.
Downregulation of Xeroderma Pigmentosum Complementation Group C Expression by 17-Allylamino-17-Demethoxygeldanamycin Enhances Bevacizumab-Induced Cytotoxicity in Human Lung Cancer Cells.
Drug-Like Small Molecule HSP27 Functional Inhibitor Sensitizes Lung Cancer Cells to Gefitinib or Cisplatin by Inducing Altered Cross-Linked Hsp27 Dimers.
Dynamics of Heat Shock Protein 70 Serum Levels As a Predictor of Clinical Response in Non-Small-Cell Lung Cancer and Correlation with the Hypoxia-Related Marker Osteopontin.
Effect of BIS depletion on HSF1-dependent transcriptional activation in A549 non-small cell lung cancer cells.
Effect of the histone deacetylase inhibitor LBH589 against epidermal growth factor receptor-dependent human lung cancer cells.
Effects of a Unique Combination of the Whole-Body Low Dose Radiotherapy with Inactivation of Two Immune Checkpoints and/or a Heat Shock Protein on the Transplantable Lung Cancer in Mice.
Effects of Yiqi Chutan Tang on the Proteome in LEWIS Lung Cancer in Mice.
Emergence of resistance to tyrosine kinase inhibitors in non-small-cell lung cancer can be delayed by an upfront combination with the HSP90 inhibitor onalespib.
EML4-ALK fusions: propelling cancer but creating exploitable chaperone dependence.
Endoplasmic reticulum chaperone GRP78/BiP is critical for mutant Kras-driven lung tumorigenesis.
Endoplasmic reticulum ribosome-binding protein 1 (RRBP1) overexpression is frequently found in lung cancer patients and alleviates intracellular stress-induced apoptosis through the enhancement of GRP78.
Enhanced antitumor activity of erlotinib in combination with the Hsp90 inhibitor CH5164840 against non-small-cell lung cancer.
Enhancement of radiation sensitivity in lung cancer cells by celastrol is mediated by inhibition of Hsp90.
ER homeostasis and motility of NSCLC cell lines can be therapeutically targeted with combined Hsp90 and HDAC inhibitors.
ER residential chaperone GRP78 unconventionally relocalizes to the cell surface via endosomal transport.
ERGIC3 silencing additively enhances the growth inhibition of BFA on lung adenocarcinoma cells.
Expression of endoplasmic reticulum molecular chaperone Grp78 in human lung cancer and its clinical significance.
Expression of ER stress and autophagy-related molecules in human non-small cell lung cancer and premalignant lesions.
Expression of heat shock protein 70 and 27 in non-small cell lung cancer and its clinical significance.
Expression of heat shock protein 70 and p53 in human lung cancer.
Expression of resistance-related proteins in tumoral and peritumoral tissues of patients with lung cancer.
Expressions of GRP78 and Bax associate with differentiation, metastasis, and apoptosis in non-small cell lung cancer.
Functional promoter rs2868371 variant of HSPB1 associates with radiation-induced esophageal toxicity in patients with non-small-cell lung cancer treated with radio(chemo)therapy.
GALNT6 promotes invasion and metastasis of human lung adenocarcinoma cells through O-glycosylating chaperone protein GRP78.
Ganetespib (STA-9090), a Nongeldanamycin HSP90 Inhibitor, Has Potent Antitumor Activity in In Vitro and In Vivo Models of Non-Small Cell Lung Cancer.
Glucose-related protein (GRP78) and its relationship to the drug-resistance proteins P170, GST-pi, LRP56 and angiogenesis in non-small cell lung carcinomas.
GRP78 and Raf-1 cooperatively confer resistance to endoplasmic reticulum stress-induced apoptosis.
GRP78 in lung cancer.
GRP78 up-regulation leads to hypersensitization to cisplatin in A549 lung cancer cells.
GRP78 upregulation-induced increase in cisplatin sensitivity of SPCA1 lung cancer cells.
GRP78, intronic polymorphisms, and pharmacogenomics in non-small cell lung cancer.
Heat shock protein 27 promotes cell proliferation through activator protein-1 in lung cancer.
Heat Shock Protein 70 (Hsp70) Peptide Activated Natural Killer (NK) Cells for the Treatment of Patients with Non-Small Cell Lung Cancer (NSCLC) after Radiochemotherapy (RCTx) - From Preclinical Studies to a Clinical Phase II Trial.
Heat shock protein 70 as a predictive marker for platinum-based adjuvant chemotherapy in patients with resected non-small cell lung cancer.
Heat Shock Protein 90 (Hsp90) inhibitor occupancy is a direct determinant of client protein degradation and tumor growth arrest in vivo.
Heat shock protein 90 inhibition in lung cancer.
Heat shock protein 90 inhibitors in non-small-cell lung cancer.
Heat shock protein antagonists in early stage clinical trials for NSCLC.
Heat shock protein B6 potently increases non-small cell lung cancer growth.
Heat shock proteins as biomarkers of lung cancer.
Histone deacetylase, proteasome, and heat shock protein inhibitors for the treatment of lung cancer.
HLJ1 is a novel caspase-3 substrate and its expression enhances UV-induced apoptosis in non-small cell lung carcinoma.
Hsp60 and Hsp10 down-regulation predicts bronchial epithelial carcinogenesis in smokers with chronic obstructive pulmonary disease.
HSP90 as a novel molecular target in non-small-cell lung cancer.
HSP90 inhibition enhances antimitotic drug-induced mitotic arrest and cell death in preclinical models of non-small cell lung cancer.
HSP90 inhibition induces cytotoxicity via down-regulation of Rad51 expression and DNA repair capacity in non-small cell lung cancer cells.
Hsp90 inhibition overcomes HGF-triggering resistance to EGFR-TKIs in EGFR-mutant lung cancer by decreasing client protein expression and angiogenesis.
Hsp90 inhibition suppresses mutant EGFR-T790M signaling and overcomes kinase inhibitor resistance.
HSP90 inhibitor (NVP-AUY922) enhances the anti-cancer effect of BCL-2 inhibitor (ABT-737) in small cell lung cancer expressing BCL-2.
HSP90 inhibitor DPB induces autophagy and more effectively apoptosis in A549 cells combined with autophagy inhibitors.
Hsp90 Inhibitor Ganetespib Sensitizes Non-Small Cell Lung Cancer to Radiation but Has Variable Effects with Chemoradiation.
Hsp90 inhibitor gedunin causes apoptosis in A549 lung cancer cells by disrupting Hsp90:Beclin-1:Bcl-2 interaction and downregulating autophagy.
Hsp90 inhibitor NVP-AUY922 enhances the radiation sensitivity of lung cancer cell lines with acquired resistance to EGFR-tyrosine kinase inhibitors.
HSP90 inhibitor, DMAG, synergizes with radiation of lung cancer cells by interfering with base excision and ATM-mediated DNA repair.
Hsp90 inhibitors cause G2/M arrest associated with the reduction of Cdc25C and Cdc2 in lung cancer cell lines.
Hsp90 inhibitors enhance the antitumoral effect of osimertinib in parental and osimertinib-resistant non-small cell lung cancer cell lines.
HSP90 inhibitors in lung cancer: promise still unfulfilled.
HSP90 inhibitors in the context of heat shock and the unfolded protein response: effects on a primary canine pulmonary adenocarcinoma cell line.
HSP90/AXL/eIF4E-regulated unfolded protein response as an acquired vulnerability in drug-resistant KRAS-mutant lung cancer.
HSPB1 Gene Polymorphisms Predict Risk of Mortality for US Patients After Radio(chemo)therapy for Non-Small Cell Lung Cancer.
HSPB1 polymorphisms might be associated with radiation-induced damage risk in lung cancer patients treated with radiotherapy.
Human Genetic Relevance and Potent Antitumor Activity of Heat Shock Protein 90 Inhibition in Canine Lung Adenocarcinoma Cell Lines.
Ibuprofen enhances the anticancer activity of cisplatin in lung cancer cells by inhibiting the heat shock protein 70.
Induction of premature senescence by hsp90 inhibition in small cell lung cancer.
Inhibition of HSP90 molecular chaperones: moving into the clinic.
Inhibition of thymidine phosphorylase expression by Hsp90 inhibitor potentiates the cytotoxic effect of salinomycin in human non-small-cell lung cancer cells.
Inhibition of thymidine phosphorylase expression by using an HSP90 inhibitor potentiates the cytotoxic effect of cisplatin in non-small-cell lung cancer cells.
Integration of Gene Dosage and Gene Expression in Non-Small Cell Lung Cancer, Identification of HSP90 as Potential Target.
Intronic polymorphism (1541-1542delGT) of the constitutive heat shock protein 70 gene has functional significance and shows evidence of association with lung cancer risk.
Involvement of calcium in the differential induction of heat shock protein 70 by heat shock protein 90 inhibitors, geldanamycin and radicicol, in human non-small cell lung cancer H460 cells.
Involvement of collagen-binding heat shock protein 47 and procollagen type I synthesis in idiopathic pulmonary fibrosis: contribution of type II pneumocytes to fibrosis.
Isoindoline scaffold-based dual inhibitors of HDAC6 and HSP90 suppressing the growth of lung cancer in vitro and in vivo.
Liposomal encapsulation of deguelin: evidence for enhanced antitumor activity in tobacco carcinogen-induced and oncogenic K-ras-induced lung tumorigenesis.
Low-concentration HCP1 inhibits apoptosis in vascular endothelial cells.
Luminespib plus pemetrexed in patients with non-squamous non-small cell lung cancer.
Lung cancer: progression of heat shock protein 70 in association with flap endonuclease 1 protein.
Membrane phospholipids, EML4-ALK, and Hsp90 as novel targets in lung cancer treatment.
Metastasis and the Tumor Microenvironment: A Joint Metastasis Research Society-AACR Conference - Research on Metastasis: Part 2.
miR-199a-5p and miR-495 target GRP78 within UPR pathway of lung cancer.
Molecular Chaperone HSP90 Is Necessary to Prevent Cellular Senescence via Lysosomal Degradation of p14ARF.
Molecular mechanism and targeted therapy of Hsp90 involved in lung cancer: New discoveries and developments (Review).
Mortalin overexpression predicts poor prognosis in early stage of non-small cell lung cancer.
Nck-associated protein 1 associates with HSP90 to drive metastasis in human non-small-cell lung cancer.
New molecular targeted therapies integrated with radiation therapy in lung cancer.
Novel Hsp90 Inhibitor C086 Potently Inhibits Non-Small Cell Lung Cancer Cells As A Single Agent Or In Combination With Gefitinib.
Novel immunohistochemical monoclonal antibody against human glucose-regulated protein 78.
Nuclear Accumulation of Heat-shock Protein 90 Is Associated with Poor Survival and Metastasis in Patients with Non-small Cell Lung Cancer.
Oncolytic Newcastle disease virus induces autophagy-dependent immunogenic cell death in lung cancer cells.
Organ-specific efficacy of HSP90 inhibitor in multiple-organ metastasis model of chemorefractory small cell lung cancer.
Overcoming HSP27-mediated resistance by altered dimerization of HSP27 using small molecules.
Overexpression of endoplasmic reticulum molecular chaperone GRP94 and GRP78 in human lung cancer tissues and its significance.
Overexpression of heat shock protein 70 inhibits epithelial-mesenchymal transition and cell migration induced by transforming growth factor-? in A549 cells.
Overexpression of HSP10 correlates with HSP60 and Mcl-1 levels and predicts poor prognosis in non-small cell lung cancer patients.
P-glycoprotein confers acquired resistance to 17-DMAG in lung cancers with an ALK rearrangement.
P-glycoprotein-evading anti-tumor activity of a novel tubulin and HSP90 dual inhibitor in a non-small-cell lung cancer model.
Panaxynol, a natural Hsp90 inhibitor, effectively targets both lung cancer stem and non-stem cells.
Phase I/II Study of HSP90 Inhibitor AUY922 and Erlotinib for EGFR-Mutant Lung Cancer With Acquired Resistance to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors.
Pifithrin-? is efficacious against non-small cell lung cancer via inhibition of heat shock protein 70.
Plasma Heat Shock Protein 90 Alpha: A Valuable Predictor of Early Chemotherapy Effectiveness in Advanced Non-Small-Cell Lung Cancer.
Plasma levels of heat shock protein 90 alpha associated with lung cancer development and treatment responses.
Presence of heat shock protein 47-positive fibroblasts in cancer stroma is associated with increased risk of postoperative recurrence in patients with lung cancer.
Prognostic value of the mRNA expression of members of the HSP90 family in non-small cell lung cancer.
Progression of the role of CRYAB in signaling pathways and cancers.
Quantitative proteomics reveals molecular mechanism of gamabufotalin and its potential inhibition on Hsp90 in lung cancer.
Quercetin Enhances Chemosensitivity to Gemcitabine in Lung Cancer Cells by Inhibiting Heat Shock Protein 70 Expression.
Radiosensitization of HSF-1 Knockdown Lung Cancer Cells by Low Concentrations of Hsp90 Inhibitor NVP-AUY922.
Radiosensitization of human lung cancer cells by the novel purine-scaffold Hsp90 inhibitor, PU-H71.
Randomized Phase III Study of Ganetespib, a Heat Shock Protein 90 Inhibitor, With Docetaxel Versus Docetaxel in Advanced Non-Small-Cell Lung Cancer (GALAXY-2).
Receptor ligand-triggered resistance to alectinib and its circumvention by Hsp90 inhibition in EML4-ALK lung cancer cells.
Reversed expression of GRIM-1 and GRP78 in human non-small cell lung cancer.
Ring-opening of five-membered heterocycles conjugated 4-isopropylresorcinol scaffold-based benzamides as HSP90 inhibitors suppressing tumor growth in vitro and in vivo.
Secreted Heat Shock Protein 90? Attenuated the Effect of Anticancer Drugs in Small-Cell Lung Cancer Cells Through AKT/GSK3?/?-Catenin Signaling.
Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer.
Sensitization of lung cancer cells by altered dimerization of HSP27.
Serendipity and technical considerations for the measurement of serum heat shock protein HSP27 in patients with COPD and lung cancer.
Serum GRP78 as a Tumor Marker and Its Prognostic Significance in Non-Small Cell Lung Cancers: A Retrospective Study.
Serum heat shock protein 70 levels and lung cancer risk: a case-control study nested in a large cohort study.
Serum Heat Shock Protein 70, as a Potential Biomarker for Small Cell Lung Cancer.
Strong anti-tumor effect of NVP-AUY922, a novel Hsp90 inhibitor, on non-small cell lung cancer.
Synergistic activity of the Hsp90 inhibitor ganetespib with taxanes in non-small cell lung cancer models.
Targeted inhibition of GRP78 by HA15 promotes apoptosis of lung cancer cells accompanied by ER stress and autophagy.
Targeted Inhibition of the Molecular Chaperone Hsp90 Overcomes ALK Inhibitor Resistance in Non-Small Cell Lung Cancer.
Targeting heat shock protein 90 overrides the resistance of lung cancer cells by blocking radiation-induced stabilization of hypoxia-inducible factor-1alpha.
Targeting heat shock protein 90 with CUDC-305 overcomes erlotinib resistance in non-small cell lung cancer.
Targeting Hsp90 with FS-108 circumvents gefitinib resistance in EGFR mutant non-small cell lung cancer cells.
Targeting KRAS-mutant non-small cell lung cancer with the Hsp90 inhibitor ganetespib.
The analysis of chemotherapy resistance in human lung cancer cell line with microchip-based system.
The anti-cancer drug ABTL0812 induces ER stress-mediated cytotoxic autophagy by increasing dihydroceramide levels in cancer cells.
The anti-proliferative effect of heat shock protein 90 inhibitor, 17-DMAG, on non-small-cell lung cancers being resistant to EGFR tyrosine kinase inhibitor.
The combination of Hsp90 inhibitor 17AAG and heavy-ion irradiation provides effective tumor control in human lung cancer cells.
The deubiquitylase OTUD3 stabilizes GRP78 and promotes lung tumorigenesis.
The diagnostic value of tumor markers in bronchoalveolar lavage fluid for the peripheral pulmonary carcinoma.
The heat shock protein 90 inhibitor, AT13387, displays a long duration of action in vitro and in vivo in non-small cell lung cancer.
The HSP90 inhibitor ganetespib potentiates the antitumor activity of EGFR tyrosine kinase inhibition in mutant and wild-type non-small cell lung cancer.
The Hsp90 inhibitor IPI-504 rapidly lowers EML4-ALK levels and induces tumor regression in ALK-driven NSCLC models.
The HSP90 inhibitor NVP-AUY922 potently inhibits non-small cell lung cancer growth.
The HSP90 inhibitor, NVP-AUY922, attenuates intrinsic PI3K inhibitor resistance in KRAS-mutant non-small cell lung cancer.
The HSP90 inhibitor, NVP-AUY922, sensitizes KRAS-mutant non-small cell lung cancer with intrinsic resistance to MEK inhibitor, trametinib.
The platelet-derived growth factor receptor alpha is destabilized by geldanamycins in cancer cells.
The relationship between three heat shock protein 70 gene polymorphisms and susceptibility to lung cancer.
The targeted inhibition of Hsp90 by a synthetic small molecule, DPide offers an effective treatment strategy against TNBCs.
Treatment of colon and lung cancer patients with ex vivo heat shock protein 70-peptide-activated, autologous natural killer cells: a clinical phase i trial.
Tumor cell expression of heat shock protein (HSP) 72 is influenced by HSP72 [HSPA1B A(1267)G] polymorphism and predicts survival in small Cell lung cancer (SCLC) patients.
Tumor suppressor HLJ1 binds and functionally alters nucleophosmin via activating enhancer binding protein 2alpha complex formation.
Tumor-Intrinsic and Tumor-Extrinsic Factors Impacting Hsp90-Targeted Therapy.
Tumor-targeted SN38 inhibits growth of early stage non-small cell lung cancer (NSCLC) in a KRas/p53 transgenic mouse model.
Ubiquitin ligase CHIP regulates OTUD3 stability and suppresses tumour metastasis in lung cancer.
uc.454 Inhibited Growth by Targeting Heat Shock Protein Family A Member 12B in Non-Small-Cell Lung Cancer.
Upregulation of GRP78 and GRP94 and its function in chemotherapy resistance to VP-16 in human lung cancer cell line SK-MES-1.
Vaccination with TCL plus MHSP65 induces anti-lung cancer immunity in mice.
VDAC upregulation and ?TAT1?mediated ??tubulin acetylation contribute to tanespimycin?induced apoptosis in Calu?1 cells.
Vorinostat enhances gefitinib?induced cell death through reactive oxygen species?dependent cleavage of HSP90 and its clients in non?small cell lung cancer with the EGFR mutation.
VP-16 resistance in the NCI-H460 human lung cancer cell line is significantly associated with glucose-regulated protein78 (GRP78) induction.
[Down-regulation of GRP78 Enhances Chemotherapy Sensitivity to VP-16 in Lung Adenocarcinoma.]
[Effects of heat shock protein 70-2 gene polymorphisms on the transcription of HSP 70-2 mRNA and the translation of HSP 70 protein in lung cancer].
[Expression and significance of gp96 and immune-related gene CTLA-4, CD8 in lung cancer tissues]
[Relationship between chemosensitivity in vitro and the expression of GRP78 in non-small cell lung cancer.]
[Role of microRNA-155 in Brain Metastasis of Hypoxic Lung Cancer].
[The correlation between the up-regulation of Hsp90 and drug resistance to cisplatin in lung cancer cell line].
[The role of GRP78 on the resistance to cisplatin in SPCA-1 cell line]
Lupus Erythematosus, Discoid
[Studies of heat shock protein 60 and heat shock protein 70 in oral lichen planus]
Lupus Erythematosus, Systemic
Autoantibodies to human heat shock protein (hsp)60 may be induced by Escherichia coli groEL.
Autoantibodies to the heat-shock protein hsp90 in systemic lupus erythematosus.
Autolytic Mycobacterium leprae Hsp65 fragments may act as biological markers for autoimmune diseases.
Bioinformatics-Driven New Immune Target Discovery in Disease.
Detection of antibodies to 65 KD heat shock protein and to human superoxide dismutase in autoimmune hepatitis-molecular mimicry between 65 KD heat shock protein and superoxide dismutase.
Detection of autoantibodies to the 90 kDa heat shock protein in systemic lupus erythematosus and other autoimmune diseases.
Determinant spreading: lessons from animal models and human disease.
Differential heat shock protein overexpression and its clinical relevance in systemic lupus erythematosus.
DNA Vaccination with Heat Shock Protein 70 Protects (NZB x NZW)F1 Mice from Systemic Lupus Erythematosus.
Elevated expression of the Brn-3a and Brn-3b transcription factors in systemic lupus erythematosus correlates with antibodies to Brn-3 and overexpression of Hsp90.
Elevated levels of the 70 kD heat shock protein in patients with systemic lupus erythematosus are not dependent on enhanced transcription of the hsp70 gene.
Elevated levels of the 90 kD heat shock protein in patients with systemic lupus erythematosus are dependent upon enhanced transcription of the hsp90 beta gene.
Elevated levels of the 90 kDa heat shock protein (hsp90) in SLE correlate with levels of IL-6 and autoantibodies to hsp90.
Elevation of IL-6 in transgenic mice results in increased levels of the 90 kDa heat shock protein (hsp90) and the production of anti-hsp90 antibodies.
Enhanced expression of the heat shock protein gene in peripheral blood mononuclear cells of patients with active systemic lupus erythematosus.
Epitopes of microbial and human heat shock protein 60 and their recognition in myalgic encephalomyelitis.
Expression of heat-shock proteins in Streptococcus pyogenes and their immunoreactivity with sera from patients with streptococcal diseases.
Heat shock protein 90 inhibition by 17-DMAG lessens disease in the MRL/lpr mouse model of systemic lupus erythematosus.
Heat shock protein 90: a pathophysiological factor and novel treatment target in autoimmune bullous skin diseases.
Heat-shock protein synthesis by human peripheral mononuclear cells from SLE patients.
Identification of gp96 as a novel target for treatment of autoimmune disease in mice.
Increased levels of antibodies to heat shock proteins with increasing age in Mrl/Mp-lpr/lpr mice.
Interleukin 6 activates heat-shock protein 90 beta gene expression.
Lupus-specific kidney deposits of HSP90 are associated with altered IgG idiotypic interactions of anti-HSP90 autoantibodies.
Polymorphism of the heat-shock protein gene HSP70-2 in systemic lupus erythematosus.
Role of hsp90 in systemic lupus erythematosus and its clinical relevance.
Spontaneous activation of heat shock protein gene transcription in peripheral blood mononuclear cells of individuals with active systemic lupus erythematosus.
Surface expression of heat shock protein 90 by blood mononuclear cells from patients with systemic lupus erythematosus.
The 8.5-kb PstI allele of the stress protein gene, Hsp70-2: an independent risk factor for systemic lupus erythematosus in African Americans?
The expression of molecular chaperone HSP90 and IL-6 in patients with systemic lupus erythematosus.
The HSP90 Inhibitor Ganetespib Alleviates Disease Progression and Augments Intermittent Cyclophosphamide Therapy in the MRL/lpr Mouse Model of Systemic Lupus Erythematosus.
The HSP90 Inhibitor, 17-AAG, Influences the Activation and Proliferation of T Lymphocytes via AKT/GSK3? Signaling in MRL/lpr Mice.
The regulation of heat shock proteins and their role in systemic lupus erythematosus.
The role of hsp90 in SLE.
The tissue specific elevation in synthesis of the 90 kDa heat shock protein precedes the onset of disease in lupus prone MRL/lpr mice.
Transcription of the genes encoding the small heat shock protein ubiquitin is unchanged in patients with systemic lupus erythematosus.
Transposable element dysregulation in systemic lupus erythematosus and regulation by histone conformation and Hsp90.
[The relationship between mRNA level of glucocorticoid receptor ?, heat shock protein 90, protein level of macrophage migration inhibitory factor and glucocorticoid resistance in systemic lupus erythematosus].
Lupus Nephritis
Lupus-specific kidney deposits of HSP90 are associated with altered IgG idiotypic interactions of anti-HSP90 autoantibodies.
Lyme Disease
Characterization of Borrelia burgdorferi proteins reactive with antibodies in synovial fluid of a patient with Lyme arthritis.
Evaluation of genetic divergence among Borrelia burgdorferi isolates by use of OspA, fla, HSP60, and HSP70 gene probes.
groEL expression in gyrB mutants of Borrelia burgdorferi.
H9724, a monoclonal antibody to Borrelia burgdorferi's flagellin, binds to heat shock protein 60 (HSP60) within live neuroblastoma cells: a potential role for HSP60 in peptide hormone signaling and in an autoimmune pathogenesis of the neuropathy of Lyme disease.
Heat shock protein 70 of the agent of human granulocytic ehrlichiosis binds to Borrelia burgdorferi antibodies.
Immune recognition of human Hsp60 by Lyme disease patient sera.
T cell and antibody reactivity with the Borrelia burgdorferi 60-kDa heat shock protein in Lyme arthritis.
Utility of laboratory testing in autoimmune inner ear disease.
Lymphatic Metastasis
Acidic microenvironment plays a key role in human melanoma progression through a sustained exosome mediated transfer of clinically relevant metastatic molecules.
Association of elevated GRP78 expression with increased lymph node metastasis and poor prognosis in patients with gastric cancer.
Can breast cancer Hsp 27 (Heat Shock Protein 27000) expression influence axillary lymph node status?
Concomitant high expression of ER?36, GRP78 and GRP94 is associated with aggressive papillary thyroid cancer behavior.
Construction and selection of subtracted cDNA library of mouse hepatocarcinoma cell lines with different lymphatic metastasis potential.
Decreased GRP78 protein expression is a potential prognostic marker of oral squamous cell carcinoma in Taiwan.
Elevated HSP90 associates with expression of HIF-1? and p-AKT and is predictive of poor prognosis in nasopharyngeal carcinoma.
Estrogen receptor-?36-mediated rapid estrogen signaling regulates 78 kDa glucose-regulated protein expression in gastric carcinoma cells.
Expression of GRP78 predicts taxane-based therapeutic resistance and recurrence of human gastric cancer.
Expression of major heat shock proteins in prostate cancer: correlation with clinicopathological outcomes in patients undergoing radical prostatectomy.
Expressions of GRP78 and Bax associate with differentiation, metastasis, and apoptosis in non-small cell lung cancer.
Glucose-regulated protein GRP78 is up-regulated in prostate cancer and correlates with recurrence and survival.
GRP78 and GAL3, differentially regulated by lymph node homogenates, as potential biomarkers for lymph node metastasis in mouse hepatocellular carcinoma cells.
GRP78 positively regulates estrogen?stimulated cell growth mediated by ER??36 in gastric cancer cells.
Heat shock protein 27 overexpression in breast cancer lymph node metastasis.
Heat shock protein 60 overexpression is associated with the progression and prognosis in gastric cancer.
Heat shock protein 90 as a molecular target for therapy in oral squamous cell carcinoma: Inhibitory effects of 17?DMAG and ganetespib on tumor cells.
High expression of glucose-regulated protein 78 (GRP78) is associated with metastasis and poor prognosis in patients with esophageal squamous cell carcinoma.
High expression of heat shock protein 90 is associated with tumor aggressiveness and poor prognosis in patients with advanced gastric cancer.
High Levels of Hsp90 Cochaperone p23 Promote Tumor Progression and Poor Prognosis in Breast Cancer by Increasing Lymph Node Metastases and Drug Resistance.
Identification of breast cancer metastasis-associated proteins in an isogenic tumor metastasis model using two-dimensional gel electrophoresis and liquid chromatography-ion trap-mass spectrometry.
Immunohistochemical expression of Hsp60 correlates with tumor progression and hormone resistance in prostate cancer.
Is co-expression of USP22 and HSP90 more effective in predicting prognosis of gastric cancer?
MDA-9 and GRP78 as potential diagnostic biomarkers for early detection of melanoma metastasis.
Mortalin expression in pancreatic cancer and its clinical and prognostic significance.
Mortalin overexpression predicts poor prognosis in early stage of non-small cell lung cancer.
Overexpression of GRP78 and GRP94 are markers for aggressive behavior and poor prognosis in gastric carcinomas.
Overexpression of GRP78 and GRP94 is involved in colorectal carcinogenesis.
Preoperative heat shock protein 47 levels identify colorectal cancer patients with lymph node metastasis and poor prognosis.
Proteomics analysis of differential protein expression identifies heat shock protein 47 as a predictive marker for lymph node metastasis in patients with colorectal cancer.
Relationship between the expression of phosphorylated heat shock protein beta-1 with lymph node metastases of breast cancer.
Significance of expression of heat shock protein90alpha in human gastric cancer.
The clinicopathological significance of Mortalin overexpression in invasive ductal carcinoma of breast.
The expression of HSP60 and HSP10 in large bowel carcinomas with lymph node metastase.
[Comparative proteomics of the serum in patients with nasopharyngeal carcinoma: a study with two-dimensional electrophoresis and MALDI-TOF-MS]
[Expression of HSP27 in colorectal carcinoma and its relationship with lymphatic metastasis.]
Lymphocytic Choriomeningitis
Immunization with a lymphocytic choriomeningitis virus peptide mixed with heat shock protein 70 results in protective antiviral immunity and specific cytotoxic T lymphocytes.
Lymphoma
16-Hydroxycleroda-3, 13-dien-15, 16-olide inhibits the proliferation and induces mitochondrial-dependent apoptosis through Akt, mTOR, and MEK-ERK pathways in human renal carcinoma cells.
17-AAG enhances the cytotoxicity of flavopiridol in mantle cell lymphoma via autophagy suppression.
A phase I study of PF-04929113 (SNX-5422), an orally bioavailable heat shock protein 90 inhibitor, in patients with refractory solid tumor malignancies and lymphomas.
A Purine Scaffold HSP90 Inhibitor BIIB021 Has Selective Activity against KSHV-Associated Primary Effusion Lymphoma and Blocks vFLIP K13-Induced NF-?B.
A purine scaffold Hsp90 inhibitor destabilizes BCL-6 and has specific antitumor activity in BCL-6-dependent B cell lymphomas.
Aberrant protein expression in cerebral cortex of fetus with Down syndrome.
Abundance of heat shock proteins (hsp89, hsp60, and hsp27) in malignant cells of Hodgkin's disease.
Activation of MYC, a bona fide client of HSP90, contributes to intrinsic ibrutinib resistance in mantle cell lymphoma.
Amino acid sequence of a chicken heat shock protein derived from the complementary DNA nucleotide sequence.
Analysis of native forms and isoform compositions of the mouse 90-kDa heat shock protein, HSP90.
Anti-cancer activity of withaferin A in B-cell lymphoma.
Antiproliferative and proapoptotic activity of GUT-70 mediated through potent inhibition of Hsp90 in mantle cell lymphoma.
Apoptotic induction and inhibition of NF-?B signaling pathway in human prostatic cancer PC3 cells by natural compound 2,2'-oxybis (4-allyl-1-methoxybenzene), biseugenol B, from Litsea costalis: an in vitro study.
Assessing and comparing antioxidant activities of lactobacilli strains by using different chemical and cellular antioxidant methods.
BIIB021, an Hsp90 inhibitor: A promising therapeutic strategy for blood malignancies (Review).
Calmodulin-regulated binding of the 90-kDa heat shock protein to actin filaments.
CD30 Induces Heat Shock Protein 90 and Signal Integration in Classic Hodgkin Lymphoma Cells.
CHM-1 Suppresses Formation of Cell Surface-associated GRP78-p85? Complexes, Inhibiting PI3K-AKT Signaling and Inducing Apoptosis of Human Nasopharyngeal Carcinoma Cells.
Chronic Akt activation attenuated lipopolysaccharide-induced cardiac dysfunction via Akt/GSK3?-dependent inhibition of apoptosis and ER stress.
Clinical experience with the heat shock protein-90 inhibitor, tanespimycin, in patients with relapsed lymphoma.
Co-treatment with heat shock protein 90 inhibitor 17-dimethylaminoethylamino-17-demethoxygeldanamycin (DMAG) and vorinostat: A highly active combination against human mantle cell lymphoma (MCL) cells.
Consequences of heat shock protein 72 (Hsp72) expression and activity on stress-induced apoptosis in CD30(+) NPM-ALK(+) anaplastic large-cell lymphomas.
Cooperation between Hsp90 and mortalin/GRP75 in resistance to cell death induced by complement C5b-9.
Dopamine impairs functional integrity of rat hepatocytes through nuclear factor kappa B activity modulation: An in vivo, ex vivo, and in vitro study.
Dual Targeting of Protein Degradation Pathways with the Selective HDAC6 Inhibitor ACY-1215 and Bortezomib Is Synergistic in Lymphoma.
Effect of alterations in apoptotic pathway on development of metabolic syndrome in patients with psoriasis vulgaris.
Effect of high cell density on the growth properties of tumor cells: a role in tumor cytotoxicity of chemotherapeutic drugs.
Evidence for intracellular association of the glucocorticoid receptor with the 90-kDa heat shock protein.
Exogenous vascular endothelial growth factor delivery prior to endothelial precursor cell transplantation in orthotopic liver transplantation-induced hepatic ischemia/reperfusion injury.
Expression of a defective mouse mammary tumor virus envelope glycoprotein precursor which binds stably to GRP78 within the lumen of the endoplasmic reticulum is associated with decreased glucocorticoid-induced apoptosis in mouse lymphoma cells.
Expression of heat-shock protein-90 in non-Hodgkin's lymphomas.
Expression of HSP60 in gastric lymphoma treated by a combination of trichosanthin and radiotherapy and its mechanism.
FLT-PET Is Superior to FDG-PET for Very Early Response Prediction in NPM-ALK-Positive Lymphoma Treated with Targeted Therapy.
Ganetespib: research and clinical development.
Heat shock protein 70 (Hsp70)-stimulated deoxycytidine deaminases from a human lymphoma cell but not the activation-induced cytidine deaminase (AID) from Ramos 6.4 human Burkitt's lymphoma cells.
Heat shock protein 70 regulates Tcl1 expression in leukemia and lymphomas.
Heat shock protein 90 inhibitors in non-small-cell lung cancer.
Heat shock protein 90 inhibitors repress latent membrane protein 1 (LMP1) expression and proliferation of Epstein-Barr virus-positive natural killer cell lymphoma.
Heat shock protein 90 relieves heat stress damage of myocardial cells by regulating Akt and PKM2 signaling in vivo.
Heat shock protein 90.
Heat shock protein vaccination and directed IL-2 therapy amplify tumor immunity rapidly following bone marrow transplantation in mice.
Hexavalent chromium-induced apoptosis in Hep3B cells is accompanied by calcium overload, mitochondrial damage, and AIF translocation.
HSP100, a 100-kDa heat shock protein, is a Ca2+-calmodulin-regulated actin-binding protein.
Hsp90 inhibition overcomes HGF-triggering resistance to EGFR-TKIs in EGFR-mutant lung cancer by decreasing client protein expression and angiogenesis.
HSP90 inhibition overcomes ibrutinib resistance in mantle cell lymphoma.
HSP90 Inhibitor 17-AAG Selectively Eradicates Lymphoma Stem Cells.
Hsp90? Mediates BMI1 Expression in Breast Cancer Stem/Progenitor Cells through Facilitating Nuclear Translocation of c-Myc and EZH2.
HSPH1 inhibition downregulates Bcl-6 and c-Myc and hampers the growth of human aggressive B-cell non-Hodgkin lymphoma.
Impact of Heat Shock Protein 90 Inhibition on the Proteomic Profile of Lung Adenocarcinoma as Measured by Two-Dimensional Electrophoresis Coupled with Mass Spectrometry.
Improved Clinical Outcome in Indolent B-Cell Lymphoma Patients Vaccinated with Autologous Tumor Cells Experiencing Immunogenic Death.
Increased Tenascin C, Osteopontin and HSP90 Levels in Plasmatic Small Extracellular Vesicles of Pediatric ALK-Positive Anaplastic Large Cell Lymphoma: New Prognostic Biomarkers?
Induction of endoplasmic reticulum stress in thymic lymphocytes by the envelope precursor polyprotein of a murine leukemia virus during the preleukemic period.
Induction of human hsp60 expression in monocytic cell lines.
Intravenous Immunoglobulin G Suppresses Heat Shock Protein (HSP)-70 Expression and Enhances the Activity of HSP90 and Proteasome Inhibitors.
Involvement of c-Fos in signaling grp78 induction following ER calcium release.
KSHV vFLIP binds to IKK-gamma to activate IKK.
Lee J, Zhang LL, Wu W, et al. Activation of MYC, a bona fide client of HSP90, contributes to intrinsic ibrutinib resistance in mantle cell lymphoma. Blood Adv. 2018;2(16):2039-2051.
Localization of collagen modifying enzymes on fibroblastic reticular cells and follicular dendritic cells in non-neoplastic and neoplastic lymphoid tissues.
Matrix metalloproteinase-9 is upregulated in nucleophosmin-anaplastic lymphoma kinase-positive anaplastic lymphomas and activated at the cell surface by the chaperone heat shock protein 90 to promote cell invasion.
Modulatory effects of mycobacterial heat-shock protein 70 in DNA vaccination against lymphoma.
Nucleophosmin-anaplastic lymphoma kinase (NPM-ALK), a novel Hsp90-client tyrosine kinase: down-regulation of NPM-ALK expression and tyrosine phosphorylation in ALK(+) CD30(+) lymphoma cells by the Hsp90 antagonist 17-allylamino,17-demethoxygeldanamycin.
Oroxin B selectively induces tumor-suppressive ER stress and concurrently inhibits tumor-adaptive ER stress in B-lymphoma cells for effective anti-lymphoma therapy.
P-glycoprotein confers acquired resistance to 17-DMAG in lung cancers with an ALK rearrangement.
Polymorphism in the tumor necrosis factor-alpha promotor region and in the heat shock protein 70 genes associated with malignant tumors.
Preferential synthesis of the 78-Kd glucose-regulated protein in glucocorticoid-treated S49 mouse lymphoma cells.
Proteome-wide changes induced by the Hsp90 inhibitor, geldanamycin in anaplastic large cell lymphoma cells.
Proteomic analysis of exosomes derived from human lymphoma cells.
Purification and characterization of the 90-kDa heat-shock protein from mammalian tissues.
Radiosynthesis of the iodine-124 labeled Hsp90 inhibitor PU-H71.
Regulation of activation-induced deaminase stability and antibody gene diversification by Hsp90.
Relationship between defective mouse mammary tumor virus envelope glycoprotein synthesis and GRP78 synthesis in glucocorticoid-treated mouse lymphoma cells. Evidence for translational control of GRP78 synthesis.
Role of Specific B-Cell Receptor Antigens in Lymphomagenesis.
Schedule-dependent synergy between the heat shock protein 90 inhibitor 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin and doxorubicin restores apoptosis to p53-mutant lymphoma cell lines.
Targeted therapy of BCL6-dependent diffuse large B-cell lymphomas by heat-shock protein 90 inhibition.
The effects of heat shock protein 90 inhibitors on apoptosis and viral replication in primary effusion lymphoma cells.
The heat shock protein 90 inhibitor 17-AAG induces cell cycle arrest and apoptosis in mantle cell lymphoma cell lines by depleting cyclin D1, Akt, Bid and activating caspase 9.
The heat shock protein 90 inhibitor BIIB021 suppresses the growth of T and natural killer cell lymphomas.
The heat shock protein-90 co-chaperone, Cyclophilin 40, promotes ALK-positive, anaplastic large cell lymphoma viability and its expression is regulated by the NPM-ALK oncoprotein.
The heat-shock protein 90 inhibitor, geldanamycin, induces apoptotic cell death in Epstein-Barr virus-positive NK/T-cell lymphoma by Akt down-regulation.
The HSP90 inhibitor 17-AAG synergizes with doxorubicin and U0126 in anaplastic large cell lymphoma irrespective of ALK expression.
The Hsp90 inhibitor IPI-504 overcomes bortezomib resistance in mantle cell lymphoma in vitro and in vivo by down-regulation of the prosurvival ER chaperone BiP/Grp78.
The Hsp90 inhibitor IPI-504 rapidly lowers EML4-ALK levels and induces tumor regression in ALK-driven NSCLC models.
The Hsp90 inhibitor SNX-7081 is synergistic with fludarabine nucleoside via DNA damage and repair mechanisms in human, p53-negative chronic lymphocytic leukemia.
Therapeutic targeting of membrane-associated GRP78 in leukemia and lymphoma: preclinical efficacy in vitro and formal toxicity study of BMTP-78 in rodents and primates.
Thermotolerance in the absence of induced heat shock proteins in a murine lymphoma.
Three-step purification method and characterization of the bovine brain 90-kDa heat shock protein.
Two mammalian heat shock proteins, HSP90 and HSP100, are actin-binding proteins.
Ubiquitination and proteasomal degradation of nucleophosmin-anaplastic lymphoma kinase induced by 17-allylamino-demethoxygeldanamycin: role of the co-chaperone carboxyl heat shock protein 70-interacting protein.
Zinc carnosine works with bovine colostrum in truncating heavy exercise-induced increase in gut permeability in healthy volunteers.
Lymphoma, B-Cell
16-Hydroxycleroda-3, 13-dien-15, 16-olide inhibits the proliferation and induces mitochondrial-dependent apoptosis through Akt, mTOR, and MEK-ERK pathways in human renal carcinoma cells.
A novel strategy for preserving renal grafts in an ex vivo setting: potential for enhancing the marginal donor pool.
A study on the biological function of heat shock factor 1 proteins in breast cancer.
Are Atlantic cod in Store Lungegårdsvann, a seawater recipient in Bergen, affected by environmental contaminants? A qRT-PCR survey.
AUY922 effectively targets against activated B cell subtype of diffuse large B-cell lymphoma and low-grade lymphoma cells harboring genetic alteration-associated nuclear factor-?B activation.
CHM-1 Suppresses Formation of Cell Surface-associated GRP78-p85? Complexes, Inhibiting PI3K-AKT Signaling and Inducing Apoptosis of Human Nasopharyngeal Carcinoma Cells.
Chronic Akt activation attenuated lipopolysaccharide-induced cardiac dysfunction via Akt/GSK3?-dependent inhibition of apoptosis and ER stress.
Co-expression network analysis of Down's syndrome based on microarray data.
Combinatorial targeting of nuclear export and translation of RNA inhibits aggressive B-cell lymphomas.
Cooperation between Hsp90 and mortalin/GRP75 in resistance to cell death induced by complement C5b-9.
Cytokeratin and protein expression patterns in squamous cell carcinoma of the oral cavity provide evidence for two distinct pathogenetic pathways.
Dendritic cells in neointima formation after rat carotid balloon injury: coordinated expression withanti-apoptotic Bcl-2 and HSP47 in arterial repair.
Dietary supplementation with essential amino acids boosts the beneficial effects of rosuvastatin on mouse kidney.
Dopamine impairs functional integrity of rat hepatocytes through nuclear factor kappa B activity modulation: An in vivo, ex vivo, and in vitro study.
Effect of a heat shock protein 90-specific inhibitor on the proliferation and apoptosis induced by VEGF-C in cervical cancer cells.
Effect of dimerized thrombin fragment TP508 on acute myocardial ischemia reperfusion injury in hypercholesterolemic swine.
Effect of Hydrogen Sulfide in a Porcine Model of Myocardial Ischemia-Reperfusion: Comparison of Different Administration Regimens and Characterization of the Cellular Mechanisms of Protection.
Effects of 17-DMAG on diffuse large B-cell lymphoma cell apoptosis.
Effects of microRNA-21 and microRNA-24 inhibitors on neuronal apoptosis in ischemic stroke.
Exogenous vascular endothelial growth factor delivery prior to endothelial precursor cell transplantation in orthotopic liver transplantation-induced hepatic ischemia/reperfusion injury.
Expression of heat-shock protein-90 in non-Hodgkin's lymphomas.
Ganetespib: research and clinical development.
Heat shock protein 90 inhibitors in non-small-cell lung cancer.
Hexavalent chromium-induced apoptosis in Hep3B cells is accompanied by calcium overload, mitochondrial damage, and AIF translocation.
Identification and characterization of BCL6 translocation partner genes in primary gastric high-grade B-cell lymphoma: heat shock protein 89 alpha is a novel fusion partner gene of BCL6.
In vitro long-term culture of isolated ovine preantral follicles: Influence of ethanol on steroid production, oocyte meiotic resumption, and metabolomic profile.
Lithium beyond psychiatric indications: the reincarnation of a new old drug.
Magnetic thermoablation stimuli alter BCL2 and FGF-R1 but not HSP70 expression profiles in BT474 breast tumors.
Mangiferin mitigates di-(2-ethylhexyl) phthalate-induced testicular injury in rats by modulating oxidative stress-mediated signals, inflammatory cascades, apoptotic pathways, and steroidogenesis.
Methane supplementation improves graft function in experimental heart transplantation.
Neuroprotection by hypoxic preconditioning requires sequential activation of vascular endothelial growth factor receptor and Akt.
Neuroprotective effects of selegiline on rat neural stem cells treated with hydrogen peroxide.
Oncogenic HSP90 facilitates metabolic alterations in aggressive B-cell lymphomas.
Overexpression of ER Protein Processing and Apoptosis Regulator Genes in Human Embryonic Kidney 293 Cells Improves Gene Therapy Vectors Production.
Pathogenicity and virulence of Japanese encephalitis virus: Neuroinflammation and neuronal cell damage.
PI3K/Akt signaling pathway and Hsp70 activate in hippocampus of rats with chronic manganese sulfate exposure.
Promising therapies for the treatment of chronic lymphocytic leukemia.
Protective effect of eupatilin against renal ischemia-reperfusion injury in mice.
Protective Effect of Eupatilin Pretreatment Against Hepatic Ischemia-Reperfusion Injury in Mice.
Role of Specific B-Cell Receptor Antigens in Lymphomagenesis.
Rutin hydrate inhibits apoptosis in the brains of cadmium chloride-treated rats via preserving the mitochondrial integrity and inhibiting endoplasmic reticulum stress.
Specific peptides for the therapeutic targeting of oncogenes.
Survivin Signaling in Clinical Oncology: A Multifaceted Dragon.
Targeted therapy of BCL6-dependent diffuse large B-cell lymphomas by heat-shock protein 90 inhibition.
The heat shock protein 90 inhibitor IPI-504 induces apoptosis of AKT-dependent diffuse large B-cell lymphomas.
Thermotolerance in the absence of induced heat shock proteins in a murine lymphoma.
Wilms' tumor 1-associating protein plays an aggressive role in diffuse large B-cell lymphoma and forms a complex with BCL6 via Hsp90.
Zinc carnosine works with bovine colostrum in truncating heavy exercise-induced increase in gut permeability in healthy volunteers.
Lymphoma, B-Cell, Marginal Zone
Antibodies to human gastric epithelial cells and heat shock protein 60 in Helicobacter pylori positive mucosa associated lymphoid tissue lymphoma.
Detection of Helicobacter pylori associated antigen and heat shock protein 60 on follicular dendritic cells in the germinal centres of low grade B cell lymphoma of gastric mucosa associated lymphoid tissue (MALT).
Expression of heat-shock protein-90 in non-Hodgkin's lymphomas.
Helicobacter pylori heat shock protein B (HspB) localizes in vivo in the gastric mucosa and MALT lymphoma.
Immune response in Helicobacter pylori-induced low-grade gastric-mucosa-associated lymphoid tissue (MALT) lymphoma.
Immunoglobulin G1 antibody response to Helicobacter pylori heat shock protein 60 is closely associated with low-grade gastric mucosa-associated lymphoid tissue lymphoma.
Serum antibodies to Helicobacter pylori and its heat-shock protein 60 correlate with the response of gastric mucosa-associated lymphoid tissue lymphoma to eradication of H. pylori.
[Gastric mucosal immunity induced by H. pylori infection]
Lymphoma, Follicular
Expression of heat-shock protein-90 in non-Hodgkin's lymphomas.
Lymphoma, Large B-Cell, Diffuse
Expression of heat-shock protein-90 in non-Hodgkin's lymphomas.
Oncogenic HSP90 facilitates metabolic alterations in aggressive B-cell lymphomas.
Regulation of hsc70 expression in the human histiocytic lymphoma cell line, U937.
Role of Specific B-Cell Receptor Antigens in Lymphomagenesis.
Wilms' tumor 1-associating protein plays an aggressive role in diffuse large B-cell lymphoma and forms a complex with BCL6 via Hsp90.
Lymphoma, Large-Cell, Anaplastic
Abundance of heat shock proteins (hsp89, hsp60, and hsp27) in malignant cells of Hodgkin's disease.
CD30 Induces Heat Shock Protein 90 and Signal Integration in Classic Hodgkin Lymphoma Cells.
Consequences of heat shock protein 72 (Hsp72) expression and activity on stress-induced apoptosis in CD30(+) NPM-ALK(+) anaplastic large-cell lymphomas.
Expression of heat-shock protein-90 in non-Hodgkin's lymphomas.
FLT-PET Is Superior to FDG-PET for Very Early Response Prediction in NPM-ALK-Positive Lymphoma Treated with Targeted Therapy.
Increased Tenascin C, Osteopontin and HSP90 Levels in Plasmatic Small Extracellular Vesicles of Pediatric ALK-Positive Anaplastic Large Cell Lymphoma: New Prognostic Biomarkers?
Proteome-wide changes induced by the Hsp90 inhibitor, geldanamycin in anaplastic large cell lymphoma cells.
The heat shock protein-90 co-chaperone, Cyclophilin 40, promotes ALK-positive, anaplastic large cell lymphoma viability and its expression is regulated by the NPM-ALK oncoprotein.
The HSP90 inhibitor 17-AAG synergizes with doxorubicin and U0126 in anaplastic large cell lymphoma irrespective of ALK expression.
Lymphoma, Mantle-Cell
17-AAG enhances the cytotoxicity of flavopiridol in mantle cell lymphoma via autophagy suppression.
Activation of MYC, a bona fide client of HSP90, contributes to intrinsic ibrutinib resistance in mantle cell lymphoma.
Antiproliferative and proapoptotic activity of GUT-70 mediated through potent inhibition of Hsp90 in mantle cell lymphoma.
Co-treatment with heat shock protein 90 inhibitor 17-dimethylaminoethylamino-17-demethoxygeldanamycin (DMAG) and vorinostat: A highly active combination against human mantle cell lymphoma (MCL) cells.
Expression of heat-shock protein-90 in non-Hodgkin's lymphomas.
HSP90 inhibition overcomes ibrutinib resistance in mantle cell lymphoma.
Intravenous Immunoglobulin G Suppresses Heat Shock Protein (HSP)-70 Expression and Enhances the Activity of HSP90 and Proteasome Inhibitors.
Lee J, Zhang LL, Wu W, et al. Activation of MYC, a bona fide client of HSP90, contributes to intrinsic ibrutinib resistance in mantle cell lymphoma. Blood Adv. 2018;2(16):2039-2051.
Role of Specific B-Cell Receptor Antigens in Lymphomagenesis.
The heat shock protein 90 inhibitor 17-AAG induces cell cycle arrest and apoptosis in mantle cell lymphoma cell lines by depleting cyclin D1, Akt, Bid and activating caspase 9.
The Hsp90 inhibitor IPI-504 overcomes bortezomib resistance in mantle cell lymphoma in vitro and in vivo by down-regulation of the prosurvival ER chaperone BiP/Grp78.
Lymphoma, Non-Hodgkin
AUY922 effectively targets against activated B cell subtype of diffuse large B-cell lymphoma and low-grade lymphoma cells harboring genetic alteration-associated nuclear factor-?B activation.
Experience with HSP90 inhibitor AUY922 in patients with relapsed or refractory non-Hodgkin lymphoma.
Expression of heat-shock protein-90 in non-Hodgkin's lymphomas.
Increasing Levels of Serum Heat Shock Protein 70 Precede the Development of AIDS-Defining Non-Hodgkin Lymphoma Among Carriers of HLA-B8-DR3.
Polymorphism in the tumor necrosis factor-alpha promotor region and in the heat shock protein 70 genes associated with malignant tumors.
Targeted therapy of BCL6-dependent diffuse large B-cell lymphomas by heat-shock protein 90 inhibition.
Lymphoma, Primary Effusion
A Purine Scaffold HSP90 Inhibitor BIIB021 Has Selective Activity against KSHV-Associated Primary Effusion Lymphoma and Blocks vFLIP K13-Induced NF-?B.
KSHV vFLIP binds to IKK-gamma to activate IKK.
The effects of heat shock protein 90 inhibitors on apoptosis and viral replication in primary effusion lymphoma cells.
Lymphoma, T-Cell
Correlation of BAG-3 and heat shock protein 70 with CD30 expression in T-cell lymphomas.
Expression of heat-shock protein-90 in non-Hodgkin's lymphomas.
Thermotolerance in the absence of induced heat shock proteins in a murine lymphoma.
Lymphoma, T-Cell, Cutaneous
Vorinostat interferes with the signaling transduction pathway of T-cell receptor and synergizes with phosphoinositide-3 kinase inhibitors in cutaneous T-cell lymphoma.
Lymphoma, T-Cell, Peripheral
Expression of heat-shock protein-90 in non-Hodgkin's lymphomas.
Lymphopenia
Acute inducible ablation of GRP78 reveals its role in hematopoietic stem cell survival, lymphogenesis and regulation of stress signaling.
Apoptosis does not contribute to the blood lymphocytopenia observed after intensive and downhill treadmill running in humans.
Epidemiology, genetic variants and clinical course of natural infections with Anaplasma phagocytophilum in a dairy cattle herd.
Lymphoproliferative Disorders
Hsp90 inhibition increases SOCS3 transcript and regulates migration and cell death in chronic lymphocytic leukemia.
Lysosomal Storage Diseases
Intermittent enzyme replacement therapy prevents Neu1 deficiency.
Machado-Joseph Disease
HSP27 and cell death in spinocerebellar ataxia type 3.
Identification of the Drosophila ortholog of HSPB8: implication of HSPB8 loss of function in protein folding diseases.
Upregulation of miR-370 and miR-543 is associated with reduced expression of heat shock protein 40 in spinocerebellar ataxia type 3.
Macular Degeneration
?B-Crystallin Regulates Subretinal Fibrosis by Modulation of Epithelial-Mesenchymal Transition.
Cigarette smoke-related hydroquinone induces filamentous actin reorganization and heat shock protein 27 phosphorylation through p38 and extracellular signal-regulated kinase 1/2 in retinal pigment epithelium: implications for age-related macular degeneration.
Detection of heat shock protein 70 in choroidal neovascularisation secondary to age related macular degeneration.
Hsp90 as a Potential Therapeutic Target in Retinal Disease.
Regulated heat shock protein 27 expression in human retinal pigment epithelium.
The Molecular Chaperone GRP78/BiP as a Therapeutic Target for Neurodegenerative Disorders: A Mini Review.
Unravelling the Role of HSP70 as the Unexplored Molecular Target in Age-Related Macular Degeneration.
Macular Edema
Glucose-regulated protein 78 in the aqueous humor in diabetic macular edema patients.
Malaria
Actin-binding proteins of invasive malaria parasites and the regulation of actin polymerization by a complex of 32/34-kDa proteins associated with heat shock protein 70kDa.
Antibodies specific for heat shock proteins in human and murine malaria.
Biochemical characterization of the apicoplast-targeted AAA+ ATPase ClpB from Plasmodium falciparum.
Cellular and antibody responses to the Plasmodium falciparum heat shock protein Pf72/HSP70 during and after acute malaria in individuals from an endemic area of Brazil.
Chaperone expression profiles correlate with distinct physiological states of Plasmodium falciparum in malaria patients.
Characterization of Plasmodium vivax heat shock protein 70 and evaluation of its value for serodiagnosis of tertian malaria.
Co-chaperones of Hsp90 in Plasmodium falciparum and their concerted roles in cellular regulation.
Comparative structure-function features of Hsp70s of Plasmodium falciparum and human origins.
Demonstration of heat-shock protein 70 in the sporozoite stage of malaria parasites.
Detection of malaria infection via latex agglutination assay.
Heat shock protein 90 as a drug target against protozoan infections: Biochemical characterization of Hsp90 from Plasmodium falciparum, Trypanosoma evansi and evaluation of its inhibitor as a candidate drug.
Heat shock protein 90 from neglected protozoan parasites.
Hsp70s and J Proteins of Plasmodium Parasites Infecting Rodents and Primates: Structure, Function, Clinical Relevance, and Drug Targets.
Human response to a malaria vaccine candidate antigen.
Humoral and cellular immune responses to glucose regulated protein 78 -- a novel Leishmania donovani antigen.
Humoral immune response to the 72 kDa heat shock protein from Plasmodium falciparum in populations at hypoendemic areas of malaria in western Brazilian Amazon.
Identification and characterization of the antiplasmodial activity of Hsp90 inhibitors.
Immunization with the malaria heat shock like protein hsp70-1 enhances transmission to the mosquito.
Metalloprotease activity in a small heat shock protein of the human malaria parasite Plasmodium vivax.
Model System Identifies Kinetic Driver of Hsp90 Inhibitor Activity against African Trypanosomes and Plasmodium falciparum.
Molecular analysis of Plasmodium falciparum co-chaperone Aha1 supports its interaction with and regulation of Hsp90 in the malaria parasite.
Molecular characterization of the heat shock protein 90 gene of the human malaria parasite Plasmodium falciparum.
Molecular cloning and antigenic mapping of heat-shock protein 70 from the malaria species Plasmodium bergheI.
Mouse studies on inhibitors of Plasmodium falciparum Hsp90: progress and challenges.
Overproduction, purification, and characterization of the Plasmodium falciparum heat shock protein 70.
Partners in Mischief: Functional Networks of Heat Shock Proteins of Plasmodium falciparum and Their Influence on Parasite Virulence.
Placental Malaria: A New Insight into the Pathophysiology.
Plasmodial heat shock proteins: targets for chemotherapy.
Plasmodial HSP70s are functionally adapted to the malaria parasite life cycle.
Plasmodium falciparum heat shock protein 70 is able to suppress the thermosensitivity of an Escherichia coli DnaK mutant strain.
Plasmodium falciparum Hop: detailed analysis on complex formation with Hsp70 and Hsp90.
Plasmodium falciparum Hsp70-z, an Hsp110 homologue, exhibits independent chaperone activity and interacts with Hsp70-1 in a nucleotide-dependent fashion.
Plasmodium falciparum R2TP complex: driver of parasite Hsp90 function.
Plasmodium falciparum signal peptide peptidase cleaves malaria heat shock protein 101 (HSP101). Implications for gametocytogenesis.
Post-transcriptional repair of a split heat shock protein 90 gene by mRNA trans-splicing.
Precise limitation of concerted evolution to ORFs in mosquito Hsp82 genes.
Protein Prenylation and Hsp40 in Thermotolerance of Plasmodium falciparum Malaria Parasites.
PTEX component HSP101 mediates export of diverse malaria effectors into host erythrocytes.
Repurposing drugs to target the malaria parasite unfolding protein response.
Selective modulation of plasmodial Hsp70s by small molecules with antimalarial activity.
Solution structure of Plasmodium falciparum Hsp90 indicates a high flexible dimer.
Stage-specific expression of heat shock protein 90 in murine malaria parasite Plasmodium yoelii.
Strong renal expression of heat shock protein 70, high mobility group box 1, inducible nitric oxide synthase, and nitrotyrosine in mice model of severe malaria.
Structural and biochemical characterization of Plasmodium falciparum Hsp70-x reveals functional versatility of its C-terminal EEVN motif.
Structural insights into the binding mechanism of Plasmodium falciparum exported Hsp40-Hsp70 chaperone pair.
Structure of the ATP-binding domain of Plasmodium falciparum Hsp90.
Targeting Heat Shock Protein 90 for Malaria.
The endoplasmic reticulum chaperone PfGRP170 is essential for asexual development and is linked to stress response in malaria parasites.
The heat shock protein 40 family of the malaria parasite Plasmodium falciparum.
The heat shock protein 90 of Plasmodium falciparum and antimalarial activity of its inhibitor, geldanamycin.
The malaria PTEX component PTEX88 interacts most closely with HSP101 at the host-parasite interface.
Three-dimensional structure of heat shock protein 90 from Plasmodium falciparum: molecular modelling approach to rational drug design against malaria.
Uncoupling the Threading and Unfoldase Actions of Plasmodium HSP101 Reveals Differences in Export between Soluble and Insoluble Proteins.
Malaria, Falciparum
Protein Prenylation and Hsp40 in Thermotolerance of Plasmodium falciparum Malaria Parasites.
Malnutrition
Heat shock proteins in porcine ovary: synthesis, accumulation and regulation by stress and hormones.
Malocclusion
MTORC1 coordinates the autophagy and apoptosis signaling in articular chondrocytes in osteoarthritic temporomandibular joint.
Marek Disease
Heat-shock protein 70 is associated with the entry of Marek's disease virus into fibroblast.
Interaction of Marek's disease virus oncoprotein Meq with heat-shock protein 70 in lymphoid tumour cells.
Mastitis
Differentiation of non-aureus staphylococci species isolated from bovine mastitis by PCR-RFLP of groEL and gap genes in comparison to MALDI-TOF mass spectrometry.
Feeding a Saccharomyces cerevisiae fermentation product improves udder health and immune response to a Streptococcus uberis mastitis challenge in mid-lactation dairy cows.
Identification of coagulase-negative staphylococci from bovine mastitis using RFLP-PCR of the groEL gene.
Mutations in HSP70-2 gene change the susceptibility to clinical mastitis in Chinese Holstein.
Use of primers based on the heat shock protein genes hsp70, hsp40, and hsp10, for the detection of bovine mastitis pathogens Streptococcus agalactiae, Streptococcus uberis and Streptococcus bovis.
[Genetic polymorphism of HSP70-1 gene and its correlation with resistance to mastitis in Chinese Holstein]
Mastocytoma
Tumor cell membrane-bound heat shock protein 70 elicits antitumor immunity.
Measles
A single codon in the nucleocapsid protein C terminus contributes to in vitro and in vivo fitness of edmonston measles virus.
Autophagy induction by the pathogen receptor NECTIN4 and sustained autophagy contribute to peste des petits ruminants virus infectivity.
Cancer and Virus Leads by HTS, Chemical Design and SEA Data Mining.
Constitutive overexpression of the major inducible 70 kDa heat shock protein mediates large plaque formation by measles virus.
Heat Shock Protein 90 Ensures Efficient Mumps Virus Replication by Assisting with Viral Polymerase Complex Formation.
Heat shock protein inhibitors increase the efficacy of measles virotherapy.
High affinity binding between Hsp70 and the C-terminal domain of the measles virus nucleoprotein requires an Hsp40 co-chaperone.
hsp70 and a novel axis of type I interferon-dependent antiviral immunity in the measles virus-infected brain.
hsp70-Dependent Antiviral Immunity against Cytopathic Neuronal Infection by Vesicular Stomatitis Virus.
Hsp72 recognizes a P binding motif in the measles virus N protein C-terminus.
HSP90 Chaperoning in Addition to Phosphoprotein Required for Folding but Not for Supporting Enzymatic Activities of Measles and Nipah Virus L Polymerases.
Live Attenuated Measles Virus Vaccine Expressing Helicobacter pylori Heat Shock Protein A.
Modulation of Measles Virus NTAIL Interactions through Fuzziness and Sequence Features of Disordered Binding Sites.
Molecular mimicry between varicella, measles virus and Hsp60 in type 1 diabetes associated HLA-DR3/DR4 molecules.
Medulloblastoma
Expression of heat shock proteins in medulloblastoma.
Immunoexpression patterns for Hypoxia-inducible Factor-1? and von Hippel-Lindau protein, in relation to Hsp90, of human brain tumors.
Inhibition of Hsp90 via 17-DMAG induces apoptosis in a p53-dependent manner to prevent medulloblastoma.
Integrated proteomic platforms for the comparative characterization of medulloblastoma and pilocytic astrocytoma pediatric brain tumors: a preliminary study.
Megalencephaly
MR imaging and 1H-MR spectroscopy in a case of juvenile Alexander disease.
Melanoma
17-(Allylamino)-17-demethoxygeldanamycin activity in human melanoma models.
17-AAG and 17-DMAG-induced inhibition of cell proliferation through B-Raf downregulation in WT B-Raf-expressing uveal melanoma cell lines.
17-AAG inhibits vemurafenib-associated MAP kinase activation and is synergistic with cellular immunotherapy in a murine melanoma model.
17-Aminogeldanamycin Inhibits Constitutive Nuclear Factor-Kappa B (NF-?B) Activity in Patient-Derived Melanoma Cell Lines.
17-Aminogeldanamycin selectively diminishes IRE1?-XBP1s pathway activity and cooperatively induces apoptosis with MEK1/2 and BRAFV600E inhibitors in melanoma cells of different genetic subtypes.
1?,25(OH)(2) D(3) enhances NK susceptibility of human melanoma cells through the enhancement of Hsp60-mediated FAS expression.
2-Methoxyestradiol and Its Combination with a Natural Compound, Ferulic Acid, Induces Melanoma Cell Death via Downregulation of Hsp60 and Hsp90.
2-phenylethynesulphonamide (PFT-?) enhances the anticancer effect of the novel hsp90 inhibitor NVP-AUY922 in melanoma, by reducing GSH levels.
A Mortalin/HSPA9-Mediated Switch in Tumor-Suppressive Signaling of Raf/MEK/Extracellular Signal-Regulated Kinase.
A murine monoclonal antibody directed against the carboxyl-terminal domain of GRP78 suppresses melanoma growth in mice.
A novel C-terminal HSP90 inhibitor KU135 induces apoptosis and cell cycle arrest in melanoma cells.
A novel C-terminal Hsp90 inhibitor KU758 synergizes efficacy in combination with BRAF or MEK inhibitors and targets drug-resistant pathways in BRAF-mutant melanomas.
A novel class of specific Hsp90 small molecule inhibitors demonstrate in vitro and in vivo anti-tumor activity in human melanoma cells.
A novel DNA vaccine constructed by heat shock protein 70 and melanoma antigen-encoding gene 3 against tumorigenesis.
A Phase II trial of 17-allylamino, 17-demethoxygeldanamycin (17-AAG, tanespimycin) in patients with metastatic melanoma.
A phase II trial of vaccination with autologous, tumor-derived heat-shock protein peptide complexes Gp96, in combination with GM-CSF and interferon-alpha in metastatic melanoma patients.
A small molecule cell-impermeant Hsp90 antagonist inhibits tumor cell motility and invasion.
Aberrant DNA methylation silences the novel heat shock protein H11 in melanoma but not benign melanocytic lesions.
Activity of the heat shock protein 90 inhibitor ganetespib in melanoma.
Acute extracellular acidification increases nuclear associated protein levels in human melanoma cells during 42 degrees C hyperthermia and enhances cell killing.
Administration of heat shock protein 65 inhibits murine melanoma growth in vivo.
An investigation into the potential use of serum Hsp70 as a novel tumour biomarker for Hsp90 inhibitors.
Analysis of candidate genes through a proteomics-based approach in primary cell lines from malignant melanomas and their metastases.
Antitumor agent 25-epi Ritterostatin GN1N induces endoplasmic reticulum stress and autophagy mediated cell death in melanoma cells.
Antitumor effects of combined therapy of recombinant heat shock protein 70 and hyperthermia using magnetic nanoparticles in an experimental subcutaneous murine melanoma.
Autoantibodies against cell surface GRP78 promote tumor growth in a murine model of melanoma.
Bcl-2 regulates HIF-1alpha protein stabilization in hypoxic melanoma cells via the molecular chaperone HSP90.
BRAF and NRAS mutations in melanoma: potential relationships to clinical response to HSP90 inhibitors.
Cell-type variation in stress responses as a consequence of manipulating GRP78 expression in neuroectodermal cells.
Cellular stress stimulates nuclear localization signal (NLS) independent nuclear transport of MRJ.
Changes in oligosaccharide chains of autoantibodies to GRP78 expressed during progression of malignant melanoma stimulate melanoma cell growth and survival.
Clinical Significance of Circulating Serum Cellular Heat Shock Protein 90 (HSP90) Level in Patients with Cutaneous Malignant Melanoma
Columbamine suppresses proliferation and invasion of melanoma cell A375 via HSP90-mediated STAT3 activation.
Combination of ionising radiation with hyperthermia increases the immunogenic potential of B16-F10 melanoma cells in vitro and in vivo.
Combined BRAF and HSP90 Inhibition in Patients with Unresectable BRAFV600E-Mutant Melanoma.
Combined effects of the proteasome inhibitor bortezomib and Hsp70 inhibitors on the B16F10 melanoma cell line.
Combined inhibition of Hsp90 and heme oxygenase-1 induces apoptosis and endoplasmic reticulum stress in melanoma.
Comparison of 17-dimethylaminoethylamino-17-demethoxy-geldanamycin (17DMAG) and 17-allylamino-17-demethoxygeldanamycin (17AAG) in vitro: effects on Hsp90 and client proteins in melanoma models.
Constitutive expression of the heat shock protein 72 kDa in human melanoma cells.
Dangerous liaisons: flirtations between oncogenic BRAF and GRP78 in drug-resistant melanomas.
Design, synthesis and molecular mechanisms of novel dual inhibitors of heat shock protein 90/phosphoinositide 3-kinase alpha (Hsp90/PI3K?) against cutaneous melanoma.
Detecting human melanoma cell re-differentiation following BRAF or heat shock protein 90 inhibition using photoacoustic and magnetic resonance imaging.
Development of a Bifunctional Andrographolide-Based Chemical Probe for Pharmacological Study.
Diagnostic and prognostic value of heat shock protein 90? in malignant melanoma.
Differential capacity of chaperone-rich lysates in cross-presenting human endogenous and exogenous melanoma differentiation antigens.
Differential effect of acute and permanent heat shock protein 70 overexpression in tumor cells on lysability by cytotoxic T lymphocytes.
Differential expression of heat shock protein 105 in melanoma and melanocytic naevi.
Discovery of N-pyridoyl-?2 -pyrazolines as Hsp90 inhibitors.
DNAJB6 governs a novel regulatory loop determining Wnt/?-catenin signalling activity.
Dominant negative Rac1 attenuates paclitaxel-induced apoptosis in human melanoma cells through upregulation of heat shock protein 27: a functional proteomic analysis.
Early development of PAT-SM6 for the treatment of melanoma.
Effect of antiangiogenic therapy on luciferase activity in a cytomegalovirus- or HSP70-promoter-transfected M21 tumor model.
Elevated circulatory levels of leptin and resistin impair therapeutic efficacy of dacarbazine in melanoma under obese state.
Emphasizing on heat shock protein 90's utility in head and neck squamous cell carcinoma treatment.
Enhanced susceptibility to cytotoxic T lymphocytes without increase of MHC class I antigen expression after conditional overexpression of heat shock protein 70 in target cells.
Enhanced T-cell activation by immature dendritic cells loaded with HSP70-expressing heat-killed melanoma cells.
Enhancing the treatment effect on melanoma by heat shock protein 70-peptide complexes purified from human melanoma cell lines.
ER Translocation of the MAPK Pathway Drives Therapy Resistance in BRAF-Mutant Melanoma.
Erythroid Differentiation Regulator 1, an Interleukin 18-Regulated Gene, Acts as a Metastasis Suppressor in Melanoma.
Evaluating melanoma drug response and therapeutic escape with quantitative proteomics.
Evaluation of [11C]NMS-E973 as a PET tracer for in vivo visualisation of HSP90.
Expression of chemoresistance-related genes and heat shock protein 72 in hyperthermic isolated limb perfusion of malignant melanoma: an experimental study.
Expression of focal adhesion kinase in uveal melanoma and the effects of Hsp90 inhibition by 17-AAG.
Expression of glucose-regulated stress protein GRP78 is related to progression of melanoma.
Expression of heat shock protein 105 and 70 in malignant melanoma and benign melanocytic nevi.
Expression of Heat Shock Protein 27 in Melanoma Metastases Is Associated with Overall Response to Bevacizumab Monotherapy: Analyses of Predictive Markers in a Clinical Phase II Study.
Expression of HSP90 in gastrointestinal stromal tumours and mesenchymal tumours.
Expression of the CD117, COX-2 and HSP90 antigens and cell proliferation in fine-needle-aspirated cells from metastatic melanomas.
Expression of the heat shock cognate protein HSP73 correlates with tumour thickness of primary melanomas and is enhanced in melanoma metastases.
Extracellular heat shock protein 90: a role for a molecular chaperone in cell motility and cancer metastasis.
Extracellular targeting of endoplasmic reticulum chaperone glucose-regulated protein 170 enhances tumor immunity to a poorly immunogenic melanoma.
Fused imidazoles as potential chemical scaffolds for inhibition of heat shock protein 70 and induction of apoptosis. Synthesis and biological evaluation of phenanthro[9,10-d]imidazoles and imidazo[4,5-f][1,10]phenanthrolines.
Geldanamycin and its anti-cancer activities.
Glucose-regulated protein 78 antagonizes cisplatin and adriamycin in human melanoma cells.
Green fluorescent protein as a marker for monitoring activity of stress-inducible hsp70 rat gene promoter.
Heat shock cognate protein 71-associated peptides function as an epitope for Toxoplasma gondii-specific CD4+ CTL.
Heat shock protein 70 membrane expression and melanoma-associated marker phenotype in primary and metastatic melanoma.
Heat shock protein 70 neutralization exerts potent antitumor effects in animal models of colon cancer and melanoma.
Heat shock protein 90 inhibitor enhances apoptosis by inhibiting the AKT pathway in thermal-stimulated SK-MEL-2 human melanoma cell line.
Heat shock protein expression in the eye and in uveal melanoma.
Heat shock protein peptide complex 96-based vaccines in melanoma: How far we are, how far we can get.
Heat shock protein-90 inhibitors enhance antigen expression on melanomas and increase T cell recognition of tumor cells.
Heat-induced modulation of lamin B content in two different cell lines.
Heat-shock protein 90 inhibitors synergistically enhance melanoma differentiation-associated gene-7-mediated cell killing of human pancreatic carcinoma.
Heterogeneous patterns of constitutive and heat shock induced expression of HLA-linked HSP70-1 and HSP70-2 heat shock genes in human melanoma cell lines.
HSP-27 protein expression in uveal melanoma: correlation with predicted survival.
HSP27 Expression as a Novel Predictive Biomarker for Bevacizumab: is it Cost Effective?
HSP90 as a marker of progression in melanoma.
Hsp90 as a Potential Therapeutic Target in Retinal Disease.
HSP90 inhibition enhances cancer immunotherapy by upregulating interferon response genes.
Hyperthermia enhances CTL cross-priming.
Identification of a 66 kD heat shock protein (HSP) induced in M-14 human melanoma cells by severe hyperthermic treatment.
Identification of a new subset of myeloid suppressor cells in peripheral blood of melanoma patients with modulation by a granulocyte-macrophage colony-stimulation factor-based antitumor vaccine.
Imaging of Firefly Luciferase Activity under Antiangiogenic Therapy in a Heat Shock Protein 70-Transfected Melanoma Tumor Model.
Immune expression and inhibition of heat shock protein 90 in uveal melanoma.
Immunohistochemical expression of C-myc oncogene, heat shock protein 70 and HLA-DR molecules in malignant cutaneous melanoma.
In Vitro and In Vivo Studies of the Biological Effects of Bioceramic (a Material of Emitting High Performance Far-Infrared Ray) Irradiation.
Induction of heat shock protein 70 genes in human lymphocytes during fever therapy.
Induction of Hsp90 protein expression in malignant melanomas and melanoma metastases.
Induction of the 72-kD heat shock protein in human skin melanoma and squamous cell carcinoma cell lines.
Inhibiting HSP90 prevents the induction of myeloid-derived suppressor cells by melanoma cells.
Inhibition of Cancer Cell Growth by GRP78 siRNA Lipoplex via Activation of Unfolded Protein Response.
Inhibition of endoplasmic reticulum stress-induced autophagy sensitizes melanoma cells to temozolomide treatment.
Inhibition of heat shock protein 90 sensitizes melanoma cells to thermosensitive ferromagnetic particle-mediated hyperthermia with low Curie temperature.
Inhibition of Hsp90 and 70 sensitizes melanoma cells to hyperthermia using ferromagnetic particles with a low Curie temperature.
Inhibition of HSP90 by AT13387 delays the emergence of resistance to BRAF inhibitors and overcomes resistance to dual BRAF and MEK inhibition in melanoma models.
Inhibition of mouse RM-1 prostate cancer and B16F10 melanoma by the fusion protein of HSP65 & STEAP1 186-193.
Inhibition of telomerase activity by geldanamycin and 17-allylamino, 17-demethoxygeldanamycin in human melanoma cells.
Inhibition of Wee1, AKT and CDK4 underlies the efficacy of the HSP90 inhibitor XL888 in an in vivo model of NRAS mutant melanoma.
Inhibitors of HSP90 in melanoma.
Intracellular acidification abrogates the heat shock response and compromises survival of human melanoma cells.
Introduction of 65 kDa antigen of Mycobacterium tuberculosis to cancer cells enhances anti-tumor effect of BCG therapy.
Involvement of ER stress and activation of apoptotic pathways in fisetin induced cytotoxicity in human melanoma.
iTRAQ Quantitative Proteomic Comparison of Metastatic and Non-Metastatic Uveal Melanoma Tumors.
Killing of normal melanocytes, combined with heat shock protein 70 and CD40L expression, cures large established melanomas.
Ligation of cancer cell surface GRP78 with antibodies directed against its COOH-terminal domain up-regulates p53 activity and promotes apoptosis.
Ligation of cell surface GRP78 with antibody directed against the COOH-terminal domain of GRP78 suppresses Ras/MAPK and PI 3-kinase/AKT signaling while promoting caspase activation in human prostate cancer cells.
mda-7 (IL-24) Mediates selective apoptosis in human melanoma cells by inducing the coordinated overexpression of the GADD family of genes by means of p38 MAPK.
MDA-9 and GRP78 as potential diagnostic biomarkers for early detection of melanoma metastasis.
Medical Gas Plasma Jet Technology Targets Murine Melanoma in an Immunogenic Fashion.
Melanoma and lymphocyte cell-specific targeting incorporated into a heat shock protein cage architecture.
Melanoma and the Unfolded Protein Response.
Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET.
Modulation of Diacylglycerol-Induced Melanogenesis in Human Melanoma and Primary Melanocytes: Role of Stress Chaperone Mortalin.
Modulation of heat shock protein synthesis in two human melanoma cell lines.
Modulation of melanoma cell phospholipid metabolism in response to heat shock protein 90 inhibition.
Modulation of Plasma Membrane Composition and Microdomain Organization Impairs Heat Shock Protein Expression in B16-F10 Mouse Melanoma Cells.
Molecular oncogene markers and their significance in cutaneous malignant melanoma.
Monoclonal antibody 4C5 immunostains human melanomas and inhibits melanoma cell invasion and metastasis.
Mortalin depletion induces MEK/ERK-dependent and ANT/CypD-mediated death in vemurafenib-resistant B-RafV600E melanoma cells.
NAD(P)H:Quinone Oxidoreductase-1 Expression Sensitizes Malignant Melanoma Cells to the HSP90 Inhibitor 17-AAG.
Novel Functions of CD147 in the Mitochondria Exacerbates Melanoma Metastasis.
Overcoming acquired BRAF inhibitor resistance in melanoma via targeted inhibition of Hsp90 with ganetespib.
Overexpression of Hsp25 in K1735 murine melanoma cells enhances susceptibility to natural killer cytotoxicity.
Overexpression of Hsp27 affects the metastatic phenotype of human melanoma cells in vitro.
Patterns of GRP78 and MTJ1 expression in primary cutaneous malignant melanoma.
Phase II trial of 17-allylamino-17-demethoxygeldanamycin in patients with metastatic melanoma.
Phase III comparison of vitespen, an autologous tumor-derived heat shock protein gp96 peptide complex vaccine, with physician's choice of treatment for stage IV melanoma: the C-100-21 Study Group.
Phenotype-based variation as a biomarker of sensitivity to molecularly targeted therapy in melanoma.
Phenotypic identification of the redox dye methylene blue as an antagonist of heat shock response gene expression in metastatic melanoma cells.
Platelet count correlates with stage and predicts survival in melanoma.
Potential diagnostic significance of HSP90, ACS/TMS1, and L-plastin in the identification of melanoma.
Prognostic implications of markers of the metabolic phenotype in human cutaneous melanoma.
Prophylactic Admission of an In Vitro Reconstructed Complexes of Human Recombinant Heat Shock Proteins and Melanoma Antigenic Peptides Activates Anti-Melanoma Responses in Mice.
Proteomic investigation of anti-tumor activities exerted by sinularin against A2058 melanoma cells.
Proteomic investigation of the sinulariolide-treated melanoma cells A375: effects on the cell apoptosis through mitochondrial-related pathway and activation of caspase cascade.
Recent Patents on Heat Shock Proteins Targeting Antibodies.
Regulation of stability of cyclin-dependent kinase CDK11p110 and a caspase-processed form, CDK11p46, by Hsp90.
Restored expression of the atypical heat shock protein H11/HspB8 inhibits the growth of genetically diverse melanoma tumors through activation of novel TAK1-dependent death pathways.
Results from phase II trial of HSP90 inhibitor, STA-9090 (ganetespib), in metastatic uveal melanoma.
Retraction notice to "A novel class of specific Hsp90 small molecule inhibitors demonstrate in vitro and in vivo anti-tumor activity in human melanoma cells".
SNX-2112, an Hsp90 inhibitor, induces apoptosis and autophagy via degradation of Hsp90 client proteins in human melanoma A-375 cells.
Steady-State Levels of Phosphorylated Mitogen-Activated Protein Kinase Kinase 1/2 Determined by Mortalin/HSPA9 and Protein Phosphatase 1 Alpha in KRAS and BRAF Tumor Cells.
Suppression of murine melanoma growth by a vaccine of attenuated Salmonella carrying heat shock protein 70 and Herpes simplex virus-thymidine kinase genes.
Synergistic anti-tumor effect of 17AAG with the PI3K/mTOR inhibitor NVP-BEZ235 on human melanoma.
Targeting CDK2 overcomes melanoma resistance against BRAF and Hsp90 inhibitors.
Targeting ER stress-induced autophagy overcomes BRAF inhibitor resistance in melanoma.
Targeting GRP78 to enhance melanoma cell death.
The Broad Stroke of Hsp90 Inhibitors: Painting over the RAF Inhibitor Paradox.
The common heat shock protein receptor CD91 is up-regulated on monocytes of advanced melanoma slow progressors.
The Escherichia coli Subtilase Cytotoxin A Subunit Specifically Cleaves Cell-Surface GRP78 and Abolishes COOH-Terminal-Dependent Signaling.
The heat shock protein-90 inhibitor XL888 overcomes BRAF inhibitor resistance mediated through diverse mechanisms.
The Ig VH complementarity-determining region 3-containing Rb9 peptide, inhibits melanoma cells migration and invasion by interactions with Hsp90 and an adhesion G-protein coupled receptor.
The Potential of Targeting P53 and HSP90 Overcoming Acquired MAPKi-Resistant Melanoma.
Time-of-day specificity of anticancer drugs may be mediated by circadian regulation of the cell cycle.
TRAIL-induced apoptosis of human melanoma cells involves activation of caspase-4.
Tumor antigen delivered by Salmonella III secretion protein fused with heat shock protein 70 induces protection and eradication against murine melanoma.
Unbiased High-Throughput Drug Combination Pilot Screening Identifies Synergistic Drug Combinations Effective against Patient-Derived and Drug-Resistant Melanoma Cell Lines.
V600E B-Raf requires the Hsp90 chaperone for stability and is degraded in response to Hsp90 inhibitors.
Vaccination of metastatic melanoma patients with autologous tumor-derived heat shock protein gp96-peptide complexes: clinical and immunologic findings.
[Biodistribution of the recombinant heat shock protein rhHsp70 in intracranial C6 glioma models in Wistar rats and subcutaneos B16/F10 melanoma in C57BL/6 mice].
[Butein promotes the role of mH2A in MAPK signaling pathway through targeting GRP78 in regulating biological behaviors of melanoma].
[Intratumor injection of recombinant attenuated salmonella carrying Mycobacterium tuberculosis heat shock protein 70 and herpes simplex virus thymidine kinase genes to suppress murine melanoma growth].
Melanoma, Experimental
Fusion protein of ATPase domain of Hsc70 with TRP2 acting as a tumor vaccine against B16 melanoma.
Heat shock protein levels are not elevated in heat-resistant B16 melanoma cells.
The heat shock protein 90 inhibitor SNX-2112 inhibits B16 melanoma cell growth in vitro and in vivo.
MELAS Syndrome
Activation of the mitochondrial protein quality control system and actin cytoskeletal alterations in cells harbouring the MELAS mitochondrial DNA mutation.
Melioidosis
groEL encodes a highly antigenic protein in Burkholderia pseudomallei.
Production and evaluation of recombinant Burkholderia pseudomallei GroEL and OmpA proteins for serodiagnosis of melioidosis.
Seronegative bacteremic melioidosis caused by Burkholderia pseudomallei with ambiguous biochemical profile: clinical importance of accurate identification by 16S rRNA gene and groEL gene sequencing.
Memory Disorders
A CNS-permeable Hsp90 inhibitor rescues synaptic dysfunction and memory loss in APP-overexpressing Alzheimer's mouse model via an HSF1-mediated mechanism.
Heat Shock Cognate 70 Inhibitor, VER-155008, Reduces Memory Deficits and Axonal Degeneration in a Mouse Model of Alzheimer's Disease.
Luteolin alleviates cognitive impairment in Alzheimer's disease mouse model via inhibiting endoplasmic reticulum stress-dependent neuroinflammation.
Meniere Disease
Failure of elevated heat shock protein 70 antibodies to alter cochlear function in mice.
HSP70 antibodies in 80 patients with "clinically certain" Meniere's disease.
Polymorphic analysis of the heat-shock protein 70 gene (HSPA1A) in Ménière's disease.
Polymorphic analysis of the heat-shock protein 70 gene (HSPA1A) in Meniere's disease.
Prevalence of heat shock protein in patients with Meniere's disease and allergy.
Recognition of a dominant epitope in bovine heat-shock protein 70 in inner ear disease.
Viral infection and serum antibodies to heat shock protein 70 in the acute phase of Ménière's disease.
Meningeal Neoplasms
Different immunohistochemical levels of Hsp60 and Hsp70 in a subset of brain tumors and putative role of Hsp60 in neuroepithelial tumorigenesis.
Meningioma
Elevated levels of mortalin expression in human brain tumors.
Expression of heat shock proteins in brain tumors.
Human meningiomas: immunohistochemical localization of progesterone receptor and heat shock protein 27 and absence of estrogen receptor and PS2.
Wild type and alternatively spliced estrogen receptor messenger RNA in human meningioma tissue and MCF7 breast cancer cells.
[Changes in the cytokine profile in patients with supratentorial meningiomas].
Meningitis
A pilot study to detect high mobility group box 1 and heat shock protein 72 in cerebrospinal fluid of pediatric patients with meningitis.
Hypothermia decreases excitatory neurotransmitter release in bacterial meningitis in rabbits.
Superior adjuvanticity of the genetically fused D1 domain of Neisseria meningitides Ag473 lipoprotein among three Toll-like receptor ligands.
Meningitis, Bacterial
Cerebrospinal fluid levels of extracellular heat shock protein 72: A potential biomarker for bacterial meningitis in children.
Meningitis, Pneumococcal
Anti-inflammatory and Oto-Protective Effect of the Small Heat Shock Protein Alpha B-Crystallin (HspB5) in Experimental Pneumococcal Meningitis.
Experimental pneumococcal meningitis causes central nervous system pathology without inducing the 72-kd heat shock protein.
Meningococcal Infections
Glutamine depletion and heat shock protein 70 (HSP70) in children with meningococcal disease.
Immunogenicity of the meningococcal stress protein MSP63 during natural infection.
Meningoencephalitis
The unfolded protein response (UPR) pathway in Cryptococcus.
Menkes Kinky Hair Syndrome
Cerebellar expression of copper chaperone for superoxide, cytosolic cu/zn-superoxide dismutase, 4-hydroxy-2-nonenal, acrolein and heat shock protein 32 in patients with menkes kinky hair disease: immunohistochemical study.
MERRF Syndrome
Decreased heat shock protein 27 expression and altered autophagy in human cells harboring A8344G mitochondrial DNA mutation.
The protective roles of phosphorylated heat shock protein?27 in human cells harboring myoclonus epilepsy with ragged-red fibers A8344G mtDNA mutation.
Mesenteric Ischemia
Can heat shock protein 32 be used for the early diagnosis of acute mesenteric ischemia?
Ergothioneine modulates proinflammatory cytokines and heat shock protein 70 in mesenteric ischemia and reperfusion injury.
The value of endoplasmic reticulum stress markers (GRP78 and CHOP) in the diagnosis of acute mesenteric ischemia.
Mesothelioma
(-)- Epigallocatechin-3-gallate induces GRP78 accumulation in the ER and shifts mesothelioma constitutive UPR into proapoptotic ER stress.
A novel mycobacterial Hsp70-containing fusion protein targeting mesothelin augments antitumor immunity and prolongs survival in murine models of ovarian cancer and mesothelioma.
Cytotoxic T cell responses against mesothelioma by apoptotic cell-pulsed dendritic cells.
Functional inhibition of heat shock protein 70 by VER-155008 suppresses pleural mesothelioma cell proliferation via an autophagy mechanism.
HSP90 inhibition alters the chemotherapy-driven rearrangement of the oncogenic secretome.
Increased expression of heat shock protein 70 in adherent ovarian cancer and mesothelioma following treatment with manumycin, a farnesyl transferase inhibitor.
Inhibition of Hsp90 leads to cell cycle arrest and apoptosis in human malignant pleural mesothelioma.
Mesothelial cells activate the plasma kallikrein-kinin system during pleural inflammation.
Mesothelioma cells escape heat stress by upregulating Hsp40/Hsp70 expression via mitogen-activated protein kinases.
Targeted inhibition of multiple receptor tyrosine kinases in mesothelioma.
Mesothelioma, Malignant
HSP90 inhibition alters the chemotherapy-driven rearrangement of the oncogenic secretome.
Inhibition of Hsp90 leads to cell cycle arrest and apoptosis in human malignant pleural mesothelioma.
Metabolic Diseases
Intracellular localization of HSP73 and HSP90 in rat kidneys with acute lysosomal thesaurismosis.
N-Formyl-3,4-methylenedioxy-benzylidene-gamma-butyrolaetam, KNK437 induces caspase-3 activation through inhibition of mTORC1 activity in Cos-1 cells.
Plasma HSP70 Levels Correlate with Health Risk Factors and Insulin Resistance in African American Subjects.
Metabolic Syndrome
A cross-sectional study of the association between heat shock protein 27 antibody titers, pro-oxidant-antioxidant balance and metabolic syndrome in patients with angiographically-defined coronary artery disease.
Clusterin and Its Role in Insulin Resistance and the Cardiometabolic Syndrome.
Improved Metabolic Control in Diabetes, HSP60, and Proinflammatory Mediators.
Metabolic Syndrome and Acute Hyperglycemia Are Associated With Endoplasmic Reticulum Stress in Human Mononuclear Cells.
Mild Electrical Stimulation with Heat Shock Reduces Visceral Adiposity and Improves Metabolic Abnormalities in Subjects with Metabolic Syndrome or Type 2 Diabetes: Randomized Crossover Trials.
Omega-3 fatty acid supplements improve the cardiovascular risk profile of subjects with metabolic syndrome, including markers of inflammation and auto-immunity.
Oxidative stress markers, C-reactive protein and heat shock protein 70 levels in subjects with metabolic syndrome.
Relationship Between Heat Shock Protein Expression and Obesity With and Without Metabolic Syndrome.
The 60- and 70-kDa heat-shock proteins and their correlation with cardiovascular risk factors in postmenopausal women with metabolic syndrome.
The Effects of Curcumin on Serum Heat Shock Protein 27 Antibody Titers in Patients with Metabolic Syndrome.
The effects of wet cupping on serum high-sensitivity C-reactive protein and heat shock protein 27 antibody titers in patients with metabolic syndrome.
Microphthalmos
Hsp90 selectively modulates phenotype in vertebrate development.
Microscopic Polyangiitis
Increased concentrations of antibody against heat shock protein in patients with myeloperoxidase anti-neutrophil cytoplasmic autoantibody positive microscopic polyangiitis.
Migraine Disorders
Elevated interictal serum HSP-70 levels as an indicator of neurodegeneration for chronic migraine.
Exogenous HSP70 attenuates nitroglycerin-induced migraine-like symptoms in mice.
[Herbs for calming liver and suppressing liver-yang in treatment of migraine with hyperactive liver-yang syndrome and its effects on lymphocyte protein expression: a randomized controlled trial]
Milk Hypersensitivity
Prevalence of heat shock protein in patients with Meniere's disease and allergy.
Mitochondrial Diseases
A new case of multiple mitochondrial enzyme deficiencies with decreased amount of heat shock protein 60.
Decreased synthesis and inefficient mitochondrial import of hsp60 in a patient with a mitochondrial encephalomyopathy.
Immunolabelling of mitochondrial superoxide dismutase and of Hsp60 in muscles harbouring a respiratory chain deficiency.
Skd3 (human ClpB) is a potent mitochondrial protein disaggregase that is inactivated by 3-methylglutaconic aciduria-linked mutations.
Spondyloepimetaphyseal dysplasia with neurodegeneration associated with AIFM1 mutation - a novel phenotype of the mitochondrial disease.
Mitochondrial Encephalomyopathies
Decreased synthesis and inefficient mitochondrial import of hsp60 in a patient with a mitochondrial encephalomyopathy.
Mitochondrial Myopathies
Decreased synthesis and inefficient mitochondrial import of hsp60 in a patient with a mitochondrial encephalomyopathy.
Expression of heat-shock/stress proteins in Duchenne muscular dystrophy.
Mixed Connective Tissue Disease
Antibodies to small ribonucleoprotein and to 73-kD heat shock protein: two distinct markers of mixed connective tissue disease.
Antibodies to the constitutive 73-kd heat shock protein: a new marker of mixed connective tissue disease?
Autoantibodies against chaperonin CCT in human sera with rheumatic autoimmune diseases: comparison with antibodies against other Hsp60 family proteins.
Autoantibodies to human stress proteins. A survey of various rheumatic and other inflammatory diseases.
Identification of citrullinated heat shock protein 90 isoforms as novel autoantigens in rheumatoid arthritis-associated interstitial lung disease.
Monoclonal Gammopathy of Undetermined Significance
Expression and release of glucose-regulated protein-78 (GRP78) in multiple myeloma.
STAT3 and MAPK signaling maintain overexpression of heat shock proteins 90alpha and beta in multiple myeloma cells, which critically contribute to tumor-cell survival.
Motor Neuron Disease
Autoantibodies against HSP70 family proteins were detected in the cerebrospinal fluid from patients with multiple sclerosis.
Characterization of human small heat shock protein HSPB1 ?-crystallin domain localized mutants associated with hereditary motor neuron diseases.
Characterization of human small heat shock protein HspB1 that carries C-terminal domain mutations associated with hereditary motor neuron diseases.
Characterization of Mutants of Human Small Heat Shock Protein HspB1 Carrying Replacements in the N-Terminal Domain and Associated with Hereditary Motor Neuron Diseases.
Expression of the human groEL stress-protein homologue in the brain and spinal cord.
Mutant HSPB1 overexpression in neurons is sufficient to cause age-related motor neuronopathy in mice.
Nonsteroidal anti-inflammatory drugs differentially affect the heat shock response in cultured spinal cord cells.
Prevalence of anti-heat shock protein antibodies in cerebrospinal fluids of patients with Guillain-Barré syndrome.
Transcriptional induction of the heat shock protein B8 mediates the clearance of misfolded proteins responsible for motor neuron diseases.
Mouth Neoplasms
Anti-growth and pro-apoptotic effects of dasatinib on human oral cancer cells through multi-targeted mechanisms.
Association of hsp90 to the hTERT promoter is necessary for hTERT expression in human oral cancer cells.
Cell surface expression of 70 kDa heat shock protein in human oral dysplasia and squamous cell carcinoma: correlation with clinicopathological features.
Decreased GRP78 protein expression is a potential prognostic marker of oral squamous cell carcinoma in Taiwan.
Differential gene expression in neoplastic and human papillomavirus-immortalized oral keratinocytes.
Heat Shock Protein 70 Membrane Expression in Oral Cancer: A Possible New Target in Antineoplastic Therapy?
Heat shock protein induced TCR gammadelta gene rearrangements in patients with oral cancer.
Low-level laser therapy can produce increased aggressiveness of dysplastic and oral cancer cell lines by modulation of Akt/mTOR signaling pathway.
Positive association of glucose-regulated protein 78 during oral cancer progression and the prognostic value in oral precancerous lesions.
Prognosis and predictive value of heat-shock proteins expression in oral cancer: A PRISMA-compliant meta-analysis.
Prognostic significance of heat shock protein 70 (HSP70) in patients with oral cancer.
Serum HSP90-Alpha and Oral Squamous Cell Carcinoma : A Prospective Biomarker.
Targeting oral cancer stemness and chemoresistance by isoliquiritigenin-mediated GRP78 regulation.
Movement Disorders
Mortalin inhibition in experimental Parkinson's disease.
The early-onset torsion dystonia-associated protein, torsinA, displays molecular chaperone activity in vitro.
Mucocutaneous Lymph Node Syndrome
Heat shock protein as a predisposing and immunopotentiating factor in Kawasaki disease.
HSP60, HSP70 in the pathogenesis of Kawasaki disease: implication and action.
Increased expression of human 63-kD heat shock protein gene in Kawasaki disease determined by quantitative reverse transcription-polymerase chain reaction.
Levels of intra- and extracellular heat shock protein 60 in Kawasaki disease patients treated with intravenous immunoglobulin.
Serum biomarkers differentiating Kawasaki disease from febrile infections: A pilot case-control study.
T cells recognize an immunodominant epitope of heat shock protein 65 in Kawasaki disease.
Mucormycosis
Anti-CotH3 antibodies protect mice from mucormycosis by prevention of invasion and augmenting opsonophagocytosis.
CotH3 mediates fungal invasion of host cells during mucormycosis.
COVID19 associated mucormycosis: Is GRP78 a possible link?
GRP78 and Integrins Play Different Roles in Host Cell Invasion during Mucormycosis.
The endothelial cell receptor GRP78 is required for mucormycosis pathogenesis in diabetic mice.
Multiple Myeloma
A GRP78-directed monoclonal antibody recaptures response in refractory multiple myeloma with extramedullary involvement.
A phase I/II study of KW-2478, an Hsp90 inhibitor, in combination with bortezomib in patients with relapsed/refractory multiple myeloma.
An activated JAK/STAT3 pathway and CD45 expression are associated with sensitivity to Hsp90 inhibitors in multiple myeloma.
Analysis of expression of heat shock protein-90 (HSP90) and the effects of HSP90 inhibitor (17-AAG) in multiple myeloma.
Anti-myeloma activity of the novel 2-aminothienopyrimidine Hsp90 inhibitor NVP-BEP800.
Anti-tumor activity against multiple myeloma by combination of KW-2478, an Hsp90 inhibitor, with bortezomib.
Antimyeloma activity of heat shock protein-90 inhibition.
Apigenin inhibits proliferation and induces apoptosis in human multiple myeloma cells through targeting the trinity of CK2, Cdc37 and Hsp90.
ATP analog enhances the actions of a HSP90 inhibitor in multiple myeloma cells.
Azacytidine induces necrosis of multiple myeloma cells through oxidative stress.
BIRB 796 enhances cytotoxicity triggered by bortezomib, heat shock protein (Hsp) 90 inhibitor, and dexamethasone via inhibition of p38 mitogen-activated protein kinase/Hsp27 pathway in multiple myeloma cell lines and inhibits paracrine tumour growth.
Bortezomib promotes apoptosis of multiple myeloma cells by regulating HSP27.
Combination mammalian target of rapamycin inhibitor rapamycin and HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin has synergistic activity in multiple myeloma.
Emphasizing on heat shock protein 90's utility in head and neck squamous cell carcinoma treatment.
Glucose-regulated protein 78 (GRP78) as a potential novel biomarker and therapeutic target in multiple myeloma.
GRP78 modulates cell adhesion markers in prostate Cancer and multiple myeloma cell lines.
Heat shock protein-90 inhibitors increase MHC class I-related chain a and B ligand expression on multiple myeloma cells and their ability to trigger NK cell degranulation.
Heat shock proteins in multiple myeloma.
High expression of endoplasmic reticulum chaperone grp94 is a novel molecular hallmark of malignant plasma cells in multiple myeloma.
HSP90 inhibitors as therapy for multiple myeloma.
Hsp90: a novel target for cancer therapy.
IL-6 activated JAK/STAT3 pathway and sensitivity to Hsp90 inhibitors in multiple myeloma.
Inhibition of heat shock protein 90 (HSP90) as a therapeutic strategy for the treatment of myeloma and other cancers.
Inhibition of Heat Shock Protein 90 as a Novel Platform for the Treatment of Cancer.
Inhibition of HSP90 overcomes melphalan resistance through downregulation of Src in multiple myeloma cells.
Intravenous Immunoglobulin G Suppresses Heat Shock Protein (HSP)-70 Expression and Enhances the Activity of HSP90 and Proteasome Inhibitors.
IPI-504, a novel and soluble HSP-90 inhibitor, blocks the unfolded protein response in multiple myeloma cells.
Molecular chaperone gp96 is a novel therapeutic target of multiple myeloma.
Molecular chaperone GRP78 enhances aggresome delivery to autophagosomes to promote drug resistance in multiple myeloma.
Molecularly targeted therapies in multiple myeloma.
New Molecular and Biological Mechanism of Antitumor Activities of KW-2478, a Novel Nonansamycin Heat Shock Protein 90 Inhibitor, in Multiple Myeloma Cells.
Novel biologically based therapies for Waldenstrom's macroglobulinemia.
Novel therapeutic strategies in multiple myeloma: role of the heat shock protein inhibitors.
Phase 1/1B trial of the heat shock protein 90 inhibitor NVP-AUY922 as monotherapy or in combination with bortezomib in patients with relapsed or refractory multiple myeloma.
Preclinical activity of the novel orally bioavailable HSP90 inhibitor NVP-HSP990 against multiple myeloma cells.
Proteasome and heat shock protein 70 (HSP70) inhibitors as therapeutic alternative in multiple myeloma.
Protein kinase CK2 protects multiple myeloma cells from ER stress-induced apoptosis and from the cytotoxic effect of HSP90 inhibition through regulation of the unfolded protein response.
Proteomic and Functional Analyses Reveal a Dual Molecular Mechanism Underlying Arsenic-Induced Apoptosis in Human Multiple Myeloma Cells.
Signalling profile and antitumour activity of the novel Hsp90 inhibitor NVP-AUY922 in multiple myeloma.
SNX-2112, a selective Hsp90 inhibitor, potently inhibits tumor cell growth, angiogenesis, and osteoclastogenesis in multiple myeloma and other hematologic tumors by abrogating signaling via Akt and ERK.
Spliced XBP1 Levels Determine Sensitivity of Multiple Myeloma Cells to Proteasome Inhibitor Bortezomib Independent of the Unfolded Protein Response Mediator GRP78.
Stew in its Own Juice: Protein Homeostasis Machinery Inhibition Reduces Cell Viability in Multiple Myeloma Cell Lines.
Synergistic action of the novel HSP90 inhibitor NVP-AUY922 with histone deacetylase inhibitors, melphalan, or doxorubicin in multiple myeloma.
Synergistic effects of rmhTRAIL and 17-AAG on the proliferation and apoptosis of multiple myeloma cells.
Targeting Akt and heat shock protein 90 produces synergistic multiple myeloma cell cytotoxicity in the bone marrow microenvironment.
Targeting heat shock protein 90 induces apoptosis and inhibits critical survival and proliferation pathways in multiple myeloma.
The 60-kDa heat shock protein regulates energy rearrangement and protein synthesis to promote proliferation of multiple myeloma cells.
The anti-myeloma activity of a novel purine scaffold HSP90 inhibitor PU-H71 is via inhibition of both HSP90A and HSP90B1.
The IMiD target CRBN determines HSP90 activity toward transmembrane proteins essential in multiple myeloma.
The natural human IgM antibody PAT-SM6 induces apoptosis in primary human multiple myeloma cells by targeting heat shock protein GRP78.
The novel, orally bioavailable HSP90 inhibitor NVP-HSP990 induces cell cycle arrest and apoptosis in multiple myeloma cells and acts synergistically with melphalan by increased cleavage of caspases.
The small heat shock protein B8 (HSPB8) confers resistance to bortezomib by promoting autophagic removal of misfolded proteins in multiple myeloma cells.
Transcription inhibition of heat shock proteins: a strategy for combination of 17-allylamino-17-demethoxygeldanamycin and actinomycin d.
[Correlation of HSP90 mRNA Expression with Migration Ability of Human Multiple Myeloma Cells.]
[Expression and Clinical Significance of Heat Shock Protein 90 in Multiple Myeloma Patients].
[Heat shock protein 90 alpha und beta are overexpressed in multiple myeloma cells and critically contribute to survival]
[HSP90 Inhibitor 17-AAG Inhibits Multiple Myeloma Cell Proliferation by Down-regulating Wnt/?-Catenin Signaling Pathway].
[Influence of Co-inhibiting mTORC2 and HSP90 on Proliferation Apoptosis of Multiple Myeloma Cells].
[Research on multiple myeloma cell apoptosis by inhibition of mTORC2 and chaperon pathways].
Multiple Sclerosis
A novel rationale for inhibition of gelatinase B in multiple sclerosis: MMP-9 destroys alpha B-crystallin and generates a promiscuous T cell epitope.
Alpha B-crystallin is not a dominant peripheral T-cell autoantigen in multiple sclerosis amongst Sardinians.
Alpha beta-crystallin expression and presentation following infection with murine gammaherpesvirus 68.
AlphaB-crystallin-reactive T cells from knockout mice are not encephalitogenic.
Anti Mycobacterium avium subsp. paratuberculosis heat shock protein 70 antibodies in the sera of Sardinian patients with multiple sclerosis.
Antibodies reactive to heat shock protein 90 induce oligodendrocyte precursor cell death in culture. Implications for demyelination in multiple sclerosis.
Clinical proteomics in chronic inflammatory diseases: A review.
Clonal expansion and decreased occurrence of peripheral blood gamma delta T cells of the V delta 2J delta 3 lineage in multiple sclerosis patients.
Colocalization of lymphocytes bearing gamma delta T-cell receptor and heat shock protein hsp65+ oligodendrocytes in multiple sclerosis.
CRYAB promoter polymorphisms: influence on multiple sclerosis susceptibility and clinical presentation.
Cytokine induction of heat shock protein expression in human oligodendrocytes: an interleukin-1-mediated mechanism.
DNA vaccine containing the mycobacterial hsp65 gene prevented insulitis in MLD-STZ diabetes.
Epitopes of microbial and human heat shock protein 60 and their recognition in myalgic encephalomyelitis.
Expression of alphaB-crystallin in glia cells during lesional development in multiple sclerosis.
Heat shock protein 27 in multiple sclerosis relapses.
Heat Shock Protein 70 and The Risk of Multiple Sclerosis in The Iranian Population.
Heat shock protein 70 associations with myelin basic protein and proteolipid protein in multiple sclerosis brains.
Heat shock protein 70 gene polymorphism in Japanese patients with multiple sclerosis.
Heat shock protein 70 gene polymorphisms and multiple sclerosis.
Heat shock protein 70-hom gene polymorphism and protein expression in multiple sclerosis.
Heat Shock Protein 70: Roles in Multiple Sclerosis.
High prevalence of anti-alpha-crystallin antibodies in multiple sclerosis: correlation with severity and activity of disease.
Inducible heat shock protein 70 promotes myelin autoantigen presentation by the HLA class II.
Patients with multiple sclerosis resisted to glucocorticoid therapy: abnormal expression of heat-shock protein 90 in glucocorticoid receptor complex.
Phosphorylation of ?B-crystallin supports reactive astrogliosis in demyelination.
Presence and activation of pro-inflammatory macrophages are associated with CRYAB expression in vitro and after peripheral nerve injury.
Relevance of Helicobacter pylori infection in Egyptian multiple sclerosis patients.
Sequence homologies between hsp60 and autoantigens.
Serum heat shock protein 70 levels as a biomarker for inflammatory processes in multiple sclerosis.
Spinal fluid lymphocytes from a subgroup of multiple sclerosis patients respond to mycobacterial antigens.
The heat-shock protein 90 inhibitor 17-allylamino-17-demethoxygeldanamycin suppresses glial inflammatory responses and ameliorates experimental autoimmune encephalomyelitis.
The Reaction of Placental GRP78 Protein with Sera from Women with Multiple Sclerosis.
The small heat shock protein alpha B-crystallin as key autoantigen in multiple sclerosis.
Therapeutic effects of systemic administration of the chaperone alpha B crystallin associated with binding proinflammatory plasma proteins.
Therapeutic Intervention in Multiple Sclerosis with Alpha B-Crystallin: A Randomized Controlled Phase IIa Trial.
Transcriptional profiling of microdissected areas of active multiple sclerosis lesions reveals activation of heat shock protein genes.
Up-regulation of inducible heat shock protein-70 expression in multiple sclerosis patients.
Up-regulation of osteopontin and alphaBeta-crystallin in the normal-appearing white matter of multiple sclerosis: an immunohistochemical study utilizing tissue microarrays.
[Heat shock protein 105 in multiple sclerosis]
Multiple Sclerosis, Chronic Progressive
Relevance of Helicobacter pylori infection in Egyptian multiple sclerosis patients.
Multiple System Atrophy
Accumulation of Hsc70 and Hsp70 in glial cytoplasmic inclusions in patients with multiple system atrophy.
Mumps
Airway Papillomatosis: New Treatments for an Old Challenge.
Heat Shock Protein 70 Regulates Degradation of the Mumps Virus Phosphoprotein via the Ubiquitin-Proteasome Pathway.
Heat Shock Protein 90 Ensures Efficient Mumps Virus Replication by Assisting with Viral Polymerase Complex Formation.
Muscle Spasticity
Inactivation of the hereditary spastic paraplegia-associated Hspd1 gene encoding the Hsp60 chaperone results in early embryonic lethality in mice.
Recombinant osteopontin in cerebral vasospasm after subarachnoid hemorrhage.
The neurodegenerative-disease-related protein sacsin is a molecular chaperone.
Muscle Weakness
Effects of corticosteroids in the development of limb muscle weakness in a porcine intensive care unit model.
Muscular Atrophy
17-AAG, an Hsp90 inhibitor, ameliorates polyglutamine-mediated motor neuron degeneration.
17-DMAG ameliorates polyglutamine-mediated motor neuron degeneration through well-preserved proteasome function in an SBMA model mouse.
A transient antioxidant stress response accompanies the onset of disuse atrophy in human skeletal muscle.
Alleviating neurodegeneration by an anticancer agent: an Hsp90 inhibitor (17-AAG).
Endoplasmic reticulum stress in myotonic dystrophy type 1 muscle.
Estrogen administration attenuates immobilization-induced skeletal muscle atrophy in male rats.
Heat shock cognate protein 70 promotes the differentiation of C2C12 myoblast and targets Yin Yang 1.
Heat shock protein 70 chaperone overexpression ameliorates phenotypes of the spinal and bulbar muscular atrophy transgenic mouse model by reducing nuclear-localized mutant androgen receptor protein.
Hsp40 molecules that target to the ubiquitin-proteasome system decrease inclusion formation in models of polyglutamine disease.
Hsp40 Molecules That Target to the Ubiquitin-proteasome System Decrease Inclusion Formation in Models of Polyglutamine Disease.
Hsp70 prevents disuse muscle atrophy in senescent rats.
Inhibition of Hsp70 by methylene blue affects signaling protein function and ubiquitination and modulates polyglutamine protein degradation.
Mountain ginseng inhibits skeletal muscle atrophy by decreasing muscle RING ?nger protein-1 and atrogin1 through forkhead box O3 in L6 myotubes.
Overexpression of inducible 70-kDa heat shock protein in mouse improves structural and functional recovery of skeletal muscles from atrophy.
Physiological and molecular responses to thermal stress in red cusk-eel (Genypterus chilensis) juveniles reveals atrophy and oxidative damage in skeletal muscle.
Targeting Hsp90/Hsp70-based protein quality control for treatment of adult onset neurodegenerative diseases.
The decrease of the cytoskeleton tubulin follows the decrease of the associating molecular chaperone alphaB-crystallin in unloaded soleus muscle atrophy without stretch.
Trehalose induces autophagy via lysosomal-mediated TFEB activation in models of motoneuron degeneration.
Muscular Atrophy, Spinal
HspB1 silences translation of PDZ-RhoGEF by enhancing miR-20a and miR-128 expression to promote neurite extension.
Muscular Diseases
?B-Crystallin R120G variant causes cardiac arrhythmias and alterations in the expression of Ca(2+) -handling proteins and endoplasmic reticulum stress in mice.
A missense mutation in the alphaB-crystallin chaperone gene causes a desmin-related myopathy.
BAG3 Directly Interacts with Mutated alphaB-Crystallin to Suppress Its Aggregation and Toxicity.
Expression of R120G-alphaB-crystallin causes aberrant desmin and alphaB-crystallin aggregation and cardiomyopathy in mice.
Expression, localization and functional divergence of alphaB-crystallin and heat shock protein 27 in core myopathies and neurogenic atrophy.
Glucocorticoid treatment induces expression of small heat shock proteins in human satellite cell populations: consequences for a desmin-related myopathy involving the R120G alpha B-crystallin mutation.
Homozygous expression of the myofibrillar myopathy-associated p.W2710X filamin C variant reveals major pathomechanisms of sarcomeric lesion formation.
Hsp27 suppresses the formation of inclusion bodies induced by expression of R120G alpha B-crystallin, a cause of desmin-related myopathy.
Infantile onset myofibrillar myopathy due to recessive CRYAB mutations.
Intermediate filament interactions can be altered by HSP27 and alphaB-crystallin.
Loss of ?B-crystallin function in zebrafish reveals critical roles in the development of the lens and stress resistance of the heart.
Modeling human protein aggregation cardiomyopathy using murine induced pluripotent stem cells.
Myopathy in Marinesco-Sjögren syndrome links endoplasmic reticulum chaperone dysfunction to nuclear envelope pathology.
Myopathy-associated alphaB-crystallin mutants: abnormal phosphorylation, intracellular location, and interactions with other small heat shock proteins.
The Human 343delT HSPB5 Chaperone Associated with Early-onset Skeletal Myopathy Causes Defects in Protein Solubility.
The Paradoxical Effect of PARP Inhibitor BGP-15 on Irinotecan-Induced Cachexia and Skeletal Muscle Dysfunction.
Transgenic expression of inclusion body myopathy associated mutant p97/VCP causes weakness and ubiquitinated protein inclusions in mice.
Translocation of molecular chaperones to the titin springs is common in skeletal myopathy patients and affects sarcomere function.
VCP maintains lysosomal homeostasis and TFEB activity in differentiated skeletal muscle.
Muscular Disorders, Atrophic
Hsp70 prevents disuse muscle atrophy in senescent rats.
Muscular Dystrophies
A dual role for HSP90 and HSP70 in the inflammatory myopathies: from muscle fiber protection to active invasion by macrophages.
A novel mechanism of autophagic cell death in dystrophic muscle regulated by P2RX7 receptor large-pore formation and HSP90.
Chaperoning heat shock proteins: Proteomic analysis and relevance for normal and dystrophin-deficient muscle.
Hsp72 preserves muscle function and slows progression of severe muscular dystrophy.
Therapeutic potential of heat shock protein induction for muscular dystrophy and other muscle wasting conditions.
Muscular Dystrophies, Limb-Girdle
Cellular stress stimulates nuclear localization signal (NLS) independent nuclear transport of MRJ.
Myofibrillar disruption and RNA-binding protein aggregation in a mouse model of limb-girdle muscular dystrophy 1D.
Myopathy-causing Mutations in an HSP40 Chaperone Disrupt Processing of Specific Client Conformers.
Muscular Dystrophy, Duchenne
Heat shock protein families 70 and 90 in Duchenne muscular dystrophy and inflammatory myopathy: Balancing muscle protection and destruction.
Myalgia
Leucine-Enriched Essential Amino Acids Improve Recovery from Post-Exercise Muscle Damage Independent of Increases in Integrated Myofibrillar Protein Synthesis in Young Men.
Myasthenia Gravis
Autoimmunity to endoplasmic reticulum chaperone GRP94 in myasthenia gravis.
Heat shock protein 90? in thymic epithelial tumors and non-thymomatous myasthenia gravis.
Hsp60 and AChR cross-reactivity in myasthenia gravis: An update.
Increased skeletal muscle expression of the endoplasmic reticulum chaperone GRP78 in patients with myasthenia gravis.
The mechanism of acetylcholine receptor in binding MuSK in myasthenia gravis and the role of HSP90 molecular chaperone.
The Molecular Anatomy of Human Hsp60 and its Similarity with that of Bacterial Orthologs and Acetylcholine Receptor Reveal a Potential Pathogenetic Role of Anti-Chaperonin Immunity in Myasthenia Gravis.
[Expression of heat shock protein 90 in peripheral blood mononuclear cells of children with myasthenia gravis]
Mycetoma
Streptomyces albus isolated from a human actinomycetoma and characterized by molecular techniques.
Mycoses
A CRISPR Interference Platform for Efficient Genetic Repression in Candida albicans.
Effect of stress on heat shock protein levels, immune response and survival to fungal infection of Mamestra brassicae larvae.
Fungal heat-shock proteins in human disease.
Harnessing Hsp90 function as a powerful, broadly effective therapeutic strategy for fungal infectious disease.
Heat Shock Protein 60, Insights to Its Importance in Histoplasma capsulatum: From Biofilm Formation to Host-Interaction.
Heat shock protein inhibitors for the treatment of fungal infections.
Hsp90 governs echinocandin resistance in the pathogenic yeast Candida albicans via calcineurin.
Inhibition of heat-shock protein 90 enhances the susceptibility to antifungals and reduces the virulence of Cryptococcus neoformans/Cryptococcus gattii species complex.
Mapping the Hsp90 Genetic Network Reveals Ergosterol Biosynthesis and Phosphatidylinositol-4-Kinase Signaling as Core Circuitry Governing Cellular Stress.
PKC signaling regulates drug resistance of the fungal pathogen Candida albicans via circuitry comprised of Mkc1, calcineurin, and Hsp90.
Progress and prospects for targeting Hsp90 to treat fungal infections.
The Hsp90 Chaperone Network Modulates Candida Virulence Traits.
The Hsp90 Co-Chaperone Sgt1 Governs Candida albicans Morphogenesis and Drug Resistance.
The role of antibodies against hsp90 in the treatment of fungal infections.
The role of hsp90 in fungal infection.
Mycosis Fungoides
Expression of heat-shock protein-90 in non-Hodgkin's lymphomas.
Myelodysplastic Syndromes
BIIB021, an Hsp90 inhibitor, effectively kills a myelodysplastic syndrome cell line via the activation of caspases and inhibition of PI3K/Akt and NF-?B pathway proteins.
Expression and prognostic significance of heat-shock proteins in myelodysplastic syndromes.
Heat Shock Protein 90 is overexpressed in high-risk myelodysplastic syndromes and associated with higher expression and activation of Focal Adhesion Kinase.
Mitochondrial Hspa9/Mortalin regulates erythroid differentiation via iron-sulfur cluster assembly.
Reduced levels of Hspa9 attenuate Stat5 activation in mouse B cells.
Myocardial Infarction
Activation of the unfolded protein response in infarcted mouse heart and hypoxic cultured cardiac myocytes.
alphaB-crystallin is phosphorylated during myocardial infarction: involvement of platelet-derived growth factor-BB.
An Aggregate Biomarker Risk Score Predicts High Risk of Near-Term Myocardial Infarction and Death: Findings From BARI 2D (Bypass Angioplasty Revascularization Investigation 2 Diabetes).
Analysis of the association of a heat shock protein70-1 gene promoter polymorphism with myocardial infarction and coronary risk traits.
Antibody response to the 60-kDa heat-shock protein of Chlamydia pneumoniae in patients with coronary artery disease.
Association between plasma levels of heat shock protein 60 and cardiovascular disease in patients with diabetes mellitus.
Atherosclerosis as a paradigmatic disease of the elderly: role of the immune system.
Changes in Hsp60 level of the failing heart following acute myocardial infarction and the effect of long-term treatment with trandolapril.
Characterization of heat shock protein 27 in extracellular vesicles: a potential anti-inflammatory therapy.
Contractile function of rat myocardium is less susceptible to hypoxia/reoxygenation after acute infarction.
Controlled delivery of heat shock protein using an injectable microsphere/hydrogel combination system for the treatment of myocardial infarction.
Drugs, gene transfer, signaling factors: a bench to bedside approach to myocardial stem cell therapy.
Effects of 17-AAG on the RIP1/RIP3/MLKL pathway during the development of heart failure following myocardial infarction in rats.
Effects of heme oxygenase-1 upregulation on isoproterenol-induced myocardial infarction.
Elevated antibody levels against Chlamydia pneumoniae, human HSP60 and mycobacterial HSP65 are independent risk factors in myocardial infarction and ischaemic heart disease.
Elevated circulating levels of heat shock protein 70 are related to systemic inflammatory reaction through monocyte Toll signal in patients with heart failure after acute myocardial infarction.
Elevated heat shock protein 60 levels are associated with higher risk of coronary heart disease in Chinese.
Endothelial HSPA12B Exerts Protection Against Sepsis-Induced Severe Cardiomyopathy via Suppression of Adhesion Molecule Expression by miR-126.
Enhanced Susceptibility to 5-Fluorouracil in Human Colon Cancer Cells by Silencing of GRP78.
Genome-wide association study of myocardial infarction, atrial fibrillation, acute stroke, acute kidney injury and delirium after cardiac surgery - a sub-analysis of the RIPHeart-Study.
Heat shock protein 27 protects the heart against myocardial infarction.
Heat Shock Protein 47 (HSP47) Antisense Oligonucleotides Reduce Cardiac Remodeling and Improve Cardiac Function in a Rat Model of Myocardial Infarction.
Heat shock protein A12B gene therapy improves perfusion, promotes neovascularization, and decreases fibrosis in a murine model of hind limb ischemia.
Heat-shock protein 90 modulates cardiac ventricular hypertrophy via activation of MAPK pathway.
HSP20-mediated cardiomyocyte exosomes improve cardiac function in mice with myocardial infarction by activating Akt signaling pathway.
Hsp60 and heme oxygenase-1 (Hsp32) in acute myocardial infarction.
Immune-mediated mechanisms of endothelial damage in atherosclerosis.
Implications of antibodies to heat-shock proteins in ischemic heart disease.
Induction of heat shock protein 72 in the failing heart is attenuated after an exposure to heat shock.
Injectable microsphere/hydrogel hybrid system containing heat shock protein as therapy in a murine myocardial infarction model.
Involvement of HSP90 in ischemic postconditioning-induced cardioprotection by inhibition of the complement system, JNK and inflammation.
Lipopolysaccharide pretreatment attenuates myocardial infarct size: A possible mechanism involving heat shock protein 70-inhibitory kappaBalpha complex and attenuation of nuclear factor kappaB.
Low-dose sevoflurane inhalation enhances late cardioprotection from the anti-ulcer drug geranylgeranylacetone.
Morphine Reduces Myocardial Infarct Size via Heat Shock Protein 90 in Rodents.
Myocardial injury leads to a release of heat shock protein (hsp) 60 and a suppression of the anti-hsp65 immune response.
Myocardial ischaemia and the inflammatory response: release of heat shock protein 70 after myocardial infarction.
Oral bimoclomol elevates heat shock protein 70 and reduces myocardial infarct size in rats.
Oral pretreatment with ebselen enhances heat shock protein 72 expression and reduces myocardial infarct size.
Pathway-Specific Aggregate Biomarker Risk Score Is Associated With Burden of Coronary Artery Disease and Predicts Near-Term Risk of Myocardial Infarction and Death.
Pharmacological postconditioning with atorvastatin calcium attenuates myocardial ischemia/reperfusion injury in diabetic rats by phosphorylating GSK3?.
Possible involvement of phosphorylated heat-shock factor-1 in changes in heat shock protein 72 induction in the failing rat heart following myocardial infarction.
Protective effect of geranylgeranylacetone via enhanced induction of HSPB1 and HSPB8 in mitochondria of the failing heart following myocardial infarction in rats.
Recombinant human erythropoietin pretreatment attenuates myocardial infarct size: a possible mechanism involves heat shock Protein 70 and attenuation of nuclear factor-kappaB.
Regional distribution of HSP70 proteins after myocardial infarction.
Regulation of A-Kinase-Anchoring Protein 12 by Heat Shock Protein A12B to Prevent Ventricular Dysfunction Following Acute Myocardial Infarction in Diabetic Rats.
Role of heat shock protein 90 and endothelial nitric oxide synthase during early anesthetic and ischemic preconditioning.
Targeted Delivery of Recombinant Heat Shock Protein 27 to Cardiomyocytes Promotes Recovery from Myocardial Infarction.
Transforming growth factor-?-activated kinase 1 enhances H2O2-induced apoptosis independently of reactive oxygen species in cardiomyocytes.
[The significance of the changes in expressions of heat shock protein 70 and hemeoxygenase-1 in the myocardium in patients died suddenly due to acute myocardial infarction]
Myocardial Ischemia
Acute Chlamydia pneumoniae infection with heat-shock-protein-60-related response in patients with acute coronary syndrome.
Effects of protein transduction domain (PTD) selection and position for improved intracellular delivery of PTD-Hsp27 fusion protein formulations.
Heat shock protein 70 protects cardiomyocytes through suppressing SUMOylation and nucleus translocation of phosphorylated eukaryotic elongation factor 2 during myocardial ischemia and reperfusion.
Heat shock proteins in myocardial stress.
Implications of antibodies to heat-shock proteins in ischemic heart disease.
Increased resistance to myocardial ischemia in the Brown Norway vs. Dahl S rat: role of nitric oxide synthase and Hsp90.
MAPKAPK-2 modulates p38-MAPK localization and small heat shock protein phosphorylation but does not mediate the injury associated with p38-MAPK activation during myocardial ischemia.
Myocardial heat shock gene expression in pigs is dependent on superoxide anion generated at reperfusion.
Myocardial injury leads to a release of heat shock protein (hsp) 60 and a suppression of the anti-hsp65 immune response.
Myocardial ischemia activates an injurious innate immune signaling via cardiac heat shock protein 60 and Toll-like receptor 4.
Myocardial TLR4 is a determinant of neutrophil infiltration after global myocardial ischemia: mediating KC and MCP-1 expression induced by extracellular HSC70.
Nitric oxide induces heat shock protein 72 production and delayed protection against myocardial ischemia in rabbits via activating protein kinase C.
Prolongation and enhancement of the anti-apoptotic effects of PTD-Hsp27 fusion proteins using an injectable thermo-reversible gel in a rat myocardial infarction model.
Rapid expression of heat shock protein in the rabbit after brief cardiac ischemia.
Myocardial Reperfusion Injury
Heat shock protein 90 transfection reduces ischemia-reperfusion-induced myocardial dysfunction via reciprocal endothelial NO synthase serine 1177 phosphorylation and threonine 495 dephosphorylation.
Myocarditis
Endoplasmic Reticulum Stress Aggravates Viral Myocarditis by Raising Inflammation Through the IRE1-Associated NF-?B Pathway.
Heat stress aggravates viral myocarditis in mice.
[Effect of total flavonoids of astragalus on endoplasmic reticulum chaperone, calumenin and connecxin 43 in suckling mouse myocardium with myocarditis caused by coxsackievirus B3].
[Effects of total flavonids of astragalus on arrhythmia,endoplasmic reticulum stress in mice with viral myocarditis].
Myoma
Decreased expression of human heat shock protein 70 in the endometria and pathological lesions of women with adenomyosis and uterine myoma after GnRH agonist therapy.
Expression of the 60 kDa heat shock protein in peritoneal fluids from women with endometriosis: implications for endometriosis-associated infertility.
Myopathies, Nemaline
KLHL41 stabilizes skeletal muscle sarcomeres by nonproteolytic ubiquitination.
Myositis
A dual role for HSP90 and HSP70 in the inflammatory myopathies: from muscle fiber protection to active invasion by macrophages.
AlphaB-crystallin immunolocalization yields new insights into inclusion body myositis.
Heat shock protein families 70 and 90 in Duchenne muscular dystrophy and inflammatory myopathy: Balancing muscle protection and destruction.
Increased skeletal muscle expression of the endoplasmic reticulum chaperone GRP78 in patients with myasthenia gravis.
Myofiber stress-response in myositis: parallel investigations on patients and experimental animal models of muscle regeneration and systemic inflammation.
[Expression of the heat shock protein 70 in inflammatory myopathies]
Myositis, Inclusion Body
A dual role for HSP90 and HSP70 in the inflammatory myopathies: from muscle fiber protection to active invasion by macrophages.
AlphaB-crystallin immunolocalization yields new insights into inclusion body myositis.
Myotonia
Endoplasmic reticulum stress in myotonic dystrophy type 1 muscle.
Myotonic Dystrophy
HspB2/myotonic dystrophy protein kinase binding protein (MKBP) as a novel molecular chaperone: structural and functional aspects.
MKBP, a novel member of the small heat shock protein family, binds and activates the myotonic dystrophy protein kinase.
Regulation of the mouse alfaB-crystallin and MKBP/HspB2 promoter activities by shared and gene specific intergenic elements: the importance of context dependency.
The sperm outer dense fiber protein is the 10th member of the superfamily of mammalian small stress proteins.
Transient up-regulation of myotonic dystrophy protein kinase-binding protein, MKBP, and HSP27 in the neonatal myocardium.
Myxedema
Methimazole and propylthiouracil inhibit the oxygen free radical-induced expression of a 72 kilodalton heat shock protein in Graves' retroocular fibroblasts.
nadh:ubiquinone reductase (h+-translocating) deficiency
FOXRED1, encoding an FAD-dependent oxidoreductase complex-I-specific molecular chaperone, is mutated in infantile-onset mitochondrial encephalopathy.
Nasopharyngeal Carcinoma
A novel Hsp90 inhibitor AT13387 induces senescence in EBV-positive nasopharyngeal carcinoma cells and suppresses tumor formation.
Clinical and biological significances of heat shock protein 90 (Hsp90) in human nasopharyngeal carcinoma cells and anti-cancer effects of Hsp90 inhibitor.
Elevated HSP90 associates with expression of HIF-1? and p-AKT and is predictive of poor prognosis in nasopharyngeal carcinoma.
Expression of heat shock protein 70 in nasopharyngeal carcinomas: different expression patterns correlate with distinct clinical prognosis.
FM807, a curcumin analogue, shows potent antitumor effects in nasopharyngeal carcinoma cells by heat shock protein 90 inhibition.
Genetic association of promoter in GRP78 gene with nasopharyngeal carcinoma in a Chinese population.
Heat Shock Protein 90? Provides an Effective and Novel Diagnosis Strategy for Nasopharyngeal Carcinoma.
Identification of heat shock protein 27 as a radioresistance-related protein in nasopharyngeal carcinoma cells.
Increased expression of heat shock protein (HSP) 10 and HSP70 correlates with poor prognosis of nasopharyngeal carcinoma.
Intracell Heat Shock Protein 70 Expression and Nasopharyngeal Carcinoma Stage.
miR?495 enhances the efficacy of radiotherapy by targeting GRP78 to regulate EMT in nasopharyngeal carcinoma cells.
Modulatory effects of tumor-derived heat shock protein in DNA vaccination against nasopharyngeal carcinoma.
Polymorphism of the stress protein HSP70-2 gene is associated with the susceptibility to the nasopharyngeal carcinoma.
Recombinant adeno-associated virus encoding Epstein-Barr virus latent membrane proteins fused with heat shock protein as a potential vaccine for nasopharyngeal carcinoma.
[Autophagy inhibitor 3-methyladenine enhances the sensitivity of nasopharyngeal carcinoma cells to chemotherapy and radiotherapy].
[Construction of mammalian co-expression plasmid pIRES -LMP1-HSP90 beta and its expression in vitro]
[Correlation of heat shock protein 70 expression in nasopharyngeal carcinoma to immunoglobin A against viral capsid antigen of Epstein-Barr virus in sera and its clinical significance]
[Expression of main heat stress proteins and p53 in nasopharyngeal carcinoma]
Nasopharyngeal Neoplasms
Co-Inhibition of HSP70/HSP90 Synergistically Sensitizes Nasopharyngeal Carcinoma Cells to Thermotherapy.
Inhibition of Heat Shock Protein 90 suppresses TWIST1 Transcription.
Nematode Infections
Hsp90 Inhibitors in Parasitic Nematodes: Prospects and Challenges.
Neoplasm Metastasis
?7 helix region of ?I domain is crucial for integrin binding to endoplasmic reticulum chaperone gp96: a potential therapeutic target for cancer metastasis.
?B-crystallin Expression in Breast Cancer is Associated with Brain Metastasis.
A Critical Role for GRP78/BiP in the Tumor Microenvironment for Neovascularization during Tumor Growth and Metastasis.
A new tumor-specific variant of GRP78 as target for antibody-based therapy.
A secreted Heat shock protein 90 of Trichomonas vaginalis.
A small molecule cell-impermeant Hsp90 antagonist inhibits tumor cell motility and invasion.
Acidic microenvironment plays a key role in human melanoma progression through a sustained exosome mediated transfer of clinically relevant metastatic molecules.
Alkaloid derivative ION-31a inhibits breast cancer metastasis and angiogenesis by targeting HSP90?.
Analysis of polypeptide expression in benign and malignant human breast lesions.
Andrographolide and its analogues: versatile bioactive molecules for combating inflammation and cancer.
Association of elevated GRP78 expression with increased lymph node metastasis and poor prognosis in patients with gastric cancer.
Association of mortalin (HSPA9) with liver cancer metastasis and prediction for early tumor recurrence.
Autoantibodies against glucose-regulated protein 78 as serological biomarkers in metastatic and recurrent hepatocellular carcinoma.
Bacterial production and functional characterization of the Fab fragment of the murine IgG1/lambda monoclonal antibody cmHsp70.1, a reagent for tumour diagnostics.
Bag-3 expression is involved in pathogenesis and progression of colorectal carcinomas.
BAG3 directly associates with guanine nucleotide exchange factor of Rap1, PDZGEF2, and regulates cell adhesion.
Benzoquinone ansamycin heat shock protein 90 inhibitors modulate multiple functions required for tumor angiogenesis.
Betulinic Acid Suppresses Breast Cancer Metastasis by Targeting GRP78-Mediated Glycolysis and ER Stress Apoptotic Pathway.
Blocking heat shock protein-90 inhibits the invasive properties and hepatic growth of human colon cancer cells and improves the efficacy of oxaliplatin in p53-deficient colon cancer tumors in vivo.
Blocking HSP90 Addiction Inhibits Tumor Cell Proliferation, Metastasis Development, and Synergistically Acts with Zoledronic Acid to Delay Osteosarcoma Progression.
Breast cancer metastasis suppressor 1 (BRMS1) is stabilized by the Hsp90 chaperone.
C-terminal HSP90 inhibitor L80 elicits anti-metastatic effects in triple-negative breast cancer via STAT3 inhibition.
Can breast cancer Hsp 27 (Heat Shock Protein 27000) expression influence axillary lymph node status?
Casein kinase 2 phosphorylation of Hsp90 threonine 22 modulates chaperone function and drug sensitivity.
Characterization and prognostic significance of mortalin, Bcl-2 and Bax in intrahepatic cholangiocarcinoma.
Chemotherapy Controls Metastasis Through Stimulatory Effects on GRP78 and Its Transcription Factor CREB3L1.
CHIP functions as a novel suppressor of tumour angiogenesis with prognostic significance in human gastric cancer.
Clinical development of 17-allylamino, 17-demethoxygeldanamycin.
Clinical Implications of HSC70 Expression in Clear Cell Renal Cell Carcinoma.
Colon cancer cells expressing cell surface GRP78 as a marker for reduced tumorigenicity.
Comparison of the expression of 5 heat shock proteins in benign and malignant salivary gland tumor tissues.
Concomitant high expression of ER?36, GRP78 and GRP94 is associated with aggressive papillary thyroid cancer behavior.
CRIPTO and its signaling partner GRP78 drive the metastatic phenotype in human osteotropic prostate cancer.
Curcumin inhibits lung cancer cell invasion and metastasis through the tumor suppressor HLJ1.
Curcumin suppresses proliferation and invasion in non-small cell lung cancer by modulation of MTA1-mediated Wnt/?-catenin pathway.
De-acetylation and degradation of HSPA5 is critical for E1A metastasis suppression in breast cancer cells.
Decreased GRP78 protein expression is a potential prognostic marker of oral squamous cell carcinoma in Taiwan.
Design and synthesis of pyrimidinyl acyl thioureas as novel Hsp90 inhibitors in invasive ductal breast cancer and its bone metastasis.
Design, Synthesis, and Evaluation of Heat Shock Protein 90 Inhibitors in Human Breast Cancer and Its Metastasis.
Diagnostic, clinicopathologic, therapeutic and prognostic value of Plasma Heat Shock Protein 90 levels in patients with advanced Gastrointestinal Carcinoma.
Different expression of CD44, ICAM-1, and HSP60 on primary tumor and metastases of a human pancreatic carcinoma growing in scid mice.
Down-Regulated Expression of HSP70 in Correlation with Clinicopathology of Cholangiocarcinoma.
Drug-Like Small Molecule HSP27 Functional Inhibitor Sensitizes Lung Cancer Cells to Gefitinib or Cisplatin by Inducing Altered Cross-Linked Hsp27 Dimers.
Effect of heat-shock protein-90 (HSP90) inhibition on human hepatocytes and on liver regeneration in experimental models.
Effect of hypoxia on the expression of alphaB-crystallin in head and neck squamous cell carcinoma.
Effects of Hsp90 inhibition in neuroblastoma: analysis of drug sensitivity, target modulation and the influence of bone marrow microenvironment.
Elevated HSP90 associates with expression of HIF-1? and p-AKT and is predictive of poor prognosis in nasopharyngeal carcinoma.
Elevated levels of mortalin expression in human brain tumors.
Elevated Mortalin correlates with poor outcome in hepatocellular carcinoma.
Elucidation of antiangiogenic potential of Vitexin obtained from Cucumis sativus targeting Hsp90 protein: A novel multipathway targeted approach to restrain angiogenic phenomena.
Emerging Roles of Extracellular Hsp90 in Cancer.
Endoplasmic reticulum chaperone glucose-regulated protein 78 in gastric cancer: An emerging biomarker.
Endoplasmic Reticulum-resident Heat Shock Protein 90 (HSP90) Isoform Glucose-regulated Protein 94 (GRP94) Regulates Cell Polarity and Cancer Cell Migration by Affecting Intracellular Transport.
Enhanced Susceptibility to 5-Fluorouracil in Human Colon Cancer Cells by Silencing of GRP78.
Erythroid Differentiation Regulator 1, an Interleukin 18-Regulated Gene, Acts as a Metastasis Suppressor in Melanoma.
Estrogen receptor-?36-mediated rapid estrogen signaling regulates 78 kDa glucose-regulated protein expression in gastric carcinoma cells.
Expression and significance of glucose-regulated protein 78 in human osteosarcoma.
Expression of glucose regulated protein 78 (GRP78) determines colorectal cancer response to chemotherapy.
Expression of glucose-regulated protein 78 as prognostic biomarkers for triple-negative breast cancer.
Expression of glucose-regulated stress protein GRP78 is related to progression of melanoma.
Expression of GRP78 predicts taxane-based therapeutic resistance and recurrence of human gastric cancer.
Expression of Heat Shock Protein 27 in Melanoma Metastases Is Associated with Overall Response to Bevacizumab Monotherapy: Analyses of Predictive Markers in a Clinical Phase II Study.
Expression of heat shock proteins (HSP27, HSP60, HSP70, HSP90, GRP78, GRP94) in hepatitis B virus-related hepatocellular carcinomas and dysplastic nodules.
Expression of major heat shock proteins in prostate cancer: correlation with clinicopathological outcomes in patients undergoing radical prostatectomy.
Expression of the CD117, COX-2 and HSP90 antigens and cell proliferation in fine-needle-aspirated cells from metastatic melanomas.
Expression of the heat shock cognate protein HSP73 correlates with tumour thickness of primary melanomas and is enhanced in melanoma metastases.
Expression pattern of heat shock protein 90 in patients with oral squamous cell carcinoma in northern Taiwan.
Expressions of GRP78 and Bax associate with differentiation, metastasis, and apoptosis in non-small cell lung cancer.
Extracellular heat shock protein 90: a role for a molecular chaperone in cell motility and cancer metastasis.
Extracellular Hsp70 Reduces the Pro-Tumor Capacity of Monocytes/Macrophages Co-Cultivated with Cancer Cells.
Extracellular HSP70/HSP70-PCs regulate hepatocarcinoma cell migration and invasion via RhoA.
Extracellular Hsp90 (eHsp90) as the Actual Target in Clinical Trials: Intentionally or Unintentionally.
Extracellular Hsp90 and TGF? regulate adhesion, migration and anchorage independent growth in a paired colon cancer cell line model.
Extracellular HSP90: conquering the cell surface.
Extracellular Hsp90? and clusterin synergistically promote breast cancer epithelial-to-mesenchymal transition and metastasis via LRP1.
FOXP2 promotes tumor proliferation and metastasis by targeting GRP78 in triple-negative breast cancer.
FRMD4A upregulation in human squamous cell carcinoma promotes tumor growth and metastasis and is associated with poor prognosis.
Functional pathways shared by liver and lung metastases: a mitochondrial chaperone machine is up-regulated in soft-tissue breast cancer metastasis.
GALNT6 promotes invasion and metastasis of human lung adenocarcinoma cells through O-glycosylating chaperone protein GRP78.
Geldanamycin and its derivatives as Hsp90 inhibitors.
Gene expression profile of renal cell carcinoma clear cell type.
Glucose regulated protein 78 promotes cell invasion via regulation of uPA production and secretion in colon cancer cells.
Glucose regulated protein 78: A critical link between tumor microenvironment and cancer hallmarks.
Glucose-regulated protein 78 (GRP78) regulates colon cancer metastasis through EMT biomarkers and the NRF-2/HO-1 pathway.
Glucose-regulated protein GRP78 is up-regulated in prostate cancer and correlates with recurrence and survival.
GRP75-mediated upregulation of HMGA1 stimulates stage I lung adenocarcinoma progression by activating JNK/c-JUN signaling.
GRP78 activates the Wnt/HOXB9 pathway to promote invasion and metastasis of hepatocellular carcinoma by chaperoning LRP6.
GRP78 and GAL3, differentially regulated by lymph node homogenates, as potential biomarkers for lymph node metastasis in mouse hepatocellular carcinoma cells.
GRP78 enabled micelle-based glioma targeted drug delivery.
GRP78 expression in tumor and perinephric adipose tissue is not an optimal risk stratification marker for clear cell renal cell carcinoma.
GRP78 induction in cancer: therapeutic and prognostic implications.
GRP78 plays an integral role in tumor cell inflammation-related migration induced by M2 macrophages.
GRP78-targeting subtilase cytotoxin sensitizes cancer cells to photodynamic therapy.
HDAC6: Physiological function and its selective inhibitors for cancer treatment.
Heat Shock protein 27 (HSP27, HSPB1) is synthetic lethal to cells with oncogenic activation of MET, EGFR and BRAF.
Heat Shock Protein 27 as a New Therapeutic Target for Radiation Sensitization of Head and Neck Squamous Cell Carcinoma.
Heat shock protein 27 overexpression in breast cancer lymph node metastasis.
Heat shock protein 27: a potential biomarker of peritoneal metastasis in epithelial ovarian cancer?
Heat shock protein 60 overexpression is associated with the progression and prognosis in gastric cancer.
Heat shock protein 70 downregulation inhibits proliferation, migration and tumorigenicity in hepatocellular carcinoma cells.
Heat shock protein 70 membrane expression and melanoma-associated marker phenotype in primary and metastatic melanoma.
Heat shock protein B6 potently increases non-small cell lung cancer growth.
Heat shock protein expression in canine malignant mammary tumours.
Heat Shock Protein-Peptide and HSP-Based Immunotherapies for the Treatment of Cancer.
Heat shock proteins and cancer: intracellular chaperones or extracellular signalling ligands?
Heat shock protein 90 as a molecular target for therapy in oral squamous cell carcinoma: Inhibitory effects of 17?DMAG and ganetespib on tumor cells.
Heat-shock protein 90 (Hsp90) as a molecular target for therapy of gastrointestinal cancer.
Heat-shock protein 90 inhibitors as antitumor agents: a survey of the literature from 2005 to 2010.
Hepatitis B virus X protein upregulates HSP90alpha expression via activation of c-Myc in human hepatocarcinoma cell line, HepG2.
High expression of glucose-regulated protein 78 (GRP78) is associated with metastasis and poor prognosis in patients with esophageal squamous cell carcinoma.
High Expression of GRP78 Promotes Invasion and Metastases in Patients with Esophageal Squamous Cell Carcinoma.
High expression of heat shock protein 90 is associated with tumor aggressiveness and poor prognosis in patients with advanced gastric cancer.
High Levels of Hsp90 Cochaperone p23 Promote Tumor Progression and Poor Prognosis in Breast Cancer by Increasing Lymph Node Metastases and Drug Resistance.
Histone deacetylase 6 in cancer.
HN1L promotes migration and invasion of breast cancer by up-regulating the expression of HMGB1.
HSP20 Exerts a Protective Effect on Preeclampsia by Regulating Function of Trophoblast Cells Via Akt Pathways.
HSP27 expression levels are associated with the sensitivity of hepatocellular carcinoma cells to 17-allylamino-17-demethoxygeldanamycin.
HSP40 co-chaperone protein Tid1 suppresses metastasis of head and neck cancer by inhibiting Galectin-7-TCF3-MMP9 axis signaling.
HSP60 in cancer: a promising biomarker for diagnosis and a potentially useful target for treatment.
HSP70 promotes tumor progression by stabilizing Skp2 expression in gastric cancer cells.
HSP70 vaccine in combination with gene therapy with plasmid DNA encoding sPD-1 overcomes immune resistance and suppresses the progression of pulmonary metastatic melanoma.
HSP90 and HSP70 are essential for stabilization and activation of the WASF3 metastasis promoting protein.
HSP90 as a new therapeutic target for cancer therapy: the story unfolds.
Hsp90 binds directly to fibronectin (FN) and inhibition reduces the extracellular fibronectin matrix in breast cancer cells.
Hsp90 C-Terminal Inhibitors Exhibit Antimigratory Activity by Disrupting the Hsp90?/Aha1 Complex in PC3-MM2 Cells.
HSP90 expression and early recurrence in gastroenteropancreatic neuroendocrine tumors: Potential for a novel therapeutic target.
Hsp90 is an essential regulator of EphA2 receptor stability and signaling: implications for cancer cell migration and metastasis.
Hsp90 phosphorylation, Wee1, and the cell cycle.
Hsp90: a novel target for the disruption of multiple signaling cascades.
Hypoxia Enhances Lysophosphatidic Acid Responsiveness in Ovarian Cancer Cells and Lysophosphatidic Acid Induces Ovarian Tumor Metastasis In vivo.
Identification and Comparison of Differentiation-Related Proteins in Hepatocellular Carcinoma Tissues by Proteomics.
Identification of breast cancer metastasis-associated proteins in an isogenic tumor metastasis model using two-dimensional gel electrophoresis and liquid chromatography-ion trap-mass spectrometry.
Identification of heat shock protein 90? as an IMH-2 epitope-associated protein and correlation of its mRNA overexpression with colorectal cancer metastasis and poor prognosis.
Identification of the Transmembrane Glucose Regulated Protein 78 as a Biomarker for the Brain Cancer Glioblastoma Multiforme by Gene Expression and Proteomic Studies.
IGFBP2 plays an important role in heat shock protein 27-mediated cancer progression and metastasis.
Immunohistochemical expression of Hsp60 correlates with tumor progression and hormone resistance in prostate cancer.
Immunotherapy of radioresistant mammary tumors with early metastasis using molecular chaperone vaccines combined with ionizing radiation.
Impact of heat-shock protein 90 on cancer metastasis.
In silico screening and exploration into phenotypic alterations of deleterious oncogenic single nucleotide polymorphisms in HSPB1 gene.
Increased expression of heat shock protein 27 correlates with peritoneal metastasis in epithelial ovarian cancer.
Indolylkojyl methane analogue IKM5 potentially inhibits invasion of breast cancer cells via attenuation of GRP78.
Inducible heat shock protein 70 expression as a potential predictive marker of metastasis in breast tumors.
Inducible HSP70 antagonizes cisplatin?induced cell apoptosis through inhibition of the MAPK signaling pathway in HGC?27 cells.
Induction of heat shock protein 27 by hydroxyurea and its relationship to experimental metastasis.
Induction of Hsp90 protein expression in malignant melanomas and melanoma metastases.
Inhibition of Cancer Invasion and Metastasis by Targeting the Molecular Chaperone Heat-shock Protein 90.
Inhibition of Established Micrometastases by Targeted Drug Delivery via Cell Surface Associated GRP78.
Inhibition of Heat Shock Protein 90 suppresses TWIST1 Transcription.
Interaction between HSP60 and {beta}-catenin promotes metastasis.
Is co-expression of USP22 and HSP90 more effective in predicting prognosis of gastric cancer?
iTRAQ Quantitative Proteomic Comparison of Metastatic and Non-Metastatic Uveal Melanoma Tumors.
Knockdown of lncRNA ZNRD1-AS1 suppresses gastric cancer cell proliferation and metastasis by targeting the miR-9-5p/HSP90AA1 axis.
Long noncoding RNA DANCR promotes colorectal cancer proliferation and metastasis via miR-577 sponging.
Low dose geldanamycin inhibits hepatocyte growth factor and hypoxia-stimulated invasion of cancer cells.
Low dose HSP90 inhibition with AUY922 blunts rapid evolution of metastatic and drug resistant phenotypes induced by TGF-? and paclitaxel in A549 cells.
Mathematical modelling of the influence of heat shock proteins on cancer invasion of tissue.
MDA-9 and GRP78 as potential diagnostic biomarkers for early detection of melanoma metastasis.
Megakaryocytes mediate hyperglycemia-induced tumor metastasis.
Metabolic stress regulates cytoskeletal dynamics and metastasis of cancer cells.
Metastasis and the Tumor Microenvironment: A Joint Metastasis Research Society-AACR Conference - Research on Metastasis: Part 2.
Methylglyoxal, a glycolysis side-product, induces Hsp90 glycation and YAP-mediated tumor growth and metastasis.
Microvessel density, expression of proto-oncogenes, resistance-related proteins and incidence of metastases in primary ovarian carcinomas.
Mitochondrial chaperone, TRAP1 modulates mitochondrial dynamics and promotes tumor metastasis.
Molecular chaperones as regulators of cell death.
Molecular characterization of hsp90 isoforms in colorectal cancer cells and its association with tumour progression.
Molecular mechanism and targeted therapy of Hsp90 involved in lung cancer: New discoveries and developments (Review).
Monoclonal antibody 4C5 immunostains human melanomas and inhibits melanoma cell invasion and metastasis.
Monoclonal antibody 4C5 prevents activation of MMP2 and MMP9 by disrupting their interaction with extracellular HSP90 and inhibits formation of metastatic breast cancer cell deposits.
Monoclonal Antibody against Cell Surface GRP78 as a Novel Agent in Suppressing PI3K/AKT Signaling, Tumor Growth and Metastasis.
Mortalin expression in pancreatic cancer and its clinical and prognostic significance.
Mortalin overexpression predicts poor prognosis in early stage of non-small cell lung cancer.
Mortalin promotes breast cancer malignancy.
Mortalin promotes cell proliferation and epithelial mesenchymal transition of intrahepatic cholangiocarcinoma cells in vitro.
Mortaparib, a novel dual inhibitor of mortalin and PARP1, is a potential drug candidate for ovarian and cervical cancers.
N,N'-dinitrosopiperazine--mediated heat-shock protein 70-2 expression is involved in metastasis of nasopharyngeal carcinoma.
Nanoparticles inhibit cancer cell invasion and enhance antitumor efficiency by targeted drug delivery via cell surface-related GRP78.
Nck-associated protein 1 associates with HSP90 to drive metastasis in human non-small-cell lung cancer.
Neoisoliquiritigenin inhibits tumor progression by targeting GRP78-?-catenin signaling in breast cancer.
New developments in Hsp90 inhibitors as anti-cancer therapeutics: mechanisms, clinical perspective and more potential.
New novobiocin analogues as antiproliferative agents in breast cancer cells and potential inhibitors of heat shock protein 90.
NHF-derived carbon dots: prevalidation approach in breast cancer treatment.
NMS-E973, a novel synthetic inhibitor of Hsp90 with activity against multiple models of drug resistance to targeted agents, including intracranial metastases.
Novel C-terminal heat shock protein 90 inhibitors target breast cancer stem cells and block migration, self-renewal, and epithelial-mesenchymal transition.
Novel serum markers HSP60, CHI3L1, and IGFBP-2 in metastatic colorectal cancer.
Nuclear Accumulation of Heat-shock Protein 90 Is Associated with Poor Survival and Metastasis in Patients with Non-small Cell Lung Cancer.
Nuclear heat shock protein 110 expression is associated with poor prognosis and hyperthermo-chemotherapy resistance in gastric cancer patients with peritoneal metastasis.
NVP-AUY922: a novel heat shock protein 90 inhibitor active against xenograft tumor growth, angiogenesis, and metastasis.
NZ28-induced inhibition of HSF1, SP1 and NF-?B triggers the loss of the natural killer cell-activating ligands MICA/B on human tumor cells.
ORAOV1-B Promotes OSCC Metastasis via the NF-?B-TNF? Loop.
Organ-specific efficacy of HSP90 inhibitor in multiple-organ metastasis model of chemorefractory small cell lung cancer.
Overexpressed GRP78 affects EMT and cell-matrix adhesion via autocrine TGF-?/Smad2/3 signaling.
Overexpression of GRP78 and GRP94 are markers for aggressive behavior and poor prognosis in gastric carcinomas.
Overexpression of GRP78 and GRP94 is involved in colorectal carcinogenesis.
Overexpression of Mortalin in hepatocellular carcinoma and its relationship with angiogenesis and epithelial to mesenchymal transition.
Patterns of heat shock protein (HSP70) expression and Kupffer cell activity following thermal ablation of liver and colorectal liver metastases.
Plasma levels of heat shock protein 90 alpha associated with lung cancer development and treatment responses.
PLC?1-PKC? signaling-mediated Hsp90? plasma membrane translocation facilitates tumor metastasis.
PNSA, a Novel C-Terminal Inhibitor of HSP90, Reverses Epithelial-Mesenchymal Transition and Suppresses Metastasis of Breast Cancer Cells In Vitro.
Preoperative heat shock protein 47 levels identify colorectal cancer patients with lymph node metastasis and poor prognosis.
Probing the ATP Site of GRP78 with Nucleotide Triphosphate Analogs.
Proteomics analysis of differential protein expression identifies heat shock protein 47 as a predictive marker for lymph node metastasis in patients with colorectal cancer.
Quantitative score modulation of HSP90 and HSP27 in clear cell renal cell carcinoma.
Relationship between the expression of phosphorylated heat shock protein beta-1 with lymph node metastases of breast cancer.
Retinal toxicity induced by small-molecule Hsp90 inhibitors in beagle dogs.
Role of acetylation and extracellular location of heat shock protein 90alpha in tumor cell invasion.
Role of HSP60/HSP10 in Lung Cancer: Simple Biomarkers or Leading Actors?
Secreted heat shock protein 90 promotes prostate cancer stem cell heterogeneity.
Secreted Hsp90 is a novel regulator of the epithelial to mesenchymal transition (EMT) in prostate cancer.
Secretion of extracellular hsp90alpha via exosomes increases cancer cell motility: a role for plasminogen activation.
Serum level of soluble 70-kD heat shock protein is associated with high mortality in patients with colorectal cancer without distant metastasis.
Significance of expression of heat shock protein90alpha in human gastric cancer.
Silencing Heat Shock Protein 27 Inhibits the Progression and Metastasis of Colorectal Cancer (CRC) by Maintaining the Stability of Stromal Interaction Molecule 1 (STIM1) Proteins.
Silencing of Glucose-Regulated Protein 78 (GRP78) Enhances Cell Migration Through the Upregulation of Vimentin in Hepatocellular Carcinoma Cells.
Small-Animal PET Imaging of Pancreatic Cancer Xenografts Using a 64Cu-Labeled Monoclonal Antibody, MAb159.
SMR peptide antagonizes mortalin promoted release of extracellular vesicles and affects mortalin protection from complement-dependent cytotoxicity in breast cancer cells and leukemia cells.
Sodium Channel Subunit SCNN1B Suppresses Gastric Cancer Growth and Metastasis via GRP78 Degradation.
Solid-phase immunoassays in mechanism-based drug discovery: their application in the development of inhibitors of the molecular chaperone heat-shock protein 90.
Stress chaperone mortalin contributes to epithelial-mesenchymal transition and cancer metastasis.
Stress protein Hsp27 expression predicts the outcome in operated small cell lung carcinoma and large cell neuroendocrine carcinoma patients.
Survivin-Mediated Cancer Cell Migration Through GRP78 and Epithelial-Mesenchymal Transition (EMT) Marker Expression in Mahlavu Cells.
Targeting focal adhesion kinase with dominant-negative FRNK or Hsp90 inhibitor 17-DMAG suppresses tumor growth and metastasis of SiHa cervical xenografts.
Targeting heat shock protein 27 (HspB1) interferes with bone metastasis and tumour formation in vivo.
Targeting heat shock protein 90 for anti-cancer drug development.
Targeting Hsp90 in Non-Cancerous Maladies.
Targeting the Extracellular HSP90 Co-Chaperone Morgana Inhibits Cancer Cell Migration and Promotes Anticancer Immunity.
Targeting the molecular chaperone heat shock protein 90 (HSP90): Lessons learned and future directions.
Targeting the testis-specific heat-shock protein 70-2 (HSP70-2) reduces cellular growth, migration, and invasion in renal cell carcinoma cells.
The 4C5 cell-impermeable anti-HSP90 antibody with anti-cancer activity, is composed of a single light chain dimer.
The antitumor agent PBT-1 directly targets HSP90 and hnRNP A2/B1 and inhibits lung adenocarcinoma growth and metastasis.
The clinicopathological significance of Mortalin overexpression in invasive ductal carcinoma of breast.
The co-chaperone UNC45A is essential for the expression of mitotic kinase NEK7 and tumorigenesis.
The effects of Hsp90 expression alteration on spinal metastases of breast carcinoma.
The expression of HSP60 and HSP10 in large bowel carcinomas with lymph node metastase.
The heat shock protein 90 inhibitor, 17-allylamino-17-demethoxygeldanamycin, enhances osteoclast formation and potentiates bone metastasis of a human breast cancer cell line.
The hexameric structures of human heat shock protein 90.
The HIV Protease Inhibitor Nelfinavir Dowregulates RET Signaling and Induces Apoptosis in Medullary Thyroid Cancer Cells.
The matrix metalloproteinase 7 (MMP7) links Hsp90 chaperone with acquired drug resistance and tumor metastasis.
The phosphorylation-specific association of STMN1 with GRP78 promotes breast cancer metastasis.
The regulatory mechanism of Hsp90alpha secretion and its function in tumor malignancy.
The role of c-Src in the invasion and metastasis of hepatocellular carcinoma cells induced by association of cell surface GRP78 with activated ?2M.
Therapeutic potency of heat-shock protein-90 pharmacological inhibitors in the treatment of gastrointestinal cancer, current status and perspectives.
Tn antigen promotes human colorectal cancer metastasis via H-Ras mediated epithelial-mesenchymal transition activation.
Transactivation of the epidermal growth factor receptor by heat shock protein 90 via Toll-like receptor 4 contributes to the migration of glioblastoma cells.
Transcriptional repression of the prosurvival endoplasmic reticulum chaperone GRP78/BIP by E2F1.
Tumor suppressor HLJ1 binds and functionally alters nucleophosmin via activating enhancer binding protein 2alpha complex formation.
Tunicamycin promotes metastasis through upregulating endoplasmic reticulum stress induced GRP78 expression in thyroid carcinoma.
Up-regulation of cathepsin S expression by HSP90 and 5-HT7 receptor-dependent serotonin signaling correlates with triple negativity of human breast cancer.
Upregulated Heat Shock Proteins After Hyperthermic Chemotherapy Point to Induced Cell Survival Mechanisms in Affected Tumor Cells From Peritoneal Carcinomatosis.
Upregulation of Glucose-Regulated Protein 78 in Metastatic Cancer Cells Is Necessary for Lung Metastasis Progression.
[Association between expressions of HSP70, HSP90 and efficacy of chemotherapy in colorectal cancer patients with unresectable liver metastasis]
[Comparative proteomics of the serum in patients with nasopharyngeal carcinoma: a study with two-dimensional electrophoresis and MALDI-TOF-MS]
[Diagnostic and Therapeutic Potential of Membrane HSP90].
[Expression of GRP78 and GRP94 in the liver tissues and their clinicopathological significance in children with hepatoblastoma].
[The Role of Membrane-Bound Heat Shock Proteins Hsp90 in Migration of Tumor Cells in vitro and Involvement of Cell Surface Heparan Sulfate Proteoglycans in Protein Binding to Plasma Membrane].
Neoplasm Micrometastasis
Inhibition of Established Micrometastases by Targeted Drug Delivery via Cell Surface Associated GRP78.
Neoplasm, Residual
Combined PI3K/Akt and Hsp90 targeting synergistically suppresses essential functions of alloreactive T cells and increases Tregs.
GRP78 induction in cancer: therapeutic and prognostic implications.
Plasma Hsp90 Level as a Marker of Early Acute Lymphoblastic Leukemia Engraftment and Progression in Mice.
The unfolded protein response regulator GRP78/BiP as a novel target for increasing chemosensitivity in malignant gliomas.
Transcatheter arterial embolization combined with radiofrequency ablation activates CD8(+) T-cell infiltration surrounding residual tumors in the rabbit VX2 liver tumors.
Neoplasms
"UPRegulation" of CD47 by the endoplasmic reticulum stress pathway controls anti-tumor immune responses.
(-)- Epigallocatechin-3-gallate induces GRP78 accumulation in the ER and shifts mesothelioma constitutive UPR into proapoptotic ER stress.
(-)-epigallocatechin gallate overcomes resistance to Etoposide-induced cell death by targeting the molecular chaperone glucose-regulated protein 78.
(-)-Epigallocatechin gallate sensitizes breast cancer cells to paclitaxel in a murine model of breast carcinoma.
(1)H, (15)N and (13)C backbone resonance assignments of the TPR1 and TPR2A domains of mouse STI1.
(89)Zr-trastuzumab PET visualises HER2 downregulation by the HSP90 inhibitor NVP-AUY922 in a human tumour xenograft.
14-3-3sigma, the double-edged sword of human cancers.
17 AAG for HSP90 inhibition in cancer--from bench to bedside.
17-(Allylamino)-17-demethoxygeldanamycin activity in human melanoma models.
17-AAG and Apoptosis, Autophagy, and Mitophagy in Canine Osteosarcoma Cell Lines.
17-AAG inhibits vemurafenib-associated MAP kinase activation and is synergistic with cellular immunotherapy in a murine melanoma model.
17-AAG: mechanisms of antitumour activity.
17-ABAG, a novel geldanamycin derivative, inhibits LNCaP-cell proliferation through heat shock protein 90 inhibition.
17-Allyamino-17-demethoxygeldanamycin and 17-NN-dimethyl ethylene diamine-geldanamycin have cytotoxic activity against multiple gynecologic cancer cell types.
17-allylamino-17-demethoxygeldanamycin impeded chemotherapy through antioxidant activation via reducing reactive oxygen species-induced cell death.
17-Allylamino-17-demethoxygeldanamycin induces the degradation of androgen receptor and HER-2/neu and inhibits the growth of prostate cancer xenografts.
17-Allylamino-17-demethoxygeldanamycin-induced Changes in [(18)F]Fluorothymidine Uptake.
17-DMAG disrupted the autophagy flux leading to the apoptosis of acute lymphoblastic leukemia cells by inducing heat shock cognate protein 70.
17-DMAG induces heat shock protein 90 functional impairment in human bladder cancer cells: knocking down the hallmark traits of malignancy.
17-DMAG targets the NF-{kappa}B family of proteins to induce apoptosis in CLL: clinical implications of HSP90 inhibition.
177Lu-octreotate therapy for neuroendocrine tumours is enhanced by Hsp90 inhibition.
17AAG Treatment Accelerates Doxorubicin Induced Cellular Senescence: Hsp90 Interferes with Enforced Senescence of Tumor Cells.
18?-Glycyrrhetinic acid potentiates Hsp90 inhibition-induced apoptosis in human epithelial ovarian carcinoma cells via activation of death receptor and mitochondrial pathway.
1D Coordination Polymer Nanofibers for Low-Temperature Photothermal Therapy.
2,4-dihydroxy benzaldehyde derived Schiff bases as small molecule Hsp90 inhibitors: Rational identification of a new anticancer lead.
2-((1-Phenyl-1H-1,2,3-triazol-4-yl)methyl)-2-azabicyclo[3.2.1]octan-3-one derivatives: Simplification and modification of aconitine scaffold for the discovery of novel anticancer agents.
2-phenylethynesulfonamide inhibits growth of oral squamous cell carcinoma cells by blocking the function of heat shock protein 70.
27-Hydroxycholesterol is a specific factor in the neoplastic microenvironment of HCC that causes MDR via GRP75 regulation of the redox balance and metabolic reprogramming.
2D-PAGE of ovarian cancer: analysis of soluble and insoluble fractions using medium-range immobilized pH gradients.
3-Arylcoumarin derivatives manifest anti-proliferative activity through Hsp90 inhibition.
3D-QSAR Assisted Design, Synthesis and Evaluation of Novobiocin Analogues.
3D-QSAR, molecular docking, and molecular dynamic simulations for prediction of new Hsp90 inhibitors based on isoxazole scaffold.
4,5-diarylisoxazole Hsp90 chaperone inhibitors: potential therapeutic agents for the treatment of cancer.
5'-N-ethylcarboxamidoadenosine is not a paralog-specific Hsp90 inhibitor.
70-kDa heat shock cognate protein interacts directly with the N-terminal region of the retinoblastoma gene product pRb. Identification of a novel region of pRb-mediating protein interaction.
7Hsp70 serum levels in pet dogs-a potential diagnostic biomarker for spontaneous round cell tumors.
89Zr-bevacizumab PET of early antiangiogenic tumor response to treatment with HSP90 inhibitor NVP-AUY922.
90-kDa heat shock protein inhibition abrogates the topoisomerase I poison-induced G2/M checkpoint in p53-null tumor cells by depleting Chk1 and Wee1.
?-hCG induced mutant BRCA1 ignites drug resistance in susceptible breast tissue.
?-Lapachone Induces NQO1- and Oxidative Stress-Dependent Hsp90 Cleavage and Inhibits Tumor Growth and Angiogenesis.
?7 helix region of ?I domain is crucial for integrin binding to endoplasmic reticulum chaperone gp96: a potential therapeutic target for cancer metastasis.
?B-Crystallin in clear cell renal cell carcinoma: Tumor progression and prognostic significance.
?B-Crystallin is a Novel Oncoprotein Associated with Poor Prognosis in Breast Cancer.
?B-Crystallin regulates expansion of CD11b?Gr-1? immature myeloid cells during tumor progression.
?B-crystallin: a novel regulator of breast cancer metastasis to the brain.
?III-Tubulin alters glucose metabolism and stress response signaling to promote cell survival and proliferation in glucose-starved non-small cell lung cancer cells.
A 12-mer Peptide of Tag7 (PGLYRP1) Forms a Cytotoxic Complex with Hsp70 and Inhibits TNF-Alpha Induced Cell Death.
A 14-mer Hsp70 peptide stimulates natural killer (NK) cell activity.
A 14-mer peptide from HSP70 protein is the critical epitope which enhances NK activity against tumor cells in vivo.
A 2,5-Dihydroxybenzoic Acid-Gelatin Conjugate Inhibits the Basal and Hsp90-Stimulated Migration and Invasion of Tumor Cells.
A 2-helix small protein labeled with 68Ga for PET imaging of HER2 expression.
A bifunctional organometallic ruthenium drug with multiple modes of inducing apoptosis.
A biochemical rationale for the anticancer effects of Hsp90 inhibitors: slow, tight binding inhibition by geldanamycin and its analogues.
A carcinogenic trigger to study the function of tumor suppressor genes in Schmidtea mediterranea.
A case of progressing focal nodular hyperplasia and its molecular expression pattern.
A cell-penetrating peptidic GRP78 ligand for tumor cell-specific prodrug therapy.
A chemical compound inhibiting the Aha1-Hsp90 chaperone complex.
A chemical proteomics approach reveals Hsp27 as a target for proapoptotic clerodane diterpenes.
A compound that inhibits the HOP-Hsp90 complex formation and has unique killing effects in breast cancer cell lines.
A computational study on the role of water and conformational fluctuations in Hsp90 in response to inhibitors.
A CpG oligodeoxynucleotide potentiates the anti-tumor effect of HSP65-Her2 fusion protein against Her2 positive B16 melanoma in mice.
A cremophor-free formulation for tanespimycin (17-AAG) using PEO-b-PDLLA micelles: Characterization and pharmacokinetics in rats.
A Critical Role for GRP78/BiP in the Tumor Microenvironment for Neovascularization during Tumor Growth and Metastasis.
A critical role for HSP90 in cancer cell invasion involves interaction with the extracellular domain of HER-2.
A cytosolic heat shock protein 90 and cochaperone CDC37 complex is required for RIP3 activation during necroptosis.
A DM1-doped porous gold nanoshell system for NIR accelerated redox-responsive release and triple modal imaging guided photothermal synergistic chemotherapy.
A Dynamic molecular basis for malfunction in disease mutants of p97/VCP.
A first in human, safety, pharmacokinetics, and clinical activity phase I study of once weekly administration of the Hsp90 inhibitor ganetespib (STA-9090) in patients with solid malignancies.
A Fluorescent Hsp90 Probe Demonstrates the Unique Association between Extracellular Hsp90 and Malignancy in Vivo.
A fragment-based approach applied to a highly flexible target: Insights and challenges towards the inhibition of HSP70 isoforms.
A group of novel HIF-1? inhibitors, glyceollins, blocks HIF-1? synthesis and decreases its stability via inhibition of the PI3K/AKT/mTOR pathway and Hsp90 binding.
A heat shock protein 70-based vaccine with enhanced immunogenicity for clinical use.
A high throughput substrate binding assay reveals hexachlorophene as an inhibitor of the ER-resident HSP70 chaperone GRP78.
A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors.
A High-Throughput Screen for Inhibitors of the Hsp90-Chaperone Machine.
A highly selective Hsp90 affinity chromatography resin with a cleavable linker.
A Homogeneous Polysaccharide from Fructus Schisandra chinensis (Turz.) Baill Induces Mitochondrial Apoptosis through the Hsp90/AKT Signalling Pathway in HepG2 Cells.
A hsp70-2 mutation recognized by CTL on a human renal cell carcinoma.
A hypoxia-induced decrease of either MICA/B or Hsp70 on the membrane of tumor cells mediates immune escape from NK cells.
A large animal model to evaluate the effects of Hsp90 inhibitors for the treatment of lung adenocarcinoma.
A Mortalin/HSPA9-Mediated Switch in Tumor-Suppressive Signaling of Raf/MEK/Extracellular Signal-Regulated Kinase.
A multicenter phase II study of ganetespib monotherapy in patients with genotypically defined advanced non-small cell lung cancer.
A multimodal imaging-guided nanoreactor for cooperative combination of tumor starvation and multiple mechanism-enhanced mild temperature phototherapy.
A murine monoclonal antibody directed against the carboxyl-terminal domain of GRP78 suppresses melanoma growth in mice.
A new approach for enhancing differential selectivity of drugs to cancer cells.
A new purification method for enhancing the immunogenicity of heat shock protein 70-peptide complexes.
A new role of GRP75-USP1-SIX1 protein complex in driving prostate cancer progression and castration resistance.
A new tumor suppressor DnaJ-like heat shock protein, HLJ1, and survival of patients with non-small-cell lung carcinoma.
A new tumor-specific variant of GRP78 as target for antibody-based therapy.
A non-receptor-mediated mechanism for internalization of molecular chaperones.
A novel anticancer approach: SEA-anchored tumor cells expressing heat shock protein 70 onto the surface elicit strong anticancer efficacy.
A Novel Approach to Anticancer Therapy: Molecular Modules Based on the Barnase:Barstar Pair for Targeted Delivery of HSP70 to Tumor Cells.
A novel C-terminal HSP90 inhibitor KU135 induces apoptosis and cell cycle arrest in melanoma cells.
A novel C-terminal Hsp90 inhibitor KU758 synergizes efficacy in combination with BRAF or MEK inhibitors and targets drug-resistant pathways in BRAF-mutant melanomas.
A Novel Class of Hsp90 C-Terminal Modulators Have Pre-Clinical Efficacy in Prostate Tumor Cells Without Induction of a Heat Shock Response.
A novel class of specific Hsp90 small molecule inhibitors demonstrate in vitro and in vivo anti-tumor activity in human melanoma cells.
A novel combination treatment for breast cancer cells involving BAPTA-AM and proteasome inhibitor bortezomib.
A novel derivative of the natural agent deguelin for cancer chemoprevention and therapy.
A Novel Doxorubicin Prodrug with GRP78 Recognition and Nucleus-Targeting Ability for Safe and Effective Cancer Therapy.
A Novel Extracellular Hsp90 Mediated Co-Receptor Function for LRP1 Regulates EphA2 Dependent Glioblastoma Cell Invasion.
A novel heat shock protein 90 inhibitor potently targets adrenocortical carcinoma tumor suppression.
A novel Hsp90 inhibitor AT13387 induces senescence in EBV-positive nasopharyngeal carcinoma cells and suppresses tumor formation.
A novel HSP90 inhibitor with reduced hepatotoxicity synergizes with radiotherapy to induce apoptosis, abrogate clonogenic survival, and improve tumor control in models of colorectal cancer.
A novel method to assay molecular chaperone activity of HSP70: evaluation of drug resistance in cancer treatment.
A novel method to identify and characterise peptide mimotopes of heat shock protein 70-associated antigens.
A novel sulfamethoxazole derivative as an inhibitory agent against HSP70: A combination of computational with in vitro studies.
A novel temperature-responsive micelle for enhancing combination therapy.
A novel therapeutic strategy for the treatment of glioma, combining chemical and molecular targeting of hsp90a.
A novel, small molecule inhibitor of Hsc70/Hsp70 potentiates Hsp90 inhibitor induced apoptosis in HCT116 colon carcinoma cells.
A peptidic unconjugated GRP78/BiP ligand modulates the unfolded protein response and induces prostate cancer cell death.
A Phase 1 Dose-Escalation Study of Irinotecan in Combination with 17-Allylamino-17-Demethoxygeldanamycin in Patients with Solid Tumors.
A phase 1 study of the heat shock protein 90 inhibitor retaspimycin hydrochloride (IPI-504) in patients with gastrointestinal stromal tumors or soft tissue sarcomas.
A phase 2 clinical trial of the heat shock protein 90 (HSP 90) inhibitor ganetespib in patients with refractory advanced esophagogastric cancer.
A Phase 2 Study of the Hsp90 Inhibitor AUY922 as Treatment for Patients with Refractory Gastrointestinal Stromal Tumors.
A phase I dose-escalation study of apatorsen (OGX-427), an antisense inhibitor targeting heat shock protein 27 (Hsp27), in patients with castration-resistant prostate cancer and other advanced cancers.
A phase I study of PF-04929113 (SNX-5422), an orally bioavailable heat shock protein 90 inhibitor, in patients with refractory solid tumor malignancies and lymphomas.
A Phase I Study of the Heat Shock Protein 90 Inhibitor Alvespimycin (17-DMAG) Given Intravenously to Patients with Advanced Solid Tumors.
A Phase I Study of the Hsp90 Inhibitor AUY922 plus Capecitabine for the Treatment of Patients with Advanced Solid Tumors.
A phase I trial of intratumoral administration of recombinant oncolytic adenovirus overexpressing HSP70 in advanced solid tumor patients.
A phase I trial of vorinostat and bortezomib in children with refractory or recurrent solid tumors: A Children's Oncology Group phase I consortium study (ADVL0916).
A phase I-II study of the histone deacetylase inhibitor vorinostat plus sequential weekly paclitaxel and doxorubicin-cyclophosphamide in locally advanced breast cancer.
A Phase II Study of Ganetespib as Second-line or Third-line Therapy for Metastatic Pancreatic Cancer.
A phase II study of gemcitabine in combination with tanespimycin in advanced epithelial ovarian and primary peritoneal carcinoma.
A phase II study of Hsp-7 (SGN-00101) in women with high-grade cervical intraepithelial neoplasia.
A phase II trial of ganetespib, a heat shock protein 90 Hsp90) inhibitor, in patients with docetaxel-pretreated metastatic castrate-resistant prostate cancer (CRPC)-a prostate cancer clinical trials consortium (PCCTC) study.
A Physiologically-Based Pharmacokinetic Model of Alvespimycin in Mice and Extrapolation to Rats and Humans.
A pivotal role for heat shock protein 90 in Ewing sarcoma resistance to anti-insulin-like growth factor 1 receptor treatment: in vitro and in vivo study.
A positive feedback loop between GRP78 and VPS34 is critical for GRP78-mediated autophagy in cancer cells.
A Preliminary Study on RCN3 Protein Expression in Non-small Cell Lung Cancer.
A prescription for 'stress' - the role of Hsp90 in genome stability and cellular adaptation.
A profile of differentially expressed genes in primary colorectal cancer using suppression subtractive hybridization.
A proteomic approach towards the Hsp90-dependent ubiquitinylated proteome.
A proteomic study of the differential protein expression in MDBK cells after bovine herpesvirus type 1 infection (BHV-1) strain treatment.
A pyrrole-based natural small molecule mitigates HSP90 expression in MDA-MB-231 cells and inhibits tumor angiogenesis in mice by inactivating HSF-1.
A randomized, placebo-controlled study of the effects of the p38 MAPK inhibitor SB-681323 on blood biomarkers of inflammation in COPD patients.
A repurposing strategy for Hsp90 inhibitors demonstrates their potency against filarial nematodes.
A review of recent patents on the protozoan parasite HSP90 as a drug target.
A role for HMGB1, HSP60 and Myd88 in growth of murine mammary carcinoma in vitro.
A role of Rab7 in stabilizing EGFR-Her2 and in sustaining Akt survival signal.
A Scaffold Merging Approach to Hsp90 C-terminal Inhibition: Synthesis and Evaluation of a Chimeric Library.
A secreted Heat shock protein 90 of Trichomonas vaginalis.
A selenosemicarbazone complex with copper efficiently down-regulates the 90-kDa heat shock protein HSP90AA1 and its client proteins in cancer cells.
A signal peptide derived from Hsp60 induces protective cytotoxic T lymphocyte immunity against lymphoid malignancies independently of TAP and classical MHC-I.
A simple yeast-based system for analyzing inhibitor resistance in the human cancer drug targets Hsp90alpha/beta.
A small molecule cell-impermeant Hsp90 antagonist inhibits tumor cell motility and invasion.
A small molecule designed to bind to the adenine nucleotide pocket of Hsp90 causes Her2 degradation and the growth arrest and differentiation of breast cancer cells.
A small molecule inhibitor of inducible heat shock protein 70.
A structure-guided molecular chaperone approach for restoring the transcriptional activity of the p53 cancer mutant Y220C.
A Targetable Molecular Chaperone Hsp27 Confers Aggressiveness in Hepatocellular Carcinoma.
A three-dimensional tumor cell defect in activating autologous CTLs is associated with inefficient antigen presentation correlated with heat shock protein-70 down-regulation.
A time-resolved fluorescence resonance energy transfer-based HTS assay and a surface plasmon resonance-based binding assay for heat shock protein 90 inhibitors.
A trial of SGN-00101 (HspE7) to treat high-grade anal intraepithelial neoplasia in HIV-positive individuals.
A triazine compound S06 inhibits proinvasive crosstalk between carcinoma cells and stromal fibroblasts via binding to heat shock protein 90.
A tumor-targeted Ganetespib-zinc phthalocyanine conjugate for synergistic chemo-photodynamic therapy.
A unique role for heat shock protein 70 and its binding partner tissue transglutaminase in cancer cell migration.
AAA+ ATPases Reptin and Pontin as potential diagnostic and prognostic biomarkers in salivary gland cancer - a short report.
Aberrant expression of stress-induced phosphoprotein 1 in colorectal cancer and its clinicopathologic significance.
Ablation of elongation factor 2 kinase enhances heat-shock protein 90 chaperone expression and protects cells under proteotoxic stress.
Abnormal cell cycle regulation in primary human uveal melanoma cultures.
Absence of caveolin-1 alters heat shock protein expression in spontaneous mammary tumors driven by Her-2/neu expression.
Abundance of heat shock proteins (hsp89, hsp60, and hsp27) in malignant cells of Hodgkin's disease.
Accelerated, but not conventional, radiotherapy of murine B-cell lymphoma induces potent T cell-mediated remissions.
Acetylation modification regulates GRP78 secretion in colon cancer cells.
Acetylation-dependent regulation of TPD52 isoform 1 modulates chaperone-mediated autophagy in prostate cancer.
Acidic stress facilitates tyrosine phosphorylation of HLJ1 to associate with actin cytoskeleton in lung cancer cells.
Acidosis acts through HSP90 in a PHD/VHL-independent manner to promote HIF function and stem cell maintenance in glioma.
Acquired resistance to 5-fluorouracil via HSP90/Src-mediated increase in thymidylate synthase expression in colon cancer.
Acquired resistance to HSP90 inhibitor 17-AAG and increased metastatic potential are associated with MUC1 expression in colon carcinoma cells.
Activated ?2-macroglobulin binding to cell surface GRP78 induces trophoblastic cell fusion.
Activated ?2-Macroglobulin Regulates Transcriptional Activation of c-Myc Target Genes Through Cell Surface GRP78.
Activating transcription factor-3 (ATF3) functions as a tumor suppressor in colon cancer and is up-regulated upon heat-shock protein 90 (Hsp90) inhibition.
Activation and clinical significance of the unfolded protein response in breast cancer.
Activation of Hsp90 Enzymatic Activity and Conformational Dynamics through Rationally Designed Allosteric Ligands.
Activation of mitochondrial unfolded protein response is associated with Her2-overexpression breast cancer.
Activation of MYC, a bona fide client of HSP90, contributes to intrinsic ibrutinib resistance in mantle cell lymphoma.
Activation of the ATF6, XBP1 and grp78 genes in human hepatocellular carcinoma: a possible involvement of the ER stress pathway in hepatocarcinogenesis.
Activation of wild type p53 function by its mortalin-binding, cytoplasmically localizing carboxyl terminus peptides.
Active-specific immunotherapy of human cancers with the heat shock protein Gp96-revisited.
Activity of dasatinib, a dual SRC/ABL kinase inhibitor, and IPI-504, a heat shock protein 90 inhibitor, against gastrointestinal stromal tumor-associated PDGFRAD842V mutation.
Activity of the heat shock protein 90 inhibitor ganetespib in melanoma.
Acute cadmium exposure enhances AP-1 DNA binding and induces cytokines expression and heat shock protein 70 in HepG2 cells.
Adapted ATPase domain communication overcomes the cytotoxicity of p97 inhibitors.
Additive viability-loss following hsp70/hsc70 double interference and Hsp90 inhibition in two breast cancer cell lines.
Adeno-associated virus mediated gene transfer of Shepherdin inhibits gallbladder carcinoma growth in vitro and in vivo.
Adenomatous polyposis coli mutants dominantly activate Hsf1-dependent cell stress pathways through inhibition of microtubule dynamics.
Adenosine-derived inhibitors of 78 kDa glucose regulated protein (Grp78) ATPase: insights into isoform selectivity.
Adenovirus E1A, not human papillomavirus E7, sensitizes tumor cells to lysis by macrophages through nitric oxide- and TNF-alpha-dependent mechanisms despite up-regulation of 70-kDa heat shock protein.
ADP-ribosylation inhibitors inhibit cellular RNA synthesis but do not affect expression of manganous superoxide dismutase or heat shock protein 70 in tumor necrosis factor alpha-sensitive and -resistant tumor cells.
Advances in HSP27 and HSP90-targeting strategies for glioblastoma.
Advances in the clinical development of heat shock protein 90 (Hsp90) inhibitors in cancers.
Advances in the discovery and development of heat-shock protein 90 inhibitors for cancer treatment.
Affinity purification probes of potential use to investigate the endogenous Hsp70 interactome in cancer.
Aggregatibacter actinomycetemcomitans accelerates atherosclerosis with an increase in atherogenic factors in spontaneously hyperlipidemic mice.
AIDing cancer treatment: Reducing AID activity via HSP90 inhibition.
Ailanthone targets p23 to overcome MDV3100 resistance in castration-resistant prostate cancer.
Ajuba receptor mediates the internalization of tumor-secreted GRP78 into macrophages through different endocytosis pathways.
AKT inhibition mitigates GRP78 (glucose-regulated protein) expression and contribution to chemoresistance in endometrial cancers.
Akt shows variable sensitivity to an Hsp90 inhibitor depending on cell context.
Alanyl?glutamine prophylactically protects against lipopolysaccharide?induced acute lung injury by enhancing the expression of HSP70.
ALK inhibitors in non-small cell lung cancer: crizotinib and beyond.
Alleviating neurodegeneration by an anticancer agent: an Hsp90 inhibitor (17-AAG).
Alleviative effect of selenium on inflammatory damage caused by lead via inhibiting inflammatory factors and heat shock proteins in chicken testes.
Allosteric regulation of the thermostability and DNA binding activity of human p53 by specific interacting proteins. CRC Cell Transformation Group.
Alpha B crystallin expression in response to hormone, oncogenes and stress.
AlphaB-crystallin is a novel oncoprotein that predicts poor clinical outcome in breast cancer.
AlphaB-crystallin: a novel marker of invasive basal-like and metaplastic breast carcinomas.
Alterations in trace element levels and mRNA expression of Hsps and inflammatory cytokines in livers of duck exposed to molybdenum or/and cadmium.
Alterations of the Hsp70/Hsp90 chaperone and the HOP/CHIP co-chaperone system in cancer.
Altered Hsp90 function in cancer: a unique therapeutic opportunity.
Altered molecular pathways decides the treatment outcome of Hsp90 inhibitors against breast cancer cells.
Altered states: selectively drugging the Hsp90 cancer chaperone.
Alternate Strategies of Hsp90 Modulation for the Treatment of Cancer and Other Diseases.
Alternative approaches to Hsp90 modulation for the treatment of cancer.
Alternative mechanism by which IFN-gamma enhances tumor recognition: active release of heat shock protein 72.
Amelioration of renal ischaemia-reperfusion injury by liposomal delivery of curcumin to renal tubular epithelial and antigen presenting cells.
Ameliorative effect of vitamin E on hepatic oxidative stress and hypoimmunity induced by high-fat diet in turbot (Scophthalmus maximus).
An immunodominant MHC class II-restricted tumor antigen is conformation dependent and binds to the endoplasmic reticulum chaperone, calreticulin.
An Impermeant Ganetespib Analog Inhibits Extracellular Hsp90-Mediated Cancer Cell Migration that Involves Lysyl Oxidase 2-like Protein.
An improved route to 19-substituted geldanamycins as novel Hsp90 inhibitors - potential therapeutics in cancer and neurodegeneration.
An investigation into the potential use of serum Hsp70 as a novel tumour biomarker for Hsp90 inhibitors.
An updated patent review of anticancer Hsp90 inhibitors (2013-present).
Analogs of the Allosteric Heat Shock Protein 70 (Hsp70) Inhibitor, MKT-077, as Anti-Cancer Agents.
Analysis of 8-hydroxyguanine in rat kidney genomic DNA after administration of a renal carcinogen, ferric nitrilotriacetate.
Analysis of conformational determinants underlying HSP90-kinase interaction.
Analysis of differently expressed proteins involved in metastatic niche of lung.
Analysis of expression of heat shock protein-90 (HSP90) and the effects of HSP90 inhibitor (17-AAG) in multiple myeloma.
Analysis of gene and protein expression of cytochrome P450 and stress-associated molecules in rat liver after spaceflight.
Analysis of heat shock proteins and cytokines expressed during early stages of osteoarthritis in a mouse model.
Analysis of Hsp90 allosteric modulators interactome reveals a potential dual action mode involving mitochondrial MDH2.
Analysis of HSP90 Expression Is Valuable in the Differential Diagnosis of Ocular Surface Squamous Lesions.
Analysis of MHC genes in a Tunisian isolate with autoimmune thyroid diseases: implication of TNF -308 gene polymorphism.
Analysis of polypeptide expression in benign and malignant human breast lesions.
ANCCA/ATAD2 Overexpression Identifies Breast Cancer Patients with Poor Prognosis, Acting to Drive Proliferation and Survival of Triple-Negative Cells through Control of B-Myb and EZH2.
Androgen receptor (AR) expression is an independent unfavorable prognostic factor in gastric cancer.
Androgen receptor and heat shock protein 27 co-regulate the malignant potential of molecular apocrine breast cancer.
Androgen receptor signaling in hepatocellular carcinoma and pancreatic cancers.
Andrographolide and its analogues: versatile bioactive molecules for combating inflammation and cancer.
Andrographolide downregulates the v-Src and Bcr-Abl oncoproteins and induces Hsp90 cleavage in the ROS-dependent suppression of cancer malignancy.
Andrographolide-induced apoptosis in human renal tubular epithelial cells: Roles of endoplasmic reticulum stress and inflammatory response.
Anesthesia for euthanasia influences mRNA expression in healthy mice and after traumatic brain injury.
Aneuploidy and proteotoxic stress in cancer.
Ansamycin Inhibitors of Hsp90: Nature's Prototype for Anti-Chaperone Therapy.
Anti-breast tumor activity of Eclipta extract in-vitro and in-vivo: novel evidence of endoplasmic reticulum specific localization of Hsp60 during apoptosis.
Anti-cancer therapeutic approaches based on intracellular and extracellular heat shock proteins.
Anti-citrullinated peptide antibodies bind surface-expressed citrullinated GRP78 on monocytes/macrophages stimulate tumor necrosis factor-alpha production.
Anti-GRP78 autoantibodies induce endothelial cell activation and accelerate the development of atherosclerotic lesions.
Anti-HSP auto-antibodies enhance HSP-induced pro-inflammatory cytokine production in human monocytic cells via Toll-like receptors.
Anti-inflammatory Potential of Petiveria alliacea on Activated RAW264.7 Murine Macrophages.
Anti-intoxication and protective effects of a recombinant serine protease inhibitor from Lentinula edodes against acute alcohol-induced liver injury in mice.
Anti-KDEL-coated nanoparticles: A promising tumor targeting approach for ovarian cancer?
Anti-malaria drug blocks proteotoxic stress response: anti-cancer implications.
Anti-myeloma activity of the novel 2-aminothienopyrimidine Hsp90 inhibitor NVP-BEP800.
Anti-NSCLC activity in vitro of Hsp90N inhibitor KW-2478 and complex crystal structure determination of Hsp90N-KW-2478.
Anti-tumor activity of the HSP90 inhibitor SNX-2112 in pediatric cancer cell lines.
Anti-tumor immune responses following neoadjuvant immunotherapy with a recombinant adenovirus expressing HSP72 to rodent tumors.
Antiangiogenic effects of a novel synthetic curcumin analogue in pancreatic cancer.
Antibody Targeting GRP78 Enhances the Efficacy of Radiation Therapy in Human Glioblastoma and Non-Small Cell Lung Cancer Cell Lines and Tumor Models.
Anticancer Activity in Honeybee Propolis: Functional Insights to the Role of Caffeic Acid Phenethyl Ester and Its Complex With ?-Cyclodextrin.
Anticancer activity of Celastrol in combination with ErbB2-targeted therapeutics for treatment of ErbB2-overexpressing breast cancers.
Anticancer activity of methylene blue via inhibition of heat shock protein 70.
Anticancer drugs up-regulate HspBP1 and thereby antagonize the prosurvival function of Hsp70 in tumor cells.
Anticancer effects of ginsenoside Rg1, cinnamic acid, and tanshinone IIA in osteosarcoma MG-63 cells: nuclear matrix downregulation and cytoplasmic trafficking of nucleophosmin.
Antileukemic activity of shepherdin and molecular diversity of hsp90 inhibitors.
Antileukemic activity of the HSP70 inhibitor pifithrin-? in acute leukemia.
Antimelanoma activity of apoptogenic carbonyl scavengers.
Antimyeloma activity of heat shock protein-90 inhibition.
Antiproliferative and apoptotic activities of tosylcyclonovobiocic acids as potent heat shock protein 90 inhibitors in human cancer cells.
Antiproliferative effect of p-Coumaric acid targets UPR activation by downregulating Grp78 in colon cancer.
Antiproliferative effect of the HSP90 inhibitor NVP-AUY922 is determined by the expression of PTEN in esophageal cancer.
Antiproliferative Effects of Thymoquinone in MCF-7 Breast and HepG2 Liver Cancer Cells: Possible Role of Ceramide and ER Stress.
Antitumor activity and molecular effects of the novel heat shock protein 90 inhibitor, IPI-504, in pancreatic cancer.
Antitumor activity of efrapeptins, alone or in combination with 2-deoxyglucose, in breast cancer in vitro and in vivo.
Antitumor activity of mHSP65-TTL enhanced by administration of low dose cyclophosphamide in pancreatic cancer-bearing mice.
Antitumor activity of NVP-AUY922, a novel heat shock protein 90 inhibitor, in human gastric cancer cells is mediated through proteasomal degradation of client proteins.
Antitumor activity of SNX-2112, a synthetic heat shock protein-90 inhibitor, in MET-amplified tumor cells with or without resistance to selective MET Inhibition.
Antitumor activity of the combination of an HSP90 inhibitor and a PI3K/mTOR dual inhibitor against cholangiocarcinoma.
Antitumor effect of novel HSP90 inhibitor NVP-AUY922 against oral squamous cell carcinoma.
Antitumor effect of reduction of 150-kDa oxygen-regulated protein expression on human prostate cancer cells.
Antitumor Effects and the Compatibility Mechanisms of Herb Pair Scleromitrion diffusum (Willd.) R. J. Wang-Sculellaria barbata D. Don.
Antitumor efficacy of IPI-504, a selective heat shock protein 90 inhibitor against human epidermal growth factor receptor 2-positive human xenograft models as a single agent and in combination with trastuzumab or lapatinib.
Apoptosis of osteosarcoma cultures by the combination of the cyclin-dependent kinase inhibitor SCH727965 and a heat shock protein 90 inhibitor.
Application of differential display, with in situ hybridization verification, to microscopic samples of breast cancer tissue.
Application of docking-based comparative intermolecular contacts analysis to validate Hsp90? docking studies and subsequent in silico screening for inhibitors.
Approaches for defining the Hsp90-dependent proteome.
Aptamer-Peptide Conjugates as Targeted Chemosensitizers for Breast Cancer Treatment.
Aqueous Terminalia arjuna extract modulates expression of key atherosclerosis-related proteins in a hypercholesterolemic rabbit: A proteomic-based study.
Are IgG antibodies to heat shock proteins HSP27 and HSP60 useful markers in endometrial cancer and cervical cancer?
Areca nut contributes to oral malignancy through facilitating the conversion of cancer stem cells.
Arginine-Arginine-Leucine Peptide Targeting Heat Shock Protein 70 for Cancer Imaging.
Arsenic trioxide exerts antimyeloma effects by inhibiting activity in the cytoplasmic substrates of histone deacetylase 6.
Arsenic trioxide reactivates proteasome-dependent degradation of mutant p53 protein in cancer cells in part via enhanced expression of Pirh2 E3 ligase.
Arsenic-induced testicular toxicity in Gallus gallus: Expressions of inflammatory cytokines and heat shock proteins.
Assay design and development strategies for finding Hsp90 inhibitors and their role in human diseases.
Assay strategies for the discovery and validation of therapeutics targeting Brugia pahangi Hsp90.
Assays for Identification of Hsp90 Inhibitors and Biochemical Methods for Discriminating their Mechanism of Action.
Assessing the chemical diversity of an hsp90 database.
Assessing the Impact of HER2 Status on the Antitumor Activity of an HSP90 Inhibitor in Human Tumor Xenograft Mice using Pharmacokinetics-Pharmacodynamic Modeling.
Assisting anti-PD-1 antibody treatment with a liposomal system capable of recruiting immune cells.
Association between Alpha B-crystallin expression and prognosis in patients with solid tumors: A protocol for systematic review and meta-analysis.
Association between heat shock protein 70 gene polymorphisms and clinical outcomes in intensive care unit patients with sepsis.
Association between the unfolded protein response, induced by 2-deoxyglucose, and hypersensitivity to cisplatin: a mechanistic study employing molecular genomics.
Association between vaginal 70-kd heat shock protein, interleukin-1 receptor antagonist, and microbial flora in mid trimester pregnant women.
Association of Alpha B-Crystallin Expression with Tumor Differentiation Grade in Colorectal Cancer Patients.
Association of elevated GRP78 expression with increased astrocytoma malignancy via Akt and ERK pathways.
Association of elevated GRP78 expression with increased lymph node metastasis and poor prognosis in patients with gastric cancer.
Association of hsp90 to the hTERT promoter is necessary for hTERT expression in human oral cancer cells.
Association of mortalin (HSPA9) with liver cancer metastasis and prediction for early tumor recurrence.
Association of nuclear-localized Nemo-like kinase with heat-shock protein 27 inhibits apoptosis in human breast cancer cells.
Association of tapasin and HLA class I antigen down-regulation in primary maxillary sinus squamous cell carcinoma lesions with reduced survival of patients.
Associations between the Nrf2/Keap1 pathway and mitochondrial functions in colorectal cancer are affected by metastasis.
Associations of HSP90 client proteins in human breast cancer.
Asymmetric Hsp90 N domain SUMOylation recruits Aha1 and ATP-competitive inhibitors.
AT-533, a novel Hsp90 inhibitor, inhibits breast cancer growth and HIF-1?/VEGF/VEGFR-2-mediated angiogenesis in vitro and in vivo.
ATAD3A stabilizes GRP78 to suppress ER stress for acquired chemoresistance in colorectal cancer.
ATP-competitive inhibitors block protein kinase recruitment to the Hsp90-Cdc37 system.
Attenuated phosphorylation of heat shock protein 27 correlates with tumor progression in patients with hepatocellular carcinoma.
Attenuating effects of coenzyme Q10 and amlodipine in ulcerative colitis model in rats.
Augmentation of antitumor immunity by fusions of ethanol-treated tumor cells and dendritic cells stimulated via dual TLRs through TGF-?1 blockade and IL-12p70 production.
Augmentation of immune cell activity against tumor cells by Rauwolfia radix.
Author Correction: Cancer cell responses to Hsp70 inhibitor JG-98: Comparison with Hsp90 inhibitors and finding synergistic drug combinations.
Autoantibodies against cell surface GRP78 promote tumor growth in a murine model of melanoma.
Autoantibodies against the cell surface-associated chaperone GRP78 stimulate tumor growth via tissue factor.
Autoantibody to heat shock protein Hsp40 in sera of lung cancer patients.
Autoimmunity in chronic active Helicobacter hepatitis of mice. Serum antibodies and expression of heat shock protein 70 in liver.
Autologous Hsp70 induces antigen specific Th1 immune responses in a murine T-cell lymphoma.
Autophagy gene fingerprint in human ischemia and reperfusion.
Autophagy in the physiological endometrium and cancer.
Autoreactive T cells from normal mice recognize mycobacterial 65 kd heat-shock protein from Mycobacterium bovis.
AUY922 induces retinal toxicity through attenuating TRPM1.
Bacterial heat shock proteins directly induce cytokine mRNA and interleukin-1 secretion in macrophage cultures.
Bacterial production and functional characterization of the Fab fragment of the murine IgG1/lambda monoclonal antibody cmHsp70.1, a reagent for tumour diagnostics.
BAG-1/SODD, HSP70 and HSP90 are potential prognostic markers of poor survival in node-negative breast carcinoma.
BAG-1: a multifunctional regulator of cell growth and survival.
Bag-3 expression is involved in pathogenesis and progression of colorectal carcinomas.
BAG-i expression in human breast cancer: interrelationship between BAG-1 RNA, protein, HSC70 expression and clinico-pathological data.
BAG3 controls angiogenesis through regulation of ERK phosphorylation.
BAG3 directly associates with guanine nucleotide exchange factor of Rap1, PDZGEF2, and regulates cell adhesion.
BAG3 Protein Is Involved in Endothelial Cell Response to Phenethyl Isothiocyanate.
BAG3 sensitizes cancer cells exposed to DNA damaging agents via direct interaction with GRP78.
Bcl-2 regulates HIF-1alpha protein stabilization in hypoxic melanoma cells via the molecular chaperone HSP90.
BDNF, TNF?, HSP90, CFH, and IL-10 Serum Levels in Patients with Early or Late Onset Alzheimer's Disease or Mild Cognitive Impairment.
Beneficial effects of dietary ?-glucan on growth and health status of Pacific white shrimp Litopenaeus vannamei at low salinity.
Benfotiamine Attenuates Inflammatory Response in LPS Stimulated BV-2 Microglia.
Benzoquinone ansamycin heat shock protein 90 inhibitors modulate multiple functions required for tumor angiogenesis.
Berberine-induced autophagic cell death by elevating GRP78 levels in cancer cells.
Betulinic Acid Suppresses Breast Cancer Metastasis by Targeting GRP78-Mediated Glycolysis and ER Stress Apoptotic Pathway.
Beyond the endoplasmic reticulum: atypical GRP78 in cell viability, signalling and therapeutic targeting.
Bi2 S3 -Tween 20 Nanodots Loading PI3K Inhibitor, LY294002, for Mild Photothermal Therapy of LoVo Cells In Vitro and In Vivo.
BIIB021, a novel Hsp90 inhibitor, sensitizes esophageal squamous cell carcinoma to radiation.
BIIB021, a novel HSP90 inhibitor, sensitizes head and neck squamous cell carcinoma to radiotherapy.
BIIB021, a synthetic HSP90 inhibitor, has broad application against tumors with acquired multidrug resistance.
BIIB021, an Hsp90 inhibitor, effectively kills a myelodysplastic syndrome cell line via the activation of caspases and inhibition of PI3K/Akt and NF-?B pathway proteins.
BIIB021, an Hsp90 inhibitor: A promising therapeutic strategy for blood malignancies (Review).
BIIB021, an orally available, fully synthetic small-molecule inhibitor of the heat shock protein Hsp90.
BIIB021: A novel inhibitor to heat shock protein 90-addicted oncology.
BIK and GRP78 protein expression as possible markers of response to preoperative chemotherapy and survival in breast cancer.
Bim transfer between Bcl-2-like protein and Hsp70 underlines Bcl-2/Hsp70 crosstalk to regulate apoptosis.
Binding of anti-GRP78 autoantibodies to cell surface GRP78 increases tissue factor procoagulant activity via the release of calcium from endoplasmic reticulum stores.
Binding of antigenic peptide to the endoplasmic reticulum-resident protein gp96/GRP94 heat shock chaperone occurs in higher order complexes. Essential role of some aromatic amino acid residues in the peptide-binding site.
Binding of heat shock protein 70 to extracellular phosphatidylserine promotes killing of normoxic and hypoxic tumor cells.
Binding of natural and synthetic inhibitors to human heat shock protein 90 and their clinical application.
Binding of tumor antigen mucin (MUC1) derived peptides to the heat shock protein DnaK.
Binding partners for curcumin in human schwannoma cells: biologic implications.
BIO alleviates inflammation through inhibition of GSK-3? in a rat model of intracerebral hemorrhage.
Biochemical aspects of the neuroprotective mechanism of PTEN-induced kinase-1 (PINK1).
Biodistribution of HPMA Copolymer-Aminohexylgeldanamycin-RGDfK Conjugates for Prostate Cancer Drug Delivery.
Biologic markers of invasive pituitary adenomas involving the sphenoid sinus.
Biological characteristics of heat shock protein 90 in human liver cancer cells.
Biological evaluation of 3-acyl-2-arylamino-1,4-naphthoquinones as inhibitors of Hsp90 chaperoning function.
Biological Evaluation of 5'-(N-Ethylcarboxamido)adenosine Analogues as Grp94-Selective Inhibitors.
Biomarkers That Predict Sensitivity to Heat Shock Protein 90 Inhibitors.
Biophysical analysis of the endoplasmic reticulum-resident chaperone/heat shock protein gp96/GRP94 and its complex with peptide antigen.
Bioresistive identification of heat shock protein 90.
Biotinylated geldanamycin.
BIRB 796 enhances cytotoxicity triggered by bortezomib, heat shock protein (Hsp) 90 inhibitor, and dexamethasone via inhibition of p38 mitogen-activated protein kinase/Hsp27 pathway in multiple myeloma cell lines and inhibits paracrine tumour growth.
Blinded predictions of binding modes and energies of HSP90-? ligands for the 2015 D3R grand challenge.
Blockade of Cripto binding to cell surface GRP78 inhibits oncogenic Cripto signaling via MAPK/PI3K and Smad2/3 pathways.
Blockade of Her2/neu Binding to Hsp90 by Emodin Azide Methyl Anthraquinone Derivative Induces Proteasomal Degradation of Her2/neu.
Blockade of Hsp90 by 17AAG antagonizes MDMX and synergizes with Nutlin to induce p53-mediated apoptosis in solid tumors.
Blockade of PI3K/AKT pathway enhances sensitivity of Raji cells to chemotherapy through down-regulation of HSP70.
Blockage of conformational changes of heat shock protein gp96 on cell membrane by a ?-helix peptide inhibits HER2 dimerization and signaling in breast cancer.
Blocking heat shock protein-90 inhibits the invasive properties and hepatic growth of human colon cancer cells and improves the efficacy of oxaliplatin in p53-deficient colon cancer tumors in vivo.
Blocking HSP90 Addiction Inhibits Tumor Cell Proliferation, Metastasis Development, and Synergistically Acts with Zoledronic Acid to Delay Osteosarcoma Progression.
Blocking NF-?B and Akt by Hsp90 inhibition sensitizes Smac mimetic compound 3-induced extrinsic apoptosis pathway and results in synergistic cancer cell death.
Blocking NF-?B sensitizes non-small cell lung cancer cells to histone deacetylase inhibitor induced extrinsic apoptosis through generation of reactive oxygen species.
Blocking the chaperone kinome pathway: mechanistic insights into a novel dual inhibition approach for supra-additive suppression of malignant tumors.
Boosting Photothermal Theranostics via TICT and Molecular Motions for Photohyperthermia Therapy of Muscle-Invasive Bladder Cancer.
Bortezomib enhances dendritic cell (DC)-mediated induction of immunity to human myeloma via exposure of cell surface heat shock protein 90 on dying tumor cells: therapeutic implications.
Both CD4+ and CD8+ T cell epitopes fused to heat shock cognate protein 70 (hsc70) can function to eradicate tumors.
BRCA1 and HSP90 cooperate in homologous and non-homologous DNA double-strand-break repair and G2/M checkpoint activation.
Brca1 breast tumors contain distinct CD44+/CD24- and CD133+ cells with cancer stem cell characteristics.
c-Abl Mediated Tyrosine Phosphorylation of Aha1 Activates Its Co-chaperone Function in Cancer Cells.
C-C Chemokine Ligand 2 (CCL2) Recruits Macrophage-Membrane-Camouflaged Hollow Bismuth Selenide Nanoparticles To Facilitate Photothermal Sensitivity and Inhibit Lung Metastasis of Breast Cancer.
C-Mannosylated peptides derived from the thrombospondin type 1 repeat interact with Hsc70 to modulate its signaling in RAW264.7 cells.
C-terminal amino acids are essential for human heat shock protein 70 dimerization.
C-terminal domain of SMYD3 serves as a unique HSP90-regulated motif in oncogenesis.
C-terminal HSP90 inhibitor L80 elicits anti-metastatic effects in triple-negative breast cancer via STAT3 inhibition.
C-Terminal HSP90 Inhibitors Block the HIF-1 Hypoxic Response by Degrading HIF-1? through the Oxygen-Dependent Degradation Pathway.
C-terminal modulators of heat shock protein of 90?kDa (HSP90): State of development and modes of action.
C-terminal phosphorylation of Hsp70 and Hsp90 regulates alternate binding to co-chaperones CHIP and HOP to determine cellular protein folding/degradation balances.
C0818, a novel curcumin derivative, induces ROS-dependent cytotoxicity in human hepatocellular carcinoma cells in vitro via disruption of Hsp90 function.
C15-methoxyphenylated 18-deoxy-herbimycin A analogues, their in vitro anticancer activity and heat shock protein 90 binding affinity.
Calcium-activated endoplasmic reticulum stress as a major component of tumor cell death induced by 2,5-dimethyl-celecoxib, a non-coxib analogue of celecoxib.
Calnexin, an ER-induced protein, is a prognostic marker and potential therapeutic target in colorectal cancer.
Calreticulin is involved in invasion of human extravillous trophoblasts through functional regulation of integrin ?1.
Can breast cancer Hsp 27 (Heat Shock Protein 27000) expression influence axillary lymph node status?
Can RNAi-mediated hsp90? knockdown in combination with 17-AAG be a therapy for glioma?
Cancer abolishes the tissue type-specific differences in the phenotype of energetic metabolism.
Cancer Associated Fibroblast-Derived Hepatocyte Growth Factor Inhibits the Paclitaxel-Induced Apoptosis of Lung Cancer A549 Cells by Up-Regulating the PI3K/Akt and GRP78 Signaling on a Microfluidic Platform.
Cancer cell responses to Hsp70 inhibitor JG-98: Comparison with Hsp90 inhibitors and finding synergistic drug combinations.
Cancer cells harboring MET gene amplification activate alternative signaling pathways to escape MET inhibition but remain sensitive to Hsp90 inhibitors.
Cancer cells resistant to therapy promote cell surface relocalization of GRP78 which complexes with PI3K and enhances PI(3,4,5)P3 production.
Cancer Chemoprevention and Nutri-Epigenetics: State of the Art and Future Challenges.
Cancer gene therapy with a heat shock protein gene.
Cancer immunotherapy based on intracellular hyperthermia using magnetite nanoparticles: a novel concept of "heat-controlled necrosis" with heat shock protein expression.
Cancer immunotherapy using irradiated tumor cells secreting heat shock protein 70.
Cancer inhibition through circadian reprogramming of tumor transcriptome with meal timing.
Cancer progression in COVID-19: integrating the roles of renin angiotensin aldosterone system, angiopoietin-2, heat shock protein-27 and epithelial mesenchymal transition.
Cancer proteomics: from identification of novel markers to creation of artifical learning models for tumor classification.
Cancer Takes a Toll on Skeletal Muscle by Releasing Heat Shock Proteins-An Emerging Mechanism of Cancer-Induced Cachexia.
Cancer-associated fibroblasts promote non-small cell lung cancer cell invasion by upregulation of glucose-regulated protein 78 (GRP78) expression in an integrated bionic microfluidic device.
Cancer-selective apoptotic effects of extracellular and intracellular Par-4.
Candidate therapeutic agents for hepatocellular cancer can be identified from phenotype-associated gene expression signatures.
Canine heat shock protein 27 promotes proliferation, migration, and doxorubicin resistance in the canine cell line DTK-F.
Carbon monoxide, generated by heme oxygenase-1, mediates the enhanced permeability and retention effect in solid tumors.
Carboxy-terminus Hsc70 interacting protein exerts a tumor inhibition function in head and neck cancer.
Carcinosarcoma of the urinary bladder: expression of epithelial markers and different expression of heat shock proteins between epithelial and sarcomatous elements.
Casein kinase 2 phosphorylation of Hsp90 threonine 22 modulates chaperone function and drug sensitivity.
Castration-Induced Downregulation of SPARC in Stromal Cells Drives Neuroendocrine Differentiation of Prostate Cancer.
CCAR2/DBC1 and Hsp60 Positively Regulate Expression of Survivin in Neuroblastoma Cells.
CD1A-positive cells and HSP60 (HSPD1) levels in keratoacanthoma and squamous cell carcinoma.
CD20+ Tumor Infiltrating B Lymphocyte in Oral Squamous Cell Carcinoma: Correlation with Clinicopathologic Characteristics and Heat Shock Protein 70 Expression.
Cdc7-Dbf4-mediated phosphorylation of HSP90-S164 stabilizes HSP90-HCLK2-MRN complex to enhance ATR/ATM signaling that overcomes replication stress in cancer.
Celastrol protects against MPTP- and 3-nitropropionic acid-induced neurotoxicity.
Celastrol regulates multiple nuclear transcription factors belonging to HSP90's clients in a dose- and cell type-dependent way.
Celecoxib induces apoptosis but up-regulates VEGF via endoplasmic reticulum stress in human colorectal cancer in vitro and in vivo.
Celecoxib upregulates endoplasmic reticulum chaperones that inhibit celecoxib-induced apoptosis in human gastric cells.
Cell death induced by down-regulation of heat shock protein 70 in lung cancer cell lines is p53-independent and does not require DNA cleavage.
Cell Surface Cdc37 Participates in Extracellular HSP90 Mediated Cancer Cell Invasion.
Cell surface expression of the stress response chaperone GRP78 enables tumor targeting by circulating ligands.
Cell surface GRP78 and Dermcidin cooperate to regulate breast cancer cell migration through Wnt signaling.
Cell surface GRP78 as a biomarker and target for suppressing glioma cells.
Cell Surface GRP78 as a Death Receptor and an Anticancer Drug Target.
Cell surface GRP78 promotes stemness in normal and neoplastic cells.
Cell surface GRP78 promotes tumor cell histone acetylation through metabolic reprogramming: a mechanism which modulates the Warburg effect.
Cell surface GRP78 signaling: An emerging role as a transcriptional modulator in cancer.
Cell surface GRP78: A potential marker of good prognosis and response to chemotherapy in breast cancer.
Cell surface GRP78: An emerging imaging marker and therapeutic target for cancer.
Cell surface heat shock protein 90 modulates prostate cancer cell adhesion and invasion through the integrin-?1/focal adhesion kinase/c-Src signaling pathway.
Cell surface heat shock protein-mediated entry of tumor cell-adapted rotavirus into U-937 cells.
Cell surface heparan sulfate proteoglycans are involved in the extracellular Hsp90-stimulated migration and invasion of cancer cells.
Cell surface localised Hsp70 is a cancer specific regulator of clathrin-independent endocytosis.
Cell surface receptors for molecular chaperones.
Cell surface targeting of heat shock protein gp96 induces dendritic cell maturation and antitumor immunity.
Cell surface-bound heat shock protein 70 (Hsp70) mediates perforin-independent apoptosis by specific binding and uptake of granzyme B.
Cell-type variation in stress responses as a consequence of manipulating GRP78 expression in neuroectodermal cells.
Cellular and molecular chaperone fusion vaccines: targeting resistant cancer cell populations.
Cellular stress stimulates nuclear localization signal (NLS) independent nuclear transport of MRJ.
Cepharanthin enhances thermosensitivity without a resultant reduction in the thermotolerance of a murine mammary carcinoma.
CEUS-Based Radiomics Can Show Changes in Protein Levels in Liver Metastases After Incomplete Thermal Ablation.
Chaetocin enhances dendritic cell function via the induction of heat shock protein and cancer testis antigens in myeloma cells.
Chalcone-templated Hsp90 inhibitors and their effects on gefitinib resistance in non-small cell lung cancer (NSCLC).
Changes in cell culture temperature alter release of inflammatory mediators in murine macrophagic RAW264.7 cells.
Changes in inflammatory mediators following eccentric exercise of the elbow flexors.
Changes in oligosaccharide chains of autoantibodies to GRP78 expressed during progression of malignant melanoma stimulate melanoma cell growth and survival.
Changes in protein expression after neoadjuvant use of aromatase inhibitors in primary breast cancer: a proteomic approach to search for potential biomarkers to predict response or resistance.
Changes in the expression of proteins associated with aerobic glycolysis and cell migration are involved in tumorigenic ability of two glioma cell lines.
Changes in tumor necrosis factor-?, heat shock protein 70, malondialdehyde, and superoxide dismutase in patients with different severities of alcoholic fatty liver disease: a prospective observational study.
Chaperone gp96-independent inhibition of endotoxin response by chaperone-based peptide inhibitors.
Chaperone Mediated Autophagy Substrates and Components in Cancer.
Chaperone protein HSC70 regulates intercellular transfer of Y chromosome antigen DBY.
Chaperone substrate provides missing link for cancer drug discovery.
Chaperone-dependent stabilization and degradation of p53 mutants.
Chaperone-mediated autophagy promotes lung cancer cell survival through selective stabilization of the pro-survival protein, MCL1.
Chaperone-rich cell lysates, immune activation and tumor vaccination.
Chaperones and slow death--a recipe for tumor immunotherapy.
Chaperonin-Co-chaperonin Interactions.
Chaperonin-GroEL as a Smart Hydrophobic Drug Delivery and Tumor Targeting Molecular Machine for Tumor Therapy.
Chaperoning of mutant p53 protein by wild-type p53 protein causes hypoxic tumor regression.
Chaperoning oncogenes: Hsp90 as a target of geldanamycin.
Chaperonopathies and Chaperonotherapy. Hsp60 as Therapeutic Target in Cancer: Potential Benefits and Risks.
Characterization and Biological Activity of the Ribosomal Protein L10a of the White Shrimp: Fenneropenaeus merguiensis De Man During Vitellogenesis.
Characterization and Mechanism of Stress-induced Translocation of 78-kilodalton Glucose Regulated Protein (GRP78) to the Cell Surface.
Characterization and prognostic significance of mortalin, Bcl-2 and Bax in intrahepatic cholangiocarcinoma.
Characterization of celastrol to inhibit HSP90 and CDC37 interaction.
Characterization of Exosomes in Plasma of Patients with Breast, Ovarian, Prostate, Hepatic, Gastric, Colon, and Pancreatic Cancers.
Characterization of Glycolysis-Associated Molecules in the Tumor Microenvironment Revealed by Pan-Cancer Tissues and Lung Cancer Single Cell Data.
Characterization of heat shock protein 110 and glucose-regulated protein 170 as cancer vaccines and the effect of fever-range hyperthermia on vaccine activity.
Characterization of six new loci within the swine major histocompatibility complex class III region.
Characterization of the binding between a 70-kDa heat shock protein, HspA1A, and phosphoinositides.
Characterization of the combined cellular survival effects of benzoquinone-ansamycins and ionizing radiation.
Characterization of the Relationship between the Chaperone and Lipid-Binding Functions of the 70-kDa Heat-Shock Protein, HspA1A.
Characterizing Cell Stress and GRP78 in Glioma to Enhance Tumor Treatment.
Chemical inhibition of HSP90 inhibits TNF-? mediated proliferation and induces apoptosis in human rheumatoid arthritis fibroblast-like synoviocytes.
Chemical Perturbation of Oncogenic Protein Folding: from the Prediction of Locally Unstable Structures to the Design of Disruptors of Hsp90-Client Interactions.
Chemical proteomics-driven discovery of oleocanthal as an Hsp90 inhibitor.
Chemodrug-Gated Biodegradable Hollow Mesoporous Organosilica Nanotheranostics for Multimodal Imaging-Guided Low-Temperature Photothermal Therapy/Chemotherapy of Cancer.
Chemogenomic analysis identifies geldanamycins as substrates and inhibitors of ABCB1.
Chemotherapy Sensitizes Therapy-Resistant Cells to Mild Hyperthermia by Suppressing Heat Shock Protein 27 Expression in Triple-Negative Breast Cancer.
Chicken HSP70 DNA vaccine inhibits tumor growth in a canine cancer model.
CHIP functions as a novel suppressor of tumour angiogenesis with prognostic significance in human gastric cancer.
CHIP is a novel tumor suppressor in pancreatic cancer through targeting EGFR.
Chiral resolution and pharmacological characterization of the enantiomers of the Hsp90 inhibitor 2-amino-7-[4-fluoro-2-(3-pyridyl)phenyl]-4-methyl-7,8-dihydro-6H-quinazolin-5-one oxime.
Chitosan-functionalised single-walled carbon nanotube-mediated drug delivery of SNX-2112 in cancer cells.
CHM-1 Suppresses Formation of Cell Surface-associated GRP78-p85? Complexes, Inhibiting PI3K-AKT Signaling and Inducing Apoptosis of Human Nasopharyngeal Carcinoma Cells.
Choline kinase inhibition induces exacerbated endoplasmic reticulum stress and triggers apoptosis via CHOP in cancer cells.
Circulating GRP78 antibodies from ovarian cancer patients: a promising tool for cancer cell targeting drug delivery system?
Circulating heat shock proteins in women with a history of recurrent vulvovaginitis.
Circulating human heat shock protein 60 in the plasma of British civil servants: relationship to physiological and psychosocial stress.
Circulating level of heat shock protein 27 is elevated in dogs with mammary tumors.
Circulating mitochondrial stress 70 protein/mortalin and cytosolic Hsp70 in blood: Risk indicators in colorectal cancer.
Circulating mortalin autoantibody--a new serological marker of liver cirrhosis.
Cisplatin induces the small heat shock protein hsp25 and thermotolerance in Ehrlich ascites tumor cells.
Cisplatin-induced senescence in ovarian cancer cells is mediated by GRP78.
CK2: The kinase controlling the Hsp90 chaperone machinery.
Cks1 proteasomal degradation is induced by inhibiting Hsp90-mediated chaperoning in cancer cells.
Cleavage of HSP90? induced by histone deacetylase inhibitor and proteasome inhibitor modulates cell growth and apoptosis.
Client Proteins and Small Molecule Inhibitors Display Distinct Binding Preferences for Constitutive and Stress-Induced HSP90 Isoforms and Their Conformationally Restricted Mutants.
Clients and Oncogenic Roles of Molecular Chaperone gp96/grp94.
Clinical development of 17-allylamino, 17-demethoxygeldanamycin.
Clinical significance of HSP27 expression in colorectal cancer.
Clinical Significance of Monitoring Circulating Free DNA and Plasma Heat Shock Protein 90alpha in Patients with Esophageal Squamous Cell Carcinoma.
Clinical significance of serum dynamics of HSP90a level in esophageal squamous cell carcinoma patients treated with definitive chemoradiotherapy.
Clinical, Prognostic and Therapeutic Significance of Heat Shock Proteins in Cancer.
Clinical, prognostic, and therapeutic significance of heat shock protein 27 in bladder cancer.
Clinicopathologic significance of TRAP1 expression in colorectal cancer: a large scale study of human colorectal adenocarcinoma tissues.
Clinicopathological and biological features of DNA tetraploid colorectal cancers.
Clinicopathological and genetic characteristics of mucinous carcinomas in the colorectum.
Clinicopathological and prognostic significance of heat shock protein 27 (HSP27) expression in non-small cell lung cancer: a systematic review and meta-analysis.
Clinicopathological significance of endoplasmic reticulum stress proteins in ovarian carcinoma.
Clusterin as a therapeutic target.
Clusterin as modulator of carcinogenesis: A potential avenue for targeted cancer therapy.
Clusterin Inhibition using OGX-011 Synergistically Enhances Hsp90 Inhibitor Activity by Suppressing the Heat Shock Response in Castrate Resistant Prostate Cancer.
Clusterin mediates TGF-?-induced epithelial-mesenchymal transition and metastasis via Twist1 in prostate cancer cells.
Clusterin Protects Hepatocellular Carcinoma Cells from Endoplasmic Reticulum Stress Induced Apoptosis through GRP78.
Co-chaperones TIMP2 and AHA1 Competitively Regulate Extracellular HSP90:Client MMP2 Activity and Matrix Proteolysis.
Co-crystalization and in vitro biological characterization of 5-aryl-4-(5-substituted-2-4-dihydroxyphenyl)-1,2,3-thiadiazole hsp90 inhibitors.
Co-delivery of TRAIL and siHSP70 using hierarchically modular assembly formulations achieves enhanced TRAIL-resistant cancer therapy.
Co-segregation of tumor immunogenicity with expression of inducible but not constitutive hsp70 in rat colon carcinomas.
Codelivery of GRP78 siRNA and docetaxel via RGD-PEG-DSPE/DOPA/CaP nanoparticles for the treatment of castration-resistant prostate cancer.
Colon cancer cells expressing cell surface GRP78 as a marker for reduced tumorigenicity.
Colorectal cancers with microsatellite instability display mRNA expression signatures characteristic of increased immunogenicity.
Combination of a Selective HSP90?/? Inhibitor and a RAS-RAF-MEK-ERK Signaling Pathway Inhibitor Triggers Synergistic Cytotoxicity in Multiple Myeloma Cells.
Combination of Anti-Cancer Drugs with Molecular Chaperone Inhibitors.
Combination of apigenin treatment with therapeutic HPV DNA vaccination generates enhanced therapeutic antitumor effects.
Combination of Fish Oil and Selenium Enhances Anticancer Efficacy and Targets Multiple Signaling Pathways in Anti-VEGF Agent Treated-TNBC Tumor-Bearing Mice.
Combination of hyperthermia and bortezomib results in additive killing in mantle cell lymphoma cells.
Combination of TRAP1 and ERCC1 Expression Predicts Clinical Outcomes in Metastatic Colorectal Cancer Treated with Oxaliplatin/5-Fluorouracil.
Combination of trastuzumab and tanespimycin (17-AAG, KOS-953) is safe and active in trastuzumab-refractory HER-2 overexpressing breast cancer: a phase I dose-escalation study.
Combination of Withaferin-A and CAPE Provides Superior Anticancer Potency: Bioinformatics and Experimental Evidence to Their Molecular Targets and Mechanism of Action.
Combination radiofrequency (RF) ablation and IV liposomal heat shock protein suppression: Reduced tumor growth and increased animal endpoint survival in a small animal tumor model.
Combination therapies with HSP90 inhibitors against colorectal cancer.
Combination therapy with HSP90 inhibitor 17-DMAG reconditions the tumor microenvironment to improve recruitment of therapeutic T cells.
Combination treatment with doxorubicin and gamitrinib synergistically augments anticancer activity through enhanced activation of Bim.
Combinatorial attack on multistep oncogenesis by inhibiting the Hsp90 molecular chaperone.
Combinatorial drug design targeting multiple cancer signaling networks controlled by mitochondrial Hsp90.
Combinatorial inhibition of mTORC2 and Hsp90 leads to a distinctly effective therapeutic strategy in malignant pheochromocytom.
Combinatorial targeting of nuclear export and translation of RNA inhibits aggressive B-cell lymphomas.
Combined ?-methylacyl-CoA racemase inhibition and docetaxel treatment reduce cell proliferation and decrease expression of heat shock protein 27 in androgen receptor-variant-7-positive prostate cancer cells.
Combined chemical-genetic approach identifies cytosolic HSP70 dependence in rhabdomyosarcoma.
Combined Effect of Hsp90 Inhibitor Geldanamycin and Parthenolide via Reactive Oxygen Species-Mediated Apoptotic Process on Epithelial Ovarian Cancer Cells.
Combined effect of tumor necrosis factor (TNF)-alpha and heat shock protein (HSP)-70 in reducing apoptotic injury in hypoxia: a cell culture study.
Combined effects of 17-DMAG and TNF on cells through a mechanism related to the NF-kappaB pathway.
Combined effects of mulch film-derived microplastics and atrazine on oxidative stress and gene expression in earthworm (Eisenia fetida).
Combined HSP90 and kinase inhibitor therapy: Insights from The Cancer Genome Atlas.
Combined in silico and experimental approach for drug design: the binding mode of peptidic and non-peptidic inhibitors to hsp90 N-terminal domain.
Combined inhibition of EGFR and CK2 augments the attenuation of PI3K-Akt-mTOR signaling and the killing of cancer cells.
Combined inhibition of extracellular signal-regulated kinases and HSP90 sensitizes human colon carcinoma cells to ionizing radiation.
Combined inhibition of heat shock proteins 90 and 70 leads to simultaneous degradation of the oncogenic signaling proteins involved in muscle invasive bladder cancer.
Combined inhibition of Hsp90 and heme oxygenase-1 induces apoptosis and endoplasmic reticulum stress in melanoma.
Combined inhibition of Wee1 and Hsp90 activates intrinsic apoptosis in cancer cells.
Combined lentiviral and RNAi technologies for the delivery and permanent silencing of the hsp25 gene.
Combined pharmacophore and structure-guided studies to identify diverse HSP90 inhibitors.
Combined PI3K/Akt and Hsp90 targeting synergistically suppresses essential functions of alloreactive T cells and increases Tregs.
Combined use of heat-shock protein 70 and glutamine synthetase is useful in the distinction of typical hepatocellular adenoma from atypical hepatocellular neoplasms and well-differentiated hepatocellular carcinoma.
Combining an Hsp70 inhibitor with either an N- or C-terminal Hsp90 inhibitor produces mechanistically distinct phenotypes.
Combining cytotoxics and 17-allylamino, 17-demethoxygeldanamycin: sequence and tumor biology matters. Commentary re: P. Münster et al., Modulation of Hsp90 function by ansamycins sensitizes breast cancer cells to chemotherapy-induced apoptosis in an RB- and schedule-dependent manner. Clin. Cancer Res., 7: 2228-2236, 2001.
Combining GRP78 suppression and MK2206-induced Akt inhibition decreases doxorubicin-induced P-glycoprotein expression and mitigates chemoresistance in human osteosarcoma.
Combining hit identification strategies: fragment-based and in silico approaches to orally active 2-aminothieno[2,3-d]pyrimidine inhibitors of the Hsp90 molecular chaperone.
Combining radiation and molecular targeting in cancer therapy.
Combining Trail with PI3 Kinase or HSP90 inhibitors enhances apoptosis in colorectal cancer cells via suppression of survival signaling.
Commercial Dairy Cow Milk microRNAs Resist Digestion under Simulated Gastrointestinal Tract Conditions.
Comparative effects of SNX-7081 and SNX-2112 on cell cycle, apoptosis and Hsp90 client proteins in human cancer cells.
Comparative proteomic analysis for the detection of biomarkers in pancreatic ductal adenocarcinomas.
Comparative Study of 17-AAG and NVP-AUY922 in Pancreatic and Colorectal Cancer Cells: Are There Common Determinants of Sensitivity?
Comparative study of stress and immune-related transcript outcomes triggered by Vibrio anguillarum bacterin and air exposure stress in liver and spleen of gilthead seabream (Sparus aurata), zebrafish (Danio rerio) and rainbow trout (Oncorhynchus mykiss).
Comparison of cell cycle components, apoptosis and cytoskeleton-related molecules and therapeutic effects of flavopiridol and geldanamycin on the mouse fibroblast, lung cancer and embryonic stem cells.
Comparison of inhibitory effect of 17-DMAG nanoparticles and free 17-DMAG in HSP90 gene expression in lung cancer.
Comparison of inhibitory effects of 17-AAG nanoparticles and free 17-AAG on HSP90 gene expression in breast cancer.
Comparison of the activity of three different HSP70 inhibitors on apoptosis, cell cycle arrest, autophagy inhibition, and HSP90 function.
Comparison of the expression of 5 heat shock proteins in benign and malignant salivary gland tumor tissues.
Comparison of the stress response in patients undergoing gynecological laparoscopic surgery using carbon dioxide pneumoperitoneum or abdominal wall-lifting methods.
Compartmentalized cancer drug discovery targeting mitochondrial Hsp90 chaperones.
Complementary autophagy inhibition and glucose metabolism with rattle-structured polydopamine@mesoporous silica nanoparticles for augmented low-temperature photothermal therapy and in vivo photoacoustic imaging.
Complex of C60 Fullerene with Doxorubicin as a Promising Agent in Antitumor Therapy.
Compound ranking based on a new mathematical measure of effectiveness using time course data from cell-based assays.
Comprehensive review on the HSC70 functions, interactions with related molecules and involvement in clinical diseases and therapeutic potential.
Compromising the constitutive p16INK4a expression sensitizes human neuroblastoma cells to Hsp90 inhibition and promotes premature senescence.
Computational aided mechanistic understanding of Camellia sinensis bioactive compounds against co-chaperone p23 as potential anticancer agent.
Computational Modeling of the Hsp90 Interactions with Cochaperones and Small-Molecule Inhibitors.
Computational Polypharmacology Analysis of the Heat Shock Protein 90 Interactome.
Computational predictions of corroles as a class of Hsp90 inhibitors.
Concurrent MEK and autophagy inhibition is required to restore cell death associated danger-signalling in Vemurafenib-resistant melanoma cells.
Conformational dynamics of full-length inducible human Hsp70 derived from microsecond molecular dynamics simulations in explicit solvent.
Conformational dynamics of the molecular chaperone Hsp90 in complexes with a co-chaperone and anticancer drugs.
Conformational dynamics of the molecular chaperone Hsp90.
Conjugation with polyamines enhances the antitumor activity of naphthoquinones against human glioblastoma cells.
Consecutive Day HSP90 Inhibitor Administration Improves Efficacy in Murine Models of KIT-Driven Malignancies and Canine Mast Cell Tumors.
Consequences of heat shock protein 72 (Hsp72) expression and activity on stress-induced apoptosis in CD30(+) NPM-ALK(+) anaplastic large-cell lymphomas.
Constitutively-active androgen receptor variants function independently of the HSP90 chaperone but do not confer resistance to HSP90 inhibitors.
Contribution of the Type II Chaperonin, TRiC/CCT, to Oncogenesis.
Contributions of co-chaperones and post-translational modifications towards Hsp90 drug sensitivity.
Control of Tumor Bioenergetics and Survival Stress Signaling by Mitochondrial HSP90s.
Controlled CRISPR-Cas9 Ribonucleoprotein Delivery for Sensitized Photothermal Therapy.
Cooperation between Hsp90 and mortalin/GRP75 in resistance to cell death induced by complement C5b-9.
Cooperative Enhancement of Radiosensitivity After Combined Treatment of 17-(Allylamino)-17-Demethoxygeldanamycin and Celecoxib in Human Lung and Colon Cancer Cell Lines.
Cooperative Interactions between Androgen Receptor (AR) and Heat-Shock Protein 27 Facilitate AR Transcriptional Activity.
Cooperative regulation of the interferon regulatory factor-1 tumor suppressor protein by core components of the molecular chaperone machinery.
Coordinated Conformational Processing of the Tumor Suppressor Protein p53 by the Hsp70 and Hsp90 Chaperone Machineries.
Coordinated regulation of serum- and glucocorticoid-inducible kinase 3 by a C-terminal hydrophobic motif and Hsp90-Cdc37 chaperone complex.
Correction to "CXL146, a Novel 4H-Chromene Derivative, Targets GRP78 to Selectively Eliminate Multidrug-Resistant Cancer Cells".
Correction to: Reflections and Outlook on Targeting HSP90, HSP70 and HSF1 in Cancer: A Personal Perspective.
Correction: A Phase I Study of the Heat Shock Protein 90 Inhibitor Alvespimycin (17-DMAG) Given Intravenously to Patients with Advanced Solid Tumors.
Correction: Lens Epithelium-Derived Growth Factor Is an Hsp70-2 Regulated Guardian of Lysosomal Stability in Human Cancer.
Correlated fluorescence microscopy and multi-ion beam secondary ion mass spectrometry imaging reveals phosphatidylethanolamine increases in the membrane of cancer cells over-expressing the molecular chaperone subunit CCT?.
Correlation between clinicopathology and expression of heat shock protein 72 and glycoprotein 96 in human esophageal squamous cell carcinoma.
Correlation between clinicopathology and expression of heat shock protein 72 and glycoprotein 96 in human gastric adenocarcinoma.
Correlation between the progressive cytoplasmic expression of a novel small heat shock protein (Hsp16.2) and malignancy in brain tumors.
Correlation of fragile histidine triad (Fhit) protein structural features with effector interactions and biological functions.
Correlation of heat shock protein 70 expression with estrogen receptor levels in invasive human breast cancer.
Correlation of Hsp70 Serum Levels with Gross Tumor Volume and Composition of Lymphocyte Subpopulations in Patients with Squamous Cell and Adeno Non-Small Cell Lung Cancer.
Correlation of malignant phenotypes of human tumour cell lines with augmented expression of Hsp72 protein measured by laser scanning cytometry.
Correlation of the protein expression of GRP78 and BIK/NBK with prognostic markers in patients with breast cancer and neoadjuvant chemotherapy.
Corrigendum: Landscape of the mitochondrial Hsp90 metabolome in tumours.
Cotargeting HSP90 and Its Client Proteins for Treatment of Prostate Cancer.
Could the Anti-Chaperone VER155008 Replace Temozolomide for Glioma Treatment.
Coupling apoptosis resistance to the cellular stress response: the IAP-Hsp90 connection in cancer.
CPUY201112, a novel synthetic small-molecule compound and inhibitor of heat shock protein Hsp90, induces p53-mediated apoptosis in MCF-7 cells.
Cracking the Chaperone Code: Cellular Roles for Hsp70 Phosphorylation.
Creation of Recombinant Chaperone Vaccine Using Large Heat Shock Protein for Antigen-Targeted Cancer Immunotherapy.
CRINEPT-TROSY NMR reveals p53 core domain bound in an unfolded form to the chaperone Hsp90.
CRIPTO and its signaling partner GRP78 drive the metastatic phenotype in human osteotropic prostate cancer.
Cripto haploinsufficiency affects in vivo colon tumor development.
Cripto stabilizes GRP78 on the cell membrane.
Critical Role of Mortalin/GRP75 In Endothelial Cell Dysfunction Associated With Acute Lung Injury.
Critical role of the stress chaperone GRP78/BiP in tumor proliferation, survival, and tumor angiogenesis in transgene-induced mammary tumor development.
Cross-presentation of the oncofoetal tumor antigen 5T4 from irradiated prostate cancer cells - a key role for heat shock protein 70 and receptor CD91.
Cross-priming of minor histocompatibility antigen-specific cytotoxic T cells upon immunization with the heat shock protein gp96.
Cryptotanshinone-Induced p53-Dependent Sensitization of Colon Cancer Cells to Apoptotic Drive by Regulation of Calpain and Calcium Homeostasis.
Crystal structure of an Hsp90-geldanamycin complex: targeting of a protein chaperone by an antitumor agent.
Crystal structure of an Hsp90-nucleotide-p23/Sba1 closed chaperone complex.
Crystal Structure of the Nucleotide Binding Domain of Mortalin, the mitochondrial Hsp70 chaperone.
Crystallization and preliminary X-ray diffraction analysis of Trap1 complexed with Hsp90 inhibitors.
CUDC-305, a novel synthetic HSP90 inhibitor with unique pharmacologic properties for cancer therapy.
Curcumin Affects HSP60 Folding Activity and Levels in Neuroblastoma Cells.
Curcumin and Glu-GNPs Induce Radiosensitivity against Breast Cancer Stem-Like Cells.
Curcumin inhibits lung cancer cell invasion and metastasis through the tumor suppressor HLJ1.
Curcumin suppresses proliferation and invasion in non-small cell lung cancer by modulation of MTA1-mediated Wnt/?-catenin pathway.
Current Strategies to Overcome Resistance to ALK-Inhibitor Agents.
Current Understanding of HSP90 as a Novel Therapeutic Target: An Emerging Approach for the Treatment of Cancer.
Cutting edge: tumor secreted heat shock-fusion protein elicits CD8 cells for rejection.
CXL146, a Novel 4H-Chromene Derivative, Targets GRP78 to Selectively Eliminate Multidrug-Resistant Cancer Cells.
Cyclophosphamide inhibits the progression of Meniere's disease by reducing the generation of circulating immune complex.
Cysteine Proteases from V. cundinamarcensis (C. candamarcensis) Inhibit Melanoma Metastasis and Modulate Expression of Proteins Related to Proliferation, Migration and Differentiation.
Cytokine and adhesion molecule expression in human monocytes and endothelial cells stimulated with bacterial heat shock proteins.
Cytokine synthesis in the liver of endotoxin-tolerant and normal rats during hemorrhagic shock.
Cytokines, Chaperones and Neuroinflammatory Responses in Heroin-Related Death: What Can We Learn from Different Patterns of Cellular Expression?
Cytoplasmic sequestration of the tumor suppressor p53 by a heat shock protein 70 family member, mortalin, in human colorectal adenocarcinoma cell lines.
Cytoprotection and regulation of heat shock proteins induced by heat shock in human breast cancer T47-D cells: role of [Ca2+]i and protein kinases.
Cytoprotective mitochondrial chaperone TRAP-1 as a novel molecular target in localized and metastatic prostate cancer.
Cytosolic Hsp60 is involved in the NF-kappaB-dependent survival of cancer cells via IKK regulation.
Cytosolic-nuclear tumor promoter-specific binding protein: association with the 90 kDa heat shock protein and translocation into nuclei by treatment with 12-O-tetradecanoylphorbol 13-acetate.
Cytotoxic activity to acute myeloid leukemia cells by Antp-TPR hybrid peptide targeting Hsp90.
Cytotoxic T cell responses against mesothelioma by apoptotic cell-pulsed dendritic cells.
Cytotoxic T lymphocyte recognition of non-Hodgkin's B cell lymphomas.
DCZ3112, a novel Hsp90 inhibitor, exerts potent antitumor activity against HER2-positive breast cancer through disruption of Hsp90-Cdc37 interaction.
DCZ5248, a novel dual inhibitor of Hsp90 and autophagy, exerts antitumor activity against colon cancer.
Death by chaperone: HSP90, HSP70 or both?
Debio-0932, a second generation oral Hsp90 inhibitor, induces apoptosis in MCF-7 and MDA-MB-231 cell lines.
Deciphering the Inhibition Mechanism of under Trial Hsp90 Inhibitors and Their Analogues: A Comparative Molecular Dynamics Simulation.
Decoding c-Myc networks of cell cycle and apoptosis regulated genes in a transgenic mouse model of papillary lung adenocarcinomas.
Decrease of heat shock protein levels and cell populations by wine phenolic extracts.
Decreased GRP78 protein expression is a potential prognostic marker of oral squamous cell carcinoma in Taiwan.
Definition of extracellular localized epitopes of Hsp70 involved in an NK immune response.
Degradation of HIF-1alpha under hypoxia combined with induction of Hsp90 polyubiquitination in cancer cells by hypericin: a unique cancer therapy.
Deguelin Analogue SH-1242 Inhibits Hsp90 Activity and Exerts Potent Anticancer Efficacy with Limited Neurotoxicity.
Deletion of the mitochondrial chaperone TRAP-1 uncovers global reprogramming of metabolic networks.
Demethoxycurcumin: A naturally occurring curcumin analogue with antitumor properties.
Demonstration of selective protein complexes of p53 with 73 kDa heat shock cognate protein, but not with 72 kDa heat shock protein in human tumor cells.
Dendritic cells combined with doxorubicin induces immunogenic cell death and exhibits antitumor effects for osteosarcoma.
Dendritic-tumor fusion cells derived heat shock protein70-peptide complex has enhanced immunogenicity.
Deoxyribonuclease 1-Mediated Clearance of Circulating Chromatin Prevents From Immune Cell Activation and Pro-inflammatory Cytokine Production, a Phenomenon Amplified by Low Trap1 Activity: Consequences for Systemic Lupus Erythematosus.
Dephosphorylation of the small heat shock protein hsp25 by calcium/calmodulin-dependent (type 2B) protein phosphatase.
Design and biological testing of peptidic dimerization inhibitors of human Hsp90 that target the C-terminal domain.
Design and synthesis of Grp94 selective inhibitors based on Phe199 induced fit mechanism and their anti-inflammatory effects.
Design and synthesis of neolamellarin a derivatives targeting heat shock protein 90.
Design and synthesis of piperidine derivatives as novel human heat shock protein 70 inhibitors for the treatment of drug-resistant tumors.
Design and synthesis of pyrimidinyl acyl thioureas as novel Hsp90 inhibitors in invasive ductal breast cancer and its bone metastasis.
Design of Disruptors of the Hsp90-Cdc37 Interface.
Design, purification and assessment of GRP78 binding peptide-linked Subunit A of Subtilase cytotoxic for targeting cancer cells.
Design, synthesis and bioevaluation of inhibitors targeting HSP90-CDC37 protein-protein interaction based on a hydrophobic core.
Design, synthesis and biological evaluation of alkylamino biphenylamides as Hsp90 C-terminal inhibitors.
Design, synthesis and biological evaluation of biphenylamide derivatives as Hsp90 C-terminal inhibitors.
Design, synthesis and molecular mechanisms of novel dual inhibitors of heat shock protein 90/phosphoinositide 3-kinase alpha (Hsp90/PI3K?) against cutaneous melanoma.
Design, Synthesis and Pharmacological Evaluation of Novel Hsp90N-terminal Inhibitors Without Induction of Heat Shock Response.
Design, synthesis, and biological evaluation of a series of resorcinol-based N-benzyl benzamide derivatives as potent Hsp90 inhibitors.
Design, synthesis, and biological evaluation of hydroquinone derivatives of 17-amino-17-demethoxygeldanamycin as potent, water-soluble inhibitors of Hsp90.
Design, synthesis, and biological evaluation of ring-constrained novobiocin analogues as hsp90 C-terminal inhibitors.
Design, synthesis, and evaluation of small molecule Hsp90 probes.
Design, synthesis, and molecular docking studies of novel pyrazolyl 2-aminopyrimidine derivatives as HSP90 inhibitors.
Design, synthesis, and structure-activity relationships for chimeric inhibitors of hsp90.
Designed hybrid TPR peptide targeting Hsp90 as a novel anticancer agent.
Destabilization of ROR1 enhances activity of Ibrutinib against chronic lymphocytic leukemia in vivo.
Destabilization of the Epidermal Growth Factor Receptor (EGFR) by a Peptide That Inhibits EGFR Binding to Heat Shock Protein 90 and Receptor Dimerization.
Detecting the Potential Pharmacological Synergy of Drug Combination by Viability Assays In Vitro.
Detection of cathepsin B up-regulation in neoplastic thyroid tissues by proteomic analysis.
Detection of irradiation-induced, membrane heat shock protein 70 (Hsp70) in mouse tumors using Hsp70 Fab fragment.
Detection of the ATPase activity of the molecular chaperones Hsp90 and Hsp72 using the TranscreenerTM ADP assay kit.
Detergent addition to tryptic digests and ion mobility separation prior to MS/MS improves peptide yield and protein identification for in situ proteomic investigation of frozen and formalin-fixed paraffin-embedded adenocarcinoma tissue sections.
Determining the neuroprotective effects of dextromethorphan in lipopolysaccharide?stimulated BV2 microglia.
Development and application of Hsp90 inhibitors.
Development and characterization of a novel C-terminal inhibitor of Hsp90 in androgen dependent and independent prostate cancer cells.
Development and optimization of a useful assay for determining Hsp90's inherent ATPase activity.
Development of 17-allylamino-17-demethoxygeldanamycin hydroquinone hydrochloride (IPI-504), an anti-cancer agent directed against Hsp90.
Development of a Bifunctional Andrographolide-Based Chemical Probe for Pharmacological Study.
Development of a biosensor platform based on ITO sheets modified with 3-glycidoxypropyltrimethoxysilane for early detection of TRAP1.
Development of a Cell-Based Ligand-Screening System for Identifying Hsp90 Inhibitors.
Development of a fluorescence polarization assay for the molecular chaperone Hsp90.
Development of a Grp94 inhibitor.
Development of a high-throughput screening cancer cell-based luciferase refolding assay for identifying Hsp90 inhibitors.
Development of a mitochondria-targeted Hsp90 inhibitor based on the crystal structures of human TRAP1.
Development of a purine-scaffold novel class of Hsp90 binders that inhibit the proliferation of cancer cells and induce the degradation of Her2 tyrosine kinase.
Development of new mouse lung tumor models expressing EGFR T790M mutants associated with clinical resistance to kinase inhibitors.
Development of noviomimetics that modulate molecular chaperones and manifest neuroprotective effects.
Development of Novobiocin Analogues That Manifest Anti-proliferative Activity against Several Cancer Cell Lines.
Development of Phenyl Cyclohexylcarboxamides as a Novel Class of Hsp90 C-terminal Inhibitors.
Development of purine-scaffold small molecule inhibitors of Hsp90.
Development of pyrazolo[3,4-d]pyrimidine-6-amine-based TRAP1 inhibitors that demonstrate in vivo anticancer activity in mouse xenograft models.
Development of radicicol analogues.
Development of small molecule Hsp90 inhibitors: utilizing both forward and reverse chemical genomics for drug identification.
DHA induces apoptosis by altering the expression and cellular location of GRP78 in colon cancer cell lines.
Diabetes mellitus in cystic fibrosis: genetic and immunological markers.
Diagnostic and prognostic value of heat shock protein 90? in malignant melanoma.
Diagnostic management of benign and malignant pheochromocytoma.
Diagnostic Value of Glypican3, Heat Shock Protein 70 and Glutamine Synthetase in Hepatocellular Carcinoma Arising in Cirrhotic and Non-Cirrhotic Livers.
Diagnostic value of plasma HSP90? levels for detection of hepatocellular carcinoma.
Diagnostic, clinicopathologic, therapeutic and prognostic value of Plasma Heat Shock Protein 90 levels in patients with advanced Gastrointestinal Carcinoma.
Dibutyryl cyclic adenosine monophosphate protects mice against tumor necrosis factor-alpha-induced hepatocyte apoptosis accompanied by increased heat shock protein 70 expression.
Dicoumarol down-regulates human PTTG1/Securin mRNA expression through inhibition of Hsp90.
Dietary compound isoliquiritigenin targets GRP78 to chemosensitize breast cancer stem cells via ?-catenin/ABCG2 signaling.
Dietary garlic and chitosan enhanced the antioxidant capacity, immunity, and modulated the transcription of HSP70 and Cytokine genes in Zearalenone-intoxicated European seabass.
Dietary resistant starch type 3 prevents tumor induction by 1,2-dimethylhydrazine and alters proliferation, apoptosis and dedifferentiation in rat colon.
Dietary supplemental microalgal astaxanthin modulates molecular profiles of stress, inflammation, and lipid metabolism in broiler chickens and laying hens under high ambient temperatures.
Dietary supplementation of black mulberry (Morus nigra) syrup improves the growth performance, innate immune response, antioxidant status, gene expression responses, and disease resistance of Nile tilapia (Oreochromis niloticus).
Dietary therapeutic dose of oxytetracycline negatively influences the antioxidant capacity and immune-related genes expression in Nile tilapia Oreochromis niloticus (L.).
Diferuloylmethane augments the cytotoxic effects of piplartine isolated from Piper chaba.
Differences in glycosylation patterns of heat shock protein, gp96: implications for prostate cancer prevention.
Different concentrations of two small stress proteins, alphaB crystallin and HSP27 in human urological tumor tissues.
Different effect of glutamine on macrophage tumor necrosis factor-alpha release and heat shock protein 72 expression in vitro and in vivo.
Different expression of CD44, ICAM-1, and HSP60 on primary tumor and metastases of a human pancreatic carcinoma growing in scid mice.
Different immunohistochemical levels of Hsp60 and Hsp70 in a subset of brain tumors and putative role of Hsp60 in neuroepithelial tumorigenesis.
Different responses of apoptotic, inflammatory and heat shock protein gene expression to a single bout of high-intensity interval exercise between physically active and inactive men.
Differential effect of acute and permanent heat shock protein 70 overexpression in tumor cells on lysability by cytotoxic T lymphocytes.
Differential expression of alphaB-crystallin and Hsp27-1 in anaplastic thyroid carcinomas because of tumor-specific alphaB-crystallin gene (CRYAB) silencing.
Differential Expression of Heat Shock Protein 27 in Oral Epithelial Dysplasias and Squamous Cell Carcinoma.
Differential expression of heat shock protein 70 (hsp70) in human monocytes rendered apoptotic by IL-4 or serum deprivation.
Differential expression of heat shock protein 90 isoforms in small cell lung cancer.
Differential expression of HSP90 isoforms and their correlations with clinicopathologic factors in patients with colorectal cancer.
Differential expression of immune system-related components in midtrimester amniotic fluid from singleton and twin pregnancies.
Differential expression of Janus kinase 3 (JAK3), matrix metalloproteinase 13 (MMP13), heat shock protein 60 (HSP60), and mouse double minute 2 (MDM2) in human colorectal cancer progression using human cancer cDNA microarrays.
Differential heat shock protein localization in chronic lymphocytic leukemia.
Differential influence of anticancer treatments and angiogenesis on the seric titer of autoantibody used as tumor and metastasis biomarker.
Differential mitochondrial proteome analysis of human lung adenocarcinoma and normal bronchial epithelium cell lines using quantitative mass spectrometry.
Differential MyD88/IRAK4 requirements for cross-priming and tumor rejection induced by heat shock protein 70-model antigen fusion protein.
Differential protein expression in primary breast cancer and matched axillary node metastasis.
Differential protein expression using proteomics from a crustacean brine shrimp (Artemia sinica) under CO2-driven seawater acidification.
Differential roles of heat shock protein 70 in the in vitro nuclear import of glucocorticoid receptor and simian virus 40 large tumor antigen.
Differential up-regulation of cytosolic and membrane-bound heat shock protein 70 in tumor cells by anti-inflammatory drugs.
Differential up-regulation of HLA-DM, invariant chain, and CD83 on myeloid and plasmacytoid dendritic cells from peripheral blood.
Differentially expressed genes associated with human lung cancer.
Differentially expressed genes in asbestos-induced tumorigenic human bronchial epithelial cells: implication for mechanism.
Differentially expressed soluble proteins in aortic cells from atherosclerosis-susceptible and resistant pigeons.
Dihydroquinone ansamycins: toward resolving the conflict between low in vitro affinity and high cellular potency of geldanamycin derivatives.
Diosgenin inhibits tumor angiogenesis through regulating GRP78-mediated HIF-1? and VEGF/VEGFR signaling pathways.
Direct regulation of HSP60 expression by c-MYC induces transformation.
Discorhabdin N, a South African Natural Compound, for Hsp72 and Hsc70 Allosteric Modulation: Combined Study of Molecular Modeling and Dynamic Residue Network Analysis.
Discovering High Potent Hsp90 Inhibitors as Antinasopharyngeal Carcinoma Agents through Fragment Assembling Approach.
Discovery and Bioevaluation of Novel Pyrazolopyrimidine Analogs as Competitive Hsp90 Inhibitors Through Shape-Based Similarity Screening.
Discovery and design of novel HSP90 inhibitors using multiple fragment-based design strategies.
Discovery and development of heat shock protein 90 inhibitors.
Discovery and development of Hsp90 inhibitors: a promising pathway for cancer therapy.
Discovery and development of purine-scaffold Hsp90 inhibitors.
Discovery and development of pyrazole-scaffold Hsp90 inhibitors.
Discovery and optimization of 4,5-diarylisoxazoles as potent dual inhibitors of pyruvate dehydrogenase kinase and heat shock protein 90.
Discovery and validation of small-molecule heat-shock protein 90 inhibitors through multimodality molecular imaging in living subjects.
Discovery of (2,4-dihydroxy-5-isopropylphenyl)-[5-(4-methylpiperazin-1-ylmethyl)-1,3-dihydroisoindol-2-yl]methanone (AT13387), a novel inhibitor of the molecular chaperone Hsp90 by fragment based drug design.
Discovery of (2S)-1-[4-(2-{6-Amino-8-[(6-bromo-1,3-benzodioxol-5-yl)sulfanyl]-9H-purin-9-yl}ethyl)piperidin-1-yl]-2-hydroxypropan-1-one (MPC-3100), a Purine-Based Hsp90 Inhibitor.
Discovery of 2',4'-dimethoxychalcone as a Hsp90 inhibitor and its effect on iressa-resistant non-small cell lung cancer (NSCLC).
Discovery of 2-((4-resorcinolyl)-5-aryl-1,2,3-triazol-1-yl)acetates as potent Hsp90 inhibitors with selectivity over TRAP1.
Discovery of 3-Ethyl-4-(3-isopropyl-4-(4-(1-methyl-1 H-pyrazol-4-yl)-1 H-imidazol-1-yl)-1 H-pyrazolo[3,4- b]pyridin-1-yl)benzamide (TAS-116) as a Potent, Selective, and Orally Available HSP90 Inhibitor.
Discovery of 5-aryl-3-thiophen-2-yl-1H-pyrazoles as a new class of Hsp90 inhibitors in hepatocellular carcinoma.
Discovery of a covalent inhibitor of heat shock protein 90 with antitumor activity that blocks the co-chaperone binding via C-terminal modification.
Discovery of a Potent Grp94 Selective Inhibitor with Anti-Inflammatory Efficacy in a Mouse Model of Ulcerative Colitis.
Discovery of a stable macrocyclic o-aminobenzamide Hsp90 inhibitor which significantly decreases tumor volume in a mouse xenograft model.
Discovery of aminoquinolines as a new class of potent inhibitors of heat shock protein 90 (Hsp90): Synthesis, biology, and molecular modeling.
Discovery of benzisoxazoles as potent inhibitors of chaperone heat shock protein 90.
Discovery of hybrid Hsp90 inhibitors and their anti-neoplastic effects against gefitinib-resistant non-small cell lung cancer (NSCLC).
Discovery of new heat shock protein 90 inhibitors using virtual co-crystallized pharmacophore generation.
Discovery of new molecular entities able to strongly interfere with Hsp90 C-terminal domain.
Discovery of NMS-E973 as novel, selective and potent inhibitor of heat shock protein 90 (Hsp90).
Discovery of novel 2-aminobenzamide inhibitors of heat shock protein 90 as potent, selective and orally active antitumor agents.
Discovery of novel anti-breast cancer agents derived from deguelin as inhibitors of heat shock protein 90 (HSP90).
Discovery of novel Hsp90 C-terminal domain inhibitors that disrupt co-chaperone binding.
Discovery of Novel Hsp90 C-Terminal Inhibitors Using 3D-Pharmacophores Derived from Molecular Dynamics Simulations.
Discovery of novel NO-releasing celastrol derivatives with Hsp90 inhibition and cytotoxic activities.
Discovery of pentapeptide-inhibitor hits targeting FKBP51 by combining computational modeling and X-ray crystallography.
Discovery of potent N-(isoxazol-5-yl)amides as HSP90 inhibitors.
Discovery of small molecules targeting GRP78 for antiangiogenic and anticancer therapy.
Discovery of structure-based small molecular inhibitor of ?B-crystallin against basal-like/triple-negative breast cancer development in vitro and in vivo.
Disruption of hsp90 function results in degradation of the death domain kinase, receptor-interacting protein (RIP), and blockage of tumor necrosis factor-induced nuclear factor-kappaB activation.
Disruption of HSP90 function reverts tumor necrosis factor-induced necrosis to apoptosis.
Distal intestinal gene expression in Atlantic salmon (Salmo salar L.) fed genetically modified maize
Distinct regulation of insulin receptor substrate-1 and -2 by 90-kDa heat-shock protein in adrenal chromaffin cells.
Divergent effects of castration on prostate cancer in TRAMP mice: possible implications for therapy.
DNA nanotechnology-based composite-type gold nanoparticle-immunostimulatory DNA hydrogel for tumor photothermal immunotherapy.
DNA vaccine encoding heat shock protein 60 co-linked to HPV16 E6 and E7 tumor antigens generates more potent immunotherapeutic effects than respective E6 or E7 tumor antigens.
DNA-templated porous nanoplatform towards programmed "double-hit" cancer therapy via hyperthermia and immunogenicity activation.
Dnajb8, a Member of the Heat Shock Protein 40 Family Has a Role in the Tumor Initiation and Resistance to Docetaxel but Is Dispensable for Stress Response.
Docosahexaenoic acid in combination with celecoxib modulates HSP70 and p53 proteins in prostate cancer cells.
Docosahexaenoic Acid-mediated Inhibition of Heat Shock Protein 90-p23 Chaperone Complex and Downstream Client Proteins in Lung and Breast Cancer.
Does the compromised sleep and circadian disruption of night and shiftworkers make them highly vulnerable to 2019 coronavirus disease (COVID-19)?
Dorsomorphin induces cancer cell apoptosis and sensitizes cancer cells to HSP90 and proteasome inhibitors by reducing nuclear heat shock factor 1 levels.
Dose-escalation study of a second-generation non-ansamycin HSP90 inhibitor, onalespib (AT13387), in combination with imatinib in patients with metastatic gastrointestinal stromal tumour.
Down-regulation of GRP78 is associated with the sensitivity of chemotherapy to VP-16 in small cell lung cancer NCI-H446 cells.
Down-regulation of HSP40 gene family following OCT4B1 suppression in human tumor cell lines.
Down-regulation of Hsp90 could change cell cycle distribution and increase drug sensitivity of tumor cells.
Down-regulation of topoisomerase II alpha is caused by up-regulation of GRP78.
Downregulation of HSP60 disrupts mitochondrial proteostasis to promote tumorigenesis and progression in clear cell renal cell carcinoma.
Doxorubicin anti-tumor mechanisms include Hsp60 post-translational modifications leading to the Hsp60/p53 complex dissociation and instauration of replicative senescence.
Dried lemon peel enriched diet improves antioxidant activity, immune response and modulates immuno-antioxidant genes in Labeo rohita against Aeromonas sorbia.
Drug design, synthesis and in vitro evaluation of substituted benzofurans as Hsp90 inhibitors.
Drug evaluation: STA-4783--enhancing taxane efficacy by induction of Hsp70.
Drug-Like Small Molecule HSP27 Functional Inhibitor Sensitizes Lung Cancer Cells to Gefitinib or Cisplatin by Inducing Altered Cross-Linked Hsp27 Dimers.
Drug-mediated targeted disruption of multiple protein activities through functional inhibition of the Hsp90 chaperone complex.
Druggability of Mortalin for Cancer and Neuro-Degenerative Disorders.
Drugging the cancer chaperone HSP90: combinatorial therapeutic exploitation of oncogene addiction and tumor stress.
DT-Diaphorase expression and tumor cell sensitivity to 17-allylamino, 17-demethoxygeldanamycin, an inhibitor of heat shock protein 90.
Dual Binding to Orthosteric and Allosteric Sites Enhances the Anticancer Activity of a TRAP1-Targeting Drug.
Dual drug-paired polyprodrug nanotheranostics reverse multidrug resistant cancers via mild photothermal-cocktail chemotherapy.
Dual function of membrane-bound heat shock protein 70 (Hsp70), Bag-4, and Hsp40: protection against radiation-induced effects and target structure for natural killer cells.
Dual inhibition of chaperoning process by taxifolin: molecular dynamics simulation study.
Dual mode of cancer cell destruction for pancreatic cancer therapy using Hsp90 inhibitor loaded polymeric nano magnetic formulation.
Dual PI3K- and mTOR-inhibitor PI-103 can either enhance or reduce the radiosensitizing effect of the Hsp90 inhibitor NVP-AUY922 in tumor cells: The role of drug-irradiation schedule.
Dual role of heat shock proteins as regulators of apoptosis and innate immunity.
Dual systemic tumor targeting with ligand-directed phage and Grp78 promoter induces tumor regression.
Dual targeting of HSC70 and HSP72 inhibits HSP90 function and induces tumor-specific apoptosis.
Dual targeting of HSP70 does not induce the heat shock response and synergistically reduces cell viability in muscle invasive bladder cancer.
Dual Targeting Strategies On Histone Deacetylase 6 (HDAC6) And Heat Shock Protein 90 (Hsp90).
Dual-Channel Theranostic System for Quantitative Self-Indication and Low-Temperature Synergistic Therapy of Cancer.
Dual-targeting of mTOR and HSP90 for cancer therapy: Facing oncogenic feed-back-loops and acquired mTOR resistance.
Dynamic changes in gene expression during vitellogenic stages of the white shrimp: Fenneropenaeus merguiensis de Man
Dynamic effect of heat shock pretreatment on apoptotic responses to TNF-alpha in liver cells.
Dynamic impacts of the inhibition of the molecular chaperone Hsp90 on the T-cell proteome have implications for anti-cancer therapy.
Dynamic proteomics reveals bimodal protein dynamics of cancer cells in response to HSP90 inhibitor.
Dynamically Shaping Chaperones. Allosteric Modulators of HSP90 Family as Regulatory Tools of Cell Metabolism in Neoplastic Progression.
Dynamics-Based Discovery of Allosteric Inhibitors: Selection of New Ligands for the C-terminal Domain of Hsp90.
E3 ubiquitin ligase Cullin-5 modulates multiple molecular and cellular responses to heat shock protein 90 inhibition in human cancer cells.
Early and Synergistic Recovery Effect of Herbal Combination on Surgically Corrected Varicocele.
Early cytotoxic effects of ochratoxin A in rat liver: a morphological, biochemical and molecular study.
Early development of PAT-SM6 for the treatment of melanoma.
Early tumor response to Hsp90 therapy using HER2 PET: comparison with 18F-FDG PET.
EC144, a synthetic inhibitor of heat shock protein 90, blocks innate and adaptive immune responses in models of inflammation and autoimmunity.
Effect of antiangiogenic therapy on luciferase activity in a cytomegalovirus- or HSP70-promoter-transfected M21 tumor model.
Effect of glutamate on lysosomal membrane permeabilization in primary cultured cortical neurons.
Effect of heat shock on susceptibility of normal lymphoblasts and of a heat shock protein 70-defective tumour cell line to cytotoxic T lymphocytes in vitro.
Effect of heat shock protein 90 (Hsp90) on migration and invasion of human cancer cells in vitro.
Effect of heat stress on LPS-induced febrile response in D-galactosamine-sensitized rats.
Effect of heat-shock protein-90 (HSP90) inhibition on human hepatocytes and on liver regeneration in experimental models.
Effect of HSP90AB1 and CC domain interaction on Bcr-Abl protein cytoplasm localization and function in chronic myeloid leukemia cells.
Effect of hyperthermic CO2-treated dendritic cell-derived exosomes on the human gastric cancer AGS cell line.
Effect of inhibitors of poly(ADP-ribose) polymerase on the induction of GRP78 and subsequent development of resistance to etoposide.
Effect of novobiocin on the viability of human gingival fibroblasts (HGF-1).
Effect of overexpression of glucose-regulated protein 78 and bcl-2 on recurrence and survival in patients with ureter tumors.
Effect of overexpression of the small heat shock protein HSP27 on the heat and drug sensitivities of human testis tumor cells.
Effect of Polysaccharides from Acanthopanax senticosus on Intestinal Mucosal Barrier of Escherichia coli Lipopolysaccharide Challenged Mice.
Effect of S-adenosylmethionine on neointimal formation after balloon injury in obese diabetic rats.
Effect of social housing condition on heat shock protein (HSP) expression in the Shionogi mouse mammary carcinoma (SC115).
Effectiveness of hsp90 inhibitors as anti-cancer drugs.
Effects of a heat shock protein inhibitor KNK437 on heat sensitivity and heat tolerance in human squamous cell carcinoma cell lines differing in p53 status.
Effects of acupuncture at Baihui (DU20) and Zusanli (ST36) on the expression of heat shock protein 70 and tumor necrosis factor ? in the peripheral serum of cerebral ischemia-reperfusion-injured rats.
Effects of antimicrobial peptides on serum biochemical parameters, antioxidant activity and non-specific immune responses in Epinephelus coioides.
Effects of Bacillus subtilis WB60 and Lactococcus lactis on Growth, Immune Responses, Histology and Gene Expression in Nile tilapia, Oreochromis niloticus.
Effects of chito-oligosaccharides supplementation on growth performance, intestinal cytokine expression, autochthonous gut bacteria and disease resistance in hybrid tilapia Oreochromis niloticus ? × Oreochromis aureus ?.
Effects of chronic nitrate exposure on the intestinal morphology, immune status, barrier function, and microbiota of juvenile turbot (Scophthalmus maximus).
Effects of ciprofloxacin exposure on the earthworm Eisenia fetida.
Effects of combination of melatonin and laser irradiation on ovarian cancer cells and endothelial lineage viability.
Effects of dietary Allium mongolicum Regel polysaccharide on growth, lipopolysaccharide-induced antioxidant responses and immune responses in Channa argus.
Effects of dietary anthocyanin on innate immune parameters, gene expression responses, and ammonia resistance of Nile tilapia (Oreochromis niloticus).
Effects of dietary manipulation on compensatory growth of juvenile genetically improved farmed tilapia (Oreochromis niloticus).
Effects of dietary monoterpene, myrcene, administration on immune- and health-related genes expression in common carp gill following exposure to copper sulfate.
Effects of Ergosan on the expression of cytokine genes in the liver of juvenile rainbow trout (Oncorhynchus mykiss) exposed to enteric red mouth vaccine.
Effects of glutamine supplementation on muscle function and stress responses in a mouse model of spinal cord injury.
Effects of heat stress on the level of heat shock protein 70 on the surface of hepatocellular carcinoma Hep G2 cells: implications for the treatment of tumors.
Effects of HSP70 on the compression force-induced TNF-? and RANKL expression in human periodontal ligament cells.
Effects of Hsp90 inhibition in neuroblastoma: analysis of drug sensitivity, target modulation and the influence of bone marrow microenvironment.
Effects of HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin (17-AAG) on NEU/HER2 overexpressing mammary tumours in MMTV-NEU-NT mice monitored by Magnetic Resonance Spectroscopy.
Effects of Hsp90 inhibitor on the RIP1-RIP3-MLKL pathway during the development of heart failure in mice.
Effects of Molybdenum or/and Cadmium on mRNA Expression Levels of Inflammatory Cytokines and HSPs in Duck Spleens.
Effects of nontoxic heat shock protein 90 inhibitor peptide derivatives on reversal of MDR of tumor cells.
Effects of Prolonged GRP78 Haploinsufficiency on Organ Homeostasis, Behavior, Cancer and Chemotoxic Resistance in Aged Mice.
Effects of quercetin and sunphenon on responses of cancer cells to heat shock damage.
Effects of Resistance Training at Different Loads on Inflammatory Biomarkers, Muscle Mass, Muscular Strength, and Physical Performance in Postmenopausal Women.
Effects of retinoic acid on the expression of a tumor rejection antigen (heat shock protein gp96) in human cervical cancer.
Effects of the antimicrobial peptide LL-37 and hyperthermic preconditioning in septic rats.
Effects of treatment with an Hsp90 inhibitor in tumors based on 15 phase II clinical trials.
Efficacy and safety of TAS-116, an oral inhibitor of heat shock protein 90, in patients with metastatic or unresectable gastrointestinal stromal tumour refractory to imatinib, sunitinib and regorafenib: a phase II, single-arm trial.
Efficacy of an EGFR-Specific Peptide against EGFR-Dependent Cancer Cell Lines and Tumor Xenografts.
Efficacy of an HSP90 inhibitor, ganetespib, in preclinical thyroid cancer models.
Efficacy of Hsp90 inhibition for induction of apoptosis and inhibition of growth in cervical carcinoma cells in vitro and in vivo.
Efficiency of G2/M-related tumor-associated antigen-targeting cancer immunotherapy depends on antigen expression in the cancer stem-like population.
Elaborate ligand-based modeling reveals new nanomolar heat shock protein 90? inhibitors.
Elaiophylin Is a Potent Hsp90/ Cdc37 Protein Interface Inhibitor with K-Ras Nanocluster Selectivity.
Elevated concentrations of the small stress protein HSP27 in rat renal tumors.
Elevated expression of nuclear Hsp90 in invasive breast tumors.
Elevated GRP78 expression is associated with poor prognosis in patients with pancreatic cancer.
Elevated levels of HSF1 indicate a poor prognosis in breast cancer.
Elevated levels of mitochondrial mortalin and cytosolic HSP70 in blood as risk factors in patients with colorectal cancer.
Elevated levels of mortalin expression in human brain tumors.
Elevated Mortalin correlates with poor outcome in hepatocellular carcinoma.
Elevated risks for amyotrophic lateral sclerosis and blood disorders in Ashkenazi schizophrenic pedigrees suggest new candidate genes in schizophrenia.
Elevated serum levels of heat shock protein 70 can be detected after radiofrequency ablation.
Elimination of head and neck cancer initiating cells through targeting glucose regulated protein78 signaling.
Elucidation of antiangiogenic potential of Vitexin obtained from Cucumis sativus targeting Hsp90 protein: A novel multipathway targeted approach to restrain angiogenic phenomena.
Emergence of resistance to tyrosine kinase inhibitors in non-small-cell lung cancer can be delayed by an upfront combination with the HSP90 inhibitor onalespib.
Emerging Hsp90 inhibitors: from discovery to clinic.
Emerging Roles of Extracellular Hsp90 in Cancer.
Emerging roles of HSF1 in cancer: Cellular and molecular episodes.
Emphasizing on heat shock protein 90's utility in head and neck squamous cell carcinoma treatment.
Endocytosis and sorting of ErbB2 and the site of action of cancer therapeutics trastuzumab and geldanamycin.
Endogenous membrane tumor necrosis factor (TNF) is a potent amplifier of TNF receptor 1-mediated apoptosis.
Endogenous tumor necrosis factor promotes resistance to cellular stresses by inducing the metallothionein-1A gene.
Endogenous tumour necrosis factor regulates heat-inducible heat shock protein 72 synthesis.
Endoplasmic reticulum chaperone glucose regulated protein 170-Pokemon complexes elicit a robust antitumor immune response in vivo.
Endoplasmic reticulum chaperone glucose-regulated protein 78 in gastric cancer: An emerging biomarker.
Endoplasmic reticulum chaperone GRP78/BiP is critical for mutant Kras-driven lung tumorigenesis.
Endoplasmic reticulum heat shock protein gp96/grp94 is a pro-oncogenic chaperone, not a tumor suppressor.
Endoplasmic reticulum ribosome-binding protein 1 (RRBP1) overexpression is frequently found in lung cancer patients and alleviates intracellular stress-induced apoptosis through the enhancement of GRP78.
Endoplasmic reticulum stress as a correlate of cytotoxicity in human tumor cells exposed to diindolylmethane in vitro.
Endoplasmic reticulum stress confers 5-fluorouracil resistance in breast cancer cell via the GRP78/OCT4/lncRNA MIAT/AKT pathway.
Endoplasmic reticulum stress is activated in endometrial adenocarcinoma.
Endoplasmic Reticulum-resident Heat Shock Protein 90 (HSP90) Isoform Glucose-regulated Protein 94 (GRP94) Regulates Cell Polarity and Cancer Cell Migration by Affecting Intracellular Transport.
Endotoxin contamination in recombinant human heat shock protein 70 (Hsp70) preparation is responsible for the induction of tumor necrosis factor alpha release by murine macrophages.
Engineered production of kitasetalic acid, a new tetrahydro-?-carboline with the ability to suppress glucose-regulated protein synthesis.
Engineered Tumor-Derived Extracellular Vesicles: Potentials in Cancer Immunotherapy.
Engineering an antibiotic to fight cancer: optimization of the novobiocin scaffold to produce anti-proliferative agents.
Enhanced antitumor activity of erlotinib in combination with the Hsp90 inhibitor CH5164840 against non-small-cell lung cancer.
Enhanced antitumor immunity of nanoliposome-encapsulated heat shock protein 70 peptide complex derived from dendritic tumor fusion cells.
Enhanced cell killing induced by the combination of radiation and the heat shock protein 90 inhibitor 17-allylamino-17- demethoxygeldanamycin: a multitarget approach to radiosensitization.
Enhanced immunogenicity of heat shock protein 70 peptide complexes from dendritic cell-tumor fusion cells.
Enhanced in vivo antitumor efficacy of dual-functional peptide-modified docetaxel nanoparticles through tumor targeting and Hsp90 inhibition.
Enhanced sensitivity to mitomycin C by abating heat shock protein 70 expression in human bladder cancer cell line of BIU-87.
Enhanced suicide gene therapy by chimeric tumor-specific promoter based on HSF1 transcriptional regulation.
Enhanced Susceptibility to 5-Fluorouracil in Human Colon Cancer Cells by Silencing of GRP78.
Enhanced synergism of thermo-chemotherapy by combining highly efficient magnetic hyperthermia with magnetothermally-facilitated drug release.
Enhanced T-cell immunity induced by dendritic cells with phagocytosis of heat shock protein 70 gene-transfected tumor cells in early phase of apoptosis.
Enhanced tumor cell radiosensitivity and abrogation of G2 and S phase arrest by the Hsp90 inhibitor 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin.
Enhanced ubiquitinylation of heat shock protein 90 as a potential mechanism for mitotic cell death in cancer cells induced with hypericin.
Enhancement of complement-induced cell lysis: a novel mechanism for the anticancer effects of Hsp90 inhibitors.
Enhancement of tumor-specific T cell-mediated immunity in dendritic cell-based vaccines by Mycobacterium tuberculosis heat shock protein X.
Enhancing HSP70-ShRNA transfection in 22RV1 prostate cancer cells by combination of sonoporation, liposomes and HTERT/CMV chimeric promoter.
Enhancing therapeutic HPV DNA vaccine potency through depletion of CD4+CD25+ T regulatory cells.
Environmental stress and genes of hypertension.
Epigallocatechin-3-gallate suppresses the expression of HSP70 and HSP90 and exhibits anti-tumor activity in vitro and in vivo.
Epithelial-to-mesenchymal transition: immunohistochemical investigation of related molecules in canine cutaneous epithelial tumours.
ER stress sensor, glucose regulatory protein 78 (GRP78) regulates redox status in pancreatic cancer thereby maintaining "stemness".
ER Translocation of the MAPK Pathway Drives Therapy Resistance in BRAF-Mutant Melanoma.
Eradication of glioblastoma, and breast and colon carcinoma xenografts by Hsp70 depletion.
Eradication of murine mammary adenocarcinoma through HSVtk expression directed by the glucose-starvation inducible grp78 promoter.
ErbB3 expression predicts tumor cell radiosensitization induced by Hsp90 inhibition.
Ergothioneine modulates proinflammatory cytokines and heat shock protein 70 in mesenteric ischemia and reperfusion injury.
ERK-dependent phosphorylation of the linker and substrate-binding domain of HSP70 increases folding activity and cell proliferation.
ERK-regulated ?B-crystallin induction by matrix detachment inhibits anoikis and promotes lung metastasis in vivo.
ERO1?-dependent endoplasmic reticulum-mitochondrial calcium flux contributes to ER stress and mitochondrial permeabilization by procaspase-activating compound-1 (PAC-1).
Erratum to: Novel C-terminal Hsp90 Inhibitor for Head and Neck Squamous Cell Cancer (HNSCC) with in vivo Efficacy and Improved Toxicity Profiles Compared with Standard Agents.
Erratum: Heat shock protein 70-2 (HSP70-2) a novel cancer testis antigen that promotes growth of ovarian cancer.
Erythroid Differentiation Regulator 1, an Interleukin 18-Regulated Gene, Acts as a Metastasis Suppressor in Melanoma.
Erythropoietin prevents the effect of chronic restraint stress on the number of hippocampal CA3c dendritic terminals-relation to expression of genes involved in synaptic plasticity, angiogenesis, inflammation, and oxidative stress in male rats.
Erythropoietin receptors on tumor cells: what do they mean?
Essential oil from Cymbopogon flexuosus as the potential inhibitor for HSP90.
Establish an automated flow injection ESI-MS method for the screening of fragment based libraries: Application to Hsp90.
Establishment of a spontaneous metastasis tumor model for human ErbB-2 vaccine.
Estrogen receptor gene expression and its relation to the estrogen-inducible HSP27 heat shock protein in hormone refractory prostate cancer.
Estrogen receptor, progesterone receptor, and HER-2/neu protein in breast cancers from pregnant patients.
Estrogen receptor-?36-mediated rapid estrogen signaling regulates 78 kDa glucose-regulated protein expression in gastric carcinoma cells.
Estrogen-induced genes in the uterus of ovariectomized rats and their regulation by droloxifene and tamoxifen.
Ethnic differences of polymorphisms in cytokine and innate immune system genes in pregnant women.
Etoposide-resistant HT-29 human colon carcinoma cells during glucose deprivation are sensitive to piericidin A, a GRP78 down-regulator.
Evaluation of 8-arylsulfanyl, 8-arylsulfoxyl, and 8-arylsulfonyl adenine derivatives as inhibitors of the heat shock protein 90.
Evaluation of anti-tumor effects of tumor cell lysate enriched by HSP-70 against fibrosarcoma tumor in BALB/c mice.
Evaluation of Hsp90 and mTOR inhibitors as potential drugs for the treatment of TSC1/TSC2 deficient cancer.
Evaluation of renal cell carcinoma vaccines targeting carbonic anhydrase IX using heat shock protein 110.
Evaluation of the Hsp90 inhibitor NVP-AUY922 in multicellular tumour spheroids with respect to effects on growth and PET tracer uptake.
Evaluation of the radiosensitizing potency of chemotherapeutic agents in prostate cancer cells.
Evaluation of [11C]NMS-E973 as a PET tracer for in vivo visualisation of HSP90.
Evidence for efficacy of new Hsp90 inhibitors revealed by ex vivo culture of human prostate tumors.
Evidence of a Cell Surface Role for Hsp90 Complex Proteins Mediating Neuroblast Migration in the Subventricular Zone.
Evidence of prognostic relevant expression profiles of heat-shock proteins and glucose-regulated proteins in oesophageal adenocarcinomas.
Evodiamine inhibits both stem cell and non-stem-cell populations in human cancer cells by targeting heat shock protein 70.
Evolutionarily conserved dual lysine motif determines the non-chaperone function of secreted Hsp90alpha in tumour progression.
Ex vivo Hsp70-Activated NK Cells in Combination With PD-1 Inhibition Significantly Increase Overall Survival in Preclinical Models of Glioblastoma and Lung Cancer.
Exercise Training Attenuates Neuropathic Pain and Cytokine Expression After Chronic Constriction Injury of Rat Sciatic Nerve.
Exercise, vascular wall and cardiovascular diseases: an update (Part 1).
Exogenous heat shock cognate protein 70 pretreatment attenuates cardiac and hepatic dysfunction with associated anti-inflammatory responses in experimental septic shock.
Exogenous heat shock protein 27 uniquely blocks differentiation of monocytes to dendritic cells.
Exogenous hydrogen sulfide exerts proliferation, anti-apoptosis, angiopoiesis and migration effects via activating HSP90 pathway in EC109 cells.
Exogenous stress proteins enhance the immunogenicity of apoptotic tumor cells and stimulate antitumor immunity.
Exogenously delivered heat shock protein 70 displaces its endogenous analogue and sensitizes cancer cells to lymphocytes-mediated cytotoxicity.
Exosomal formulation enhances therapeutic response of celastrol against lung cancer.
Exosomal HSP60: a potentially useful biomarker for diagnosis, assessing prognosis, and monitoring response to treatment.
Exosomes Based Geldanamycin Delivery to Cancer Cells with Increased Therapeutic Efficacy.
Exosomes derived from siRNA against GRP78 modified bone-marrow-derived mesenchymal stem cells suppress Sorafenib resistance in hepatocellular carcinoma.
Exosomes from heat-stressed tumour cells inhibit tumour growth by converting regulatory T cells to Th17 cells via IL-6.
Exosomes released by breast cancer cells under mild hyperthermic stress possess immunogenic potential and modulate polarization in vitro in macrophages.
Expansion of protein interaction maps by phage peptide display using MDM2 as a prototypical conformationally flexible target protein.
Experimentally guided structural modeling and dynamics analysis of Hsp90-p53 interactions: allosteric regulation of the Hsp90 chaperone by a client protein.
Exploiting cancer cell vulnerabilities to develop a combination therapy for ras-driven tumors.
Exploiting polarity and chirality to probe the Hsp90 C-terminus.
Exploiting the HSP60/10 chaperonin system as a chemotherapeutic target for colorectal cancer.
Exploiting the mitochondrial unfolded protein response for cancer therapy in mice and human cells.
Exploiting vulnerabilities in cancer signalling networks to combat targeted therapy resistance.
Exploration of Benzothiazole Rhodacyanines as Allosteric Inhibitors of Protein-Protein Interactions with Heat Shock Protein 70 (Hsp70).
Exploring weak ligand-protein interactions by long-lived NMR states: improved contrast in fragment-based drug screening.
Exposure of Wistar rats to 24-h psycho-social stress alters gene expression in the inferior colliculus.
Express ELISA for detection of mortalin.
Expression analysis of heat shock protein 90 (HSP90) and Her2 in colon carcinoma.
Expression and clinical significance of glucose regulated proteins GRP78 (BiP) and GRP94 (GP96) in human adenocarcinomas of the esophagus.
Expression and localization of GRP75 in human epithelial tumors and normal tissues.
Expression and purification of recombinant NRL-Hsp90? and Cdc37-CRL proteins for in vitro Hsp90/Cdc37 inhibitors screening.
Expression and roles of heat shock proteins in human breast cancer.
Expression and significance of glucose-regulated protein 78 in human osteosarcoma.
Expression and therapeutic relevance of heat shock protein 90 in pancreatic endocrine tumors.
Expression levels of heat shock protein 20 decrease in parallel with tumor progression in patients with hepatocellular carcinoma.
Expression of ?B-crystallin and its potential anti-apoptotic role in oral verrucous carcinoma.
Expression of a defective mouse mammary tumor virus envelope glycoprotein precursor which binds stably to GRP78 within the lumen of the endoplasmic reticulum is associated with decreased glucocorticoid-induced apoptosis in mouse lymphoma cells.
Expression of a small heat shock protein 27 (HSP27) in mouse skin tumors induced by UVB-irradiation.
Expression of a unique drug-resistant Hsp90 ortholog by the nematode Caenorhabditis elegans.
Expression of Anti-apoptotic Protein BAG3 in Human Sebaceous Gland Carcinoma of the Eyelid.
Expression of Antioxidant Molecules and Heat Shock Protein 27 in Thyroid Tumors.
Expression of chemoresistance-related genes and heat shock protein 72 in hyperthermic isolated limb perfusion of malignant melanoma: an experimental study.
Expression of CRYAB with the angiogenesis and poor prognosis for human gastric cancer.
Expression of endoplasmic reticulum molecular chaperone Grp78 in human lung cancer and its clinical significance.
Expression of ER stress and autophagy-related molecules in human non-small cell lung cancer and premalignant lesions.
Expression of ER stress markers (GRP78/BiP and PERK) in adenoid cystic carcinoma.
Expression of ERp5 and GRP78 on the membrane of chronic lymphocytic leukemia cells: association with soluble MICA shedding.
Expression of focal adhesion kinase in uveal melanoma and the effects of Hsp90 inhibition by 17-AAG.
Expression of gene-specific RNA in cultured cells exposed to rotating 60-Hz magnetic fields.
Expression of glucose regulated protein 78 (GRP78) determines colorectal cancer response to chemotherapy.
Expression of glucose-regulated stress protein GRP78 is related to progression of melanoma.
Expression of GRP78 predicts taxane-based therapeutic resistance and recurrence of human gastric cancer.
Expression of Heat Shock Protein 105 in Cutaneous Squamous Cell Carcinoma: Correlation with Clinicopathological Characteristics.
Expression of heat shock protein 20 inversely correlated with tumor progression in patients with ovarian cancer.
Expression of heat shock protein 27 in prostate cancer cell lines according to the extent of malignancy and doxazosin treatment.
Expression of heat shock protein 47 in the fibrous tissue adjacent to mouse tumour subjected to photodynamic therapy.
Expression of heat shock protein 70 (HSP70) in patients with colorectal adenocarcinoma--immunohistochemistry and Western blot analysis.
Expression of heat shock protein 70 in nasopharyngeal carcinomas: different expression patterns correlate with distinct clinical prognosis.
Expression of heat shock protein 70 in renal cell carcinoma and its relation to tumor progression and prognosis.
Expression of heat shock protein 72 in renal cell carcinoma: possible role and prognostic implications in cancer patients.
Expression of heat shock protein 90 at the cell surface in human neuroblastoma cells.
Expression of heat shock protein 90 beta in human gastric cancer tissue and SGC7901/VCR of MDR-type gastric cancer cell line.
Expression of heat shock proteins and heat shock protein messenger ribonucleic acid in human prostate carcinoma in vitro and in tumors in vivo.
Expression of heat shock proteins HSP70 and HSP90 in endometrial carcinomas. Correlation with clinicopathology, sex steroid receptor status, and p53 protein expression.
Expression of heat shock proteins in premalignant and malignant urothelial lesions of bovine urinary bladder.
Expression of heat shock proteins in squamous cell carcinoma of the tongue: an immunohistochemical study.
Expression of heat-shock protein-90 in non-Hodgkin's lymphomas.
Expression of heat-shock proteins hsp27, hsp70 and hsp90 in malignant epithelial tumour of the ovaries.
Expression of HSP27, HSP72 and MRP proteins in in vitro co-culture of colon tumour cell spheroids with normal cells after incubation with rhTGF- beta1 and/or CPT-11.
Expression of hsp90 and cyclin D1 in human breast cancer.
Expression of Hsp90 chaperome proteins in human tumor tissue.
Expression of HSP90 in gastrointestinal stromal tumours and mesenchymal tumours.
Expression of major heat shock proteins in prostate cancer: correlation with clinicopathological outcomes in patients undergoing radical prostatectomy.
Expression of mortalin detected in human liver cancer by tissue microarrays.
Expression of mutant protein p53 and Hsp70 and Hsp90 chaperones in cockles Cerastoderma edule affected by neoplasia.
Expression of novel tumor markers of pancreatic adenocarcinomas in intrahepatic cholangiocarcinomas.
Expression of P53 and HSP70 in Chronic Hepatitis, Liver Cirrhosis, and Early and Advanced Hepatocellular Carcinoma Tissues and Their Diagnostic Value in Hepatocellular Carcinoma: An Immunohistochemical Study.
Expression of p53, bcl-2 and heat shock protein (hsp72) in malignant and benign ovarian tumours.
Expression of stress response protein glucose regulated protein-78 mediated by c-Myb.
Expression of stress response protein Grp78 is associated with the development of castration-resistant prostate cancer.
Expression of the 27-kDa heat shock protein in human epidermis and in epidermal neoplasms: an immunohistological study.
Expression of the CD117, COX-2 and HSP90 antigens and cell proliferation in fine-needle-aspirated cells from metastatic melanomas.
Expression of the heat shock cognate protein HSP73 correlates with tumour thickness of primary melanomas and is enhanced in melanoma metastases.
Expression of the heat shock protein HSP27 in human ovarian cancer.
Expression of the molecular chaperone ?B-crystallin in infiltrating ductal breast carcinomas and the significance thereof: an immunohistochemical and proteomics-based strategy.
Expression of the small heat shock protein (hsp) 27 in human astrocytomas correlates with histologic grades and tumor growth fractions.
Expression of tumor antigens and heat-shock protein 70 in breast cancer cells after high-intensity focused ultrasound ablation.
Expression pattern of heat shock protein 90 in patients with oral squamous cell carcinoma in northern Taiwan.
Expression patterns of Trk-A, Trk-B, GRP78, and p75NRT in olfactory neuroblastoma.
Expression Profile of Genes Associated with the Proteins Degradation Pathways in Colorectal adenocarcinoma.
Expression profile of the telomeric complex discriminates between benign and malignant pheochromocytoma.
Expression profiling of small intestinal neuroendocrine tumors identifies subgroups with clinical relevance, prognostic markers and therapeutic targets.
Expressions of GRP78 and Bax associate with differentiation, metastasis, and apoptosis in non-small cell lung cancer.
Extracellular 70-kd heat shock protein in mid-trimester amniotic fluid and its effect on cytokine production by ex vivo-cultured amniotic fluid cells.
Extracellular heat shock protein 70 inhibits tumour necrosis factor-alpha induced proinflammatory mediator production in fibroblast-like synoviocytes.
Extracellular heat shock protein 90: a role for a molecular chaperone in cell motility and cancer metastasis.
Extracellular Hsp70 Reduces the Pro-Tumor Capacity of Monocytes/Macrophages Co-Cultivated with Cancer Cells.
Extracellular HSP70-peptide complexes promote the proliferation of hepatocellular carcinoma cells via TLR2/4/JNK1/2MAPK pathway.
Extracellular HSP70/HSP70-PCs promote epithelial-mesenchymal transition of hepatocarcinoma cells.
Extracellular Hsp90 (eHsp90) as the Actual Target in Clinical Trials: Intentionally or Unintentionally.
Extracellular Hsp90 mediates an NF-?B dependent inflammatory stromal program: implications for the prostate tumor microenvironment.
Extracellular Hsp90 serves as a co-factor for MAPK activation and latent viral gene expression during de novo infection by KSHV.
Extracellular Hsp90 serves as a co-factor for NF-?B activation and cellular pathogenesis induced by an oncogenic herpesvirus.
Extracellular HSP90: conquering the cell surface.
Extracellular Hsp90? and clusterin synergistically promote breast cancer epithelial-to-mesenchymal transition and metastasis via LRP1.
Extracellular roles for the molecular chaperone, hsp90.
Extracellular targeting of endoplasmic reticulum chaperone glucose-regulated protein 170 enhances tumor immunity to a poorly immunogenic melanoma.
Extracellular Vesicle Subtypes Released From Activated or Apoptotic T-Lymphocytes Carry a Specific and Stimulus-Dependent Protein Cargo.
Extreme winter cold-induced osmoregulatory, metabolic, and physiological responses in European seabass (Dicentrarchus labrax) acclimatized at different salinities.
F1F0-ATP synthase functions as a co-chaperone of Hsp90-substrate protein complexes.
Fabrication of Electrochemical Biosensor Based on Titanium Dioxide Nanotubes and Silver Nanoparticles for Heat Shock Protein 70 Detection.
Fas ligation and tumor necrosis factor ? activation of murine astrocytes promote heat shock factor-1 activation and heat shock protein expression leading to chemokine induction and cell survival.
Fatty Acid Oxidation Is an Adaptive Survival Pathway Induced in Prostate Tumors by HSP90 Inhibition.
FBW7-Dependent Mcl-1 Degradation Mediates the Anticancer Effect of Hsp90 Inhibitors.
Fe3 O4 nanoparticles mediated synthesis of novel spirooxindole-dihydropyrimidinone molecules as Hsp90 inhibitors.
Features of the Streptomyces hygroscopicus HtpG reveal how partial geldanamycin resistance can arise with mutation to the ATP binding pocket of a eukaryotic Hsp90.
Feeding a Saccharomyces cerevisiae fermentation product improves udder health and immune response to a Streptococcus uberis mastitis challenge in mid-lactation dairy cows.
Fever-range hyperthermia vs. hypothermia effect on cancer cell viability, proliferation and HSP90 expression.
First Structural View of a Peptide Interacting with the Nucleotide Binding Domain of Heat Shock Protein 90.
First-in-human phase I dose escalation study of a second-generation non-ansamycin HSP90 inhibitor, AT13387, in patients with advanced solid tumors.
First-in-human phase I dose-escalation study of the HSP90 inhibitor AUY922 in patients with advanced solid tumors.
First-in-Human Phase I Study of an Oral HSP90 Inhibitor, TAS-116, in Patients with Advanced Solid Tumors.
First-in-human study of the epichaperome inhibitor PU-H71: clinical results and metabolic profile.
FKBP51 promotes assembly of the Hsp90 chaperone complex and regulates androgen receptor signaling in prostate cancer cells.
Flavones and flavonols may have clinical potential as CK2 inhibitors in cancer therapy.
Flower-like gold nanoparticles for enhanced photothermal anticancer therapy by the delivery of pooled siRNA to inhibit heat shock stress response.
Fluorine- and rhenium-containing geldanamycin derivatives as leads for the development of molecular probes for imaging Hsp90.
Fluoropyrimidin-2,4-dihydroxy-5-isopropylbenzamides as antitumor agents against CRC and NSCLC cancer cells.
Folate receptor-targeted hybrid lipid-core nanocapsules for sequential delivery of doxorubicin and tanespimycin.
Forced expression of heat-shock protein 70 increases the secretion of Hsp70 and provides protection against tumour growth.
Four new antitumor metabolites isolated from a mutant 3-f-31 strain derived from Penicillium purpurogenum G59.
FOXP2 promotes tumor proliferation and metastasis by targeting GRP78 in triple-negative breast cancer.
Fragment-based discovery of hydroxy-indazole-carboxamides as novel small molecule inhibitors of Hsp90.
Fragment-based drug discovery applied to Hsp90. Discovery of two lead series with high ligand efficiency.
From Bacteria to Cancer: A Benzothiazole-Based DNA Gyrase B Inhibitor Redesigned for Hsp90 C-Terminal Inhibition.
From protein-protein interaction to therapy response: molecular imaging of heat shock proteins.
FS-93, an Hsp90 inhibitor, induces G2/M arrest and apoptosis via the degradation of client proteins in oncogene addicted and derived resistant cancer cells.
Function of HSP90 and p23 in the telomerase complex of thyroid tumors.
Functional alterations in macrophages after hypoxia selection.
Functional analysis of Hsp70 inhibitors.
Functional and prognostic role of ZAP-70 in chronic lymphocytic leukaemia.
Functional characterization of heat shock protein 90 targeted compounds.
Functional chromatography reveals three natural products that target the same protein with distinct mechanisms of action.
Functional inactivation of endogenous MDM2 and CHIP by HSP90 causes aberrant stabilization of mutant p53 in human cancer cells.
Functional proteomic analysis reveals that fungal immunomodulatory protein reduced expressions of heat shock proteins correlates to apoptosis in lung cancer cells.
Functional proteomic screens reveal an essential extracellular role for hsp90 alpha in cancer cell invasiveness.
Functional role of Hsp60 as a positive regulator of human viral infection progression.
Functional significance of minor structural and expression changes in stress chaperone mortalin.
Functional Significance of Point Mutations in Stress Chaperone Mortalin and Their Relevance to Parkinson Disease.
Functional state of the Hsp27 chaperone as a molecular marker of an unfavorable course of larynx cancer.
Fungal mycotoxin penisuloxazin A, a novel C-terminal Hsp90 inhibitor and characteristics of its analogues on Hsp90 function related to binding sites.
Fused imidazoles as potential chemical scaffolds for inhibition of heat shock protein 70 and induction of apoptosis. Synthesis and biological evaluation of phenanthro[9,10-d]imidazoles and imidazo[4,5-f][1,10]phenanthrolines.
Fusion protein of ATPase domain of Hsc70 with TRP2 acting as a tumor vaccine against B16 melanoma.
GALNT6 Stabilizes GRP78 Protein by O-glycosylation and Enhances its Activity to Suppress Apoptosis Under Stress Condition.
Gambogic acid and gambogenic acid induce a thiol-dependent heat shock response and disrupt the interaction between HSP90 and HSF1 or HSF2.
Gambogic acid inhibits Hsp90 and deregulates TNF-?/NF-?B in HeLa cells.
Gamma delta T cell recognition of tumor Ig peptide.
gammadelta T cells lyse autologous and allogenic oesophageal tumours: involvement of heat-shock proteins in the tumour cell lysis.
Ganetespib and HSP90: Translating Preclinical Hypotheses into Clinical Promise.
Ganetespib blocks HIF-1 activity and inhibits tumor growth, vascularization, stem cell maintenance, invasion, and metastasis in orthotopic mouse models of triple-negative breast cancer.
Ganetespib for small cell lung cancer.
Ganetespib in Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitor-resistant Non-small Cell Lung Cancer.
Ganetespib induces G2/M cell cycle arrest and apoptosis in gastric cancer cells through targeting of receptor tyrosine kinase signaling.
Ganetespib targets multiple levels of the receptor tyrosine kinase signaling cascade and preferentially inhibits ErbB2-overexpressing breast cancer cells.
Ganetespib, a unique triazolone-containing Hsp90 inhibitor, exhibits potent antitumor activity and a superior safety profile for cancer therapy.
Ganetespib, an HSP90 inhibitor, kills Epstein-Barr virus (EBV)-infected B and T cells and reduces the percentage of EBV-infected cells in the blood.
Ganetespib: research and clinical development.
Gastroprotective effect of crocin in ethanol-induced gastric injury in rats.
Gedunin Inactivates the Co-chaperone p23 Protein Causing Cancer Cell Death by Apoptosis.
Gedunin isolated from the mangrove plant Xylocarpus granatum exerts its anti-proliferative activity in ovarian cancer cells through G2/M-phase arrest and oxidative stress-mediated intrinsic apoptosis.
Geldanamycin administration reduces the amount of primordial germ cells in the mouse embryo.
Geldanamycin Analog 17-DMAG Limits Apoptosis in Human Peripheral Blood Cells by Inhibition of p53 Activation and its Interaction with Heat-Shock Protein 90 kDa after Exposure to Ionizing Radiation.
Geldanamycin and 17-allylamino-17-demethoxygeldanamycin potentiate the in vitro and in vivo radiation response of cervical tumor cells via the heat shock protein 90-mediated intracellular signaling and cytotoxicity.
Geldanamycin and its anti-cancer activities.
Geldanamycin and its derivatives as Hsp90 inhibitors.
Geldanamycin anisimycins activate Rho and stimulate Rho- and ROCK-dependent actin stress fiber formation.
Geldanamycin as a potential anti-cancer agent: its molecular target and biochemical activity.
Geldanamycin induces cell cycle arrest in K562 erythroleukemic cells.
Geldanamycin promotes premature mitotic entry and micronucleation in irradiated p53/p21 deficient colon carcinoma cells.
Geldanamycin, an inhibitor of Hsp90, sensitizes human tumour cells to radiation.
Geldanamycin, radicicol, and chimeric inhibitors of the Hsp90 N-terminal ATP binding site.
Geldanamycin-induced osteosarcoma cell death is associated with hyperacetylation and loss of mitochondrial pool of heat shock protein 60 (hsp60).
Geldanamycin-Induced PCNA Degradation in Isolated Hsp90 Complex from Cancer Cells.
Geldanamycin-stimulated destabilization of mutated p53 is mediated by the proteasome in vivo.
Geldanamycins trigger a novel Ron degradative pathway, hampering oncogenic signaling.
Gene Copy Number and Post-Transductional Mechanisms Regulate TRAP1 Expression in Human Colorectal Carcinomas.
Gene expression of heat shock protein 70, interleukin-1? and tumor necrosis factor ? as tools to identify immunotoxic effects on Xenopus laevis: a dose-response study with benzo[a]pyrene and its degradation products.
Gene expression profiles of mitochondria-endoplasmic reticulum tethering in human gingival fibroblasts in response to periodontal pathogens.
Generation of anti-tumor immunity using mammalian heat shock protein 70 DNA vaccines for cancer immunotherapy.
Generation of cytotoxic T lymphocytes by MHC class I ligands fused to heat shock cognate protein 70.
Generation of multiple Peptide cocktail-pulsed dendritic cells as a cancer vaccine.
Genes and proteins governing the cellular sensitivity to HSP90 inhibitors: a mechanistic perspective.
Genetic association of promoter in GRP78 gene with nasopharyngeal carcinoma in a Chinese population.
Genetic polymorphisms and risk for acute renal failure in preterm neonates.
Genetic resistance to JAK2 enzymatic inhibitors is overcome by HSP90 inhibition.
Genetic susceptibility markers in Danish patients with type 1 (insulin-dependent) diabetes--evidence for polygenicity in man. Danish Study Group of Diabetes in Childhood.
Genetic susceptibility to carbamazepine-induced cutaneous adverse drug reactions.
Genetic variation in the tumor necrosis factor-alpha promoter region and in the stress protein hsp70-2: susceptibility and prognostic implications in breast carcinoma.
Genistein induces apoptosis in vitro and has antitumor activity against human leukemia HL-60 cancer cell xenograft growth in vivo.
Genome-wide analysis of differentially expressed genes during the early stages of tomato infection by a potyvirus.
Germ cell-specific heat shock protein 70-2 is expressed in cervical carcinoma and is involved in the growth, migration, and invasion of cervical cells.
Germacrone Inhibits Cell Proliferation and Induces Apoptosis in Human Esophageal Squamous Cell Carcinoma Cells.
Glioma: What is the role of c-Myc, hsp90 and telomerase?
Global targeting of subcellular heat shock protein-90 networks for therapy of glioblastoma.
Glu-108 in Saccharomyces cerevisiae Rad51 Is Critical for DNA Damage-Induced Nuclear Function.
Glucose oxidase-mediated tumor starvation therapy combined with photothermal therapy for colon cancer.
Glucose regulated protein 78 promotes cell invasion via regulation of uPA production and secretion in colon cancer cells.
Glucose regulated protein 78: A critical link between tumor microenvironment and cancer hallmarks.
Glucose regulated proteins in cancer progression, drug resistance and immunotherapy.
Glucose- regulated protein 78 (GRP78) in renal cell carcinoma: A novel biomarker for predicting tumor behavior.
Glucose-deprived HT-29 human colon carcinoma cells are sensitive to verrucosidin as a GRP78 down-regulator.
Glucose-regulated protein (GRP78) is an important cell surface receptor for viral invasion, cancers, and neurological disorders.
Glucose-regulated protein 78 (GRP78) as a potential novel biomarker and therapeutic target in multiple myeloma.
Glucose-regulated protein 78 (GRP78) regulates colon cancer metastasis through EMT biomarkers and the NRF-2/HO-1 pathway.
Glucose-Regulated Protein 78 (GRP78) Silencing Enhances Cell Migration but Does Not Influence Cell Proliferation in Hepatocellular Carcinoma.
Glucose-regulated protein 78 as a novel effector of BRCA1 for inhibiting stress-induced apoptosis.
Glucose-regulated protein 78 contributes to the proliferation and tumorigenesis of human colorectal carcinoma via AKT and ERK pathways.
Glucose-regulated protein 78 controls cross-talk between apoptosis and autophagy to determine antiestrogen responsiveness.
Glucose-regulated protein 78 expression in urothelial carcinoma of the upper urinary tract.
Glucose-Regulated Protein 78 Is a Novel Contributor to Acquisition of Resistance to Sorafenib in Hepatocellular Carcinoma.
Glucose-regulated protein 78 mediates the therapeutic efficacy of 17-DMAG in colon cancer cells.
Glucose-regulated protein 78 regulates multiple malignant phenotypes in head and neck cancer and may serve as a molecular target of therapeutic intervention.
Glucose-regulated protein 78 silencing down-regulates vascular endothelial growth factor/vascular endothelial growth factor receptor 2 pathway to suppress human colon cancer tumor growth.
Glucose-regulated protein GRP78 is up-regulated in prostate cancer and correlates with recurrence and survival.
Glucose-related protein (GRP78) and its relationship to the drug-resistance proteins P170, GST-pi, LRP56 and angiogenesis in non-small cell lung carcinomas.
Glucose-Related Protein 78 Expression and Its Effects on Cisplatin-Resistance in Cervical Cancer.
Glutamine attenuates tumor necrosis factor-alpha release and enhances heat shock protein 72 in human peripheral blood mononuclear cells.
Glutamine Synthetase, Heat shock Protein-70, and Glypican-3 in Intrahepatic Cholangiocarcinoma and Tumors Metastatic to Liver.
Gold nanoparticles loaded with cullin-5 DNA increase sensitivity to 17-AAG in cullin-5 deficient breast cancer cells.
Goniothalamin enhances the ATPase activity of the molecular chaperone Hsp90 but inhibits its chaperone activity.
Gp96 Peptide Antagonist gp96-II Confers Therapeutic Effects in Murine Intestinal Inflammation.
Gr(i)p the ER to Stress Out Melanoma.
Granulin-epithelin precursor interacts with 78-kDa glucose-regulated protein in hepatocellular carcinoma.
Granulocyte-macrophage colony-stimulating factor gene-transduced tumor cells combined with tumor-derived gp96 inhibit tumor growth in mice.
Granzyme B Functionalized Nanoparticles Targeting Membrane Hsp70-Positive Tumors for Multimodal Cancer Theranostics.
Green synthesis of ultra-small VOx nanodots for acidic-activated HSP60 inhibition and therapeutic enhancement.
Green tea epigallocatechin gallate enhances therapeutic efficacy of temozolomide in orthotopic mouse glioblastoma models.
Growth inhibition of re-challenge B16 melanoma transplant by conjugates of melanogenesis substrate and magnetite nanoparticles as the basis for developing melanoma-targeted chemo-thermo-immunotherapy.
GRP-78 secreted by tumor cells blocks the anti-angiogenic activity of bortezomib.
GRP78 / BiP / HSPA5 / Dna K is a universal therapeutic target for human disease.
GRP78 and next generation cancer hallmarks: An underexplored molecular target in cancer chemoprevention research.
GRP78 as a Novel Predictor of Responsiveness to Chemotherapy in Breast Cancer.
GRP78 as a regulator of liver steatosis and cancer progression mediated by loss of the tumor suppressor PTEN.
Grp78 as a therapeutic target for refractory head-neck cancer with CD24(-)CD44(+) stemness phenotype.
GRP78 as potential predictor for breast cancer response to adjuvant taxane therapy.
GRP78 at the Centre of the Stage in Cancer and Neuroprotection.
GRP78 enabled micelle-based glioma targeted drug delivery.
GRP78 enhances the glutamine metabolism to support cell survival from glucose deficiency by modulating the ?-catenin signaling.
GRP78 expression correlates with histologic differentiation and favorable prognosis in neuroblastic tumors.
GRP78 expression in tumor and perinephric adipose tissue is not an optimal risk stratification marker for clear cell renal cell carcinoma.
GRP78 haploinsufficiency suppresses acinar-to-ductal metaplasia, signaling, and mutant Kras-driven pancreatic tumorigenesis in mice.
GRP78 in lung cancer.
GRP78 induction in cancer: therapeutic and prognostic implications.
GRP78 Influences Chemoresistance and Prognosis in Cancer.
GRP78 inhibition enhances ATF4-induced cell death by the deubiquitination and stabilization of CHOP in human osteosarcoma.
GRP78 Is a Targetable Receptor on Cancer and Stromal Cells.
GRP78 is implicated in the modulation of tumor aerobic glycolysis by promoting autophagic degradation of IKK?.
GRP78 is overexpressed in glioblastomas and regulates glioma cell growth and apoptosis.
GRP78 Mediates Cell Growth and Invasiveness in Endometrial Cancer.
GRP78 mediates radiation resistance of a stem cell-like subpopulation within the MCF-7 breast cancer cell line.
GRP78 mediates the therapeutic efficacy of curcumin on colon cancer.
GRP78 modulates cell adhesion markers in prostate Cancer and multiple myeloma cell lines.
GRP78 plays an integral role in tumor cell inflammation-related migration induced by M2 macrophages.
GRP78 positively regulates estrogen?stimulated cell growth mediated by ER??36 in gastric cancer cells.
GRP78 promoter polymorphism rs391957 as potential predictor for clinical outcome in gastric and colorectal cancer patients.
GRP78 Promotes Hepatocellular Carcinoma proliferation by increasing FAT10 expression through the NF-?B pathway.
Grp78 promotes the invasion of hepatocellular carcinoma.
GRP78 promotes the invasion of pancreatic cancer cells by FAK and JNK.
GRP78 regulates CD44v membrane homeostasis and cell spreading in tamoxifen-resistant breast cancer.
GRP78 secreted by colon cancer cells facilitates cell proliferation via PI3K/Akt signaling.
GRP78 secreted by tumor cells stimulates differentiation of bone marrow mesenchymal stem cells to cancer-associated fibroblasts.
GRP78 signaling hub a receptor for targeted tumor therapy.
GRP78 targeting: Hitting two birds with a stone.
GRP78 up-regulation is associated with androgen receptor status, Hsp70-Hsp90 client proteins and castrate-resistant prostate cancer.
GRP78-targeted in-silico virtual screening of novel anticancer agents.
GRP78-targeted nanotherapy against castrate-resistant prostate cancer cells expressing membrane GRP78.
GRP78-targeting subtilase cytotoxin sensitizes cancer cells to photodynamic therapy.
GRP78/BiP inhibits endoplasmic reticulum BIK and protects human breast cancer cells against estrogen starvation-induced apoptosis.
GRP78/Dna K Is a Target for Nexavar/Stivarga/Votrient in the Treatment of Human Malignancies, Viral Infections and Bacterial Diseases.
GRP78: A cell's response to stress.
Grp94 in complexes with IgG is a soluble diagnostic marker of gastrointestinal tumors and displays immune-stimulating activity on peripheral blood immune cells.
GRP94/gp96 elicits ERK activation in murine macrophages. A role for endotoxin contamination in NF-kappa B activation and nitric oxide production.
Guardian of the furnace: mitochondria, TRAP1, ROS and stem cell maintenance.
Guizhi-Shaoyao-Zhimu decoction attenuates rheumatoid arthritis partially by reversing inflammation-immune system imbalance.
Haematoporphyrin based photodynamic therapy combined with hyperthermia provided effective therapeutic vaccine effect against colon cancer growth in mice.
Hansenula polymorpha expressed heat shock protein gp96 exerts potent T cell activation activity as an adjuvant.
HBP21, a chaperone of heat shock protein 70, functions as a tumor suppressor in hepatocellular carcinoma.
HDAC6 deacetylates p53 at lysines 381/382 and differentially coordinates p53-induced apoptosis.
HDN-1 induces cell differentiation toward apoptosis in promyelocytic leukemia cells depending on its selective effect on client proteins of Hsp90.
Heat induced release of Hsp70 from prostate carcinoma cells involves both active secretion and passive release from necrotic cells.
Heat shock and 5-azacytidine inhibit nitric oxide synthesis and tumor necrosis factor-alpha secretion in activated macrophages.
Heat shock cognate 70 mutations in sporadic breast carcinoma.
Heat shock cognate 70 protein secretion as a new growth arrest signal for cancer cells.
Heat shock cognate protein 70 encodes antigenic epitopes recognised by HLA-B4601-restricted cytotoxic T lymphocytes from cancer patients.
Heat Shock Cognate Protein 70 Enhanced Integrin ?1 Mediated Invasion in Cancer Cells.
Heat shock factor 1 confers resistance to Hsp90 inhibitors through p62/SQSTM1 expression and promotion of autophagic flux.
Heat shock factor 1 confers resistance to lapatinib in ERBB2-positive breast cancer cells.
Heat shock fusion protein induces both specific and nonspecific anti-tumor immunity.
Heat shock protein (HSP)27: a further refinement in the diagnosis of suspicious fine needle aspirates of breast.
Heat shock protein (HSP70) expression in septic patients.
Heat shock protein 10 (Hsp10) in immune-related diseases: one coin, two sides.
Heat shock protein 10 inhibits lipopolysaccharide-induced inflammatory mediator production.
Heat shock protein 105 is overexpressed in a variety of human tumors.
Heat shock protein 105 is overexpressed in squamous cell carcinoma and extramammary Paget disease but not in basal cell carcinoma.
Heat shock protein 105 peptide vaccine could induce antitumor immune reactions in a phase I clinical trial.
Heat shock protein 22 overexpression is associated with the progression and prognosis in gastric cancer.
Heat Shock protein 27 (HSP27, HSPB1) is synthetic lethal to cells with oncogenic activation of MET, EGFR and BRAF.
Heat shock protein 27 and p16 immunohistochemistry in cervical intraepithelial neoplasia and squamous cell carcinoma.
Heat Shock Protein 27 as a New Therapeutic Target for Radiation Sensitization of Head and Neck Squamous Cell Carcinoma.
Heat shock protein 27 as a prognostic and predictive biomarker in pancreatic ductal adenocarcinoma.
Heat shock protein 27 association with the I kappa B kinase complex regulates tumor necrosis factor alpha-induced NF-kappa B activation.
Heat Shock Protein 27 Expression is Inversely Correlated with Atrophic Gastritis and Intraepithelial Neoplasia.
Heat shock protein 27 is a potential indicator for response to YangZheng XiaoJi and chemotherapy agents in cancer cells.
Heat shock protein 27 is associated with irinotecan resistance in human colorectal cancer cells.
Heat shock protein 27 is expressed in normal and malignant human melanocytes in vivo.
Heat shock protein 27 is over-expressed in tumor tissues and increased in sera of patients with gastric adenocarcinoma.
Heat Shock Protein 27 Phosphorylation Regulates Tumor Cell Migration under Shear Stress.
Heat shock protein 27 phosphorylation state is associated with cancer progression.
Heat shock protein 27 phosphorylation: kinases, phosphatases, functions and pathology.
Heat shock protein 27 protects L929 cells from cisplatin-induced apoptosis by enhancing Akt activation and abating suppression of thioredoxin reductase activity.
Heat shock protein 27 was up-regulated in cisplatin resistant human ovarian tumor cell line and associated with the cisplatin resistance.
Heat Shock Protein 27-Targeted Heptapeptide of the PKC? Catalytic V5 Region Sensitizes Tumors with Radio- and Chemoresistance.
Heat shock protein 47 expression in oral squamous cell carcinomas and upregulated by arecoline in human oral epithelial cells.
Heat Shock Protein 47 Maintains Cancer Cell Growth by Inhibiting the Unfolded Protein Response Transducer IRE1?.
Heat shock protein 47 promotes tumor survival and therapy resistance by modulating AKT signaling via PHLPP1 in colorectal cancer.
Heat shock protein 47 regulated by miR-29a to enhance glioma tumor growth and invasion.
Heat Shock Protein 60 as a Mediator of Adipose Tissue Inflammation and Insulin Resistance.
Heat shock protein 60 causes osteoclastic bone resorption via toll-like receptor-2 in estrogen deficiency.
Heat Shock Protein 60 in Hepatocellular Carcinoma: Insights and Perspectives.
Heat shock protein 60 levels in tissue and circulating exosomes in human large bowel cancer before and after ablative surgery.
Heat shock protein 60 overexpression is associated with the progression and prognosis in gastric cancer.
Heat Shock Protein 60 Regulation of the Mitochondrial Permeability Transition Pore in Tumor Cells.
Heat shock protein 70 (Hsp70) membrane expression on head-and-neck cancer biopsy-a target for natural killer (NK) cells.
Heat Shock Protein 70 (Hsp70) Peptide Activated Natural Killer (NK) Cells for the Treatment of Patients with Non-Small Cell Lung Cancer (NSCLC) after Radiochemotherapy (RCTx) - From Preclinical Studies to a Clinical Phase II Trial.
Heat shock protein 70 / MAGE-1 tumor vaccine can enhance the potency of MAGE-1-specific cellular immune responses in vivo.
Heat shock protein 70 and glycoprotein 96 are differentially expressed on the surface of malignant and nonmalignant breast cells.
Heat shock protein 70 and HLA-DR molecules tissue expression. Prognostic implications in colorectal cancer.
Heat shock protein 70 and nitric oxide concentrations in non-tumorous and neoplastic canine mammary tissues: preliminary results - Short communication.
Heat shock protein 70 and tumor necrosis factor alpha in Taiwanese patients with dementia.
Heat shock protein 70 and tumor-infiltrating NK cells as prognostic indicators for patients with squamous cell carcinoma of the head and neck after radiochemotherapy: A multicentre retrospective study of the German Cancer Consortium Radiation Oncology Group (DKTK-ROG).
Heat shock protein 70 antisense oligonucleotide inhibits cell growth and induces apoptosis in human gastric cancer cell line SGC-7901.
Heat shock protein 70 downregulation inhibits proliferation, migration and tumorigenicity in hepatocellular carcinoma cells.
Heat shock protein 70 expression and effect of combined transcatheter arterial embolization and radiofrequency ablation in the rabbit VX2 liver tumour model.
Heat shock protein 70 gene polymorphisms and cancer risk: a meta-analysis.
Heat shock protein 70 genotypes HSPA1B and HSPA1L influence cytokine concentrations and interfere with outcome after major injury.
Heat shock protein 70 induced during tumor cell killing induces Th1 cytokines and targets immature dendritic cell precursors to enhance antigen uptake.
Heat shock protein 70 inhibitors. 1. 2,5'-thiodipyrimidine and 5-(phenylthio)pyrimidine acrylamides as irreversible binders to an allosteric site on heat shock protein 70.
Heat shock protein 70 inhibitors. 2. 2,5'-thiodipyrimidines, 5-(phenylthio)pyrimidines, 2-(pyridin-3-ylthio)pyrimidines, and 3-(phenylthio)pyridines as reversible binders to an allosteric site on heat shock protein 70.
Heat shock protein 70 inhibits apoptosis in cancer cells through simultaneous and independent mechanisms.
Heat shock protein 70 is able to prevent heat shock-induced resistance of target cells to CTL.
Heat shock protein 70 is acute phase reactant: response elicited by tumor treatment with photodynamic therapy.
Heat shock protein 70 is induced in mouse human colon tumor xenografts after sublethal radiofrequency ablation.
Heat shock protein 70 is required for the survival of cancer cells.
Heat shock protein 70 is secreted from tumor cells by a nonclassical pathway involving lysosomal endosomes.
Heat shock protein 70 membrane expression and melanoma-associated marker phenotype in primary and metastatic melanoma.
Heat shock protein 70 neutralization exerts potent antitumor effects in animal models of colon cancer and melanoma.
Heat shock protein 70 promotes cancer cell viability by safeguarding lysosomal integrity.
Heat shock protein 70 promotes cell survival by inhibiting lysosomal membrane permeabilization.
Heat shock protein 70 silencing enhances apoptosis inducing factor-mediated cell death in hepatocellular carcinoma HepG(2) cells.
Heat shock protein 70 surface-positive tumor exosomes stimulate migratory and cytolytic activity of natural killer cells.
Heat shock protein 70 upregulation by geldanamycin reduces brain injury in a mouse model of intracerebral hemorrhage.
Heat shock protein 70, erythropoietin, and cancer.
Heat shock protein 70, released from heat-stressed tumor cells, initiates antitumor immunity by inducing tumor cell chemokine production and activating dendritic cells via TLR4 pathway.
Heat shock protein 70-2 (HSP70-2) a novel cancer testis antigen that promotes growth of ovarian cancer.
Heat shock protein 70-2 (HSP70-2) is a novel therapeutic target for colorectal cancer and is associated with tumor growth.
Heat shock protein 70-2 (HSP70-2) overexpression in breast cancer.
Heat shock protein 70-2 and tumor necrosis factor-? gene polymorphisms in Chinese children with Henoch-Schönlein purpura.
Heat shock protein 70-associated peptides elicit specific cancer immunity.
Heat shock protein 72 expression in osteosarcomas correlates with good response to neoadjuvant chemotherapy.
Heat shock protein 72 on tumor cells: a recognition structure for natural killer cells.
Heat Shock Protein 90 (HSP90) and Her2 in Adenocarcinomas of the Esophagus.
Heat shock protein 90 (hsp90) expression and breast cancer.
Heat Shock Protein 90 (Hsp90) inhibitor occupancy is a direct determinant of client protein degradation and tumor growth arrest in vivo.
Heat Shock Protein 90 (Hsp90)-Inhibitor-Luminespib-Loaded-Protein-Based Nanoformulation for Cancer Therapy.
Heat Shock Protein 90 Alpha, Lass B Member 1: a Key Regulative Gene of Monitoring Duodenal Tumor for Obesity Induced by High-Fat Diet.
Heat shock protein 90 and role of its chemical inhibitors in treatment of hematologic malignancies.
Heat shock protein 90 as a molecular target for cancer therapeutics.
Heat Shock Protein 90 as a Prognostic Marker and Therapeutic Target for Adrenocortical Carcinoma.
Heat Shock Protein 90 Family Isoforms as Prognostic Biomarkers and Their Correlations with Immune Infiltration in Breast Cancer.
Heat shock protein 90 in neurodegenerative diseases.
Heat shock protein 90 in plants: molecular mechanisms and roles in stress responses.
Heat shock protein 90 inhibition abrogates hepatocellular cancer growth through cdc2-mediated G(2)/M cell cycle arrest and apoptosis.
Heat shock protein 90 inhibition by 17-Dimethylaminoethylamino-17-demethoxygeldanamycin protects blood-brain barrier integrity in cerebral ischemic stroke.
Heat Shock Protein 90 Inhibition Depletes LATS1 and LATS2, Two Regulators of the Mammalian Hippo Tumor Suppressor Pathway.
Heat Shock Protein 90 Inhibition in Cancer Drug Discovery: From Chemistry to Futural Clinical Applications.
Heat shock protein 90 inhibition in imatinib-resistant gastrointestinal stromal tumor.
Heat shock protein 90 inhibition in the inflamed lungs.
Heat shock protein 90 inhibition is cytotoxic to primary AML cells expressing mutant FLT3 and results in altered downstream signalling.
Heat shock protein 90 inhibition results in altered downstream signaling of mutant KIT and exerts synergistic effects on Kasumi-1 cells when combining with histone deacetylase inhibitor.
Heat shock protein 90 inhibition: A potential double- or triple-edged sword in the treatment of mucous membrane pemphigoid.
Heat shock protein 90 inhibition: rationale and clinical potential.
Heat shock protein 90 inhibitor 17-allylamino-17-demethoxygeldanamycin potentiates the radiation response of tumor cells grown as monolayer cultures and spheroids by inducing apoptosis.
Heat shock protein 90 inhibitor 17-dimethylaminoethylamino-17-demethoxygeldanamycin enhances EphA2+ tumor cell recognition by specific CD8+ T cells.
Heat shock protein 90 inhibitor BIIB021 (CNF2024) depletes NF-kappaB and sensitizes Hodgkin's lymphoma cells for natural killer cell-mediated cytotoxicity.
Heat Shock Protein 90 Inhibitor Effects on Pancreatic Cancer Cell Cultures.
Heat shock protein 90 inhibitor is synergistic with JAK2 inhibitor and overcomes resistance to JAK2-TKI in human myeloproliferative neoplasm cells.
Heat shock protein 90 inhibitor mycoepoxydiene modulates kinase signaling in cervical cancer cells and inhibits in-vivo tumor growth.
Heat shock protein 90 inhibitor regulates necroptotic cell death via down-regulation of receptor interacting proteins.
Heat Shock Protein 90 Inhibitors as Therapeutic Agents.
Heat Shock Protein 90 Inhibitors AUY922, BIIB021 and SNX5422 Induce Bim-mediated Death of Thyroid Carcinoma Cells.
Heat shock protein 90 inhibitors block the antinociceptive effects of opioids in mouse chemotherapy-induced neuropathy and cancer bone pain models.
Heat shock protein 90 inhibitors in non-small-cell lung cancer.
Heat shock protein 90 inhibitors in the treatment of cancer: current status and future directions.
Heat shock protein 90 inhibitors induce functional inhibition of human natural killer cells in a dose-dependent manner.
Heat shock protein 90 inhibitors repress latent membrane protein 1 (LMP1) expression and proliferation of Epstein-Barr virus-positive natural killer cell lymphoma.
Heat shock protein 90 inhibitors suppress aryl hydrocarbon receptor-mediated activation of CYP1A1 and CYP1B1 transcription and DNA adduct formation.
Heat Shock Protein 90 Inhibitors: An Update on Achievements, Challenges, and Future Directions.
Heat Shock Protein 90 Inhibitors: New Mode of Therapy to Overcome Endocrine Resistance.
Heat Shock Protein 90 Is a Potential Therapeutic Target in Cholangiocarcinoma.
Heat shock protein 90 is a promising target for effective growth inhibition of gastrointestinal neuroendocrine tumors.
Heat shock protein 90 is a putative therapeutic target in patients with recurrent advanced-stage ovarian carcinoma with serous effusions.
Heat shock protein 90 is a rational molecular target in breast cancer.
Heat Shock Protein 90 is Associated with Hyperplasia and Neoplastic Transformation of Canine Prostatic Epithelial Cells.
Heat shock protein 90 is critical for regulation of phenotype and functional activity of human T lymphocytes and NK cells.
Heat shock protein 90 is involved in the regulation of HMGA2-driven growth and epithelial-to-mesenchymal transition of colorectal cancer cells.
Heat shock protein 90 mediates the apoptosis and autophage in nicotinic-mycoepoxydiene-treated HeLa cells.
Heat shock protein 90 overexpression independently predicts inferior disease-free survival with differential expression of the alpha and beta isoforms in gastrointestinal stromal tumors.
Heat shock protein 90 promotes RNA helicase DDX5 accumulation and exacerbates hepatocellular carcinoma by inhibiting autophagy.
Heat shock protein 90 regulates phosphatidylinositol 3-kinase-related protein kinase family proteins together with the RUVBL1/2 and Tel2-containing co-factor complex.
Heat Shock Protein 90 Regulates Subcellular Localization of Smads in Mv1Lu Cells.
Heat shock protein 90 regulates the metaphase-anaphase transition in a polo-like kinase-dependent manner.
Heat shock protein 90 suppresses tumor necrosis factor alpha induced apoptosis by preventing the cleavage of Bid in NIH3T3 fibroblasts.
Heat shock protein 90 targets a chaperoned peptide to the static early endosome for efficient cross-presentation by human dendritic cells.
Heat Shock Protein 90 Triggers Multi-Drug Resistance of Ovarian Cancer via AKT/GSK3?/?-Catenin Signaling.
Heat shock protein 90-? over-expression is associated with poor survival in stage I lung adenocarcinoma patients.
Heat shock protein 90-mediated peptide-selective presentation of cytosolic tumor antigen for direct recognition of tumors by CD4(+) T cells.
Heat shock protein 90-sheltered overexpression of insulin-like growth factor 1 receptor contributes to malignancy of thymic epithelial tumors.
Heat shock protein 90-targeted photodynamic therapy enables treatment of subcutaneous and visceral tumors.
Heat shock protein 90.
Heat shock protein 90: a pathophysiological factor and novel treatment target in autoimmune bullous skin diseases.
Heat shock protein 90: a unique chemotherapeutic target.
Heat shock protein 90: its inhibition and function.
Heat shock protein 90: the cancer chaperone.
Heat shock protein 90: translation from cancer to Alzheimer's disease treatment?
Heat shock protein 90? in thymic epithelial tumors and non-thymomatous myasthenia gravis.
Heat Shock Protein 90? Provides an Effective and Novel Diagnosis Strategy for Nasopharyngeal Carcinoma.
Heat shock protein 90alpha recruits FLIPS to the death-inducing signaling complex and contributes to TRAIL resistance in human glioma.
Heat shock protein 90B1 plays an oncogenic role and is a target of microRNA-223 in human osteosarcoma.
Heat shock protein and p53 expression in head and neck squamous cell carcinoma.
Heat shock protein as molecular targets for breast cancer therapeutics.
Heat Shock Protein Association with Clinico-Pathological Characteristics of Gastric Cancer in Jordan : HSP70 is Predictive of Poor Prognosis.
Heat shock protein B6 potently increases non-small cell lung cancer growth.
Heat shock protein B8 promotes proliferation and migration in lung adenocarcinoma A549 cells by maintaining mitochondrial function.
Heat shock protein B8, a cyclin-dependent kinase-independent cyclin D1 target gene, contributes to its effects on radiation sensitivity.
Heat shock protein derived from a non-autologous tumour can be used as an anti-tumour vaccine.
Heat shock protein expression analysis in canine osteosarcoma reveals HSP60 as a potentially relevant therapeutic target.
Heat shock protein expression and drug resistance in breast cancer patients treated with induction chemotherapy.
Heat shock protein expression and injury optimization for laser therapy design.
Heat shock protein expression and temperature distribution in prostate tumours treated with laser irradiation and nanoshells.
Heat shock protein expression in canine malignant mammary tumours.
Heat shock protein expression in canine osteosarcoma.
Heat shock protein expression in human gliomas.
Heat shock protein expression in human tumours grown in severe combined immunodeficient mice.
Heat shock protein expression in oral epithelial dysplasia and squamous cell carcinoma.
Heat shock protein expression in the eye and in uveal melanoma.
Heat shock protein expression independently predicts clinical outcome in prostate cancer.
Heat shock protein gp96 and cancer immunotherapy.
Heat shock protein gp96 decreases p53 stability by regulating Mdm2 E3 ligase activity in liver cancer.
Heat shock protein hsp70 in patients with axillary lymph node-negative breast cancer: prognostic implications.
Heat shock protein Hsp72 controls oncogene-induced senescence pathways in cancer cells.
Heat shock protein Hsp72 plays an essential role in Her2-induced mammary tumorigenesis.
Heat Shock Protein Inhibitor 17-Allyamino-17-Demethoxygeldanamycin, a Potent Inductor of Apoptosis in Human Glioma Tumor Cell Lines, Is a Weak Substrate for ABCB1 and ABCG2 Transporters.
Heat shock protein inhibitor, quercetin, as a novel adjuvant agent to improve radiofrequency ablation-induced tumor destruction and its molecular mechanism.
Heat shock protein inhibitors and vaccines as new agents in cancer treatment.
Heat shock protein inhibitors increase the efficacy of measles virotherapy.
Heat shock protein reactivity of lymphocytes isolated from heterotopic rat cardiac allografts.
Heat shock protein response in a prostate tumor model to interstitial thermotherapy: implications for clinical treatment.
Heat shock protein vaccination and directed IL-2 therapy amplify tumor immunity rapidly following bone marrow transplantation in mice.
Heat shock protein vaccines against cancer.
Heat shock protein-60 expression was significantly correlated with the prognosis of lung adenocarcinoma.
Heat shock protein-70 expressed on the surface of cancer cells binds parathyroid hormone-related protein in vitro.
Heat Shock Protein-90 Inhibition Alters Activation of Pancreatic Stellate Cells and Enhances the Efficacy of PD-1 Blockade in Pancreatic Cancer.
Heat shock protein-90 inhibitors enhance antigen expression on melanomas and increase T cell recognition of tumor cells.
Heat shock protein-90 inhibitors: a chronicle from geldanamycin to today's agents.
Heat shock protein-90-alpha, a prolactin-STAT5 target gene identified in breast cancer cells, is involved in apoptosis regulation.
Heat shock protein-guided dual-mode CT/MR imaging of orthotopic hepatocellular carcinoma tumor.
Heat Shock Protein-Peptide and HSP-Based Immunotherapies for the Treatment of Cancer.
Heat shock protein-peptide complexes, reconstituted in vitro, elicit peptide-specific cytotoxic T lymphocyte response and tumor immunity.
Heat shock protein90 in lobular neoplasia of the breast.
Heat Shock Proteins (HSPs) based anti-cancer vaccines.
Heat shock proteins and cancer: How can nanomedicine be harnessed?
Heat shock proteins and cancer: intracellular chaperones or extracellular signalling ligands?
Heat shock proteins and cell proliferation in human breast cancer biopsy samples.
Heat Shock Proteins Are Essential Components in Transformation and Tumor Progression: Cancer Cell Intrinsic Pathways and Beyond.
Heat shock proteins as emerging therapeutic targets.
Heat shock proteins as novel therapeutic targets in cancer.
Heat shock proteins as prognostic markers of cancer.
Heat shock proteins as regulators of the immune response.
Heat shock proteins as targets in oncology.
Heat shock proteins HSP27, HSP60, HSP70, and HSP90: expression in bladder carcinoma.
Heat shock proteins in breast cancer progression--a suitable case for treatment?
Heat shock proteins in cancer: chaperones of tumorigenesis.
Heat shock proteins in cancer: diagnostic, prognostic, predictive, and treatment implications.
Heat shock proteins in cancer: targeting the 'chaperones'.
Heat shock proteins in glioblastomas.
Heat shock proteins in multiple myeloma.
Heat shock proteins with an emphasis on HSP 60.
Heat shock proteins, autoimmunity, and cancer treatment.
Heat Shock Proteins: A Potential Anticancer Target.
Heat shock proteins: a therapeutic target worth to consider.
Heat shock proteins: their role in urological tumors.
Heat Stress and Feed Restriction Distinctly Affect Performance, Carcass and Meat Yield, Intestinal Integrity, and Inflammatory (Chemo)Cytokines in Broiler Chickens.
Heat-activated nanomedicine formulation improves the anticancer potential of the HSP90 inhibitor luminespib in vitro.
Heat-shock protein 70 as a tumor antigen for in vitro dendritic cell pulsing in renal cell carcinoma cases.
Heat-shock protein 70 binds to a novel sequence in 5' UTR of tumor suppressor SMAR1 and regulates its mRNA stability upon Prostaglandin A2 treatment.
Heat-shock protein 70-2 (HSP70-2) expression in bladder urothelial carcinoma is associated with tumour progression and promotes migration and invasion.
Heat-shock protein 70: expression in monocytes of patients with sleep apnoea and association with oxidative stress and tumour necrosis factor-alpha.
Heat-shock protein 90 (Hsp90) as a molecular target for therapy of gastrointestinal cancer.
Heat-shock protein 90 (Hsp90) as anticancer target for drug discovery: an ample computational perspective.
Heat-shock protein 90 inhibitors as antitumor agents: a survey of the literature from 2005 to 2010.
Heat-shock protein 90 inhibitors as novel cancer chemotherapeutic agents.
Heat-shock protein 90 inhibitors as novel cancer chemotherapeutics - an update.
Heat-shock protein 90 inhibitors in antineoplastic therapy: is it all wrapped up?
Heat-shock protein 90 inhibitors in cancer therapy: 17AAG and beyond.
Heat-shock protein 90: potential involvement in the pathogenesis of malignancy and pharmacological intervention.
HECTD3 Mediates an HSP90-Dependent Degradation Pathway for Protein Kinase Clients.
Helicobacter pylori heat shock protein 60 antibodies are associated with gastric cancer.
Helicobacter pylori-downregulated tumor necrosis factor receptor-associated protein 1 mediates apoptosis of human gastric epithelial cells.
Hepatic Microwave Ablation-Induced Tumor Destruction and Animal End Point Survival Can Be Improved by Suppression of Heat Shock Protein 90.
Hepatic Thermal Ablation: Effect of Device and Heating Parameters on Local Tissue Reactions and Distant Tumor Growth.
Hepatitis B virus protein up-regulated HLJ1 expression via the transcription factor YY1 in human hepatocarcinoma cells.
Hepatitis B virus X protein upregulates HSP90alpha expression via activation of c-Myc in human hepatocarcinoma cell line, HepG2.
Hepatocellular tumors: immunohistochemical analyses for classification and prognostication.
HER2-positive advanced breast cancer: optimizing patient outcomes and opportunities for drug development.
HER2/ErbB2 activates HSF1 and thereby controls HSP90 clients including MIF in HER2-overexpressing breast cancer.
Herbimycins D-F, Ansamycin Analogues from Streptomyces sp. RM-7-15.
Heterocyclic drug-polymer conjugates for cancer targeted drug delivery.
HIF-1alpha and STAT3 client proteins interacting with the cancer chaperone Hsp90: Therapeutic Considerations.
HIF1?-dependent induction of the mitochondrial chaperone TRAP1 regulates bioenergetic adaptations to hypoxia.
High anti tumor activity against rhabdomyosarcoma cells and low normal cells cytotoxicity of heat shock protein 90 inhibitors, with special emphasis on 17-[2-(pyrrolidin-1-yl)ethyl]-aminno-17-demethoxygeldanamycin.
High concentrations of environmental ammonia induced changes in large-scale loach (Paramisgurnus dabryanus) immunity.
High expression of glucose-regulated protein 78 (GRP78) is associated with metastasis and poor prognosis in patients with esophageal squamous cell carcinoma.
High expression of GRP78/BiP as a novel predictor of favorable outcomes in patients with advanced thymic carcinoma.
High expression of heat shock protein 105 predicts a favorable prognosis for patients with urinary bladder cancer treated with radical cystectomy.
High expression of heat shock protein 90 is associated with tumor aggressiveness and poor prognosis in patients with advanced gastric cancer.
High expression of heat shock proteins and heat shock factor-1 distinguishes an aggressive subset of clear cell renal cell carcinoma.
High expression of HSP90 is associated with poor prognosis in patients with colorectal cancer.
High glucose uptake unexpectedly is accompanied by high levels of the mitochondrial ß-F1-ATPase subunit in head and neck squamous cell carcinoma.
High HSP90 expression is associated with decreased survival in breast cancer.
High HSPA8 expression predicts adverse outcomes of acute myeloid leukemia.
High Ki67, Bax, and thymidylate synthase expression well correlates with response to chemoradiation therapy in locally advanced rectal cancers: proposal of a logistic model for prediction.
High Level Soluble Expression and ATPase Characterization of Human Heat Shock Protein GRP78.
High levels of heat shock protein 70 are associated with pro-inflammatory cytokines and may differentiate early- from late-onset preeclampsia.
High levels of heat shock protein Hsp72 in cancer cells suppress default senescence pathways.
High Levels of Hsp90 Cochaperone p23 Promote Tumor Progression and Poor Prognosis in Breast Cancer by Increasing Lymph Node Metastases and Drug Resistance.
High-Content, High-Throughput Analysis of Cell Cycle Perturbations Induced by the HSP90 Inhibitor XL888.
High-throughput screen of natural product libraries for hsp90 inhibitors.
High-throughput screening assay for inhibitors of heat-shock protein 90 ATPase activity.
High-throughput screening fluorescence polarization assay for tumor-specific hsp90.
High-throughput screening identifies small molecule inhibitors of molecular chaperones.
High-yield expression and purification of the Hsp90-associated p23, FKBP52, HOP and SGT? proteins.
Higher induction of heat shock protein 72 by heat stress in cisplatin-resistant than in cisplatin-sensitive cancer cells.
Highlights in experimental therapeutics.
Hippocampal and Cerebellar Changes in Acute Restraint Stress and the Impact of Pretreatment with Ceftriaxone.
Histocompatibility leucocyte antigens and closely linked immunomodulatory genes in autoimmune thyroid disease.
Histologic grade and CD44 are independent predictors of axillary lymph node invasion in early (T1) breast cancer.
Histological and immunohistochemical effects of L-arginine and silymarin on TNBS-induced inflammatory bowel disease in rats.
Histological effect and protein expression in subthreshold transpupillary thermotherapy in rabbit eyes.
Histone deacetylase 6 in cancer.
Histone deacetylase activity mediates acquired resistance towards structurally diverse HSP90 inhibitors.
Histone deacetylase inhibitor valproic acid inhibits cancer cell proliferation via down-regulation of the alzheimer amyloid precursor protein.
Histone deacetylase inhibitors modulating non-epigenetic players: The novel molecular targets for therapeutic intervention.
Histone deacetylation : an attractive target for cancer therapy?
HLA class I binding of synthetic nonamer peptides carrying major anchor residue motifs of HLA-B27 (B*2705)-binding peptides.
HLJ1 is a novel caspase-3 substrate and its expression enhances UV-induced apoptosis in non-small cell lung carcinoma.
Honokiol Bis-Dichloroacetate Is a Selective Allosteric Inhibitor of the Mitochondrial Chaperone TRAP1.
Hormone-refractory breast cancer remains sensitive to the antitumor activity of heat shock protein 90 inhibitors.
How autophagy controls the intestinal epithelial barrier.
How Selective are Hsp90 Inhibitors for Cancer Cells over Normal Cells?
HPMA Copolymer-Aminohexylgeldanamycin Conjugates Targeting Cell Surface Expressed GRP78 in Prostate Cancer.
Hsc70 contributes to cancer cell survival by preventing Rab1A degradation under stress conditions.
HSF1: Primary Factor in Molecular Chaperone Expression and a Major Contributor to Cancer Morbidity.
HSP 70 synthesis in clinical hyperthermia patients: preliminary results of a new technique.
Hsp-27 has no diagnostic or prognostic significance in prostate or bladder cancers.
HSP-27 protein expression in uveal melanoma: correlation with predicted survival.
HSP105 expression in oral squamous cell carcinoma: Correlation with clinicopathological features and outcomes.
Hsp110 and Grp170, members of the Hsp70 superfamily, bind to scavenger receptor-A and scavenger receptor expressed by endothelial cells-I.
Hsp110 over-expression increases the immunogenicity of the murine CT26 colon tumor.
HSP20 Exerts a Protective Effect on Preeclampsia by Regulating Function of Trophoblast Cells Via Akt Pathways.
Hsp27 Acts as a Master Molecular Chaperone and Plays an Essential Role in Hepatocellular Carcinoma Progression.
Hsp27 and Hsp60 in human submandibular salivary gland: Quantitative patterns in healthy and cancerous tissues with potential implications for differential diagnosis and carcinogenesis.
Hsp27 expression in neuroblastoma: correlation with disease stage.
HSP27 expression levels are associated with the sensitivity of hepatocellular carcinoma cells to 17-allylamino-17-demethoxygeldanamycin.
Hsp27 inhibition with OGX-427 sensitizes non-small cell lung cancer cells to erlotinib and chemotherapy.
HSP27 is a partner of JAK2-STAT5 and a potential therapeutic target in myelofibrosis.
HSP27 knockdown produces synergistic induction of apoptosis by HSP90 and kinase inhibitors in glioblastoma multiforme.
Hsp27 modulates p53 signaling and suppresses cellular senescence.
Hsp27 regulates EGF/?-catenin mediated epithelial to mesenchymal transition in prostate cancer.
Hsp27 silencing coordinately inhibits proliferation and promotes Fas-induced apoptosis by regulating the PEA-15 molecular switch.
HSP27, 70 and 90, anti-apoptotic proteins, in clinical cancer therapy (Review).
Hsp27-induced MMP-9 expression is influenced by the Src tyrosine protein kinase yes.
Hsp27: A novel therapeutic target for pediatric M4/M5 acute myeloid leukemia.
HSP32 and HSP90 Immunoexpression, in Relation to Kit Pattern, Grading, and Mitotic Count in Canine Cutaneous Mast Cell Tumors.
HSP40 Interacts with Pyruvate Kinase M2 and Regulates Glycolysis and Cell Proliferation in Tumor Cells.
Hsp40, a possible indicator for thermotolerance of murine tumour in vivo.
HSP47 as a possible marker for malignancy of tumors in vivo.
HSP47 contributes to angiogenesis by induction of CCL2 in bladder cancer.
HSP47 promotes metastasis of breast cancer by interacting with myosin IIA via the unfolded protein response transducer IRE1?.
Hsp60 and Hsp10 as Antitumor Molecular Agents.
Hsp60 and Hsp10 down-regulation predicts bronchial epithelial carcinogenesis in smokers with chronic obstructive pulmonary disease.
Hsp60 and human aging: Les liaisons dangereuses.
Hsp60 and IL-8 axis promotes apoptosis resistance in cancer.
HSP60 as a drug target.
Hsp60 chaperonin acts as barrier to pharmacologically induced oxidative stress mediated apoptosis in tumor cells with differential stress response.
Hsp60 exerts a tumor suppressor function by inducing cell differentiation and inhibiting invasion in hepatocellular carcinoma.
Hsp60 expression, new locations, functions and perspectives for cancer diagnosis and therapy.
HSP60 in cancer: a promising biomarker for diagnosis and a potentially useful target for treatment.
Hsp60 in inflamed muscle tissue is the target of regulatory autoreactive T cells in patients with juvenile dermatomyositis.
Hsp60 is actively secreted by human tumor cells.
HSP60 is transported through the secretory pathway of 3-MCA-induced fibrosarcoma tumour cells and undergoes N-glycosylation.
HSP60 overexpression increases the protein levels of the p110? subunit of  phosphoinositide 3-kinase and c-Myc.
Hsp60 Post-translational Modifications: Functional and Pathological Consequences.
Hsp60 regulation of tumor cell apoptosis.
HSP60 silencing promotes Warburg-like phenotypes and switches the mitochondrial function from ATP production to biosynthesis in ccRCC cells.
HSP60 Takes a Hit: Inhibition of Mitochondrial Protein Folding.
HSP60, a protein downregulated by IGFBP7 in colorectal carcinoma.
HSP60-knockdown suppresses proliferation in colorectal cancer cells via activating the adenine/AMPK/mTOR signaling pathway.
Hsp60-mediated T cell stimulation is independent of TLR4 and IL-12.
HSP60-regulated Mitochondrial Proteostasis and Protein Translation Promote Tumor Growth of Ovarian Cancer.
Hsp60: molecular anatomy and role in colorectal cancer diagnosis and treatment.
Hsp70 (HSP70A1A) downregulation enhances the metastatic ability of cancer cells.
HSP70 and ER expression in cervical intraepithelial neoplasia and cervical cancer.
Hsp70 and Hsp90 of E. coli Directly Interact for Collaboration in Protein Remodeling.
Hsp70 and Hsp90--a relay team for protein folding.
Hsp70 exerts oncogenic activity in the Apc mutant Min mouse model.
Hsp70 in cancer: back to the future.
Hsp70 in Liquid Biopsies-A Tumor-Specific Biomarker for Detection and Response Monitoring in Cancer.
HSP70 is required for the proper assembly of pericentriolar material and function of mitotic centrosomes.
HSP70 regulates Eg5 distribution within the mitotic spindle and modulates the cytotoxicity of Eg5 inhibitors.
Hsp70 silencing with siRNA in nanocarriers enhances cancer cell death induced by the inhibitor of Hsp90.
HSP70 vaccine in combination with gene therapy with plasmid DNA encoding sPD-1 overcomes immune resistance and suppresses the progression of pulmonary metastatic melanoma.
Hsp70, an immunological actor playing with the intracellular self under oxidative stress.
Hsp70--a biomarker for tumor detection and monitoring of outcome of radiation therapy in patients with squamous cell carcinoma of the head and neck.
Hsp70-2 is required for tumor cell growth and survival.
HSP70/HSF1 axis, regulated via a PI3K/AKT pathway, is a druggable target in chronic lymphocytic leukemia.
HSP72 and gp96 in gastroenterological cancers.
Hsp72-mediated augmentation of MHC class I surface expression and endogenous antigen presentation.
Hsp90 activation and cell cycle regulation.
Hsp90 Activity Modulation by Plant Secondary Metabolites.
Hsp90 and angiogenesis in bone disorders--lessons from the avian growth plate.
Hsp90 and Cdc37 -- a chaperone cancer conspiracy.
Hsp90 and client protein maturation.
HSP90 and Co-chaperones: Impact on Tumor Progression and Prospects for Molecular-Targeted Cancer Therapy.
Hsp90 and environmental impacts on epigenetic states: a model for the trans-generational effects of diethylstibesterol on uterine development and cancer.
HSP90 and HSP70 are essential for stabilization and activation of the WASF3 metastasis promoting protein.
HSP90 and HSP70: Implication in Inflammation Processes and Therapeutic Approaches for Myeloproliferative Neoplasms.
HSP90 and Immune Modulation in Cancer.
HSP90 and the chaperoning of cancer.
Hsp90 and the Fanconi anemia pathway: a molecular link between protein quality control and the DNA damage response.
Hsp90 as a "Chaperone" of the Epigenome: Insights and Opportunities for Cancer Therapy.
Hsp90 as a gatekeeper of tumor angiogenesis: clinical promise and potential pitfalls.
HSP90 as a marker of progression in melanoma.
HSP90 as a new therapeutic target for cancer therapy: the story unfolds.
HSP90 as a platform for the assembly of more effective cancer chemotherapy.
Hsp90 as a therapeutic target in patients with oesophageal carcinoma.
Hsp90 as an anti-cancer target.
Hsp90 C-Terminal Inhibitors Exhibit Antimigratory Activity by Disrupting the Hsp90?/Aha1 Complex in PC3-MM2 Cells.
Hsp90 chaperone facilitates E2F1/2-dependent gene transcription in human breast cancer cells.
Hsp90 chaperones wild-type p53 tumor suppressor protein.
Hsp90 cleavage by an oxidative stress leads to its client proteins degradation and cancer cell death.
HSP90 expression and early recurrence in gastroenteropancreatic neuroendocrine tumors: Potential for a novel therapeutic target.
HSP90 expression and its association with wighteone metabolite response in HER2-positive breast cancer cells.
HSP90 expression: a new predictive factor for BCG response in stage Ta-T1 grade 3 bladder tumours.
Hsp90 facilitates acquired drug resistance of tumor cells through cholesterol modulation however independent of tumor progression.
Hsp90 globally targets paused RNA polymerase to regulate gene expression in response to environmental stimuli.
Hsp90 in Cancer: Transcriptional Roles in the Nucleus.
Hsp90 in the continuum of breast ductal carcinogenesis: Evaluation in precursors, preinvasive and ductal carcinoma lesions.
Hsp90 inhibition accelerates cell lysis. Anti-Hsp90 ribozyme reveals a complex mechanism of Hsp90 inhibitors involving both superoxide- and Hsp90-dependent events.
HSP90 Inhibition and Cellular Stress Elicits Phenotypic Plasticity in Hematopoietic Differentiation.
Hsp90 inhibition by NVP-AUY922 and NVP-BEP800 decreases migration and invasion of irradiated normoxic and hypoxic tumor cell lines.
Hsp90 inhibition by PU-H71 induces apoptosis through endoplasmic reticulum stress and mitochondrial pathway in cancer cells and overcomes the resistance conferred by Bcl-2.
Hsp90 inhibition depletes Chk1 and sensitizes tumor cells to replication stress.
Hsp90 inhibition differentially destabilises MAP kinase and TGF-beta signalling components in cancer cells revealed by kinase-targeted chemoproteomics.
Hsp90 inhibition disrupts JAK-STAT signaling and leads to reductions in splenomegaly in patients with myeloproliferative neoplasms.
HSP90 inhibition downregulates DNA replication and repair genes via E2F1 repression.
HSP90 Inhibition Enhances Cancer Immunotherapy by Modulating the Surface Expression of Multiple Immune Checkpoint Proteins.
HSP90 inhibition enhances cancer immunotherapy by upregulating interferon response genes.
Hsp90 inhibition in adrenocortical carcinoma: Limited drug synergism with mitotane.
Hsp90 inhibition increases p53 expression and destabilizes MYCN and MYC in neuroblastoma.
HSP90 inhibition induces cytotoxicity via down-regulation of Rad51 expression and DNA repair capacity in non-small cell lung cancer cells.
Hsp90 inhibition protects against inherited retinal degeneration.
Hsp90 Inhibition Reduces TLR5 Surface Expression and NF-?B Activation in Human Myeloid Leukemia THP-1 Cells.
HSP90 inhibition results in apoptosis of Philadelphia acute lymphoblastic leukaemia cells: an attractive prospect of new targeted agents.
Hsp90 Inhibition Results in Glucocorticoid Receptor Degradation in Association with Increased Sensitivity to Paclitaxel in Triple-Negative Breast Cancer.
HSP90 inhibition suppresses lipopolysaccharide-induced lung inflammation in vivo.
HSP90 Inhibition Suppresses PGE2 Production via Modulating COX-2 and 15-PGDH Expression in HT-29 Colorectal Cancer Cells.
Hsp90 inhibition transiently activates Src kinase and promotes Src-dependent Akt and Erk activation.
Hsp90 inhibition: elimination of shock and stress.
HSP90 inhibition: two-pronged exploitation of cancer dependencies.
Hsp90 inhibitor 17-AAG inhibits progression of LuCaP35 xenograft prostate tumors to castration resistance.
HSP90 inhibitor 17-AAG prevents apoptosis of cardiomyocytes via miR-93-dependent mitigation of endoplasmic reticulum stress.
Hsp90 inhibitor 17-AAG sensitizes Bcl-2 inhibitor (-)-gossypol by suppressing ERK-mediated protective autophagy and Mcl-1 accumulation in hepatocellular carcinoma cells.
HSP90 inhibitor 17-DMAG exerts anticancer effects against gastric cancer cells principally by altering oxidant-antioxidant balance.
Hsp90 inhibitor 17?AAG inhibits stem cell?like properties and chemoresistance in osteosarcoma cells via the Hedgehog signaling pathway.
HSP90 inhibitor antagonizing MIF: The specifics of pleiotropic cancer drug candidates.
Hsp90 inhibitor as a sensitizer of cancer cells to different therapies (review).
HSP90 inhibitor AUY922 can reverse Fulvestrant induced feedback reaction in human breast cancer cells.
HSP90 inhibitor CH5164840 induces micronuclei in TK6 cells via an aneugenic mechanism.
HSP90 inhibitor DPB induces autophagy and more effectively apoptosis in A549 cells combined with autophagy inhibitors.
HSP90 Inhibitor Encapsulated Photo-Theranostic Nanoparticles for Synergistic Combination Cancer Therapy.
HSP90 Inhibitor Ganetespib (STA-9090) Inhibits Tumor Growth in c-Myc-Dependent Esophageal Squamous Cell Carcinoma.
Hsp90 Inhibitor Ganetespib Sensitizes Non-Small Cell Lung Cancer to Radiation but Has Variable Effects with Chemoradiation.
Hsp90 inhibitor gedunin causes apoptosis in A549 lung cancer cells by disrupting Hsp90:Beclin-1:Bcl-2 interaction and downregulating autophagy.
Hsp90 inhibitor geldanamycin and its derivatives as novel cancer chemotherapeutic agents.
Hsp90 inhibitor geldanamycin enhances the antitumor efficacy of enediyne lidamycin in association with reduced DNA damage repair.
Hsp90 inhibitor induces autophagy and apoptosis in osteosarcoma cells.
Hsp90 inhibitor is a good candidate for effective combination therapy with carbon ions.
Hsp90 inhibitor NMS-E973 exerts the anticancer effect against glioblastoma via induction of PUMA-mediated apoptosis.
Hsp90 inhibitor NVP-AUY922 enhances radiation sensitivity of tumor cell lines under hypoxia.
Hsp90 inhibitor NVP-AUY922 enhances the radiation sensitivity of lung cancer cell lines with acquired resistance to EGFR-tyrosine kinase inhibitors.
HSP90 inhibitor NVP-AUY922 induces cell apoptosis by disruption of the survivin in papillary thyroid carcinoma cells.
HSP90 inhibitor PU-H71 increases radiosensitivity of breast cancer cells metastasized to visceral organs and alters the levels of inflammatory mediators.
Hsp90 inhibitor PU-H71, a multimodal inhibitor of malignancy, induces complete responses in triple-negative breast cancer models.
HSP90 Inhibitor SNX5422/2112 Targets the Dysregulated Signal and Transcription Factor Network and Malignant Phenotype of Head and Neck Squamous Cell Carcinoma.
Hsp90 Inhibitor STA9090 Sensitizes Hepatocellular Carcinoma to Hyperthermia-Induced DNA Damage by Suppressing DNA-PKcs Protein Stability and mRNA Transcription.
Hsp90 inhibitor, BIIB021, induces apoptosis and autophagy by regulating mTOR-Ulk1 pathway in imatinib-sensitive and -resistant chronic myeloid leukemia cells.
Hsp90 inhibitor-mediated disruption of chaperone association of ATR with hsp90 sensitizes cancer cells to DNA damage.
HSP90 Inhibitor-SN-38 Conjugate Strategy for Targeted Delivery of Topoisomerase I Inhibitor to Tumors.
Hsp90 inhibitors and drug resistance in cancer: The potential benefits of combination therapies of Hsp90 inhibitors and other anti-cancer drugs.
Hsp90 inhibitors and the reduction of anti-cancer drug resistance by non-genetic and genetic mechanisms.
Hsp90 inhibitors are efficacious against Kaposi Sarcoma by enhancing the degradation of the essential viral gene LANA, of the viral co-receptor EphA2 as well as other client proteins.
Hsp90 inhibitors as anti-cancer agents, from basic discoveries to clinical development.
Hsp90 inhibitors as novel cancer chemotherapeutic agents.
Hsp90 inhibitors as promising agents for radiotherapy.
Hsp90 inhibitors as selective anticancer drugs.
HSP90 inhibitors as therapy for multiple myeloma.
Hsp90 inhibitors attenuate effect of dexamethasone on activated NF-kappaB and AP-1.
Hsp90 inhibitors cause G2/M arrest associated with the reduction of Cdc25C and Cdc2 in lung cancer cell lines.
Hsp90 inhibitors deplete key anti-apoptotic proteins in pediatric solid tumor cells and demonstrate synergistic anticancer activity with cisplatin.
Hsp90 inhibitors disrupt mitochondrial homeostasis in cancer cells.
HSP90 inhibitors enhance differentiation and MITF (microphthalmia transcription factor) activity in osteoclast progenitors.
HSP90 Inhibitors for Cancer Therapy and Overcoming Drug Resistance.
Hsp90 Inhibitors in Parasitic Nematodes: Prospects and Challenges.
HSP90 inhibitors induce desensitization of EGF receptor via p38 MAPK-mediated phosphorylation at Ser1046/1047 in human pancreatic cancer cells.
Hsp90 Inhibitors NVP-AUY922 and NVP-BEP800 May Exert a Significant Radiosensitization on Tumor Cells along with a Cell Type-Specific Cytotoxicity.
Hsp90 inhibitors promote p53-dependent apoptosis through PUMA and Bax.
Hsp90 inhibitors suppress P53 phosphorylation in LPS - induced endothelial inflammation.
Hsp90 inhibitors, GA and 17AAG, lead to ER stress-induced apoptosis in rat histiocytoma.
Hsp90 inhibitors: clinical development and future opportunities in oncology therapy.
HSP90 Inhibitors: Current Development and Potential in Cancer Therapy.
HSP90 inhibitors: multi-targeted antitumor effects and novel combinatorial therapeutic approaches in cancer therapy.
Hsp90 inhibitors: small molecules that transform the Hsp90 protein folding machinery into a catalyst for protein degradation.
HSP90 inhibits apoptosis and promotes growth by regulating HIF-1? abundance in hepatocellular carcinoma.
Hsp90 interacts with AMPK and mediates acetyl-CoA carboxylase phosphorylation.
HSP90 is a key for telomerase activation and malignant transition in pheochromocytoma.
Hsp90 Is a Novel Target Molecule of CDDO-Me in Inhibiting Proliferation of Ovarian Cancer Cells.
HSP90 is a promising target in gemcitabine and 5-fluorouracil resistant pancreatic cancer.
HSP90 is a therapeutic target in JAK2-dependent myeloproliferative neoplasms in mice and humans.
Hsp90 is an essential regulator of EphA2 receptor stability and signaling: implications for cancer cell migration and metastasis.
HSP90 is essential for Jak-STAT signaling in classical Hodgkin lymphoma cells.
Hsp90 is essential for restoring cellular functions of temperature-sensitive p53 mutant protein but not for stabilization and activation of wild-type p53: implications for cancer therapy.
Hsp90 is expressed and represents a therapeutic target in human oesophageal cancer using the inhibitor 17-allylamino-17-demethoxygeldanamycin.
HSP90 modulates actin dynamics: Inhibition of HSP90 leads to decreased cell motility and impairs invasion.
Hsp90 modulates CAG repeat instability in human cells.
Hsp90 molecular chaperone inhibitors: are we there yet?
HSP90 Molecular Chaperones, Metabolic Rewiring, and Epigenetics: Impact on Tumor Progression and Perspective for Anticancer Therapy.
Hsp90 N- and C-terminal double inhibition synergistically suppresses Bcr-Abl-positive human leukemia cells.
Hsp90 phosphorylation, Wee1, and the cell cycle.
HSP90 promotes cell glycolysis, proliferation and inhibits apoptosis by regulating PKM2 abundance via Thr-328 phosphorylation in hepatocellular carcinoma.
HSP90 proteins in the scenario of tumor complexity.
Hsp90 regulates autophagy and plays a role in cancer therapy.
Hsp90 regulates HDAC3-dependent gene transcription while HDAC3 regulates the functions of Hsp90.
Hsp90 rescues PTK6 from proteasomal degradation in breast cancer cells.
Hsp90 structure and function studied by NMR spectroscopy.
HSP90 supports tumor growth and angiogenesis through PRKD2 protein stabilization.
Hsp90, an unlikely ally in the war on cancer.
Hsp90, the concertmaster: tuning transcription.
Hsp90-binding immunophilin FKBP51 forms complexes with hTERT enhancing telomerase activity.
Hsp90-dependent activation of protein kinases is regulated by chaperone-targeted dephosphorylation of Cdc37.
Hsp90-peptide complexes stimulate antigen presentation through the class II pathway after binding scavenger receptor SREC-I.
Hsp90-stabilized MIF supports tumor progression via macrophage recruitment and angiogenesis in colorectal cancer.
Hsp90-targeted miRNA-liposomal formulation for systemic antitumor effect.
HSP90/AXL/eIF4E-regulated unfolded protein response as an acquired vulnerability in drug-resistant KRAS-mutant lung cancer.
Hsp90: a chaperone for HIV-1.
Hsp90: a chaperone for protein folding and gene regulation.
Hsp90: a drug target?
Hsp90: A Global Regulator of the Genotype-to-Phenotype Map in Cancers.
Hsp90: a novel target for cancer therapy.
Hsp90: a novel target for the disruption of multiple signaling cascades.
HSP90: a promising broad-spectrum antiviral drug target.
HSP90: a rising star on the horizon of anticancer targets.
Hsp90: an emerging target for breast cancer therapy.
Hsp90: breaking the symmetry.
HSP90: Chaperone-me-not.
Hsp90: the vulnerable chaperone.
Hsp90? interacts with MDM2 to suppress p53-dependent senescence during skeletal muscle regeneration.
Hsp90? promoted endothelial cell-dependent tumor angiogenesis in hepatocellular carcinoma.
Hsp90? promotes aggressive vasculogenic mimicry via epithelial-mesenchymal transition in hepatocellular carcinoma.
HSP90A inhibition promotes anti-tumor immunity by reversing multi-modal resistance and stem-like property of immune-refractory tumors.
Hsp90B enhances MAST1-mediated cisplatin resistance by protecting MAST1 from proteosomal degradation.
HSP90B1 overexpression predicts poor prognosis in NSCLC patients.
HSPA1A, HSPA1L and TRAP1 heat shock genes may be associated with prognosis in ovarian epithelial cancer.
HSPA1L Enhances Cancer Stem Cell-Like Properties by Activating IGF1R? and Regulating ?-Catenin Transcription.
HSPA9 overexpression inhibits apoptin-induced apoptosis in the HepG2 cell line.
HSPB1 as a novel regulator of ferroptotic cancer cell death.
Human colon cancer cells differ in their sensitivity to curcumin-induced apoptosis and heat shock protects them by inhibiting the release of apoptosis-inducing factor and caspases.
Human gamma delta T cells recognize heat shock protein-60 on oral tumor cells.
Human Genetic Relevance and Potent Antitumor Activity of Heat Shock Protein 90 Inhibition in Canine Lung Adenocarcinoma Cell Lines.
Human heat shock protein 70 (Hsp70) as a peripheral membrane protein.
Human Heat Shock Protein 70 Enhances Tumor Antigen Presentation through Complex Formation and Intracellular Antigen Delivery without Innate Immune Signaling.
Human Hsp60 with its mitochondrial import signal occurs in solution as heptamers and tetradecamers remarkably stable over a wide range of concentrations.
Human major histocompatibility complex contains a minimum of 19 genes between the complement cluster and HLA-B.
Human major histocompatibility complex contains genes for the major heat shock protein HSP70.
Human meningiomas: immunohistochemical localization of progesterone receptor and heat shock protein 27 and absence of estrogen receptor and PS2.
Human mitochondrial Hsp70 (mortalin): shedding light on ATPase activity, interaction with adenosine nucleotides, solution structure and domain organization.
Human mortalin (HSPA9): a candidate for the myeloid leukemia tumor suppressor gene on 5q31.
Human papillomavirus E6: Host cell receptor, GRP78, binding site prediction.
Human T cell leukemia virus type 1 Tax associates with a molecular chaperone complex containing hTid-1 and Hsp70.
Humanization of a mouse monoclonal antibody directed against a cell surface-exposed epitope of membrane-associated heat shock protein 70 (Hsp70).
Hybrid Nanoparticles Modified by Hyaluronic Acid Loading an HSP90 Inhibitor as a Novel Delivery System for Subcutaneous and Orthotopic Colon Cancer Therapy.
Hydrating for resistance to radicicol.
Hydroximic Acid Derivatives: Pleiotrophic Hsp Co-Inducers Restoring Homeostasis and Robustness.
Hyperthermia by near infrared radiation induced immune cells activation and infiltration in breast tumor.
Hyperthermia enhances 17-DMAG efficacy in hepatocellular carcinoma cells with aggravated DNA damage and impaired G2/M transition.
Hypo-fractionated Radiation, Magnetic Nanoparticle Hyperthermia and a Viral Immunotherapy Treatment of Spontaneous Canine Cancer.
Hypoxia attenuates Hsp90 inhibitor 17-DMAG-induced cyclin B1 accumulation in hepatocellular carcinoma cells.
Hypoxia Enhances Lysophosphatidic Acid Responsiveness in Ovarian Cancer Cells and Lysophosphatidic Acid Induces Ovarian Tumor Metastasis In vivo.
Hypoxia upregulates Hsp90? expression via STAT5b in cancer cells.
Identification and characterisation of a novel heat shock protein 90 inhibitor ONO4140.
Identification and characterization of a 66-68-kDa protein as a methotrexate-binding protein in murine leukemia L1210 cells.
Identification and characterization of molecular interactions between mortalin/mtHsp70 and HSP60.
Identification and Characterization of MortaparibPlus-A Novel Triazole Derivative That Targets Mortalin-p53 Interaction and Inhibits Cancer-Cell Proliferation by Wild-Type p53-Dependent and -Independent Mechanisms.
Identification and Comparison of Differentiation-Related Proteins in Hepatocellular Carcinoma Tissues by Proteomics.
Identification and functional characterization of nuclear mortalin in human carcinogenesis.
Identification and Structure-Activity Studies of 1,3-Dibenzyl-2-aryl imidazolidines as Novel Hsp90 Inhibitors.
Identification of a new scaffold for hsp90 C-terminal inhibition.
Identification of a new series of potent diphenol HSP90 inhibitors by fragment merging and structure-based optimization.
Identification of a protein with homology to hsp90 that binds the type 1 tumor necrosis factor receptor.
Identification of an allosteric pocket on human hsp70 reveals a mode of inhibition of this therapeutically important protein.
Identification of an HSP90 modulated multi-step process for ERBB2 degradation in breast cancer cells.
Identification of brain-derived neurotrophic factor as a novel functional protein in hepatocellular carcinoma.
Identification of breast cancer metastasis-associated proteins in an isogenic tumor metastasis model using two-dimensional gel electrophoresis and liquid chromatography-ion trap-mass spectrometry.
Identification of DU 145 prostate cancer cell proteins that bind to the carboxy-terminal peptide of human PTHrP in vitro.
Identification of epipolythiodioxopiperazines HDN-1 and chaetocin as novel inhibitor of heat shock protein 90.
Identification of GRP75 as an independent favorable prognostic marker of neuroblastoma by a proteomics analysis.
Identification of heat shock protein 90 and other proteins as tumour antigens by serological screening of an ovarian carcinoma expression library.
Identification of Heat Shock Protein 90 as a Recurrence Related Marker in Juvenile Nasopharyngeal Angiofibroma.
Identification of heat shock protein 90 inhibitors to sensitize drug resistant side population tumor cells using a cell based assay platform.
Identification of HLA-A2 or HLA-A24-restricted CTL epitopes for potential HSP105-targeted immunotherapy in colorectal cancer.
Identification of Inhibitors of HSF1 Functional Activity by High-Content Target-Based Screening.
Identification of Isoform-Selective Ligands for the Middle Domain of Heat Shock Protein 90 (Hsp90).
Identification of Limonol Derivatives as Heat Shock Protein?90 (Hsp90) Inhibitors through a Multidisciplinary Approach.
Identification of low-abundance proteins in serum via the isolation of HSP72 complexes.
Identification of metastasis-related proteins and their clinical relevance to triple-negative human breast cancer.
Identification of miPEP133 as a novel tumor-suppressor microprotein encoded by miR-34a pri-miRNA.
Identification of mixed lineage leukemia 1(MLL1) protein as a coactivator of heat shock factor 1(HSF1) protein in response to heat shock protein 90 (HSP90) inhibition.
Identification of molecular markers for the oncogenic differentiation of hepatocellular carcinoma.
Identification of mRNAs differentially expressed in lymphocytes following interleukin-2 activation.
Identification of new biomarkers for clinical trials of Hsp90 inhibitors.
Identification of New Hsp90 Inhibitors: Structure Based Virtual Screening, Molecular Dynamic Simulation, Synthesis and Biological Evaluation.
Identification of Novel Interaction Partners of AIF Protein on the Outer Mitochondrial Membrane.
Identification of Novel Response and Predictive Biomarkers to Hsp90 Inhibitors Through Proteomic Profiling of Patient-derived Prostate Tumor Explants.
Identification of potent water soluble purine-scaffold inhibitors of the heat shock protein 90.
Identification of Potential Anticancer Protein Targets in Cytotoxicity Mediated by Tropical Medicinal Fern Extracts.
Identification of squamous cell carcinoma associated proteins by proteomics and loss of beta tropomyosin expression in esophageal cancer.
Identification of the circRNA-miRNA-mRNA regulatory network of Hsp90 inhibitor-induced cell death in colorectal cancer by integrated analysis.
Identification of the naphthoquinone derivative inhibitors binding site in heat shock protein 90: an induced-fit docking, molecular dynamics and 3D-QSAR study.
Identification of the peptide-binding site in the heat shock chaperone/tumor rejection antigen gp96 (Grp94).
Identification of the phosphorylation sites of the murine small heat shock protein hsp25.
Identification of the plant compound geraniin as a novel hsp90 inhibitor.
Identification of the Transmembrane Glucose Regulated Protein 78 as a Biomarker for the Brain Cancer Glioblastoma Multiforme by Gene Expression and Proteomic Studies.
Identification of TPD52 and DNAJB1 as two novel bile biomarkers for cholangiocarcinoma by iTRAQ?based quantitative proteomics analysis.
Identification of Tumor Antigen AF20 as Glycosylated Transferrin Receptor 1 in Complex with Heat Shock Protein 90 and/or Transporting ATPase.
Identification of tumor antigens that elicit a humoral immune response in breast cancer patients' sera by serological proteome analysis (SERPA).
Identification of tumor necrosis factor signaling-related proteins during Epstein-Barr virus-induced B cell transformation.
Identification, design and bio-evaluation of novel Hsp90 inhibitors by ligand-based virtual screening.
Identifications small molecules inhibitor of p53-mortalin complex for cancer drug using virtual screening.
Ifosfamide induced stress response in human lymphocytes.
IgA antibodies to the 27-kDa heat-shock protein in the genital tracts of women with gynecologic cancers.
IGFBP2 plays an important role in heat shock protein 27-mediated cancer progression and metastasis.
IKK{gamma} protein is a target of BAG3 regulatory activity in human tumor growth.
IL-6 activated JAK/STAT3 pathway and sensitivity to Hsp90 inhibitors in multiple myeloma.
Image-guided photo-therapeutic nanoporphyrin synergized HSP90 inhibitor in patient-derived xenograft bladder cancer model.
Image-Guided Radiofrequency Hyperthermia (RFH)-Enhanced Direct Chemotherapy of Hepatic Tumors: The Underlying Biomolecular Mechanisms.
Imaging Mass Spectrometry and Proteome Analysis of Marek's Disease Virus-Induced Tumors.
Imaging of Firefly Luciferase Activity under Antiangiogenic Therapy in a Heat Shock Protein 70-Transfected Melanoma Tumor Model.
Immortal and mortal clonal lymphocyte lines from channel catfish: comparison of telomere length, telomerase activity, tumor suppressor and heat shock protein expression.
Immune expression and inhibition of heat shock protein 90 in uveal melanoma.
Immune mechanism of the antitumor effects generated by bortezomib.
Immune response to p53 is dependent upon p53/HSP70 complexes in breast cancers.
Immunization of cancer patients with autologous cancer-derived heat shock protein gp96 preparations: a pilot study.
Immunization with a recombinant GnRH vaccine conjugated to heat shock protein 65 inhibits tumor growth in orthotopic prostate cancer mouse model.
Immunization with a recombinant GnRH vaccine fused to heat shock protein 65 inhibits mammary tumor growth in vivo.
Immunization with heat shock protein 105-pulsed dendritic cells leads to tumor rejection in mice.
Immunization with heat shock protein 70 from methylcholanthrene-induced sarcomas induces tumor protection correlating with in vitro T cell responses.
Immuno-hyperthermia effected by antibody-conjugated nanoparticles selectively targets and eradicates individual cancer cells.
Immunocytochemical accumulation of p53 in corticotroph adenomas: relationship with heat shock proteins and apoptosis.
Immunoelectron microscopy provides evidence for the presence of mitochondrial heat shock 10-kDa protein (chaperonin 10) in red blood cells and a variety of secretory granules.
Immunoexpression patterns for Hypoxia-inducible Factor-1? and von Hippel-Lindau protein, in relation to Hsp90, of human brain tumors.
Immunogenic hsp-70 is overexpressed in colorectal cancers with high-degree microsatellite instability.
Immunogenic potential of three transmissible venereal tumor cell lysates to prime canine-dendritic cells for cancer immunotherapy.
Immunohistochemical Analysis of Expressions of RB1, CDK4, HSP90, cPLA2G4A, and CHMP2B Is Helpful in Distinction between Myxofibrosarcoma and Myxoid Liposarcoma.
Immunohistochemical detection of estrogen receptor in invasive human breast cancer: correlation with heat shock proteins, pS2 and oncogene products.
Immunohistochemical detection of HSP27 and hnRNP K as prognostic and predictive biomarkers for colorectal cancer.
Immunohistochemical detection of HSP60-expression in human ovarian cancer. Correlation with survival in a series of 247 patients.
Immunohistochemical detection of the 150-kDa oxygen-regulated protein in bladder cancer.
Immunohistochemical distribution of heat shock protein 47 (HSP47) in scirrhous carcinoma of the stomach.
Immunohistochemical evaluation of expression of heat shock proteins HSP70 and HSP90 in mammary gland neoplasms in bitches.
Immunohistochemical Evaluation of Heat Shock Protein Expression in Normal Canine Nerve and Peripheral Nerve Sheath Tumours.
Immunohistochemical evaluation of heat shock proteins in normal and preinvasive lesions of the cervix.
Immunohistochemical expression of Hsp60 correlates with tumor progression and hormone resistance in prostate cancer.
Immunohistochemical study of heat shock proteins 27, 60 and 70 in the normal human adrenal and in adrenal tumors with suppressed ACTH production.
Immunohistochemical tumour markers in endometrial carcinoma.
Immunohistochemical validation of a novel epithelial and a novel stromal marker of pancreatic ductal adenocarcinoma identified by global expression microarrays: sea urchin fascin homolog and heat shock protein 47.
Immunohistochemistry of human Hsp60 in health and disease: from autoimmunity to cancer.
Immunohistochemistry of Human Hsp60 in Health and Disease: From Autoimmunity to Cancer.
Immunolocalisation of heat shock protein 72 and glycoprotein 96 in colonic adenocarcinoma.
Immunomodulating activity of mycobacterial heat shock protein 65 in tumor cells.
Immunomodulation by MYB is associated with tumor relapse in patients with early stage colorectal cancer.
Immunopathogenic consequences of Chlamydia trachomatis 60 kDa heat shock protein expression in the female reproductive tract.
Immunoprotective activities of multiple chaperone proteins isolated from murine B-cell leukemia/lymphoma.
Immunotherapeutic targeting of membrane hsp70-expressing tumors using recombinant human granzyme B.
Immunotherapy of a human papillomavirus (HPV) type 16 E7-expressing tumour by administration of fusion protein comprising Mycobacterium bovis bacille Calmette-Guérin (BCG) hsp65 and HPV16 E7.
Immunotherapy of cancer using heat shock proteins.
Immunotherapy of radioresistant mammary tumors with early metastasis using molecular chaperone vaccines combined with ionizing radiation.
Immunotherapy of tumors with autologous tumor-derived heat shock protein preparations.
Impact of butyrate on PKM2 and HSP90? expression in human colon tissues of different transformation stages: a comparison of gene and protein data.
Impact of heat-shock protein 90 on cancer metastasis.
Impact of nitrite exposure on plasma biochemical parameters and immune-related responses in Takifugu rubripes.
Impact of Posttranslational Modifications on the Anticancer Activity of Hsp90 Inhibitors.
Impairment of Membrane Lipid Homeostasis by Bichalcone Analog TSWU-BR4 Attenuates Function of GRP78 in Regulation of the Oxidative Balance and Invasion of Cancer Cells.
Implication of Heat Shock Protein 90 (HSP90) in Tumor Angiogenesis: A Molecular Target for Anti-Angiogenic Therapy?
Implication of heat shock proteins in rotavirus entry into Reh cells.
Implication of PBP74/mortalin/GRP75 in the radio-adaptive response.
Improvement of inhibitor identification for heat shock protein 90? by utilizing a red-shifted fluorescence polarization probe.
Improvements in the growth performance, immunity, disease resistance, and gut microbiota by the probiotic Rummeliibacillus stabekisii in Nile tilapia (Oreochromis niloticus).
Improving the Hsp90 Inhibitors Containing 4-(2,4-Dihydroxyphenyl)-1,2,3-thiadiazole Scaffold: Synthesis, Affinity and Effect on Cancer Cells.
Improving the outcome of patients with castration-resistant prostate cancer through rational drug development.
In silico Analysis of Molecular Mechanisms of Galanthus nivalis Agglutinin-Related Lectin-Induced Cancer Cell Death from Carbohydrate-Binding Motif Evolution Hypothesis.
In silico analysis of the binding properties of solasonine to mortalin and p53, and in vitro pharmacological studies of its apoptotic and cytotoxic effects on human HepG2 and Hep3b hepatocellular carcinoma cells.
In silico design novel Vibsanin B derivatives as inhibitor for heat shock protein 90 based on 3D-QSAR, molecular docking and molecular dynamics simulation.
In silico design of small peptide-based Hsp90 inhibitor: A novel anticancer agent.
In silico evaluation of drugs used in treatment of oral lichen planus.
In silico identification of potential Hsp90 inhibitors via ensemble docking, DFT and molecular dynamics simulations.
In silico screening and exploration into phenotypic alterations of deleterious oncogenic single nucleotide polymorphisms in HSPB1 gene.
In vitro and in vivo efficacy of heat shock protein specific immunotoxins on human tumor cells.
In vitro biological characterization of a novel, synthetic diaryl pyrazole resorcinol class of heat shock protein 90 inhibitors.
In Vitro Inhibition of Hsp90 Protein by Benzothiazoloquinazolinequinones Is Enhanced in The Presence of Ascorbate. A Preliminary In Vivo Antiproliferative Study.
In Vitro Metabolism of BIIB021, an Inhibitor of Heat Shock Protein 90, in Liver Microsomes and Hepatocytes of Rats, Dogs, and Humans and Recombinant Human Cytochrome P450 Isoforms.
In vivo imaging of CT26 mouse tumors by using cmHsp70.1 monoclonal antibody.
In Vivo Method to Monitor Changes in HER2 Expression Using Near-Infrared Fluorescence Imaging.
In vivo method to monitor changes in HER2 expression using near-infrared fluorescence imaging.
In vivo production of heat shock protein in mouse peritoneal macrophages by administration of lipopolysaccharide.
In vivo-in vitro correlation of antitumor activity of heat shock protein 90 (HSP90) inhibitors with a pharmacokinetics/pharmacodynamics analysis using NCI-N87 xenograft mice.
In-vivo fluorescence lifetime imaging for monitoring the efficacy of the cancer treatment.
Inactivation of a redox-sensitive protein phosphatase during the early events of tumor necrosis factor/interleukin-1 signal transduction.
Increase in gene-transcript levels as indicators of up-regulation of the unfolded protein response in spontaneous canine tumors.
Increased antileukemic effects in human acute myeloid leukemia by combining HSP70 and HSP90 inhibitors.
Increased cytotoxicity of chronic hypoxic cells by molecular inhibition of GRP78 induction.
Increased expression of 70 kD heat shock protein in cultured primary human keratinocytes induced by human papillomavirus 16 E6/E7 gene.
Increased expression of co-chaperone HOP with HSP90 and HSC70 and complex formation in human colonic carcinoma.
Increased Expression of GRP78 in Recurrent GBM Patients.
Increased expression of HSP27 inhibits invasion and metastasis in human esophageal squamous cell carcinoma.
Increased expression of the major heat shock protein Hsp72 in human prostate carcinoma cells is dispensable for their viability but confers resistance to a variety of anticancer agents.
Increased inducible heat shock protein 72 expression associated with PBMC isolated from patients with haematological tumours.
Increased LAMP2A levels correlate with a shorter disease-free survival of HER2 negative breast cancer patients and increased breast cancer cell viability.
Increased production of tumor necrosis factor-alpha by peritoneal fluid mononuclear cells induced by 60-kDa heat shock protein in women with minimal to mild endometriosis.
Increased radiosensitivity and radiothermosensitivity of human pancreatic MIA PaCa-2 and U251 glioblastoma cell lines treated with the novel Hsp90 inhibitor NVP-HSP990.
Increased sensitivity of human colon cancer cells to DNA cross-linking agents after GRP78 up-regulation.
Individual patient-specific immunity against high-grade glioma after vaccination with autologous tumor derived peptides bound to the 96 KD chaperone protein.
Indolyl-chalcone derivatives induce hepatocellular carcinoma cells apoptosis through oxidative stress related mitochondrial pathway in vitro and in vivo.
Inducible heat shock protein 70 expression as a potential predictive marker of metastasis in breast tumors.
Inducible heat shock protein 70 prevents multifocal flat dysplastic lesions and invasive tumors in an inflammatory model of colon cancer.
Inducible heat shock protein 70, interleukin-18, and tumor necrosis factor alpha correlate with outcomes in spontaneous intracerebral hemorrhage.
Inducible heat shock protein A1A (HSPA1A) is markedly expressed in rat myometrium by labour and secreted via myometrial cell-derived extracellular vesicles.
Inducible HSP70 antagonizes cisplatin?induced cell apoptosis through inhibition of the MAPK signaling pathway in HGC?27 cells.
Inducible Hsp70 as target of anticancer immunotherapy: Identification of HLA-A*0201-restricted epitopes.
Inducible knockout of GRP78/BiP in the hematopoietic system suppresses Pten-null leukemogenesis and AKT oncogenic signaling.
Inducing apoptosis of cancer cells using small-molecule plant compounds that bind to GRP78.
Induction of angiogenesis by heat shock protein 90 mediated by protein kinase Akt and endothelial nitric oxide synthase.
Induction of apoptosis by luteolin involving akt inactivation in human 786-o renal cell carcinoma cells.
Induction of apoptosis by phenylisocyanate derivative of quercetin: involvement of heat shock protein.
Induction of autologous tumor killing by heat treatment of fresh human tumor cells: involvement of gamma delta T cells and heat shock protein 70.
Induction of cyclooxygenase-2 by heat shock protein 60 in macrophages and endothelial cells.
Induction of glucose-regulated protein 78 by chronic hypoxia in human gastric tumor cells through a protein kinase C-epsilon/ERK/AP-1 signaling cascade.
Induction of Heat Shock Protein 70 as a Predictive Marker of the Tumor Cell Radiosensitization with Inhibitors of the Heat Shock Protein 90 Activity.
Induction of heat shock protein 72 synthesis by endogenous tumor necrosis factor via enhancement of the heat shock element-binding activity of heat shock factor 1.
Induction of heat shock protein HSPA6 (HSP70B') upon HSP90 inhibition in cancer cell lines.
Induction of heat shock protein synthesis in murine tumors during the development of thermotolerance.
Induction of heat shock proteins by heregulin beta1 leads to protection from apoptosis and anchorage-independent growth.
Induction of HITS, a newly identified family with sequence similarity 107 protein (FAM107B), in cancer cells by heat shock stimulation.
Induction of Hsp70 in tumor cells treated with inhibitors of the Hsp90 activity: A predictive marker and promising target for radiosensitization.
Induction of Hsp90 protein expression in malignant melanomas and melanoma metastases.
Induction of human hsp60 expression in monocytic cell lines.
Induction of leukemia-specific antibodies by immunotherapy with leukemia-cell-derived heat shock protein 70.
Induction of multiple CD8+ T cell responses against the inducible Hsp70 employing an Hsp70 oligoepitope peptide.
Induction of mutant p53-dependent apoptosis in human hepatocellular carcinoma by targeting stress protein mortalin.
Induction of nitric oxide synthase-dependent telomere shortening after functional inhibition of Hsp90 in human tumor cells.
Induction of novel Grp75 isoforms by 2-deoxyglucose in human and murine fibroblasts.
Induction of premature senescence by hsp90 inhibition in small cell lung cancer.
Induction of Senescence in Cancer Cells by a Novel Combination of Cucurbitacin B and Withanone: Molecular Mechanism and Therapeutic Potential.
Induction of synthesis of heat shock protein 72 in tumor necrosis factor gene-transduced cells.
Induction of systemic antitumor immunity by gene transfer of mammalian heat shock protein 70.1 into tumors in situ.
Induction of the hypoxia-inducible factor system by low levels of heat shock protein 90 inhibitors.
Induction of Tumor-specific Immune Response by Gene Transfer of Hsp70-cell-penetrating Peptide Fusion Protein to Tumors in Mice.
Inflammation is associated with progression of actinic keratoses to squamous cell carcinomas in humans.
Inflammation Profiling of Critically Ill Coronavirus Disease 2019 Patients.
Inflammation, genetics, and ischemic heart disease: focus on the major histocompatibility complex (MHC) genes.
Inflammation-Induced Citrullinated Glucose-Regulated Protein 78 Elicits Immune Responses in Human Type 1 Diabetes.
Inflammation-induced protein carbonylation contributes to poor prognosis for cholangiocarcinoma.
Inflammatory injury and mitophagy induced by Cr(VI) in chicken liver.
Influence of drug-induced apoptotic death on processing and presentation of tumor antigens by dendritic cells.
Influence of ezrin-shRNA in combination with HSP70 on the apoptosis and proliferation of osteosarcoma cells.
Influence of sex on cytokines, heat shock protein and oxidative stress markers in response to an acute total body resistance exercise protocol.
Influenza virus infection elicits protective antibodies and T cells specific for host cell antigens also expressed as tumor-associated antigens: a new view of cancer immunosurveillance.
Inhibiting HSP90 to treat cancer: a strategy in evolution.
Inhibiting lysine 353 oxidation of GRP78 by a hypochlorous probe targeting endoplasmic reticulum promotes autophagy in cancer cells.
Inhibiting protein-protein interactions of Hsp90 as a novel approach for targeting cancer.
Inhibiting the HSP90 chaperone destabilizes macrophage migration inhibitory factor and thereby inhibits breast tumor progression.
Inhibiting the HSP90 chaperone slows cyst growth in a mouse model of autosomal dominant polycystic kidney disease.
Inhibiting the molecular evolution of cancer through HSP90.
Inhibition effects on liver tumors of BALB/c mice bearing H22 cells by immunization with a recombinant immunogen of GnRH linked to heat shock protein 65.
Inhibition of ALK, PI3K/MEK and HSP90 in Murine Lung Adenocarcinoma Induced by EML4-ALK Fusion Oncogene.
Inhibition of Androgen Receptor Expression with Small Interfering RNA Enhances Cancer Cell Apoptosis by Suppressing Survival Factors in Androgen Insensitive, Late Stage LNCaP Cells.
Inhibition of Cancer Cell Growth by GRP78 siRNA Lipoplex via Activation of Unfolded Protein Response.
Inhibition of Cancer Invasion and Metastasis by Targeting the Molecular Chaperone Heat-shock Protein 90.
Inhibition of constitutive and cxc-chemokine-induced NF-kappaB activity potentiates ansamycin-based HSP90-inhibitor cytotoxicity in castrate-resistant prostate cancer cells.
Inhibition of endoplasmic reticulum chaperone protein glucose-regulated protein 78 potentiates anti-angiogenic therapy in renal cell carcinoma through inactivation of the PERK/eIF2? pathway.
Inhibition of endoplasmic-reticulum-stress-mediated autophagy enhances the effectiveness of chemotherapeutics on pancreatic cancer.
Inhibition of Established Micrometastases by Targeted Drug Delivery via Cell Surface Associated GRP78.
Inhibition of gastric tumor growth by a novel Hsp90 inhibitor.
Inhibition of heat shock induction of heat shock protein 70 and enhancement of heat shock protein 27 phosphorylation by quercetin derivatives.
Inhibition of heat shock protein (Hsp) 27 potentiates the suppressive effect of Hsp90 inhibitors in targeting breast cancer stem-like cells.
Inhibition of heat shock protein (Hsp) 90 potentiates the antiproliferative and pro-apoptotic effects of 2-(4'fluoro-phenylamino)-4H-1,3-thiazine[6,5-b]indole in A2780cis cells.
Inhibition of heat shock protein (HSP) 90 reverses signal transducer and activator of transcription (STAT) 3-mediated muscle wasting in cancer cachexia mice.
Inhibition of heat shock protein 27 (HspB1) tumorigenic functions by peptide aptamers.
Inhibition of heat shock protein 90 (HSP90) as a therapeutic strategy for the treatment of myeloma and other cancers.
Inhibition of Heat Shock Protein 90 as a Novel Platform for the Treatment of Cancer.
Inhibition of heat shock protein 90 decreases ACTH production and cell proliferation in AtT-20 cells.
Inhibition of heat shock protein 90 exerts an antitumour effect in angiosarcoma: involvement of the vascular endothelial growth factor signalling pathway.
Inhibition of heat shock protein 90 function by 17-allylamino-17-demethoxy-geldanamycin in Hodgkin's lymphoma cells down-regulates Akt kinase, dephosphorylates extracellular signal-regulated kinase, and induces cell cycle arrest and cell death.
Inhibition of heat shock protein 90 function down-regulates Akt kinase and sensitizes tumors to Taxol.
Inhibition of heat shock protein 90 impairs epidermal growth factor-mediated signaling in gastric cancer cells and reduces tumor growth and vascularization in vivo.
Inhibition of heat shock protein 90 sensitizes melanoma cells to thermosensitive ferromagnetic particle-mediated hyperthermia with low Curie temperature.
Inhibition of heat shock protein 90 suppresses squamous carcinogenic progression in a mouse model of esophageal cancer.
Inhibition of Heat Shock Protein 90 suppresses TWIST1 Transcription.
Inhibition of Heat Shock Protein 90 with AUY922 Represses Tumor Growth in a Transgenic Mouse Model of Islet Cell Neoplasms.
Inhibition of heat shock protein-90 modulates multiple functions required for survival of human T-cell leukemia virus type I-infected T-cell lines and adult T-cell leukemia cells.
Inhibition of histone deacetylation and DNA methylation improves gene expression mediated by the adeno-associated virus/phage in cancer cells.
Inhibition of homologous recombination repair in irradiated tumor cells pretreated with Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin.
Inhibition of Hsp90 activates osteoclast c-Src signaling and promotes growth of prostate carcinoma cells in bone.
Inhibition of HSP90 and Activation of HSF1 Diminish Macrophage NLRP3 Inflammasome Activity in Alcohol-Associated Liver Injury.
Inhibition of HSP90 as a Strategy to Radiosensitize Glioblastoma: Targeting the DNA Damage Response and Beyond.
Inhibition of hsp90 compromises the DNA damage response to radiation.
Inhibition of HSP90 could be possible mechanism for anti-cancer property of amniotic membrane.
Inhibition of Hsp90 down-regulates mutant epidermal growth factor receptor (EGFR) expression and sensitizes EGFR mutant tumors to paclitaxel.
Inhibition of Hsp90 leads to cell cycle arrest and apoptosis in human malignant pleural mesothelioma.
Inhibition of HSP90 molecular chaperones: moving into the clinic.
Inhibition of HSP90 overcomes melphalan resistance through downregulation of Src in multiple myeloma cells.
Inhibition of Hsp90 Suppresses PI3K/AKT/mTOR Signaling and Has Antitumor Activity in Burkitt Lymphoma.
Inhibition of Hsp90 via 17-DMAG induces apoptosis in a p53-dependent manner to prevent medulloblastoma.
Inhibition of HSP90 with AUY922 Induces Synergy in HER2-Amplified Trastuzumab-Resistant Breast and Gastric Cancer.
Inhibition of Hsp90 with resorcylic acid macrolactones: synthesis and binding studies.
Inhibition of Hsp90: a multitarget approach to radiosensitization.
Inhibition of HSP90? Improves Lipid Disorders by Promoting Mature SREBPs Degradation via the Ubiquitin-proteasome System.
Inhibition of Mitochondrial Matrix Chaperones and Antiapoptotic Bcl-2 Family Proteins Empower Antitumor Therapeutic Responses.
Inhibition of mortalin expression reverses cisplatin resistance and attenuates growth of ovarian cancer cells.
Inhibition of NF-kappaB1 and NF-kappaB2 activation in prostate cancer cells treated with antibody against the carboxyl terminal domain of GRP78: effect of p53 upregulation.
Inhibition of succinate dehydrogenase by the mitochondrial chaperone TRAP1 has anti-oxidant and anti-apoptotic effects on tumor cells.
Inhibition of the Human Hsc70 System by Small Ligands as a Potential Anticancer Approach.
Inhibition of the mitochondrial Hsp90 chaperone network: A novel, efficient treatment strategy for cancer?
Inhibition of the serine/threonine protein phosphatases PP1 and PP2A in lymphocytes: effect on mRNA levels for interleukin-2, IL-2R alpha, krox-24, p53, hsc70 and cyclophilin.
Inhibition of tumor growth in mice with severe combined immunodeficiency is mediated by heat shock protein 70 (Hsp70)-peptide-activated, CD94 positive natural killer cells.
Inhibitor of heat-shock protein 90 enhances the antitumor effect of DNA vaccine targeting clients of heat-shock protein.
Inhibitors of deacetylases suppress oncogenic KIT signaling, acetylate HSP90, and induce apoptosis in gastrointestinal stromal tumors.
Inhibitors of HSP90 block p95-HER2 signaling in Trastuzumab-resistant tumors and suppress their growth.
Inhibitors of HSP90 in melanoma.
Inhibitors of the HSP90 molecular chaperone: attacking the master regulator in cancer.
Inhibitors of the HSP90 molecular chaperone: current status.
Inhibitory effect of Par-4 combined with cisplatin on human Wilms' tumor cells.
Inhibitory effect of STAT3 gene combined with CDDP on growth of human Wilms tumour SK-NEP-1 cells.
Inhibitory effects of heat shock protein 90 blockade on proinflammatory human Th1 and Th17 cell subpopulations.
Initial testing (stage 1) of ganetespib, an Hsp90 inhibitor, by the pediatric preclinical testing program.
Innate immunity meets with cellular stress at the IKK complex: Regulation of the IKK complex by HSP70 and HSP90.
Innate immunity protein Tag7 (PGRP-S) activates lymphocytes capable of Fasl-Fas-dependent contact killing of virus-infected cells.
Insights from yeast into whether the inhibition of heat shock transcription factor (Hsf1) by rapamycin can prevent the Hsf1 activation that results from treatment with an Hsp90 inhibitor.
Insights into designing the dual-targeted HER2/HSP90 inhibitors.
Instabilotyping reveals unique mutational spectra in microsatellite-unstable gastric cancers.
Insulin resistance contributes to multidrug resistance in HepG2 cells via activation of the PERK signaling pathway and upregulation of Bcl-2 and P-gp.
Insulin-degrading enzyme (IDE): a novel heat shock-like protein.
Integration of a porous coordination network and black phosphorus nanosheets for improved photodynamic therapy of tumor.
Integration of Gene Dosage and Gene Expression in Non-Small Cell Lung Cancer, Identification of HSP90 as Potential Target.
Interaction between GRP78 and IGFBP-3 Affects Tumourigenesis and Prognosis in Breast Cancer Patients.
Interaction between HSP60 and {beta}-catenin promotes metastasis.
Interaction between hsp70 and hsp40, eukaryotic homologues of DnaK and DnaJ, in human cells expressing mutant-type p53.
Interaction of hepatitis C virus core protein with Hsp60 triggers the production of reactive oxygen species and enhances TNF-alpha-mediated apoptosis.
Interaction of Marek's disease virus oncoprotein Meq with heat-shock protein 70 in lymphoid tumour cells.
Interaction of radicicol with members of the heat shock protein 90 family of molecular chaperones.
Interaction of the ARF tumor suppressor with cytosolic HSP70 contributes to its autophagy function.
Interaction of Toll-Like Receptors with the Molecular Chaperone Gp96 Is Essential for Its Activation of Cytotoxic T Lymphocyte Response.
Interaction with Ribosomal Proteins Accompanies Stress Induction of the Anticancer Metallodrug BOLD-100/KP1339 in the Endoplasmic Reticulum.
Interactions between Hsp90 and oncogenic viruses: implications for viral cancer therapeutics.
Interferon-gamma (IFN-gamma) and tumour necrosis factor-alpha (TNF-alpha) are necessary in the early stages of induction of CD4 and CD8 cytotoxic T cells by Mycobacterium leprae heat shock protein (hsp) 65 kD.
Interleukin 1 and tumor necrosis factor stimulate two novel protein kinases that phosphorylate the heat shock protein hsp27 and beta-casein.
Interleukin 1 and tumour necrosis factor increase phosphorylation of the small heat shock protein. Effects in fibroblasts, Hep G2 and U937 cells.
Interleukin-6, interleukin-10 and heat shock protein-90 expression in renal epithelial neoplasias and surrounding normal-appearing renal parenchyma.
INTERMITTENT AND SUSTAINED HYPOXIA INDUCE A SIMILAR GENE EXPRESSION PROFILE IN THE HUMAN AORTIC ENDOTHELIAL CELLS.
Intracellular trafficking and endocytic uptake pathway of Pepper vein banding virus-like particles in epithelial cells.
Intratumor injection of the Hsp90 inhibitor 17AAG decreases tumor growth and induces apoptosis in a prostate cancer xenograft model.
Intravenous Immunoglobulin G Suppresses Heat Shock Protein (HSP)-70 Expression and Enhances the Activity of HSP90 and Proteasome Inhibitors.
Intrinsic proteotoxic stress levels vary and act as a predictive marker for sensitivity of cancer cells to Hsp90 inhibition.
Introducing differential expression of human heat shock protein 27 in hepatocellular carcinoma: moving toward identification of cancer biomarker.
Intronic polymorphism (1541-1542delGT) of the constitutive heat shock protein 70 gene has functional significance and shows evidence of association with lung cancer risk.
Investigation into the potential for hypoxic interior of neoplasms to enhance HSPA expression in glioma.
Investigation of anticancer activities of STA-9090 (ganetespib) as a second generation HSP90 inhibitor in Saos-2 osteosarcoma cells.
Investigation of B,C-ring truncated deguelin derivatives as heat shock protein 90 (HSP90) inhibitors for use as anti-breast cancer agents.
Investigation of Thermally Induced Cellular Ablation and Heat Response Triggered by Planar MoS2-Based Nanocomposite.
Investigation on different chemical stability of mitochondrial Hsp60 and its precursor.
Involvement and Targeted Intervention of Mortalin-Regulated Proteome Phosphorylated-Modification in Hepatocellular Carcinoma.
Involvement of HSP90 in ischemic postconditioning-induced cardioprotection by inhibition of the complement system, JNK and inflammation.
Involvement of p38 mitogen-activated protein kinase in heat shock protein 27 induction in human neutrophils.
Involvement of PAR-4 in cannabinoid-dependent sensitization of osteosarcoma cells to TRAIL-induced apoptosis.
Involvement of peptide antigens in the cytotoxicity between 70-kDa heat shock cognate protein-like molecule and CD3+, CD4-, CD8-, TCR-alpha beta- killer T cells.
Involvement of the TRAP-1 homologue, Dd-TRAP1, in spore differentiation during Dictyostelium development.
Ion-permeable membrane for on-chip preconcentration and separation of cancer marker proteins.
Ionizing radiation improves glioma-specific targeting of superparamagnetic iron oxide nanoparticles conjugated with cmHsp70.1 monoclonal antibodies (SPION-cmHsp70.1).
IP6K2 is a client for HSP90 and a target for cancer therapeutics development.
IPI-504, a novel and soluble HSP-90 inhibitor, blocks the unfolded protein response in multiple myeloma cells.
Iron-oxide nanoparticles target intracellular HSP90 to induce tumor radio-sensitization.
Is the small heat shock protein alphaB-crystallin an oncogene?
Isoindoline scaffold-based dual inhibitors of HDAC6 and HSP90 suppressing the growth of lung cancer in vitro and in vivo.
Isolation and characterization of a novel GRP78-specific single-chain variable fragment (scFv) using ribosome display method.
Isolation and characterization of a novel nanobody for detection of GRP78 expressing cancer cells.
Isolation and characterization of a novel scFv antibody fragments specific for Hsp70 as a tumor biomarker.
Isolation of MHC class I-restricted tumor antigen peptide and its precursors associated with heat shock proteins hsp70, hsp90, and gp96.
Isotope tracing assisted metabolic profiling: Application to understanding HSP60 silencing mediated tumor progression.
Isoxazolo(aza)naphthoquinones: a new class of cytotoxic Hsp90 inhibitors.
Isthmin targets cell-surface GRP78 and triggers apoptosis via induction of mitochondrial dysfunction.
iTRAQ Quantitative Proteomic Comparison of Metastatic and Non-Metastatic Uveal Melanoma Tumors.
JNK pathway and heat shock response mediate the survival of C26 colon carcinoma bearing mice fed with the mushroom Pleurotus eryngii var. eryngii without affecting tumor growth or cachexia.
KDM5B demethylates H3K4 to recruit XRCC1 and promote chemoresistance.
KEGG-expressed genes and pathways in triple negative breast cancer: Protocol for a systematic review and data mining.
KF25706, a novel oxime derivative of radicicol, exhibits in vivo antitumor activity via selective depletion of Hsp90 binding signaling molecules.
KIAA1324 Suppresses Gastric Cancer Progression by Inhibiting the Oncoprotein GRP78.
Kidney injury and alterations of inflammatory cytokine expressions in mice following long-term exposure to cerium chloride.
Kill and spread the word: stimulation of antitumor immune responses in the context of radiotherapy.
Killing of normal melanocytes, combined with heat shock protein 70 and CD40L expression, cures large established melanomas.
Kinetic and structural characterization of human mortalin.
Knockdown of glucose-regulated protein 78 abrogates chemoresistance of hypopharyngeal carcinoma cells to cisplatin induced by unfolded protein in response to severe hypoxia.
Knockdown of lncRNA ZNRD1-AS1 suppresses gastric cancer cell proliferation and metastasis by targeting the miR-9-5p/HSP90AA1 axis.
Knockdown of microRNA-29a Changes the Expression of Heat Shock Proteins in Breast Carcinoma MCF-7 Cells.
Korean ginseng extract ameliorates abnormal immune response through the regulation of inflammatory constituents in Sprague Dawley rat subjected to environmental heat stress.
KU135, a Novel Novobiocin-derived C-terminal Inhibitor of Hsp90, Exerts Potent Antiproliferative Effects in Human Leukemic Cells.
KU675, a Concomitant Heat-Shock Protein Inhibitor of Hsp90 and Hsc70 that Manifests Isoform Selectivity for Hsp90? in Prostate Cancer Cells.
Label-free LC-MSe in tissue and serum reveals protein networks underlying differences between benign and malignant serous ovarian tumors.
Lactobacilli Modulate Hypoxia-Inducible Factor (HIF)-1 Regulatory Pathway in Triple Negative Breast Cancer Cell Line.
Landscape of the mitochondrial Hsp90 metabolome in tumours.
Lapatinib resistance in HER2+ cancers: latest findings and new concepts on molecular mechanisms.
Lead generation of heat shock protein 90 inhibitors by a combination of fragment-based approach, virtual screening, and structure-based drug design.
Lead identification of ?-lactam and related imine inhibitors of the molecular chaperone heat shock protein 90.
Lectin, galactoside-binding soluble 3 binding protein promotes 17-N-Allylamino-17-demethoxygeldanamycin resistance through PI3K/Akt pathway in lung cancer cell line.
Lectin-like oxidized low-density lipoprotein receptor-1 delivers heat shock protein 60-fused antigen into the MHC class I presentation pathway.
Lens epithelium-derived growth factor is an Hsp70-2 regulated guardian of lysosomal stability in human cancer.
Leptin as a mediator of tumor-stromal interactions promotes breast cancer stem cell activity.
Leptin improves the in vitro development of preimplantation rabbit embryos under oxidative stress of cryopreservation.
Lessons from Cancer: Subcellular Drug Targeting of Mitochondrial Hsp90 in Pulmonary Arterial Hypertension.
Leveraging ectopic Hsp90 expression to assay the presence of tumor cells and aggressive tumor phenotypes in breast specimens.
Ligand Binding, Unbinding and Allosteric Effects: Deciphering Small-Molecule Modulation of HSP90.
Ligand-targeted theranostic nanomedicines against cancer.
Ligation of cancer cell surface GRP78 with antibodies directed against its COOH-terminal domain up-regulates p53 activity and promotes apoptosis.
Ligation of cell surface GRP78 with antibody directed against the COOH-terminal domain of GRP78 suppresses Ras/MAPK and PI 3-kinase/AKT signaling while promoting caspase activation in human prostate cancer cells.
Light-activated oxygen self-supplied starving therapy in near-infrared (NIR) window and adjuvant hyperthermia-induced tumor ablation with an augmented sensitivity.
Linking hsp90's role as an evolutionary capacitator to the development of cancer.
Lipopolysaccharide-free heat shock protein 60 activates T cells.
Liposomal delivery of heat shock protein 72 into renal tubular cells blocks nuclear factor-kappaB activation, tumor necrosis factor-alpha production, and subsequent ischemia-induced apoptosis.
Liposomal quercetin efficiently suppresses growth of solid tumors in murine models.
Liver dual arterial blood supply maintains liver regeneration: Analysis of signaling pathways in rats.
Liver metabolic disruption induced after a single exposure to PCB126 in rats.
LncRNA-TP53TG1 Participated in the Stress Response Under Glucose Deprivation in Glioma.
Local radiotherapy increases the level of autoantibodies to ribosomal P0 protein but not to heat shock proteins, extracellular matrix molecules and EGFR/ErbB2 receptors in prostate cancer patients.
Localization and significance of molecular chaperones, heat shock protein 1, and tumor rejection antigen gp96 in the male reproductive tract and during capacitation and acrosome reaction.
Localization of heat shock protein 110 in canine mammary gland tumors.
Long non-coding RNA NKILA regulates expression of HSP90?, NF-?B and ?-catenin proteins in the MCF-7 breast cancer cell line.
Long-term effect of heat shock protein 60 from Actinobacillus actinomycetemcomitans on epithelial cell viability and mitogen-activated protein kinases.
Long-term protection against HPV E7-positive tumor by a single vaccination of AAV vectors encoding a fusion protein of inactivated E7 of HPV 16/18 and heat shock protein 70.
Loss of HDAC6, a novel CHIP substrate, alleviates abnormal tau accumulation.
Low co-expression of epidermal growth factor receptor and its chaperone heat shock protein 90 is associated with worse prognosis in primary glioblastoma, IDH-wild-type.
Low dose geldanamycin inhibits hepatocyte growth factor and hypoxia-stimulated invasion of cancer cells.
Low dose HSP90 inhibition with AUY922 blunts rapid evolution of metastatic and drug resistant phenotypes induced by TGF-? and paclitaxel in A549 cells.
Low intensity focused ultrasound (LOFU) modulates unfolded protein response and sensitizes prostate cancer to 17AAG.
Low-Dose Hsp90 Inhibitor Selectively Radiosensitizes HNSCC and Pancreatic Xenografts.
Low-dose Hsp90 inhibitors tumor-selectively sensitize bladder cancer cells to chemoradiotherapy.
LOXL1?AS1 promotes thymoma and thymic carcinoma progression by regulating miR?525?5p?HSPA9.
LPS induces pp60c-src-mediated tyrosine phosphorylation of Hsp90 in lung vascular endothelial cells and mouse lung.
Lymph node metastasis could be predicted by evaluation of macrophage infiltration and hsp70 expression in superficial carcinoma of the esophagus.
Lysosomal Rerouting of Hsp70 Trafficking as a Potential Immune Activating Tool for Targeting Melanoma.
m5C Methylation Guides Systemic Transport of Messenger RNA over Graft Junctions in Plants.
Macrocycles that inhibit the binding between heat shock protein 90 and TPR-containing proteins.
Macrocyclic inhibitors of hsp90.
Macrocyclic lactams as potent Hsp90 inhibitors with excellent tumor exposure and extended biomarker activity.
Macrophage Inflammatory Protein Derivative ECI301 Enhances the Alarmin-Associated Abscopal Benefits of Tumor Radiotherapy.
Macrophages orchestrate the immune response to tumor cell death.
Magnetic nanoparticle-mediated hyperthermia therapy induces tumour growth inhibition by apoptosis and Hsp90/AKT modulation.
Magnetic resonance spectroscopic pharmacodynamic markers of the heat shock protein 90 inhibitor 17-allylamino,17-demethoxygeldanamycin (17AAG) in human colon cancer models.
Magnetic thermoablation stimuli alter BCL2 and FGF-R1 but not HSP70 expression profiles in BT474 breast tumors.
Major heat shock protein hsp70 protects tumor cells from tumor necrosis factor cytotoxicity.
Making HSP90 Inhibitors Great Again? Unite for Better Cancer Immunotherapy.
Mapping of the genes for human endoplasmic reticular heat shock protein gp96/grp94.
Marchantin M Induces Apoptosis of Prostate Cancer Cells Through Endoplasmic Reticulum Stress.
Marked induction of HSP47, a collagen-binding stress protein, during solid tumor formation of ascitic Sarcoma 180 in vivo.
Massage therapy attenuates inflammatory signaling after exercise-induced muscle damage.
Mathematical modelling of the influence of heat shock proteins on cancer invasion of tissue.
Maximizing the Therapeutic Potential of Hsp90 Inhibitors.
MDM2 chaperones the p53 tumor suppressor.
Measurement and mathematical modeling of thermally induced injury and heat shock protein expression kinetics in normal and cancerous prostate cells.
Measurement and modification of the expression level of the chaperone protein and signaling regulator GRP78/BiP in mammalian cells.
Measuring the pharmacodynamic effects of a novel Hsp90 inhibitor on HER2/neu expression in mice using Zr-DFO-trastuzumab.
Mechanism study of peptide GMBP1 and its receptor GRP78 in modulating gastric cancer MDR by iTRAQ-based proteomic analysis.
Mechanism underlying berberine's effects on HSP70/TNF? under heat stress: Correlation with the TATA boxes.
Mechanism underlying the development of myeloproliferative neoplasms through mutant calreticulin.
Mechanisms of apoptosis by the tumor suppressor Par-4.
Mechanisms of decreased Vitamin D 1alpha-hydroxylase activity in prostate cancer cells.
Mechanisms of disease: the role of heat-shock protein 90 in genitourinary malignancy.
Mechanisms of endogenous MHC class II presentation by tumor cells.
Mechanisms of Resistance to Hsp90 Inhibitor Drugs: A Complex Mosaic Emerges.
Mechanisms of Thrombocytopenia During Septic Shock: A Multiplex Cluster Analysis of Endogenous Sepsis Mediators.
Mechanistic Asymmetry in Hsp90 Dimers.
Mechanistic evaluation of the novel HSP90 inhibitor NVP-AUY922 in adult and pediatric glioblastoma.
Mechanistic studies of a peptidic GRP78 ligand for cancer cell-specific drug delivery.
Mechanistic studies of Sansalvamide A-amide: an allosteric modulator of Hsp90.
Mechanistic studies on Hsp90 inhibition by ansamycin derivatives.
Medical Gas Plasma Jet Technology Targets Murine Melanoma in an Immunogenic Fashion.
Medium tumor antigen of polyomavirus transformation-defective mutant NG59 is associated with 73-kilodalton heat shock protein.
Medium-Chain Triglycerides Attenuate Liver Injury in Lipopolysaccharide-Challenged Pigs by Inhibiting Necroptotic and Inflammatory Signaling Pathways.
Medium-Throughput Detection of Hsp90/Cdc37 Protein-Protein Interaction Inhibitors Using a Split Renilla Luciferase-Based Assay.
Megakaryocytes mediate hyperglycemia-induced tumor metastasis.
Melanoma and the Unfolded Protein Response.
Melanoma-targeted chemo-thermo-immuno (CTI)-therapy using N-propionyl-4-S-cysteaminylphenol-magnetite nanoparticles elicits CTL response via heat shock protein-peptide complex release.
Members of the heat-shock protein 70 family promote cancer cell growth by distinct mechanisms.
Membrane heat shock protein 70: a theranostic target for cancer therapy.
Membrane Hsp70-supported cell-to-cell connections via tunneling nanotubes revealed by live-cell STED nanoscopy.
Membrane phospholipids, EML4-ALK, and Hsp90 as novel targets in lung cancer treatment.
Membrane-anchored heat-shock protein 70 (Hsp70) in cancer.
Membrane-bound heat shock protein 70 (Hsp70) in acute myeloid leukemia: a tumor specific recognition structure for the cytolytic activity of autologous NK cells.
Membrane-bound HSP70-engineered myeloma cell-derived exosomes stimulate more efficient CD8(+) CTL- and NK-mediated antitumor immunity than exosomes released from heat-shocked tumor cells expressing cytoplasmic HSP70.
Message in a bottle: role of the 70-kDa heat shock protein family in anti-tumor immunity.
Metabolic markers and HSP60 in chemonaive serous solid ovarian cancer versus ascites.
Metabolic stress regulates cytoskeletal dynamics and metastasis of cancer cells.
Metabolite elucidation of the Hsp90 inhibitor SNX-2112 using ultraperformance liquid chromatography/quadrupole time-of-flight mass spectrometry (UPLC-QTOF/MS).
Metastasis and the Tumor Microenvironment: A Joint Metastasis Research Society-AACR Conference - Research on Metastasis: Part 2.
Methionine to isothreonine conversion as a source of false discovery identifications of genetically encoded variants in proteogenomics.
Methods to validate Hsp90 inhibitor specificity, to identify off-target effects, and to rethink approaches for further clinical development.
Methylglyoxal and Small Heat Shock Proteins.
Methylglyoxal, a glycolysis side-product, induces Hsp90 glycation and YAP-mediated tumor growth and metastasis.
MHC-class-I expression in human breast cancer correlates with nuclear localization of the 90 kDa heat-shock-protein.
Microglial activation and amyloid-beta clearance induced by exogenous heat-shock proteins.
MicroRNA overexpression increases cortical neuronal vulnerability to injury.
MicroRNA-361-Mediated Inhibition of HSP90 Expression and EMT in Cervical Cancer Is Counteracted by Oncogenic lncRNA NEAT1.
MicroRNA-495-3p inhibits multidrug resistance by modulating autophagy through GRP78/mTOR axis in gastric cancer.
MicroRNA216b mediated downregulation of HSP27/STAT3/AKT signaling is critically involved in lambertianic acid induced apoptosis in human cervical cancers.
MicroRNAs and Heat Shock Proteins in Breast Cancer Biology.
Microwave-assisted one step synthesis of 8-arylmethyl-9H-purin-6-amines.
Milan PM1 Induces Adverse Effects on Mice Lungs and Cardiovascular System.
Mild hyperthermia inhibits homologous recombination, induces BRCA2 degradation, and sensitizes cancer cells to poly (ADP-ribose) polymerase-1 inhibition.
Mild hypothermia facilitates the expression of cold-inducible RNA-binding protein and heat shock protein 70.1 in mouse brain.
Mild Magnetic Hyperthermia-Activated Innate Immunity for Liver Cancer Therapy.
Mimetic Heat Shock Protein Mediated Immune Process to Enhance Cancer Immunotherapy.
Mimetic sHDL nanoparticles: A novel drug-delivery strategy to target triple-negative breast cancer.
MiR-181a Inhibits Cervical Cancer Development Via Downregulating GRP78.
miR-199a-5p and miR-495 target GRP78 within UPR pathway of lung cancer.
miR-30d, miR-181a and miR-199a-5p cooperatively suppress the endoplasmic reticulum chaperone and signaling regulator GRP78 in cancer.
miR-485-5p/HSP90 axis blocks Akt1 phosphorylation to suppress osteosarcoma cell proliferation and migration via PI3K/AKT pathway.
miR-541-3p enhances the radiosensitivity of prostate cancer cells by inhibiting HSP27 expression and downregulating ?-catenin.
miR?495 enhances the efficacy of radiotherapy by targeting GRP78 to regulate EMT in nasopharyngeal carcinoma cells.
miRNA mediated up-regulation of cochaperone p23 acts as an anti-apoptotic factor in childhood acute lymphoblastic leukemia.
Mitochondria chaperone GRP75 moonlighting as a cell cycle controller to derail endocytosis provides an opportunity for nanomicrosphere intracellular delivery.
Mitochondria-targeting NO gas nanogenerator for augmenting mild photothermal therapy in the NIR-II biowindow.
Mitochondrial chaperone tumour necrosis factor receptor-associated protein 1 protects cardiomyocytes from hypoxic injury by regulating mitochondrial permeability transition pore opening.
Mitochondrial chaperone, TRAP1 as a potential pharmacological target to combat cancer metabolism.
Mitochondrial chaperone, TRAP1 modulates mitochondrial dynamics and promotes tumor metastasis.
Mitochondrial chaperones in cancer: from molecular biology to clinical diagnostics.
Mitochondrial Chaperonin HSP60 Is the Apoptosis-Related Target for Myrtucommulone.
Mitochondrial heat shock protein mortalin as potential target for therapies based on oxidative stress.
Mitochondrial Heat Shock Protein-90 Modulates Vascular Smooth Muscle Cell Survival and the Vascular Injury Response in Vivo.
Mitochondrial heat shock protein-guided photodynamic therapy.
Mitochondrial HSP90 Accumulation Promotes Vascular Remodeling in Pulmonary Arterial Hypertension.
Mitochondrial HSP90s and tumor cell metabolism.
Mitochondrial matrix chaperone and c-myc inhibition causes enhanced lethality in glioblastoma.
Mitochondrial oxidative phosphorylation TRAP(1)ped in tumor cells.
Mitochondrial-targeted Hsp90 C-terminal inhibitors manifest anti-proliferative activity.
Mitofusin-2 regulates inflammation-mediated mouse neuroblastoma N2a cells dysfunction and endoplasmic reticulum stress via the Yap-Hippo pathway.
Mitogen-activated protein kinase kinase 4 (MAP2K4) promotes human prostate cancer metastasis.
Mitogen-activated protein kinase-activated protein kinase 2 in neuroinflammation, heat shock protein 27 phosphorylation, and cell cycle: role and targeting.
Mode of cell death induced by the HSP90 inhibitor 17-AAG (tanespimycin) is dependent on the expression of pro-apoptotic BAX.
Modeling and docking studies on novel mutants (K71L and T204V) of the ATPase domain of human heat shock 70 kDa protein 1.
Modeling signal propagation mechanisms and ligand-based conformational dynamics of the Hsp90 molecular chaperone full-length dimer.
Modified biphenyl Hsp90 C-terminal inhibitors for the treatment of cancer.
Modulating Heat Shock Proteins 70 and 90 Expression by Low Power Laser Irradiation (635nm and 780nm) in Jurkat E6.1 T-lymphocyte Leukemia Cell Line.
Modulation of Hsp90 function by ansamycins sensitizes breast cancer cells to chemotherapy-induced apoptosis in an RB- and schedule-dependent manner. See: E. A. Sausville, Combining cytotoxics and 17-allylamino, 17-demethoxygeldanamycin: sequence and tumor biology matters, Clin. Cancer Res., 7: 2155-2158, 2001.
Modulation of Human Hsp90? Conformational Dynamics by Allosteric Ligand Interaction at the C-Terminal Domain.
Modulation of melanoma cell phospholipid metabolism in response to heat shock protein 90 inhibition.
Modulation of Mitochondrial Metabolic Reprogramming and Oxidative Stress to Overcome Chemoresistance in Cancer.
Modulation of p53, ErbB1, ErbB2, and Raf-1 expression in lung cancer cells by depsipeptide FR901228.
Modulation of the unfolded protein response by GRP78 in prostate cancer.
Modulation of the unfolded protein response in prostate cancer cells by antibody-directed against the carboxyl-terminal domain of GRP78.
Modulatory effects of curcumin on heat shock proteins in cancer: A promising therapeutic approach.
Modulatory effects of mycobacterial heat-shock protein 70 in DNA vaccination against lymphoma.
Molecular aberrations in the MHC class I-restricted pathway for antigen presentation in methylcholanthrene sarcomas from nude mice: discrepancies between MHC mRNA and surface protein.
Molecular and cellular basis for the anti-proliferative effects of the HDAC inhibitor LAQ824.
Molecular and cellular requirements for enhanced antigen cross-presentation to CD8 cytotoxic T lymphocytes.
Molecular and Clinical Characterization of CCT2 Expression and Prognosis via Large-Scale Transcriptome Profile of Breast Cancer.
Molecular and functional crosstalk between extracellular Hsp90 and ephrin A1 signaling.
Molecular basis for the actions of Hsp90 inhibitors and cancer therapy.
Molecular Chaperone Accumulation in Cancer and Decrease in Alzheimer's Disease: The Potential Roles of HSF1.
Molecular chaperone complexes with antagonizing activities regulate stability and activity of the tumor suppressor LKB1.
Molecular Chaperone GRP94/GP96 in Cancers: Oncogenesis and Therapeutic Target.
Molecular chaperone Hsp27 regulates the Hippo tumor suppressor pathway in cancer.
Molecular chaperone Hsp90 as a target for oxidant-based anticancer therapies.
Molecular chaperone Hsp90 is a therapeutic target for noroviruses.
Molecular Chaperone HSP90 Is Necessary to Prevent Cellular Senescence via Lysosomal Degradation of p14ARF.
Molecular chaperone therapy- the future in cancer.
Molecular chaperone TRAP1 regulates a metabolic switch between mitochondrial respiration and aerobic glycolysis.
Molecular Chaperones and Thyroid Cancer.
Molecular chaperones as regulators of cell death.
Molecular Chaperones in Cancer Stem Cells: Determinants of Stemness and Potential Targets for Antitumor Therapy.
Molecular chaperones stimulate bone resorption.
Molecular characterization of hsp90 isoforms in colorectal cancer cells and its association with tumour progression.
Molecular characterization of macbecin as an Hsp90 inhibitor.
Molecular cochaperones: tumor growth and cancer treatment.
Molecular design of anticancer drug leads based on three-dimensional quantitative structure-activity relationship.
Molecular docking and molecular dynamics studies reveal structural basis of inhibition and selectivity of inhibitors EGCG and OSU-03012 toward glucose regulated protein-78 (GRP78) overexpressed in glioblastoma.
Molecular docking and pharmacophore studies of heterocyclic compounds as Heat shock protein 90 (Hsp90) Inhibitors.
Molecular docking simulation analysis of the interaction of dietary flavonols with heat shock protein 90.
Molecular docking study, synthesis and biological evaluation of Schiff bases as Hsp90 inhibitors.
Molecular imaging of the efficacy of heat shock protein 90 inhibitors in living subjects.
Molecular markers for novel therapies in neuroendocrine (carcinoid) tumors.
Molecular mechanism of cytotoxicity induced by Hsp90-targeted Antp-TPR hybrid peptide in glioblastoma cells.
Molecular mechanism of kidney injury of mice caused by exposure to titanium dioxide nanoparticles.
Molecular mechanisms of anti-tumor properties of P276-00 in head and neck squamous cell carcinoma.
Molecular Pathways: GLI1-Induced Drug Glucuronidation in Resistant Cancer Cells.
Molecular pathways: targeting hsp90--who benefits and who does not.
Molecular sequelae of proteasome inhibition in human multiple myeloma cells.
Molecular signature of response and potential pathways related to resistance to the HSP90 inhibitor, 17AAG, in breast cancer.
Molecular Targeting-Mediated Mild-Temperature Photothermal Therapy with a Smart Albumin-Based Nanodrug.
Molecular Targets Implicated in the Antiparasitic and Anti-Inflammatory Activity of the Phytochemical Curcumin in Trichomoniasis.
Molecular-biological analysis of acute lung injury (ALI) induced by heat exposure and/or intravenous administration of oleic acid.
Molecularly engineered carrier-free co-delivery nanoassembly for self-sensitized photothermal cancer therapy.
Molecularly targeted therapies in multiple myeloma.
Monitoring HSP70 exosomes in cancer patients' follow up: a clinical prospective pilot study.
Monitoring of Heat Shock Response and Phenotypic Changes in Hepatocellular Carcinoma After Heat Treatment.
Monitoring therapeutic response of human ovarian cancer to 17-DMAG by noninvasive PET imaging with (64)Cu-DOTA-trastuzumab.
Monoclonal antibody 4C5 immunostains human melanomas and inhibits melanoma cell invasion and metastasis.
Monoclonal antibody 4C5 prevents activation of MMP2 and MMP9 by disrupting their interaction with extracellular HSP90 and inhibits formation of metastatic breast cancer cell deposits.
Monoclonal Antibody against Cell Surface GRP78 as a Novel Agent in Suppressing PI3K/AKT Signaling, Tumor Growth and Metastasis.
Monoclonal antibody to novel cell surface epitope on Hsc70 promotes morphogenesis of bile ducts in newborn rat liver.
More efficient induction of HLA-A*0201-restricted and carcinoembryonic antigen (CEA)-specific CTL response by immunization with exosomes prepared from heat-stressed CEA-positive tumor cells.
Mortalin (GRP75/HSPA9) Promotes Survival and Proliferation of Thyroid Carcinoma Cells.
Mortalin (HSPA9) facilitates BRAF-mutant tumor cell survival by suppressing ANT3-mediated mitochondrial membrane permeability.
Mortalin antibody-conjugated quantum dot transfer from human mesenchymal stromal cells to breast cancer cells requires cell-cell interaction.
Mortalin depletion induces MEK/ERK-dependent and ANT/CypD-mediated death in vemurafenib-resistant B-RafV600E melanoma cells.
Mortalin expression in pancreatic cancer and its clinical and prognostic significance.
Mortalin imaging in normal and cancer cells with quantum dot immuno-conjugates.
Mortalin inhibitors sensitize K562 leukemia cells to complement-dependent cytotoxicity.
Mortalin is a distinct bio-marker and prognostic factor in serous ovarian carcinoma.
Mortalin is over-expressed by colorectal adenocarcinomas and correlates with poor survival.
Mortalin maintains breast cancer stem cells stemness via activation of Wnt/GSK3?/?-catenin signaling pathway.
Mortalin peptides exert antitumor activities and act as adjuvants to antibody-mediated complement-dependent cytotoxicity.
Mortalin promotes breast cancer malignancy.
Mortalin promotes cell proliferation and epithelial mesenchymal transition of intrahepatic cholangiocarcinoma cells in vitro.
Mortalin sensitizes human cancer cells to MKT-077-induced senescence.
Mortalin stabilizes CD151-depedent tetraspanin-enriched microdomains and implicates in the progression of hepatocellular carcinoma.
Mortalin, apoptosis, and neurodegeneration.
Mortalin-based cytoplasmic sequestration of p53 in a nonmammalian cancer model.
Mortalin-p53 interaction in cancer cells is stress dependent and constitutes a selective target for cancer therapy.
Mortalin/HSPA9 targeting selectively induces KRAS tumor cell death by perturbing mitochondrial membrane permeability.
Mortalin - a multipotent chaperone regulating cellular processes ranging from viral infection to neurodegeneration.
Mortaparib, a novel dual inhibitor of mortalin and PARP1, is a potential drug candidate for ovarian and cervical cancers.
Mps1 Mediated Phosphorylation of Hsp90 Confers Renal Cell Carcinoma Sensitivity and Selectivity to Hsp90 Inhibitors.
MT-4 suppresses resistant ovarian cancer growth through targeting tubulin and HSP27.
mTOR Inhibition Potentiates HSP90 Inhibitor Activity via Cessation of Heat Shock Protein Synthesis.
Multi-faceted proteomic characterization of host protein complement of Rift Valley fever virus virions and identification of specific heat shock proteins, including HSP90, as important viral host factors.
Multi-faceted role of HSP40 in cancer.
Multi-level ecotoxicological effects of imidacloprid on earthworm (Eisenia fetida).
Multi-panel assay of serum autoantibodies in colorectal cancer.
Multicenter Phase II Trial of the Heat Shock Protein 90 Inhibitor, Retaspimycin Hydrochloride (IPI-504), in Patients With Castration-resistant Prostate Cancer.
Multiclass comparative virtual screening to identify novel Hsp90 inhibitors: a therapeutic breast cancer drug target.
Multidimensional degradomics identifies systemic autoantigens and intracellular matrix proteins as novel gelatinase B/MMP-9 substrates.
Multifaceted intervention by the Hsp90 inhibitor ganetespib (STA-9090) in cancer cells with activated JAK/STAT signaling.
Multifocal angiostatic therapy: an update.
Multifunctional low-temperature photothermal nanodrug with in vivo clearance, ROS-Scavenging and anti-inflammatory abilities.
Multifunctional Magnetic Nanoplatform Eliminates Cancer Stem Cells via Inhibiting the Secretion of Extracellular Heat Shock Protein 90.
Multifunctional selenium nanoparticles as carriers of HSP70 siRNA to induce apoptosis of HepG2 cells.
Multifunctional TPP-PEG-biotin self-assembled nanoparticle drug delivery-based combination therapeutic approach for co-targeting of GRP78 and lysosome.
Multiple Kinase Pathways Involved in the Different De Novo Sensitivity of Pancreatic Cancer Cell Lines to 17-AAG.
Multiple p53 protein isoforms and formation of oligomeric complexes with heat shock proteins Hsp70 and Hsp90 in the human mammary tumor, T47D, cell line.
Multiplex Cytokine Profiling Identifies Interleukin-27 as a Novel Biomarker for Neonatal Early Onset Sepsis.
Multiplex H. pylori serology and risk of gastric cardia and non-cardia adenocarcinomas.
Muscadine grape skin extract inhibits prostate cancer cells by inducing cell-cycle arrest, and decreasing migration through heat shock protein 40.
Muscle Antioxidant Activity and Meat Quality Are Altered by Supplementation of Astaxanthin in Broilers Exposed to High Temperature.
Muscle endurance in elderly nursing home residents is related to fatigue perception, mobility, and circulating tumor necrosis factor-alpha, interleukin-6, and heat shock protein 70.
Mutation of the co-chaperone Tsc1 in bladder cancer diminishes Hsp90 acetylation and reduces drug sensitivity and selectivity.
Mutations Y493G and K546D in human HSP90 disrupt binding of celastrol and reduce interaction with Cdc37.
Myc-mediated transcriptional regulation of the mitochondrial chaperone TRAP1 controls primary and metastatic tumor growth.
Mycobacterial 65-kilodalton heat shock protein induces tumor necrosis factor alpha and interleukin 6, reactive nitrogen intermediates, and toxoplasmastatic activity in murine peritoneal macrophages.
N,N'-dinitrosopiperazine--mediated heat-shock protein 70-2 expression is involved in metastasis of nasopharyngeal carcinoma.
N-alkyl-hydroxybenzoyl anilide hydroxamates as dual inhibitors of HDAC and HSP90, downregulating IFN-? induced PD-L1 expression.
N-Formyl-3,4-methylenedioxy-benzylidene-gamma-butyrolaetam, KNK437 induces caspase-3 activation through inhibition of mTORC1 activity in Cos-1 cells.
N-terminal and C-terminal modulation of Hsp90 produce dissimilar phenotypes.
NaCN-induced chemical hypoxia is associated with altered gene expression.
NAD(P)H:quinone oxidoreductase 1 (NQO1) in the sensitivity and resistance to antitumor quinones.
Nanobubble Ultrasound Contrast Agents for Enhanced Delivery of Thermal Sensitizer to Tumors Undergoing Radiofrequency Ablation.
Nanoengineered Disruption of Heat Shock Protein 90 Targets Drug-Induced Resistance and Relieves Natural Killer Cell Suppression in Breast Cancer.
Nanofitins targeting heat shock protein 110: An innovative immunotherapeutic modality in cancer.
Nanoparticles inhibit cancer cell invasion and enhance antitumor efficiency by targeted drug delivery via cell surface-related GRP78.
Natural and semisynthetic azaphilones as a new scaffold for Hsp90 inhibitors.
Natural compounds as potential Hsp90 inhibitors for breast cancer-Pharmacophore guided molecular modelling studies.
Natural heat shock protein 90 inhibitors in cancer and inflammation.
Natural iminosugar (+)-lentiginosine inhibits ATPase and chaperone activity of hsp90.
Natural Infection with Rabies Virus: A Histopathological and Immunohistochemical Study of Human Brains.
Natural killer cells play a key role in the antitumor immunity generated by chaperone-rich cell lysate vaccination.
Natural product inhibitors of Hsp90: potential leads for drug discovery.
Natural Product Inspired N-Terminal Hsp90 Inhibitors: From Bench to Bedside?
Natural Product Kongensin A is a Non-Canonical HSP90 Inhibitor that Blocks RIP3-dependent Necroptosis.
Natural Products in Structure-Assisted Design of Molecular Cancer Therapeutics.
Natural Withanolides in the Treatment of Chronic Diseases.
NECA derivatives exploit the paralog-specific properties of the Site 3 side pocket of Grp94, the ER Hsp90.
Neoadjuvant and adjuvant strategies in renal cell carcinoma: more questions than answers.
Nephro-toxic effects of intraperitoneally injected EGCG in diabetic mice: involvement of oxidative stress, inflammation and apoptosis.
Network pharmacology-based and clinically relevant prediction of the active ingredients and potential targets of Chinese herbs in metastatic breast cancer patients.
Neutral analogs of the heat shock protein 70 (Hsp70) inhibitor, JG-98.
New aspects of the hormone and cytokine response to training.
New developments in Hsp90 inhibitors as anti-cancer therapeutics: mechanisms, clinical perspective and more potential.
New geldanamycin analogs from Streptomyces hygroscopicus.
New heat shock protein (Hsp90) inhibitors, designed by pharmacophore modeling and virtual Screening: Synthesis, Biological evaluation and molecular dynamics studies.
New insights into molecular chaperone TRAP1 as a feasible target for future cancer treatments.
New insights into TRAP1 pathway.
New modification strategy of matrine as Hsp90 inhibitors based on its specific L conformation for cancer treatment.
New role of endoplasmic reticulum chaperones in regulating metaplasia during tumorigenesis.
Nickel and Oxidative stress: Cell Signaling Mechanisms and Protective Role of Vitamin C.
NIR-activated self-sensitized polymeric micelles for enhanced cancer chemo-photothermal therapy.
NIR-controlled HSP90 inhibitor release from hollow mesoporous nanocarbon for synergistic tumor photothermal therapy guided by photoacoustic imaging.
NIR-II Absorbing Semiconducting Polymer-Triggered Gene-Directed Enzyme Prodrug Therapy for Cancer Treatment.
NIR-II Excitation Phototheranostic Nanomedicine for Fluorescence/Photoacoustic Tumor Imaging and Targeted Photothermal-Photonic Thermodynamic Therapy.
Nitration of Hsp90 on Tyrosine 33 Regulates Mitochondrial Metabolism.
Nitric oxide protects cultured rat hepatocytes from tumor necrosis factor-alpha-induced apoptosis by inducing heat shock protein 70 expression.
NKX3.1 Localization to Mitochondria Suppresses Prostate Cancer Initiation.
NMS-E973, a novel synthetic inhibitor of Hsp90 with activity against multiple models of drug resistance to targeted agents, including intracranial metastases.
Non-Benzoquinone Geldanamycin Analog, WK-88-1, Induces Apoptosis in Human Breast Cancer Cell Lines.
Non-HLA gene polymorphisms and the outcome of allogeneic hemato-poietic stem cell transplantation.
Non-invasive MRI tumor imaging and synergistic anticancer effect of HSP90 inhibitor and glycolysis inhibitor in RIP1-Tag2 transgenic pancreatic tumor model.
Non-invasive PET imaging of EGFR degradation induced by a heat shock protein 90 inhibitor.
Non-specific chemical inhibition of the Fanconi anemia pathway sensitizes cancer cells to cisplatin.
Noncovalent association with stress protein facilitates cross-priming of CD8+ T cells to tumor cell antigens by dendritic cells.
Nonsteroidal Anti-inflammatory Drugs Sensitize CD44-Overexpressing Cancer Cells to Hsp90 Inhibitor Through Autophagy Activation.
Nonviral nanoscale-based delivery of antisense oligonucleotides targeted to hypoxia-inducible factor 1 alpha enhances the efficacy of chemotherapy in drug-resistant tumor.
Novel 1,6-naphthyridin-2(1H)-ones as potential anticancer agents targeting Hsp90.
Novel adjuvant dendritic cell therapy with transfection of heat-shock protein 70 messenger RNA for patients with hepatocellular carcinoma: a phase I/II prospective randomized controlled clinical trial.
Novel antitumor and neuroprotective substances discovered by characteristic screenings based on specific molecular targets.
Novel C-Terminal Heat Shock Protein 90 Inhibitors (KU711 and Ku757) Are Effective in Targeting Head and Neck Squamous Cell Carcinoma Cancer Stem cells.
Novel C-Terminal Hsp90 Inhibitor for Head and Neck Squamous Cell Cancer (HNSCC) with in vivo Efficacy and Improved Toxicity Profiles Compared with Standard Agents.
Novel findings in gene expression detected in human osteosarcoma by cDNA microarray.
Novel Heat Shock Protein 90 Inhibitors Suppress P-Glycoprotein Activity and Overcome Multidrug Resistance in Cancer Cells.
Novel Hsp90 Inhibitor C086 Potently Inhibits Non-Small Cell Lung Cancer Cells As A Single Agent Or In Combination With Gefitinib.
Novel Hsp90 inhibitor FW-04-806 displays potent antitumor effects in HER2-positive breast cancer cells as a single agent or in combination with lapatinib.
Novel Hsp90 inhibitor NVP-AUY922 radiosensitizes prostate cancer cells.
Novel HSP90 inhibitor NVP-HSP990 targets cell cycle regulators to ablate Olig2-positive glioma tumor initiating cells.
Novel Hsp90 inhibitor platycodin D disrupts Hsp90/Cdc37 complex and enhances the anticancer effect of mTOR inhibitor.
Novel HSP90 inhibitors, NVP-AUY922 and NVP-BEP800, radiosensitise tumour cells through cell-cycle impairment, increased DNA damage and repair protraction.
Novel mechanism of apoptosis resistance in cancer mediated by extracellular PAR-4.
Novel Miniaturized Drug Conjugate Leverages HSP90-driven Tumor Accumulation to Overcome PI3K Inhibitor Delivery Challenges to Solid Tumors.
Novel molecular mechanism of cellular transformation by a mutant molecular chaperone in myeloproliferative neoplasms.
Novel nontoxic heat shock protein 90 inhibitors having selective antiproliferative effect.
Novel ovarian cancer maintenance therapy targeted at mortalin and mutant p53.
Novel prediction of anticancer drug chemosensitivity in cancer cell lines: evidence of moderation by microRNA expressions.
Novel PRMT5-mediated arginine methylations of HSP90A are essential for maintenance of HSP90A function in NDRG2low ATL and various cancer cells.
Novel roles of holocarboxylase synthetase in gene regulation and intermediary metabolism.
Novel ruthenium(II) triazine complex [Ru(bdpta)(tpy)]2+ co-targeting drug resistant GRP78 and subcellular organelles in cancer stem cells.
Novel serum markers HSP60, CHI3L1, and IGFBP-2 in metastatic colorectal cancer.
Novel Small Molecule Hsp90/Cdc37 Interface Inhibitors Indirectly Target K-Ras-Signaling.
Novel targeted nuclear imaging agent for gastric cancer diagnosis: glucose-regulated protein 78 binding peptide-guided 111In-labeled polymeric micelles.
Novel therapeutic strategies in multiple myeloma: role of the heat shock protein inhibitors.
Novel therapeutic targets for multiple myeloma.
Novel treatment strategies for soft tissue sarcoma.
Novel triazole ribonucleoside down-regulates heat shock protein 27 and induces potent anticancer activity on drug-resistant pancreatic cancer.
Novobiocin analogs as potencial anticancer agents.
Novobiocin analogues with second-generation noviose surrogates.
Novobiocin and additional inhibitors of the Hsp90 C-terminal nucleotide-binding pocket.
Nuclear Accumulation of Heat-shock Protein 90 Is Associated with Poor Survival and Metastasis in Patients with Non-small Cell Lung Cancer.
Nuclear export of proteins and drug resistance in cancer.
Nuclear matrix protein, prohibitin, was down-regulated and translocated from nucleus to cytoplasm during the differentiation of osteosarcoma MG-63 cells induced by ginsenoside Rg1, cinnamic acid, and tanshinone IIA (RCT).
Nucleoporin TPR (translocated promoter region, nuclear basket protein) upregulation alters MTOR-HSF1 trails and suppresses autophagy induction in ependymoma.
Nucleoside-Lipid-Based Nanoparticles for Phenazine Delivery: A New Therapeutic Strategy to Disrupt Hsp27-eIF4E Interaction in Castration Resistant Prostate Cancer.
NVP-AUY922: a novel heat shock protein 90 inhibitor active against xenograft tumor growth, angiogenesis, and metastasis.
NZ28-induced inhibition of HSF1, SP1 and NF-?B triggers the loss of the natural killer cell-activating ligands MICA/B on human tumor cells.
Ochratoxin A upregulates biomarkers associated with hypoxia and transformation in human kidney cells.
OGX-427 inhibits tumor progression and enhances gemcitabine chemotherapy in pancreatic cancer.
Okicamelliaside targets the N-terminal chaperone pocket of HSP90 disrupts the chaperone protein interaction of HSP90-CDC37 and exerts antitumor activity.
Old and New Approaches to Target the Hsp90 Chaperone.
Oncogenic acidic nuclear phosphoproteins ANP32C/D are novel clients of heat shock protein 90.
Oncogenic extracellular HSP70 disrupts the gap-junctional coupling between capillary cells.
Oncogenic HSP60 regulates mitochondrial oxidative phosphorylation to support Erk1/2 activation during pancreatic cancer cell growth.
Oncogenic HSP90 facilitates metabolic alterations in aggressive B-cell lymphomas.
Oncogenic ras results in increased cell kill due to defective thermoprotection in lung cancer cells.
Oncogenic role of mortalin contributes to ovarian tumorigenesis by activating the MAPK-ERK pathway.
Optical and radioiodinated tethered hsp90 inhibitors reveal selective internalization of ectopic hsp90 in malignant breast tumor cells.
Optical Imaging of Treatment-Related Tumor Cell Death Using a Heat Shock Protein-90 Alkylator.
Optimization and biological evaluation of celastrol derivatives as Hsp90-Cdc37 interaction disruptors with improved druglike properties.
Optimization of expression and purification of human mortalin (Hsp70): Folding/unfolding analysis.
Optimized HSP90 mediated fluorescent probes for cancer-specific bioimaging.
Optimizing heat shock protein expression induced by prostate cancer laser therapy through predictive computational models.
Oral administration of heat-killed Lactobacillus brevis SBC8803 ameliorates alcoholic liver disease in ethanol-containing diet-fed C57BL/6N mice.
Orally active purine-based inhibitors of the heat shock protein 90.
Organoids with cancer stem cell-like properties secrete exosomes and HSP90 in a 3D nanoenvironment.
Oroxin A inhibits breast cancer cell growth by inducing robust endoplasmic reticulum stress and senescence.
Osteoarthritis-related biomarkers profile in chronic anterior cruciate ligament injured knee.
Osteopontin increases breast cancer cell sensitivity to specific signaling pathway inhibitors in preclinical models.
Ovarian Serous Carcinoma With a Novel HSP90AB1 Mutation in a Patient With Synchronous Primary Fallopian Tube Serous Carcinoma.
Over-expression of heat shock protein 70 in mice is associated with growth retardation, tumor formation, and early death.
Over-expression of heat shock proteins in carcinogenic endometrium.
Overcoming acquired resistance to HSP90 inhibition by targeting JAK-STAT signalling in triple-negative breast cancer.
Overcoming drug-tolerant cancer cell subpopulations showing AXL activation and epithelial-mesenchymal transition is critical in conquering ALK-positive lung cancer.
Overcoming HSP27-mediated resistance by altered dimerization of HSP27 using small molecules.
Overcoming immune tolerance to cancer by heat shock protein vaccines.
Overcoming the Heat Endurance of Tumor Cells by Interfering with the Anaerobic Glycolysis Metabolism for Improved Photothermal Therapy.
Overcoming the hypoxia-induced drug resistance in liver tumor by the concurrent use of apigenin and paclitaxel.
Overexpressed GRP78 affects EMT and cell-matrix adhesion via autocrine TGF-?/Smad2/3 signaling.
Overexpression of endoplasmic reticulum molecular chaperone GRP94 and GRP78 in human lung cancer tissues and its significance.
Overexpression of glucose-regulated protein 78 in colon cancer.
Overexpression of GRP78 and GRP94 are markers for aggressive behavior and poor prognosis in gastric carcinomas.
Overexpression of GRP78 and GRP94 is involved in colorectal carcinogenesis.
Overexpression of GRP78 is associated with malignant transformation in epithelial ovarian tumors.
Overexpression of heat shock protein (hsp) 70 associated with abnormal p53 expression in cancer of the pancreas.
Overexpression of heat shock protein 27 (HSP-27) is associated with bad prognosis in oral squamous cell carcinoma.
Overexpression of heat shock protein 27 in squamous cell carcinoma of the uterine cervix: a proteomic analysis using archival formalin-fixed, paraffin-embedded tissues.
Overexpression of HSP10 correlates with HSP60 and Mcl-1 levels and predicts poor prognosis in non-small cell lung cancer patients.
Overexpression of Hsp27 affects the metastatic phenotype of human melanoma cells in vitro.
Overexpression of major heat shock protein hsp70 inhibits tumor necrosis factor-induced activation of phospholipase A2.
Overexpression of molecular chaperons GRP78 and GRP94 in CD44(hi)/CD24(lo) breast cancer stem cells.
Overexpression of Mortalin in hepatocellular carcinoma and its relationship with angiogenesis and epithelial to mesenchymal transition.
Overexpression of PI3K-p110? in the progression of uterine cervical neoplasia and its correlation with pAkt and DJ-1.
Overexpression of ras is an independent prognostic factor in colorectal adenocarcinoma.
Overexpression of ST6GalNAcV, a ganglioside-specific alpha2,6-sialyltransferase, inhibits glioma growth in vivo.
Overexpression of the anti-apoptotic protein BAG3 in human choroidal melanoma: A case report.
Overexpression of the glucose-regulated stress gene GRP78 in malignant but not benign human breast lesions.
Overexpression of the mitochondrial chaperone tumor necrosis factor receptor-associated protein 1 is associated with the poor prognosis of patients with colorectal cancer.
Overexpression of tumor necrosis factor receptor-associated protein 1 (TRAP1), leads to mitochondrial aberrations in mouse fibroblast NIH/3T3 cells.
Overview: translating Hsp90 biology into Hsp90 drugs.
Oxidant stress evoked damage in rat hepatocyte leading to triggered nitric oxide synthase (NOS) levels on long term consumption of aspartame.
Ozone oxidative preconditioning is mediated by A1 adenosine receptors in a rat model of liver ischemia/ reperfusion.
p300 mediates muscle wasting in Lewis lung carcinoma.
P4HB: A novel diagnostic and prognostic biomarker for bladder carcinoma.
p53 expression in brain after middle cerebral artery occlusion in the rat.
p53 independent radio-sensitization of human lymphoblastoid cell lines by Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin.
p53 status-dependent sensitization of human tumour cells to hyperthermia by plant flavonol.
P53-dependent radiosensitizing effects of Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin on human oral squamous cell carcinoma cell lines.
Paclitaxel inhibits expression of heat shock protein 27 in ovarian and uterine cancer cells.
Paclitaxel-doxorubicin sequence is more effective in breast cancer cells with heat shock protein 27 overexpression.
Paeonol protects against testicular ischaemia-reperfusion injury in rats through inhibition of oxidative stress and inflammation.
Pancastatin A and B Have Selective Cytotoxicity on Glucose-Deprived PANC-1 Human Pancreatic Cancer Cells.
Paralog Specificity Determines Subcellular Distribution, Action Mechanism, and Anticancer Activity of TRAP1 Inhibitors.
Paralog-selective Hsp90 inhibitors define tumor-specific regulation of HER2.
Part I of GANNET53: A European Multicenter Phase I/II Trial of the Hsp90 Inhibitor Ganetespib Combined With Weekly Paclitaxel in Women With High-Grade, Platinum-Resistant Epithelial Ovarian Cancer-A Study of the GANNET53 Consortium.
Particulate cytoplasmic structures with high concentration of ubiquitin-proteasome accumulate in myeloid neoplasms.
Past, present, and emerging roles of mitochondrial heat shock protein TRAP1 in the metabolism and regulation of cancer stem cells.
Pathogenicity and virulence of Japanese encephalitis virus: Neuroinflammation and neuronal cell damage.
Pathological Mechanism of Photodynamic Therapy and Photothermal Therapy Based on Nanoparticles.
Patients with colorectal tumors with microsatellite instability and large deletions in HSP110 T17 have improved response to 5-fluorouracil–based chemotherapy.
Patterns of GRP78 and MTJ1 expression in primary cutaneous malignant melanoma.
Penicisulfuranol A, a novel C-terminal inhibitor disrupting molecular chaperone function of Hsp90 independent of ATP binding domain.
Peptide-binding heat shock protein GRP78 protects cardiomyocytes from hypoxia-induced apoptosis.
Peptides and aptamers targeting HSP70: a novel approach for anticancer chemotherapy.
Perfluorooctyl bromide & indocyanine green co-loaded nanoliposomes for enhanced multimodal imaging-guided phototherapy.
Perinecrotic hypoxia contributes to ischemia/reperfusion-accelerated outgrowth of colorectal micrometastases.
Peripheral blood mononuclear cell responses to heat shock proteins in patients undergoing stem cell transplantation.
Peripheral blood mRNA expressions of stress biomarkers in manic episode and subsequent remission.
Peroxiredoxin 1 stimulates secretion of proinflammatory cytokines by binding to TLR4.
Perturbation of HSP Network in MCF-7 Breast Cancer Cell Line Triggers Inducible HSP70 Expression and Leads to Tumor Suppression.
PET imaging of Hsp90 expression in pancreatic cancer using a new 64Cu-labeled dimeric Sansalvamide A decapeptide.
PFT-alpha inhibits antibody-induced activation of p53 and pro-apoptotic signaling in 1-LN prostate cancer cells.
PGK1-coupled HSP90 stabilizes GSK3? expression to regulate the stemness of breast cancer stem cells.
pH-activated heat shock protein inhibition and radical generation enhanced NIR luminescence imaging-guided photothermal tumour ablation.
pH-responsive Ag2S nanodots loaded with heat shock protein 70 inhibitor for photoacoustic imaging-guided photothermal cancer therapy.
Phage display biopanning identifies the translation initiation and elongation factors (IF1?-3 and eIF-3) as components of Hsp70-peptide complexes in breast tumour cells.
Phage display derived human monoclonal antibodies isolated by binding to the surface of live primary breast cancer cells recognize GRP78.
Pharmaceutical Efficacy of Gypenoside LXXV on Non-Alcoholic Steatohepatitis (NASH).
Pharmacogenomics in cancer drug discovery and development: inhibitors of the Hsp90 molecular chaperone.
Pharmacokinetic-pharmacodynamic modeling of biomarker response and tumor growth inhibition to an orally available heat shock protein 90 inhibitor in a human tumor xenograft mouse model.
Pharmacokinetics and pharmacodynamics of 17-demethoxy 17-[[(2-dimethylamino)ethyl]amino]geldanamycin (17DMAG, NSC 707545) in C.B-17 SCID mice bearing MDA-MB-231 human breast cancer xenografts.
Pharmacologic and genetic inhibition of hsp90-dependent trafficking reduces aggregation and promotes degradation of the expanded glutamine androgen receptor without stress protein induction.
Pharmacologic heat shock protein 70 induction confers cytoprotection against inflammation in gliovascular cells.
Pharmacological effectors of GRP78 chaperone in cancers.
Pharmacological induction of cell surface GRP78 contributes to apoptosis in triple negative breast cancer cells.
Pharmacological Inhibition of Hsp90 as a Novel Antitumor Strategy to Target Cytoarchitecture Through Extracellular Matrix Signaling.
Pharmacological Inhibition of HSP90 Radiosensitizes Head and Neck Squamous Cell Carcinoma Xenograft by Inhibition of DNA Damage Repair, Nucleotide Metabolism, and Radiation-Induced Tumor Vasculogenesis.
Pharmacophore-based virtual screening and docking studies on Hsp90 inhibitors.
Pharmacoproteomics study of cetuximab in nasopharyngeal carcinoma.
Phase 1 study of the HSP90 inhibitor onalespib in combination with AT7519, a pan-CDK inhibitor, in patients with advanced solid tumors.
Phase I dose-escalation studies of SNX-5422, an orally bioavailable heat shock protein 90 inhibitor, in patients with refractory solid tumours.
Phase I dose-escalation study of the HSP90 inhibitor AUY922 in Japanese patients with advanced solid tumors.
Phase I evaluation of STA-1474, a prodrug of the novel HSP90 inhibitor ganetespib, in dogs with spontaneous cancer.
Phase I pharmacokinetic and pharmacodynamic study of 17-dimethylaminoethylamino-17-demethoxygeldanamycin, an inhibitor of heat-shock protein 90, in patients with advanced solid tumors.
Phase I Pharmacokinetic and Pharmacodynamic Study of LAQ824, a Hydroxamate Histone Deacetylase Inhibitor with a Heat Shock Protein-90 Inhibitory Profile, in Patients with Advanced Solid Tumors.
Phase I pharmacokinetic-pharmacodynamic study of 17-(allylamino)-17-demethoxygeldanamycin (17AAG, NSC 330507), a novel inhibitor of heat shock protein 90, in patients with refractory advanced cancers.
Phase I Study of BIIB028, a Selective Heat Shock Protein 90 Inhibitor, in Patients with Refractory Metastatic or Locally Advanced Solid Tumors.
Phase I study of KW-2478, a novel Hsp90 inhibitor, in patients with B-cell malignancies.
Phase I study of the heat shock protein 90 (Hsp90) inhibitor onalespib (AT13387) administered on a daily for 2 consecutive days per week dosing schedule in patients with advanced solid tumors.
Phase I study of the heat shock protein 90 inhibitor alvespimycin (KOS-1022, 17-DMAG) administered intravenously twice weekly to patients with acute myeloid leukemia.
Phase I trial of 17-dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG), a heat shock protein inhibitor, administered twice weekly in patients with advanced malignancies.
Phase I trial of the HSP90 inhibitor PF-04929113 (SNX5422) in adult patients with recurrent, refractory hematologic malignancies.
Phase I-II study of vorinostat plus paclitaxel and bevacizumab in metastatic breast cancer: evidence for vorinostat-induced tubulin acetylation and Hsp90 inhibition in vivo.
Phase II trial of gemcitabine and tanespimycin (17AAG) in metastatic pancreatic cancer: a Mayo Clinic Phase II Consortium study.
Phenotypic and functional effects of heat shock protein 90 inhibition on dendritic cell.
Phenotypic identification of the redox dye methylene blue as an antagonist of heat shock response gene expression in metastatic melanoma cells.
Phosphoproteome Profiling of Isogenic Cancer Cell-Derived Exosome Reveals HSP90 as a Potential Marker for Human Cholangiocarcinoma.
Phosphorylated heat shock protein 27 represses growth of hepatocellular carcinoma via inhibition of extracellular signal-regulated kinase.
Phosphorylated Hsp27 activates ATM-dependent p53 signaling and mediates the resistance of MCF-7 cells to doxorubicin-induced apoptosis.
Phosphorylation of Ser78 of Hsp27 correlated with HER-2/neu status and lymph node positivity in breast cancer.
Phosphorylation status of heat shock protein 27 plays a key role in gemcitabine-induced apoptosis of pancreatic cancer cells.
Phosphorylation-Regulated Degradation of the Tumor-Suppressor Form of PED by Chaperone-Mediated Autophagy in Lung Cancer Cells.
Photodynamic therapy-generated cancer vaccine elicits acute phase and hormonal response in treated mice.
Photodynamic therapy-generated tumor cell lysates with CpG-oligodeoxynucleotide enhance immunotherapy efficacy in human papillomavirus 16 (E6/E7) immortalized tumor cells.
Photodynamic therapy-induced cell surface expression and release of heat shock proteins: relevance for tumor response.
Photodynamic therapy-mediated DC immunotherapy is highly effective for the inhibition of established solid tumors.
Photosensitizer Micelles Together with IDO Inhibitor Enhance Cancer Photothermal Therapy and Immunotherapy.
Photothermal response of human and murine cancer cells to multiwalled carbon nanotubes after laser irradiation.
Physical exercise induces excess hsp72 expression and delays the development of hyperalgesia and allodynia in painful diabetic neuropathy rats.
Physical localization and order of genes in the class I region of the bovine MHC.
Physical plasma-triggered ROS induces tumor cell death upon cleavage of HSP90 chaperone.
PI3K-independent mTOR activation promotes lapatinib resistance and IAP expression that can be effectively reversed by mTOR and Hsp90 inhibition.
Pifithrin-? incorporated in gold nanoparticle amplifies pro-apoptotic unfolded protein response cascades to potentiate synergistic glioblastoma therapy.
Pifithrin-alpha inhibits p53 signaling after interaction of the tumor suppressor protein with hsp90 and its nuclear translocation.
Pioglitazone, a specific ligand of peroxisome proliferator-activated receptor-gamma, accelerates gastric ulcer healing in rat.
Placenta-derived gp96 as a multivalent prophylactic cancer vaccine.
Plasma Heat Shock Protein 90 Alpha: A Valuable Predictor of Early Chemotherapy Effectiveness in Advanced Non-Small-Cell Lung Cancer.
Plasma levels of heat shock protein 90 alpha associated with lung cancer development and treatment responses.
Plasminogen kringle 5 induces apoptosis of brain microvessel endothelial cells: sensitization by radiation and requirement for GRP78 and LRP1.
Plasminogen kringle 5 suppresses gastric cancer via regulating HIF-1? and GRP78.
Platinum(iv) oxaliplatin-peptide conjugates targeting memHsp70+ phenotype in colorectal cancer cells.
PLC?1-PKC? signaling-mediated Hsp90? plasma membrane translocation facilitates tumor metastasis.
Plumbagin sensitizes breast cancer cells to tamoxifen-induced cell death through GRP78 inhibition and Bik upregulation.
Polymerase chain reaction-aided analysis of gene expression in frozen tissue sections.
Polymorphic analysis of MHClinked Heat Shock Protein 70 genes: Their susceptibility and prognostic implication in Kangri cancer cases of Kashmiri population.
Polymorphism in the tumor necrosis factor-alpha promotor region and in the heat shock protein 70 genes associated with malignant tumors.
Polymorphism of the stress protein HSP70-2 gene is associated with the susceptibility to the nasopharyngeal carcinoma.
Polymorphism of the TNF-alpha, HSP70-2, and CD14 genes increases susceptibility to severe acute pancreatitis.
Polymorphisms in the tumor necrosis factor-alpha gene at position -308 and the inducible 70 kd heat shock protein gene at position +1267 in multifetal pregnancies and preterm premature rupture of fetal membranes.
Polymorphisms in TNF and HSP-70 show a significant association with gastric cancer and duodenal ulcer.
Polymorphisms of glucose-regulated protein 78 and clinical relevance of neuroblastoma: Risk and prognosis.
Positive associations between upregulated levels of stress-induced phosphoprotein 1 and matrix metalloproteinase-9 in endometriosis/adenomyosis.
Possible effects of early treatments of hsp90 inhibitors on preventing the evolution of drug resistance to other anti-cancer drugs.
Post-transcriptional repair of a split heat shock protein 90 gene by mRNA trans-splicing.
Post-translational modification of heat-shock protein 90: impact on chaperone function.
Post-translational modifications of Hsp90 and their contributions to chaperone regulation.
Post-treatment with a heat shock protein 90 inhibitor prevents chronic lung injury and pulmonary fibrosis, following acute exposure of mice to HCl.
Posttranslational modification and conformational state of heat shock protein 90 differentially affect binding of chemically diverse small molecule inhibitors.
Potent activity of a novel dimeric heat shock protein 90 inhibitor against head and neck squamous cell carcinoma in vitro and in vivo.
Potent activity of the Hsp90 inhibitor ganetespib in prostate cancer cells irrespective of androgen receptor status or variant receptor expression.
Potent antitumor activity of HSP90 inhibitor AUY922 in adrenocortical carcinoma.
Potent antitumor activity of the novel HSP90 inhibitors AUY922 and HSP990 in neuroendocrine carcinoid cells.
Potent antitumor effect elicited by superantigen-linked tumor cells transduced with heat shock protein 70 gene.
Potent Cytotoxic C-11 Modified Geldanamycin Analogues.
Potent non-benzoquinone ansamycin heat shock protein 90 inhibitors from genetic engineering of Streptomyces hygroscopicus.
Potential C-terminal-domain inhibitors of heat shock protein 90 derived from a C-terminal peptide helix.
Potential prognostic value of heat-shock protein 90 in the presence of phosphatidylinositol-3-kinase overexpression or loss of PTEN, in invasive breast cancers.
Potential Prognostic Value of Histone Deacetylase 6 and Acetylated Heat-Shock Protein 90 in Early-Stage Breast Cancer.
Potentiation of chemotherapeutics by the Hsp90 antagonist geldanamycin requires a steady serum condition.
PRDX2 in Myocyte Hypertrophy and Survival is Mediated by TLR4 in Acute Infarcted Myocardium.
Pre-clinical safety evaluation of heat shock protein 65-MUC1 peptide fusion protein.
Preclinical activity profile and therapeutic efficacy of the HSP90 inhibitor ganetespib in triple-negative breast cancer.
Preclinical antitumor activity and pharmacodynamic studies with the farnesyl protein transferase inhibitor R115777 in human breast cancer.
Preclinical antitumor activity of SST0116CL1: a novel heat shock protein 90 inhibitor.
Preclinical antitumor activity of the novel heat shock protein 90 inhibitor CH5164840 against human epidermal growth factor receptor 2 (HER2)-overexpressing cancers.
Preclinical antitumor activity of the orally available heat shock protein 90 inhibitor NVP-BEP800.
Preclinical evaluation of the Hsp90 inhibitor SNX-5422 in ibrutinib resistant CLL.
Preclinical pharmacokinetics and metabolism of a novel diaryl pyrazole resorcinol series of heat shock protein 90 inhibitors.
Preclinical toxicity of a geldanamycin analog, 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin (17-DMAG), in rats and dogs: potential clinical relevance.
Predicting drug susceptibility of non-small cell lung cancers based on genetic lesions.
Prediction of new Hsp90 inhibitors based on 3,4-isoxazolediamide scaffold using QSAR study, molecular docking and molecular dynamic simulation.
Preferential sensitization of tumor cells to radiation by heat shock protein 90 inhibitor geldanamycin.
Preoperative heat shock protein 47 levels identify colorectal cancer patients with lymph node metastasis and poor prognosis.
Preparation of a heat-shock protein 70-based vaccine from DC-tumor fusion cells.
Presence of heat shock protein 47-positive fibroblasts in cancer stroma is associated with increased risk of postoperative recurrence in patients with lung cancer.
Presence of MLH1 protein aggravates the potential of the HSP90 inhibitor radicicol to sensitize tumor cells to cisplatin.
Preventing tumor progression to the bone by induced tumor-suppressing MSCs.
Prevention of brefeldin A-induced resistance to teniposide by the proteasome inhibitor MG-132: involvement of NF-kappaB activation in drug resistance.
Prevention of Doxorubicin cardiopathic changes by a benzyl styryl sulfone in mice.
Preventive and therapeutic effect of tumor derived heat shock protein, gp96, in an experimental prostate cancer model.
Preventive effect of phytoglycoprotein (27 kDa) on inflammatory factors at liver injury in cadmium chloride-exposed ICR mice.
Preventive effect of phytoglycoprotein (27?kDa) on inflammatory factors at liver injury in cadmium chloride-exposed ICR mice.
Primary cell cultures arising from normal kidney and renal cell carcinoma retain the proteomic profile of corresponding tissues.
Primary glioblastoma multiforme tumors and recurrence : Comparative analysis of the danger signals HMGB1, HSP70, and calreticulin.
Priming of Anti-tumor Immune Mechanisms by Radiotherapy Is Augmented by Inhibition of Heat Shock Protein 90.
Priming polyvalent immunity by DNA vaccines expressing chimeric antigens with a stress protein-capturing, viral J-domain.
PRKD2: A two-pronged kinase crucial for the tumor-supporting activity of HSP90.
PRMT6 deficiency induces autophagy in hostile microenvironments of hepatocellular carcinoma tumors by regulating BAG5-associated HSC70 stability.
Proapoptotic Cyclic Peptide BC71 Targets Cell-Surface GRP78 and Functions as an Anticancer Therapeutic in Mice.
Proapoptotic role of Hsp90 by its interaction with c-Jun N-terminal kinase in lipid rafts in edelfosine-mediated antileukemic therapy.
Probing molecular mechanisms of the Hsp90 chaperone: biophysical modeling identifies key regulators of functional dynamics.
Probing the ATP Site of GRP78 with Nucleotide Triphosphate Analogs.
Production of a Mouse Monoclonal Antibody Against Mortalin by Whole Cell Immunization.
Production of heat shock proteins, cytokines, and nitric oxide in toxic stress.
Profiling Hsp90 differential expression and the molecular effects of the Hsp90 inhibitor IPI-504 in high-grade glioma models.
Profiling protein markers associated with the sensitivity to concurrent chemoradiotherapy in human cervical carcinoma.
Progesterone receptor chaperone complex-based high-throughput screening assay: identification of capsaicin as an inhibitor of the Hsp90 machine.
Prognostic evaluation of p53, heat shock protein 70, Ki67, and CD34 expression in cancer of the tongue in Tunisia.
Prognostic role of BiP/GRP78 expression as ER stress in patients with gastric adenocarcinoma.
Prognostic significance of GRP78 expression patterns in breast cancer patients receiving adjuvant chemotherapy.
Prognostic significance of heat shock protein 105 in lung adenocarcinoma.
Prognostic significance of heat shock protein 70 expression in early gastric carcinoma.
Prognostic significance of heat shock protein 90AA1 (HSP90?) in invasive breast cancer.
Prognostic significance of heat shock proteins HSP70 and HSP90 in endometrial carcinomas.
Prognostic Significance of the Hsp70 Gene Family in Colorectal Cancer.
Prognostic value of Mortalin correlates with roles in epithelial-mesenchymal transition and angiogenesis in lung adenocarcinoma.
Progression of the role of CRYAB in signaling pathways and cancers.
Prohibitin 1 suppresses liver cancer tumorigenesis in mice and human hepatocellular and cholangiocarcinoma cells.
Prolonged Endoplasmic Reticulum-Stressed Hepatocytes Drive an Alternative Macrophage Polarization.
Promising Targets and Current Clinical Trials in Metastatic Non-Squamous NSCLC.
Prophylactic Antitumor Effect of Mixed Heat Shock Proteins/Peptides in Mouse Sarcoma.
Prospective identification of resistance mechanisms to HSP90 inhibition in KRAS mutant cancer cells.
Prostate cancer serum biomarker discovery through proteomic analysis of alpha-2 macroglobulin protein complexes.
Proteasome inhibitors differentially affect heat shock protein response in cancer cells.
Protection of zinc against tumor necrosis factor induced lethal inflammation depends on heat shock protein 70 and allows safe antitumor therapy.
Protective antitumor immunity induced by tumor cell lysates conjugated with diphtheria toxin and adjuvant epitope in mouse breast tumor models.
Protective effect of gentiopicroside from Gentiana macrophylla Pall. in ethanol-induced gastric mucosal injury in mice.
Protective Effect of Naringenin against Lipopolysaccharide-Induced Acute Lung Injury in Rats.
Protective effect of resveratrol against hepatic damage induced by heat stress in a rat model is associated with the regulation of oxidative stress and inflammation.
Protective effects of noradrenaline against tumor necrosis factor-alpha-induced apoptosis in cultured rat brown adipocytes: role of nitric oxide-induced heat shock protein 70 expression.
Protective role of Hsp27 protein against gamma radiation-induced apoptosis and radiosensitization effects of Hsp27 gene silencing in different human tumor cells.
Protein chaperones: a composition of matter review (2008 - 2013).
Protein expression during lag phase and growth initiation in Saccharomyces cerevisiae.
Protein Expression Profile using Two-Dimensional Gel Analysis in Squamous Cervical Cancer Patients.
Protein expression profiling in the spectrum of renal cell carcinomas.
Protein kinase C delta regulates the phosphorylation of heat shock protein 27 in human hepatocellular carcinoma.
Protein profile changes in the human breast cancer cell line MCF-7 in response to SEL1L gene induction.
Protein profile of MCF-7 breast cancer cell line treated with lectin delivered by CaCO3NPs revealed changes in molecular chaperones, cytoskeleton, and membrane-associated proteins.
Proteins of the Nucleolus of Dictyostelium discoideum: Nucleolar Compartmentalization, Targeting Sequences, Protein Translocations and Binding Partners.
Proteome analysis and functional expression identify mortalin as an antiapoptotic gene induced by elevation of [Na+]i/[K+]i ratio in cultured vascular smooth muscle cells.
Proteome analysis of metastatic colorectal cancer cells recognized by the lectin Helix pomatia agglutinin (HPA).
Proteome analysis reveals novel proteins associated with proliferation and differentiation of the colorectal cancer cell line Caco-2.
Proteome changes in caco-2 cells treated with monascus-fermented red mold rice extract.
Proteome changes in ovarian epithelial cells derived from women with BRCA1 mutations and family histories of cancer.
Proteome-wide analysis of head and neck squamous cell carcinomas using laser-capture microdissection and tandem mass spectrometry.
Proteomic analysis in endometrial cancer and endometrial hyperplasia tissues by 2D-DIGE technique.
Proteomic analysis of cancer tissues: shedding light on carcinogenesis and possible biomarkers.
Proteomic analysis of proteome and histone post-translational modifications in heat shock protein 90 inhibition-mediated bladder cancer therapeutics.
Proteomic analysis of the copper ion-induced stress response in a human embryonic carcinoma cell line.
Proteomic analysis of vascular smooth muscle cells treated with ouabain.
Proteomic and Functional Analyses Reveal a Dual Molecular Mechanism Underlying Arsenic-Induced Apoptosis in Human Multiple Myeloma Cells.
Proteomic and PROTEOMEX profiling of mammary cancer progression in a HER-2/neu oncogene-driven animal model system.
Proteomic characterization of pancreatic islet {beta}-cells stimulated with pancreatic carcinoma cell conditioned medium.
Proteomic detection of changes in protein synthesis induced by fibroblast growth factor-2 in MCF-7 human breast cancer cells.
Proteomic identification and characterization of Ctenopharyngodon idella tumor necrosis factor receptor-associated protein 1 (CiTrap1): An anti-apoptosis factor upregulated by grass carp reovirus infection.
Proteomic interrogation of HSP90 and insights for medical research.
Proteomic investigation of anti-tumor activities exerted by sinularin against A2058 melanoma cells.
Proteomic investigation of human burn wounds by 2D-difference gel electrophoresis and mass spectrometry.
Proteomic Profile of Sorafenib Resistance in Hepatocellular Carcinoma; GRP78 Expression Is Associated With Inferior Response to Sorafenib.
Proteomic profiling of hepatocellular carcinoma in Chinese cohort reveals heat-shock proteins (Hsp27, Hsp70, GRP78) up-regulation and their associated prognostic values.
Proteomic profiling of murine oocyte maturation.
Proteomic profiling of the effect of prostate-specific antigen on prostate cancer cells.
Proteomic profiling reveals that resveratrol inhibits HSP27 expression and sensitizes breast cancer cells to doxorubicin therapy.
Proteomics-based identification of HSP60 as a tumor-associated antigen in colorectal cancer.
Proteomics-based identification of HSP60 as a tumor-associated antigen in early stage breast cancer and ductal carcinoma in situ.
Proteotoxic stress targeted therapy (PSTT): induction of protein misfolding enhances the antitumor effect of the proteasome inhibitor bortezomib.
Proton MRS detects metabolic changes in hormone sensitive and resistant human prostate cancer models CWR22 and CWR22r.
Pten null prostate tumorigenesis and AKT activation are blocked by targeted knockout of ER chaperone GRP78/BiP in prostate epithelium.
Pterostilbene in Cancer Therapy.
Pterostilbene-induced tumor cytotoxicity: a lysosomal membrane permeabilization-dependent mechanism.
PTHrP [67-86] regulates the expression of stress proteins in breast cancer cells inducing modifications in urokinase-plasminogen activator and MMP-1 expression.
Pu-erh Tea Inhibits Tumor Cell Growth by Down-Regulating Mutant p53.
PU-H71 effectively induces degradation of I?B kinase ? in the presence of TNF-?.
PU-H71, a novel Hsp90 inhibitor, as a potential cancer-specific sensitizer to carbon-ion beam therapy.
Puerarin enhances intestinal function in piglets infected with porcine epidemic diarrhea virus.
Purification of complexes of nuclear oncogene p53 with rat and Escherichia coli heat shock proteins: in vitro dissociation of hsc70 and dnaK from murine p53 by ATP.
Purification of heat shock protein 70-associated tumor peptides and their antitumor immunity to hepatoma in mice.
Purification of multiple heat shock proteins from a single tumor sample.
Purification of proteins for crystallographic applications.
Purine-scaffold Hsp90 inhibitors.
Purine-Scaffold Hsp90 Inhibitors.
Pyruvate kinase M2 and the mitochondrial ATPase Inhibitory Factor 1 provide novel biomarkers of dermatomyositis: a metabolic link to oncogenesis.
Quantitative analysis of hormones and inflammatory cytokines in Chlamydia trachomatis-infected women with tubal ectopic pregnancy and early intrauterine pregnancy.
Quantitative analysis of the interplay between hsc70 and its co-chaperone HspBP1.
Quantitative assessment of hsp70, IL-1? and TNF-? in the spinal cord of dogs with E40K SOD1-associated degenerative myelopathy.
Quantitative patterns of Hsps in tubular adenoma compared with normal and tumor tissues reveal the value of Hsp10 and Hsp60 in early diagnosis of large bowel cancer.
Quantitative proteomic analysis shows differentially expressed HSPB1 in glioblastoma as a discriminating short from long survival factor and NOVA1 as a differentiation factor between low-grade astrocytoma and oligodendroglioma.
Quantitative proteomics reveals molecular mechanism of gamabufotalin and its potential inhibition on Hsp90 in lung cancer.
Quantitative proteomics reveals that hsp90 inhibition preferentially targets kinases and the DNA damage response.
Quantitative score modulation of HSP90 and HSP27 in clear cell renal cell carcinoma.
Quantum dot-based mortalin staining as a visual assay for detection of induced senescence in cancer cells.
Quercetin Enhances Chemosensitivity to Gemcitabine in Lung Cancer Cells by Inhibiting Heat Shock Protein 70 Expression.
Quercetin Mediated Reduction of Angiogenic Markers and Chaperones in DLA-Induced Solid Tumours.
Quercetin sensitizes cells in a tumour-like low pH environment to hyperthermia.
Quercetin-Induced Cell Death in Human Papillary Thyroid Cancer (B-CPAP) Cells.
Quinazoline Based HSP90 Inhibitors: Synthesis, Modeling Study and ADME Calculations Towards Breast Cancer Targeting.
Radanamycin, a macrocyclic chimera of radicicol and geldanamycin.
Radiation combined with hyperthermia induces HSP70-dependent maturation of dendritic cells and release of pro-inflammatory cytokines by dendritic cells and macrophages.
Radiation treatment of acute inflammation in mice.
Radicicol potentiates heat-induced cell killing in a human oesophageal cancer cell line: the Hsp90 chaperone complex as a new molecular target for enhancement of thermosensitivity.
Radicicol, an inhibitor of Hsp90, enhances TRAIL-induced apoptosis in human epithelial ovarian carcinoma cells by promoting activation of apoptosis-related proteins.
Radioactive iodine labeling of monoclonal antibody against Hsp90? and its use in diagnostic imaging in prostate cancer xenograft model.
Radiochemotherapy combined with NK cell transfer followed by second-line PD-1 inhibition in a patient with NSCLC stage IIIb inducing long-term tumor control: a case study.
Radiofrequency ablation combined with liposomal quercetin to increase tumour destruction by modulation of heat shock protein production in a small animal model.
Radioresistant human lung adenocarcinoma cells that survived multiple fractions of ionizing radiation are sensitive to HSP90 inhibition.
Radiosensitization of human lung cancer cells by the novel purine-scaffold Hsp90 inhibitor, PU-H71.
Radiosensitization of normoxic and hypoxic h1339 lung tumor cells by heat shock protein 90 inhibition is independent of hypoxia inducible factor-1?.
Radiosensitization of wildtype p53 cancer cells by the MDM2-inhibitor PXN727 is associated with altered heat shock protein 70 (Hsp70) levels.
Radiosensitizing effect of the novel Hsp90 inhibitor NVP-AUY922 in human tumour cell lines silenced for Hsp90?.
Radiosynthesis of the iodine-124 labeled Hsp90 inhibitor PU-H71.
Radiosynthesis of [(18)F]fluoromethyldeoxyspergualin for molecular imaging of heat shock proteins.
Radiosynthesis, biological evaluation and preliminary microPET study of 18F-labeled 5-resorcinolic triazolone derivative based on ganetespib targeting HSP90.
Rapid labelling and covalent inhibition of intracellular native proteins using ligand-directed N-acyl-N-alkyl sulfonamide.
Rapid synthesis of a Bi@ZIF-8 composite nanomaterial as a near-infrared-II (NIR-II) photothermal agent for the low-temperature photothermal therapy of hepatocellular carcinoma.
Rational Design of Allosteric and Selective Inhibitors of the Molecular Chaperone TRAP1.
Rational design of shepherdin, a novel anticancer agent.
Rationally designed high-affinity 2-amino-6-halopurine heat shock protein 90 inhibitors that exhibit potent antitumor activity.
Re: First-in-Human Phase I Dose Escalation Study of a Second-Generation Non-Ansamycin HSP90 Inhibitor, AT13387, in Patients with Advanced Solid Tumors.
Reaction of Geldanamycin and C17-Substituted Analogues with Glutathione: Product Identifications and Pharmacological Implications.
Reactivity of gamma delta T cells induced by the tumour cell line RPMI 8226: functional heterogeneity of clonal populations and role of GroEL heat shock proteins.
Rebalancing Protein Homeostasis Enhances Tumor Antigen Presentation.
Recent advances in heat shock protein-based cancer vaccines.
Recent advances in Hsp90 inhibitors as antitumor agents.
Recent Advances in Stereoselective Drug Targeting.
Recent Advances in the Discovery of Novel HSP90 Inhibitors: An Update from 2014.
Recent Patents on Heat Shock Proteins Targeting Antibodies.
Recent update on discovery and development of Hsp90 inhibitors as senolytic agents.
Recent updates on the development of ganetespib as a Hsp90 inhibitor.
Receptor-recognized ??-macroglobulin binds to cell surface-associated GRP78 and activates mTORC1 and mTORC2 signaling in prostate cancer cells.
Recognition and killing of tumour cells expressing heat shock protein 65 kD with immunotoxins containing saporin.
Recombinant adeno-associated virus encoding Epstein-Barr virus latent membrane proteins fused with heat shock protein as a potential vaccine for nasopharyngeal carcinoma.
Recombinant adeno-associated virus expressing human papillomavirus type 16 E7 peptide DNA fused with heat shock protein DNA as a potential vaccine for cervical cancer.
Recombinant heat shock protein 70 in combination with radiotherapy as a source of tumor antigens to improve dendritic cell immunotherapy.
Recombinant Production and Characterization of SAC, the Core Domain of Par-4, by SUMO Fusion System.
Reconstitution of the mitochondrial Hsp70 (mortalin)-p53 interaction using purified proteins--identification of additional interacting regions.
Reconstructed mung bean trypsin inhibitor targeting cell surface GRP78 induces apoptosis and inhibits tumor growth in colorectal cancer.
Redox modulation of vitagenes via plant polyphenols and vitamin D: Novel insights for chemoprevention and therapeutic interventions based on organoid technology.
Reduced Contractility and Motility of Prostatic Cancer-Associated Fibroblasts after Inhibition of Heat Shock Protein 90.
Reduced levels of Hspa9 attenuate Stat5 activation in mouse B cells.
Reduced Number of Lymphocytes by X-ray Irradiation: A Problem in a Combination Therapy Trial that Elicits the Abscopal Effect in Preclinical Studies Using Electron Beam Irradiation.
Reduced survivin expression and tumor cell survival during chronic hypoxia and further cytotoxic enhancement by the cyclooxygenase-2 inhibitor celecoxib.
Reflections and Outlook on Targeting HSP90, HSP70 and HSF1 in Cancer: A Personal Perspective.
Regression of intestinal adenomas by vaccination with heat shock protein 105-pulsed bone marrow-derived dendritic cells in Apc(Min/+) mice.
Regulating the cytoprotective response in cancer cells using simultaneous inhibition of Hsp90 and Hsp70.
Regulation of CD23 in the chronic inflammatory response in asthma: a role for interferon-gamma and heat shock protein 70 in the TH2 environment.
Regulation of heat shock protein 70 gene expression by c-myc.
Regulation of Hsp90 client proteins by a Cullin5-RING E3 ubiquitin ligase.
Regulation of proliferation and gene expression in cultured human aortic smooth muscle cells by resveratrol and standardized grape extracts.
Regulation of the EGFR Pathway by HSP90 Is Involved in the Pathogenesis of Cushing's Disease.
Regulation of tumor angiogenesis by oxygen-regulated protein 150, an inducible endoplasmic reticulum chaperone.
Regulation of tumor cell mitochondrial homeostasis by an organelle-specific hsp90 chaperone network.
Regulation of Ubiquitin-like with Plant Homeodomain and RING Finger Domain 1 (UHRF1) Protein Stability by Heat Shock Protein 90 Chaperone Machinery.
Regulatory processes affecting androgen receptor expression, stability, and function: potential targets to treat hormone-refractory prostate cancer.
Relationship between 90-kilodalton heat shock protein, estrogen receptor, and progesterone receptor in human mammary tumors.
Relationship between defective mouse mammary tumor virus envelope glycoprotein synthesis and GRP78 synthesis in glucocorticoid-treated mouse lymphoma cells. Evidence for translational control of GRP78 synthesis.
Relevance of mortalin to cancer cell stemness and cancer therapy.
Reliability of HSP70 (HSPA) expression as a prognostic marker in glioma.
Reliability of tumor markers, chemokines, and metastasis-related molecules in serum.
Removing the cells from adult bone marrow derived stem cell therapy does not eliminate cardioprotection.
Repercussion of Mitochondria Deformity Induced by Anti-Hsp90 Drug 17AAG in Human Tumor Cells.
Repositioning of Verrucosidin, a purported inhibitor of chaperone protein GRP78, as an inhibitor of mitochondrial electron transport chain complex I.
Reproducibility of fluid-phase measurements in PBS-treated sputum supernatant of healthy and stable COPD subjects.
Reptin drives tumour progression and resistance to chemotherapy in nonsmall cell lung cancer.
Repurposing L-Menthol for Systems Medicine and Cancer Therapeutics? L-Menthol Induces Apoptosis through Caspase 10 and by Suppressing HSP90.
Requirement for endogenous heat shock factor 1 in inducible nitric oxide synthase induction in murine microglia.
Research resource: enhanced genome-wide occupancy of estrogen receptor ? by the cochaperone p23 in breast cancer cells.
Resistance exercise training-induced muscle hypertrophy was associated with reduction of inflammatory markers in elderly women.
Resistance to HSP90 inhibition involving loss of MCL1 addiction.
Response to hepatocarcinoma hca-f of mice immunized with heat shock protein 70 from elemene combo tumor cell vaccine.
Responses to surgical stress after esophagectomy: Gene expression of heat shock protein 70, toll-like receptor 4, tumor necrosis factor-? and inducible nitric oxide synthase.
Restoration of MHC class I surface expression and endogenous antigen presentation by a molecular chaperone.
Restored expression of the atypical heat shock protein H11/HspB8 inhibits the growth of genetically diverse melanoma tumors through activation of novel TAK1-dependent death pathways.
RESULTS OF IMMUNOHISTOCHEMISTRY IN THE DIFFERENTIAL DIAGNOSIS OF EARLY HEPATOCELLULAR CARCINOMA AND NODULES WITH HIGH-GRADE DYSPLASIA IN PATIENTS WITH CIRRHOSIS.
Retinoid- and sodium-butyrate--induced decrease in heat shock protein 70 membrane-positive tumor cells is associated with reduced sensitivity to natural killer cell lysis, growth delay, and altered growth morphology.
Reversal of pancreatic desmoplasia by re-educating stellate cells with a tumour microenvironment-activated nanosystem.
Reversed expression of GRIM-1 and GRP78 in human non-small cell lung cancer.
Ring-opening of five-membered heterocycles conjugated 4-isopropylresorcinol scaffold-based benzamides as HSP90 inhibitors suppressing tumor growth in vitro and in vivo.
RNAi of Grp78 may disturb the fusion of ICR mouse palate cultured in vitro.
RNF186 regulates EFNB1 (ephrin B1)-EPHB2-induced autophagy in the colonic epithelial cells for the maintenance of intestinal homeostasis.
Role of acetylation and extracellular location of heat shock protein 90alpha in tumor cell invasion.
Role of BRCA1 in heat shock response.
Role of heat shock protein 27 in regulation of glutathione system and apoptosis of Jurkat tumor cells and blood lymphocytes.
Role of HSP60/HSP10 in Lung Cancer: Simple Biomarkers or Leading Actors?
Role of Hsp70 in cancer growth and survival.
Role of hsp90 and the hsp90-binding immunophilins in signalling protein movement.
Role of HSPA1L as a cellular prion protein stabilizer in tumor progression via HIF-1?/GP78 axis.
Role of Human and Mouse HspB1 in Metastasis.
Role of Krüppel-like factor 4 and heat shock protein 27 in cancer of the larynx.
Role of membrane Hsp70 in radiation sensitivity of tumor cells.
Role of mitochondrial network stabilisation by a human small heat shock protein in tumour malignancy.
Role of protein kinase Cdelta in transmitting hypoxia signal to HSF and HIF-1.
Role of scavenger receptors in the binding and internalization of heat shock protein 70.
Role of the novel HSP90 inhibitor AUY922 in hepatocellular carcinoma: Potential for therapy.
Role of the Unfolded Protein Response Regulator GRP78/BiP in Development, Cancer and Neurological Disorders.
Roles of GRP78 in physiology and cancer.
Roles of heat-shock protein 90 in maintaining and facilitating the neurodegenerative phenotype in tauopathies.
Romidepsin for the treatment of cutaneous T-cell lymphoma.
Rose Bengal acetate photodynamic therapy (RBAc-PDT) induces exposure and release of Damage-Associated Molecular Patterns (DAMPs) in human HeLa cells.
S-nitrosylation affects TRAP1 structure and ATPase activity and modulates cell response to apoptotic stimuli.
Safety and activity of IT-139, a ruthenium-based compound, in patients with advanced solid tumours: a first-in-human, open-label, dose-escalation phase I study with expansion cohort.
SAHA shows preferential cytotoxicity in mutant p53 cancer cells by destabilizing mutant p53 through inhibition of the HDAC6-Hsp90 chaperone axis.
Salvianolic acid A inhibits tumor-associated angiogenesis by blocking GRP78 secretion.
Screening of cytokines to enhance vaccine effects of heat shock protein 70-rich tumor cell lysate.
Second-Generation HSP90 Inhibitor Onalespib Blocks mRNA Splicing of Androgen Receptor Variant 7 in Prostate Cancer Cells.
Secreted GRP78 activates EGFR-SRC-STAT3 signaling and confers the resistance to sorafeinib in HCC cells.
Secreted heat shock protein 90 promotes prostate cancer stem cell heterogeneity.
Secreted heat shock protein 90alpha induces colorectal cancer cell invasion through CD91/LRP-1 and NF-kappaB-mediated integrin alphaV expression.
Secreted heat shock protein gp96-Ig: next-generation vaccines for cancer and infectious diseases.
Secreted heat shock protein-90 (Hsp90) in wound healing and cancer.
Secreted Hsp90 is a novel regulator of the epithelial to mesenchymal transition (EMT) in prostate cancer.
Secretion of cytokines and heat shock protein (HspA1A) by ovarian cancer cells depending on the tumor type and stage of disease.
Secretion of extracellular hsp90alpha via exosomes increases cancer cell motility: a role for plasminogen activation.
Secretory Clusterin: A Promising Target for Chemoresistance of Hepatocellular Carcinoma.
Secretory prostate apoptosis response (Par)-4 sensitizes multicellular spheroids (MCS) of glioblastoma multiforme cells to tamoxifen-induced cell death.
Selection and Characterization of Single Chain Antibody Fragments Specific for Hsp90 as a Potential Cancer Targeting Molecule.
Selection of phage-displayed accessible recombinant targeted antibodies (SPARTA): methodology and applications.
Selective cancer targeting via aberrant behavior of cancer cell-associated glucocorticoid receptor.
Selective cytotoxic activity of valinomycin against HT-29 Human colon carcinoma cells via down-regulation of GRP78.
Selective Cytotoxicity of Ponciri Fructus against Glucose-Deprived PANC-1 Human Pancreatic Cancer Cells via Blocking Activation of GRP78.
Selective depletion of heat shock protein 70 (Hsp70) activates a tumor-specific death program that is independent of caspases and bypasses Bcl-2.
Selective depletion of inducible HSP70 enhances immunogenicity of rat colon cancer cells.
Selective expression of immunogenic, virus-like particle-derived antibody-binding epitopes.
Selective HSP90? inhibition results in TNF and TRAIL mediated HIF1? degradation.
Selective Inhibition of the Hsp90? Isoform.
Selective targeting of cancer cells using a hydrogen peroxide-activated Hsp90 inhibitor.
Selective toxicity of MKT-077 to cancer cells is mediated by its binding to the hsp70 family protein mot-2 and reactivation of p53 function.
Selenomethionine relieves inflammation in the chicken trachea caused by LPS though inhibiting the NF-?B pathway.
Self-heat shock protein 60 induces tumour necrosis factor-alpha in monocyte-derived macrophage: possible role in chronic inflammatory periodontal disease.
Senescence-associated HSP60 expression in normal human skin fibroblasts.
Sensitization of (colon) cancer cells to death receptor related therapies: A report from the FP6-ONCODEATH research consortium.
Sensitization of lung cancer cells by altered dimerization of HSP27.
Sensitization of multidrug-resistant cancer cells to Hsp90 inhibitors by NSAIDs-induced apoptotic and autophagic cell death.
Sensitization of multidrug-resistant human cancer cells to Hsp90 inhibitors by down-regulation of SIRT1.
Sensitization of TRAIL-resistant cells by inhibition of heat shock protein 90 with low-dose geldanamycin.
Sensitizing tumor cells to radiation by targeting the heat shock response.
Separation and identification of HSP-associated protein complexes from pancreatic cancer cell lines using 2D CN/SDS-PAGE coupled with mass spectrometry.
Sequences in the HSP90 promoter form G-quadruplex structures with selectivity for disubstituted phenyl bis-oxazole derivatives.
Serine/Threonine Kinase Unc-51-like Kinase-1 (Ulk1) Phosphorylates the Co-chaperone Cell Division Cycle Protein 37 (Cdc37) and Thereby Disrupts the Stability of Cdc37 Client Proteins.
Serum antibodies to the 27-kd heat shock protein in women with gynecologic cancers.
Serum antibody response to the heat shock protein 60 of Chlamydia trachomatis in women with developing cervical cancer.
Serum GRP78 as a Tumor Marker and Its Prognostic Significance in Non-Small Cell Lung Cancers: A Retrospective Study.
Serum heat shock protein 27 is increased in chronic pancreatitis and pancreatic carcinoma.
Serum heat shock protein 27 levels in patients with hepatocellular carcinoma.
Serum heat shock protein 70 levels and lung cancer risk: a case-control study nested in a large cohort study.
Serum heat shock protein 90 as a future predictive biomarker in childhood acute lymphoblastic leukemia.
Serum level of soluble 70-kD heat shock protein is associated with high mortality in patients with colorectal cancer without distant metastasis.
Serum levels of anti-heat shock protein 27 antibodies in patients with chronic liver disease.
Serum levels of HSP90 in the continuum of breast ductal and lobular lesions.
Serum Tumor Markers for Early Diagnosis of Primary Hepatocellular Carcinoma.
Severe, but not mild heat-shock treatment induces immunogenic cell death in cancer cells.
Sex differences play a role in cardiac endoplasmic reticulum stress (ERS) and ERS-initiated apoptosis induced by pressure overload and thapsigargin.
sFLT01 modulates invasion and metastasis in prostate cancer DU145 cells by inhibition of VEGF/GRP78/MMP2&9 axis.
SHetA2 interference with mortalin binding to p66shc and p53 identified using drug-conjugated magnetic microspheres.
Shock block for improved immunotherapy.
Shock the heat shock network.
Short-hairpin RNA-mediated Heat shock protein 90 gene silencing inhibits human breast cancer cell growth in vitro and in vivo.
Short-Wave Diathermy Pretreatment and Inflammatory Myokine Response After High-Intensity Eccentric Exercise.
ShRNA-mediated gene silencing of Heat shock protein 70 inhibits human colon cancer cell growth in vitro and in vivo.
ShRNA-mediated gene silencing of heat shock protein 70 inhibits human colon cancer growth.
Sialic acid content of tissue specific gp96 and its potential role in modulating gp96-macrophage interactions.
Sigma-1 Receptor Positron Emission Tomography: A New Molecular Imaging Approach Using (S)-(-)-[18F]Fluspidine in Glioblastoma.
Signalling profile and antitumour activity of the novel Hsp90 inhibitor NVP-AUY922 in multiple myeloma.
Significance of expression of heat shock protein90alpha in human gastric cancer.
Significance of serum antibodies against HSP 60 and HSP 70 for the diagnostic of infectious diseases.
Sildenafil triggers tumor lethality through altered expression of HSP90 and degradation of PKD2.
Silence of HDAC6 suppressed esophageal squamous cell carcinoma proliferation and migration by disrupting chaperone function of HSP90.
Silencing glucose-regulated protein 78 induced renal cell carcinoma cell line G1 cell-cycle arrest and resistance to conventional chemotherapy.
Silencing heat shock protein 27 decreases metastatic behavior of human head and neck squamous cell cancer cells in vitro.
Silencing of Glucose-Regulated Protein 78 (GRP78) Enhances Cell Migration Through the Upregulation of Vimentin in Hepatocellular Carcinoma Cells.
Silencing the cochaperone CDC37 destabilizes kinase clients and sensitizes cancer cells to HSP90 inhibitors.
Silencing the hsp25 gene eliminates migration capability of the highly metastatic murine 4T1 breast adenocarcinoma cell.
Simultaneous binding of the anti-cancer IgM monoclonal antibody PAT-SM6 to low density lipoproteins and GRP78.
Simultaneous detection of porcine cytokines by multiplex analysis: Development of magnetic bioplex assay.
Simvastatin functions as a heat shock protein 90 inhibitor against triple-negative breast cancer.
Single-cell RNA sequencing reveals that targeting HSP90 suppresses PDAC progression by restraining mitochondrial bioenergetics.
Six weeks of voluntary wheel running modulates inflammatory protein (MCP-1, IL-6, and IL-10) and DAMP (Hsp72) responses to acute stress in white adipose tissue of lean rats.
Small Heat Shock Protein as a Multifunctional Scaffold: Integrated Tumor Targeting and Caspase Imaging within a Single Cage.
Small interfering RNA targeting heat shock protein 70 enhances chemosensitivity in human bladder cancer cells.
Small molecule inhibitor screening identifified HSP90 inhibitor 17-AAG as potential therapeutic agent for gallbladder cancer.
Small Molecule Inhibitors to Disrupt Protein-protein Interactions of Heat Shock Protein 90 Chaperone Machinery.
Small molecule modulators of endogenous and co-chaperone-stimulated Hsp70 ATPase activity.
Small-Animal PET Imaging of Pancreatic Cancer Xenografts Using a 64Cu-Labeled Monoclonal Antibody, MAb159.
Small-molecule inhibitor targeting the Hsp90-Cdc37 protein-protein interaction in colorectal cancer.
Small-molecule targeting of heat shock protein 90 chaperone function: rational identification of a new anticancer lead.
SMR peptide antagonizes mortalin promoted release of extracellular vesicles and affects mortalin protection from complement-dependent cytotoxicity in breast cancer cells and leukemia cells.
SMYD2-dependent HSP90 methylation promotes cancer cell proliferation by regulating the chaperone complex formation.
SNP discovery and gene annotation in the surf clam Mesodesma donacium
SNX-2112 Induces Apoptosis and Autophagy of Nara-H Cells.
SNX-2112, a selective Hsp90 inhibitor, potently inhibits tumor cell growth, angiogenesis, and osteoclastogenesis in multiple myeloma and other hematologic tumors by abrogating signaling via Akt and ERK.
SNX-25a, a novel Hsp90 inhibitor, inhibited human cancer growth more potently than 17-AAG.
SNX2112, a synthetic heat shock protein 90 inhibitor, has potent antitumor activity against HER kinase-dependent cancers.
Solid lipid nanoparticles as a novel formulation approach for tanespimycin (17-AAG) against leishmania infections: Preparation, characterization and macrophage uptake.
Solid-phase synthesis, characterization and RNAi activity of branch and hyperbranch siRNAs.
Soluble B and T lymphocyte attenuator possesses antitumor effects and facilitates heat shock protein 70 vaccine-triggered antitumor immunity against a murine TC-1 cervical cancer model in vivo.
Soluble guanylyl cyclase requires heat shock protein 90 for heme insertion during maturation of the NO-active enzyme.
Soluble heat-shock protein 27 in blood serum is a non-invasive prognostic biomarker for ovarian cancer.
Soluble T cell immunoglobulin mucin domain 3 (sTim-3) in maternal sera: a potential contributor to immune regulation during pregnancy.
Solution structure of the Hop TPR2A domain and investigation of target druggability by NMR, biochemical and in silico approaches.
Somatic mutations of calreticulin in myeloproliferative neoplasms.
Sp1 regulates Raf/MEK/ERK-induced p21(CIP1) transcription in TP53-mutated cancer cells.
Spatiofunctional Dynamics of NKX3.1 to Safeguard the Prostate from Cancer.
Specific peptides for the therapeutic targeting of oncogenes.
Specific protein carbonylation in human breast cancer tissue compared to adjacent healthy epithelial tissue.
Specific regulation of HSPs in human tumor cell lines by PSK.
Sperm protein 17 is a novel marker for predicting cisplatin response in esophageal squamous cancer cell lines.
Spirulina phycocyanin induces differential protein expression and apoptosis in SKOV-3 cells.
Spontaneous and controllable activation of suicide gene expression driven by the stress-inducible grp78 promoter resulting in eradication of sizable human tumors.
Spotlight on 17-AAG as an Hsp90 inhibitor for molecular targeted cancer treatment.
Spotlight on the microbes that produce heat shock protein 90-targeting antibiotics.
STA-8666, a novel HSP90 inhibitor/SN-38 drug conjugate, causes complete tumor regression in preclinical mouse models of pediatric sarcoma.
STA-9090, a small-molecule Hsp90 inhibitor for the potential treatment of cancer.
Stage 1 testing and pharmacodynamic evaluation of the HSP90 inhibitor alvespimycin (17-DMAG, KOS-1022) by the pediatric preclinical testing program.
Steady-State Levels of Phosphorylated Mitogen-Activated Protein Kinase Kinase 1/2 Determined by Mortalin/HSPA9 and Protein Phosphatase 1 Alpha in KRAS and BRAF Tumor Cells.
Stereospecific antitumor activity of radicicol oxime derivatives.
Steroids from Helleborus caucasicus reduce cancer cell viability inducing apoptosis and GRP78 down-regulation.
STI571 (Glivec) inhibits the interaction between c-KIT and heat shock protein 90 of the gastrointestinal stromal tumor cell line, GIST-T1.
Stimulation of erythrocyte cell membrane scrambling by gedunin.
Stimulation of the ATPase activity of Hsp90 by zerumbone modification of its cysteine residues destabilizes its clients and causes cytotoxicity.
STK33 participates to HSP90-supported angiogenic program in hypoxic tumors by regulating HIF-1?/VEGF signaling pathway.
Stomatin-Mediated Inhibition of the Akt Signaling Axis Suppresses Tumor Growth.
Strategies for Stalling Malignancy: Targeting Cancer's Addiction to Hsp90.
Strategy of Virtual Screening Based Discovery of HSP90 C-terminal Inhibitors and Network Pharmacological Analysis.
Stress and immune responses in skin of turbot (Scophthalmus maximus) under different stocking densities.
Stress Augments Insulin Resistance and Prothrombotic State: Role of Visceral Adipose-Derived Monocyte Chemoattractant Protein-1.
Stress Chaperone GRP-78 Functions in Mineralized Matrix Formation.
Stress chaperone GRP78/BiP confers chemoresistance to tumor-associated endothelial cells.
Stress chaperone mortalin contributes to epithelial-mesenchymal transition and cancer metastasis.
Stress chaperones, mortalin, and pex19p mediate 5-aza-2' deoxycytidine-induced senescence of cancer cells by DNA methylation-independent pathway.
Stress granule formation mediates the inhibition of colonic Hsp70 translation by interferon-gamma and tumor necrosis factor-alpha.
Stress Induction of GRP78/BiP and Its Role in Cancer.
Stress protein GRP78 prevents apoptosis induced by calcium ionophore, ionomycin, but not by glycosylation inhibitor, tunicamycin, in human prostate cancer cells.
Stress protein Hsp27 expression predicts the outcome in operated small cell lung carcinoma and large cell neuroendocrine carcinoma patients.
Stress protein/peptide complexes derived from autologous tumor tissue as tumor vaccines.
Stress Proteins and Cytokines are Urinary Biomarkers for Diagnosis and Staging of Bladder Cancer.
Stress-induced phosphoprotein-1 maintains the stability of JAK2 in cancer cells.
Stress-induced release of HSC70 from human tumors.
Strong antitumor synergy between DNA crosslinking and HSP90 inhibition causes massive premitotic DNA fragmentation in ovarian cancer cells.
Structural analysis of the interaction between Hsp90 and the tumor suppressor protein p53.
Structural and Computational Biology of the Molecular Chaperone Hsp90: from Understanding Molecular Mechanisms to Computer-Based Inhibitor Design.
Structural and energetic insight into the interactions between the benzolactam inhibitors and tumor marker HSP90?.
Structural and functional basis of protein phosphatase 5 substrate specificity.
Structural basis for depletion of heat shock protein 90 client proteins by deguelin.
Structural Basis for Design of New Purine-Based Inhibitors Targeting the Hydrophobic Binding Pocket of Hsp90.
Structural basis of the radicicol resistance displayed by a fungal hsp90.
Structural Determination of Three Different Series of Compounds as Hsp90 Inhibitors Using 3D-QSAR Modeling, Molecular Docking and Molecular Dynamics Methods.
Structural ensemble-based docking simulation and biophysical studies discovered new inhibitors of Hsp90 N-terminal domain.
Structural insights into tumor-specific chaperoning activity of gamma synuclein in protecting estrogen receptor alpha 36 and its role in tamoxifen resistance in breast cancer.
Structural studies of UBXN2A and mortalin interaction and the putative role of silenced UBXN2A in preventing response to chemotherapy.
Structure based design of heat shock protein 90 inhibitors acting as anticancer agents.
Structure of the ATP-binding domain of Plasmodium falciparum Hsp90.
Structure prediction, expression and antigenicity of c-terminal of GRP78.
Structure, function and regulation of the hsp90 machinery.
Structure, Function, and Regulation of the Hsp90 Machinery.
Structure-activity relationship of Garcinia xanthones analogues: Potent Hsp90 inhibitors with cytotoxicity and antiangiogenesis activity.
Structure-activity relationships in purine-based inhibitor binding to HSP90 isoforms.
Structure-Activity Relationships of Benzothiazole-Based Hsp90 C-Terminal-Domain Inhibitors.
Structure-based and in silico design of Hsp90 inhibitors.
Structure-based design, synthesis, and biological evaluation of Hsp90?-selective inhibitors.
Structure-based optimization of GRP78-binding peptides that enhances efficacy in cancer imaging and therapy.
Structure-guided cancer blockade between bioactive bursehernin and proteins: Molecular docking and molecular dynamics study.
Structure-guided design of an Hsp90? N-terminal isoform-selective inhibitor.
Study of single nucleotide polymorphisms of tumour necrosis factors and HSP genes in nasopharyngeal carcinoma in North East India.
Study on the anti-tumor efficacy induced by heat shock protein 70-peptide complexes derived from tumor cells.
Subcellular Hsp70 Inhibitors Promote Cancer Cell Death via Different Mechanisms.
Sublethal concentrations of 17-AAG suppress homologous recombination DNA repair and enhance sensitivity to carboplatin and olaparib in HR proficient ovarian cancer cells.
Submicroscopic deletion of 5q involving tumor suppressor genes (CTNNA1, HSPA9) and copy neutral loss of heterozygosity associated with TET2 and EZH2 mutations in a case of MDS with normal chromosome and FISH results.
Sulforaphane Potentiates the Efficacy of 17-Allylamino 17-Demethoxygeldanamycin Against Pancreatic Cancer Through Enhanced Abrogation of Hsp90 Chaperone Function.
Sulfoxythiocarbamate S-4 inhibits HSP90 in human cutaneous squamous cell carcinoma cells.
Sulphoxythiocarbamates modify cysteine residues in HSP90 causing degradation of client proteins and inhibition of cancer cell proliferation.
SUMOylation of HSP27 by small ubiquitin-like modifier 2/3 promotes proliferation and invasion of hepatocellular carcinoma cells.
Supplementation of Moringa oleifera leaf powder orally improved productive performance by enhancing the intestinal health in rabbits under chronic heat stress.
Supplementation of postbiotic RI11 improves antioxidant enzyme activity, upregulated gut barrier genes, and reduced cytokine, acute phase protein, and heat shock protein 70 gene expression levels in heat-stressed broilers.
Suppression of Heat Shock Protein 27 Using OGX-427 Induces Endoplasmic Reticulum Stress and Potentiates Heat Shock Protein 90 Inhibitors to Delay Castrate-resistant Prostate Cancer.
Suppression of heat shock protein 70 by siRNA enhances the antitumor effects of cisplatin in cultured human osteosarcoma cells.
Suppression of stress induction of the 78-kilodalton glucose regulated protein (GRP78) in cancer by IT-139, an anti-tumor ruthenium small molecule inhibitor.
Suppression of stress protein GRP78 induction in tumor B/C10ME eliminates resistance to cell mediated cytotoxicity.
Suppression of the transformed phenotype and induction of differentiation-like characteristics in cultured ovarian tumor cells by chronic treatment with progesterone.
Suppression of tumor necrosis factor receptor-associated protein 1 expression induces inhibition of cell proliferation and tumor growth in human esophageal cancer cells.
Surface charge and hydrophobicity determine ErbB2 binding to the Hsp90 chaperone complex.
Surface staining and cytotoxic activity of heat-shock protein 60 antibody in stressed aortic endothelial cells.
Survivin promoter-regulated oncolytic adenovirus with Hsp70 gene exerts effective antitumor efficacy in gastric cancer immunotherapy.
Survivin-Mediated Cancer Cell Migration Through GRP78 and Epithelial-Mesenchymal Transition (EMT) Marker Expression in Mahlavu Cells.
Sustained tumour eradication after induced caspase-3 activation and synchronous tumour apoptosis requires an intact host immune response.
SUV39H1 is a New Client Protein of Hsp90 Degradated by Chaetocin as a Novel C-Terminal Inhibitor of Hsp90.
Swe1Wee1-dependent tyrosine phosphorylation of Hsp90 regulates distinct facets of chaperone function.
Synergetic cytotoxic activity toward breast cancer cells enhanced by the combination of Antp-TPR hybrid peptide targeting Hsp90 and Hsp70-targeted peptide.
Synergistic action of the novel HSP90 inhibitor NVP-AUY922 with histone deacetylase inhibitors, melphalan, or doxorubicin in multiple myeloma.
Synergistic Activity of the HSP90 Inhibitor Ganetespib With Lapatinib Reverses Acquired Lapatinib Resistance in HER2-Positive Breast Cancer Cells.
Synergistic activity of the Hsp90 inhibitor ganetespib with taxanes in non-small cell lung cancer models.
Synergistic Antipancreatic Tumor Effect by Simultaneously Targeting Hypoxic Cancer Cells With HSP90 Inhibitor and Glycolysis Inhibitor.
Synergistic effects of geldanamycin and antitumor drugs.
Synergistic effects of heat and ET-18-OCH3 on membrane expression of hsp70 and lysis of leukemic K562 cells.
Synergistic effects of rmhTRAIL and 17-AAG on the proliferation and apoptosis of multiple myeloma cells.
Synergistic enhancement of cancer therapy using a combination of heat shock protein targeted HPMA copolymer-drug conjugates and gold nanorod induced hyperthermia.
Synergistic interaction of hyperthermia and gemcitabine in lung cancer.
Synergistic promotion of breast cancer cells death by targeting molecular chaperone GRP78 and heat shock protein 70.
Synergy of hypoxia relief and heat shock protein inhibition for phototherapy enhancement.
Syngeneic Murine Ovarian Cancer Model Reveals That Ascites Enriches for Ovarian Cancer Stem-Like Cells Expressing Membrane GRP78.
Synthesis and biological evaluation of 3,5-disubstituted-4-alkynylisoxozales as a novel class of HSP90 inhibitors.
Synthesis and biological evaluation of a new class of geldanamycin derivatives as potent inhibitors of Hsp90.
Synthesis and Biological Evaluation of Celastrol Derivatives with Improved Cytotoxic Selectivity and Antitumor Activities.
Synthesis and biological evaluation of coumarin replacements of novobiocin as Hsp90 inhibitors.
Synthesis and biological evaluation of geldanamycin analogs against human cancer cells.
Synthesis and Biological Evaluation of Novobiocin Core Analogues as Hsp90 Inhibitors.
Synthesis and evaluation of cell-permeable biotinylated PU-H71 derivatives as tumor Hsp90 probes.
Synthesis and Evaluation of the Tumor Cell Growth Inhibitory Potential of New Putative HSP90 Inhibitors.
Synthesis and in vitro antiproliferative activity of C5-benzyl substituted 2-amino-pyrrolo[2,3-d]pyrimidines as potent Hsp90 inhibitors.
Synthesis and Photophysical and Photocatalytic Properties of a Highly Fluorinated and Durable Phthalocyanine-Peptide Bioconjugate for Potential Theranostic Applications.
Synthesis and SAR study of N-(4-hydroxy-3-(2-hydroxynaphthalene-1-yl)phenyl)-arylsulfonamides: heat shock protein 90 (Hsp90) inhibitors with submicromolar activity in an in vitro assay.
Synthesis of 19-substituted geldanamycins with altered conformations and their binding to heat shock protein Hsp90.
Synthesis of a versatile metacyclophane macrolactam.
Synthesis of novel dual target inhibitors of PARP and HSP90 and their antitumor activities.
Synthesis of potential allosteric modulators of Hsp90 by chemical glycosylation of Eupomatenoid-6.
Synthesis of reblastatin, autolytimycin, and non-benzoquinone analogues: potent inhibitors of heat shock protein 90.
Synthesis, G-Quadruplex Stabilisation, Docking Studies, and Effect on Cancer Cells of Indolo[3,2-b]quinolines with One, Two, or Three Basic Side Chains.
Synthetic affibody molecules: a novel class of affinity ligands for molecular imaging of HER2-expressing malignant tumors.
Synthetic Antibody Mimics Based on Cancer-Targeting Immunostimulatory Peptides.
Synthetic approaches, anticancer potential, HSP90 inhibition, multitarget evaluation, molecular modeling and apoptosis mechanistic study of thioquinazolinone skeleton: Promising antibreast cancer agent.
Synthetic lethality of combined glutaminase and Hsp90 inhibition in mTORC1-driven tumor cells.
Synthetic small interfering RNA targeting heat shock protein 105 induces apoptosis of various cancer cells both in vitro and in vivo.
Synuclein ? protects Akt and mTOR and renders tumor resistance to Hsp90 disruption.
Synuclein gamma protects HER2 and renders resistance to Hsp90 disruption.
Systematic identification of the HSP90 regulated proteome.
Systemic Par-4 inhibits non-autochthonous tumor growth.
T cell activation by heat shock protein 70 vaccine requires TLR signaling and scavenger receptor expressed by endothelial cells-1.
Tanespimycin monotherapy in relapsed multiple myeloma: results of a phase 1 dose-escalation study.
Tanespimycin: the opportunities and challenges of targeting heat shock protein 90.
Targeted cancer therapy through 17-DMAG as an Hsp90 inhibitor: Overview and current state of the art.
Targeted delivery of chemotherapy using HSP90 inhibitor drug conjugates is highly active against pancreatic cancer models.
Targeted delivery of heat shock protein 90 inhibitors prevents growth of HER2-positive tumor.
Targeted hyperthermia using magnetite cationic liposomes and an alternating magnetic field in a mouse osteosarcoma model.
Targeted inhibition of GRP78 by HA15 promotes apoptosis of lung cancer cells accompanied by ER stress and autophagy.
Targeted Inhibition of Heat Shock Protein 90 Suppresses Tumor Necrosis Factor-? and Ameliorates Murine Intestinal Inflammation.
Targeted inhibition of Hsp90 by ganetespib is effective across a broad spectrum of breast cancer subtypes.
Targeted inhibition of mitochondrial Hsp90 suppresses localised and metastatic prostate cancer growth in a genetic mouse model of disease.
Targeted molecular-genetic imaging and ligand-directed therapy in aggressive variant prostate cancer.
Targeted mutation of the mouse Grp94 gene disrupts development and perturbs endoplasmic reticulum stress signaling.
Targeted near infrared hyperthermia combined with immune stimulation for optimized therapeutic efficacy in thyroid cancer treatment.
Targeted therapies with chemoradiation in esophageal cancer: development and future directions.
Targeted therapy of gastroenteropancreatic neuroendocrine tumours: preclinical strategies and future targets.
Targeted-delivery of siRNA via a polypeptide-modified liposome for the treatment of gp96 over-expressed breast cancer.
Targeting Aerobic Glycolysis and HIF-1alpha Expression Enhance Imiquimod-induced Apoptosis in Cancer Cells.
Targeting Cancer Metabolism Breaks Radioresistance by Impairing the Stress Response.
Targeting Cdc37 inhibits multiple signaling pathways and induces growth arrest in prostate cancer cells.
Targeting CDC37: an alternative, kinase-directed strategy for disruption of oncogenic chaperoning.
Targeting chaperones in transformed systems--a focus on Hsp90 and cancer.
Targeting CK2-driven non-oncogene addiction in B-cell tumors.
Targeting conserved water molecules: design of 4-aryl-5-cyanopyrrolo[2,3-d]pyrimidine Hsp90 inhibitors using fragment-based screening and structure-based optimization.
Targeting focal adhesion kinase with dominant-negative FRNK or Hsp90 inhibitor 17-DMAG suppresses tumor growth and metastasis of SiHa cervical xenografts.
Targeting gene expression to tumor cells with loss of wild-type p53 function.
Targeting GRP75 improves HSP90 inhibitor efficacy by enhancing p53-mediated apoptosis in hepatocellular carcinoma.
Targeting GRP78 enhances the sensitivity of HOS osteosarcoma cells to pyropheophorbide-? methyl ester-mediated photodynamic therapy via the Wnt/?-catenin signaling pathway.
Targeting heat shock protein 27 (HspB1) interferes with bone metastasis and tumour formation in vivo.
Targeting Heat Shock Protein 27 in Cancer: A Druggable Target for Cancer Treatment?
Targeting heat shock protein 70 using gold nanorods enhances cancer cell apoptosis in low dose plasmonic photothermal therapy.
Targeting heat shock protein 90 for anti-cancer drug development.
Targeting Heat Shock Protein 90 in Pancreatic Cancer Impairs Insulin-like Growth Factor-I Receptor Signaling, Disrupts an Interleukin-6/Signal-Transducer and Activator of Transcription 3/Hypoxia-Inducible Factor-1{alpha} Autocrine Loop, and Reduces Orthotopic Tumor Growth.
Targeting heat shock protein 90 induces apoptosis and inhibits critical survival and proliferation pathways in multiple myeloma.
Targeting heat shock protein 90 with non-quinone inhibitors: A novel chemotherapeutic approach in human hepatocellular carcinoma.
Targeting Heat Shock Proteins 60 and 70 of Toxoplasma gondii as a Potential Drug Target: In Silico Approach.
Targeting Heat Shock Proteins 70/90 and Proteasome for Cancer Therap.
Targeting heat shock proteins in cancer.
Targeting Heat Shock Proteins in Cancer: A Promising Therapeutic Approach.
Targeting heat shock proteins on cancer cells: selection, characterization, and cell-penetrating properties of a peptidic GRP78 ligand.
Targeting heat shock response to sensitize cancer cells to proteasome and Hsp90 inhibitors.
Targeting Heat-Shock Protein 90 (HSP90) as a Complementary Strategy to Immune Checkpoint Blockade for Cancer Therapy.
Targeting heat-shock protein 90 improves efficacy of rapamycin in a model of hepatocellular carcinoma in mice.
Targeting heat-shock protein 90 with ganetespib for molecularly targeted therapy of gastric cancer.
Targeting heat-shock-protein 90 (Hsp90) by natural products: geldanamycin, a show case in cancer therapy.
Targeting highly expressed extracellular HSP90 in breast cancer stem cells inhibits tumor growth in vitro and in vivo.
Targeting HSF1 disrupts HSP90 chaperone function in chronic lymphocytic leukemia.
Targeting HSF1 sensitizes cancer cells to HSP90 inhibition.
Targeting HSP90 by the novel inhibitor NVP-AUY922 reduces growth and angiogenesis of pancreatic cancer.
Targeting hsp90 family members: A strategy to improve cancer cell death.
Targeting HSP90 for cancer therapy.
Targeting Hsp90 for the treatment of cancer.
Targeting Hsp90 in Non-Cancerous Maladies.
Targeting Hsp90 in urothelial carcinoma.
Targeting Hsp90 with small molecule inhibitors induces the over-expression of the anti-apoptotic molecule, survivin, in human A549, HONE-1 and HT-29 cancer cells.
Targeting HSP90 with the small molecule inhibitor AUY922 (luminespib) as a treatment strategy against hepatocellular carcinoma.
Targeting Hsp90: small-molecule inhibitors and their clinical development.
Targeting HSPA8 inhibits proliferation via downregulating BCR-ABL and enhances chemosensitivity in imatinib-resistant chronic myeloid leukemia cells.
Targeting KRAS-mutant non-small cell lung cancer with the Hsp90 inhibitor ganetespib.
Targeting membrane heat-shock protein 70 (Hsp70) on tumors by cmHsp70.1 antibody.
Targeting mitochondrial biogenesis to overcome drug resistance to MAPK inhibitors.
Targeting Mortalin by Embelin Causes Activation of Tumor Suppressor p53 and Deactivation of Metastatic Signaling in Human Breast Cancer Cells.
Targeting mortalin using conventional and RNA-helicase-coupled hammerhead ribozymes.
Targeting multiple signal transduction pathways through inhibition of Hsp90.
Targeting of DNA Damage Signaling Pathway Induced Senescence and Reduced Migration of Cancer cells.
Targeting of KRAS mutant tumors by HSP90 inhibitors involves degradation of STK33.
Targeting of multiple oncogenic signaling pathways by Hsp90 inhibitor alone or in combination with berberine for treatment of colorectal cancer.
Targeting of multiple signalling pathways by heat shock protein 90 molecular chaperone inhibitors.
Targeting oral cancer stemness and chemoresistance by isoliquiritigenin-mediated GRP78 regulation.
Targeting PI3K/Akt/HSP90 Signaling Sensitizes Gastric Cancer Cells to Deoxycholate-Induced Apoptosis.
Targeting plasma membrane GRP78 for cancer growth inhibition.
Targeting solid tumors via T cell receptor complementarity-determining region 3delta in an engineered antibody.
Targeting survivin in cancer: the cell-signalling perspective.
Targeting the Diabetic Chaperome to Improve Peripheral Neuropathy.
Targeting the dynamic HSP90 complex in cancer.
Targeting the entry region of Hsp90's ATP binding pocket with a novel 6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl amide.
Targeting the Extracellular HSP90 Co-Chaperone Morgana Inhibits Cancer Cell Migration and Promotes Anticancer Immunity.
Targeting the glucose-regulated protein-78 abrogates Pten-null driven AKT activation and endometrioid tumorigenesis.
Targeting the GRP78 Pathway for Cancer Therapy.
Targeting the heat shock protein 90: a rational way to inhibit macrophage migration inhibitory factor function in cancer.
Targeting the Hsp90 C-terminal domain to induce allosteric inhibition and selective client downregulation.
Targeting the Hsp90 chaperone: synthesis of novel resorcylic acid macrolactone inhibitors of Hsp90.
Targeting the Hsp90 molecular chaperone with novel macrolactams. Synthesis, structural, binding, and cellular studies.
Targeting the Hsp90-associated viral oncoproteome in gammaherpesvirus-associated malignancies.
Targeting the HSP90-CDC37-kinase chaperone cycle: A promising therapeutic strategy for cancer.
Targeting the molecular chaperone heat shock protein 90 (HSP90): Lessons learned and future directions.
Targeting the molecular chaperone heat shock protein 90 provides a multifaceted effect on diverse cell signaling pathways of cancer cells.
Targeting the MYC Oncogene in Burkitt Lymphoma through HSP90 Inhibition.
Targeting the unfolded protein response in cancer therapy.
Targeting the unfolded protein response in glioblastoma cells with the fusion protein EGF-SubA.
Targeting to overexpressed glucose-regulated protein 78 in gastric cancer discovered by 2D DIGE improves the diagnostic and therapeutic efficacy of micelles-mediated system.
Targeting tumour-supportive cellular machineries in anticancer drug development.
Targeting wide-range oncogenic transformation via PU24FCl, a specific inhibitor of tumor Hsp90.
TAS-116, a highly selective inhibitor of heat shock protein 90? and ?, demonstrates potent antitumor activity and minimal ocular toxicity in preclinical models.
TAS-116, a Novel Hsp90 Inhibitor, Selectively Enhances Radiosensitivity of Human Cancer Cells to X-rays and Carbon Ion Radiation.
TAT-mediated gp96 transduction to APCs enhances gp96-induced antiviral and antitumor T cell responses.
Technology evaluation: HSPPC-96, antigenics.
Telomerase promotes formation of a telomere protective complex in cancer cells.
Temsirolimus, an mTOR inhibitor, enhances anti-tumour effects of heat shock protein cancer vaccines.
Tephrosin-induced autophagic cell death in A549 non-small cell lung cancer cells.
Testicular superoxide dismutase activity, heat shock protein 70 concentration and blood plasma inhibin-alpha concentration of dogs with a Sertoli cell tumor in a unilateral cryptorchid testis.
Testis cancer.
Th1 cytokine interferon gamma improves response in HER2 breast cancer by modulating the ubiquitin proteasomal pathway.
The 'peptidome' of tumour-derived chaperone-rich cell lysate anti-cancer vaccines reveals potential tumour antigens that stimulate tumour immunity.
The 4C5 cell-impermeable anti-HSP90 antibody with anti-cancer activity, is composed of a single light chain dimer.
The 60-kDa heat shock protein regulates energy rearrangement and protein synthesis to promote proliferation of multiple myeloma cells.
The 8.1 ancestral MHC haplotype is associated with delayed onset of colonization in cystic fibrosis.
The achilles heel of ErbB-2/HER2: regulation by the Hsp90 chaperone machine and potential for pharmacological intervention.
The adenovirus E1B 19-kilodalton protein stimulates gene expression by increasing DNA levels.
The Ameliorative Effects of Ascorbic Acid on Critical Illness Polyneuropathy in Rodent Sepsis Model.
The analysis of chemotherapy resistance in human lung cancer cell line with microchip-based system.
The Antagonistic Effect of Selenium on Lead-Induced Inflammatory Factors and Heat Shock Protein mRNA Level in Chicken Cartilage Tissue.
The Antagonistic Effect of Selenium on Lead-Induced Inflammatory Factors and Heat Shock Proteins mRNA Expression in Chicken Livers.
The anti-cancer drug cisplatin induces H25 in Ehrlich ascites tumor cells by a mechanism different from transcriptional stimulation influencing predominantly H25 translation.
The anti-cancer IgM monoclonal antibody PAT-SM6 binds with high avidity to the unfolded protein response regulator GRP78.
The Anti-Inflammatory Effects of the Small Molecule Pifithrin-µ on BV2 Microglia.
The anticancer drug AUY922 generates a proteomics fingerprint that is highly conserved among structurally diverse Hsp90 inhibitors.
The Application of the in-Situ Hyperthermia Emission from Acoustic Nanodroplets for Theranostic Dual-Imaging and Antitumor Modalities.
The Association Between HSP90/topoisomerase I Immunophenotype and the Clinical Features of Colorectal Cancers in Respect to KRAS Gene Status.
The association of elevated reactive oxygen species levels from neutrophils with low-grade inflammation in the elderly.
The ATAD2/ANCCA homolog Yta7 cooperates with Scm3HJURP to deposit Cse4CENP-A at the centromere in yeast.
The BAX/BAK-like protein BOK is a prognostic marker in colorectal cancer.
The benzoquinone ansamycin 17-allylamino-17-demethoxygeldanamycin binds to HSP90 and shares important biologic activities with geldanamycin.
The C-terminal half of heat shock protein 90 represents a second site for pharmacologic intervention in chaperone function.
The cell surface GRP78 facilitates the invasion of hepatocellular carcinoma cells.
The chaperone Hsp70 is a BH3 receptor activated by the pro-apoptotic Bim to stabilize anti-apoptotic clients.
The Chaperone TRAP1 As a Modulator of the Mitochondrial Adaptations in Cancer Cells.
The chaperone-associated ubiquitin ligase CHIP is able to target p53 for proteasomal degradation.
The chronic spleen injury of mice following long-term exposure to titanium dioxide nanoparticles.
The clinical applications of heat shock protein inhibitors in cancer - present and future.
The Clinical Value of HSP60 in Digestive System Cancers: a Systematic Review and Meta-Analysis.
The clinicopathological significance of Mortalin overexpression in invasive ductal carcinoma of breast.
The co-chaperone p23 is degraded by caspases and the proteasome during apoptosis.
The co-chaperone UNC45A is essential for the expression of mitotic kinase NEK7 and tumorigenesis.
The combination of Hsp90 inhibitor 17AAG and heavy-ion irradiation provides effective tumor control in human lung cancer cells.
The complementation of yeast with human or Plasmodium falciparum Hsp90 confers differential inhibitor sensitivities.
The complex function of hsp70 in metastatic cancer.
The conformation-specific Hsp90 inhibition interferes with the oncogenic RAF kinase adaptation and triggers premature cellular senescence, hence, acts as a tumor suppressor mechanism.
The critical role of GRP78 in physiologic and pathologic stress.
The DAC system and associations with multiple myeloma.
The deubiquitylase USP2 maintains ErbB2 abundance via counteracting endocytic degradation and represents a therapeutic target in ErbB2-positive breast cancer.
The Development of Hsp90?-Selective Inhibitors to Overcome Detriments Associated with pan-Hsp90 Inhibition.
The dietary bioflavonoid, quercetin, selectively induces apoptosis of prostate cancer cells by down-regulating the expression of heat shock protein 90.
The disruption of protein-protein interactions with co-chaperones and client substrates as a strategy towards Hsp90 inhibition.
The dissociation of the Hsp60/pro-Caspase-3 complex by bis(pyridyl)oxadiazole copper complex (CubipyOXA) leads to cell death in NCI-H292 cancer cells.
The double edge of the HSP90-CDC37 chaperone machinery: opposing determinants of kinase stability and activity.
The double-edged sword: conserved functions of extracellular hsp90 in wound healing and cancer.
The driver of malignancy in KG-1a leukemic cells, FGFR1OP2-FGFR1, encodes an HSP90 addicted oncoprotein.
The effect of celastrol, a triterpene with antitumorigenic activity, on conformational and functional aspects of the human 90kDa heat shock protein Hsp90?, a chaperone implicated in the stabilization of the tumor phenotype.
The effect of cisplatin, etoposide and quercetin on Hsp72 expression.
The Effect of Continuous Sedation Therapy on Immunomodulation, Plasma Levels of Antioxidants, and Indicators of Tissue Repair in Post-Burn Sepsis Patients.
The Effect of Heat Shock Protein 90 Inhibitor on Pain in Cancer Patients: A Systematic Review and Meta-Analysis.
The effect of heat shock protein 90 inhibitors on histone 4 lysine 20 methylation in bladder cancer.
The effect of heat shock, cisplatin, etoposide and quercetin on Hsp27 expression in human normal and tumour cells.
The effect of quercetin on apoptosis and necrosis induction in human colon adenocarcinoma cell line LS180.
The effect of simvastatin on the proteome of detergent-resistant membrane domains: Decreases of specific proteins previously related to cytoskeleton regulation, calcium homeostasis and cell fate.
The effect of vaccination with the lysate of heat-shocked tumor cells on nitric oxide production in BALB/c mice with fibrosarcoma tumor.
The effect of Zhangfei on the unfolded protein response and growth of cells derived from canine and human osteosarcomas.
The effects inhibiting the proliferation of cancer cells by far-infrared radiation (FIR) are controlled by the basal expression level of heat shock protein (HSP) 70A.
The effects of Ficus carica polysaccharide on immune response and expression of some immune-related genes in grass carp, Ctenopharyngodon idella.
The effects of Hsp90 expression alteration on spinal metastases of breast carcinoma.
The effects of KNK437, a novel inhibitor of heat shock protein synthesis, on the acquisition of thermotolerance in a murine transplantable tumor in vivo.
The Effects of Mouse Recombinant Resistin on mRNA Expression of Proinflammatory and Anti-Inflammatory Cytokines and Heat Shock Protein-70 in Experimental Stroke Model.
The effects of Natucin C-Natucin P mixture on blood biochemical parameters, antioxidant activity and non-specific immune responses in tilapia (Oreochromis niloticus).
The Endogenous GRP78 Interactome in Human Head and Neck Cancers: A Deterministic Role of Cell Surface GRP78 in Cancer Stemness.
The Endoplasmic Reticulum Chaperone GRP170: From Immunobiology to Cancer Therapeutics.
The endoplasmic reticulum stress markers GRP78 and CHOP predict disease-free survival and responsiveness to chemotherapy in breast cancer.
The Escherichia coli Subtilase Cytotoxin A Subunit Specifically Cleaves Cell-Surface GRP78 and Abolishes COOH-Terminal-Dependent Signaling.
The estrogen-inducible transferrin receptor-like membrane glycoprotein is related to stress-regulated proteins.
The expanding proteome of the molecular chaperone HSP90.
The expression of HSP60 and HSP10 in large bowel carcinomas with lymph node metastase.
The expression of HSP70 and HSP90alpha in children with Wilms tumor.
The expression of mycobacterial heat shock protein (HSP64) on Meth A tumour cells.
The expression of the molecular chaperone calnexin is decreased in cancer cells grown as colonies compared to monolayer.
The expression profiles and prognostic values of HSP70s in hepatocellular carcinoma.
The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and enhance drug binding.
The fungal Achilles' heel: targeting Hsp90 to cripple fungal pathogens.
The G?-interacting vesicle-associated protein interacts with and promotes cell surface localization of GRP78 during endoplasmic reticulum stress.
The geldanamycin analogue 17-allylamino-17-demethoxygeldanamycin inhibits the growth of GL261 glioma cells in vitro and in vivo.
The GroEL protein of Porphyromonas gingivalis accelerates tumor growth by enhancing endothelial progenitor cell function and neovascularization.
The heat shock protein 47 as a potential biomarker and a therapeutic agent in cancer research.
The heat shock protein 90 chaperone complex: an evolving therapeutic target.
The heat shock protein 90 inhibitor IPI-504 induces apoptosis of AKT-dependent diffuse large B-cell lymphomas.
The heat shock protein 90 inhibitor IPI-504 induces KIT degradation, tumor shrinkage and cell proliferation arrest in xenografts models of gastrointestinal stromal tumors.
The heat shock protein 90 inhibitor, (-)-epigallocatechin gallate, has anticancer activity in a novel human prostate cancer progression model.
The heat shock protein 90 inhibitor, 17-allylamino-17-demethoxygeldanamycin, enhances osteoclast formation and potentiates bone metastasis of a human breast cancer cell line.
The heat shock protein 90 inhibitor, AT13387, displays a long duration of action in vitro and in vivo in non-small cell lung cancer.
The heat shock protein 90-binding geldanamycin inhibits cancer cell proliferation, down-regulates oncoproteins, and inhibits epidermal growth factor-induced invasion in thyroid cancer cell lines.
The heat shock protein HSP70 promotes mouse NK cell activity against tumors that express inducible NKG2D ligands.
The heat shock transcription factor 1 as a potential new therapeutic target in multiple myeloma.
The hERG channel is dependent upon the Hsp90? isoform for maturation and trafficking.
The hexameric structures of human heat shock protein 90.
The histone deacetylase inhibitor SAHA induces HSP60 nitration and its extracellular release by exosomal vesicles in human lung-derived carcinoma cells.
The Hsp70 inhibiting peptide aptamer A17 potentiates radiosensitization of tumor cells by Hsp90 inhibition.
The HSP90 and DNA topoisomerase VI inhibitor radicicol also inhibits human type II DNA topoisomerase.
The Hsp90 chaperone complex A potential target for cancer therapy?
The Hsp90 chaperone complex as a novel target for cancer therapy.
The HSP90 chaperone machinery.
The Hsp90 chaperone machinery: from structure to drug development.
The Hsp90 Co-chaperones Sti1, Aha1, and P23 Regulate Adaptive Responses to Antifungal Azoles.
The HSP90 Family: Structure, Regulation, Function, and Implications in Health and Disease.
The HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin modulates radiosensitivity by downregulating serine/threonine kinase 38 via Sp1 inhibition.
The HSP90 inhibitor 17-N-allylamino-17-demethoxy geldanamycin (17-AAG) synergizes with cisplatin and induces apoptosis in cisplatin-resistant esophageal squamous cell carcinoma cell lines via the Akt/XIAP pathway.
The HSP90 inhibitor ganetespib has chemosensitizer and radiosensitizer activity in colorectal cancer.
The HSP90 inhibitor ganetespib synergizes with the MET kinase inhibitor crizotinib in both crizotinib-sensitive and -resistant MET-driven tumor models.
The HSP90 inhibitor ganetespib: A potential effective agent for Acute Myeloid Leukemia in combination with cytarabine.
The Hsp90 inhibitor IPI-504 rapidly lowers EML4-ALK levels and induces tumor regression in ALK-driven NSCLC models.
The Hsp90 inhibitor NVP-AUY922-AG inhibits NF-?B signaling, overcomes microenvironmental cytoprotection and is highly synergistic with fludarabine in primary CLL cells.
The HSP90 inhibitor NVP-AUY922-AG inhibits the PI3K and IKK signalling pathways and synergizes with cytarabine in acute myeloid leukaemia cells.
The HSP90 inhibitor Onalespib exerts synergistic anti-cancer effects when combined with radiotherapy: an in vitro and in vivo approach.
The Hsp90 inhibitor SNX-2112, induces apoptosis in multidrug resistant K562/ADR cells through suppression of Akt/NF-?B and disruption of mitochondria-dependent pathways.
The HSP90 Inhibitor, AT13387, Is Effective against Imatinib-Sensitive and -Resistant Gastrointestinal Stromal Tumor Models.
The HSP90 molecular chaperone - an enigmatic ATPase.
The Hsp90 molecular chaperone: an open and shut case for treatment.
The human immunodeficiency virus protease inhibitor ritonavir is potentially active against urological malignancies.
The Ig VH complementarity-determining region 3-containing Rb9 peptide, inhibits melanoma cells migration and invasion by interactions with Hsp90 and an adhesion G-protein coupled receptor.
The immunological era in melanoma treatment: new challenges for heat shock protein-based vaccine in the advanced disease.
The increase in the frequency of MICA gene A6 allele in oral squamous cell carcinoma.
The induction of heme oxygenase-1 suppresses heat shock protein 90 and the proliferation of human breast cancer cells through its byproduct carbon monoxide.
The influence of liposomal quercetin on liver damage induced by microwave ablation.
The interaction of HspA1A with TLR2 and TLR4 in the response of neutrophils induced by ovarian cancer cells in vitro.
The Involvement of Danger-Associated Molecular Patterns in the Development of Immunoparalysis in Cardiac Arrest Patients.
The J domain of simian virus 40 large T antigen is required to functionally inactivate RB family proteins.
The matrix metalloproteinase 7 (MMP7) links Hsp90 chaperone with acquired drug resistance and tumor metastasis.
The mitochondrial chaperone Prohibitin 1 negatively regulates interleukin-8 in human liver cancers.
The mitochondrial chaperone protein TRAP1 mitigates ?-Synuclein toxicity.
The Mitochondrial Chaperone TRAP1 as a Candidate Target of Oncotherapy.
The mitochondrial chaperone TRAP1 promotes neoplastic growth by inhibiting succinate dehydrogenase.
The Mitochondrial Hsp90 TRAP1 and Alzheimer's Disease.
The modulation of protein kinase A and heat shock protein 70 is involved in the reversible increase of blood-brain tumor barrier permeability induced by papaverine.
The Molecular Chaperone GRP78/BiP in the Development of Chemoresistance: Mechanism and Possible Treatment.
The molecular chaperone TRAP1 in cancer: From the basics of biology to pharmacological targeting.
The Natural Compound Cantharidin Induces Cancer Cell Death through Inhibition of Heat Shock Protein 70 (HSP70) and Bcl-2-associated Athanogene Domain 3 (BAG3) Expression by Blocking Heat Shock Factor 1 (HSF1) Binding to Promoters.
The Natural Compound Oblongifolin C Exhibits Anticancer Activity by Inhibiting HSPA8 and Cathepsin B In Vitro.
The natural human IgM antibody PAT-SM6 induces apoptosis in primary human multiple myeloma cells by targeting heat shock protein GRP78.
The network interaction of the human cytosolic 90kDa heat shock protein Hsp90: A target for cancer therapeutics.
The neuroblastoma tumour-suppressor TrkAI and its oncogenic alternative TrkAIII splice variant exhibit geldanamycin-sensitive interactions with Hsp90 in human neuroblastoma cells.
The new platinum(IV) derivative LA-12 shows stronger inhibitory effect on Hsp90 function compared to cisplatin.
The next generation of peptide receptor radionuclide therapy.
The Noncompetitive Effect of Gambogic Acid Displaces Fluorescence-Labeled ATP but Requires ATP for Binding to Hsp90/HtpG.
The novel HSP90 inhibitor AT13387 potentiates radiation effects in squamous cell carcinoma and adenocarcinoma cells.
The novel Hsp90 inhibitor NXD30001 induces tumor regression in a genetically engineered mouse model of glioblastoma multiforme.
The novel HSP90 inhibitor STA-9090 exhibits activity against Kit-dependent and -independent malignant mast cell tumors.
The Novel HSP90 Inhibitor, IPI-493, Is Highly Effective in Human Gastrostrointestinal Stromal Tumor Xenografts Carrying Heterogeneous KIT Mutations.
The Novel Oral Hsp90 Inhibitor NVP-HSP990 Exhibits Potent and Broad-spectrum Antitumor Activities In Vitro and In Vivo.
The odyssey of hsp60 from tumor cells to other destinations includes plasma membrane-associated stages and Golgi and exosomal protein-trafficking modalities.
The opportunities and challenges of personalized genome-based molecular therapies for cancer: targets, technologies, and molecular chaperones.
The Par-4-GRP78 TRAIL, more twists and turns.
The physiological performance and immune response of juvenile turbot (Scophthalmus maximus) to nitrite exposure.
The plant diterpene epoxysiderol targets Hsp70 in cancer cells, affecting its ATPase activity and reducing its translocation to plasma membrane.
The platelet-derived growth factor receptor alpha is destabilized by geldanamycins in cancer cells.
The presence of anti-GRP78 antibodies in the serum of patients with colorectal carcinoma: a potential biomarker for early cancer detection.
The protective role of selenium against cadmium-induced hepatotoxicity in laying hens: Expression of Hsps and inflammation-related genes and modulation of elements homeostasis.
The purine scaffold Hsp90 inhibitor PU-H71 sensitizes cancer cells to heavy ion radiation by inhibiting DNA repair by homologous recombination and non-homologous end joining.
The rapid and direct determination of ATPase activity by ion exchange chromatography and the application to the activity of heat shock protein-90.
The rat 78,000 dalton glucose-regulated protein (GRP78) as a precursor for the rat steroidogenesis-activator polypeptide (SAP): the SAP coding sequence is homologous with the terminal end of GRP78.
The reaction of posttransplant denervated liver on the hemorrhagic shock in rats.
The regulatory mechanism of Hsp90alpha secretion and its function in tumor malignancy.
The regulatory mechanism of Hsp90alpha secretion from endothelial cells and its role in angiogenesis during wound healing.
The relationship between three heat shock protein 70 gene polymorphisms and susceptibility to lung cancer.
The Relationship of Immunoexpression of Ki-67 and Hsp70 with Clinical and Morphological Parameters and Prognosis of Papillary Thyroid Cancer.
The release of Hsp70 from A431 carcinoma cells is mediated by secretory-like granules.
The Right Tool for the Job: An Overview of Hsp90 Inhibitors.
The role of c-Src in the invasion and metastasis of hepatocellular carcinoma cells induced by association of cell surface GRP78 with activated ?2M.
The role of calreticulin mutations in myeloproliferative neoplasms.
The role of ferroptosis in digestive system cancer.
The role of functional and molecular imaging in cancer drug discovery and development.
The role of heat shock protein 90 in the regulation of tumor cell apoptosis.
The role of heat shock proteins in cancer.
The Role of Heat Shock Proteins in Leukemia.
The Role of Heat Shock Proteins in Regulating Receptor Signal Transduction.
The role of HSP90 in Quercetin-induced apoptosis in human papillary thyroid (B-CPAP) cancer cells.
The role of HSP90 molecular chaperones in hepatocellular carcinoma.
The role of N6-methyladenosine RNA methylation in the heat stress response of sheep (Ovis aries).
The Role of p38 and CK2 Protein Kinases in the Response of RAW 264.7 Macrophages to Lipopolysaccharide.
The role of the molecular chaperone CCT in protein folding and mediation of cytoskeleton-associated processes: implications for cancer cell biology.
The selective Hsp90 inhibitor BJ-B11 exhibits potent antitumor activity via induction of cell cycle arrest, apoptosis and autophagy in Eca-109 human esophageal squamous carcinoma cells.
The sensitivity to Hsp90 inhibitors of both normal and oncogenically transformed cells is determined by the equilibrium between cellular quiescence and activity.
The short-term effects of electrosurgical ablation on proinflammatory mediator production by intervertebral disc cells in tissue culture.
The small heat shock protein alpha B-crystallin is a novel inhibitor of TRAIL-induced apoptosis that suppresses the activation of caspase-3.
The small heat shock protein HspB2 is a novel anti-apoptotic protein that inhibits apical caspase activation in the extrinsic apoptotic pathway.
The small-molecule kinase inhibitor D11 counteracts 17-AAG-mediated up-regulation of HSP70 in brain cancer cells.
The spectral properties of (-)-epigallocatechin 3-O-gallate (EGCG) fluorescence in different solvents: dependence on solvent polarity.
The stress response: implications for the clinical development of hsp90 inhibitors.
The targeted inhibition of Hsp90 by a synthetic small molecule, DPide offers an effective treatment strategy against TNBCs.
The therapeutic implications of clinically applied modifiers of heat shock protein 70 (Hsp70) expression by tumor cells.
The therapeutic properties of resminostat for hepatocellular carcinoma.
The Therapeutic Target Hsp90 and Cancer Hallmarks.
The transcriptional factor YY1 upregulates the novel invasion suppressor HLJ1 expression and inhibits cancer cell invasion.
The transcriptomic responses of the ark shell, Anadara broughtonii, to sulfide and hypoxia exposure.
The treatment and prevention of mouse melanoma with an oral DNA vaccine carried by attenuated Salmonella typhimurium.
The tumor promoting roles of HSP60 and HIF2? in gastric cancer cells.
The tumor suppressor Par-4 activates an extrinsic pathway for apoptosis.
The unfolded protein response regulator GRP78 is a novel predictive biomarker in colorectal cancer.
The universe of Hsp90.
The ups and downs of MEK kinase interactions.
The use of hybrid phage displaying antigen epitope and recombinant protein in the diagnosis of systemic Candida albicans infection in rabbits and cancer patients.
The use of matrix coating assisted by an electric field (MCAEF) to enhance mass spectrometric imaging of human prostate cancer biomarkers.
The versatile stress protein mortalin as a chaperone therapeutic agent.
Therapeutic Ablation of Gain-of-Function Mutant p53 in Colorectal Cancer Inhibits Stat3-Mediated Tumor Growth and Invasion.
Therapeutic and diagnostic implications of Hsp90 activation.
Therapeutic cancer vaccines.
Therapeutic effects of kaempferol affecting autophagy and endoplasmic reticulum stress.
Therapeutic effects of radiolabeled 17-allylamino-17-demethoxygeldanamycin on human H460 nonsmall-cell lung carcinoma xenografts in mice.
Therapeutic efficacy of tumor-derived heat shock protein 70 immunotherapy combining interleukin-2 on tumor-bearing mice.
Therapeutic option for managing lung injury induced by infrarenal aortic cross-clamping.
Therapeutic potency of heat-shock protein-90 pharmacological inhibitors in the treatment of gastrointestinal cancer, current status and perspectives.
Therapeutic strategies to overcome crizotinib resistance in non-small cell lung cancers harboring the fusion oncogene EML4-ALK.
Therapeutic targeting of BET bromodomain protein, Brd4, delays cyst growth in ADPKD.
Therapeutic uses of HSP90 inhibitors in Non-Small Cell Lung Carcinoma (NSCLC).
Thermal aggregates of human mortalin and Hsp70-1A behave as supramolecular assemblies.
Thermally Responsive Nanoparticle-Encapsulated Curcumin and Its Combination with Mild Hyperthermia for Enhanced Cancer Cell Destruction.
Thermosensitization, heat shock protein synthesis and development of thermotolerance in M-14 human tumor cells subjected to step-down heating.
Thermotherapy using magnetic cationic liposomes powerfully suppresses prostate cancer bone metastasis in a novel rat model.
Threonine modulates immune response, antioxidant status and gene expressions of antioxidant enzymes and antioxidant-immune-cytokine-related signaling molecules in juvenile blunt snout bream (Megalobrama amblycephala).
Tid1, a cochaperone of the heat shock 70 protein and the mammalian counterpart of the Drosophila tumor suppressor l(2)tid, is critical for early embryonic development and cell survival.
Time-of-day specificity of anticancer drugs may be mediated by circadian regulation of the cell cycle.
TNF induced cleavage of HSP90 by cathepsin D potentiates apoptotic cell death.
TNF-alpha, IL-1 alpha, IL-6 and ICAM-1 expression in human keratinocytes stimulated in vitro with Escherichia coli heat-shock proteins.
To fold or not to fold: modulation and consequences of Hsp90 inhibition.
Tomm34 is commonly expressed in epithelial ovarian cancer and associates with tumour type and high FIGO stage.
Tosylcyclonovobiocic acids promote cleavage of the hsp90-associated cochaperone p23.
Total flavonoids, extracted from Polygonum knotweed L, exert beneficial hepatoprotection against liver injury.
Total synthesis of herbimycin A.
Towards a better way to die with chemotherapy: role of heat shock protein exposure on dying tumor cells.
Towards a transcriptome-based theranostic platform for unfavorable breast cancer phenotypes.
Towards in-silico design of new HSP90 inhibitors: Molecular docking and 3D-QSAR CoMFA studies of tetrahydropyrido [4, 3-d] pyrimidine derivatives as HSP90 inhibitors.
Traditional and Novel Mechanisms of Heat Shock Protein 90 (HSP90) Inhibition in Cancer Chemotherapy Including HSP90 Cleavage.
Transactivation of the epidermal growth factor receptor by heat shock protein 90 via Toll-like receptor 4 contributes to the migration of glioblastoma cells.
Transcatheter arterial embolization combined with radiofrequency ablation activates CD8(+) T-cell infiltration surrounding residual tumors in the rabbit VX2 liver tumors.
Transcription inhibition of heat shock proteins: a strategy for combination of 17-allylamino-17-demethoxygeldanamycin and actinomycin d.
Transcriptional activation of heat shock protein 27 gene expression by 17beta-estradiol and modulation by antiestrogens and aryl hydrocarbon receptor agonists.
Transcriptional induction of GRP78/BiP by histone deacetylase inhibitors and resistance to histone deacetylase inhibitor-induced apoptosis.
Transcriptional regulation of small HSP-HSF1 and beyond.
Transcriptional upregulation of HSP70-2 by HIF-1 in cancer cells in response to hypoxia.
Transcriptome analysis of human Leydig cell tumours reveals potential mechanisms underlying its development.
Transcriptomic analysis of the effect of ifosfamide on MDCK cells cultivated in microfluidic biochips.
Transcriptomic analysis reveals that heat shock protein 90? is a potential diagnostic and prognostic biomarker for cancer.
Transcriptomic and proteomic approach to studying SNX-2112-induced K562 cells apoptosis and anti-leukemia activity in K562-NOD/SCID mice.
Transcriptomic and Proteomic Investigation of HSP90A as a Potential Biomarker for HCC.
Transcriptomic characterization of fibrolamellar hepatocellular carcinoma.
Transformation of the Non-Selective Aminocyclohexanol-Based Hsp90 Inhibitor into a Grp94-Seletive Scaffold.
Translational control in the stress adaptive response of cancer cells: a novel role for the heat shock protein TRAP1.
Translational Research to Improve the Efficacy of Carbon Ion Radiotherapy: Experience of Gunma University.
Translational Shift of HSP90 as a Novel Therapeutic Target from Cancer to Neurodegenerative Disorders: an Emerging Trend in the Cure of Alzheimer's and Parkinson's diseases.
Translationally controlled tumor protein is a novel heat shock protein with chaperone-like activity.
Transmission of endoplasmic reticulum stress and pro-inflammation from tumor cells to myeloid cells.
TRAP-1, the mitochondrial Hsp90.
TRAP1 controls cell cycle G2-M transition through the regulation of CDK1 and MAD2 expression/ubiquitination.
TRAP1 controls cell migration of cancer cells in metabolic stress conditions: Correlations with AKT/p70S6K pathways.
TRAP1 downregulation in human ovarian cancer enhances invasion and epithelial-mesenchymal transition.
TRAP1 is involved in BRAF regulation and downstream attenuation of ERK phosphorylation and cell-cycle progression: a novel target for BRAF-mutated colorectal tumors.
TRAP1 Provides Protection Against Myocardial Ischemia-Reperfusion Injury by Ameliorating Mitochondrial Dysfunction.
TRAP1 regulates autophagy in lung cancer cells.
TRAP1 regulates cell cycle and apoptosis in thyroid carcinoma cells.
TRAP1 Regulates Proliferation, Mitochondrial Function and has Prognostic Significance in NSCLC.
TRAP1 Regulation of Cancer Metabolism: Dual Role as Oncogene or Tumor Suppressor.
TRAP1 regulation of mitochondrial life or death decision in cancer cells and mitochondria-targeted TRAP1 inhibitors.
TRAP1 revisited: novel localizations and functions of a 'next-generation' biomarker (review).
TRAP1 shows clinical significance and promotes cellular migration and invasion through STAT3/MMP2 pathway in human esophageal squamous cell cancer.
Treatment of ras-induced cancers by the F-actin-bundling drug MKT-077.
Trefoil factor 1 (TFF1/pS2) deficiency activates the unfolded protein response.
Trends in the early investigational drug development and areas for improvement.
Triazole Containing Novobiocin and Biphenyl Amides as Hsp90 C-Terminal Inhibitors.
Triggering senescence programs suppresses Chk1 kinase and sensitizes cells to genotoxic stresses.
Triptolide induces the expression of miR-142-3p: a negative regulator of heat shock protein 70 and pancreatic cancer cell proliferation.
Triptolide therapy for neuroblastoma decreases cell viability in vitro and inhibits tumor growth in vivo.
Tuberous sclerosis complex protein 1 expression is affected by VHL Gene alterations and HIF-1? production in sporadic clear-cell renal cell carcinoma.
Tubocapsenolide A targets C-terminal cysteine residues of HSP90 to exert the anti-tumor effect.
Tumor antigen delivered by Salmonella III secretion protein fused with heat shock protein 70 induces protection and eradication against murine melanoma.
Tumor cell expression of heat shock protein (HSP) 72 is influenced by HSP72 [HSPA1B A(1267)G] polymorphism and predicts survival in small Cell lung cancer (SCLC) patients.
Tumor cell membrane-bound heat shock protein 70 elicits antitumor immunity.
Tumor Cell Surface Display of Immunoglobulin Heavy Chain Fc by Gene Transfer as a Means to Mimic Antibody Therapy.
Tumor cell surface display of immunoglobulin heavy chain Fc by gene transfer as a means to mimic antibody therapy.
Tumor heterogeneity, clonal evolution, and therapy resistance: an opportunity for multitargeting therapy.
Tumor Immune Systems in Esophageal Cancer with Special Reference to Heat-shock Protein 70 and Humoral Immunity.
Tumor immunity and prolonged survival following combined adenovirus-HSP72 and CEA-plasmid vaccination.
Tumor immunogenicity is determined by the mechanism of cell death via induction of heat shock protein expression.
Tumor induces muscle wasting in mice through releasing extracellular Hsp70 and Hsp90.
Tumor necrosis factor acts as a tumor promoter in BALB/3T3 cell transformation.
Tumor necrosis factor induces the rapid phosphorylation of the mammalian heat shock protein hsp28.
Tumor Necrosis Factor Receptor-associated Protein 1 (TRAP1) Mutation and TRAP1 Inhibitor Gamitrinib-triphenylphosphonium (G-TPP) Induce a Forkhead Box O (FOXO)-dependent Cell Protective Signal from Mitochondria.
Tumor necrosis factor receptor-associated protein 1(TRAP1) regulates genes involved in cell cycle and metastases.
Tumor necrosis factor-alpha and alphaB-crystallin up-regulation during antibody-mediated demyelination in vitro: a putative protective mechanism in oligodendrocytes.
Tumor necrosis factor-alpha-induced expression of heat shock protein 72 in adult feline cardiac myocytes.
Tumor prevention and antitumor immunity with heat shock protein 70 induced by 15-deoxy-delta12,14-prostaglandin J2 in transgenic adenocarcinoma of mouse prostate cells.
Tumor response to mTHPC-mediated photodynamic therapy exhibits strong correlation with extracellular release of HSP70.
Tumor secreted Hsp90 subverts Polycomb function to drive prostate tumor growth and invasion.
Tumor selectivity of Hsp90 inhibitors: the explanation remains elusive.
Tumor specific binding of radiolabeled PEGylated GIRLRG peptide; a novel agent for targeting cancers.
Tumor suppression by apoptotic and anti-angiogenic effects of mortalin-targeting adeno-oncolytic virus.
Tumor Suppression Efficacy of Heat Shock Protein 90 Inhibitor 17AAG in a Liposarcoma Mouse Model.
Tumor suppressor function of Betaig-h3 gene in radiation carcinogenesis.
Tumor suppressor HLJ1 binds and functionally alters nucleophosmin via activating enhancer binding protein 2alpha complex formation.
Tumor suppressor Tsc1 is a new Hsp90 co-chaperone that facilitates folding of kinase and non-kinase clients.
Tumor-derived heat shock protein 70-pulsed dendritic cells elicit tumor-specific cytotoxic T lymphocytes (CTLs) and tumor immunity.
Tumor-derived, chaperone-rich cell lysate activates dendritic cells and elicits potent antitumor immunity.
Tumor-induced angiogenesis studied in confrontation cultures of multicellular tumor spheroids and embryoid bodies grown from pluripotent embryonic stem cells.
Tumor-Intrinsic and Tumor-Extrinsic Factors Impacting Hsp90-Targeted Therapy.
Tumor-Microenvironment-Responsive Nanoconjugate for Synergistic Antivascular Activity and Phototherapy.
Tumor-released autophagosomes induces CD4+ T cell-mediated immunosuppression via a TLR2-IL-6 cascade.
Tumor-secreted GRP78 facilitates the migration of macrophages into tumors by promoting cytoskeleton remodeling.
Tumor-Secreted GRP78 Promotes the Establishment of a Pre-metastatic Niche in the Liver Microenvironment.
Tumor-suppressive effect of a telomerase-derived peptide by inhibiting hypoxia-induced HIF-1?-VEGF signaling axis.
Tumor-targeted SN38 inhibits growth of early stage non-small cell lung cancer (NSCLC) in a KRas/p53 transgenic mouse model.
Tumour cell blebbing and extracellular vesicle shedding: key role of matrikines and ribosomal protein SA.
Tumour cell expression of interleukin 6 receptor ? is associated with response rates in patients treated with sunitinib for metastatic clear cell renal cell carcinoma.
Tumour eradication using synchronous thermal ablation and Hsp90 chemotherapy with protein engineered triblock biopolymer-geldanamycin conjugates.
Tumour necrosis factor-alpha production stimulated by heat shock protein 70 and its inhibition in circulating dendritic cells and cells eluted from mucosal tissues in Crohn's disease.
Tumour progression: random mutations or an integrated survival response to cellular stress conserved from unicellular organisms?
Tumour rejection antigens of the hsp90 family (gp96) closely resemble tumour-associated heparanase enzymes.
Tunicamycin-induced ER stress in breast cancer cells neither expresses GRP78 on the surface nor secretes it into the media.
Two-dimensional gel analysis of protein expression profile in squamous cervical cancer patients.
Ubiquitin-like (UBX)-domain-containing protein, UBXN2A, promotes cell death by interfering with the p53-Mortalin interactions in colon cancer cells.
UBR1 promotes protein kinase quality control and sensitizes cells to Hsp90 inhibition.
UDP glucuronosyltransferase 1A expression levels determine the response of colorectal cancer cells to the heat shock protein 90 inhibitor ganetespib.
Ultrafast Low-Temperature Photothermal Therapy Activates Autophagy and Recovers Immunity for Efficient Antitumor Treatment.
Ultrasensitive analysis of heat shock protein 90? with antibodies orderly arrayed on a novel type of immunoprobe based on magnetic COFs.
Ultrasound irradiation inhibits proliferation of cervical cancer cells by initiating endoplasmic reticulum stress-mediated apoptosis and triggering phosphorylation of JNK.
Ultrasound Targeted Microbubble Destruction for Novel Dual Targeting of HSP72 and HSC70 in Prostate Cancer.
Unbiased in vivo preclinical evaluation of anticancer drugs identifies effective therapy for the treatment of pancreatic adenocarcinoma.
Uncovering biosynthetic potential of plant-associated fungi: effect of culture conditions on metabolite production by Paraphaeosphaeria quadriseptata and Chaetomium chiversii.
Understanding conformational diversity of heat shock protein 90 (HSP90) and binding features of inhibitors to HSP90 via molecular dynamics simulations.
Understanding the Hsp90 N-terminal Dynamics: Structural and Molecular Insights into the Therapeutic Activities of Anticancer Inhibitors Radicicol (RD) and Radicicol Derivative (NVP-YUA922).
Unfolded protein response signaling impacts macrophage polarity to modulate breast cancer cell clearance and melanoma immune checkpoint therapy responsiveness.
Unilateral Ureteral Obstruction as a Model to Investigate Fibrosis-Attenuating Treatments.
Unleashing the full potential of Hsp90 inhibitors as cancer therapeutics through simultaneous inactivation of Hsp90, Grp94, and TRAP1.
Untangling the unfolded protein response.
Unusual expression and localization of heat-shock proteins in human tumor cells.
Unusual Suspects in the Twilight Zone Between the Hsp90 Interactome and Carcinogenesis.
Up-regulation of 150-kDa oxygen-regulated protein by celecoxib in human gastric carcinoma cells.
Up-regulation of heat shock protein 70 in adenocarcinomas of the lung in smokers.
Update on Hsp90 Inhibitors in Clinical Trial.
Update on immunotherapy for melanoma.
Upon oxidative stress, the antiapoptotic Hsp60/procaspase-3 complex persists in mucoepidermoid carcinoma cells.
Upregulated Heat Shock Proteins After Hyperthermic Chemotherapy Point to Induced Cell Survival Mechanisms in Affected Tumor Cells From Peritoneal Carcinomatosis.
Upregulated HSPA2 predicts early relapse of pancreatic cancer after surgery.
Upregulation of collagenase-1 and -3 in indomethacin-induced gastric ulcer in diabetic rats: role of melatonin.
Upregulation of Glucose-Regulated Protein 78 in Metastatic Cancer Cells Is Necessary for Lung Metastasis Progression.
Upregulation of GRP78 in Renal Cell Carcinoma and Its Significance.
Upregulation of heat shock protein 70 and the differential protein expression induced by tumor necrosis factor-alpha enhances migration and inhibits apoptosis of hepatocellular carcinoma cell HepG2.
Upregulation of heat shock proteins (HSPA12A, HSP90B1, HSPA4, HSPA5 and HSPA6) in tumour tissues is associated with poor outcomes from HBV-related early-stage hepatocellular carcinoma.
Upregulation of heat shock protein 27 confers resistance to actinomycin D-induced apoptosis in cancer cells.
Upregulation of mortalin/mthsp70/Grp75 contributes to human carcinogenesis.
Upstream sequences required for efficient expression of a soybean heat shock gene.
Use of autoantibodies against tumor-associated antigens as serum biomarkers for primary screening of cervical cancer.
Use of in vivo bioluminescence and MRI to determine hyperthermia-induced changes in luciferase activity under the control of an hsp70 promoter.
Use of protein-based biomarkers of exfoliated cervical cells for primary screening of cervical cancer.
Use of the glucose starvation-inducible glucose-regulated protein 78 promoter in suicide gene therapy of murine fibrosarcoma.
Using natural product inhibitors to validate Hsp90 as a molecular target in cancer.
Utilizing integrating network pharmacological approaches to investigate the potential mechanism of Ma Xing Shi Gan Decoction in treating COVID-19.
V600E B-Raf requires the Hsp90 chaperone for stability and is degraded in response to Hsp90 inhibitors.
Vaccination of metastatic melanoma patients with autologous tumor-derived heat shock protein gp96-peptide complexes: clinical and immunologic findings.
Vaccination with B16 tumor cell lysate plus recombinant Mycobacterium tuberculosis Hsp70 induces antimelanoma effect in mice.
Vaccination with TCL plus MHSP65 induces anti-lung cancer immunity in mice.
Vaginal nitric oxide in pregnant women with bacterial vaginosis.
Validation of heat shock protein 70 as a tumor-specific biomarker for monitoring the outcome of radiation therapy in tumor mouse models.
Validation of the Hsp70-Bag3 Protein-Protein Interaction as a Potential Therapeutic Target in Cancer.
Variations in HSPA1B at 6p21.3 are associated with lung cancer risk and prognosis in Chinese populations.
Vascular attack by 5,6-dimethylxanthenone-4-acetic acid combined with B7.1 (CD80)-mediated immunotherapy overcomes immune resistance and leads to the eradication of large tumors and multiple tumor foci.
Vascular targeting and antiangiogenesis agents induce drug resistance effector GRP78 within the tumor microenvironment.
Vaspin Is an Adipokine Ameliorating ER Stress in Obesity as a Ligand for Cell-Surface GRP78/MTJ-1 Complex.
Vincristine ablation of Sirt2 induces cell apoptosis and mitophagy via Hsp70 acetylation in MDA-MB-231 cells.
Virtual prototyping study shows increased ATPase activity of Hsp90 to be the key determinant of cancer phenotype.
Virtual screening and biophysical studies lead to HSP90 inhibitors.
Virtual screening based identification of miltefosine and octenidine as inhibitors of heat shock protein 90.
Visceral regeneration in a sea cucumber involves extensive expression of survivin and mortalin homologs in the mesothelium.
Visualizing and Quantifying the Effect of the Inhibition of HSP70 on Breast Cancer Cells Based on Laser Scanning Microscopy.
Vitespen: a preclinical and clinical review.
Volume of Hsp90 Protein-Ligand Binding Determined by Fluorescent Pressure Shift Assay, Densitometry, and NMR.
Water amino acid-chelated trace mineral supplementation decreases circulating and intestinal HSP70 and proinflammatory cytokine gene expression in heat-stressed broiler chickens.
What we know about ST13, a co-factor of heat shock protein, or a tumor suppressor?
Wild-type EGFR Is Stabilized by Direct Interaction with HSP90 in Cancer Cells and Tumors.
Withaferin A targets heat shock protein 90 in pancreatic cancer cells.
Withania somnifera Suppresses Tumor Growth of Intracranial Allograft of Glioma Cells.
Withanolides-induced breast cancer cell death is correlated with their ability to inhibit heat protein 90.
Withanone binds to mortalin and abrogates mortalin-p53 complex: Computational and experimental evidence.
WLS/wntless is essential in controlling dendritic cell homeostasis via a WNT signaling-independent mechanism.
Words of wisdom. Re: Targeting the regulation of androgen receptor signaling by the heat shock protein 90 cochaperone FKBP52 in prostate cancer cells.
X-linked inhibitor of apoptosis protein (XIAP) is a client of heat shock protein 70 (Hsp70) and a biomarker of its inhibition.
X66, a novel N-terminal heat shock protein 90 inhibitor, exerts antitumor effects without induction of heat shock response.
Y-632 inhibits Hsp90 function through disrupting the interaction of Hsp90-Hop and exerts antitumor activity in vitro and in vivo.
Zika virus envelope - heat shock protein A5 (GRP78) binding site prediction.
[2 + 2 + 2] Cyclotrimerization with Propargyl Halides as Copartners: Formal Total Synthesis of the Antitumor Hsp90 Inhibitor AT13387.
[Allogeneic dendritic cell vaccine pulsed with heat shocked tumor cell lysate can enhance antitumor immunity]
[Association of occupational chronic psychological stress with heat shock protein 70 in serum and tumor necrosis factor-alpha expression levels].
[Biology behavior of head and neck squamous cell cancer cells changes after knocking down heat shock protein 27].
[Correlation of heat shock protein 70 expression in nasopharyngeal carcinoma to immunoglobin A against viral capsid antigen of Epstein-Barr virus in sera and its clinical significance]
[Development of myeloproliferative neoplasms by mutant calreticulin: underlying mechanisms].
[Diagnostic and Therapeutic Potential of Membrane HSP90].
[Differential expression of secretagogin and glucose-related protein 78 in colorectal carcinoma: a proteome study]
[Down-regulation of GRP78 Enhances Chemotherapy Sensitivity to VP-16 in Lung Adenocarcinoma.]
[Effect of heat shock protein 90 inhibitor 17-dimethylamino-ethylaminogeldanamycin on TNfalpha-mediated apoptosis and TNF-induced NF-kappaB activation].
[Effect of ketamine on endotoxin-induced septic shock in rats and its mechanism]
[Effects of ascites derived exosomes on the stemness and invasion ability of ovarian cancer stem-like cell].
[Effects of centimeter waves on the immune system of mice in endotoxic shock]
[Effects of HMGB1 inhibition on endoplasmic reticulum stress after myocardial ischemia/reperfusion injury in rats].
[Effects of HSP90 inhibitor 17-AAG on cell cycle and apoptosis of human gastric cancer cell lines SGC-7901].
[Effects of pre-heating on the sensitivity of K562 cell to tumor necrosis factor-alpha]
[Endoplasmic Reticulum Chaperones at the Tumor Cell Surface and in the Extracellular Space].
[Expression and significance of heat shock protein 70, 90 in endometrial carcinomas]
[Expression of heat shock protein 90 alpha and its effect on the growth of tumor in mice]
[Expression of heat shock proteins in salivary gland tumors. Immunohistochemical study of HSP27, HSP70, HSP90, and HSP110: apropos of 50 cases]
[Expression of HSP70 and P-glycoprotein (P-gp) in human hepatocarcinoma HepG2 cells induced by heat shock and inhibiting effect of quercetin on them]
[Expression of P53 and heat shock protein in colorectal tumors: an immunohistochemical study]
[Expressions of heat shock protein (HSP) family HSP 60, 70 and 90alpha in colorectal cancer tissues and their correlations to pathohistological characteristics.]
[Ginsenoside Rh?-induced inhibition of histone deacetylase 6 promotes K562 cells autophagy and apoptosis in vivo].
[Glucose regulated protein 78 kD]
[Heat sensitivity of human cancer cells and abnormal expression of heat shock protein 70]
[Heat shock protein 70 binding protein 1 induces enhanced apoptotic response against anticancer drugs in tumor cells]
[Heat shock protein 70 induction by heat stress suppress interleukin-1beta and tumor necrosis factor-alpha levels in the brain tissue in rats with infectious brain edema]
[Heat shock protein 70: an important survival factor for cancer cells]
[Heat shock protein 90--modulator of TNFalpha-induced apoptosis of Jurkat tumor cells].
[Heat shock protein 90: novel target for cancer therapy]
[Heat shock proteins and malignancies of the female genital tract]
[Heat shock proteins: new target in cytoprotective and tumor therapy]
[Hsp70-H22 tumor antigen peptide complex activated dendritic cell in the induction of antitumor immunity]
[Hsp90--a target for anticancer therapy].
[Hsp90AB1 Protein is Overexpressed in Non-small Cell Lung Cancer Tissues ?and Associated with Poor Prognosis in Lung Adenocarcinoma Patients].
[Immune activity of heat shock protein gp96 and its application in active immunotherapy for tumor and infectious diseases].
[Immunocorrective effect of low intensity radiation of ultrahigh frequency on carcinogenesis in mice]
[Impact of HSP90 Inhibition on Viability and Cell Cycle in Relation to p53 Status].
[Inhibitors of the heat shock protein 90 activity: a novel class of tumor radiosensitizers].
[Large-scale in vitro preparation of new gp96 tumor vaccine and analysis of its induction of specific anti-tumor immunoresponses].
[Levels of cytokines and heat-shock protein 70 in the seminal plasma of patients with chronic bacterial prostatitis and chronic prostatitis/chronic pelvic pain syndrome].
[Mechanism of TTF1-NP induced implanted hepatoma tumor apoptosis in nude mice by endoplasmic reticulum stress pathway].
[Mechanisms of the drug resistance of a 2', 2-difluorodeoxycytide (gemcitabine)-resistant variant of the human lung adenocarcinoma cell line]
[Mitochondria HSP90: the target to inactivate in cancer therapy?]
[Molecular chaperone HSP90 as a novel target for cancer chemotherapy]
[Overexpression of heat shock protein 70 and spontaneous cancer cell apoptosis in hepatocellular carcinoma]
[Pancreatic acinar neoplasms : Comparative molecular characterization].
[Parallelism and paradoxes on viability and the life span of two loss-of-function mutations: heat shock protein transcriptional regulator hsf(1) and l(2)gl tumor suppressor in D. melanogaster].
[Preliminary study on the antitumor immuno-protective mechanism of beta-elemene]
[Progress in molecular chaperones participating in regulations of plant and animal development and evolution]
[Progress in the study of heat shock protein 90 inhibitors]
[Progress in the study of small molecule inhibitors of HSP90].
[Relationship between chemosensitivity in vitro and the expression of GRP78 in non-small cell lung cancer.]
[RNA Interference targeting GRP75 decreases cisplatin resistance in human lung adenocarcinoma cell].
[Role and mechanism of cAMP/Ca 2+ signal pathway in differentiation of bone marrow mesenchymal stem cells into neuronal cells induced by salidroside].
[Role of heat shock protein-peptide complexes on tumor and infectious diseases immunity]
[Screening of citrullinated proteins in ten tumor cell lines].
[Steroid hormonal receptors, heat shock protein and p53 of endometrioid and clear cell cancers in different localization]
[The correlation between the up-regulation of Hsp90 and drug resistance to cisplatin in lung cancer cell line].
[The protective effect of heat shock protein 72 by Doxorubicin in cold ischemia-reperfusion injury of the rat liver]
[The Role of Membrane-Bound Heat Shock Proteins Hsp90 in Migration of Tumor Cells in vitro and Involvement of Cell Surface Heparan Sulfate Proteoglycans in Protein Binding to Plasma Membrane].
[The role of the heat shock protein in human breast cancer]
[Thermosensitization of tumor cells with inhibitors of chaperone activity and expression].
[Tumor rejection antigen and cancer immunotherapy]
Neoplasms, Germ Cell and Embryonal
Testis cancer.
Neoplasms, Glandular and Epithelial
Expression and localization of GRP75 in human epithelial tumors and normal tissues.
Neoplasms, Neuroepithelial
Different immunohistochemical levels of Hsp60 and Hsp70 in a subset of brain tumors and putative role of Hsp60 in neuroepithelial tumorigenesis.
Neoplasms, Plasma Cell
Expression of heat-shock protein-90 in non-Hodgkin's lymphomas.
Neoplasms, Squamous Cell
Erratum to: Novel C-terminal Hsp90 Inhibitor for Head and Neck Squamous Cell Cancer (HNSCC) with in vivo Efficacy and Improved Toxicity Profiles Compared with Standard Agents.
Inhibition of heat shock protein 90 suppresses squamous carcinogenic progression in a mouse model of esophageal cancer.
Novel C-Terminal Hsp90 Inhibitor for Head and Neck Squamous Cell Cancer (HNSCC) with in vivo Efficacy and Improved Toxicity Profiles Compared with Standard Agents.
Silencing heat shock protein 27 decreases metastatic behavior of human head and neck squamous cell cancer cells in vitro.
[Biology behavior of head and neck squamous cell cancer cells changes after knocking down heat shock protein 27].
Neoplastic Processes
Identification of molecular candidates and interaction networks via integrative toxicogenomic analysis in a human cell line following low-dose exposure to the carcinogenic metals cadmium and nickel.
Nephritis
Heat shock protein 60 is released in immune-mediated glomerulonephritis and aggravates disease: in vivo evidence for an immunologic danger signal.
Heat shock protein 70-2 and tumor necrosis factor-? gene polymorphisms in Chinese children with Henoch-Schönlein purpura.
Nephritis, Interstitial
T cells reactive to an inducible heat shock protein induce disease in toxin-induced interstitial nephritis.
Nephrosis, Lipoid
Renal tubular expression of Toll-like receptor 4 in cyclosporine nephrotoxicity.
Nephrotic Syndrome
Abnormal expression and distribution of heat shock protein 90: potential etiologic immunoendocrine mechanism of glucocorticoid resistance in idiopathic nephrotic syndrome.
Altered expression of glomerular heat shock protein 27 in experimental nephrotic syndrome.
Differential induction of podocyte heat shock proteins by prolonged single and combination toxic metal exposure.
HSP27/HSPB1 as an adaptive podocyte antiapoptotic protein activated by high glucose and angiotensin II.
Nuclear HSP90 regulates the glucocorticoid responsiveness of PBMCs in patients with idiopathic nephrotic syndrome.
Renal tubular expression of Toll-like receptor 4 in cyclosporine nephrotoxicity.
Nerve Sheath Neoplasms
Immunohistochemical Evaluation of Heat Shock Protein Expression in Normal Canine Nerve and Peripheral Nerve Sheath Tumours.
Nervous System Diseases
Chaperone-dependent Neurodegeneration: A Molecular Perspective on Therapeutic Intervention.
Expression of the human groEL stress-protein homologue in the brain and spinal cord.
First Structural View of a Peptide Interacting with the Nucleotide Binding Domain of Heat Shock Protein 90.
Geldanamycin induces heat shock protein 70 and protects against MPTP-induced dopaminergic neurotoxicity in mice.
Glucose-regulated protein (GRP78) is an important cell surface receptor for viral invasion, cancers, and neurological disorders.
Heat shock protein-70 (Hsp-70) suppresses paraquat-induced neurodegeneration by inhibiting JNK and caspase-3 activation in Drosophila model of Parkinson's disease.
Hsp60 response in experimental and human temporal lobe epilepsy.
Human TorsinA can function in the yeast cytosol as a molecular chaperone.
Role of glucose-regulated Protein 78 in embryonic development and neurological disorders.
[Glucose regulated protein 78 kD]
Neural Tube Defects
Heat shock proteins Hsp70-1 and Hsp70-3 Are necessary and sufficient to prevent arsenite-induced dysmorphology in mouse embryos.
Hectd1 regulates intracellular localization and secretion of Hsp90 to control cellular behavior of the cranial mesenchyme.
In vitro analysis of the murine heat shock response: implications for reproductive toxicology.
Neuralgia
Evidence for a role of heat shock protein-90 in toll like receptor 4 mediated pain enhancement in rats.
Heat-shock protein 90 (Hsp90) promotes opioid-induced anti-nociception by an ERK mitogen-activated protein kinase (MAPK) mechanism in mouse brain.
Neurilemmoma
Binding partners for curcumin in human schwannoma cells: biologic implications.
Elevated levels of mortalin expression in human brain tumors.
Expression of HSP90 in gastrointestinal stromal tumours and mesenchymal tumours.
Schwann cell autophagy induced by SAHA, 17-AAG, or clonazepam can reduce bortezomib-induced peripheral neuropathy.
Neuritis
Toll-like receptor-2, CD14 and heat-shock protein 70 in inflammatory lesions of rat experimental autoimmune neuritis.
Neuritis, Autoimmune, Experimental
Toll-like receptor-2, CD14 and heat-shock protein 70 in inflammatory lesions of rat experimental autoimmune neuritis.
Neuroblastoma
17AAG Treatment Accelerates Doxorubicin Induced Cellular Senescence: Hsp90 Interferes with Enforced Senescence of Tumor Cells.
A Novel Mechanism of 17-AAG Therapeutic Efficacy on HSP90 Inhibition in MYCN-Amplified Neuroblastoma Cells.
A Novel MYCN-Specific Antigene Oligonucleotide Deregulates Mitochondria and Inhibits Tumor Growth in MYCN-Amplified Neuroblastoma.
Binding of tissue-type plasminogen activator to the glucose-regulated protein 78 (GRP78) modulates plasminogen activation and promotes human neuroblastoma cell proliferation in vitro.
Biological Activity of a Thiobarbituric Acid Compound in Neuroblastomas.
CCAR2/DBC1 and Hsp60 Positively Regulate Expression of Survivin in Neuroblastoma Cells.
Cell-type variation in stress responses as a consequence of manipulating GRP78 expression in neuroectodermal cells.
Changes in heat shock protein 70 and ubiquitin mRNA levels in C1300 N2A mouse neuroblastoma cells following treatment with iron.
Characterization of promoter elements mediating ethanol regulation of hsc70 gene transcription.
Comparative non-cholinergic neurotoxic effects of paraoxon and diisopropyl fluorophosphate (DFP) on human neuroblastoma and astrocytoma cell lines.
Compromising the constitutive p16INK4a expression sensitizes human neuroblastoma cells to Hsp90 inhibition and promotes premature senescence.
Curcumin Affects HSP60 Folding Activity and Levels in Neuroblastoma Cells.
Decrease of neuronal FKBP4/FKBP52 modulates perinuclear lysosomal positioning and MAPT/Tau behavior during MAPT/Tau-induced proteotoxic stress.
Does ORP150/HSP12A protect dopaminergic neurons against MPTP/MPP(+)-induced neurotoxicity?
Down modulation of N-myc, heat-shock protein 70, and nucleolin during the differentiation of human neuroblastoma cells.
Downregulation of DNAJC10 (ERDJ5) is associated with poor survival in breast cancer.
Downregulation of miRNA-134 protects neural cells against ischemic injury in N2A cells and mouse brain with ischemic stroke by targeting HSPA12B.
Dynamic Interaction of USP14 with the Chaperone HSC70 Mediates Crosstalk between the Proteasome, ER Signaling, and Autophagy.
Dysregulated LRRK2 Signaling in Response to Endoplasmic Reticulum Stress Leads to Dopaminergic Neuron Degeneration in C. elegans.
Effect of heat shock on intracellular calcium mobilization in neuroblastoma x glioma hybrid cells.
Effect of let-7c on the PI3K/Akt/FoxO signaling pathway in hepatocellular carcinoma.
Effects of alcohol on gene expression in neural cells.
Effects of celastrol on Tau hyperphosphorylation and expression of HSF-1 and HSP70 in SH-SY5Y neuroblastoma cells induced by amyloid-? peptides.
Effects of Hsp90 inhibition in neuroblastoma: analysis of drug sensitivity, target modulation and the influence of bone marrow microenvironment.
Ethanol promotes endoplasmic reticulum stress-induced neuronal death: involvement of oxidative stress.
Ethanol-responsive genes in neural cells include the 78-kilodalton glucose-regulated protein (GRP78) and 94-kilodalton glucose-regulated protein (GRP94) molecular chaperones.
Exogenous heat shock protein HSP70 reduces response of human neuroblastoma cells to lipopolysaccharide.
Expression of heat shock protein 90 at the cell surface in human neuroblastoma cells.
Expression patterns of Trk-A, Trk-B, GRP78, and p75NRT in olfactory neuroblastoma.
GRP78 expression correlates with histologic differentiation and favorable prognosis in neuroblastic tumors.
H9724, a monoclonal antibody to Borrelia burgdorferi's flagellin, binds to heat shock protein 60 (HSP60) within live neuroblastoma cells: a potential role for HSP60 in peptide hormone signaling and in an autoimmune pathogenesis of the neuropathy of Lyme disease.
Heat shock protein 104 inhibited the fibrillization of prion peptide 106-126 and disassembled prion peptide 106-126 fibrils in vitro.
Heat shock protein 70 induction by glutamine increases the ?-synuclein degradation in SH-SY5Y neuroblastoma cells.
Heat shock protein 70 modulates neural progenitor cells dynamics in human neuroblastoma SH-SY5Y cells exposed to high glucose content.
Heat shock protein 90 and heat shock protein 70 are components of dengue virus receptor complex in human cells.
High Glucose Content Abrogated the Normal Activity of Heat Shock Protein Signaling Pathway in Human Neuroblastoma Cells.
Histone deacetylase 10 promotes autophagy-mediated cell survival.
HSC70 expression is reduced in lymphomonocytes of sporadic ALS patients and contributes to TDP-43 accumulation.
Hsp90 inhibition increases p53 expression and destabilizes MYCN and MYC in neuroblastoma.
Hsp90 inhibitors deplete key anti-apoptotic proteins in pediatric solid tumor cells and demonstrate synergistic anticancer activity with cisplatin.
Hsp90-mediated inhibition of FKBP38 regulates apoptosis in neuroblastoma cells.
HSPA8 knock-down induces the accumulation of neurodegenerative disorder-associated proteins.
Hyperbaric oxygen enhances the expression of prion protein and heat shock protein 70 in a mouse neuroblastoma cell line.
Hypoglycemia enhances the expression of prion protein and heat-shock protein 70 in a mouse neuroblastoma cell line.
Identification of GRP75 as an independent favorable prognostic marker of neuroblastoma by a proteomics analysis.
Immunophilin FK506-binding protein 52 (not FK506-binding protein 12) mediates the neurotrophic action of FK506.
Indolyl- and Pyrrolylazine Derivatives Cause the Accumulation of Heat Shock Protein Hsp70 in Sh-Sy5Y Human Neuroblastoma Cells.
Inhibition of neuroblastoma xenograft growth by Hsp90 inhibitors.
Interaction of ethanol with inducers of glucose-regulated stress proteins. Ethanol potentiates inducers of grp78 transcription.
Localization and quantitation of hsp84 in mammalian cells.
Mechanisms of neuronal adaptation to ethanol. Ethanol induces Hsc70 gene transcription in NG108-15 neuroblastoma x glioma cells.
Methylation-associated silencing of the heat shock protein 47 gene in human neuroblastoma.
Multiple protein kinases determine the phosphorylated state of the small heat shock protein, HSP27, in SH-SY5Y neuroblastoma cells.
Neural differentiation and the attenuated heat shock response.
Neuronal hypoxia induces Hsp40-mediated nuclear import of type 3 deiodinase as an adaptive mechanism to reduce cellular metabolism.
Nuclear GRP75 binds retinoic acid receptors to promote neuronal differentiation of neuroblastoma.
Nuclear translocation and aggregate formation of heat shock cognate protein 70 (Hsc70) in oxidative stress and apoptosis.
Oxygen free radicals as inducers of heat shock protein synthesis in cultured human neuroblastoma cells: relevance to neurodegenerative disease.
Presenilin-1 mutations downregulate the signalling pathway of the unfolded-protein response.
Prostaglandin J2 alters pro-survival and pro-death gene expression patterns and 26 S proteasome assembly in human neuroblastoma cells.
Proteomic analysis of protein complexes in human SH-SY5Y neuroblastoma cells by using blue-native gel electrophoresis: An increase in lamin A/C associated with heat shock protein 90 in response to 6-hydroxydopamine-induced oxidative stress.
Proteomic Analysis on Anti-Proliferative and Apoptosis Effects of Curcumin Analog, 1,5-bis(4-Hydroxy-3-Methyoxyphenyl)-1,4-Pentadiene-3-One-Treated Human Glioblastoma and Neuroblastoma Cells.
Proteomic identification of heat shock protein 27 as a differentiation and prognostic marker in neuroblastoma but not in Ewing's sarcoma.
Repercussion of Mitochondria Deformity Induced by Anti-Hsp90 Drug 17AAG in Human Tumor Cells.
Rotenone down-regulates HSPA8/hsc70 chaperone protein in vitro: A new possible toxic mechanism contributing to Parkinson's disease.
Rotenone Upregulates Alpha-Synuclein and Myocyte Enhancer Factor 2D Independently from Lysosomal Degradation Inhibition.
SPARC overexpression suppresses radiation-induced HSP27 and induces the collapse of mitochondrial ?? in neuroblastoma cells.
The basal flux of Akt in the mitochondria is mediated by heat shock protein 90.
The neuroblastoma tumour-suppressor TrkAI and its oncogenic alternative TrkAIII splice variant exhibit geldanamycin-sensitive interactions with Hsp90 in human neuroblastoma cells.
The protective role of HSP90 against 3-hydroxykynurenine-induced neuronal apoptosis.
The surface-exposed chaperone, Hsp60, is an agonist of the microglial TREM2 receptor.
The systemic amyloid precursor transthyretin (TTR) behaves as a neuronal stress protein regulated by HSF1 in SH-SY5Y human neuroblastoma cells and APP23 Alzheimer's disease model mice.
The tumour-suppressive function of CLU is explained by its localisation and interaction with HSP60.
Thiopental protects human neuroblastoma cells from apoptotic cell death - Potential role of heat shock protein 70.
Translational downregulation of HSP90 expression by iron chelators in neuroblastoma cells.
Trehalose induces autophagy via lysosomal-mediated TFEB activation in models of motoneuron degeneration.
[Effects of the Hydrogen Sulfide Donor GYY4137 and HSP70 Protein on the Activation of SH-SY5Y Cells by Lipopolysaccharide].
[Exogenous HSP70 and Signaling Pathways Involved in the Inhibition of LPS-Induced Neurotoxicity of Neuroblastoma Cells].
[Expression of heat-shock proteins in neuroblastoma cells differing genetically in thermal sensitivity]
[Molecular chaperone Hsp70 protects neuroblastoma SK-N-SH cells from hypoxic stress]
[The Effect of Beta-Amyloid Peptides and Main Stress Protein HSP70 on Human SH-SY5Y Neuroblastoma Proteome].
Neurocysticercosis
Taenia solium: characterization of a small heat shock protein (Tsol-sHSP35.6) and its possible relevance to the diagnosis and pathogenesis of neurocysticercosis.
Neurodegenerative Diseases
3-Arylcoumarin derivatives manifest anti-proliferative activity through Hsp90 inhibition.
A cell model to study different degrees of Hsp60 deficiency in HEK293 cells.
A CNS-permeable Hsp90 inhibitor rescues synaptic dysfunction and memory loss in APP-overexpressing Alzheimer's mouse model via an HSF1-mediated mechanism.
A High-Throughput Screen for Inhibitors of the Hsp90-Chaperone Machine.
A Novel Hsp90 Inhibitor Activates Compensatory Heat Shock Protein Responses and Autophagy and Alleviates Mutant A53T ?-Synuclein Toxicity.
A role for astrocytes in cerebellar deficits in frataxin deficiency: Protection by insulin-like growth factor I.
A role of small heat shock protein B8 (HspB8) in the autophagic removal of misfolded proteins responsible for neurodegenerative diseases.
AAA+ Protein-Based Technologies to Counter Neurodegenerative Disease.
Acetylcarnitine induces heme oxygenase in rat astrocytes and protects against oxidative stress: involvement of the transcription factor Nrf2.
Activation of PP2A-like phosphatase and modulation of tau phosphorylation accompany stress-induced apoptosis in cultured oligodendrocytes.
Alleviating neurodegeneration by an anticancer agent: an Hsp90 inhibitor (17-AAG).
alphaB-crystallin (HspB5) in familial amyloidotic polyneuropathy.
Approaches for defining the Hsp90-dependent proteome.
Archaeal Unfoldase Counteracts Protein Misfolding Retinopathy in Mice.
Augmentation of Bri2 molecular chaperone activity against amyloid-? reduces neurotoxicity in mouse hippocampus in vitro.
Biological Evaluation of 5'-(N-Ethylcarboxamido)adenosine Analogues as Grp94-Selective Inhibitors.
Brain Aging: Hsp90 and Neurodegenerative Diseases.
Brain CHIP: removing the culprits in neurodegenerative disease.
C-terminal amino acids are essential for human heat shock protein 70 dimerization.
Characterization and Hsp104-induced artificial clearance of familial ALS-related SOD1 aggregates.
Characterization of human small heat shock protein HspB1 that carries C-terminal domain mutations associated with hereditary motor neuron diseases.
Chronic Treatment with 17-DMAG Improves Balance and Coordination in A New Mouse Model of Machado-Joseph Disease.
Combinational approach of intrabody with enhanced Hsp70 expression addresses multiple pathologies in a fly model of Huntington's disease.
Correlation between chemotype-dependent binding conformations of HSP90?/? and isoform selectivity-Implications for the structure-based design of HSP90?/? selective inhibitors for treating neurodegenerative diseases.
Covalent structural changes in unfolded GroES that lead to amyloid fibril formation detected by NMR: insight into intrinsically disordered proteins.
Critical Role of Mortalin/GRP75 In Endothelial Cell Dysfunction Associated With Acute Lung Injury.
Crystallins and neuroinflammation: The glial side of the story.
Decreased expression of the mitochondrial matrix proteases Lon and ClpP in cells from a patient with hereditary spastic paraplegia (SPG13).
Design, synthesis and biological evaluation of biphenylamide derivatives as Hsp90 C-terminal inhibitors.
Development and application of Hsp90 inhibitors.
Development of noviomimetics that modulate molecular chaperones and manifest neuroprotective effects.
Differential transport and local translation of cytoskeletal, injury-response, and neurodegeneration protein mRNAs in axons.
Discovery and development of purine-scaffold Hsp90 inhibitors.
Disparate Mutations Confer Therapeutic Gain of Hsp104 Function.
Drivers of Hsp104 potentiation revealed by scanning mutagenesis of the middle domain.
Emerging novel concept of chaperone therapies for protein misfolding diseases.
Engineering and Evolution of Molecular Chaperones and Protein Disaggregases with Enhanced Activity.
Engineering therapeutic protein disaggregases.
Exogenous Hsp70 delays senescence and improves cognitive function in aging mice.
Expression of alphaB-crystallin in a mouse model of inherited retinal degeneration.
Expression of one important chaperone protein, heat shock protein 27, in neurodegenerative diseases.
Geldanamycin induces Hsp70 and prevents alpha-synuclein aggregation and toxicity in vitro.
Heat shock protein (hsx70) mRNA expression in human brain: effects of neurodegenerative disease and agonal state.
Heat shock protein 27 in neuronal survival and neurite outgrowth.
Heat shock protein 70 selectively mediates the degradation of cytosolic PrPs and restores the cytosolic PrP-induced cytotoxicity via a molecular interaction.
Heat shock protein 90 in neurodegenerative diseases.
Heat Shock Protein 90 Inhibitors: An Update on Achievements, Challenges, and Future Directions.
Heat shock protein 90: its inhibition and function.
Heat shock protein 90: the cancer chaperone.
Heat shock proteins and neuroprotection.
Heat shock proteins at the crossroads between cancer and Alzheimer's disease.
Heat shock proteins in neurodegenerative diseases: pathogenic roles and therapeutic implications.
Heat shock proteins: a therapeutic target worth to consider.
Herbimycins D-F, Ansamycin Analogues from Streptomyces sp. RM-7-15.
High-throughput screening fluorescence polarization assay for tumor-specific hsp90.
Hsp104 and Potentiated Variants Can Operate as Distinct Nonprocessive Translocases.
Hsp104: a weapon to combat diverse neurodegenerative disorders.
Hsp60 and human aging: Les liaisons dangereuses.
HSP70 and HSP90 in neurodegenerative diseases.
Hsp70 participates in PINK1-mediated mitophagy by regulating the stability of PINK1.
Hsp90 activity is necessary to acquire a proper neuronal polarization.
Hsp90 and Its Co-Chaperones in Neurodegenerative Diseases.
Hsp90 chaperone inhibitor 17-AAG attenuates A?-induced synaptic toxicity and memory impairment.
HSP90 inhibitor CH5164840 induces micronuclei in TK6 cells via an aneugenic mechanism.
Hsp90 regulates tau pathology through co-chaperone complexes in Alzheimer's disease.
HSPA8 knock-down induces the accumulation of neurodegenerative disorder-associated proteins.
HSPA9/Mortalin mediates axo-protection and modulates mitochondrial dynamics in neurons.
HspB5/?B-crystallin phosphorylation at S45 and S59 is essential for protection of the dendritic tree of rat hippocampal neurons.
Human Molecular Chaperone Hsp60 and Its Apical Domain Suppress Amyloid Fibril Formation of ?-Synuclein.
Hydroximic Acid Derivatives: Pleiotrophic Hsp Co-Inducers Restoring Homeostasis and Robustness.
Immobilization stress induces the expression of alphaB-crystallin in rat hippocampus: implications of glial activation in stress-mediated hippocampal degeneration.
Indolyl- and Pyrrolylazine Derivatives Cause the Accumulation of Heat Shock Protein Hsp70 in Sh-Sy5Y Human Neuroblastoma Cells.
Induction of heat shock proteins may combat insulin resistance.
Induction of molecular chaperones as a therapeutic strategy for the polyglutamine diseases.
Inhibitors of heat shock protein 70 (Hsp70) with enhanced metabolic stability reduce tau levels.
Interaction of the molecular chaperone DNAJB6 with growing amyloid-beta 42 (A?42) aggregates leads to sub-stoichiometric inhibition of amyloid formation.
Interactions between Hsp70 and the hydrophobic core of alpha-synuclein inhibit fibril assembly.
Isolating potentiated Hsp104 variants using yeast proteinopathy models.
Low endogenous and chemical induced heat shock protein induction in a 0N3Rtau-expressing Drosophila larval model of Alzheimer's disease.
Mechanism of ER stress-induced brain damage by IP(3) receptor.
Mechanistic Insights into Hsp104 Potentiation.
Microglia activation triggers oligodendrocyte precursor cells apoptosis via HSP60.
Microwave-assisted one step synthesis of 8-arylmethyl-9H-purin-6-amines.
Mining Disaggregase Sequence Space to Safely Counter TDP-43, FUS, and ?-Synuclein Proteotoxicity.
MitCHAP-60 and Hereditary Spastic Paraplegia SPG-13 Arise from an Inactive hsp60 Chaperonin that Fails to Fold the ATP Synthase ?-Subunit.
Mitochondrial hsp60 chaperonopathy causes an autosomal-recessive neurodegenerative disorder linked to brain hypomyelination and leukodystrophy.
Modified biphenyl Hsp90 C-terminal inhibitors for the treatment of cancer.
Modulation of Hsp90 function in neurodegenerative disorders: a molecular-targeted therapy against disease-causing protein.
Molecular chaperone dysfunction in neurodegenerative diseases and effects of curcumin.
Molecular Chaperone ERp29: A Potential Target for Cellular Protection in Retinal and Neurodegenerative Diseases.
Molecular chaperones and neuronal proteostasis.
Molecular imaging of the efficacy of heat shock protein 90 inhibitors in living subjects.
Molecular Mechanisms Underlying Neuroprotective Effect of Intranasal Administration of Human Hsp70 in Mouse Model of Alzheimer's Disease.
Mortalin is Expressed by Astrocytes and Decreased in the Midbrain of Parkinson's Disease Patients.
Mortalin, apoptosis, and neurodegeneration.
Mortalin - a multipotent chaperone regulating cellular processes ranging from viral infection to neurodegeneration.
Natural product inhibitors of Hsp90: potential leads for drug discovery.
Neuroprotective activity and evaluation of Hsp90 inhibitors in an immortalized neuronal cell line.
Novel role of mortalin in attenuating HIV-1 Tat-mediated astrogliosis.
Old and New Approaches to Target the Hsp90 Chaperone.
Overexpression of a conserved HSP40 chaperone reduces toxicity of several neurodegenerative disease proteins.
Oxygen free radicals as inducers of heat shock protein synthesis in cultured human neuroblastoma cells: relevance to neurodegenerative disease.
p97 Homologs from Caenorhabditis elegans, CDC-48.1 and CDC-48.2, suppress the aggregate formation of huntingtin exon1 containing expanded polyQ repeat.
Pharmacologic and genetic inhibition of hsp90-dependent trafficking reduces aggregation and promotes degradation of the expanded glutamine androgen receptor without stress protein induction.
Phenotyping of tianma-stimulated differentiated rat neuronal b104 cells by quantitative proteomics.
Potential C-terminal-domain inhibitors of heat shock protein 90 derived from a C-terminal peptide helix.
Potentiated Hsp104 variants antagonize diverse proteotoxic misfolding events.
Potentiated Hsp104 variants suppress toxicity of diverse neurodegenerative disease-linked proteins.
Potentiating Hsp104 activity via phosphomimetic mutations in the middle domain.
Protective effect of geranylgeranylacetone against hydrogen peroxide-induced oxidative stress in human neuroblastoma cells.
Protective Effect of Tat PTD-Hsp27 Fusion Protein on Tau Hyperphosphorylation Induced by Okadaic Acid in the Human Neuroblastoma Cell Line SH-SY5Y.
Protein-Remodeling Factors As Potential Therapeutics for Neurodegenerative Disease.
Proteolytic stress causes heat shock protein induction, tau ubiquitination, and the recruitment of ubiquitin to tau-positive aggregates in oligodendrocytes in culture.
Purification of hsp104, a protein disaggregase.
Redox regulation of heat shock protein expression by signaling involving nitric oxide and carbon monoxide: relevance to brain aging, neurodegenerative disorders, and longevity.
Redox regulation of heat shock protein expression in aging and neurodegenerative disorders associated with oxidative stress: a nutritional approach.
Resolution-Associated Molecular Patterns (RAMPs) as Endogenous Regulators of Glia Functions in Neuroinflammatory Disease.
Roles of heat-shock protein 90 in maintaining and facilitating the neurodegenerative phenotype in tauopathies.
Roles of molecular chaperones in the nervous system.
SIRT1 Knockdown Promotes Neural Differentiation and Attenuates the Heat Shock Response.
Small heat shock proteins, the cytoskeleton, and inclusion body formation.
Spiral architecture of the Hsp104 disaggregase reveals the basis for polypeptide translocation.
Stressing Out Hsp90 in Neurotoxic Proteinopathies.
Structure of Calcarisporiella thermophila Hsp104 Disaggregase that Antagonizes Diverse Proteotoxic Misfolding Events.
Synthesis and evaluation of esterified Hsp70 agonists in cellular models of protein aggregation and folding.
Synthesis of 19-substituted geldanamycins with altered conformations and their binding to heat shock protein Hsp90.
The chaperone Grp78 in protein folding disorders of the nervous system.
The Drosophila homologue of the hereditary spastic paraplegia protein, spastin, severs and disassembles microtubules.
The Hsp60 folding machinery is crucial for manganese superoxide dismutase folding and function.
The HSP90 chaperone machinery.
The HSP90 Family: Structure, Regulation, Function, and Implications in Health and Disease.
The Molecular Chaperone GRP78/BiP as a Therapeutic Target for Neurodegenerative Disorders: A Mini Review.
The neuroprotective potential of heat shock protein 70 (HSP70).
The Role of HSP70 and Its Co-chaperones in Protein Misfolding, Aggregation and Disease.
The small heat shock protein B8 (HSPB8) efficiently removes aggregating species of dipeptides produced in C9ORF72-related neurodegenerative diseases.
The stress response: implications for the clinical development of hsp90 inhibitors.
Therapeutic genetic variation revealed in diverse Hsp104 homologs.
Thermal aggregates of human mortalin and Hsp70-1A behave as supramolecular assemblies.
To fold or not to fold: modulation and consequences of Hsp90 inhibition.
Toward Developing Chemical Modulators of Hsp60 as Potential Therapeutics.
Translational Shift of HSP90 as a Novel Therapeutic Target from Cancer to Neurodegenerative Disorders: an Emerging Trend in the Cure of Alzheimer's and Parkinson's diseases.
Trehalose induces autophagy via lysosomal-mediated TFEB activation in models of motoneuron degeneration.
[A molecular chaperone inducer as potential therapeutic agent for neurodegenerative disease]
Neuroectodermal Tumors
Cell-type variation in stress responses as a consequence of manipulating GRP78 expression in neuroectodermal cells.
Correlation between the progressive cytoplasmic expression of a novel small heat shock protein (Hsp16.2) and malignancy in brain tumors.
Targeting homeostatic mechanisms of endoplasmic reticulum stress to increase susceptibility of cancer cells to fenretinide-induced apoptosis: the role of stress proteins ERdj5 and ERp57.
Neuroectodermal Tumors, Primitive
PI3K/Akt/mTOR pathway inhibitors in the therapy of pancreatic neuroendocrine tumors.
Neuroendocrine Tumors
177Lu-octreotate therapy for neuroendocrine tumours is enhanced by Hsp90 inhibition.
18F-Radiolabeling and Preliminary Evaluation of a HSP90 ligand.
Expression profiling of small intestinal neuroendocrine tumors identifies subgroups with clinical relevance, prognostic markers and therapeutic targets.
Heat shock protein 90 is a promising target for effective growth inhibition of gastrointestinal neuroendocrine tumors.
HSP90 expression and early recurrence in gastroenteropancreatic neuroendocrine tumors: Potential for a novel therapeutic target.
Neuroendocrine tumors of the gastrointestinal tract: recent advances in molecular genetics, diagnosis, and treatment.
Potent antitumor activity of the novel HSP90 inhibitors AUY922 and HSP990 in neuroendocrine carcinoid cells.
The HSP90 inhibitor onalespib potentiates 177Lu?DOTATATE therapy in neuroendocrine tumor cells.
Neurofibromatoses
Therapeutic potential of HSP90 inhibition for neurofibromatosis type 2.
Neurofibromatosis 2
Combining curcumin (diferuloylmethane) and heat shock protein inhibition for neurofibromatosis 2 treatment: analysis of response and resistance pathways.
Therapeutic potential of HSP90 inhibition for neurofibromatosis type 2.
Neurofibrosarcoma
Expression of HSP90 in gastrointestinal stromal tumours and mesenchymal tumours.
Targeting Refractory Sarcomas and Malignant Peripheral Nerve Sheath Tumors in a Phase I/II Study of Sirolimus in Combination with Ganetespib (SARC023).
Neuroinflammatory Diseases
?B-Crystallin regulates expansion of CD11b?Gr-1? immature myeloid cells during tumor progression.
Characterization of migration parameters on peripheral and central nervous system T cells following treatment of experimental allergic encephalomyelitis with CRYAB.
Current and emerging therapeutic targets for Parkinson's disease.
Heat shock protein 70 suppresses neuroinflammation induced by ?-synuclein in astrocytes.
Highly Selective Activation of Heat Shock Protein 70 by Allosteric Regulation Provides an Insight into Efficient Neuroinflammation Inhibition.
Histamine Is an Inducer of the Heat Shock Response in SOD1-G93A Models of ALS.
Inhibition of heat shock protein family A member 8 attenuates spinal cord ischemia-reperfusion injury via astrocyte NF-?B/NLRP3 inflammasome pathway : HSPA8 inhibition protects spinal ischemia-reperfusion injury.
Luteolin alleviates cognitive impairment in Alzheimer's disease mouse model via inhibiting endoplasmic reticulum stress-dependent neuroinflammation.
Microglial LOX-1 reacts with extracellular HSP60 to bridge neuroinflammation and neurotoxicity.
Mitogen-activated protein kinase-activated protein kinase 2 in neuroinflammation, heat shock protein 27 phosphorylation, and cell cycle: role and targeting.
Molecular chaperone alpha-crystallin prevents detrimental effects of neuroinflammation.
Novel role of mortalin in attenuating HIV-1 Tat-mediated astrogliosis.
Peripherally misfolded proteins exacerbate ischemic stroke-induced neuroinflammation and brain injury.
Role of Mitochondrial Stress Protein HSP60 in Diabetes-Induced Neuroinflammation.
Surgery-induced cognitive dysfunction is alleviated through triggering receptor expressed on myeloid cells 2.
The anti-inflammatory and antiapoptotic effects of probiotic on induced neurotoxicity in juvenile hamsters.
The impact of postsynaptic density 95 blocking peptide (Tat-NR2B9c) and an iNOS inhibitor (1400W) on proteomic profile of the hippocampus in C57BL/6J mouse model of kainate-induced epileptogenesis.
Therapeutic Intervention in Multiple Sclerosis with Alpha B-Crystallin: A Randomized Controlled Phase IIa Trial.
Neurologic Manifestations
Correlation of lymphocyte heat shock protein 70 levels with neurologic deficits in elderly patients with cerebral infarction.
Neuromuscular Diseases
Autophagy in neurodegeneration: New insights underpinning therapy for neurological diseases.
MitCHAP-60 and Hereditary Spastic Paraplegia SPG-13 Arise from an Inactive hsp60 Chaperonin that Fails to Fold the ATP Synthase ?-Subunit.
Novel insights in the disease biology of mutant small heat shock proteins in neuromuscular diseases.
Structures of TorsinA and its disease-mutant complexed with an activator reveal the molecular basis for primary dystonia.
Neuromyelitis Optica
GRP78 antibodies damage the blood-brain barrier and relate to cerebellar degeneration in Lambert-Eaton myasthenic syndrome.
GRP78 autoantibodies initiate the breakdown of the blood-brain barrier in neuromyelitis optica.
Neutropenia
Epidemiology, genetic variants and clinical course of natural infections with Anaplasma phagocytophilum in a dairy cattle herd.
Nevus
HSP90 as a marker of progression in melanoma.
Prognostic implications of markers of the metabolic phenotype in human cutaneous melanoma.
Nevus, Pigmented
Expression of heat shock protein 105 and 70 in malignant melanoma and benign melanocytic nevi.
Expression of the heat shock cognate protein HSP73 correlates with tumour thickness of primary melanomas and is enhanced in melanoma metastases.
Induction of Hsp90 protein expression in malignant melanomas and melanoma metastases.
Newcastle Disease
Autophagy in farm animals: current knowledge and future challenges.
Niemann-Pick Disease, Type C
Heat Shock Protein Beta-1 Modifies Anterior to Posterior Purkinje Cell Vulnerability in a Mouse Model of Niemann-Pick Type C Disease.
Niemann-Pick Diseases
Relationship between HSP90a, NPC2 and L-PGDS proteins to boar semen freezability.
Nocardia Infections
Comparison of protective efficacy between two DNA vaccines encoding DnaK and GroEL against fish nocardiosis.
Non-alcoholic Fatty Liver Disease
Circulating Hsp90 Isoform Levels in Overweight and Obese Children and the Relation to Nonalcoholic Fatty Liver Disease: Results from a Cross-Sectional Study.
Glucose regulated protein 78 is potentially an important player in the development of nonalcoholic steatohepatitis.
Heat Shock Protein 27 is down-regulated in Ballooned Hepatocytes of Patients with Nonalcoholic Steatohepatitis (NASH).
Hsp90 modulates PPAR? activity in a mouse model of nonalcoholic fatty liver disease.
Investigating Molecular Connections of Non-alcoholic Fatty Liver Disease with Associated Pathological Conditions in West Virginia for Biomarker Analysis.
Loss and gain of function of Grp75 or mitofusin 2 distinctly alter cholesterol metabolism, but all promote triglyceride accumulation in hepatocytes.
Serum Fragmented Cytokeratin 18 Levels Reflect the Histologic Activity Score of Nonalcoholic Fatty Liver Disease More Accurately Than Serum Alanine Aminotransferase Levels.
Silymarin attenuated nonalcoholic fatty liver disease through the regulation of endoplasmic reticulum stress proteins GRP78 and XBP-1 in mice.
The ménage à trois of autophagy, lipid droplets and liver disease.
[Effects of electroacupuncture combined with dietary control on liver endoplasmic reticulum stress in rats with non-alcoholic fatty liver disease].
non-chaperonin molecular chaperone atpase deficiency
A Cell Model for HSP60 Deficiencies: Modeling Different Levels of Chaperonopathies Leading to Oxidative Stress and Mitochondrial Dysfunction.
A cell model to study different degrees of Hsp60 deficiency in HEK293 cells.
A new case of multiple mitochondrial enzyme deficiencies with decreased amount of heat shock protein 60.
Chaperonin 60 regulation of SOX9 ubiquitination mitigates the development of knee osteoarthritis.
Constitutive heat shock protein 70 interacts with ?-enolase and protects cardiomyocytes against oxidative stress.
Decreased synthesis and inefficient mitochondrial import of hsp60 in a patient with a mitochondrial encephalomyopathy.
GRP78 effectively protect hypoxia/reperfusion-induced myocardial apoptosis via promotion of the Nrf2/HO-1 signaling pathway.
Hsp104 disaggregase at normal levels cures many [PSI(+)] prion variants in a process promoted by Sti1p, Hsp90, and Sis1p.
Intracellular Heat Shock Protein 70 Deficiency in Pulmonary Fibrosis.
Molecular chaperone disorders: defective hsp60 in neurodegeneration.
Mortalin deficiency suppresses fibrosis and induces apoptosis in keloid spheroids.
Overexpression of Hsc70 promotes proliferation, migration, and invasion of human glioma cells.
[Mechanism of heat shock protein 90 for regulating 26S proteasome in hyperthermia].
Obesity
17-DMAG, an Hsp90 inhibitor, ameliorates ovariectomy-induced obesity in rats.
Adipocytes from new zealand obese mice exhibit aberrant proinflammatory reactivity to the stress signal heat shock protein 60.
An acylic polyisoprenoid derivative, geranylgeranylacetone protects against visceral adiposity and insulin resistance in high-fat-fed mice.
Association of extracellular heat shock protein 70 and insulin resistance in type 2 diabetes; independent of obesity and C-reactive protein.
Association of heat shock protein70-2 (HSP70-2) gene polymorphism with obesity.
Autoimmunity to HSP60 during diet induced obesity in mice.
Commensal Hafnia alvei strain reduces food intake and fat mass in obese mice-a new potential probiotic for appetite and body weight management.
Daily rhythm and heat shock protein expression in obese ob/ob mice.
Effects of in vitro heat shock on immune cells in diet-induced obese mice.
Endoplasmic reticulum chaperone GRP78 regulates macrophage function and insulin resistance in diet-induced obesity.
Excessive endoplasmic reticulum stress and decreased neuroplasticity-associated proteins in prefrontal cortex of obese rats and the regulatory effects of aerobic exercise.
Genetic Targeting of GRP78 in the VMH Improves Obesity Independently of Food Intake.
Genetic variation in the stress protein hsp70-2 gene is highly associated with obesity.
Glucolipotoxicity diminishes cardiomyocyte TFEB and inhibits lysosomal autophagy during obesity and diabetes.
Grp78 Heterozygosity Promotes Adaptive Unfolded Protein Response and Attenuates Diet-Induced Obesity and Insulin Resistance.
GRP78 levels, regional fat distribution and endometrial cáncer.
Heat shock protein 60 and adipocytes: characterization of a ligand-receptor interaction.
Heat Shock Protein 90 Alpha, Lass B Member 1: a Key Regulative Gene of Monitoring Duodenal Tumor for Obesity Induced by High-Fat Diet.
Heat shock proteins in obesity: links to cardiovascular disease.
High-fat diet-induced obesity amplifies HSP70-2a and HSP90 expression in testicular tissue; correlation with proliferating cell nuclear antigen (PCNA).
HSP60 reduction protects against diet-induced obesity by modulating energy metabolism in adipose tissue.
HSP72 is a Mitochondrial Stress Sensor Critical for Parkin Action, Oxidative Metabolism, and Insulin Sensitivity in Skeletal Muscle.
Hsp90 blockers inhibit adipocyte differentiation and fat mass accumulation.
Hsp90 chaperones PPAR? and regulates differentiation and survival of 3T3-L1 adipocytes.
Leptin induced GRP78 expression through the PI3K-mTOR pathway in neuronal cells.
Loss and gain of function of Grp75 or mitofusin 2 distinctly alter cholesterol metabolism, but all promote triglyceride accumulation in hepatocytes.
MC4R Variant rs17782313 Associates With Increased Levels of DNAJC27, Ghrelin, and Visfatin and Correlates With Obesity and Hypertension in a Kuwaiti Cohort.
Modification of lung endoplasmic reticulum genes expression and NF-kB protein levels in obese ovalbumin-sensitized male and female rats.
Obesity: Hsp60 integrates central crosstalk.
Physical exercise alleviates ER stress in obese humans through reduction in the expression and release of GRP78 chaperone.
Physical Exercise Enhanced Heat Shock Protein 60 Expression and Attenuated Inflammation in the Adipose Tissue of Human Diabetic Obese.
Polymorphism of stress protein HSP70-2 gene in Tunisians: susceptibility implications in type 2 diabetes and obesity.
Proteomic Analysis for Antiobesity Potential of Capsaicin on White Adipose Tissue in Rats Fed with a High Fat Diet.
Proteomic analysis of primary cultures of human adipose-derived stem cells: modulation by Adipogenesis.
Radicicol, a heat shock protein 90 inhibitor, inhibits differentiation and adipogenesis in 3T3-L1 preadipocytes.
Reduction of Hypothalamic ER Stress Activates Browning of White Fat and Ameliorates Obesity.
Relationship Between Heat Shock Protein Expression and Obesity With and Without Metabolic Syndrome.
The Drosophila ETV5 Homologue Ets96B: Molecular Link between Obesity and Bipolar Disorder.
Tissue cell stress response to obesity and its interaction with late gestation diet.
Obesity, Morbid
Heat Shock Protein 60 in Obesity: Effect of Bariatric Surgery and its Relation to Inflammation and Cardiovascular Risk.
Obstetric Labor, Premature
Endoplasmic reticulum stress is increased after spontaneous labor in human fetal membranes and myometrium where it regulates the expression of prolabor mediators.
Ocular Hypertension
Heat shock proteins in the retina: focus on HSP70 and alpha crystallins in ganglion cell survival.
Oligodendroglioma
GRP78 is overexpressed in glioblastomas and regulates glioma cell growth and apoptosis.
Heat shock protein expression in human gliomas.
Oligospermia
Heat shock protein and heat shock factor expression in sperm: relation to oligozoospermia and varicocele.
Onchocerciasis
Fine specificity of autoantibodies to calreticulin: epitope mapping and characterization.
Oncogene Addiction
D-Propranolol Impairs EGFR Trafficking and Destabilizes Mutant p53 Counteracting AKT Signaling and Tumor Malignancy.
Drugging the cancer chaperone HSP90: combinatorial therapeutic exploitation of oncogene addiction and tumor stress.
Heat shock protein 90 inhibitors in the treatment of cancer: current status and future directions.
Optical Imaging of Treatment-Related Tumor Cell Death Using a Heat Shock Protein-90 Alkylator.
SMYD2-dependent HSP90 methylation promotes cancer cell proliferation by regulating the chaperone complex formation.
Sulphoxythiocarbamates modify cysteine residues in HSP90 causing degradation of client proteins and inhibition of cancer cell proliferation.
Optic Atrophy
Mitochondrial serine protease Omi/HtrA2 accentuates brain ischemia/reperfusion injury in rats and oxidative stress injury in vitro by modulating mitochondrial stress proteins CHOP and ClpP and physically interacting with mitochondrial fusion protein OPA1.
Optic Atrophy, Autosomal Dominant
Proteasome dysfunction induces excessive proteome instability and loss of mitostasis that can be mitigated by enhancing mitochondrial fusion or autophagy.
Optic Nerve Diseases
Anti-Ro/SS-A positivity and heat shock protein antibodies in patients with normal-pressure glaucoma.
Optic Nerve Injuries
Heat shock protein 72 confers protection in retinal ganglion cells and lateral geniculate nucleus neurons via blockade of the SAPK/JNK pathway in a chronic ocular-hypertensive rat model.
Induction and phosphorylation of the small heat shock proteins HspB1/Hsp25 and HspB5/?B-crystallin in the rat retina upon optic nerve injury.
Oral Submucous Fibrosis
Expression of heat shock protein70 in oral submucous fibrosis and oral squamous cell carcinoma: an immunohistochemical study.
In-silico analysis of heat shock protein 47 for identifying the novel therapeutic agents in the management of oral submucous fibrosis.
Oral Ulcer
Association between the 65-kilodalton heat shock protein, Streptococcus sanguis, and the corresponding antibodies in Behçet's syndrome.
Recognition of a unique peptide epitope of the mycobacterial and human heat shock protein 65-60 antigen by T cells of patients with recurrent oral ulcers.
Osteitis Deformans
Transgenic expression of inclusion body myopathy associated mutant p97/VCP causes weakness and ubiquitinated protein inclusions in mice.
Osteoarthritis
A novel pathogenic role of the ER chaperone GRP78/BiP in rheumatoid arthritis.
Advanced osteoarthritis in humans is associated with altered collagen VI expression and upregulation of ER-stress markers Grp78 and bag-1.
Analysis of 70Kd heat shock protein expression in patients with internal derangement of the temporomandibular joint.
Combined microwave irradiation and intraarticular glutamine administration-induced HSP70 expression therapy prevents cartilage degradation in a rat osteoarthritis model.
Effects of laser irradiation on arthritic histopathology and heat shock protein 70 expression in C57 black mice with osteoarthritis.
Heat shock protein gene expression profile may differentiate between rheumatoid arthritis, osteoarthritis, and healthy controls.
Hsp90 inhibition protects against biomechanically induced osteoarthritis in rats.
Hsp90 mediates insulin-like growth factor 1 and interleukin-1beta signaling in an age-dependent manner in equine articular chondrocytes.
Hyaluronate on heat shock protein and synovial cells in a canine model of osteoarthritis.
Local induction of heat shock protein 70 (Hsp70) by proteasome inhibition confers chondroprotection during surgically induced osteoarthritis in the rat knee.
MTORC1 coordinates the autophagy and apoptosis signaling in articular chondrocytes in osteoarthritic temporomandibular joint.
RNA-binding protein ZFP36L1 regulates osteoarthritis by modulating members of the heat shock protein 70 family.
Upregulation of 78-kDa glucose-regulated protein in macrophages in peripheral joints of active ankylosing spondylitis.
Osteoarthritis, Hip
[Heat shock protein antibodies and other chlamydial antigens in various diseases and their occurrence in blood donors]
Osteoarthritis, Knee
Chaperonin 60 regulation of SOX9 ubiquitination mitigates the development of knee osteoarthritis.
Circulating and Synovial Fluid Heat Shock Protein 70 Are Correlated with Severity in Knee Osteoarthritis.
Osteochondritis Dissecans
Autophagy in farm animals: current knowledge and future challenges.
Osteochondrodysplasias
Clinical efficiency and safety of Hsp90 inhibitor Novobiocin in avian tibial dyschondroplasia.
Hsp90 inhibitor celastrol reinstates growth plate angiogenesis in thiram-induced tibial dyschondroplasia.
In Vitro Effect of Apigenin and Danshen in Tibial Dyschondroplasia Through Inhibition of Heat-Shock Protein 90 and Vascular Endothelial Growth Factor Expressions in Avian Growth Plate Cells.
Recovery of Chicken Growth Plate by Heat-Shock Protein 90 Inhibitors Epigallocatechin-3-Gallate and Apigenin in Thiram-Induced Tibial Dyschondroplasia.
Osteogenesis Imperfecta
Endoplasmic reticulum-mediated quality control of type I collagen production by cells from osteogenesis imperfecta patients with mutations in the pro alpha 1 (I) chain carboxyl-terminal propeptide which impair subunit assembly.
Mutants of collagen-specific molecular chaperone Hsp47 causing osteogenesis imperfecta are structurally unstable with weak binding affinity to collagen.
Osteolysis
The Escherichia coli chaperonin 60 (groEL) is a potent stimulator of osteoclast formation.
The heat shock protein 90 inhibitor, 17-allylamino-17-demethoxygeldanamycin, enhances osteoclast formation and potentiates bone metastasis of a human breast cancer cell line.
[Effect of oxidative stress on periprosthetic osteolysis induced by TCP wear particles in mouse calvaria and its mechanism].
[Validity of the Morawietz classification for evaluation of periprosthetic tissue].
Osteophyte
Chaperonin 60 regulation of SOX9 ubiquitination mitigates the development of knee osteoarthritis.
Osteoporosis
Autoreactivity to glucose regulated protein 78 links emphysema and osteoporosis in smokers.
Heat shock protein 90 is required for increased DNA binding activity of activator protein-1, a heterodimer of Fos/JunD, in rheumatoid synovial cells under inflammatory stimuli.
Hsp60 and human aging: Les liaisons dangereuses.
Inhibitors of heat shock protein 90 augment endothelin?1?induced heat shock protein 27 through the SAPK/JNK signaling pathway in osteoblasts.
Osteoblastic cell secretome: a novel role for progranulin during risedronate treatment.
Regulation of ER molecular chaperone prevents bone loss in a murine model for osteoporosis.
Serum levels of phosphorylated heat shock protein 27 (pHSP27) are associated with bone mineral density in pre- & postmenopausal women: A pilot study.
Specific induction of heat shock protein 27 by glucocorticoid in osteoblasts.
Osteosarcoma
17-AAG and Apoptosis, Autophagy, and Mitophagy in Canine Osteosarcoma Cell Lines.
A correlation analysis between tumor imaging changes and p-AKT and HSP70 expression in tumor cells after osteosarcoma chemotherapy.
A new antisarcoma strategy: multisubtype heat shock protein/peptide immunotherapy combined with PD-L1 immunological checkpoint inhibitors.
AHA1 upregulates IDH1 and metabolic activity to promote growth and metastasis and predicts prognosis in osteosarcoma.
Analysis of HSP27 and the autophagy marker LC3B+ puncta following preoperative chemotherapy identifies high-risk osteosarcoma patients.
Anesthesia for euthanasia influences mRNA expression in healthy mice and after traumatic brain injury.
Antibodies to heat shock protein 90 in osteosarcoma patients correlate with response to neoadjuvant chemotherapy.
Apoptosis of osteosarcoma cultures by the combination of the cyclin-dependent kinase inhibitor SCH727965 and a heat shock protein 90 inhibitor.
ATF4 destabilizes RET through nonclassical GRP78 inhibition to enhance chemosensitivity to bortezomib in human osteosarcoma.
Blocking HSP90 Addiction Inhibits Tumor Cell Proliferation, Metastasis Development, and Synergistically Acts with Zoledronic Acid to Delay Osteosarcoma Progression.
Coffee intake mitigated inflammation and obesity-induced insulin resistance in skeletal muscle of high-fat diet-induced obese mice.
Combining GRP78 suppression and MK2206-induced Akt inhibition decreases doxorubicin-induced P-glycoprotein expression and mitigates chemoresistance in human osteosarcoma.
Critical role of heat shock protein 27 in bufalin-induced apoptosis in human osteosarcomas: a proteomic-based research.
Design and synthesis of pyrimidinyl acyl thioureas as novel Hsp90 inhibitors in invasive ductal breast cancer and its bone metastasis.
Distinct profiles of oxidative stress-related and matrix proteins in adult bone and soft tissue osteosarcoma and desmoid tumors: A proteomics study.
Effects of Ezrin and Heat Shock Protein 70 on Apoptosis and Proliferation of Human Osteosarcoma Cells.
Effects of hyperthermia on heat shock protein expression, alkaline phosphatase activity and proliferation in human osteosarcoma cells.
Experimental study of inhibitory effects of diallyl trisulfide on the growth of human osteosarcoma Saos-2 cells by downregulating expression of glucose-regulated protein 78.
Exposure of Wistar rats to 24-h psycho-social stress alters gene expression in the inferior colliculus.
Expression and its clinical significance of heat shock protein gp96 in human osteosarcoma.
Expression and significance of glucose-regulated protein 78 in human osteosarcoma.
Expression of heat shock proteins in osteosarcomas.
Extracellular heat shock protein HSP90beta secreted by MG63 osteosarcoma cells inhibits activation of latent TGF-beta1.
Genetic response to low?intensity ultrasound on mouse ST2 bone marrow stromal cells.
GRP78 inhibition enhances ATF4-induced cell death by the deubiquitination and stabilization of CHOP in human osteosarcoma.
Heat shock protein 72 expression in osteosarcomas correlates with good response to neoadjuvant chemotherapy.
Heat shock protein 90B1 plays an oncogenic role and is a target of microRNA-223 in human osteosarcoma.
Heat shock protein expression analysis in canine osteosarcoma reveals HSP60 as a potentially relevant therapeutic target.
Heat shock protein expression in canine osteosarcoma.
Hsp90 inhibitor 17?AAG inhibits stem cell?like properties and chemoresistance in osteosarcoma cells via the Hedgehog signaling pathway.
Hsp90 inhibitor induces autophagy and apoptosis in osteosarcoma cells.
Hsp90 inhibitors deplete key anti-apoptotic proteins in pediatric solid tumor cells and demonstrate synergistic anticancer activity with cisplatin.
HSP90 regulates osteosarcoma cell apoptosis by targeting the p53/TCF-1-mediated transcriptional network.
Hyperthermia reduces migration of osteosarcoma by suppression of autocrine motility factor.
Influence of ezrin-shRNA in combination with HSP70 on the apoptosis and proliferation of osteosarcoma cells.
Investigation of anticancer activities of STA-9090 (ganetespib) as a second generation HSP90 inhibitor in Saos-2 osteosarcoma cells.
Kuanoniamine C stimulates bortezomib-induced cell death via suppression of glucose-regulated protein 78 in osteosarcoma.
microRNA-338-3p inhibits proliferation, migration, invasion, and EMT in osteosarcoma cells by targeting activator of 90 kDa heat shock protein ATPase homolog 1.
Mild microwave ablation combined with HSP90 and TGF??1 inhibitors enhances the therapeutic effect on osteosarcoma.
miR-485-5p/HSP90 axis blocks Akt1 phosphorylation to suppress osteosarcoma cell proliferation and migration via PI3K/AKT pathway.
Novel findings in gene expression detected in human osteosarcoma by cDNA microarray.
OS-9 facilitates turnover of nonnative GRP94 marked by hyperglycosylation.
Overexpression of resistance-related proteins (metallothioneins, glutathione-S-transferase pi, heat shock protein 27, and lung resistance-related protein) in osteosarcoma. Relationship with poor prognosis.
Phosphorylated heat shock protein 27 as a potential biomarker to predict the role of chemotherapy-induced autophagy in osteosarcoma response to therapy.
Photodynamic therapy reduces the inhibitory effect of osteosarcoma cells on dendritic cells by upregulating HSP70.
Pigment epithelium-derived factor upregulates collagen I and downregulates matrix metalloproteinase 2 in osteosarcoma cells, and colocalises to collagen I and heat shock protein 47 in fetal and adult bone.
Polydatin enhances the chemosensitivity of osteosarcoma cells to paclitaxel.
Protein profiling of osteosarcoma tissue and soft callus unveils activation of the unfolded protein response pathway.
Rab22a-NeoF1 fusion protein promotes osteosarcoma lung metastasis through its secretion into exosomes.
Serum antibodies against the heat shock protein 60 are elevated in patients with osteosarcoma.
Spontaneous and controllable activation of suicide gene expression driven by the stress-inducible grp78 promoter resulting in eradication of sizable human tumors.
Structural studies of UBXN2A and mortalin interaction and the putative role of silenced UBXN2A in preventing response to chemotherapy.
Suppression of heat shock protein 70 by siRNA enhances the antitumor effects of cisplatin in cultured human osteosarcoma cells.
Synergistic activity of Hsp90 inhibitors and anticancer agents in pancreatic cancer cell cultures.
Syntenic conservation of HSP70 genes in cattle and humans.
Targeted therapy of human osteosarcoma with 17AAG or rapamycin: characterization of induced apoptosis and inhibition of mTOR and Akt/MAPK/Wnt pathways.
Targeting GRP78 enhances the sensitivity of HOS osteosarcoma cells to pyropheophorbide-? methyl ester-mediated photodynamic therapy via the Wnt/?-catenin signaling pathway.
Targeting HSP70 and GRP78 in canine osteosarcoma cells in combination with doxorubicin chemotherapy.
The effects of MEX3A knockdown on proliferation, apoptosis and migration of osteosarcoma cells.
The HSP90 inhibitor alvespimycin enhances the potency of telomerase inhibition by imetelstat in human osteosarcoma.
The Major Heat Shock Proteins, Hsp70 and Hsp90, in 2-Methoxyestradiol-Mediated Osteosarcoma Cell Death Model.
The novel HSP90 inhibitor STA-1474 exhibits biologic activity against osteosarcoma cell lines.
Transcriptional regulation of Runx2 by HSP90 controls osteosarcoma apoptosis via the AKT/GSK-3?/?-catenin signaling.
Tumor necrosis factor-associated protein 1 (TRAP-1) protects cells from oxidative stress and apoptosis.
Upregulation of Glucose-Regulated Protein 78 in Metastatic Cancer Cells Is Necessary for Lung Metastasis Progression.
Vorinostat suppresses hypoxia signaling by modulating nuclear translocation of hypoxia inducible factor 1 alpha.
Otitis Media
Expression of HSP70 and Its Relation with Other Cytokines in Human Middle Ear Effusion.
Otitis Media with Effusion
Expression of HSP70 and Its Relation with Other Cytokines in Human Middle Ear Effusion.
Ototoxicity
Celastrol inhibits aminoglycoside-induced ototoxicity via heat shock protein 32.
Expression of heat shock protein 72 in rat cochlea with cisplatin-induced acute ototoxicity.
Geldanamycin induces production of heat shock protein 70 and partially attenuates ototoxicity caused by gentamicin in the organ of Corti explants.
Heat shock protein 70 and cellular disturbances in cochlear cisplatin ototoxicity model.
Heat shock protein 70 delays gentamicin-induced vestibular hair cell death.
Role of Hsp90/Akt pathway in the pathogenesis of gentamicin-induced hearing loss.
[Expression of heat shock protein 70 mRNA in guinea pig cochlea with ototoxicity of gentamicin]
[Heat shock response in guinea pigs cochlea with gentamicin ototoxicity].
Ovarian Cysts
Expression of the 60 kDa heat shock protein in peritoneal fluids from women with endometriosis: implications for endometriosis-associated infertility.
Heat Shock Protein 70 and Sex Steroid Receptors in the Follicular Structures of Induced Ovarian Cysts.
Unfolded protein response, a link between endometrioid ovarian carcinoma and endometriosis: A pilot study.
Ovarian Diseases
Heat Shock Protein 70 and Sex Steroid Receptors in the Follicular Structures of Induced Ovarian Cysts.
Heat shock protein patterns in the bovine ovary and relation with cystic ovarian disease.
Ovarian Neoplasms
18?-Glycyrrhetinic acid potentiates Hsp90 inhibition-induced apoptosis in human epithelial ovarian carcinoma cells via activation of death receptor and mitochondrial pathway.
A novel mycobacterial Hsp70-containing fusion protein targeting mesothelin augments antitumor immunity and prolongs survival in murine models of ovarian cancer and mesothelioma.
A Transcriptionally Definable Subgroup of Triple-Negative Breast and Ovarian Cancer Samples Shows Sensitivity to HSP90 Inhibition.
An aptamer interacting with heat shock protein 70 shows therapeutic effects and prognostic ability in serous ovarian cancer.
An HSP90-mimic peptide revealed by fingerprinting the pool of antibodies from ovarian cancer patients.
An in vitro and in vivo study of the combination of the heat shock protein inhibitor 17-allylamino-17-demethoxygeldanamycin and carboplatin in human ovarian cancer models.
Anti-KDEL-coated nanoparticles: A promising tumor targeting approach for ovarian cancer?
Antibodies against Hsp60 and Hsp65 in the sera of women with ovarian cancer.
Autoantibodies against cell surface GRP78 promote tumor growth in a murine model of melanoma.
BAG-4/SODD and associated antiapoptotic proteins are linked to aggressiveness of epithelial ovarian cancer.
CAF-derived HGF promotes cell proliferation and drug resistance by up-regulating the c-Met/PI3K/Akt and GRP78 signaling in ovarian cancer cells.
Cancer immunotherapy using irradiated tumor cells secreting heat shock protein 70.
Change in the localization of heat shock protein 27 (HSP 27) in BG-1 human ovarian cancer cells following treatment by the ether lipid ET-18-OCH3.
Circulating GRP78 antibodies from ovarian cancer patients: a promising tool for cancer cell targeting drug delivery system?
Cisplatin-induced senescence in ovarian cancer cells is mediated by GRP78.
Correction to: An in vitro and in vivo study of the combination of the heat shock protein inhibitor 17-allylamino-17-demethoxygeldanamycin and carboplatin in human ovarian cancer models.
Correction: Strong antitumor synergy between DNA crosslinking and HSP90 inhibition causes massive premitotic DNA fragmentation in ovarian cancer cells.
Design and encapsulation of anticancer dual HSP27 and HER2 inhibitor into low density lipoprotein to target ovarian cancer cells.
Developing a genetic signature to predict drug response in ovarian cancer.
Drug-induced Modulation of Heat Shock Protein HSPB1 in an Ovarian Cancer Cell Model.
ErbB2 overexpression in an ovarian cancer cell line confers sensitivity to the HSP90 inhibitor geldanamycin.
Erratum: Heat shock protein 70-2 (HSP70-2) a novel cancer testis antigen that promotes growth of ovarian cancer.
Expression and clinical role of antiapoptotic proteins of the bag, heat shock, and Bcl-2 families in effusions, primary tumors, and solid metastases in ovarian carcinoma.
Expression and localization of GRP75 in human epithelial tumors and normal tissues.
Expression of heat shock protein 20 inversely correlated with tumor progression in patients with ovarian cancer.
Expression of the heat shock protein HSP27 in human ovarian cancer.
Geldanamycin, an inhibitor of Hsp90, increases paclitaxel-mediated toxicity in ovarian cancer cells through sustained activation of the p38/H2AX axis.
Gene and protein expression profiling of human ovarian cancer cells treated with the heat shock protein 90 inhibitor 17-allylamino-17-demethoxygeldanamycin.
GRP75 modulates oncogenic Dbl-driven endocytosis derailed via the CHIP-mediated ubiquitin degradation pathway.
GRP78 knockdown does not affect cytotoxicity of cisplatin in ovarian cancer cells.
GRP78 Protein Expression in Ovarian Cancer Patients and Perspectives for a Drug-Targeting Approach.
Heat shock protein 27 (hsp27) in patients with ovarian cancer.
Heat Shock Protein 60 (HSP60) Serves as a Potential Target for the Sensitization of Chemoresistant Ovarian Cancer Cells.
Heat shock protein 70-2 (HSP70-2) a novel cancer testis antigen that promotes growth of ovarian cancer.
Heat Shock Protein 90 Triggers Multi-Drug Resistance of Ovarian Cancer via AKT/GSK3?/?-Catenin Signaling.
Heat Shock Protein HSP27 Secretion by Ovarian Cancer Cells Is Linked to Intracellular Expression Levels, Occurs Independently of the Endoplasmic Reticulum Pathway and HSP27's Phosphorylation Status, and Is Mediated by Exosome Liberation.
Heat shock proteins, cell survival and drug resistance: the mitochondrial chaperone TRAP1, a potential novel target for ovarian cancer therapy.
High-resolution mapping of genomic imbalance and identification of gene expression profiles associated with differential chemotherapy response in serous epithelial ovarian cancer.
HSP27 is required for invasion and metastasis triggered by hepatocyte growth factor.
HSP60 Predicts Survival in Advanced Serous Ovarian Cancer.
HSP70 inhibition synergistically enhances the effects of magnetic fluid hyperthermia in ovarian cancer.
HSP90 identified by a proteomic approach as druggable target to reverse platinum resistance in ovarian cancer.
Hsp90 inhibitor geldanamycin enhances the antitumor efficacy of enediyne lidamycin in association with reduced DNA damage repair.
Hsp90 inhibitor SY-016 induces G2/M arrest and apoptosis in paclitaxel-resistant human ovarian cancer cells.
Hsp90 Is a Novel Target Molecule of CDDO-Me in Inhibiting Proliferation of Ovarian Cancer Cells.
Identification of heat shock protein 90 and other proteins as tumour antigens by serological screening of an ovarian carcinoma expression library.
IgA antibodies to the 27-kDa heat-shock protein in the genital tracts of women with gynecologic cancers.
Immunohistochemical detection of HSP60-expression in human ovarian cancer. Correlation with survival in a series of 247 patients.
Increased expression of heat shock protein 70 in adherent ovarian cancer and mesothelioma following treatment with manumycin, a farnesyl transferase inhibitor.
Increased temperature-related adeno-associated virus vectors transduction of ovarian cancer cells - essential signatures of AAV receptor and heat shock proteins.
Inhibition of mortalin expression reverses cisplatin resistance and attenuates growth of ovarian cancer cells.
Insight into residues involved in the structure and function of the breast cancer associated protein human gamma synuclein.
Involvement of GRP78 in the Resistance of Ovarian Carcinoma Cells to Paclitaxel.
Lamin-A interacting protein Hsp90 is required for DNA damage repair and chemoresistance of ovarian cancer cells.
Metabolic markers and HSP60 in chemonaive serous solid ovarian cancer versus ascites.
Mifepristone increases mRNA translation rate, triggers the unfolded protein response, increases autophagic flux, and kills ovarian cancer cells in combination with proteasome or lysosome inhibitors.
MiR-181c sensitizes ovarian cancer cells to paclitaxel by targeting GRP78 through the PI3K/Akt pathway.
New agents for the treatment of ovarian cancer: the next generation.
NF-?B p65 promotes ovarian cancer cell proliferation and migration via regulating mortalin.
Novel ovarian cancer maintenance therapy targeted at mortalin and mutant p53.
Oncogenic role of mortalin contributes to ovarian tumorigenesis by activating the MAPK-ERK pathway.
Osmotic and heat stress-dependent regulation of MLK4? and MLK3 by the CHIP E3 ligase in ovarian cancer cells.
Part I of GANNET53: A European Multicenter Phase I/II Trial of the Hsp90 Inhibitor Ganetespib Combined With Weekly Paclitaxel in Women With High-Grade, Platinum-Resistant Epithelial Ovarian Cancer-A Study of the GANNET53 Consortium.
Patient-derived tumor-reactive antibodies as diagnostic markers for ovarian cancer.
Pharmacokinetic-pharmacodynamic relationships for the heat shock protein 90 molecular chaperone inhibitor 17-allylamino, 17-demethoxygeldanamycin in human ovarian cancer xenograft models.
Priming with HDAC Inhibitors Sensitizes Ovarian Cancer Cells to Treatment with Cisplatin and HSP90 Inhibitors.
Profiling Hsp90 differential expression and the molecular effects of the Hsp90 inhibitor IPI-504 in high-grade glioma models.
Progression of the role of CRYAB in signaling pathways and cancers.
Purified autoantibodies against glucose-regulated protein 78 (GRP78) promote apoptosis and decrease invasiveness of ovarian cancer cells.
Regulation by heat shock protein 22 (HSPB8) of transforming growth factor-?-induced ovary cancer cell migration.
Relationship between heat shock protein 60 (HSP60) mRNA expression and resistance to platinum analogues in human ovarian and bladder carcinoma cell lines.
Reversing drug resistance of cisplatin by hsp90 inhibitors in human ovarian cancer cells.
Role of PAR-4 in ovarian cancer.
Secretion of cytokines and heat shock protein (HspA1A) by ovarian cancer cells depending on the tumor type and stage of disease.
Serologic evidence of past infection with Chlamydia trachomatis, in relation to ovarian cancer.
Small interfering RNA-mediated silencing of heat shock protein 27 (HSP27) Increases chemosensitivity to paclitaxel by increasing production of reactive oxygen species in human ovarian cancer cells (HO8910).
Stress-Adaptive Response in Ovarian Cancer Drug Resistance: Role of TRAP1 in Oxidative Metabolism-Driven Inflammation.
Strong antitumor synergy between DNA crosslinking and HSP90 inhibition causes massive premitotic DNA fragmentation in ovarian cancer cells.
Syngeneic Murine Ovarian Cancer Model Reveals That Ascites Enriches for Ovarian Cancer Stem-Like Cells Expressing Membrane GRP78.
Targeting HSP90 in ovarian cancers with multiple receptor tyrosine kinase coactivation.
Tetrahydroquinoline units in flexible heteroarotinoids (Flex-Hets) convey anti-cancer properties in A2780 ovarian cancer cells.
The expression of FAS-associated factor 1 and heat shock protein 70 in ovarian cancer.
The involvement of small heat shock protein in chemoresistance in ovarian cancer - in vitro study.
Unfolded protein response, a link between endometrioid ovarian carcinoma and endometriosis: A pilot study.
[Effect of glucose regulated protein 78 on autophagy and apoptosis in ovarian epithelial carcinoma].
[Effects of ascites derived exosomes on the stemness and invasion ability of ovarian cancer stem-like cell].
[Inhibition of GRP78 expression reverses cisplatin resistance in human ovarian cancer].
Ovarian Torsion
Can adnexal torsion be predicted by measuring plasma heat shock protein 70 level? An experimental study.
Overweight
Circulating Hsp90 Isoform Levels in Overweight and Obese Children and the Relation to Nonalcoholic Fatty Liver Disease: Results from a Cross-Sectional Study.
Commensal Hafnia alvei strain reduces food intake and fat mass in obese mice-a new potential probiotic for appetite and body weight management.
Paget Disease, Extramammary
Heat shock protein 105 is overexpressed in squamous cell carcinoma and extramammary Paget disease but not in basal cell carcinoma.
Pancreatic Neoplasms
(-)-Epigallocatechin-3-gallate Inhibits Hsp90 Function by Impairing Hsp90 Association with Co-chaperones in Pancreatic Cancer Cell Line Mia Paca-2.
A novel Hsp90 inhibitor to disrupt Hsp90/Cdc37 complex against pancreatic cancer cells.
A Phase II Study of Ganetespib as Second-line or Third-line Therapy for Metastatic Pancreatic Cancer.
A phase II study of the HSP90 inhibitor AUY922 in chemotherapy refractory advanced pancreatic cancer.
A Randomized, Double-Blinded, Phase II Trial of Gemcitabine and Nab-Paclitaxel Plus Apatorsen or Placebo in Patients with Metastatic Pancreatic Cancer: The RAINIER Trial.
Androgen receptor signaling in hepatocellular carcinoma and pancreatic cancers.
Antiproliferative effect of HSP90 inhibitor Y306zh against pancreatic cancer is mediated by interruption of AKT and MAPK signaling pathways.
Antitumor activity and molecular effects of the novel heat shock protein 90 inhibitor, IPI-504, in pancreatic cancer.
Antitumor activity of mHSP65-TTL enhanced by administration of low dose cyclophosphamide in pancreatic cancer-bearing mice.
Changes in the Expression of Glucose-regulated Protein 78 in the Occurrence and Progression of Pancreatic Cancer in Mouse Models.
Chaperone-mediated autophagy degradation of IGF-1R? induced by NVP-AUY922 in pancreatic cancer.
CHIP is a novel tumor suppressor in pancreatic cancer through targeting EGFR.
Concomitant inhibition of HSP90, its mitochondrial localized homologue TRAP1 and HSP27 by green tea in pancreatic cancer HPAF-II cells.
Design and Function of Engineered Protein Nanocages as a Drug Delivery System for Targeting Pancreatic Cancer Cells via Neuropilin-1.
Dual mode of cancer cell destruction for pancreatic cancer therapy using Hsp90 inhibitor loaded polymeric nano magnetic formulation.
Elevated GRP78 expression is associated with poor prognosis in patients with pancreatic cancer.
Enzyme-treated Asparagus Extract Down-regulates Heat Shock Protein 27 of Pancreatic Cancer Cells.
Epigenetic effects of inhibition of heat shock protein 90 (HSP90) in human pancreatic and colon cancer.
ER stress sensor, glucose regulatory protein 78 (GRP78) regulates redox status in pancreatic cancer thereby maintaining "stemness".
Expression of heat shock protein 70 modulates the chemoresponsiveness of pancreatic cancer.
Expression of novel tumor markers of pancreatic adenocarcinomas in intrahepatic cholangiocarcinomas.
GRP78 promotes the invasion of pancreatic cancer cells by FAK and JNK.
GRP78-mediated antioxidant response and ABC transporter activity confers chemoresistance to pancreatic cancer cells.
Heat shock protein 27 as a prognostic and predictive biomarker in pancreatic ductal adenocarcinoma.
Heat Shock Protein 27 Expression in EUS-FNA Samples Can Predict Gemcitabine Sensitivity in Pancreatic Cancer.
Heat shock protein 47 confers chemoresistance on pancreatic cancer cells by interacting with calreticulin and IRE1?.
Heat Shock Protein 90 Inhibitor Effects on Pancreatic Cancer Cell Cultures.
Heat Shock Protein-90 Inhibition Alters Activation of Pancreatic Stellate Cells and Enhances the Efficacy of PD-1 Blockade in Pancreatic Cancer.
HIF-1alpha and STAT3 client proteins interacting with the cancer chaperone Hsp90: Therapeutic Considerations.
HSP90 inhibitors induce desensitization of EGF receptor via p38 MAPK-mediated phosphorylation at Ser1046/1047 in human pancreatic cancer cells.
HSP90 is a promising target in gemcitabine and 5-fluorouracil resistant pancreatic cancer.
Hyperthermia potentiates oncolytic herpes viral killing of pancreatic cancer through a heat shock protein pathway.
Inhibiting heat shock protein 90 and the ubiquitin-proteasome pathway impairs metabolic homeostasis and leads to cell death in human pancreatic cancer cells.
Inhibition of HSP90 overcomes resistance to chemotherapy and radiotherapy in pancreatic cancer.
Interaction between HSP60 and {beta}-catenin promotes metastasis.
Interferon-gamma down-regulates heat shock protein 27 of pancreatic cancer cells and helps in the cytotoxic effect of gemcitabine.
KNK437 downregulates heat shock protein 27 of pancreatic cancer cells and enhances the cytotoxic effect of gemcitabine.
Knockdown of glucose-regulated protein 78 enhances poly(ADP-ribose) polymerase cleavage in human pancreatic cancer cells exposed to endoplasmic reticulum stress.
Maslinic acid induces autophagy by down-regulating HSPA8 in pancreatic cancer cells.
MEK Inhibition Potentiates the Activity of Hsp90 Inhibitor 17-AAG against Pancreatic Cancer Cells.
Molecular chaperone HspB2 inhibited pancreatic cancer cell proliferation via activating p53 downstream gene RPRM, BAI1, and TSAP6.
Mortalin expression in pancreatic cancer and its clinical and prognostic significance.
Mutant p53, Stabilized by Its Interplay with HSP90, Activates a Positive Feed-Back Loop Between NRF2 and p62 that Induces Chemo-Resistance to Apigenin in Pancreatic Cancer Cells.
Non-invasive MRI tumor imaging and synergistic anticancer effect of HSP90 inhibitor and glycolysis inhibitor in RIP1-Tag2 transgenic pancreatic tumor model.
Novel agents in the treatment of pancreatic adenocarcinoma.
Novel triazole ribonucleoside down-regulates heat shock protein 27 and induces potent anticancer activity on drug-resistant pancreatic cancer.
Oncogenic HSP60 regulates mitochondrial oxidative phosphorylation to support Erk1/2 activation during pancreatic cancer cell growth.
Oncogenic MST1R activity in pancreatic and gastric cancer represents a valid target of HSP90 inhibitors.
Overexpression of heat shock protein (hsp) 70 associated with abnormal p53 expression in cancer of the pancreas.
Overexpression of heat shock protein 27 (HSP27) increases gemcitabine sensitivity in pancreatic cancer cells through S-phase arrest and apoptosis.
Oxidative inhibition of Hsp90 disrupts the super-chaperone complex and attenuates pancreatic adenocarcinoma in vitro and in vivo.
PET imaging of Hsp90 expression in pancreatic cancer using a new 64Cu-labeled dimeric Sansalvamide A decapeptide.
Phase II trial of gemcitabine and tanespimycin (17AAG) in metastatic pancreatic cancer: a Mayo Clinic Phase II Consortium study.
Phosphorylation status of heat shock protein 27 plays a key role in gemcitabine-induced apoptosis of pancreatic cancer cells.
Potentiation of chemotherapeutics by the Hsp90 antagonist geldanamycin requires a steady serum condition.
Proteomics finding heat shock protein 27 as a biomarker for resistance of pancreatic cancer cells to gemcitabine.
Radiofrequency ablation, heat shock protein 70 and potential anti-tumor immunity in hepatic and pancreatic cancers: a minireview.
RNAi knockdown of Hop (Hsp70/Hsp90 organising protein) decreases invasion via MMP-2 down regulation.
Role for NAD(P)H:quinone oxidoreductase 1 and manganese-dependent superoxide dismutase in 17-(Allylamino)-17-demethoxygeldanamycin-induced heat shock protein 90 inhibition in pancreatic cancer cells.
Role of GRP78 inhibiting artesunate-induced ferroptosis in KRAS mutant pancreatic cancer cells.
Role of heat shock protein 27 in gemcitabine-resistant human pancreatic cancer: Comparative proteomic analyses.
RP101 (brivudine) binds to heat shock protein HSP27 (HSPB1) and enhances survival in animals and pancreatic cancer patients.
Selective Cytotoxicity of Ponciri Fructus against Glucose-Deprived PANC-1 Human Pancreatic Cancer Cells via Blocking Activation of GRP78.
Serum HSP70: A Novel Biomarker for Early Detection of Pancreatic Cancer.
Small-Animal PET Imaging of Pancreatic Cancer Xenografts Using a 64Cu-Labeled Monoclonal Antibody, MAb159.
STAT3 and mutp53 Engage a Positive Feedback Loop Involving HSP90 and the Mevalonate Pathway.
Steady-State Levels of Phosphorylated Mitogen-Activated Protein Kinase Kinase 1/2 Determined by Mortalin/HSPA9 and Protein Phosphatase 1 Alpha in KRAS and BRAF Tumor Cells.
Structure-activity relationship (SAR) of withanolides to inhibit Hsp90 for its activity in pancreatic cancer cells.
Sulforaphane inhibits pancreatic cancer through disrupting Hsp90-p50(Cdc37) complex and direct interactions with amino acids residues of Hsp90.
Sulforaphane Potentiates the Efficacy of 17-Allylamino 17-Demethoxygeldanamycin Against Pancreatic Cancer Through Enhanced Abrogation of Hsp90 Chaperone Function.
Synergistic activity of Hsp90 inhibitors and anticancer agents in pancreatic cancer cell cultures.
Synergistic Antipancreatic Tumor Effect by Simultaneously Targeting Hypoxic Cancer Cells With HSP90 Inhibitor and Glycolysis Inhibitor.
Synthetic small interfering RNA targeting heat shock protein 105 induces apoptosis of various cancer cells both in vitro and in vivo.
Targeted delivery of chemotherapy using HSP90 inhibitor drug conjugates is highly active against pancreatic cancer models.
Targeting cell surface GRP78 enhances pancreatic cancer radiosensitivity through YAP/TAZ protein signaling.
Targeting Heat Shock Protein 90 in Pancreatic Cancer Impairs Insulin-like Growth Factor-I Receptor Signaling, Disrupts an Interleukin-6/Signal-Transducer and Activator of Transcription 3/Hypoxia-Inducible Factor-1{alpha} Autocrine Loop, and Reduces Orthotopic Tumor Growth.
Targeting HSP90 by the novel inhibitor NVP-AUY922 reduces growth and angiogenesis of pancreatic cancer.
Targeting the Janus-activated kinase-2-STAT3 signalling pathway in pancreatic cancer using the HSP90 inhibitor ganetespib.
The Clinical Significance of Phosphorylated Heat Shock Protein 27 (HSPB1) in Pancreatic Cancer.
The Effects of HSP27 on Gemcitabine-Resistant Pancreatic Cancer Cell Line Through Snail.
The hydroxyquinoline analog YUM70 inhibits GRP78 to induce ER stress-mediated apoptosis in pancreatic cancer.
The significance of phosphorylated heat shock protein 27 on the prognosis of pancreatic cancer.
Triptolide cooperates with Cisplatin to induce apoptosis in gemcitabine-resistant pancreatic cancer.
Triptolide induces pancreatic cancer cell death via inhibition of heat shock protein 70.
Triptolide induces the expression of miR-142-3p: a negative regulator of heat shock protein 70 and pancreatic cancer cell proliferation.
Ultrasensitive MRI detection of spontaneous pancreatic tumors with nanocage-based targeted contrast agent.
Uncovering Differently Expressed Markers and Heterogeneity on Human Pancreatic Cancer.
Withaferin A targets heat shock protein 90 in pancreatic cancer cells.
ZIP4 Promotes Muscle Wasting and Cachexia in Mice With Orthotopic Pancreatic Tumors by Stimulating RAB27B-Regulated Release of Extracellular Vesicles From Cancer Cells.
[Pancreatic acinar neoplasms : Comparative molecular characterization].
Pancreatitis
Acute pancreatitis results in induction of heat shock proteins 70 and 27 and heat shock factor-1.
Arginine induced acute pancreatitis alters the actin cytoskeleton and increases heat shock protein expression in rat pancreatic acinar cells.
Both thermal and non-thermal stress protect against caerulein induced pancreatitis and prevent trypsinogen activation in the pancreas.
Comparative effects of water immersion pretreatment on three different acute pancreatitis models in rats.
Differential induction of HSP60 and HSP72 by different stress situations in rats. Correlation with cerulein-induced pancreatitis.
Downregulation of GRP78 and XIAP is correlated with apoptosis during cerulein-induced acute pancreatitis in rats via regulation of caspase activation.
Electroacupuncture protects against CCK-induced acute pancreatitis in rats.
Extracellular heat-shock protein 70 aggravates cerulein-induced pancreatitis through toll-like receptor-4 in mice.
Functional role of J domain of cysteine string protein in Ca2+-dependent secretion from acinar cells.
Grp78 Heterozygosity Regulates Chaperone Balance in Exocrine Pancreas with Differential Response to Cerulein-Induced Acute Pancreatitis.
Heat shock protein 70 prevents secretagogue-induced cell injury in the pancreas by preventing intracellular trypsinogen activation.
Heat shock proteins in pancreatic diseases.
High Serum Levels of High-Mobility Group Box 1 (HMGB1) and Low Levels of Heat Shock Protein 70 (Hsp70) are Associated with Poor Prognosis in Patients with Acute Pancreatitis.
Hyperlipidemia induced by a cholesterol-rich diet aggravates necrotizing pancreatitis in rats.
Hyperthermia induces heat shock protein expression and protection against cerulein-induced pancreatitis in rats.
Hypertonic Saline Reduces Metalloproteinase Expression In Liver During Pancreatitis.
Induction of a 60-kDa heat shock protein in rat pancreas by water-immersion stress.
Induction of heat shock protein and prevention of caerulein-induced pancreatitis by water-immersion stress in rats.
Induction of heat shock proteins fails to produce protection against trypsin-induced acute pancreatitis in rats.
Induction of HSP72 by sodium arsenite fails to protect against cholecystokinin-octapeptide-induced acute pancreatitis in rats.
Ischemic preconditioning inhibits development of edematous cerulein-induced pancreatitis: Involvement of cyclooxygenases and heat shock protein 70.
Long-term ethanol consumption alters pancreatic gene expression in rats: a possible connection to pancreatic injury.
MAPKs and Hsc70 are critical to the protective effect of molecular hydrogen during the early phase of acute pancreatitis.
NF-kappaB activation is detrimental in arginine-induced acute pancreatitis.
Nontoxic heat shock protein coinducer BRX-220 protects against acute pancreatitis in rats.
Overexpression of heat shock protein Hsp27 protects against cerulein-induced pancreatitis.
Pioglitazone, a specific ligand of peroxisome proliferator-activated receptor-gamma, protects pancreas against acute cerulein-induced pancreatitis.
Polymorphism of the TNF-alpha, HSP70-2, and CD14 genes increases susceptibility to severe acute pancreatitis.
Pre-inhalation of hydrogen-rich gases protect against caerulein-induced mouse acute pancreatitis while enhance the pancreatic Hsp60 protein expression.
Prior peritoneal lavage with hot 0.9 % saline induces HSP70 expression and protects against cerulein-induced acute pancreatitis in rats.
Regulation of Hsp60 and the role of MK2 in a new model of severe experimental pancreatitis.
Regulation of HSP60 and the role of MK2 in a new model of severe experimental pancreatitis.
Serum heat shock protein 27 is increased in chronic pancreatitis and pancreatic carcinoma.
Simultaneous proteosome inhibition and heat shock protein induction by bortezomib is beneficial in experimental pancreatitis.
Sterile inflammatory response in acute pancreatitis.
Tethered Lipid Membranes as a Nanoscale Arrangement towards Non-Invasive Analysis of Acute Pancreatitis.
The effects of hypo- and hyperthermic pretreatment on sodium taurocholate-induced acute pancreatitis in rats.
Thermal stress-induced HSP70 mediates protection against intrapancreatic trypsinogen activation and acute pancreatitis in rats.
Water immersion pretreatment decreases pro-inflammatory cytokine production in cholecystokinin-octapeptide-induced acute pancreatitis in rats: possible role of HSP72.
Water immersion stress induces heat shock protein 60 expression and protects against pancreatitis in rats.
Water immersion stress induces heat shock protein expression and protects against pancreatitis.
Pancreatitis, Acute Necrotizing
VER-155008 induced Hsp70 proteins expression in fish cell cultures while impeding replication of two RNA viruses.
Pancreatitis, Chronic
Changes in the Expression of Glucose-regulated Protein 78 in the Occurrence and Progression of Pancreatic Cancer in Mouse Models.
Overexpression and localization of heat shock proteins mRNA in pancreatic carcinoma.
Polymorphisms of the MCP-1 and HSP70-2 genes in Korean patients with alcoholic chronic pancreatitis.
Proteins Differentially Expressed in the Pancreas of Hepatic Alcohol Dehydrogenase-Deficient Deer Mice Fed Ethanol For 3 Months.
Serum heat shock protein 27 is increased in chronic pancreatitis and pancreatic carcinoma.
Papilloma
Analysis of HSP90 Expression Is Valuable in the Differential Diagnosis of Ocular Surface Squamous Lesions.
Antisera against Neisseria gonorrhoeae cross-react with specific brain proteins of the common marmoset monkey and other nonhuman primate species.
Nuclear RNA accumulations contain released transcripts and exhibit specific distributions with respect to Sm antigen foci.
The effects of treated effluents on the intensity of papillomatosis and HSP70 expression in roach.
Papilloma, Choroid Plexus
Antisera against Neisseria gonorrhoeae cross-react with specific brain proteins of the common marmoset monkey and other nonhuman primate species.
Papillomavirus Infections
Effect of human papillomavirus infection on estrogen receptor and heat shock protein hsp27 phenotype in human cervix and vagina.
Immunohistochemical evaluation of heat shock proteins in normal and preinvasive lesions of the cervix.
Technology evaluation: HspE7 (Stressgen).
Paracoccidioidomycosis
A new Paracoccidioides brasiliensis 70-kDa heat shock protein reacts with sera from paracoccidioidomycosis patients.
Detrimental Effect of Fungal 60-kDa Heat Shock Protein on Experimental Paracoccidioides brasiliensis Infection.
Heterologous expression, purification, and immunological reactivity of a recombinant HSP60 from Paracoccidioides brasiliensis.
Molecular cloning, characterization and expression of the heat shock protein 60 gene from the human pathogenic fungus Paracoccidioides brasiliensis.
Paraganglioma
Diagnosis and surgical treatment of retroperitoneal paraganglioma: A single-institution experience of 34 cases.
Paralysis
Expression of heat shock protein epitopes in tubular aggregates.
Heat shock treatment reduces beta amyloid toxicity in vivo by diminishing oligomers.
Increased levels of Stress-inducible phosphoprotein-1 accelerates amyloid-? deposition in a mouse model of Alzheimer's disease.
Preoperative stress conditioning prevents paralysis after experimental aortic surgery: increased heat shock protein content is associated with ischemic tolerance of the spinal cord.
The Small Heat Shock Protein HSP25/27 (HspB1) Is Abundant in Cultured Astrocytes and Associated with Astrocytic Pathology in Progressive Supranuclear Palsy and Corticobasal Degeneration.
Paraneoplastic Syndromes, Ocular
Cancer-associated retinopathy induced by both anti-recoverin and anti-hsc70 antibodies in vivo.
Invasive thymoma with paraneoplastic retinopathy.
Mechanisms of photoreceptor cell death in cancer-associated retinopathy.
Paraparesis
Decreased expression of the mitochondrial matrix proteases Lon and ClpP in cells from a patient with hereditary spastic paraplegia (SPG13).
Paraparesis, Spastic
HSP60 is a rare cause of hereditary spastic paraparesis, but may act as a genetic modifier.
Paraplegia
Late onset motoneuron disorder caused by mitochondrial Hsp60 chaperone deficiency in mice.
Paraproteinemias
Expression and release of glucose-regulated protein-78 (GRP78) in multiple myeloma.
Role of Specific B-Cell Receptor Antigens in Lymphomagenesis.
STAT3 and MAPK signaling maintain overexpression of heat shock proteins 90alpha and beta in multiple myeloma cells, which critically contribute to tumor-cell survival.
Sumoylated HSP90 is a dominantly inherited plasma cell dyscrasias risk factor.
Parasitemia
Susceptibility of heat shock protein 70.1-deficient C57BL/6 J, wild-type C57BL/6 J and A/J mice to Trypanosoma congolense infection.
Parasitic Diseases
17-AAG-Induced Activation of the Autophagic Pathway in Leishmania Is Associated with Parasite Death.
A Case of Adenomyosis with a High Titer of IgG Autoantibody to Calreticulin.
A chemical inhibitor of heat shock protein 78 (HSP78) from Leishmania donovani represents a potential antileishmanial drug candidate.
Hsp90 Inhibitors in Parasitic Nematodes: Prospects and Challenges.
Identification and characterization of the antiplasmodial activity of Hsp90 inhibitors.
Repurposing drugs to target the malaria parasite unfolding protein response.
Targeting Hsp90 in Non-Cancerous Maladies.
Paratuberculosis
Anti Mycobacterium avium subsp. paratuberculosis heat shock protein 70 antibodies in the sera of Sardinian patients with multiple sclerosis.
Complete nucleotide sequence of a gene encoding the 70 kd heat shock protein of Mycobacterium paratuberculosis.
Cytokine gene expression profiles of bovine dendritic cells after interaction with Mycobacterium avium ssp. paratuberculosis (M.a.p.), Escherichia coli (E. coli) or recombinant M.a.p. heat shock protein 70.
Development and use of a partial Mycobacterium avium subspecies paratuberculosis protein array.
Development of DNA-Designed Avian IgY Antibodies for Detection of Mycobacterium avium subsp. paratuberculosis Heat Shock Protein 70 (Hsp70) and Anti-Hsp70 Antibodies in the Serum of Normal Cattle.
Heat shock protein 70 subunit vaccination against bovine paratuberculosis does not interfere with current immunodiagnostic assays for bovine tuberculosis.
Identification and characterization of Mycobacterium paratuberculosis recombinant proteins expressed in E. coli.
Identification of Mycobacterium avium complex in sarcoidosis.
Induction of humoral immunity in response to immunization with recombinant Mycobacterium bovis BCG expressing the S1 subunit of Bordetella pertussis toxin.
M. paratuberculosis Heat Shock Protein 65 and Human Diseases: Bridging Infection and Autoimmunity.
Mycobacteria in the intestine of Japanese patients with inflammatory bowel disease.
Mycobacterium avium ssp. paratuberculosis recombinant heat shock protein 70 interaction with different bovine antigen-presenting cells.
Mycobacterium paratuberculosis heat shock protein 70 as a tool in control of paratuberculosis.
Nucleotide sequence analysis and seroreactivities of the 65K heat shock protein from Mycobacterium paratuberculosis.
Post-exposure subunit vaccination against chronic enteric mycobacterial infection in a natural host.
Rapid differentiation of Mycobacterium avium and M. paratuberculosis by PCR and restriction enzyme analysis.
Parkinson Disease
A chemical genomics-aggrephagy integrated method studying functional analysis of autophagy inducers.
A novel bio-orthogonal cross-linker for improved protein/protein interaction analysis.
Age-dependent accumulation of oligomeric SNCA/?-synuclein from impaired degradation in mutant LRRK2 knockin mouse model of Parkinson disease: role for therapeutic activation of chaperone-mediated autophagy (CMA).
Alternative mitochondrial quality control mediated by extracellular release.
Analysis of heat-shock protein 70 gene polymorphisms and the risk of Parkinson's disease.
Applying Hsp104 to protein-misfolding disorders.
Are heat shock proteins therapeutic target for Parkinson's disease?
Arylsulfatase A, a genetic modifier of Parkinson's disease, is an ?-synuclein chaperone.
Autophagy inhibition rescues structural and functional defects caused by the loss of mitochondrial chaperone Hsc70-5 in Drosophila.
BAG5 Promotes Alpha-Synuclein Oligomer Formation and Functionally Interacts With the Autophagy Adaptor Protein p62.
Chaperone-mediated autophagy controls the turnover of E3 ubiquitin ligase MARCHF5 and regulates mitochondrial dynamics.
Congrong Shujing Granule-Induced GRP78 Expression Reduced Endoplasmic Reticulum Stress and Neuronal Apoptosis in the Midbrain in a Parkinson's Disease Rat Model.
CSF Nrf2 and HSPA8 in Parkinson's disease patients with and without LRRK2 gene mutations.
Curcumin Protects an SH-SY5Y Cell Model of Parkinson's Disease Against Toxic Injury by Regulating HSP90.
Dissecting the role of the mitochondrial chaperone mortalin in Parkinson's disease: functional impact of disease-related variants on mitochondrial homeostasis.
DJ-1 protects against neurodegeneration caused by focal cerebral ischemia and reperfusion in rats.
DJ-1/PARK7: A New Therapeutic Target for Neurodegenerative Disorders.
Effect of endogenous Hsp104 chaperone in yeast models of sporadic and familial Parkinson's disease.
Engineered protein disaggregases mitigate toxicity of aberrant prion-like fusion proteins underlying sarcoma.
Enhancement of the Anti-Aggregation Activity of a Molecular Chaperone Using a Rationally Designed Post-Translational Modification.
Evaluating the role of ARSA in Chinese patients with Parkinson's disease.
Expression of the human groEL stress-protein homologue in the brain and spinal cord.
Functional Significance of Point Mutations in Stress Chaperone Mortalin and Their Relevance to Parkinson Disease.
Geldanamycin induces heat shock protein 70 and protects against MPTP-induced dopaminergic neurotoxicity in mice.
GRP78 Level Is Altered in the Brain, but Not in Plasma or Cerebrospinal Fluid in Parkinson's Disease Patients.
Heat shock protein 70 reduces ?-synuclein-induced predegenerative neuronal dystrophy in the ?-synuclein viral gene transfer rat model of Parkinson's disease.
Heat shock protein 90 is a potential therapeutic target for ameliorating skeletal muscle abnormalities in Parkinson's disease.
Heat shock protein 90 modulates LRRK2 stability: potential implications for Parkinson's disease treatment.
Heat shock protein-70 (Hsp-70) suppresses paraquat-induced neurodegeneration by inhibiting JNK and caspase-3 activation in Drosophila model of Parkinson's disease.
Heat shock proteins in neurodegenerative disorders and aging.
Hsc70 interaction with soluble and fibrillar {alpha}-Synuclein.
Hsp104 antagonizes alpha-synuclein aggregation and reduces dopaminergic degeneration in a rat model of Parkinson disease.
Hsp104 targets multiple intermediates on the amyloid pathway and suppresses the seeding capacity of Abeta fibrils and protofibrils.
Hsp90 and Its Co-Chaperones in Neurodegenerative Diseases.
HSP90 and Its Novel Co-Chaperones, SGT1 and CHP-1, in Brain of Patients with Parkinson's Disease and Dementia with Lewy Bodies.
Hsp90 Co-chaperone p23 contributes to dopaminergic mitochondrial stress via stabilization of PHD2: Implications for Parkinson's disease.
Human-based studies on alpha-synuclein deposition and relationship to Parkinson's disease symptoms.
Identification of protein interfaces between alpha-synuclein, the principal component of Lewy bodies in Parkinson's disease, and the molecular chaperones human Hsc70 and the yeast Ssa1p.
Increase in anti-apoptotic molecules, nucleolin, and heat shock protein 70, against upregulated LRRK2 kinase activity.
Increased heat shock transcription factor 1 in the cerebellum reverses the deficiency of Purkinje cells in Alzheimer's disease.
Increased Striatal mRNA and Protein Levels of the Immunophilin FKBP-12 in Experimental Parkinson's Disease and Identification of FKBP-12-Binding Proteins.
Interaction of the molecular chaperone alphaB-crystallin with alpha-synuclein: effects on amyloid fibril formation and chaperone activity.
Interactions between Hsp70 and the hydrophobic core of alpha-synuclein inhibit fibril assembly.
Kinetic and structural characterization of human mortalin.
Knockdown of Hsc70-5/mortalin induces loss of synaptic mitochondria in a Drosophila Parkinson's disease model.
Linking HSP90 target occupancy to HSP70 induction and efficacy in mouse brain.
Loss of HSPA9 induces peroxisomal degradation by increasing pexophagy.
LRRK2 mutations impair depolarization-induced mitophagy through inhibition of mitochondrial accumulation of RAB10.
Mechanisms of Suppression of {alpha}-Synuclein Neurotoxicity by Geldanamycin in Drosophila.
Mechanistic Insights into Hsp104 Potentiation.
miR-16-1 promotes the aberrant ?-synuclein accumulation in parkinson disease via targeting heat shock protein 70.
Mitochondrial proteolytic stress induced by loss of mortalin function is rescued by Parkin and PINK1.
Molecular Chaperones as Rational Drug Targets for Parkinson's Disease Therapeutics.
Mortalin and DJ-1 coordinately regulate hematopoietic stem cell function through the control of oxidative stress.
Mortalin inhibition in experimental Parkinson's disease.
Mortalin is Expressed by Astrocytes and Decreased in the Midbrain of Parkinson's Disease Patients.
Mortalin mutations are not a frequent cause of early-onset Parkinson disease.
MPTP-induced model of Parkinson's disease in heat shock protein 70.1 knockout mice.
Mutational screening of the mortalin gene (HSPA9) in Parkinson's disease.
Neurodevelopmental defects and neurodegenerative phenotypes in human brain organoids carrying Parkinson's disease-linked DNAJC6 mutations.
Operational plasticity enables hsp104 to disaggregate diverse amyloid and nonamyloid clients.
Protective effect of planarian DJ-1 against 6-hydroxydopamine-induced neurotoxicity.
Proteomic profiling of phosphoproteins and glycoproteins responsive to wild-type alpha-synuclein accumulation and aggregation.
Psychotropics regulate Skp1a, Aldh1a1, and Hspa8 transcription--potential to delay Parkinson's disease.
Purification of hsp104, a protein disaggregase.
Reduced expression of the chaperone-mediated autophagy carrier hsc70 protein in lymphomonocytes of patients with Parkinson's disease.
Serum Mortalin Correlated with ?-Synuclein as Serum Markers in Parkinson's Disease: A Pilot Study.
Silencing of Hsp70 Intensifies 6-OHDA-Induced Apoptosis and Hsp90 Upregulation in PC12 Cells.
Stressing Out Hsp90 in Neurotoxic Proteinopathies.
Structure and function of the molecular chaperone Hsp104 from yeast.
Targeting Hsp90/Hsp70-based protein quality control for treatment of adult onset neurodegenerative diseases.
The Expression and Release of Hsp60 in 6-OHDA Induced In Vivo and In Vitro Models of Parkinson's Disease.
The interaction of Hsc70 protein with fibrillar ?-Synuclein and its therapeutic potential in Parkinson's disease.
The lysosomal membrane protein LAMP2A promotes autophagic flux and prevents SNCA-induced Parkinson disease-like symptoms in the Drosophila brain.
The mammalian disaggregase machinery: Hsp110 synergizes with Hsp70 and Hsp40 to catalyze protein disaggregation and reactivation in a cell-free system.
The Molecular Chaperone GRP78/BiP as a Therapeutic Target for Neurodegenerative Disorders: A Mini Review.
The role of thioredoxin-1 in suppression of endoplasmic reticulum stress in Parkinson disease.
Transcription- and phosphorylation-dependent control of a functional interplay between XBP1s and PINK1 governs mitophagy and potentially impacts Parkinson disease pathophysiology.
Trehalose induces autophagy via lysosomal-mediated TFEB activation in models of motoneuron degeneration.
Uncaria rhynchophylla Ameliorates Parkinson's Disease by Inhibiting HSP90 Expression: Insights from Quantitative Proteomics.
Parkinsonian Disorders
Chronic treatment with novel small molecule Hsp90 inhibitors rescues striatal dopamine levels but not ?-synuclein-induced neuronal cell loss.
Crystal structures of human DJ-1 and Escherichia coli Hsp31, which share an evolutionarily conserved domain.
Effects of Exercise and Ferulic Acid on Alpha Synuclein and Neuroprotective Heat Shock Protein 70 in An Experimental Model of Parkinsonism Disease.
Pars Planitis
Peptidic sequence "HSEAETGPP" is recognized by the sera of pars planitis patients.
Pelvic Inflammatory Disease
Antibody response to the chlamydial heat-shock protein 60 in an experimental model of chronic pelvic inflammatory disease in monkeys (Macaca nemestrina).
Antibody to chlamydial hsp60 predicts an increased risk for chlamydial pelvic inflammatory disease.
Chlamydia antibodies, chlamydia heat shock protein, and adverse sequelae after pelvic inflammatory disease: the PID Evaluation and Clinical Health (PEACH) Study.
Chlamydia trachomatis detection in a population of asymptomatic and symptomatic women: correlation with the presence of serological markers for this infection.
Differential human serologic response to two 60,000 molecular weight Chlamydia trachomatis antigens.
Humoral immune response to conserved epitopes of Chlamydia trachomatis and human 60-kDa heat-shock protein in women with pelvic inflammatory disease.
Prevalence and correlates of antibody to chlamydial heat shock protein in women attending sexually transmitted disease clinics and women with confirmed pelvic inflammatory disease.
Reduced levels of gamma-interferon secretion in response to chlamydial 60 kDa heat shock protein amongst women with pelvic inflammatory disease and a history of repeated Chlamydia trachomatis infections.
Pemphigoid, Benign Mucous Membrane
Collagens, collagen-binding heat shock protein 47 and transforming growth factor-beta 1 are induced in cicatricial pemphigoid: possible role(s) in dermal fibrosis.
Endoplasmic reticulum stress promotes inflammation-mediated proteolytic activity at the ocular surface.
Heat shock protein expression in human conjunctiva.
Role of collagen-binding heat shock protein 47 and transforming growth factor-beta1 in conjunctival scarring in ocular cicatricial pemphigoid.
Pemphigoid, Bullous
Aberrant expression and secretion of heat shock protein 90 in patients with bullous pemphigoid.
Autoantibodies to human stress proteins. A survey of various rheumatic and other inflammatory diseases.
Evidence for a role of autoantibodies to heat shock protein 60, 70, and 90 in patients with dermatitis herpetiformis.
Heat shock protein 90 inhibition: A potential double- or triple-edged sword in the treatment of mucous membrane pemphigoid.
Heat shock protein 90: a pathophysiological factor and novel treatment target in autoimmune bullous skin diseases.
Hsp90 blockade modulates bullous pemphigoid IgG-induced IL-8 production by keratinocytes.
Sequence homologies between hsp60 and autoantigens.
Pemphigus
Aberrant expression and secretion of heat shock protein 90 in patients with bullous pemphigoid.
Autoantibodies in the autoimmune disease pemphigus foliaceus induce blistering via p38 mitogen-activated protein kinase-dependent signaling in the skin.
Evidence for a role of autoantibodies to heat shock protein 60, 70, and 90 in patients with dermatitis herpetiformis.
Is there any relationship between polymorphism of Heat Shock Protein 70 genes and Pemphigus foliaceus?
Pemphigus serum and captopril induce heat shock protein 70 and inducible nitric oxide synthase overexpression, triggering apoptosis in human keratinocytes.
Peptic Ulcer
Role of Heat-Shock Protein (HSP) 70-2 Genotype in Peptic Ulcer in Japanese Population.
Peri-Implantitis
Altered immunolocalization of heat-shock proteins in human peri-implant gingiva.
Periapical Periodontitis
The virulence factor GroEL promotes gelatinase secretion from cells in the osteoblast lineage: Implication for direct crosstalk between bacteria and adult cells.
Pericardial Effusion
Humoral response to mycobacterial heat shock proteins in patients with constrictive pericarditis caused by tuberculosis and its implications for pathogenesis.
Perinatal Death
Aberrant gene expression in organs of bovine clones that die within two days after birth.
Neonatal Death and Heart Failure in Mouse with Transgenic HSP60 Expression.
Periodontal Diseases
Construction and characterization of a Porphyromonas gingivalis htpG disruption mutant.
Epitope mapping of heat shock protein 60 (GroEL) from Porphyromonas gingivalis.
Evaluation of Salivary Level of Heat Shock Protein 70 in Patients with Chronic Periodontitis.
Heat-shock protein 60 kDa and atherogenic dyslipidemia in patients with untreated mild periodontitis: a pilot study.
Helicobacter pylori and Campylobacter rectus share a common antigen.
Identification of immunological parameters associated with the alveolar bone level in periodontal patients.
Porphyromonas gingivalis GroEL induces osteoclastogenesis of periodontal ligament cells and enhances alveolar bone resorption in rats.
Porphyromonas gingivalis heat shock protein vaccine reduces the alveolar bone loss induced by multiple periodontopathogenic bacteria.
Predominant immunoreactivity of Porphyromonas gingivalis heat shock protein in autoimmune diseases.
Salivary immunoglobulin A directed to oral microbial GroEL in patients with periodontitis and their potential protective role.
Self-heat shock protein 60 induces tumour necrosis factor-alpha in monocyte-derived macrophage: possible role in chronic inflammatory periodontal disease.
The GroEL protein of Porphyromonas gingivalis accelerates tumor growth by enhancing endothelial progenitor cell function and neovascularization.
Periodontal Pocket
Putative heat shock protein 70 gene from Actinobacillus actinomycetemcomitans: molecular cloning and sequence analysis of its gene.
Periodontitis
Accumulation of human heat shock protein 60-reactive T cells in the gingival tissues of periodontitis patients.
Balance of inflammatory response in stable gingivitis and progressive periodontitis lesions.
Characterization of serum antibody to Actinobacillus actinomycetemcomitans GroEL-like protein in periodontitis patients and healthy subjects.
Differential regulation of circulating levels of molecular chaperones in patients undergoing treatment for periodontal disease.
Effect of endoplasmic reticulum stress-induced apoptosis in the role of periodontitis on vascular calcification in a rat model.
Effects of Initial Periodontal Therapy on Heat Shock Protein 70 Levels in Gingival Crevicular Fluid from Periodontitis Patients.
Elevated humoral immune response to heat shock protein 60 (hsp60) family in periodontitis patients.
Epitope mapping of heat shock protein 60 (GroEL) from Porphyromonas gingivalis.
Fusobacterium nucleatum GroEL induces risk factors of atherosclerosis in human microvascular endothelial cells and ApoE(-/-) mice.
Heat-shock protein 60 kDa and atherogenic dyslipidemia in patients with untreated mild periodontitis: a pilot study.
Humoral immune response to heat shock protein 60 of Aggregatibacter actinomycetemcomitans and cross-reactivity with malondialdehyde acetaldehyde-modified LDL.
Identification of immunoreactive epitopes of the Porphyromonas gingivalis heat shock protein in periodontitis and atherosclerosis.
Identification of mono- or poly-specific monoclonal antibody to Porphyromonas gingivalis heat-shock protein 60.
Identification of T-cell epitopes of Porphyromonas gingivalis heat-shock-protein 60 in periodontitis.
Immune responses to heat shock protein in Porphyromonas gingivalis-infected periodontitis and atherosclerosis patients.
Molecular and immunological characterization of a 64-kDa protein of Actinobacillus actinomycetemcomitans.
Natural Monoclonal Antibody to Oxidized Low-Density Lipoprotein and Aggregatibacter actinomycetemcomitans.
Pep19 drives epitope spreading in periodontitis and periodontitis-associated autoimmune diseases.
Periodontopathogen- and host-derived immune response in acute coronary syndrome.
Porphyromonas gingivalis GroEL induces osteoclastogenesis of periodontal ligament cells and enhances alveolar bone resorption in rats.
Predominant immunoreactivity of Porphyromonas gingivalis heat shock protein in autoimmune diseases.
Relationships between the onset of pustulosis palmaris et plantaris, periodontitis and bacterial heat shock proteins.
Robust immunoreactivity of teenager sera against peptide 19 from Porphyromonas gingivalis HSP60.
Salivary immunoglobulin A directed to oral microbial GroEL in patients with periodontitis and their potential protective role.
Self-heat shock protein 60 induces tumour necrosis factor-alpha in monocyte-derived macrophage: possible role in chronic inflammatory periodontal disease.
Serum antibodies to Porphyromonas gingivalis chaperone HtpG predict health in periodontitis susceptible patients.
Serum antibody response to group II chaperonin from Methanobrevibacter oralis and human chaperonin CCT.
T-cell clonality to Porphyromonas gingivalis and human heat shock protein 60s in patients with atherosclerosis and periodontitis.
The immune responses to human and microbial heat shock proteins in periodontal disease with and without coronary heart disease.
Up-regulation of the endoplasmic reticulum stress-response in periodontal disease.
[Expression and significance of chemokines CCL21, E-selectins and Hsp90 in periodontal tissues of rats with experimental periodontitis].
[Serum, oral and gingival fluid levels of heat shock protein-70, cytokines and their autoantibodies by periodontal disease].
Peripheral Arterial Disease
Plasma heat shock protein 27 is associated with coronary artery disease, abdominal aortic aneurysm and peripheral artery disease.
Serum level of soluble Hsp70 is associated with vascular calcification.
[Role of chronic infection and heat shock proteins in peripheral arterial disease]
Peripheral Nerve Injuries
Heat shock protein 27: developmental regulation and expression after peripheral nerve injury.
Heat shock protein is a key therapeutic target for nerve repair in autoimmune peripheral neuropathy and severe peripheral nerve injury.
Mutant HSPB1 overexpression in neurons is sufficient to cause age-related motor neuronopathy in mice.
Peripheral Nervous System Diseases
Characterization of human small heat shock protein HSPB1 ?-crystallin domain localized mutants associated with hereditary motor neuron diseases.
Characterization of New Transgenic Mouse Models for Two Charcot-Marie-Tooth-Causing HspB1 Mutations using the Rosa26 Locus.
Heat shock protein 90 inhibitors block the antinociceptive effects of opioids in mouse chemotherapy-induced neuropathy and cancer bone pain models.
Heat shock protein is a key therapeutic target for nerve repair in autoimmune peripheral neuropathy and severe peripheral nerve injury.
Identification of the Drosophila ortholog of HSPB8: implication of HSPB8 loss of function in protein folding diseases.
KU-32, a novel drug for diabetic neuropathy, is safe for human islets and improves in vitro insulin secretion and viability.
Physico-chemical properties of R140G and K141Q mutants of human small heat shock protein HspB1 associated with hereditary peripheral neuropathies.
Significance of functional GRP78 polymorphisms in predicting the onset of type 2 diabetic peripheral neuropathy in Chinese population.
Synthesis and evaluation of novologues as C-terminal Hsp90 inhibitors with cytoprotective activity against sensory neuron glucotoxicity.
Targeting the Diabetic Chaperome to Improve Peripheral Neuropathy.
Peritoneal Fibrosis
Antisense oligonucleotides against collagen-binding stress protein HSP47 suppress peritoneal fibrosis in rats.
Enhanced expression of heat shock protein 47 in rat model of peritoneal fibrosis.
The kampo medicine daikenchuto inhibits peritoneal fibrosis in mice.
Peritoneal Neoplasms
Impact of hyperthermic intraperitoneal chemotherapy on Hsp27 protein expression in serum of patients with peritoneal carcinomatosis.
Peritonitis
Geranylgeranylacetone attenuates septic diaphragm dysfunction by induction of heat shock protein 70.
Heat shock protein 72 enhances autophagy as a protective mechanism in lipopolysaccharide-induced peritonitis in rats.
Inhibition of the NLRP3 inflammasome by HSP90 inhibitors.
Nitric oxide synthase-2 regulates mitochondrial Hsp60 chaperone function during bacterial peritonitis in mice.
Persistent Infection
Association of serum-soluble heat shock protein 60 with carotid atherosclerosis: clinical significance determined in a follow-up study.
Association of uterine and salpingeal fibrosis with chlamydial hsp60 and hsp10 antigen-specific antibodies in Chlamydia-infected koalas.
Avidity of anti-P aeruginosa antibodies during chronic infection in patients with cystic fibrosis.
Chronic Infections and Atherosclerosis.
Cross-reactivity of GroEL antibodies with human heat shock protein 60 and quantification of pathogens in atherosclerosis.
Heat shock protein 10 of Chlamydophila pneumoniae induces proinflammatory cytokines through Toll-like receptor (TLR) 2 and TLR4 in human monocytes THP-1.
Inhibition of Heat Shock Protein 90 Prevents HIV Rebound.
Is chlamydial heat shock protein 60 a risk factor for oncogenesis?
Oxidized low-density lipoprotein autoantibodies, chronic infections, and carotid atherosclerosis in a population-based study.
Persistence of Chlamydia pneumoniae in degenerative aortic valve stenosis indicated by heat shock protein 60 homologues.
Persistent Chlamydia trachomatis infections resist apoptotic stimuli.
Post-exposure subunit vaccination against chronic enteric mycobacterial infection in a natural host.
Regulation of Molecular Chaperone GRP78 by Hepatitis B Virus: Control of Viral Replication and Cell Survival.
The heat shock response of mycobacterium tuberculosis: linking gene expression, immunology and pathogenesis.
Peste-des-Petits-Ruminants
Autophagy in farm animals: current knowledge and future challenges.
Selection and validation of suitable reference genes for qPCR gene expression analysis in goats and sheep under Peste des petits ruminants virus (PPRV), lineage IV infection.
Pheochromocytoma
Effect of HSP90 inhibitor in pheochromocytoma PC12 cells: an experimental investigation.
Effects of geldanamycin on neurite outgrowth-related proteins and kinases in nerve growth factor-differentiated pheochromocytoma 12 cells.
Enantioselective effect of bifenthrin on antioxidant enzyme gene expression and stress protein response in PC12 cells.
Erratum to: Effect of HSP90 inhibitor in pheochromocytoma PC12 cells: an experimental investigation.
Expression and diagnostic relevance of heat shock protein 90 and signal transducer and activator of transcription 3 in malignant pheochromocytoma.
Glucose-regulated protein 75 overexpression attenuates ionizing radiation-mediated injury in PC12 cells by inducing the expression of topoisomerase II?
HSP90 is a key for telomerase activation and malignant transition in pheochromocytoma.
Neural differentiation and the attenuated heat shock response.
Neuroprotective effect of dipeptide AVP(4-5)-NH2 is associated with nerve growth factor and heat shock protein HSP70.
NVP-AUY922, a novel HSP90 inhibitor, inhibits the progression of malignant pheochromocytoma in vitro and in vivo.
Partial rescue of geldanamycin-induced TrkA depletion by a proteasome inhibitor in PC12 cells.
Supraphysiological doses of performance enhancing anabolic-androgenic steroids exert direct toxic effects on neuron-like cells.
Targeting heat shock protein 90 for the treatment of malignant pheochromocytoma.
The HSP90 inhibitor 17-AAG exhibits potent antitumor activity for pheochromocytoma in a xenograft model.
Withdrawal. HSP90 is a key for telomerase activation and malignant transition in pheochromocytoma.
Photosensitivity Disorders
Induction of Hsp60 by Photofrin-mediated photodynamic therapy.
Phytoplasma Disease
'Candidatus Phytoplasma asteris' Strains Associated with Oil Palm Lethal Wilt in Colombia.
Waltheria indica is a New Host of Phytoplasma Belongs to 16SrI-B Subgroup Associated with Virescence Symptoms in China.
Pituitary ACTH Hypersecretion
A C-terminal HSP90 inhibitor restores glucocorticoid sensitivity and relieves a mouse allograft model of Cushing disease.
Regulation of the EGFR Pathway by HSP90 Is Involved in the Pathogenesis of Cushing's Disease.
Pituitary Neoplasms
Elevated levels of mortalin expression in human brain tumors.
Plague
Development of a high-throughput screening cancer cell-based luciferase refolding assay for identifying Hsp90 inhibitors.
Taxa-specific heat shock proteins are over-expressed with crowding in the Australian plague locust.
Plant Diseases
GroEL protein from the potential biocontrol agent Rhodopseudomonas palustris enhances resistance to rice blast disease.
High throughput virus-induced gene silencing implicates heat shock protein 90 in plant disease resistance.
The Noncompetitive Effect of Gambogic Acid Displaces Fluorescence-Labeled ATP but Requires ATP for Binding to Hsp90/HtpG.
Plasmacytoma
The major inducible heat shock protein hsp68 is not required for acquisition of thermal resistance in mouse plasmacytoma cell lines.
Pleural Diseases
Mesothelial cells activate the plasma kallikrein-kinin system during pleural inflammation.
Pneumococcal Infections
DnaJ (hsp40) of Streptococcus pneumoniae is involved in bacterial virulence and elicits a strong natural immune reaction via PI3K/JNK.
Immunization with a ZmpB-based protein vaccine could protect against pneumococcal diseases in mice.
Pneumoconiosis
Polymorphisms in Heat-shock Protein 70 Genes Are Associated with Coal Workers' Pneumoconiosis in Southwestern China.
[Effect of HSP70 gene polymorphism on genetic susceptibility of pneumoconiosis of coal worker]
Pneumonia
Anandamide enhances expression of heat shock protein 72 to protect against ischemia-reperfusion injury in rat heart.
Antibody response to B cell epitopes of Chlamydia trachomatis 60-kDa heat-shock protein and corresponding mycobacterial and human peptides in infants with chlamydial pneumonitis.
Differential heat shock gene hsp70-1 response to toxicants revealed by in vivo study of lungs in transgenic mice.
Effects of repeated Chlamydia pneumoniae inoculations on aortic lipid accumulation and inflammatory response in C57BL/6J mice.
Endoplasmic reticulum chaperone gp96 in macrophages is essential for protective immunity during Gram-negative pneumonia.
Grp78 Loss in Epithelial Progenitors Reveals an Age-linked Role for Endoplasmic Reticulum Stress in Pulmonary Fibrosis.
Heat shock protein 70-2+1267 AA homozygotes have an increased risk of septic shock in adults with community-acquired pneumonia.
Heat shock response and acute lung injury.
High GRP78 levels in Covid-19 infection: A case-control study.
HSP90 inhibition suppresses lipopolysaccharide-induced lung inflammation in vivo.
Hypertonic saline solution increases the expression of heat shock protein 70 and improves lung inflammation early after reperfusion in a rodent model of controlled hemorrhage.
Immune responses of a chimaeric protein vaccine containing Mycoplasma hyopneumoniae antigens and LTB against experimental M. hyopneumoniae infection in pigs.
Induction of infertility by the Chlamydia trachomatis mouse pneumonitis biovar in strains of mice that differ in their response to the 60 kDa heat shock protein.
Involvement of collagen-binding heat shock protein 47 and procollagen type I synthesis in idiopathic pulmonary fibrosis: contribution of type II pneumocytes to fibrosis.
Lack of protection in mice and necrotizing bronchointerstitial pneumonia with bronchiolitis in guinea pigs immunized with vaccines directed against the hsp60 molecule of Mycobacterium tuberculosis.
Long-Term Efficacy and Safety of Immunomodulatory Therapy for Atherosclerosis.
NLRP3 inflammasome activation in aged macrophages is diminished during Streptococcus pneumoniae infection.
Oral dosing with multi-antigenic construct induces atheroprotective immune tolerance to individual peptides in mice.
Preliminary Virtual Screening Studies to Identify GRP78 Inhibitors Which May Interfere with SARS-CoV-2 Infection.
Structural insights into the formation of oligomeric state by a type I Hsp40 chaperone.
The sequence of the groES and groEL genes from the mouse pneumonitis agent of Chlamydia trachomatis.
Ventilator-induced heat shock protein 70 and cytokine mRNA expression in a model of lipopolysaccharide-induced lung inflammation.
Pneumonia, Mycoplasma
Antibody response to GroEL varies in patients with acute Mycoplasma pneumoniae infection.
Pneumonia, Pneumocystis
Development of an RT-PCR on the heat shock protein 70 gene for viability detection of Pneumocystis carinii f. sp. hominis in patients with pneumocystosis and in air sample.
Pneumoperitoneum
Comparison of the stress response in patients undergoing gynecological laparoscopic surgery using carbon dioxide pneumoperitoneum or abdominal wall-lifting methods.
Polycystic Kidney Diseases
Bi-allelic pathogenic variations in DNAJB11 cause Ivemark II syndrome, a renal-hepatic-pancreatic dysplasia.
Inhibiting the HSP90 chaperone slows cyst growth in a mouse model of autosomal dominant polycystic kidney disease.
Therapeutic targeting of BET bromodomain protein, Brd4, delays cyst growth in ADPKD.
Polycystic Kidney, Autosomal Dominant
Bi-allelic pathogenic variations in DNAJB11 cause Ivemark II syndrome, a renal-hepatic-pancreatic dysplasia.
Ganetespib limits ciliation and cystogenesis in autosomal-dominant polycystic kidney disease (ADPKD).
Inhibiting heat shock protein 90 (HSP90) limits the formation of liver cysts induced by conditional deletion of Pkd1 in mice.
Inhibiting the HSP90 chaperone slows cyst growth in a mouse model of autosomal dominant polycystic kidney disease.
Therapeutic targeting of BET bromodomain protein, Brd4, delays cyst growth in ADPKD.
Polycystic Ovary Syndrome
Effect of Hsp27 on early embryonic development in the mouse.
Impaired heat shock protein 72 expression in women with polycystic ovary syndrome following a supervised exercise programme.
Serum Heat Shock Protein 70 Concentration in Relation to Polycystic Ovary Syndrome in a Non-Obese Chinese Population.
Stress-induced activation of ovarian heat shock protein 90 in a rat model of polycystic ovary syndrome.
The Role of Heat Shock Protein 90B1 in Patients with Polycystic Ovary Syndrome.
Polycythemia Vera
HSP90 is a therapeutic target in JAK2-dependent myeloproliferative neoplasms in mice and humans.
Proteomic analysis reveals heat shock protein 70 has a key role in polycythemia Vera.
Polymyalgia Rheumatica
Serum levels of antibodies to Chlamydia pneumoniae and human HSP60 in giant cell arteritis patients.
Polymyositis
A dual role for HSP90 and HSP70 in the inflammatory myopathies: from muscle fiber protection to active invasion by macrophages.
Autoantibodies to the heat-shock protein hsp90 in systemic lupus erythematosus.
Heat-shock protein 90 and ubiquitin: developmental regulation during myogenesis.
[Expression of the heat shock protein 70 in inflammatory myopathies]
Polyneuropathies
Heat shock protein 27 is associated with better nerve function and fewer signs of neuropathy.
Polyomavirus Infections
In vivo and in vitro association of hsc70 with polyomavirus capsid proteins.
Porcine Reproductive and Respiratory Syndrome
Inhibition of HSP90 attenuates porcine reproductive and respiratory syndrome virus production in vitro.
Regulation of iNOS-Derived ROS Generation by HSP90 and Cav-1 in Porcine Reproductive and Respiratory Syndrome Virus-Infected Swine Lung Injury.
Pre-Eclampsia
Analysis of Nitroso-Proteomes in Normotensive and Severe Preeclamptic Human Placentas.
Assessment of placental and maternal stress responses in patients with pregnancy related complications via monitoring of heat shock protein mRNA levels.
Association of elevated serum heat-shock protein 70 concentration with transient hypertension of pregnancy, preeclampsia and superimposed preeclampsia: a case-control study.
Changes in serum levels of heat shock protein 70 in preterm delivery and pre-eclampsia.
Circulating heat shock protein mRNA profile in gestational hypertension, pre-eclampsia & foetal growth restriction.
Consensus strategy in genes prioritization and combined bioinformatics analysis for preeclampsia pathogenesis.
Correction: Retraction: Heat Shock Protein 70 Expression Is Spatially Distributed in Human Placenta and Selectively Upregulated during Labor and Preeclampsia.
Differential proteomic analysis of highly purified placental cytotrophoblasts in preeclampsia demonstrates a state of increased oxidative stress and reduced cytotrophoblast antioxidant defense.
Enhancement of heat shock protein 70 attenuates inducible nitric oxide synthase in preeclampsia complicated with fetal growth restriction.
Genomic and proteomic investigation of preeclampsia.
GRP78 as a marker of pre-eclampsia: an exploratory study.
Heat shock protein 27 expression is spatially distributed in human placenta and selectively regulated during preeclampsia.
Heat shock protein 27 in the placentas of women with and without severe preeclampsia.
Heat shock protein 70 expression is spatially distributed in human placenta and selectively upregulated during labor and preeclampsia.
Heat shock protein 70 is not increased in women with severe preeclampsia.
Heat shock protein-70 and 4-hydroxy-2-nonenal adducts in human placental villous tissue of normotensive, preeclamptic and intrauterine growth restricted pregnancies.
High levels of heat shock protein 70 are associated with pro-inflammatory cytokines and may differentiate early- from late-onset preeclampsia.
HSPA1L rs1061581 polymorphism is associated with the risk of preeclampsia in Han Chinese women.
Increased serum heat-shock protein 70 levels reflect systemic inflammation, oxidative stress and hepatocellular injury in preeclampsia.
Increased superoxide generation and decreased stress protein Hsp90 expression in human umbilical cord vein endothelial cells (HUVECs) from pregnancies complicated by preeclampsia.
Is preeclampsia associated with higher frequency of HSP70 gene polymorphisms?
Mechanism of JNK signal regulation by placental HSP70 and HSP90 in endothelial cell during preeclampsia.
PP003. Heat shock protein 27 expression is spatially distributed in human placenta and selectively regulated during preeclampsia.
Quantification of Calcyclin and Heat Shock Protein 90 in Sera from Women with and without Preeclampsia by Mass Spectrometry.
Retraction: Heat Shock Protein 70 Expression Is Spatially Distributed in Human Placenta and Selectively Upregulated during Labor and Preeclampsia.
Role of prostate apoptosis response 4 in translocation of GRP78 from the endoplasmic reticulum to the cell surface of trophoblastic cells.
Serum heat shock protein 70 in preeclampsia and normal pregnancy: A systematic review and meta-analysis.
Serum heat shock protein 70 levels in relation to circulating cytokines, chemokines, adhesion molecules and angiogenic factors in women with preeclampsia.
Serum levels of heat shock protein 70 in patients with preeclampsia: a pilot-study.
Serum levels of miR-628-3p and miR-628-5p during the early pregnancy are increased in women who subsequently develop preeclampsia.
The role of albumin and endoplasmic reticulum in pathogenesis Preeclampsia. Changes of GRP78 and placental VEGF in preeclampsia.
The Role of Melatonin in Oxidative Stress, DNA Damage, Apoptosis and Angiogenesis in Fetal Eye under Preeclampsia and Melatonin Deficiency Stress.
[Effect of endoplasmic reticulum stress-responsive protein glucose-regulated protein 78, 94 and endoplasmic reticulum apoptosis factor caspase-12 in trophocyte on the pathogenesis of preeclampsia.]
Precursor Cell Lymphoblastic Leukemia-Lymphoma
17-DMAG disrupted the autophagy flux leading to the apoptosis of acute lymphoblastic leukemia cells by inducing heat shock cognate protein 70.
Correction: Plasma Hsp90 Level as a Marker of Early Acute Lymphoblastic Leukemia Engraftment and Progression in Mice.
Differential expression levels of the heat shock protein 27 isoforms in pediatric normal, nonleukemic and common acute lymphoblastic leukemia B-cell precursors.
Diminished phosphorylation of a heat shock protein (HSP 27) in infant acute lymphoblastic leukemia.
Effect of heat shock protein-90 (HSP90) and vascular endothelial growth factor (VEGF) on survival in acute lymphoblastic leukemia: an immunohistochemical study.
Expression of heat-shock protein 90 in glucocorticoid-sensitive and -resistant childhood acute lymphoblastic leukaemia.
HLA complex-linked heat shock protein genes and childhood acute lymphoblastic leukemia susceptibility.
HSP90 inhibition leads to degradation of the TYK2 kinase and apoptotic cell death in T-cell acute lymphoblastic leukemia.
Hsp90 inhibitor BIIB021 enhances triptolide-induced apoptosis of human T-cell acute lymphoblastic leukemia cells in vitro mainly by disrupting p53-MDM2 balance.
HSP90 inhibitors decrease AID levels and activity in mice and in human cells.
Identification of heat shock protein 32 (Hsp32) as a novel target in acute lymphoblastic leukemia.
Induction chemotherapy reduces extracellular heat shock protein 72 levels, inflammation, lipoperoxidation and changes insulin sensitivity in children and adolescents newly diagnosed with acute lymphoblastic leukemia.
Plasma Hsp90 Level as a Marker of Early Acute Lymphoblastic Leukemia Engraftment and Progression in Mice.
Sensitization of multidrug-resistant human cancer cells to Hsp90 inhibitors by down-regulation of SIRT1.
Serum heat shock protein 90 as a future predictive biomarker in childhood acute lymphoblastic leukemia.
The synthetic heat shock protein 90 (Hsp90) inhibitor EC141 induces degradation of Bcr-Abl p190 protein and apoptosis of Ph-positive acute lymphoblastic leukemia cells.
[Effect of Heat Shock Protein 90 Inhibitor 17-DMAG on Proliferation and Apoptosis of Acute Lymphocytic Leukemia Cell Line Jurkat].
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
HSP90 inhibition leads to degradation of the TYK2 kinase and apoptotic cell death in T-cell acute lymphoblastic leukemia.
Interconnecting molecular pathways in the pathogenesis and drug sensitivity of T-cell acute lymphoblastic leukemia.
Oncogenic hijacking of the stress response machinery in T cell acute lymphoblastic leukemia.
PRC2 loss induces chemoresistance by repressing apoptosis in T cell acute lymphoblastic leukemia.
Stabilization of Notch1 by the Hsp90 Chaperon is Crucial for T Cell Leukemogenesis.
Pregnancy, Ectopic
Deoxyribonucleic acid of Chlamydia trachomatis in fresh tissue from the Fallopian tubes of patients with ectopic pregnancy.
Differential human serologic response to two 60,000 molecular weight Chlamydia trachomatis antigens.
Serological responses of patients with ectopic pregnancy to epitopes of the Chlamydia trachomatis 60 kDa heat shock protein.
Seropositivity for the human heat shock protein (Hsp)60 accompanying seropositivity for Chlamydia trachomatis is less prevalent among tubal ectopic pregnancy cases than individuals with normal reproductive history.
Serum interleukin-1?, interleukin-8 and anti-heat shock 60 Chlamydia trachomatis antibodies as markers of ectopic pregnancy.
Premature Birth
Correction: Whole exome sequencing reveals HSPA1L as a genetic risk factor for spontaneous preterm birth.
Heat shock proteins and heat shock protein-antibody complexes in placental tissues.
Integrative genetic, genomic and transcriptomic analysis of heat shock protein and nuclear hormone receptor gene associations with spontaneous preterm birth.
Preterm birth and/or low birth weight are associated with periodontal disease and the increased placental immunohistochemical expression of inflammatory markers.
The Preventive Effects of Quercetin on Preterm Birth Based on Network Pharmacology and Bioinformatics.
Whole exome sequencing reveals HSPA1L as a genetic risk factor for spontaneous preterm birth.
Presbyopia
Presbyopia and heat: changes associated with aging of the human lens suggest a functional role for the small heat shock protein, alpha-crystallin, in maintaining lens flexibility.
Pressure Ulcer
Non-invasive detection of local tissue responses to predict pressure ulcer development in mouse models.
Prediction of healing in Category I pressure ulcers by skin blotting with plasminogen activator inhibitor 1, interleukin-1?, vascular endothelial growth factor C, and heat shock protein 90?: A pilot study.
[The expressions of endoplasmic reticulum molecular chaperone proteins in pressure ulcer on the different stage of ischemic injury].
Primary Graft Dysfunction
HSP90 Inhibitor Improves Lung Protection in Porcine Model of Donation after Circulatory Arrest.
Primary Myelofibrosis
Heat shock protein 27 (HSP27/HSPB1) expression is increased in patients with primary and secondary myelofibrosis and may be affecting their survival.
Mutant calreticulin knockin mice develop thrombocytosis and myelofibrosis without a stem cell self-renewal advantage.
The role of calreticulin mutations in myeloproliferative neoplasms.
Prion Diseases
A designer molecular chaperone against transmissible spongiform encephalopathy slows disease progression in mice and macaques.
Creutzfeldt-Jakob disease: heat shock protein 70 mRNA levels in mononuclear blood cells and clinical study.
Heat shock protein 70 selectively mediates the degradation of cytosolic PrPs and restores the cytosolic PrP-induced cytotoxicity via a molecular interaction.
Prion disease is accelerated in mice lacking stress-induced heat shock protein 70 (HSP70).
The 14-3-3 protein forms a molecular complex with heat shock protein Hsp60 and cellular prion protein.
The chaperone Grp78 in protein folding disorders of the nervous system.
The Endoplasmic Reticulum Chaperone GRP78/BiP Modulates Prion Propagation in vitro and in vivo.
The possible role of protein X, a putative auxiliary factor in pathological prion replication, in regulating a physiological endoproteolytic cleavage of cellular prion protein.
Prostatic Hyperplasia
Cytoprotective mitochondrial chaperone TRAP-1 as a novel molecular target in localized and metastatic prostate cancer.
Expression of Heat Shock Protein 27 in Benign Prostatic Hyperplasia with Chronic Inflammation.
Heat Shock Protein 90 is Associated with Hyperplasia and Neoplastic Transformation of Canine Prostatic Epithelial Cells.
Immunohistochemical expression of heat shock proteins, p63 and androgen receptor in benign prostatic hyperplasia and prostatic carcinoma in the dog.
Molecular classification of benign prostatic hyperplasia: A gene expression profiling study in a rat model.
Response to sublethal heat treatment of prostatic tumor cells and of prostatic tumor infiltrating T-cells.
Prostatic Intraepithelial Neoplasia
Cytoprotective mitochondrial chaperone TRAP-1 as a novel molecular target in localized and metastatic prostate cancer.
Prostatic Neoplasms
17-Allylamino-17-demethoxygeldanamycin induces the degradation of androgen receptor and HER-2/neu and inhibits the growth of prostate cancer xenografts.
17-DMCHAG, a new geldanamycin derivative, inhibits prostate cancer cells through Hsp90 inhibition and survivin downregulation.
?-Lapachone Induces NQO1- and Oxidative Stress-Dependent Hsp90 Cleavage and Inhibits Tumor Growth and Angiogenesis.
A Novel Class of Hsp90 C-Terminal Modulators Have Pre-Clinical Efficacy in Prostate Tumor Cells Without Induction of a Heat Shock Response.
A novel HSP90 inhibitor delays castrate resistant prostate cancer without altering serum PSA levels and inhibits osteoclastogenesis.
A novel mechanism for chaperone-mediated telomerase regulation during prostate cancer progression.
A phase I dose-escalation study of apatorsen (OGX-427), an antisense inhibitor targeting heat shock protein 27 (Hsp27), in patients with castration-resistant prostate cancer and other advanced cancers.
A phase II trial of ganetespib, a heat shock protein 90 Hsp90) inhibitor, in patients with docetaxel-pretreated metastatic castrate-resistant prostate cancer (CRPC)-a prostate cancer clinical trials consortium (PCCTC) study.
A randomized phase 2 study of a HSP27 targeting antisense, apatorsen with prednisone versus prednisone alone, in patients with metastatic castration resistant prostate cancer.
Abrogation of heat-shock protein (HSP)70 expression induced cell growth inhibition and apoptosis in human androgen-independent prostate cancer cell line PC-3m.
Acetylation-dependent regulation of TPD52 isoform 1 modulates chaperone-mediated autophagy in prostate cancer.
Activated ?2-Macroglobulin Binding to Human Prostate Cancer Cells Triggers Insulin-like Responses.
Activation and cross-talk between Akt, NF-kappaB, and unfolded protein response signaling in 1-LN prostate cancer cells consequent to ligation of cell surface-associated GRP78.
Akt-regulated pathways in prostate cancer.
Amide-tethered quinoline-resorcinol conjugates as a new class of HSP90 inhibitors suppressing the growth of prostate cancer cells.
Androgen receptor signaling in hepatocellular carcinoma and pancreatic cancers.
Androgens modulate autophagy and cell death via regulation of the endoplasmic reticulum chaperone glucose-regulated protein 78/BiP in prostate cancer cells.
Apoptosis induction by 1alpha,25-dihydroxyvitamin D3 in prostate cancer.
Association between DNA methylation of HSPB1 and death in low Gleason score prostate cancer.
Association of HSP70-hom genetic variant with prostate cancer risk.
Autoantibodies against cell surface GRP78 promote tumor growth in a murine model of melanoma.
Autoantibodies against the cell surface-associated chaperone GRP78 stimulate tumor growth via tissue factor.
Beyond androgen deprivation: ancillary integrative strategies for targeting the androgen receptor addiction of prostate cancer.
Bifunctional Au-templated RNA nanoparticles enable direct cell uptake detection and GRP75 knockdown in prostate cancer.
Binding of activated alpha2-macroglobulin to its cell surface receptor GRP78 in 1-LN prostate cancer cells regulates PAK-2-dependent activation of LIMK.
Binding of anti-GRP78 autoantibodies to cell surface GRP78 increases tissue factor procoagulant activity via the release of calcium from endoplasmic reticulum stores.
Bruceantin targets HSP90 to overcome resistance to hormone therapy in castration-resistant prostate cancer.
Cabazitaxel inhibits prostate cancer cell growth by inhibition of androgen receptor and heat shock protein expression.
Cancer cells resistant to therapy promote cell surface relocalization of GRP78 which complexes with PI3K and enhances PI(3,4,5)P3 production.
Castration-Induced Downregulation of SPARC in Stromal Cells Drives Neuroendocrine Differentiation of Prostate Cancer.
Cell Stress Induced Stressome Release Including Damaged Membrane Vesicles and Extracellular HSP90 by Prostate Cancer Cells.
Cell surface heat shock protein 90 modulates prostate cancer cell adhesion and invasion through the integrin-?1/focal adhesion kinase/c-Src signaling pathway.
Characterization of a novel novobiocin analogue as a putative C-terminal inhibitor of heat shock protein 90 in prostate cancer cells.
Clusterin Inhibition using OGX-011 Synergistically Enhances Hsp90 Inhibitor Activity by Suppressing the Heat Shock Response in Castrate Resistant Prostate Cancer.
Co-downregulation of GRP78 and GRP94 Induces Apoptosis and Inhibits Migration in Prostate Cancer Cells.
Co-targeting AR and HSP90 suppresses prostate cancer cell growth and prevents resistance mechanisms.
Codelivery of GRP78 siRNA and docetaxel via RGD-PEG-DSPE/DOPA/CaP nanoparticles for the treatment of castration-resistant prostate cancer.
Colocalisation of CD9 and mortalin in CD9-induced mitotic catastrophe in human prostate cancer cells.
Combined ?-methylacyl-CoA racemase inhibition and docetaxel treatment reduce cell proliferation and decrease expression of heat shock protein 27 in androgen receptor-variant-7-positive prostate cancer cells.
Constitutively-active androgen receptor variants function independently of the HSP90 chaperone but do not confer resistance to HSP90 inhibitors.
Cooperative Interactions between Androgen Receptor (AR) and Heat-Shock Protein 27 Facilitate AR Transcriptional Activity.
Cotargeting HSP90 and Its Client Proteins for Treatment of Prostate Cancer.
CRIPTO and its signaling partner GRP78 drive the metastatic phenotype in human osteotropic prostate cancer.
Cross-presentation of the oncofoetal tumor antigen 5T4 from irradiated prostate cancer cells - a key role for heat shock protein 70 and receptor CD91.
Cytochrome P450 17A1 Inhibitor Abiraterone Acetate Counteracts the Heat Shock Protein 27's Cell Survival Properties in Prostate Cancer Cells.
Cytoprotective mitochondrial chaperone TRAP-1 as a novel molecular target in localized and metastatic prostate cancer.
Delivery of HSP90 Inhibitor Using Water Soluble Polymeric Conjugates with High Drug Payload.
Development and characterization of a novel C-terminal inhibitor of Hsp90 in androgen dependent and independent prostate cancer cells.
Differences in glycosylation patterns of heat shock protein, gp96: implications for prostate cancer prevention.
Differential expression of Annexin 2, SPINK1, and Hsp60 predict progression of prostate cancer through bifurcated WHO Gleason score categories in African American men.
Discovery of a novel unfolded protein response phenotype of cancer stem/progenitor cells from the bone marrow of breast cancer patients.
Disruption of an hTERT-mTOR-RAPTOR protein complex by a phytochemical perillyl alcohol and rapamycin.
Down-regulation of mammalian sterile 20-like kinase 1 by heat shock protein 70 mediates cisplatin resistance in prostate cancer cells.
Downregulation of androgen receptors by NaAsO2 via inhibition of AKT-NF-?B and HSP90 in castration resistant prostate cancer.
Dysregulated fibronectin trafficking by Hsp90 inhibition restricts prostate cancer cell invasion.
Effect of the heat shock protein HSP27 on androgen receptor expression and function in prostate cancer cells.
Effect of the hsp90 inhibitor geldanamycin on androgen response of prostate cancer under hypoxic conditions.
Effects of dihydroartemisinin on HSP70 expression in human prostate cancer PC-3 cells.
Effects of quercetin on the heat-induced cytotoxicity of prostate cancer cells.
Efficient Delivery of Sticky siRNA and Potent Gene Silencing in a Prostate Cancer Model Using a Generation 5 Triethanolamine-Core PAMAM Dendrimer.
Emphasizing on heat shock protein 90's utility in head and neck squamous cell carcinoma treatment.
Enhanced expression of heat shock protein 27 following neoadjuvant hormonal therapy is associated with poor clinical outcome in patients undergoing radical prostatectomy for prostate cancer.
Estrogen receptor gene expression and its relation to the estrogen-inducible HSP27 heat shock protein in hormone refractory prostate cancer.
Evaluation of the radiosensitizing potency of chemotherapeutic agents in prostate cancer cells.
Evidence for efficacy of new Hsp90 inhibitors revealed by ex vivo culture of human prostate tumors.
Expression levels of heat shock protein 27 and cellular FLICE-like inhibitory protein in prostate cancer correlate with Gleason score sum and pathologic stage.
Expression of Heat Shock Protein 27 in Benign Prostatic Hyperplasia with Chronic Inflammation.
Expression of heat shock protein 27 in prostate cancer cell lines according to the extent of malignancy and doxazosin treatment.
Expression of interleukin-6 is downregulated by 17-(allylamino)-17-demethoxygeldanamycin in human prostatic carcinoma cells.
Expression of major heat shock proteins in prostate cancer: correlation with clinicopathological outcomes in patients undergoing radical prostatectomy.
Expression of stress response protein Grp78 is associated with the development of castration-resistant prostate cancer.
Expression of TRAP1 predicts poor survival of malignant glioma patients.
Fatty Acid Oxidation Is an Adaptive Survival Pathway Induced in Prostate Tumors by HSP90 Inhibition.
Finding the place of histone deacetylase inhibitors in prostate cancer therapy.
FKBP51 promotes assembly of the Hsp90 chaperone complex and regulates androgen receptor signaling in prostate cancer cells.
Formulation and in vitro efficacy of liposomes containing the Hsp90 inhibitor 6BrCaQ in prostate cancer cells.
Genistein down-regulates androgen receptor by modulating HDAC6-Hsp90 chaperone function.
Genistein inhibits matrix metalloproteinase type 2 activation and prostate cancer cell invasion by blocking the transforming growth factor beta-mediated activation of mitogen-activated protein kinase-activated protein kinase 2-27-kDa heat shock protein pathway.
Glucose-regulated protein 78 mediates hormone-independent prostate cancer progression and metastasis through maspin and COX-2 expression.
Glucose-regulated protein 78 mediates the anticancer efficacy of shikonin in hormone-refractory prostate cancer cells.
Glucose-regulated protein GRP78 is up-regulated in prostate cancer and correlates with recurrence and survival.
GRP78 and ?2-macroglobulin are new promising targets for metastatic castrate-resistant prostate cancer treatment.
GRP78 and Cripto form a complex at the cell surface and collaborate to inhibit transforming growth factor beta signaling and enhance cell growth.
GRP78 modulates cell adhesion markers in prostate Cancer and multiple myeloma cell lines.
GRP78 Participates in PCA3-regulated Prostate Cancer Progression.
GRP78 regulates clusterin stability, retrotranslocation and mitochondrial localization under ER stress in prostate cancer.
GRP78 up-regulation is associated with androgen receptor status, Hsp70-Hsp90 client proteins and castrate-resistant prostate cancer.
GRP78-targeted nanotherapy against castrate-resistant prostate cancer cells expressing membrane GRP78.
HDAC6 Regulates Androgen Receptor Hypersensitivity and Nuclear Localization via Modulating Hsp90 Acetylation in Castration-Resistant Prostate Cancer.
Heat shock protein 27 confers resistance to androgen ablation and chemotherapy in prostate cancer cells through eIF4E.
Heat shock protein 27 increases after androgen ablation and plays a cytoprotective role in hormone-refractory prostate cancer.
Heat shock protein 27 mediates repression of androgen receptor function by protein kinase D1 in prostate cancer cells.
Heat shock protein 27 regulates human prostate cancer cell motility and metastatic progression.
Heat shock protein 70 inhibitors suppress androgen receptor expression in LNCaP95 prostate cancer cells.
Heat shock protein 90 (Hsp90) chaperone complex inhibitor, radicicol, potentiated radiation-induced cell killing in a hormone-sensitive prostate cancer cell line through degradation of the androgen receptor.
Heat shock protein 90 inhibition by 17-allylamino-17- demethoxygeldanamycin: a novel therapeutic approach for treating hormone-refractory prostate cancer.
Heat shock protein expression independently predicts clinical outcome in prostate cancer.
Heat-induced cellular damage and tolerance in combination with adriamycin for the PC-3 prostate cancer cell line: relationships with cytotoxicity, reactive oxygen species and heat shock protein 70 expression.
High-throughput screens identify HSP90 inhibitors as potent therapeutics that target inter-related growth and survival pathways in advanced prostate cancer.
HPMA Copolymer-Aminohexylgeldanamycin Conjugates Targeting Cell Surface Expressed GRP78 in Prostate Cancer.
Hsp-27 expression at diagnosis predicts poor clinical outcome in prostate cancer independent of ETS-gene rearrangement.
Hsp27 regulates EGF/?-catenin mediated epithelial to mesenchymal transition in prostate cancer.
Hsp60 and IL-8 axis promotes apoptosis resistance in cancer.
HSP90 and HSP70 are essential for stabilization and activation of the WASF3 metastasis promoting protein.
Hsp90 as a therapeutic target in prostate cancer.
Hsp90 inhibitor 17-AAG inhibits progression of LuCaP35 xenograft prostate tumors to castration resistance.
HSP90 Inhibitor Encapsulated Photo-Theranostic Nanoparticles for Synergistic Combination Cancer Therapy.
Hsp90: Still a viable target in prostate cancer.
Hybrid Enzalutamide Derivatives with Histone Deacetylase Inhibitor Activity Decrease Heat Shock Protein 90 and Androgen Receptor Levels and Inhibit Viability in Enzalutamide-Resistant C4-2 Prostate Cancer Cells.
Identification of Novel Response and Predictive Biomarkers to Hsp90 Inhibitors Through Proteomic Profiling of Patient-derived Prostate Tumor Explants.
Immediate and transient phosphorylation of the heat shock protein 27 initiates chemoresistance in prostate cancer cells.
Immunization with a recombinant GnRH vaccine conjugated to heat shock protein 65 inhibits tumor growth in orthotopic prostate cancer mouse model.
Immunohistochemical expression of Hsp60 correlates with tumor progression and hormone resistance in prostate cancer.
Induction of nitric oxide synthase-dependent telomere shortening after functional inhibition of Hsp90 in human tumor cells.
Inhibition of Androgen Receptor Expression with Small Interfering RNA Enhances Cancer Cell Apoptosis by Suppressing Survival Factors in Androgen Insensitive, Late Stage LNCaP Cells.
Inhibition of constitutive and cxc-chemokine-induced NF-kappaB activity potentiates ansamycin-based HSP90-inhibitor cytotoxicity in castrate-resistant prostate cancer cells.
Inhibition of Hsp90 activates osteoclast c-Src signaling and promotes growth of prostate carcinoma cells in bone.
Inhibition of Hsp90 augments docetaxel therapy in castrate resistant prostate cancer.
Inhibition of mouse RM-1 prostate cancer and B16F10 melanoma by the fusion protein of HSP65 & STEAP1 186-193.
Inhibition of NF-kappaB1 and NF-kappaB2 activation in prostate cancer cells treated with antibody against the carboxyl terminal domain of GRP78: effect of p53 upregulation.
Insulin-like growth factor-I induces CLU expression through Twist1 to promote prostate cancer growth.
Intercellular transmission of the unfolded protein response promotes survival and drug resistance in cancer cells.
Intratumor injection of the Hsp90 inhibitor 17AAG decreases tumor growth and induces apoptosis in a prostate cancer xenograft model.
Knockdown of glucose-regulated protein 78/binding immunoglobulin heavy chain protein expression by asymmetric small interfering RNA induces apoptosis in prostate cancer cells and attenuates migratory capability.
KU675, a Concomitant Heat-Shock Protein Inhibitor of Hsp90 and Hsc70 that Manifests Isoform Selectivity for Hsp90? in Prostate Cancer Cells.
Ligation of cancer cell surface GRP78 with antibodies directed against its COOH-terminal domain up-regulates p53 activity and promotes apoptosis.
Ligation of cell surface GRP78 with antibody directed against the COOH-terminal domain of GRP78 suppresses Ras/MAPK and PI 3-kinase/AKT signaling while promoting caspase activation in human prostate cancer cells.
Ligation of prostate cancer cell surface GRP78 activates a proproliferative and antiapoptotic feedback loop: a role for secreted prostate-specific antigen.
LncRNA AC245100.4 binds HSP90 to promote the proliferation of prostate cancer.
Local radiotherapy increases the level of autoantibodies to ribosomal P0 protein but not to heat shock proteins, extracellular matrix molecules and EGFR/ErbB2 receptors in prostate cancer patients.
Loss of cell surface TFII-I promotes apoptosis in prostate cancer cells stimulated with activated ?? -macroglobulin.
Low intensity focused ultrasound (LOFU) modulates unfolded protein response and sensitizes prostate cancer to 17AAG.
Management of Hsp90-Dependent Protein Folding by Small Molecules Targeting the Aha1 Co-Chaperone.
Marchantin M Induces Apoptosis of Prostate Cancer Cells Through Endoplasmic Reticulum Stress.
Mechanisms of disease: the role of heat-shock protein 90 in genitourinary malignancy.
Membrane Interactome of a Recombinant Fragment of Human Surfactant Protein D Reveals GRP78 as a Novel Binding Partner in PC3, a Metastatic Prostate Cancer Cell Line.
miR-30d, miR-181a and miR-199a-5p cooperatively suppress the endoplasmic reticulum chaperone and signaling regulator GRP78 in cancer.
Mitochondrial dysfunction-mediated apoptosis resistance associates with defective heat shock protein response in African-American men with prostate cancer.
Mitochondrial Hsp90 chaperones as novel molecular targets in prostate cancer.
Modified biphenyl Hsp90 C-terminal inhibitors for the treatment of cancer.
Modulation of heat-induced cell death in PC-3 prostate cancer cells by the antioxidant inhibitor diethyldithiocarbamate.
Modulation of the unfolded protein response by GRP78 in prostate cancer.
Modulation of the unfolded protein response in prostate cancer cells by antibody-directed against the carboxyl-terminal domain of GRP78.
Moving Beyond the Androgen Receptor (AR): Targeting AR-Interacting Proteins to Treat Prostate Cancer.
Multi-drug loaded micelles delivering chemotherapy and targeted therapies directed against HSP90 and the PI3K/AKT/mTOR pathway in prostate cancer.
Multicenter Phase II Trial of the Heat Shock Protein 90 Inhibitor, Retaspimycin Hydrochloride (IPI-504), in Patients With Castration-resistant Prostate Cancer.
Muscadine grape skin extract inhibits prostate cancer cells by inducing cell-cycle arrest, and decreasing migration through heat shock protein 40.
Nitroreductase-based therapy of prostate cancer, enhanced by raising expression of heat shock protein 70, acts through increased anti-tumour immunity.
NKX3.1 Localization to Mitochondria Suppresses Prostate Cancer Initiation.
Non-invasive PET imaging of EGFR degradation induced by a heat shock protein 90 inhibitor.
Novel Hsp90 inhibitor NVP-AUY922 radiosensitizes prostate cancer cells.
Nucleoside-Lipid-Based Nanoparticles for Phenazine Delivery: A New Therapeutic Strategy to Disrupt Hsp27-eIF4E Interaction in Castration Resistant Prostate Cancer.
Optimizing heat shock protein expression induced by prostate cancer laser therapy through predictive computational models.
p53-dependent induction of heat shock protein 27 (HSP27) expression.
PACE4 regulates apoptosis in human prostate cancer cells via endoplasmic reticulum stress and mitochondrial signaling pathways.
Pharmacodynamic and Clinical Results from a Phase I/II Study of the HSP90 Inhibitor Onalespib in Combination with Abiraterone Acetate in Prostate Cancer.
Phosphorylation of HSP90 by protein kinase A is essential for the nuclear translocation of androgen receptor.
Pifithrin-?, an inhibitor of heat-shock protein 70, can increase the antitumor effects of hyperthermia against human prostate cancer cells.
PIM-1-specific mAb suppresses human and mouse tumor growth by decreasing PIM-1 levels, reducing Akt phosphorylation, and activating apoptosis.
Plasma levels of heat shock protein 70 in patients with prostate cancer: a potential biomarker for prostate cancer.
Potent activity of the Hsp90 inhibitor ganetespib in prostate cancer cells irrespective of androgen receptor status or variant receptor expression.
Preclinical characterization of mitochondria-targeted small molecule hsp90 inhibitors, gamitrinibs, in advanced prostate cancer.
Preventive and therapeutic effect of tumor derived heat shock protein, gp96, in an experimental prostate cancer model.
Progression of the role of CRYAB in signaling pathways and cancers.
Prostate cancer serum biomarker discovery through proteomic analysis of alpha-2 macroglobulin protein complexes.
Prostate cancer: Ex vivo efficacy of heat shock protein 90 inhibitors.
Proteomic comparison of prostate cancer cell lines LNCaP-FGC and LNCaP-r reveals heatshock protein 60 as a marker for prostate malignancy.
Proton MRS detects metabolic changes in hormone sensitive and resistant human prostate cancer models CWR22 and CWR22r.
Pten null prostate tumorigenesis and AKT activation are blocked by targeted knockout of ER chaperone GRP78/BiP in prostate epithelium.
PXD101 potentiates hormonal therapy and prevents the onset of castration-resistant phenotype modulating androgen receptor, HSP90 and CRM1 in preclinical models of prostate cancer.
Radioactive iodine labeling of monoclonal antibody against Hsp90? and its use in diagnostic imaging in prostate cancer xenograft model.
Re: targeting the regulation of androgen receptor signaling by the heat shock protein 90 cochaperone FKBP52 in prostate cancer cells.
Receptor-recognized ??-macroglobulin binds to cell surface-associated GRP78 and activates mTORC1 and mTORC2 signaling in prostate cancer cells.
Regulation of heat shock protein 70-1 expression by androgen receptor and its signaling in human prostate cancer cells.
Role of prostate apoptosis response 4 in translocation of GRP78 from the endoplasmic reticulum to the cell surface of trophoblastic cells.
Second-Generation HSP90 Inhibitor Onalespib Blocks mRNA Splicing of Androgen Receptor Variant 7 in Prostate Cancer Cells.
Secreted heat shock protein 90 promotes prostate cancer stem cell heterogeneity.
Secreted Hsp90 is a novel regulator of the epithelial to mesenchymal transition (EMT) in prostate cancer.
Selection and identification of ligand peptides targeting a model of castrate-resistant osteogenic prostate cancer and their receptors.
Shh Overexpression Is Correlated with GRP78 and AR Expression in Primary Prostate Cancer: Clinicopathological Features and Outcomes in a Chinese Cohort.
Silencing of survivin gene by small interfering RNAs produces supra-additive growth suppression in combination with 17-allylamino-17-demethoxygeldanamycin in human prostate cancer cells.
Stress protein GRP78 prevents apoptosis induced by calcium ionophore, ionomycin, but not by glycosylation inhibitor, tunicamycin, in human prostate cancer cells.
Sulforaphane destabilizes the androgen receptor in prostate cancer cells by inactivating histone deacetylase 6.
Suppression of Heat Shock Protein 27 Using OGX-427 Induces Endoplasmic Reticulum Stress and Potentiates Heat Shock Protein 90 Inhibitors to Delay Castrate-resistant Prostate Cancer.
Synergistic enhancement of cancer therapy using a combination of heat shock protein targeted HPMA copolymer-drug conjugates and gold nanorod induced hyperthermia.
Systemic GLIPR1-?TM protein as a novel therapeutic approach for prostate cancer.
Targeted inhibition of mitochondrial Hsp90 suppresses localised and metastatic prostate cancer growth in a genetic mouse model of disease.
Targeting prostate cancer cells with enzalutamide-HDAC inhibitor hybrid drug 2-75.
Targeting TCTP as a New Therapeutic Strategy in Castration-resistant Prostate Cancer.
Targeting the regulation of androgen receptor signaling by the heat shock protein 90 cochaperone FKBP52 in prostate cancer cells.
The 70 kilodalton heat shock protein is an inhibitor of apoptosis in prostate cancer.
The androgen receptor antagonist enzalutamide induces apoptosis, dysregulates the heat shock protein system, and diminishes the androgen receptor and estrogen receptor ?1 expression in prostate cancer cells.
The co-chaperone p23 promotes prostate cancer motility and metastasis.
The dietary bioflavonoid, quercetin, selectively induces apoptosis of prostate cancer cells by down-regulating the expression of heat shock protein 90.
The Escherichia coli Subtilase Cytotoxin A Subunit Specifically Cleaves Cell-Surface GRP78 and Abolishes COOH-Terminal-Dependent Signaling.
The heat shock protein 70 inhibitor VER155008 suppresses the expression of HSP27, HOP and HSP90? and the androgen receptor, induces apoptosis, and attenuates prostate cancer cell growth.
The heat shock protein 90 inhibitor, (-)-epigallocatechin gallate, has anticancer activity in a novel human prostate cancer progression model.
The HSP90 inhibitor 17-PAG effectively inhibits the proliferation and migration of androgen-independent prostate cancer cells.
The Hsp90 inhibitor, 17-AAG, prevents the ligand-independent nuclear localization of androgen receptor in refractory prostate cancer cells.
The monomeric receptor binding domain of tetrameric ?2-macroglobulin binds to cell surface GRP78 triggering equivalent activation of signaling cascades.
The promise of heat shock protein inhibitors in the treatment of castration resistant prostate cancer.
The role of heat shock protein 70 in the thermoresistance of prostate cancer cell line spheroids.
The Role of Prostate Apoptosis Response-4 (Par-4) in Mycobacterium tuberculosis Infected Macrophages.
Thermally Induced Apoptosis, Necrosis, and Heat Shock Protein Expression in 3D Culture.
Transcription factor TFII-I causes transcriptional upregulation of GRP78 synthesis in prostate cancer cells.
Transgenic Expression of the Mitochondrial Chaperone TNFR-associated Protein 1 (TRAP1) Accelerates Prostate Cancer Development.
TRAP1 Regulates Proliferation, Mitochondrial Function and has Prognostic Significance in NSCLC.
TRIB1 Supports Prostate Tumorigenesis and Tumor-Propagating Cell Survival by Regulation of Endoplasmic Reticulum Chaperone Expression.
Tumor secreted Hsp90 subverts Polycomb function to drive prostate tumor growth and invasion.
Ultrasound Targeted Microbubble Destruction for Novel Dual Targeting of HSP72 and HSC70 in Prostate Cancer.
Ultrasound-targeted microbubble destruction combined with dual targeting of HSP72 and HSC70 inhibits HSP90 function and induces extensive tumor-speci?c apoptosis.
Unleashing the full potential of Hsp90 inhibitors as cancer therapeutics through simultaneous inactivation of Hsp90, Grp94, and TRAP1.
Words of wisdom. Re: Targeting the regulation of androgen receptor signaling by the heat shock protein 90 cochaperone FKBP52 in prostate cancer cells.
[Antisense oligodeoxynucleotide therapy for castration-resistant prostate cancer].
[Effect of quercetin on heat shock protein 27 expression in prostate cancer cells].
[FAK/c-Src signaling pathway mediates the expression of cell surface HSP90 in cultured human prostate cancer cells and its association with their invasive capability].
Prostatitis
Chlamydia trachomatis Infection Is Related to Poor Semen Quality in Young Prostatitis Patients.
Heat shock protein 9-mediated inflammation reaction in patients with chronic prostatitis with erectile dysfunction.
Heat-shock protein 70 expression in the seminal plasma of patients with chronic bacterial prostatitis and chronic prostatitis/chronic pelvic pain syndrome.
The diagnostic value of urine heat shock protein 70 and prostatic exosomal protein in chronic prostatitis.
[Levels of cytokines and heat-shock protein 70 in the seminal plasma of patients with chronic bacterial prostatitis and chronic prostatitis/chronic pelvic pain syndrome].
protein kinase c deficiency
Loss of PKC-delta alters cardiac metabolism.
Proteinuria
Correlations of podocyte injury with glucose regulated protein 78 expression and proteinuria in patients with diabetic nephropathy.
Endoplasmic Reticulum Stress Predicts Clinical Response to Cyclosporine Treatment in Primary Membranous Nephropathy.
Heat shock protein 60 is released in immune-mediated glomerulonephritis and aggravates disease: in vivo evidence for an immunologic danger signal.
Mizoribine corrects defective nephrin biogenesis by restoring intracellular energy balance.
The nephroprotection exerted by curcumin in maleate-induced renal damage is associated with decreased mitochondrial fission and autophagy.
Visualizing tubular lipid peroxidation in intact renal tissue in hypertensive rats.
Proteostasis Deficiencies
A model in which heat shock protein 90 targets protein-folding clefts: Rationale for a new approach to neuroprotective treatment of protein folding diseases.
Approaches for defining the Hsp90-dependent proteome.
ER chaperone-metal interactions: Links to protein folding disorders.
Hsp70:CHIP Ubiquitinates Dysfunctional but Not Native Neuronal NO Synthase.
Identification of bilateral changes in TID1 expression in the 6-OHDA rat model of Parkinson's disease.
Structure and function of the molecular chaperone Hsp104 from yeast.
The chaperone Grp78 in protein folding disorders of the nervous system.
protoporphyrin ferrochelatase deficiency
GRP75 overexpression rescues frataxin deficiency and mitochondrial phenotypes in Friedreich Ataxia cellular models.
Protozoan Infections
Heat shock protein 90 as a drug target against protozoan infections: Biochemical characterization of Hsp90 from Plasmodium falciparum, Trypanosoma evansi and evaluation of its inhibitor as a candidate drug.
Pruritus
Oxymatrine ameliorates imiquimod-induced psoriasis pruritus and inflammation through inhibiting heat shock protein 90 and heat shock protein 60 expression in keratinocytes.
Pseudorabies
Hsp90 is involved in pseudorabies virus virion assembly via stabilizing major capsid protein VP5.
Psoriasis
Activation of dendritic antigen-presenting cells expressing common heat shock protein receptor CD91 during induction of psoriasis.
Antibodies to mycobacterial 65-kDa heat shock protein and other immunodominant antigens in patients with psoriasis.
Antibodies to the 90 kDa heat shock protein in chronic plaque psoriasis.
Comparison of expression of heat-shock protein 60, Toll-like receptors 2 and 4, and T-cell receptor gammadelta in plaque and guttate psoriasis.
Debio 0932, A New Oral Hsp90 Inhibitor, Alleviates Psoriasis in a Xenograft Transplantation Model.
Effect of alterations in apoptotic pathway on development of metabolic syndrome in patients with psoriasis vulgaris.
Effects of luteolin on treatment of psoriasis by repressing HSP90.
Expression of heat shock protein 72 on peripheral blood mononuclear cells from patients with pustulosis palmaris et plantaris.
Ezrin, maspin, peroxiredoxin 2, and heat shock protein 27: potential targets of a streptococcal-induced autoimmune response in psoriasis.
Hsp72 antigen expression in the proliferative compartment of involved psoriatic epidermis.
Increased expression of heat shock protein 90 in keratinocytes and mast cells in patients with psoriasis.
Linking phenotypes and modes of action through high-content screen fingerprints.
Oxymatrine ameliorates imiquimod-induced psoriasis pruritus and inflammation through inhibiting heat shock protein 90 and heat shock protein 60 expression in keratinocytes.
Relationships between the onset of pustulosis palmaris et plantaris, periodontitis and bacterial heat shock proteins.
Structure-based drug designing and identification of Woodfordia fruticosa inhibitors targeted against heat shock protein (HSP70-1) as suppressor for Imiquimod-induced psoriasis like skin inflammation in mice model.
Structure-Based Drug Designing and Simulation Studies for Finding Novel Inhibitors of Heat Shock Protein (HSP70) as Suppressors for Psoriasis.
The HSP90 inhibitor RGRN-305 exhibits strong immunomodulatory effects in human keratinocytes.
The psoriasis-associated D10N variant of the adaptor Act1 with impaired regulation by the molecular chaperone hsp90.
Pterygium
?ypoxia-inducible factor-1?, von Hippel-Lindau protein, and heat shock protein expression in ophthalmic pterygium and normal conjunctiva.
Immunohistochemical detection of heat shock protein 27 and Ki-67 in human pterygium.
Immunohistochemical detection of Hsp90 and Ki-67 in pterygium.
Pulmonary Arterial Hypertension
Inhibition of heat shock protein 90 improves pulmonary arteriole remodeling in pulmonary arterial hypertension.
Lessons from Cancer: Subcellular Drug Targeting of Mitochondrial Hsp90 in Pulmonary Arterial Hypertension.
Mitochondrial HSP90 Accumulation Promotes Vascular Remodeling in Pulmonary Arterial Hypertension.
New Insights Into Heat Shock Protein 90 in the Pathogenesis of Pulmonary Arterial Hypertension.
Pulmonary Disease, Chronic Obstructive
Active ingredients targeting Nrf2 in the Mongolian medicine Qiwei Putao powder: Systematic pharmacological prediction and validation for chronic obstructive pulmonary disease treatment.
Analysis of the Plasma Proteome in COPD: Novel Low Abundance Proteins Reflect the Severity of Lung Remodeling.
Association of hsp70-2 (+1267A/G), hsp70-hom (+2437T/C), HMOX-1 (number of GT repeats) and TNF-alpha (+489G/A) polymorphisms with COPD in Croatian population.
Association of Plasma Heat Shock Protein 70 with Disease Severity, Smoking and Lung Function of Patients with Chronic Obstructive Pulmonary Disease.
Combination of Systemic Inflammatory Biomarkers in Assessment of Chronic Obstructive Pulmonary Disease: Diagnostic Performance and Identification of Networks and Clusters.
Convergent sets of data from in vivo and in vitro methods point to an active role of Hsp60 in chronic obstructive pulmonary disease pathogenesis.
Differential DAMP release was observed in the sputum of COPD, asthma and asthma-COPD overlap (ACO) patients.
Elevated HSP27, HSP70 and HSP90 alpha in chronic obstructive pulmonary disease: markers for immune activation and tissue destruction.
Endoplasmic reticulum chaperone GRP78 mediates cigarette smoke-induced necroptosis and injury in bronchial epithelium.
Fractional heat shock protein 27 urine excretion as a short-term predictor in acute exacerbation of chronic obstructive pulmonary disease.
Glucose-Regulated Protein 78 Autoantibodies Are Associated with Carotid Atherosclerosis in Chronic Obstructive Pulmonary Disease Patients.
Glutathione Peroxidase-1 Suppresses the Unfolded Protein Response upon Cigarette Smoke Exposure.
Heat shock protein 27 and cyclophilin A associate with the pathogenesis of COPD.
Heat shock protein 27 as a predictor of prognosis in patients admitted to hospital with acute COPD exacerbation.
Heat shock protein 70 gene polymorphisms in Han nationality of China with chronic obstructive pulmonary diseases.
HSP60 activity on human bronchial epithelial cells.
Hsp60 and Hsp10 down-regulation predicts bronchial epithelial carcinogenesis in smokers with chronic obstructive pulmonary disease.
HSP90AA1, ADRB2, TBL1XR1 and HSPB1 are chronic obstructive pulmonary disease-related genes that facilitate squamous cell lung cancer progression.
Increased expression of heat shock protein 70 in chronic obstructive pulmonary disease.
Increased HSP70 and TLR2 Gene Expression and Association of HSP70 rs6457452 Single Nucleotide Polymorphism with the Risk of Chronic Obstructive Pulmonary Disease in the Croatian Population.
Increased serum levels of HSP27 as a marker for incipient chronic obstructive pulmonary disease in young smokers.
Interleukin-1? drives the dysfunctional cross-talk of the airway epithelium and lung fibroblasts in COPD.
Nuclear HSP90 and HSP70 in COPD patients treated with formoterol or formoterol and corticosteroids.
Pathogen-associated molecular patterns and extracellular Hsp70 interplay in NLRP3 inflammasome activation in monocytic and bronchial epithelial cellular models of COPD exacerbations.
Protective Role of Genetic Variants in HSP90 Genes-Complex in COPD Secondary to Biomass-Burning Smoke Exposure and Non-Severe COPD Forms in Tobacco Smoking Subjects.
Reduced heat shock protein 70 in airway smooth muscle in patients with chronic obstructive pulmonary disease.
Secretion of the endoplasmic reticulum stress protein, GRP78, into the BALF is increased in cigarette smokers.
Serendipity and technical considerations for the measurement of serum heat shock protein HSP27 in patients with COPD and lung cancer.
Serum Heat Shock Protein Levels and the Relationship of Heat Shock Proteins with Various Parameters in Chronic Obstructive Pulmonary Disease Patients.
Steroid resistance in COPD is associated with impaired molecular chaperone Hsp90 expression by pro-inflammatory lymphocytes.
[DNA damage in lymphocytes from patients with chronic obstructive pulmonary disease]
[Relationship between dust exposure and chronic obstructive pulmonary diseases and heat shock protein 72 and 73 in lymphocytes among coal miners]
Pulmonary Edema
Changes in Expressions of HSP27, HSP70, and Soluble Glycoprotein in Heart Failure Rats Complicated with Pulmonary Edema and Correlations with Cardiopulmonary Functions.
Experimental chronic kidney disease attenuates ischemia-reperfusion injury in an ex vivo rat lung model.
High-altitude pulmonary edema can be prevented by heat shock protein 70-mediated hyperbaric oxygen preconditioning.
HSP-70-Mediated Hyperbaric Oxygen Reduces Brain and Pulmonary Edema and Cognitive Deficits in Rats in a Simulated High-Altitude Exposure.
Inhaled hydrogen sulfide protects against ventilator-induced lung injury.
Pulmonary Embolism
Assessment of heat shock proteins and endothelial dysfunction in acute pulmonary embolism.
Hsp90 mediates the balance of nitric oxide and superoxide anion in the lungs of rats with acute pulmonary thromboembolism.
Pulmonary Fibrosis
Alpha-defensin enhances expression of HSP47 and collagen-1 in human lung fibroblasts.
Antisense oligonucleotide inhibition of heat shock protein (HSP) 47 improves bleomycin-induced pulmonary fibrosis in rats.
Bleomycin-induced pulmonary fibrosis in rat is associated with increased expression of collagen-binding heat shock protein (HSP) 47.
Blockade of extracellular heat shock protein 90 alpha by 1G6-D7 attenuates pulmonary fibrosis through inhibiting ERK signaling.
FK506-Binding Protein 13 Expression Is Upregulated in Interstitial Lung Disease and Correlated with Clinical Severity. A Potentially Protective Role.
GRP78 and CHOP modulate macrophage apoptosis and the development of bleomycin-induced pulmonary fibrosis.
Grp78 Loss in Epithelial Progenitors Reveals an Age-linked Role for Endoplasmic Reticulum Stress in Pulmonary Fibrosis.
Heat Shock Protein 27 Plays a Pivotal Role in Myofibroblast Differentiation and in the Development of Bleomycin-Induced Pulmonary Fibrosis.
Heat shock protein 70 protects against bleomycin-induced pulmonary fibrosis in mice.
HSP90 Inhibition and Modulation of the Proteome: Therapeutical Implications for Idiopathic Pulmonary Fibrosis (IPF).
Hsp90 regulation of fibroblast activation in pulmonary fibrosis.
Intracellular Heat Shock Protein 70 Deficiency in Pulmonary Fibrosis.
Introduction of antisense oligonucleotides to heat shock protein 47 prevents pulmonary fibrosis in lipopolysaccharide-induced pneumopathy of the rat.
JAK1-dependent transphosphorylation of JAK2 limits the antifibrotic effects of selective JAK2 inhibitors on long-term treatment.
Pirfenidone attenuates expression of HSP47 in murine bleomycin-induced pulmonary fibrosis.
Post-treatment with a heat shock protein 90 inhibitor prevents chronic lung injury and pulmonary fibrosis, following acute exposure of mice to HCl.
Retraction notice to "Introduction of antisense oligonucleotides to Heat Shock Protein 47 prevents pulmonary fibrosis in lipopolysaccharide-induced pneumopathy of the rat" [Eur. J. Pharmacol. 564/1-3 (2007) 174-180].
Role of heat shock protein 60 (HSP60) on paraquat intoxication.
Simvastatin impairs the induction of pulmonary fibrosis caused by a western style diet: a preliminary study.
Suppression of expression of heat shock protein 70 by gefitinib and its contribution to pulmonary fibrosis.
The HSP90 Inhibitor, AUY-922, Ameliorates the Development of Nitrogen Mustard-Induced Pulmonary Fibrosis and Lung Dysfunction in Mice.
[Expression of heat shock protein 70 in lung and plasma of rats with pulmonary fibrosis induced by SiO2].
Purpura
A unique molecular chaperone Cosmc required for activity of the mammalian core 1 beta 3-galactosyltransferase.
Heat shock protein 70-2 and tumor necrosis factor-? gene polymorphisms in Chinese children with Henoch-Schönlein purpura.
Toll-like receptors 2 and 4 cell surface expression reflects endotoxin tolerance in Henoch-Schönlein purpura.
Purpura, Thrombocytopenic, Idiopathic
Expression of the 60 kDa and 71 kDa heat shock proteins and presence of antibodies against the 71 kDa heat shock protein in pediatric patients with immune thrombocytopenic purpura.
Significant reductions in apoptosis-related proteins (HSPA6, HSPA8, ITGB3, YWHAH, and PRDX6) are involved in immune thrombocytopenia.
[Relationship between the expressions of glucocorticoid receptors ?, ?, ?, p and heat shock protein 90 mRNA in patients with primary immune thrombocytopenia resistant to the glucocorticoid].
Q Fever
Efficient activation of T cells by human monocyte-derived dendritic cells (HMDCs) pulsed with Coxiella burnetii outer membrane protein Com1 but not by HspB-pulsed HMDCs.
Evaluation of the recombinant Heat shock protein B (HspB) of Coxiella burnetii as a potential antigen for immunodiagnostic of Q fever in goats.
In the Search of Potential Serodiagnostic Proteins to Discriminate Between Acute and Chronic Q Fever in Humans. Some Promising Outcomes.
[COMPARISON OF DIAGNOSTIC EFFECTIVENESS OF METHODS OF DETECTION OF COXIELLA BURNETII IN BLOOD OF PATIENTS WITH Q FEVER BASED ON AMPLIFI- CATION OF 16S rRNA GENE FRAGMENTS (STANDARD PCR) AND groEL GENE (REAL- TIME PCR)].
Rabies
Identification of heat shock protein 70 in the rabies virion.
Rabies viruses leader RNA interacts with host Hsc70 and inhibits virus replication.
Radiation Fibrosis Syndrome
Sodium tanshinone IIA sulfonate attenuates radiation-induced fibrosis damage in cardiac fibroblasts.
Radiculopathy
Preconditioning crush increases the survival rate of motor neurons after spinal root avulsion.
Raynaud Disease
Modulation of ?(2C) adrenergic receptor temperature-sensitive trafficking by HSP90.
Rectal Neoplasms
Deciphering the Inhibition Mechanism of under Trial Hsp90 Inhibitors and Their Analogues: A Comparative Molecular Dynamics Simulation.
GRP78 Protein Expression as Prognostic Values in Neoadjuvant Chemoradiotherapy and Laparoscopic Surgery for Locally Advanced Rectal Cancer.
Low molecular weight heat shock protein HSP27 is a prognostic indicator in rectal cancer but not colon cancer.
Relapsing Fever
Differentiation Borrelia Species in Environmental Samples with High-Resolution DNA Melting Analysis.
Molecular characterization of 'Candidatus Borrelia tachyglossi' (family Spirochaetaceae) in echidna ticks, Bothriocroton concolor.
Renal Insufficiency
Expression of 90-kDa heat shock protein within regenerative tubular cells in a patient with acute oliguric renal failure due to malignant hypertension.
Heat shock protein 60 is released in immune-mediated glomerulonephritis and aggravates disease: in vivo evidence for an immunologic danger signal.
Oxidative stress and cellular stress response in diabetic nephropathy.
Renal Insufficiency, Chronic
Association of polymorphisms of THBS2 and HSPA8 with hypertension in Japanese individuals with chronic kidney disease.
The heat shock protein profile in children with chronic kidney disease.
The Ratio of Osteoprotegerin to Fetuin-A Is Independently Associated with Vascular Stiffness in Hemodialysis Patients.
Reoviridae Infections
Targeting Heat Shock Protein 70 as an antiviral strategy against grass carp reovirus infection.
Reperfusion Injury
Anandamide enhances expression of heat shock protein 72 to protect against ischemia-reperfusion injury in rat heart.
Benefit of HSP90? intervention on ischemia-reperfusion injury of venous blood-congested flaps.
Calpain-mediated Hsp70.1 cleavage in hippocampal CA1 neuronal death.
Clearance of damaged mitochondria via mitophagy is important to the protective effect of ischemic preconditioning in kidneys.
Differential expression of heat shock proteins 70-1 and 70-2 mRNA after ischemia-reperfusion injury of rat kidney.
Down-regulation of GRP78 enhances apoptosis via CHOP pathway in retinal ischemia-reperfusion injury.
During ischemia-reperfusion in rat kidneys, heat shock response is not regulated by expressional changes of heat shock factor 1.
Ecto-5'-nucleotidase plays a role in the cardioprotective effects of heat shock protein 72 in ischemia-reperfusion injury in rat hearts.
Effects of acupuncture at Baihui (DU20) and Zusanli (ST36) on the expression of heat shock protein 70 and tumor necrosis factor ? in the peripheral serum of cerebral ischemia-reperfusion-injured rats.
Effects of geranyl-geranyl-acetone administration before heat shock preconditioning for conferring tolerance against ischemia-reperfusion injury in rat livers.
Ergothioneine modulates proinflammatory cytokines and heat shock protein 70 in mesenteric ischemia and reperfusion injury.
Ergothioneine pretreatment protects the liver from ischemia-reperfusion injury caused by increasing hepatic heat shock protein 70.
Evaluation of warm ischemia-reperfusion injury using heat shock protein in the rat liver.
Gene therapy for myocardial protection: transfection of donor hearts with heat shock protein 70 gene protects cardiac function against ischemia-reperfusion injury.
Gene transfer of heat shock protein 70 protects lung grafts from ischemia-reperfusion injury.
Geranylgeranylacetone attenuates cerebral ischemia-reperfusion injury in rats through the augmentation of HSP 27 phosphorylation: a preliminary study.
Geranylgeranylacetone protects against cerebral ischemia and reperfusion injury: HSP90 and eNOS phosphorylation involved.
Heat shock protein 70 gene transfection protects mitochondrial and ventricular function against ischemia-reperfusion injury.
Heat shock protein 70 gene transfection protects rat myocardium cell against anoxia-reoxygeneration injury.
Heat shock protein 70 induced by heat stress protects heterotopically transplanted hearts in rats.
Heat shock protein 70 or heat shock protein 27 overexpressed in human endothelial cells during posthypoxic reoxygenation can protect from delayed apoptosis.
Heat shock protein 70: A promising therapeutic target for myocardial ischemia-reperfusion injury.
Heat shock protein 72 enhances manganese superoxide dismutase activity during myocardial ischemia-reperfusion injury, associated with mitochondrial protection and apoptosis reduction.
Heat shock protein 90 inhibition abrogates TLR4-mediated NF-?B activity and reduces renal ischemia-reperfusion injury.
Heat shock protein 90-binding agents protect renal cells from oxidative stress and reduce kidney ischemia-reperfusion injury.
Heat shock protein expression is highly sensitive to ischemia-reperfusion injury in rat kidneys.
Human heat shock protein 27 exacerbates ischemia reperfusion injury in rats by reducing the number of T regulatory cells.
Human heat shock protein 27 overexpressing mice are protected against hepatic ischemia and reperfusion injury.
Hydrogen-rich saline protects against small-scale liver ischemia-reperfusion injury by inhibiting endoplasmic reticulum stress.
Hypoxia and fetal heart development.
In vivo gene transfection with heat shock protein 70 enhances myocardial tolerance to ischemia-reperfusion injury in rat.
Induction of heat shock protein 70 and preconditioning by sevoflurane: a potent protective interaction against myocardial ischemia-reperfusion injury.
Induction of heme oxygenase-1 in kidneys during ex vivo warm perfusion.
Inhibition of heat shock protein family A member 8 attenuates spinal cord ischemia-reperfusion injury via astrocyte NF-?B/NLRP3 inflammasome pathway : HSPA8 inhibition protects spinal ischemia-reperfusion injury.
Insulin-induced myocardial protection in isolated ischemic rat hearts requires p38 MAPK phosphorylation of Hsp27.
Intracellular and extracellular expression of the major inducible 70kDa heat shock protein in experimental ischemia-reperfusion injury of the spinal cord.
Ischemic preconditioning of the liver in rats: implications of heat shock protein induction to increase tolerance of ischemia-reperfusion injury.
Lipopolysaccharide pretreatment attenuates myocardial infarct size: A possible mechanism involving heat shock protein 70-inhibitory kappaBalpha complex and attenuation of nuclear factor kappaB.
Mice that overexpress human heat shock protein 27 have increased renal injury following ischemia reperfusion.
Mitochondrial import of PKCepsilon is mediated by HSP90: a role in cardioprotection from ischaemia and reperfusion injury.
Modulation of Poly(ADP-Ribose) Polymerase-1 (PARP-1)-Mediated Oxidative Cell Injury by Ring Finger Protein 146 (RNF146) in Cardiac Myocytes.
Myocardial protection using an omega-3 fatty acid infusion: quantification and mechanism of action.
Oral administration of Lactobacillus induces cardioprotection.
Overexpressed heat shock protein 70 attenuates hypoxic injury in coronary endothelial cells.
Oxymatrine on Hsp90a expression and apoptosis in a model of lung ischemia-reperfusion injury.
Preconditioned somatothermal stimulation on median nerve territory increases myocardial heat shock protein 70 and protects rat hearts against ischemia-reperfusion injury.
Preconditioning somatothermal stimulation on right seventh intercostal nerve territory increases hepatic heat shock protein 70 and protects the liver from ischemia-reperfusion injury in rats.
Prior heat stress improves survival of ischemic-reperfused skeletal muscle in vivo.
Protective effect of heat preconditioning of rat liver graft resulting in improved transplant survival.
Protective role of microRNA-27a upregulation and HSP90 silencing against cerebral ischemia-reperfusion injury in rats by activating PI3K/AKT/mTOR signaling pathway.
Reduction of skeletal muscle injury in composite tissue allotransplantation by heat stress preconditioning.
Retraction notice to "Protective role of microRNA-27a upregulation and HSP90 silencing against cerebral ischemia-reperfusion injury in rats by activating PI3K/AKT/mTOR signaling pathway" [Int. Immunopharmacol. 86 (2020) 106635].
Role of heat shock protein 70 in hepatic ischemia-reperfusion injury in mice.
Role of ultrasound and microbubble-mediated heat shock protein 72 siRNA on ischemia-reperfusion liver injury in rat.
Roles of MAPKAPK-2 and HSP27 in the reduction of renal ischemia-reperfusion injury by ischemic postconditioning in rats.
Salvianolate increases heat shock protein expression in a cerebral ischemia-reperfusion injury model.
Selective renal overexpression of human heat shock protein 27 reduces renal ischemia-reperfusion injury in mice.
Sequence of reperfusion influences ischemia/reperfusion injury and primary graft function following porcine liver transplantation.
Sevoflurane relieves hepatic ischemia-reperfusion injury by inhibiting the expression of Grp78.
Sex differences in heat shock protein 72 expression and localization in rats following renal ischemia-reperfusion injury.
The augmentative effect of repeated heat shock preconditioning on the production of heat shock protein 72 and on ischemic tolerance in rat liver tissue.
The mechanistic studies of acupuncture and moxibustion in Taiwan.
The protective effects of heat shock protein 22 in lung ischemia-reperfusion injury mice.
The role of heat shock protein 90 in modulating ischemia-reperfusion injury in the kidney.
The role of microRNA in modulating myocardial ischemia-reperfusion injury.
Time course of tolerance to ischemia-reperfusion injury and induction of heat shock protein 72 by heat stress in the rat heart.
Vitamin D3 and erythropoietin protect against renal ischemia-reperfusion injury via heat shock protein 70 and microRNA-21 expression.
[Effects of Electroacupuncture and Moxibustion Pretreatment on Expressions of HSP 27, HSP 70, HSP 90 at Different Time-points in Rabbits with Myocardial Ischemia-reperfusion Injury].
[In vivo gene transfection with heat shock protein 70 enhances myocardial tolerance to ischemia-reperfusion injury in rat]
[Mild hypothermia combined with hydrogen sulfide alleviates hippocampal endoplasmic reticulum stress after global cerebral ischemia-reperfusion].
[Progress of researches on the protective effect of acupucture in resisting myocardial ischemia-reperfusion injury]
[Protective effect of heat shock protein 70 and magnesium sulfate supplementation on renal ischemia reperfusion injury].
[Role of endoplasmic reticulum stress-related molecule GRP78 in global cerebral ischemia-reperfusion injury aggravated by hypertension in rats].
[The protective effect of heat shock protein 72 by Doxorubicin in cold ischemia-reperfusion injury of the rat liver]
Reproductive Tract Infections
Humoral immune response to conserved epitopes of Chlamydia trachomatis and human 60-kDa heat-shock protein in women with pelvic inflammatory disease.
Immune Recognition of the 60kD Heat Shock Protein: Implications for Subsequent Fertility.
Immunity to heat shock proteins and pregnancy outcome.
Respiratory Distress Syndrome
A cytosolic heat shock protein 90 and co-chaperone p23 complex activates RIPK3/MLKL during necroptosis of endothelial cells in acute respiratory distress syndrome.
Alveolar macrophages of patients with adult respiratory distress syndrome express high levels of heat shock protein 72 mRNA.
Covid-19, heat shock proteins, and autoimmune bullous diseases: a potential link deserving further attention.
Enhanced expression of 70-kilodalton heat shock protein limits cell division in a sepsis-induced model of acute respiratory distress syndrome.
Enhanced heat shock protein 70 expression alters proteasomal degradation of IkappaB kinase in experimental acute respiratory distress syndrome.
Heat shock protein 70 and the acute respiratory distress syndrome.
Inducibility of the 70 kD heat shock protein in peripheral blood monocytes is decreased in human acute respiratory distress syndrome and recovers over time.
Molecular-biological analysis of acute lung injury (ALI) induced by heat exposure and/or intravenous administration of oleic acid.
Retinal Degeneration
A role of Heat Shock Protein 70 in Photoreceptor Cell Death: Potential as a Novel Therapeutic Target in Retinal Degeneration.
Activation of the molecular chaperone, sigma 1 receptor, preserves cone function in a murine model of inherited retinal degeneration.
Clinical and functional analyses of AIPL1 variants reveal mechanisms of pathogenicity linked to different forms of retinal degeneration.
Correction to: Human embryonic stem cell-derived extracellular vesicles alleviate retinal degeneration by upregulating Oct4 to promote retinal Müller cell retrodifferentiation via HSP90.
Effect of the absence of heat shock protein 70.1 (hsp70.1) on retinal photoreceptors in normal and rd mice.
Expression of the Endoplasmic Reticulum Stress Marker GRP78 in the Normal Retina and Retinal Degeneration Induced by Blue LED Stimuli in Mice.
Hsp90 as a Potential Therapeutic Target in Retinal Disease.
Hsp90 inhibition protects against inherited retinal degeneration.
Human embryonic stem cell-derived extracellular vesicles alleviate retinal degeneration by upregulating Oct4 to promote retinal Müller cell retrodifferentiation via HSP90.
Protective effect of sulforaphane against retinal degeneration in the Pde6(rd10) mouse model of retinitis pigmentosa.
Quantitative proteomics of a presymptomatic A53T alpha-synuclein Drosophila model of Parkinson disease.
Small heat shock protein ?A-crystallin prevents photoreceptor degeneration in experimental autoimmune uveitis.
Suppression of HSP27 Restores Retinal Function and Protects Photoreceptors From Apoptosis in a Light-Induced Retinal Degeneration Animal Model.
Suppression of Light-Induced Retinal Degeneration by Quercetin via the AP-1 Pathway in Rats.
The effect of oxygen on retinal degeneration in wild-type and hsp70.1 knockout neonatal retinal degeneration mice.
The Molecular Chaperone GRP78/BiP as a Therapeutic Target for Neurodegenerative Disorders: A Mini Review.
The molecular chaperone Hsp90? deficiency causes retinal degeneration by disrupting Golgi organization and vesicle transportation in photoreceptors.
Unfolded protein response in a Drosophila model for retinal degeneration.
Retinal Detachment
Expression of two endoplasmic reticulum stress markers, GRP78 and GADD153, in rat retinal detachment model and its implication.
Heat shock protein 70 (HSP70) is critical for the photoreceptor stress response after retinal detachment via modulating anti-apoptotic Akt kinase.
Significant upregulation of small heat shock protein ?A-crystallin in retinal detachment.
Retinal Diseases
Heat shock cognate-70 gene expression declines during normal aging of the primate retina.
Hsp90 as a Potential Therapeutic Target in Retinal Disease.
Retinal Neovascularization
Development and Validation of Analytical Method for SH-1242 in the Rat and Mouse Plasma by Liquid Chromatography/Tandem Mass Spectrometry.
Hypoxia-mediated retinal neovascularization and vascular leakage in diabetic retina is suppressed by HIF-1? destabilization by SH-1242 and SH-1280, novel hsp90 inhibitors.
Retinal Perforations
Elevated Activating Transcription Factor 4 and Glucose-Regulated 78 Kda Protein Levels Correlate with Inflammatory Cytokines in the Aqueous Humor and Vitreous of Proliferative Diabetic Retinopathy.
Retinitis
[A potential of novel therapeutic approach by heat shock protein 70 expression in retinitis pigmentosa].
Retinitis Pigmentosa
AAV delivery of GRP78/BiP promotes adaptation of human RPE cell to ER stress.
Autophagy in Xenopus laevis rod photoreceptors is independently regulated by phototransduction and misfolded RHOP23H.
Hsp90 as a Potential Therapeutic Target in Retinal Disease.
Hsp90 inhibition protects against inherited retinal degeneration.
Prevention of autosomal dominant retinitis pigmentosa by systemic drug therapy targeting heat shock protein 90 (Hsp90).
Unfolded protein response in a Drosophila model for retinal degeneration.
[Role of Heat Shock Protein 70 in Retinitis Pigmentosa and a Novel Strategy for Treatment].
Retinoblastoma
70-kDa heat shock cognate protein interacts directly with the N-terminal region of the retinoblastoma gene product pRb. Identification of a novel region of pRb-mediating protein interaction.
A new member of the hsp90 family of molecular chaperones interacts with the retinoblastoma protein during mitosis and after heat shock.
Akt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 function.
Analysis of peripheral blood mononuclear cells gene expression in endurance horses by cDNA-AFLP technique.
Behçet's disease and antibody titers to various heat-shock protein 60s.
Deficient induction of human hsp70 heat shock gene transcription in Y79 retinoblastoma cells despite activation of heat shock factor 1.
Depsipeptide (FK228) preferentially induces apoptosis in BCR/ABL-expressing cell lines and cells from patients with chronic myelogenous leukemia in blast crisis.
Effect of 8-bromo-cyclic AMP on neuron specific enolase, heat shock protein, nitric oxide, nitric oxide synthase and nitric oxide synthase mRNA in human retinoblastoma HXO-Rb44 cells and cell differentiation.
Enhanced expression of 70-kilodalton heat shock protein limits cell division in a sepsis-induced model of acute respiratory distress syndrome.
Expression of heat shock protein 27 and alpha-crystallins in human retinoblastoma after chemoreduction.
Expression of heat shock protein 27 and proliferating cell nuclear antigen in human retinoblastoma.
Heat shock protein 27 promotes cell cycle progression by down-regulating E2F transcription factor 4 and retinoblastoma family protein p130.
Human T cell leukemia virus type 1 Tax associates with a molecular chaperone complex containing hTid-1 and Hsp70.
Identification of novel lipid droplet factors that regulate lipophagy and cholesterol efflux in macrophage foam cells.
Inhibition of Hsp90 function by ansamycins causes retinoblastoma gene product-dependent G1 arrest.
JC virus T'135, T'136 and T'165 proteins interact with cellular p107 and p130 in vivo and influence viral transformation potential.
Liver dual arterial blood supply maintains liver regeneration: Analysis of signaling pathways in rats.
Nuclear export of proteins and drug resistance in cancer.
Protein interaction of retinoblastoma gene product pRb110 with M(r) 73,000 heat shock cognate protein.
Reverse phase protein array profiling reveals distinct proteomic signatures associated with chronic myeloid leukemia progression and with chronic phase in the CD34-positive compartment.
Sulfoxythiocarbamate S-4 inhibits HSP90 in human cutaneous squamous cell carcinoma cells.
Targeted therapy of gastroenteropancreatic neuroendocrine tumours: preclinical strategies and future targets.
The Epstein-Barr virus nuclear antigen leader protein associates with hsp72/hsc73.
The J domain of simian virus 40 large T antigen is required to functionally inactivate RB family proteins.
The role of ferroptosis in digestive system cancer.
Tumor necrosis factor receptor-associated protein 1(TRAP1) regulates genes involved in cell cycle and metastases.
Rhabdomyosarcoma
Combined chemical-genetic approach identifies cytosolic HSP70 dependence in rhabdomyosarcoma.
Effect of inhibition of the Ubiquitin-Proteasome System and Hsp90 on growth and survival of Rhabdomyosarcoma cells in vitro.
Elevated levels of ribosomal proteins eL36 and eL42 control expression of Hsp90 in rhabdomyosarcoma.
Heat Shock protein 90: Role in Enterovirus 71 Entry and Assembly and Potential Target for Therapy.
High anti tumor activity against rhabdomyosarcoma cells and low normal cells cytotoxicity of heat shock protein 90 inhibitors, with special emphasis on 17-[2-(pyrrolidin-1-yl)ethyl]-aminno-17-demethoxygeldanamycin.
HSP90 antagonist, geldanamycin, inhibits proliferation, induces apoptosis and blocks migration of rhabdomyosarcoma cells in vitro and seeding into bone marrow in vivo.
Non-Thermal Plasma Application in Tumor-Bearing Mice Induces Increase of Serum HMGB1.
Rhabdomyosarcoma, Alveolar
17-DMAG dually inhibits Hsp90 and histone lysine demethylases in alveolar rhabdomyosarcoma.
Rheumatic Diseases
Detection of autoantibodies to the 90 kDa heat shock protein in systemic lupus erythematosus and other autoimmune diseases.
In the Search of Potential Serodiagnostic Proteins to Discriminate Between Acute and Chronic Q Fever in Humans. Some Promising Outcomes.
Levels of antibodies against human heat shock protein (HSP) 60 in patients with glaucoma in Poland.
Rheumatic Fever
Expression of heat-shock proteins in Streptococcus pyogenes and their immunoreactivity with sera from patients with streptococcal diseases.
Rheumatic Heart Disease
Decreased Cardiac Expression of Heat Shock Protein 27 is Associated with Atrial Fibrillation in Patients with Rheumatic Heart Disease.
Rhinitis
miR?495 enhances the efficacy of radiotherapy by targeting GRP78 to regulate EMT in nasopharyngeal carcinoma cells.
Rhinitis, Allergic
Correlations Between the Adenotonsillar Microbiome and Clinical Characteristics of Pediatric Patients With Snoring.
Disruption of Heat Shock Protein 90 (Hsp90)-Protein Kinase C? (PKC?) Interaction by (-)-Maackiain Suppresses Histamine H1 Receptor Gene Transcription in HeLa Cells.
Expression of HSP70 in peripheral lymphocytes of the patients with allergic rhinitis.
Expression of substance P, vasoactive intestinal peptide and heat shock protein 70 in nasal mucosal smears of patients with allergic rhinitis: investigation using a liquid-based method.
T-helper 2 cytokine-induced heat shock protein 70 secretion and its potential association with allergic rhinitis.
Rhinitis, Allergic, Seasonal
Expression of substance P, vasoactive intestinal peptide and heat shock protein 70 in nasal mucosal smears of patients with allergic rhinitis: investigation using a liquid-based method.
Rift Valley Fever
Multi-faceted proteomic characterization of host protein complement of Rift Valley fever virus virions and identification of specific heat shock proteins, including HSP90, as important viral host factors.
Rosacea
Hypothesis of demodicidosis rosacea flushing etiopathogenesis.
Rotavirus Infections
Amino acid domains 280-297 of VP6 and 531-554 of VP4 are implicated in heat shock cognate protein hsc70-mediated rotavirus infection.
Rotavirus receptor proteins Hsc70 and integrin ?v?3 are located in the lipid microdomains of animal intestinal cells.
The molecular chaperone heat shock protein-90 positively regulates rotavirus infectionx.
The tight junction protein JAM-A functions as coreceptor for rotavirus entry into MA104 cells.
Rubella
Heat Shock Protein 90 Ensures the Integrity of Rubella virus p150 Protein and Supports Viral Replication.
Salmonella Infections
Co-expression of S. Typhi GroEL and IL-22 gene augments immune responses against Salmonella infection.
Hsc70 is a Component of Bacterially Generated Actin-Rich Structures: An Immunolocalization Study.
Salpingitis
Cell-mediated immune response to the recombinant 57-kDa heat-shock protein of Chlamydia trachomatis in women with salpingitis.
Humoral immune response to the chlamydial heat shock proteins hsp60 and hsp70 in Chlamydia-associated chronic salpingitis with tubal occlusion.
Serological responses of patients with ectopic pregnancy to epitopes of the Chlamydia trachomatis 60 kDa heat shock protein.
Sarcoidosis
A quantitative proteomic analysis of soluble bronchoalveolar fluid proteins from patients with sarcoidosis and chronic beryllium disease.
Association between heat shock protein 70/Hom genetic polymorphisms and uveitis in patients with sarcoidosis.
Genetic influences on sarcoidosis.
[Detection and identification of mycobacterial gene in skin lesions and lymph nodes in patients with sarcoidosis]
Sarcoma
17-AAG mediated targeting of Hsp90 limits tert activity in peritoneal sarcoma related malignant ascites by downregulating cyclin D1 during cell cycle entry.
A phase 1 study of the heat shock protein 90 inhibitor retaspimycin hydrochloride (IPI-504) in patients with gastrointestinal stromal tumors or soft tissue sarcomas.
CD3- large granular lymphocytes recognize a heat-inducible immunogenic determinant associated with the 72-kD heat shock protein on human sarcoma cells.
Combination therapy with HSP90 inhibitor 17-DMAG reconditions the tumor microenvironment to improve recruitment of therapeutic T cells.
Comparison of tumor-specific immunogenicities of stress-induced proteins gp96, hsp90, and hsp70.
Conjunctival Melanoma: Genetic and Epigenetic Insights of a Distinct Type of Melanoma.
Distinct profiles of oxidative stress-related and matrix proteins in adult bone and soft tissue osteosarcoma and desmoid tumors: A proteomics study.
Elevated expression of HSP90 and the antitumor effect of an HSP90 inhibitor via inactivation of the Akt/mTOR pathway in undifferentiated pleomorphic sarcoma.
Engineered protein disaggregases mitigate toxicity of aberrant prion-like fusion proteins underlying sarcoma.
Expression and its clinical significance of heat shock protein gp96 in human osteosarcoma.
Expression of gene-specific RNA in cultured cells exposed to rotating 60-Hz magnetic fields.
Expression of HSP90 in gastrointestinal stromal tumours and mesenchymal tumours.
Heat shock protein 70-associated peptides elicit specific cancer immunity.
Heat shock protein 90 inhibitors in non-small-cell lung cancer.
Heat shock protein antibodies in sarcoma patients undergoing 41.8 degrees C whole body hyperthermia.
HSP90 inhibition as a means of radiosensitizing resistant, aggressive soft tissue sarcomas.
Identification of novel lipid droplet factors that regulate lipophagy and cholesterol efflux in macrophage foam cells.
Immunization with heat shock protein 70 from methylcholanthrene-induced sarcomas induces tumor protection correlating with in vitro T cell responses.
Liver dual arterial blood supply maintains liver regeneration: Analysis of signaling pathways in rats.
Predicting drug susceptibility of non-small cell lung cancers based on genetic lesions.
Prophylactic Antitumor Effect of Mixed Heat Shock Proteins/Peptides in Mouse Sarcoma.
Protein kinase C delta-mediated cytoskeleton remodeling is involved in aloe-emodin-induced photokilling of human lung cancer cells.
STA-8666, a novel HSP90 inhibitor/SN-38 drug conjugate, causes complete tumor regression in preclinical mouse models of pediatric sarcoma.
Structural and mechanistic insights into Hsp104 function revealed by synchrotron X-ray footprinting.
Targeted agents for sarcoma: is individualized therapy possible in such a diverse tumor type?
Targets for cancer therapy in childhood sarcomas.
Sarcoma, Avian
A 50-kDa cytosolic protein complexed with the 90-kDa heat shock protein (hsp90) is the same protein complexed with pp60v-src hsp90 in cells transformed by the Rous sarcoma virus.
Biosynthesis of a novel transformation-sensitive heat-shock protein that binds to collagen. Regulation by mRNA levels and in vitro synthesis of a functional precursor.
Evaluation of viral and mammalian promoters for driving transgene expression in mouse liver.
Reconstitution of the multiprotein complex of pp60src, hsp90, and p50 in a cell-free system.
Sarcoma, Ewing
A pivotal role for heat shock protein 90 in Ewing sarcoma resistance to anti-insulin-like growth factor 1 receptor treatment: in vitro and in vivo study.
Cooperative treatment effectiveness of ATR and HSP90 inhibition in Ewing's sarcoma cells.
Heat shock protein 72 (HSP72), a hyperthermia-inducible immunogenic determinant on leukemic K562 and Ewing's sarcoma cells.
Pre-clinical efficacy of PU-H71, a novel HSP90 inhibitor, alone and in combination with bortezomib in Ewing sarcoma.
Proteomic identification of heat shock protein 27 as a differentiation and prognostic marker in neuroblastoma but not in Ewing's sarcoma.
Sarcoma, Kaposi
Hsp90 inhibitors are efficacious against Kaposi Sarcoma by enhancing the degradation of the essential viral gene LANA, of the viral co-receptor EphA2 as well as other client proteins.
Sarcoma, Synovial
Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin prevents synovial sarcoma proliferation via apoptosis in in vitro models.
Synergism of heat shock protein 90 and histone deacetylase inhibitors in synovial sarcoma.
Sarcopenia
Plasma heat shock protein 72 as a biomarker of sarcopenia in elderly people.
Sixteen weeks of resistance training decrease plasma heat shock protein 72 (eHSP72) and increase muscle mass without affecting high sensitivity inflammatory markers' levels in sarcopenic men.
Schistosomiasis
Elevated serum antibody against Schistosoma japonicum HSP60 as a promising biomarker for liver pathology in schistosomiasis.
Expression of heat shock protein 47, transforming growth factor-beta 1, and connective tissue growth factor in liver tissue of patients with Schistosoma japonicum-induced hepatic fibrosis.
Fine specificity of autoantibodies to calreticulin: epitope mapping and characterization.
Schistosomiasis japonica
Identification of the resistance of a novel molecule heat shock protein 90alpha (HSP90alpha) in Microtus fortis to Schistosoma japonicum infection.
[Roles of transforming growth factor - ?1 and heat shock protein 47 in progression of Schistosoma japonicum-induced hepatic fibrosis].
Schistosomiasis mansoni
The humoral response to heat shock protein 70 in human and murine Schistosomiasis mansoni.
Scleroderma, Systemic
Antibodies to mycobacterial 65 kDa heat shock protein in systemic sclerosis (scleroderma).
Autoantibodies to a collagen-specific molecular chaperone, heat-shock protein 47, in systemic sclerosis.
Heat shock protein 90 inhibition: A potential double- or triple-edged sword in the treatment of mucous membrane pemphigoid.
Inhibition of Hsp90 Counteracts the Established Experimental Dermal Fibrosis Induced by Bleomycin.
Plasma Hsp90 levels in patients with systemic sclerosis and relation to lung and skin involvement: a cross-sectional and longitudinal study.
Serum heat shock protein 27 levels in patients with systemic sclerosis: a possible biomarker of skin sclerosis.
Serum levels of heat shock protein 70, a biomarker of cellular stress, are elevated in patients with systemic sclerosis: association with fibrosis and vascular damage.
Scrapie
Changes in HSP gene and protein expression in natural scrapie with brain damage.
Differential molecular chaperone response associated with various mouse adapted scrapie strains.
Increased expression of heat shock protein, transferrin, and beta 2-microglobulin in astrocytes during scrapie.
Infection by ME7 prion is not modified in transgenic mice expressing the yeast chaperone Hsp104 in neurons.
Overexpression of PLK3 Mediates the Degradation of Abnormal Prion Proteins Dependent on Chaperone-Mediated Autophagy.
Polymorphisms in the HSP90AA1 5' flanking region are associated with scrapie incubation period in sheep.
Scrub Typhus
A highly sensitive quantitative real-time PCR assay based on the groEL gene of contemporary Thai strains of Orientia tsutsugamushi.
Laboratory diagnosis and genotype identification of scrub typhus from Pinggu district, Beijing, 2008 and 2010.
Molecular epidemic survey on co-prevalence of scrub typhus and marine typhus in Yuxi city, Yunnan province of China.
Molecular phylogenetic analysis of Orientia tsutsugamushi based on the groES and groEL genes.
Scrub typhus in Puducherry, India: Application of nested PCR targeting three different genes - 56 kDa, 47 kDa and groEL of Orientia tsutsugamushi and comparison with ST IgM ELISA.
Single-nucleotide polymorphisms in Toll-like receptor (TLR)-2, TLR4 and heat shock protein 70 genes and susceptibility to scrub typhus.
Use of Multiplex Real-Time PCR to Diagnose Scrub Typhus.
Seizures
Behavioral changes and expression of heat shock protein hsp-70 mRNA, brain-derived neurotrophic factor mRNA, and cyclooxygenase-2 mRNA in rat brain following seizures induced by systemic administration of kainic acid.
Bilateral intranigral NMDA blockade increases status duration and neuronal injury from systemic kainic acid.
Cerebral neurons of transgenic ALS mice are vulnerable to glutamate release stimulation but not to increased extracellular glutamate due to transport blockade.
Cognitive Function and Heat Shock Protein 70 in Children With Temporal Lobe Epilepsy.
Correlation between electroconvulsive seizure and HSC70 mRNA induction in mice brain.
Correlation between seizure intensity and stress protein expression after limbic epilepsy in the rat brain.
Decrease in level of APG-2, a member of the heat shock protein 110 family, in murine brain following systemic administration of kainic acid.
Deep prepiriform cortex modulates kainate-induced hippocampal injury.
Effects of exogenous heat shock protein 70 and quercetin on NMDA-induced seizures.
Effects of ferulic acid on oxidative stress, heat shock protein 70, connexin 43, and monoamines in the hippocampus of pentylenetetrazole-kindled rats.
Effects of manganese complexes of curcumin and diacetylcurcumin on kainic acid-induced neurotoxic responses in the rat hippocampus.
Effects of PRI-2191--a low-calcemic analog of 1,25-dihydroxyvitamin D3 on the seizure-induced changes in brain gene expression and immune system activity in the rat.
Epilepsy: HSP90 inhibition suppresses seizures.
Exogenous protein Hsp70/Hsc70 can penetrate into brain structures and attenuate the severity of chemically-induced seizures.
Gene therapy with HSP72 is neuroprotective in rat models of stroke and epilepsy.
Gradation of kainic acid-induced rat limbic seizures and expression of hippocampal heat shock protein-70.
Heat shock protein 27 rescues motor neurons following nerve injury and preserves muscle function.
High induction threshold for transcription factor KROX-20 in the rat brain: partial co-expression with heat shock protein 70 following limbic seizures.
Hippocampal expression of heat shock proteins in mesial temporal lobe epilepsy with psychiatric comorbidities and their relation to seizure outcome.
Hsp60 response in experimental and human temporal lobe epilepsy.
Hyperthermic induction of the 27-kDa heat shock protein (Hsp27) in neuroglia and neurons of the rat central nervous system.
Increased expression of mRNA encoding calbindin-D28K, the glucose-regulated proteins, or the 72 kDa heat-shock protein in three models of acute CNS injury.
Induction by synaptic zinc of heat shock protein-70 in hippocampus after kainate seizures.
Induction of constitutive heat shock protein 73 mRNA in the dentate gyrus by seizures.
Induction of glucose regulated protein (grp78) and inducible heat shock protein (hsp70) mRNAs in rat brain after kainic acid seizures and focal ischemia.
Induction of the stress response after inflicted and non-inflicted traumatic brain injury in infants and children.
MR imaging and 1H-MR spectroscopy in a case of juvenile Alexander disease.
Neurofilament heavy chain and heat shock protein 70 as markers of seizure-related brain injury.
Overexpression of 14-3-3? Increases Brain Levels of C/EBP Homologous Protein CHOP.
Overexpression of rat heat shock protein 70 reduces neuronal injury after transient focal ischemia, transient global ischemia, or kainic acid-induced seizures.
Protective effect of vineatrol against kainic acid induced seizures, oxidative stress and on the expression of heat shock proteins in rats.
Responses of heat shock proteins hsp27, alphaB-crystallin, and hsp70 in rat brain after kainic acid-induced seizure activity.
Silymarin Inhibits Glutamate Release and Prevents against Kainic Acid-Induced Excitotoxic Injury in Rats.
Strain-dependent effects of sub-chronically infused losartan against kainic acid-induced seizures, oxidative stress, and heat shock protein 72 expression.
The neuroprotective effects of heat shock protein 27 overexpression in transgenic animals against kainate-induced seizures and hippocampal cell death.
The pattern of neuronal injury following seizures induced by intranigral kainic acid.
Truncating biallelic variant in DNAJA1, encoding the co-chaperone Hsp40, is associated with intellectual disability and seizures.
[EFfect of quercetin on the severity of chemically induced seizures and the content of heat shock protein 70 in the rat brain structures]
[Effects of W-7 on the expression of GRP78 and neuronal apoptosis in immature rat hippocampus after status convulsion].
[The microglial activation and the expression of heat shock protein 27 through the propagation pathway of kainic acid-induced hippocampal seizure in the rat]
Seizures, Febrile
Expression of Hsp72 in lymphocytes in patients with febrile convulsion.
Sepsis
A Case of Bloodstream Infection of Bacteroides pyogenes Identified by 16S rRNA, gyrB, and hsp60 Gene Sequencing.
An in vitro model to consider the effect of 2 mM glutamine and KNK437 on endotoxin-stimulated release of heat shock protein 70 and inflammatory mediators.
Analysis of two human leukocyte antigen-linked polymorphic heat shock protein 70 genes in patients with severe sepsis.
Association between heat shock protein 70 gene polymorphisms and clinical outcomes in intensive care unit patients with sepsis.
Attenuation of mitochondrial unfolded protein response is associated with hepatic dysfunction in septic rats.
Caffeic acid phenethyl ester reduces mortality and sepsis-induced lung injury in rats*
Caffeic acid phenethyl ester reduces mortality and sepsis-induced lung injury in rats.
Cd40 but not CD154 knockout mice have reduced inflammatory response in polymicrobial sepsis: a potential role for Escherichia coli heat shock protein 70 in CD40-mediated inflammation in vivo.
Chronic acid water feeding protects mice against lethal gut-derived sepsis due to Pseudomonas aeruginosa.
Core temperature correlates with expression of selected stress and immunomodulatory genes in febrile patients with sepsis and noninfectious SIRS.
Curcumin suppresses inflammatory cytokines and heat shock protein 70 release and improves metabolic parameters during experimental sepsis.
Cytochrome c oxidase as the target of the heat shock protective effect in septic liver.
Damage-associated molecular patterns and immune activation in bipolar disorder.
Dehydroepiandrosterone: a modulator of cellular immunity and heat shock protein 70 production during polymicrobial sepsis.
Differential induction of brain heme oxygenase-1 and heat shock protein 70 mRNA in sepsis.
Early propranolol treatment induces lung heme-oxygenase-1, attenuates metabolic dysfunction, and improves survival following experimental sepsis.
Endotoxin inhibits heat shock protein 70 (HSP70) expression in peripheral blood mononuclear cells of patients with severe sepsis.
Enhanced expression of heat shock proteins in activated polymorphonuclear leukocytes in patients with sepsis.
Exogenous heat shock cognate protein 70 pretreatment attenuates cardiac and hepatic dysfunction with associated anti-inflammatory responses in experimental septic shock.
Exogenous heat shock protein 70 mediates sepsis manifestations and decreases the mortality rate in rats.
Expression of heat shock protein 70 in leukocytes of patients with sepsis.
Extracellular heat shock protein 60 (Hsp60) levels in children with septic shock.
Genetic polymorphisms in sepsis and septic shock: role in prognosis and potential for therapy.
Glutamine attenuates lung injury and improves survival after sepsis: role of enhanced heat shock protein expression.
Glutamine reduces myocardial cell apoptosis in a rat model of sepsis by promoting expression of heat shock protein 90.
Glutamine suppresses Hsp72 not Hsp90? and is not inducing Th1, Th2, or Th17 cytokine responses in human septic PBMCs.
Glutamine's protection against sepsis and lung injury is dependent on heat shock protein 70 expression.
GYY4137 attenuates LPS-induced acute lung injury via heme oxygenase-1 modulation.
Heat shock pretreatment prevents cardiac mitochondrial dysfunction during sepsis.
Heat shock protein 60 as a biomarker for acute kidney injury secondary to septic shock in pediatric patients, Egyptian multicenter experience.
Heat shock protein 72 expressing stress in sepsis: unbridgeable gap between animal and human studies--a hypothetical "comparative" study.
Heat shock protein 90 inhibitors prolong survival, attenuate inflammation, and reduce lung injury in murine sepsis.
Heat shock response reduces intestinal permeability in septic mice: potential role of interleukin-10.
Heat-shock protein-90 prolongs septic neutrophil survival by protecting c-Src kinase and caspase-8 from proteasomal degradation.
HSP-Target of Therapeutic Agents in Sepsis Treatment.
Identification of meningococcal LPS as a major monocyte activator in IL-10 depleted shock plasmas and CSF by blocking the CD14-TLR4 receptor complex.
Impaired inducibility of heat shock protein 70 in peripheral blood lymphocytes of patients with severe sepsis.
Increased extracellular heat shock protein 90? in severe sepsis and SIRS associated with multiple organ failure and related to acute inflammatory-metabolic stress response in children.
Increased grp78 transcription is correlated to reduced tlr4 transcription in patients surviving sepsis.
Lipopolysaccharide up-regulates heat shock protein expression in rat lung pericytes.
Mechanisms of Thrombocytopenia During Septic Shock: A Multiplex Cluster Analysis of Endogenous Sepsis Mediators.
Mitochondrial membrane potential and apoptosis peripheral blood monocytes in severe human sepsis.
Pediatric Sepsis - Part V: Extracellular Heat Shock Proteins: Alarmins for the Host Immune System.
Protection against pneumococcal infection elicited by immunization with multiple pneumococcal heat shock proteins.
Radicicol, a Hsp90 inhibitor, inhibits intestinal inflammation and leakage in abdominal sepsis.
Radicicol, an Hsp90 inhibitor, inhibits intestinal inflammation and leakage in abdominal sepsis.
Release of endogenous heat shock protein 72 on the survival of sepsis in rats.
Role of sepsis in the development of limb muscle weakness in a porcine intensive care unit model.
Septicemia caused by tick-borne bacterial pathogen Candidatus Neoehrlichia mikurensis.
Similar Metabolic, Innate Immunity, and Adipokine Profiles in Adult and Pediatric Sepsis Versus Systemic Inflammatory Response Syndrome-A Pilot Study.
The association of innate immune response gene polymorphisms and puerperal group A streptococcal sepsis.
The effect of 2 mMol glutamine supplementation on HSP70 and TNF-? release by LPS stimulated blood from healthy children.
The Heat Shock Protein 70 Plays a Protective Role in Sepsis by Maintenance of the Endothelial Permeability.
The interaction between Hsp70 and TNF-alpha expression: a novel mechanism for protection of the myocardium against post-injury depression.
The role of heat shock protein 70 in mediating age-dependent mortality in sepsis.
The small heat shock protein HSPB1 protects mice from sepsis.
Thermal Steam Aerosolization Protects Against Lipopolysaccharide-Induced Sepsis in Rats.
Treatment of a critically ill child with disseminated Candida glabrata with a recombinant human antibody specific for fungal heat shock protein 90 and liposomal amphotericin B, caspofungin, and voriconazole.
Xuebijing Injection Maintains GRP78 Expression to Prevent Candida albicans-Induced Epithelial Death in the Kidney.
[Research properties of the exogenous recombinant human heat shock protein HSP70 on test rodents].
[The different effects of glutamine on macrophage cytokines release in vivo and in vitro]
Sertoli Cell Tumor
Testicular superoxide dismutase activity, heat shock protein 70 concentration and blood plasma inhibin-alpha concentration of dogs with a Sertoli cell tumor in a unilateral cryptorchid testis.
Severe Combined Immunodeficiency
Inhibition of tumor growth in mice with severe combined immunodeficiency is mediated by heat shock protein 70 (Hsp70)-peptide-activated, CD94 positive natural killer cells.
Sexually Transmitted Diseases
Induction of messenger RNA for the 70 kDa heat shock protein in HeLa cells and the human endocervix following exposure to semen: implications for antisperm antibody production and susceptibility to sexually transmitted infections.
Prevalence and correlates of antibody to chlamydial heat shock protein in women attending sexually transmitted disease clinics and women with confirmed pelvic inflammatory disease.
Shock, Septic
A toxic shock syndrome toxin-1 peptide that shows homology to amino acids 180-193 of mycobacterial heat shock protein 65 is presented as conventional antigen.
A toxic shock syndrome toxin-1 peptide that shows homology to mycobacterial heat shock protein 18 is presented as conventional antigen to T cells by multiple HLA-DR alleles.
An in vitro model to consider the effect of 2 mM glutamine and KNK437 on endotoxin-stimulated release of heat shock protein 70 and inflammatory mediators.
Exercise pretraining attenuates endotoxin-induced hemodynamic alteration in type I diabetic rats.
Exogenous heat shock cognate protein 70 pretreatment attenuates cardiac and hepatic dysfunction with associated anti-inflammatory responses in experimental septic shock.
Extracellular heat shock protein 60 (Hsp60) levels in children with septic shock.
Genetic polymorphisms in sepsis and septic shock: role in prognosis and potential for therapy.
Genetic variation in heat shock protein 70 is associated with septic shock: narrowing the association to a specific haplotype.
Glutamine induces heat shock protein and protects against endotoxin shock in the rat.
Heat shock protein 60 as a biomarker for acute kidney injury secondary to septic shock in pediatric patients, Egyptian multicenter experience.
Heat shock protein 70-2+1267 AA homozygotes have an increased risk of septic shock in adults with community-acquired pneumonia.
Heat shock protein: tracing the enemy in septic shock.
Oral administration of geranylgeranylacetone improves survival rate in a rat endotoxin shock model: administration timing and heat shock protein 70 induction.
Sickle Cell Trait
Genetic polymorphisms associated with exertional rhabdomyolysis.
Skin Diseases
A survey and analysis of the role of molecular chaperone proteins and imidazole-containing dipeptide-based compounds as molecular escorts into the skin during stress, injury, water structuring and other types of cutaneous pathophysiology.
Aberrant expression and secretion of heat shock protein 90 in patients with bullous pemphigoid.
Autoantibodies to human stress proteins. A survey of various rheumatic and other inflammatory diseases.
Biologic Activities of Molecular Chaperones and Pharmacologic Chaperone Imidazole-Containing Dipeptide-Based Compounds: Natural Skin Care Help and the Ultimate Challenge. Implication for Adaptive Responses in the Skin.
Heat shock protein 90: a pathophysiological factor and novel treatment target in autoimmune bullous skin diseases.
Topically Applied Hsp90 Blocker 17AAG Inhibits Autoantibody-Mediated Blister-Inducing Cutaneous Inflammation.
Water-structuring technology with the molecular chaperone proteins: indicated application of the ?-crystallin domains and imidazole-containing peptidomimetics in cosmetic skin care systems or dermatological therapeutic drug carrier formulations.
Skin Diseases, Vesiculobullous
Heat shock protein 90: a pathophysiological factor and novel treatment target in autoimmune bullous skin diseases.
Skin Neoplasms
17-Aminogeldanamycin Inhibits Constitutive Nuclear Factor-Kappa B (NF-?B) Activity in Patient-Derived Melanoma Cell Lines.
Heat shock transcription factor-1 regulates heat shock protein-72 expression in human keratinocytes exposed to ultraviolet B light.
In Silico Studies on Fungal Metabolite against Skin Cancer Protein (4,5-Diarylisoxazole HSP90 Chaperone).
Sleep Apnea, Obstructive
Assessment of oxidative stress markers and hearing thresholds in patients with obstructive sleep apnea-hypopnoea treated with cysteine and superoxide dismutase therapy.
Heat shock protein 72 level decreases during sleep in patients with obstructive sleep apnea syndrome.
Hypoxia-sensitive molecules may modulate the development of atherosclerosis in sleep apnoea syndrome.
Sleep Deprivation
Acute sleep deprivation induces cardioprotection against ischemia/ reperfusion injury through reducing inflammatory responses: the role of central GABA-A receptors.
Differential increase in the expression of heat shock protein family members during sleep deprivation and during sleep.
Does the compromised sleep and circadian disruption of night and shiftworkers make them highly vulnerable to 2019 coronavirus disease (COVID-19)?
Gene expression in the brain across the sleep-waking cycle.
Gene expression in the rat brain during sleep deprivation and recovery sleep: an Affymetrix GeneChip(R) study.
Gene expression in the rat cerebral cortex: comparison of recovery sleep and hypnotic-induced sleep.
Geranylgeranylacetone, an inducer of HSP 70, attenuates REM sleep rebound after sleep deprivation.
Sleep deprivation increase the expression of inducible heat shock protein 70 in rat gastric mucosa.
[Study of the protective effects of exogenous heat shock protein 70 kDa in the model of sleep deprivation in pigeons Columba livia].
Small Cell Lung Carcinoma
A Novel HSP90 Inhibitor-Drug Conjugate to SN38 Is Highly Effective in Small Cell Lung Cancer.
Differential expression of heat shock protein 90 isoforms in small cell lung cancer.
Down-regulation of GRP78 is associated with the sensitivity of chemotherapy to VP-16 in small cell lung cancer NCI-H446 cells.
Heat shock protein 90 inhibition in lung cancer.
HSP90 inhibitor (NVP-AUY922) enhances the anti-cancer effect of BCL-2 inhibitor (ABT-737) in small cell lung cancer expressing BCL-2.
Induction of premature senescence by hsp90 inhibition in small cell lung cancer.
Organ-specific efficacy of HSP90 inhibitor in multiple-organ metastasis model of chemorefractory small cell lung cancer.
Serum Heat Shock Protein 70, as a Potential Biomarker for Small Cell Lung Cancer.
Tumor cell expression of heat shock protein (HSP) 72 is influenced by HSP72 [HSPA1B A(1267)G] polymorphism and predicts survival in small Cell lung cancer (SCLC) patients.
Tumor-targeted SN38 inhibits growth of early stage non-small cell lung cancer (NSCLC) in a KRas/p53 transgenic mouse model.
Spastic Paraplegia, Hereditary
A cell model to study different degrees of Hsp60 deficiency in HEK293 cells.
An allosteric network in spastin couples multiple activities required for microtubule severing.
Decreased expression of the mitochondrial matrix proteases Lon and ClpP in cells from a patient with hereditary spastic paraplegia (SPG13).
Hereditary spastic paraplegia SPG13 is associated with a mutation in the gene encoding the mitochondrial chaperonin Hsp60.
MitCHAP-60 and Hereditary Spastic Paraplegia SPG-13 Arise from an Inactive hsp60 Chaperonin that Fails to Fold the ATP Synthase ?-Subunit.
The Drosophila homologue of the hereditary spastic paraplegia protein, spastin, severs and disassembles microtubules.
The Hsp60 folding machinery is crucial for manganese superoxide dismutase folding and function.
The Hsp60-(p.V98I) mutation associated with hereditary spastic paraplegia SPG13 compromises chaperonin function both in vitro and in vivo.
Spinal Cord Injuries
Distinct Expression of c-Jun and HSP27 in Axotomized and Spared Bulbospinal Neurons After Cervical Spinal Cord Injury.
Exercise preconditioning protects against spinal cord injury in rats by upregulating neuronal and astroglial heat shock protein 72.
Expression of the stress proteins, ubiquitin, heat shock protein 72, and myofibrillar protein content after 12 weeks of leg cycling in persons with spinal cord injury.
Loss of hsp70.1 Decreases Functional Motor Recovery after Spinal Cord Injury in Mice.
Matrine promotes neural circuit remodeling to regulate motor function in a mouse model of chronic spinal cord injury.
MEK1/2 Inhibition Synergistically Enhances the Preventive Effects of Normobaric Oxygen on Spinal Cord Injury in Decompression Sickness Rats.
Nanoparticles Exacerbate Both Ubiquitin and Heat Shock Protein Expressions in Spinal Cord Injury: Neuroprotective Effects of the Proteasome Inhibitor Carfilzomib and the Antioxidant Compound H-290/51.
Neurotrophic factors influence upregulation of constitutive isoform of heme oxygenase and cellular stress response in the spinal cord following trauma. An experimental study using immunohistochemistry in the rat.
Nitration of Hsp90 induces cell death.
Presence and activation of pro-inflammatory macrophages are associated with CRYAB expression in vitro and after peripheral nerve injury.
Spinal cord injury induced heat shock protein expression is reduced by an antioxidant compound H-290/51. An experimental study using light and electron microscopy in the rat.
The change tendency of endoplasmic reticulum stress associated proteins in rats with spinal cord injury.
Time-dependent changes in caspase-3 activity and heat shock protein 25 after spinal cord transection in adult rats.
[Effect of tacrolimus on apoptosis and expression of heat shock protein 70 after acute spinal cord injury in rats]
Spinal Cord Ischemia
Effect of ischemic pretreatment on heat shock protein 72, neurologic outcome, and histopathologic outcome in a rabbit model of spinal cord ischemia.
Establishment of a local cooling model against spinal cord ischemia representing prolonged induction of heat shock protein.
Selective motor neuron death and heat shock protein induction after spinal cord ischemia in rabbits.
Spinocerebellar Ataxias
Altered expression of HSPA5, HSPA8 and PARK7 in spinocerebellar ataxia type 17 identified by 2-dimensional fluorescence difference in gel electrophoresis.
Analysis of the role of heat shock protein (Hsp) molecular chaperones in polyglutamine disease.
BIIB021, a synthetic Hsp90 inhibitor, induces mutant ataxin-1 degradation through the activation of heat shock factor 1.
HSP27 and cell death in spinocerebellar ataxia type 3.
Increased heat shock transcription factor 1 in the cerebellum reverses the deficiency of Purkinje cells in Alzheimer's disease.
Over-expression of inducible HSP70 chaperone suppresses neuropathology and improves motor function in SCA1 mice.
Transcriptional malfunctioning of heat shock protein gene expression in spinocerebellar ataxias.
Trehalose induces autophagy via lysosomal-mediated TFEB activation in models of motoneuron degeneration.
Upregulation of miR-370 and miR-543 is associated with reduced expression of heat shock protein 40 in spinocerebellar ataxia type 3.
Spondylarthropathies
Heat shock protein 70 gene polymorphisms in Mexican patients with spondyloarthropathies.
Spondyloarthropathies and bone resorption: a possible role of heat shock protein (Hsp70).
Spondylitis, Ankylosing
Anti-mutated citrullinated vimentin (anti-MCV) and anti-65kDa heat shock protein (anti-hsp65): New biomarkers in ankylosing spondylitis.
Cellular immune response to Klebsiella pneumoniae antigens in patients with HLA-B27+ ankylosing spondylitis.
Serum antibodies from patients with ankylosing spondylitis and Reiter's syndrome are reactive with HLA-B27 cells transfected with the Mycobacterium tuberculosis hsp60 gene.
T cell response to human HSP60 and yersinia 19 kDa in ankylosing spondylitis and rheumatoid arthritis: no evidence for a causal role of these antigens in the pathogenesis.
Upregulation of 78-kDa glucose-regulated protein in macrophages in peripheral joints of active ankylosing spondylitis.
[Relationship between heat shock protein 70-hom gene polymorphism and ankylosing spondylitis]
[The heat shock protein 70-2 gene +1267(A/G)polymorphism and susceptibility to ankylosing spondylitis in Chinese Han population.]
Spotted Fever Group Rickettsiosis
Molecular detection and groEL typing of Rickettsia aeschlimannii in Sardinian ticks.
Molecular epidemic survey on co-prevalence of scrub typhus and marine typhus in Yuxi city, Yunnan province of China.
Squamous Cell Carcinoma of Head and Neck
2-phenylethynesulfonamide inhibits growth of oral squamous cell carcinoma cells by blocking the function of heat shock protein 70.
2D-DIGE proteomic characterization of head and neck squamous cell carcinoma.
A microRNA-27a mimic sensitizes human oral squamous cell carcinoma HSC-4 cells to hyperthermia through downregulation of Hsp110 and Hsp90.
A novel intronic circular RNA, circGNG7, inhibits head and neck squamous cell carcinoma progression by blocking the phosphorylation of heat shock protein 27 at Ser78 and Ser82.
Antitumor effect of novel HSP90 inhibitor NVP-AUY922 against oral squamous cell carcinoma.
BIIB021, a novel HSP90 inhibitor, sensitizes head and neck squamous cell carcinoma to radiotherapy.
CD20+ Tumor Infiltrating B Lymphocyte in Oral Squamous Cell Carcinoma: Correlation with Clinicopathologic Characteristics and Heat Shock Protein 70 Expression.
Decreased GRP78 protein expression is a potential prognostic marker of oral squamous cell carcinoma in Taiwan.
Dysregulation of heat shock protein 27 expression in oral tongue squamous cell carcinoma.
Effect of 17-allylamino-17-demethoxygeldanamycin (17-AAG) on Akt protein expression is more effective in head and neck cancer cell lineages that retain PTEN protein expression.
Effect of hypoxia on the expression of alphaB-crystallin in head and neck squamous cell carcinoma.
Elimination of head and neck cancer initiating cells through targeting glucose regulated protein78 signaling.
Emphasizing on heat shock protein 90's utility in head and neck squamous cell carcinoma treatment.
Expression of Heat Shock Protein 70 in Oral Epithelial Dysplasia and Oral Squamous Cell Carcinoma: An Immunohistochemical Study.
Expression of heat shock protein70 in oral submucous fibrosis and oral squamous cell carcinoma: an immunohistochemical study.
Expression pattern of heat shock protein 90 in patients with oral squamous cell carcinoma in northern Taiwan.
Extracellular heat shock protein A9 is a novel interaction partner of podoplanin in oral squamous cell carcinoma cells.
Heat Shock Protein 27 as a New Therapeutic Target for Radiation Sensitization of Head and Neck Squamous Cell Carcinoma.
Heat shock protein 27 expression in areca quid chewing-associated oral squamous cell carcinomas.
Heat shock protein 47 expression in oral squamous cell carcinomas and upregulated by arecoline in human oral epithelial cells.
Heat shock protein 90 (HSP90) is overexpressed in p16-negative oropharyngeal squamous cell carcinoma, and its inhibition in vitro potentiates the effects of chemoradiation.
Heat shock protein and p53 expression in head and neck squamous cell carcinoma.
High glucose uptake unexpectedly is accompanied by high levels of the mitochondrial ß-F1-ATPase subunit in head and neck squamous cell carcinoma.
HSP105 expression in oral squamous cell carcinoma: Correlation with clinicopathological features and outcomes.
HSP90 inhibition sensitizes head and neck cancer to platin-based chemoradiotherapy by modulation of the DNA damage response resulting in chromosomal fragmentation.
HSP90 Inhibitor SNX5422/2112 Targets the Dysregulated Signal and Transcription Factor Network and Malignant Phenotype of Head and Neck Squamous Cell Carcinoma.
Hypoxia-inducible factor 1alpha and antiangiogenic activity of farnesyltransferase inhibitor SCH66336 in human aerodigestive tract cancer.
Identification of potential biomarkers of head and neck squamous cell carcinoma using iTRAQ based quantitative proteomic approach.
Low-Dose Hsp90 Inhibitor Selectively Radiosensitizes HNSCC and Pancreatic Xenografts.
Novel C-Terminal Heat Shock Protein 90 Inhibitors (KU711 and Ku757) Are Effective in Targeting Head and Neck Squamous Cell Carcinoma Cancer Stem cells.
Novel C-Terminal Hsp90 Inhibitor for Head and Neck Squamous Cell Cancer (HNSCC) with in vivo Efficacy and Improved Toxicity Profiles Compared with Standard Agents.
Novel HSP90 Inhibitor NVP-AUY922 enhances the anti-tumor effect of temsirolimus against oral squamous cell carcinoma.
Overexpression of heat shock protein 27 (HSP-27) is associated with bad prognosis in oral squamous cell carcinoma.
Overexpression of heat shock protein 27 is associated with good prognosis in the patient with oral squamous cell carcinoma.
P53-dependent radiosensitizing effects of Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin on human oral squamous cell carcinoma cell lines.
Pharmacological inhibition of HSP90 and ras activity as a new strategy in the treatment of HNSCC.
Pharmacological Inhibition of HSP90 Radiosensitizes Head and Neck Squamous Cell Carcinoma Xenograft by Inhibition of DNA Damage Repair, Nucleotide Metabolism, and Radiation-Induced Tumor Vasculogenesis.
Potent activity of a novel dimeric heat shock protein 90 inhibitor against head and neck squamous cell carcinoma in vitro and in vivo.
Prognostic significance of heat shock protein 27 (HSP27) in patients with oral squamous cell carcinoma.
Proteome-wide analysis of head and neck squamous cell carcinomas using laser-capture microdissection and tandem mass spectrometry.
Synergistic effect of heat shock protein 90 inhibitor, 17-allylamino-17-demethoxygeldanamycin and X-rays, but not carbon-ion beams, on lethality in human oral squamous cell carcinoma cells.
Targeted therapy in head and neck cancer.
The upregulation of heat shock protein 70 expression in areca quid chewing-associated oral squamous cell carcinomas.
Triple knockdown of CDC37, HSP90-alpha and HSP90-beta diminishes extracellular vesicles-driven malignancy events and macrophage M2 polarization in oral cancer.
[Biology behavior of head and neck squamous cell cancer cells changes after knocking down heat shock protein 27].
ST Elevation Myocardial Infarction
Expression of Circulatory Dendritic Cells and Regulatory T-Cells in Patients with Different Subsets of Coronary Artery Disease.
Starvation
?III-Tubulin alters glucose metabolism and stress response signaling to promote cell survival and proliferation in glucose-starved non-small cell lung cancer cells.
A proteome analysis of the tetracyanonickelate (II) responses in Klebsiella oxytoca.
A Single Site Phosphorylation on Hsp82 Ensures Cell Survival during Starvation in Saccharomyces cerevisiae.
A Triterpene Lactone from Callistemon citrinus Inhibits the PANC-1 Human Pancreatic Cancer Cells Viability through Suppression of Unfolded Protein Response.
ADP-ribosylation of the 78-kDa glucose-regulated protein during nutritional stress.
ADP-ribosylation of the molecular chaperone GRP78/BiP.
Alcohol alters skeletal muscle heat shock protein gene expression in rats: these effects are moderated by sex, raised endogenous acetaldehyde, and starvation.
Alteration of cell morphology and viability in a recA mutant of Streptococcus thermophilus upon induction of heat shock and nutrient starvation.
An analogue of the DnaJ molecular chaperone whose expression is controlled by sigma s during the stationary phase and phosphate starvation in Escherichia coli.
An Hsp70-like protein in the ER: identity with the 78 kd glucose-regulated protein and immunoglobulin heavy chain binding protein.
Arctigenin Suppresses Unfolded Protein Response and Sensitizes Glucose Deprivation-Mediated Cytotoxicity of Cancer Cells.
Calreticulin--a stress protein induced in the renal epithelial cell line NBL-1 by amino acid deprivation.
Cloning and expression pattern of heat shock protein genes from the endoparasitoid wasp, Pteromalus puparum in response to environmental stresses.
Complementary autophagy inhibition and glucose metabolism with rattle-structured polydopamine@mesoporous silica nanoparticles for augmented low-temperature photothermal therapy and in vivo photoacoustic imaging.
Development of antitumor biguanides targeting energy metabolism and stress responses in the tumor microenvironment.
Differential expression of heat shock proteins and antioxidant enzymes in response to temperature, starvation, and parasitism in the Carob moth larvae, Ectomyelois ceratoniae (Lepidoptera: Pyralidae).
Down-regulation of epidermal growth factor receptor-signaling pathway by binding of GRP78/BiP to the receptor under glucose-starved stress conditions.
Ectopic expression of a cyanobacterial flavodoxin in creeping bentgrass impacts plant development and confers broad abiotic stress tolerance.
Effectiveness of HSV-tk suicide gene therapy driven by the Grp78 stress-inducible promoter in esophagogastric junction and gastric adenocarcinomas.
Effects of aquarium-related stressors on the zebrafish: a comparison of behavioral, physiological, and biochemical indicators.
Enhanced hydrogen peroxide sensitivity and altered stress protein expression in iron-starved Mycobacterium smegmatis.
Environment-induced same-sex mating in the yeast Candida albicans through the Hsf1-Hsp90 pathway.
Expression pattern of potential biomarker genes related to growth, ion regulation and stress in response to ammonia exposure, food deprivation and exercise in common carp (Cyprinus carpio).
Glucose regulation of GRP78 gene expression.
Growth-Regulated Hsp70 Phosphorylation Regulates Stress Responses and Prion Maintenance.
GRP78/BiP inhibits endoplasmic reticulum BIK and protects human breast cancer cells against estrogen starvation-induced apoptosis.
Heat shock protein-90-alpha, a prolactin-STAT5 target gene identified in breast cancer cells, is involved in apoptosis regulation.
HHQ-4, a quinoline derivate, preferentially inhibits proliferation of glucose-deprived breast cancer cells as a GRP78 down-regulator.
Hsp90 binds and regulates Gcn2, the ligand-inducible kinase of the alpha subunit of eukaryotic translation initiation factor 2 [corrected]
Immunoproteomic identification of antigenic candidate Campylobacter jejuni and human peripheral nerve proteins involved in Guillain-Barré syndrome.
Increased Macroautophagy in the Pathological Process of Intervertebral Disc Degeneration in Rats.
Induced expression of the heat shock protein genes uspA and grpE during starvation at low temperatures and their influence on thermal resistance of Escherichia coli O157:H7.
Inducible knockout of GRP78/BiP in the hematopoietic system suppresses Pten-null leukemogenesis and AKT oncogenic signaling.
Involvement of heat shock protein (Hsp)90 beta but not Hsp90 alpha in antiapoptotic effect of CpG-B oligodeoxynucleotide.
Ischemia activates the ATF6 branch of the endoplasmic reticulum (ER) stress response.
Knockdown of ERp44 leads to apoptosis via activation of ER stress in HeLa cells.
Light-activated oxygen self-supplied starving therapy in near-infrared (NIR) window and adjuvant hyperthermia-induced tumor ablation with an augmented sensitivity.
Metabolic modulation in Labeo rohita fingerlings during starvation: Hsp70 expression and oxygen consumption
Mitochondrial nucleoids undergo remodeling in response to metabolic cues.
Molecular analysis of a glucose-regulated gene (grp78) of Neurospora crassa.
Molecular cloning of the heat-shock cognate 70 (Hsc70) gene from the two-spotted spider mite, Tetranychus urticae, and its expression in response to heat shock and starvation.
Overexpression of GRP78 and GRP94 are markers for aggressive behavior and poor prognosis in gastric carcinomas.
Overexpression of GRP78 and GRP94 is involved in colorectal carcinogenesis.
Phosphorylation of GroEL, DnaK and other proteins from Thiobacillus ferrooxidans grown under different conditions.
Phosphorylation of Heat Shock Protein 27 is Increased by Cast Immobilization and by Serum-free Starvation in Skeletal Muscles.
Potentiation of chemotherapeutics by the Hsp90 antagonist geldanamycin requires a steady serum condition.
Proteomic Analysis of Larval Midgut from the Silkworm (Bombyx mori).
Pyrvinium targets the unfolded protein response to hypoglycemia and its anti-tumor activity is enhanced by combination therapy.
Quantitative proteomics identifies unanticipated regulators of nitrogen- and glucose starvation.
Regulation of HSP60 mRNA expression in a human ovarian carcinoma cell line.
Reversible ADP-ribosylation of the 78 kDa glucose-regulated protein.
Role of RpoH, a heat shock regulator protein, in Escherichia coli carbon starvation protein synthesis and survival.
Secreted heat shock protein 90alpha induces colorectal cancer cell invasion through CD91/LRP-1 and NF-kappaB-mediated integrin alphaV expression.
Spontaneous and controllable activation of suicide gene expression driven by the stress-inducible grp78 promoter resulting in eradication of sizable human tumors.
Structural insights into the Escherichia coli lysine decarboxylases and molecular determinants of interaction with the AAA+ ATPase RavA.
Targeting HSP90/Survivin using a cell permeable structure based peptido-mimetic shepherdin in retinoblastoma.
Temporal changes in superoxide dismutase, catalase, and heat shock protein 70 gene expression, cortisol and antioxidant enzymes activity of Labeo rohita fingerlings subjected to starvation and refeeding.
The unfolded protein response regulator GRP78/BiP is required for endoplasmic reticulum integrity and stress-induced autophagy in mammalian cells.
Transcriptional activation of the glucose-regulated protein genes and their heterologous fusion genes by beta-mercaptoethanol.
Use of the glucose starvation-inducible glucose-regulated protein 78 promoter in suicide gene therapy of murine fibrosarcoma.
V-ATPase dysfunction suppresses polyphosphate synthesis in Saccharomyces cerevisiae.
Zim17/Tim15 links mitochondrial iron-sulfur cluster biosynthesis to nuclear genome stability.
[Expression analysis of 5 hsp70 genes in Tetrahymena thermophila].
[Molecular chaperone GRP75 reprove cells from injury caused by glucose deprivation]
Status Epilepticus
Epileptogenesis-Associated Alterations of Heat Shock Protein 70 in a Rat Post-Status Epilepticus Model.
Expression of the 27,000 mol. wt heat shock protein following kainic acid-induced status epilepticus in the rat.
Heat shock protein 70 protects against seizure-induced neuronal cell death in the hippocampus following experimental status epilepticus via inhibition of nuclear factor-?B activation-induced nitric oxide synthase II expression.
Induction of glucose-regulated protein (glucose-regulated protein 78/BiP and glucose-regulated protein 94) and heat shock protein 70 transcripts in the immature rat brain following status epilepticus.
P2RX7-MAPK1/2-SP1 axis inhibits MTOR independent HSPB1-mediated astroglial autophagy.
Reduction in heat shock protein 90 correlates to neuronal vulnerability in the rat piriform cortex following status epilepticus.
Strain-dependent effects of long-term treatment with melatonin on kainic acid-induced status epilepticus, oxidative stress and the expression of heat shock proteins.
The 27-kDa heat shock protein (HSP27) is a reliable hippocampal marker of full development of pilocarpine-induced status epilepticus.
Stomach Diseases
Heat shock protein: hard worker or bad offender for gastric diseases.
Quantitative analysis of representative proteome components and clustering of Helicobacter pylori clinical strains.
[The virtuoueffect of heat shock protein 70 and evil effect of nuclear factor-kappa B in patients with chronic gastric disease of PI-Wie damp-heat syndrome type]
Stomach Neoplasms
3,3'-diindolylmethane potentiates tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis of gastric cancer cells.
A genetic variant in the gene encoding the stress70 protein chaperone family member STCH is associated with gastric cancer in the Japanese population.
A new tumor-specific variant of GRP78 as target for antibody-based therapy.
A peptide derived from phage display library exhibits anti-tumor activity by targeting GRP78 in gastric cancer multidrug resistance cells.
A virulence factor of Helicobacter pylori: role of heat shock protein in mucosal inflammation after H. pylori infection.
Antibody response to Helicobacter pylori CagA and heat-shock proteins in determining the risk of gastric cancer development.
Antitumor activity of NVP-AUY922, a novel heat shock protein 90 inhibitor, in human gastric cancer cells is mediated through proteasomal degradation of client proteins.
Association between Polymorphisms in Inflammatory Response-Related Genes and the Susceptibility, Progression and Prognosis of the Diffuse Histological Subtype of Gastric Cancer.
Association of elevated GRP78 expression with increased lymph node metastasis and poor prognosis in patients with gastric cancer.
Blocking heat shock protein-90 inhibits the invasive properties and hepatic growth of human colon cancer cells and improves the efficacy of oxaliplatin in p53-deficient colon cancer tumors in vivo.
Caveolin-1 promotes gastric cancer progression by up-regulating epithelial to mesenchymal transition by crosstalk of signalling mechanisms under hypoxic condition.
Cellular stress and redox activity proteins are involved in gastric carcinogenesis associated with Helicobacter pylori infection expressing high levels of thioredoxin-1.
Clinical significance of heat shock protein 90? expression as a biomarker of prognosis in patients with gastric cancer.
Clinical significance of heat shock proteins in gastric cancer following hyperthermia stress: Indications for hyperthermic intraperitoneal chemoperfusion therapy.
Clinicopathological Significance of Heat Shock Protein (HSP) 27 Expression in Gastric Cancer: A Updated Meta-Analysis.
Comparative proteomics analysis of gastric cancer stem cells.
Correlation of fragile histidine triad (Fhit) protein structural features with effector interactions and biological functions.
Decreased expression of the carboxyl terminus of heat shock cognate 70 interacting protein in human gastric cancer and its clinical significance.
Decreased functional expression of Grp78 and Grp94 inhibits proliferation and attenuates apoptosis in a human gastric cancer cell line in vitro.
Diagnostic and prognostic value of plasma heat shock protein 90alpha in gastric cancer.
Diagnostic, clinicopathologic, therapeutic and prognostic value of Plasma Heat Shock Protein 90 levels in patients with advanced Gastrointestinal Carcinoma.
Discovery of tumor markers for gastric cancer by proteomics.
Down-regulation of Hsp90 could change cell cycle distribution and increase drug sensitivity of tumor cells.
Efrapeptin J, a new down-regulator of the molecular chaperone GRP78 from a marine Tolypocladium sp.
Endoplasmic reticulum chaperone glucose-regulated protein 78 in gastric cancer: An emerging biomarker.
Enhanced invasive and metastatic potential induced by transforming growth factor-beta1 might be correlated with glutathione-S-transferase-pi, cofilin and heat shock protein 27 in SGC-7901 gastric cancer cells.
Estrogen receptor-?36-mediated rapid estrogen signaling regulates 78 kDa glucose-regulated protein expression in gastric carcinoma cells.
Exosomal circSHKBP1 promotes gastric cancer progression via regulating the miR-582-3p/HUR/VEGF axis and suppressing HSP90 degradation.
Expression of GRP78 predicts taxane-based therapeutic resistance and recurrence of human gastric cancer.
Expression of heat shock protein (Hsp) 70 and Hsp 40 in gastric cancer.
Expression of heat shock protein 90 beta in human gastric cancer tissue and SGC7901/VCR of MDR-type gastric cancer cell line.
Expression of the 27-kDa heat shock protein (HSP27) in gastric carcinomas and adjacent normal, metaplastic, and dysplastic gastric mucosa, and its prognostic significance.
GALNT5 uaRNA promotes gastric cancer progression through its interaction with HSP90.
Ganetespib induces G2/M cell cycle arrest and apoptosis in gastric cancer cells through targeting of receptor tyrosine kinase signaling.
Gastric cancer-derived heat shock protein-gp96 peptide complex enhances dendritic cell activation.
Geldanamycin induces apoptosis in human gastric carcinomas by affecting multiple oncogenic kinases that have synergic effects with TNF-related apoptosis-inducing ligand.
GKN2 promotes oxidative stress-induced gastric cancer cell apoptosis via the Hsc70 pathway.
GRP78 positively regulates estrogen?stimulated cell growth mediated by ER??36 in gastric cancer cells.
Heat shock protein 22 overexpression is associated with the progression and prognosis in gastric cancer.
Heat shock protein 27 downstream of P38-PI3K/Akt signaling antagonizes melatonin-induced apoptosis of SGC-7901 gastric cancer cells.
Heat shock protein 60 overexpression is associated with the progression and prognosis in gastric cancer.
Heat shock protein 70 (HSP70) expression is associated with poor prognosis in intestinal type gastric cancer.
Heat shock protein 70 antisense oligonucleotide inhibits cell growth and induces apoptosis in human gastric cancer cell line SGC-7901.
Heat Shock Protein Association with Clinico-Pathological Characteristics of Gastric Cancer in Jordan : HSP70 is Predictive of Poor Prognosis.
Heat-directed suicide gene therapy mediated by heat shock protein promoter for gastric cancer.
Heat-shock protein 60 homologue of Helicobacter pylori is associated with adhesion of H. pylori to human gastric epithelial cells.
Helicobacter pylori blood biomarker for gastric cancer risk in East Asia.
Helicobacter pylori heat shock protein 60 antibodies are associated with gastric cancer.
Helicobacter pylori promotes apoptosis, activates cyclooxygenase (COX)-2 and inhibits heat shock protein HSP70 in gastric cancer epithelial cells.
High expression of heat shock protein 90 is associated with tumor aggressiveness and poor prognosis in patients with advanced gastric cancer.
Honokiol induces calpain-mediated glucose-regulated protein-94 cleavage and apoptosis in human gastric cancer cells and reduces tumor growth.
HSP90 inhibitor 17-DMAG exerts anticancer effects against gastric cancer cells principally by altering oxidant-antioxidant balance.
HSP90 inhibitor, AUY922, debilitates intrinsic and acquired lapatinib-resistant HER2-positive gastric cancer cells.
In vitro Cytotoxic Activities of the Oral Platinum(IV) Prodrug Oxoplatin and HSP90 Inhibitor Ganetespib against a Panel of Gastric Cancer Cell Lines.
Induction of a tumour-specific CTL response by exosomes isolated from heat-treated malignant ascites of gastric cancer patients.
Induction of glucose-regulated protein 78 by chronic hypoxia in human gastric tumor cells through a protein kinase C-epsilon/ERK/AP-1 signaling cascade.
Inhibition of gastric tumor growth by a novel Hsp90 inhibitor.
Inhibition of heat shock protein 90 impairs epidermal growth factor-mediated signaling in gastric cancer cells and reduces tumor growth and vascularization in vivo.
Inhibition of HSP90 with AUY922 Induces Synergy in HER2-Amplified Trastuzumab-Resistant Breast and Gastric Cancer.
Inhibition of MEK blocks GRP78 up-regulation and enhances apoptosis induced by ER stress in gastric cancer cells.
Is co-expression of USP22 and HSP90 more effective in predicting prognosis of gastric cancer?
KIAA1324 Suppresses Gastric Cancer Progression by Inhibiting the Oncoprotein GRP78.
Leptin and fasting regulate rat gastric glucose-regulated protein 58.
Mechanism study of peptide GMBP1 and its receptor GRP78 in modulating gastric cancer MDR by iTRAQ-based proteomic analysis.
Mortalin is a prognostic factor of gastric cancer with normal p53 function.
Neocurromycin A, a new GRP78 downregulator from Streptomyces sp. RAI364.
NLRP6 suppresses gastric cancer growth via GRP78 ubiquitination.
Novel targeted nuclear imaging agent for gastric cancer diagnosis: glucose-regulated protein 78 binding peptide-guided 111In-labeled polymeric micelles.
Nuclear heat shock protein 110 expression is associated with poor prognosis and chemotherapy resistance in gastric cancer.
Nuclear heat shock protein 110 expression is associated with poor prognosis and hyperthermo-chemotherapy resistance in gastric cancer patients with peritoneal metastasis.
Oncogenic MST1R activity in pancreatic and gastric cancer represents a valid target of HSP90 inhibitors.
Overexpression of the heat shock protein HSP70 family and p53 protein and prognosis for patients with gastric cancer.
Plasminogen kringle 5 suppresses gastric cancer via regulating HIF-1? and GRP78.
Polymorphisms in TNF and HSP-70 show a significant association with gastric cancer and duodenal ulcer.
Preclinical antitumor activity of the novel heat shock protein 90 inhibitor CH5164840 against human epidermal growth factor receptor 2 (HER2)-overexpressing cancers.
Protection of stromal cell-derived factor 2 by heat shock protein 72 prevents oxaliplatin-induced cell death in oxaliplatin-resistant human gastric cancer cells.
Protective role of genetic polymorphism of heat shock protein 70-2 for gastric cancer risk.
Proteomics-based identification of a tumor-associated antigen and its corresponding autoantibody in gastric cancer.
RNA interference-mediated silencing of the Hsp70 gene inhibits human gastric cancer cell growth and induces apoptosis in vitro and in vivo.
Salidroside inhibits the proliferation and migration of gastric cancer cells via suppression of Src?associated signaling pathway activation and heat shock protein 70 expression.
Significance of expression of heat shock protein90alpha in human gastric cancer.
Sodium Channel Subunit SCNN1B Suppresses Gastric Cancer Growth and Metastasis via GRP78 Degradation.
Targeting heat-shock protein 90 with ganetespib for molecularly targeted therapy of gastric cancer.
The Clinical Value of HSP60 in Digestive System Cancers: a Systematic Review and Meta-Analysis.
The cytomegalovirus protein UL138 induces apoptosis of gastric cancer cells by binding to heat shock protein 70.
The meta and bioinformatics analysis of GRP78 expression in gastric cancer.
The proteomics approach to find biomarkers in gastric cancer.
The tumor promoting roles of HSP60 and HIF2? in gastric cancer cells.
Verteporfin blocks Clusterin which is required for survival of gastric cancer stem cell by modulating HSP90 function.
[Effects of HSP90 inhibitor 17-AAG on cell cycle and apoptosis of human gastric cancer cell lines SGC-7901].
[Preparation of chaperone-antigen peptide vaccine derived from human gastric cancer stem cells and its immune function].
[Triptolide reverses apatinib resistance in gastric cancer cell line MKN45 via inhibition of heat shock protein 70].
Stomach Ulcer
Combined application of geranylgeranylacetone and amelogenin promotes angiogenesis and wound healing in human periodontal ligament cells.
Endoplasmic reticulum stress response is involved in the pathogenesis of stress induced gastric lesions in rats.
Heat Shock Protein A4 Controls Cell Migration and Gastric Ulcer Healing.
Impaired gastric ulcer healing in diabetic rats: role of heat shock protein, growth factors, prostaglandins and proinflammatory cytokines.
Overexpression of heat shock protein 70 in stomach of stress-induced gastric ulcer-resistant rats.
Role of heat shock proteins in gastric inflammation and ulcer healing.
Russelioside B; A pregnane glycoside for treatment of gastric ulcer via modulation of heat shock protein-70 and vascular endothelial growth factor.
Stimulation of gastric ulcer healing by heat shock protein 70.
Stomatitis, Aphthous
Behçet's disease and antibody titers to various heat-shock protein 60s.
Defining a T-cell epitope within HSP 65 in recurrent aphthous stomatitis.
Strabismus
Binding of the cyclophilin 40 ortholog SQUINT to Hsp90 protein is required for SQUINT function in Arabidopsis.
Streptococcal Infections
Molecular cloning, purification and immunological responses of recombinants GroEL and DnaK from Streptococcus pyogenes.
Stroke
70-kDa Heat Shock Protein Downregulates Dynamin in Experimental Stroke: A New Therapeutic Target?
A prospective evaluation of the heat shock protein 70 gene polymorphisms and the risk of stroke.
Anti-inflammatory effects of the 70 kDa heat shock protein in experimental stroke.
Atherosclerosis as a paradigmatic disease of the elderly: role of the immune system.
C-Terminus of HSC70 Interacting Protein Increases Following Stroke and Impairs Survival Against Acute Oxidative Stress.
Calorie restriction and stroke.
Can L-glutamine augmented heat shock protein 70 expression prevent exercise-induced exertional heat stroke and sudden cardiac death?
Cerebrovascular dysfunction is an attractive target for therapy in heat stroke.
Characterization of heat shock protein 27 in extracellular vesicles: a potential anti-inflammatory therapy.
Cofilin-actin rod formation in experimental stroke is attenuated by therapeutic hypothermia and overexpression of the inducible 70 kD inducible heat shock protein (Hsp70).
Decreasing or increasing heat shock protein 72 exacerbates or attenuates heat-induced cell death, respectively, in rat hypothalamic cells.
Diazoxide increases liver and kidney HSP25 and HSP70 after shock and stroke.
Differential neuroprotection from human heat shock protein 70 overexpression in in vitro and in vivo models of ischemia and ischemia-like conditions.
Dimeric heat shock protein 40 binds radial spokes for generating coupled power strokes and recovery strokes of 9 + 2 flagella.
Effects of heat shock protein 72 (Hsp72) on evolution of astrocyte activation following stroke in the mouse.
Exercise preconditioning reduces neuronal apoptosis in stroke by up-regulating heat shock protein-70 (heat shock protein-72) and extracellular-signal-regulated-kinase 1/2.
Gene therapy with HSP72 is neuroprotective in rat models of stroke and epilepsy.
Genome-wide association study of myocardial infarction, atrial fibrillation, acute stroke, acute kidney injury and delirium after cardiac surgery - a sub-analysis of the RIPHeart-Study.
Heat shock protein 70 and AMP-activated protein kinase contribute to 17-DMAG-dependent protection against heat stroke.
Heat shock protein linked to stroke protection.
Heat shock proteins and neuroprotection.
Immune-mediated mechanisms of endothelial damage in atherosclerosis.
Intrathecal heat shock protein 60 mediates neurodegeneration and demyelination in the CNS through a TLR4- and MyD88-dependent pathway.
Localization of 70-kDa stress protein induction in gerbil brain after ischemia.
Micro-RNA-30a regulates ischemia-induced cell death by targeting heat shock protein HSPA5 in primary cultured cortical neurons and mouse brain after stroke.
miR-181 regulates GRP78 and influences outcome from cerebral ischemia in vitro and in vivo.
Molecular chaperones: Toward new therapeutic tools.
Molecular targets in cerebral ischemia for developing novel therapeutics.
Neuron-Specific Enolase, S100 Calcium-Binding Protein B, and Heat Shock Protein 70 Levels in Patients With Intracranial Hemorrhage.
Novel inflammatory biomarkers and their correlation to Chlamydia pneumoniae titres in acute ischemic stroke.
Overexpression of heat shock protein 72 attenuates NF-?B activation using a combination of regulatory mechanisms in microglia.
Oxidative stress and ischemic injuries in heat stroke.
Presence and activation of pro-inflammatory macrophages are associated with CRYAB expression in vitro and after peripheral nerve injury.
Presence of heat shock protein 70 in secondary lymphoid tissue correlates with stroke prognosis.
Role of Cytotoxic Protease Granzyme-b in Neuronal Degeneration during Human Stroke.
Serum High-Sensitivity C-Reactive Protein and Heat Shock Protein 27 Antibody Titers in Patients With Stroke and 6-Month Prognosis.
Serum levels of heat shock protein 27 in patients with acute ischemic stroke.
Stem Cell-Like Dog Placenta Cells Afford Neuroprotection against Ischemic Stroke Model via Heat Shock Protein Upregulation.
The 70-kDa heat shock protein (Hsp70) as a therapeutic target for stroke.
The Association between Inflammatory Markers in the Acute Phase of Stroke and Long-Term Stroke Outcomes: Evidence from a Population-Based Study of Stroke.
The Broad Stroke of Hsp90 Inhibitors: Painting over the RAF Inhibitor Paradox.
The Effects of Mouse Recombinant Resistin on mRNA Expression of Proinflammatory and Anti-Inflammatory Cytokines and Heat Shock Protein-70 in Experimental Stroke Model.
The Hsp90 Inhibitor 17-DMAG Attenuates Hyperglycemia-Enhanced Hemorrhagic Transformation in Experimental Stroke.
The neuroprotective potential of heat shock protein 70 (HSP70).
The power stroke of the DnaK/DnaJ/GrpE molecular chaperone system.
The role of heat shock protein 70 in the protective effect of YC-1 on heat stroke rats.
The stress response: implications for the clinical development of hsp90 inhibitors.
[Distribution of 70kDa heat shock protein in rabbit brains after heat stress and heat stroke]
Strongyloidiasis
Structural and functional characterization of a novel scFv anti-HSP60 of Strongyloides sp.
Subarachnoid Hemorrhage
Heat shock protein 22 modulates NRF1/TFAM-dependent mitochondrial biogenesis and DRP1-sparked mitochondrial apoptosis through AMPK-PGC1? signaling pathway to alleviate the early brain injury of subarachnoid hemorrhage in rats.
Heat shock protein expression in cerebral vessels after subarachnoid hemorrhage.
Heat Shock Protein Expression in Cerebral Vessels after Subarachnoid Hemorrhage.
Inhibition of Heat Shock Protein 90 by 17-AAG Reduces Inflammation via P2X7 Receptor/NLRP3 Inflammasome Pathway and Increases Neurogenesis After Subarachnoid Hemorrhage in Mice.
Neuroprotective Effects of Valproic Acid on Blood-Brain Barrier Disruption and Apoptosis-Related Early Brain Injury in Rats Subjected to Subarachnoid Hemorrhage Are Modulated by Heat Shock Protein 70/Matrix Metalloproteinases and Heat Shock Protein 70/AKT Pathways.
Potential role for heat shock protein 72 in antagonizing cerebral vasospasm after rat subarachnoid hemorrhage.
Sudden Unexpected Death in Epilepsy
Sudden and unexpected death in epilepsy (SUDEP): evidence of acute neuronal injury using HSP-70 and c-Jun immunohistochemistry.
Sunburn
Increased expression of the 72-kDa heat shock protein and reduced sunburn cell formation in human skin after local hyperthermia.
Prevention of the ultraviolet effects on clinical and histopathological changes, as well as the heat shock protein-70 expression in mouse skin by topical application of algal UV-absorbing compounds.
Supranuclear Palsy, Progressive
The Small Heat Shock Protein HSP25/27 (HspB1) Is Abundant in Cultured Astrocytes and Associated with Astrocytic Pathology in Progressive Supranuclear Palsy and Corticobasal Degeneration.
Synovitis
A synthetic mycobacterial heat shock peptide prevents adjuvant arthritis but not proteoglycan-induced synovitis in the rat.
Chaperonin 60 regulation of SOX9 ubiquitination mitigates the development of knee osteoarthritis.
Synucleinopathies
Convergence of Heat Shock Protein 90 with Ubiquitin in Filamentous {alpha}-Synuclein Inclusions of {alpha}-Synucleinopathies.
Cytosolic Trapping of a Mitochondrial Heat Shock Protein Is an Early Pathological Event in Synucleinopathies.
Molecular chaperones and protein folding as therapeutic targets in Parkinson's disease and other synucleinopathies.
The HSP70 molecular chaperone is not beneficial in a mouse model of alpha-synucleinopathy.
Systemic Vasculitis
Human HSP 60 peptide responsive T cell lines are similarly present in both Behçet's disease patients and healthy controls.
Tachycardia
Exogenous heat shock cognate protein 70 pretreatment attenuates cardiac and hepatic dysfunction with associated anti-inflammatory responses in experimental septic shock.
HSPB1, HSPB6, HSPB7 and HSPB8 protect against RhoA GTPase-induced remodeling in tachypaced atrial myocytes.
Takayasu Arteritis
Cellular and humoral immune responses to mycobacterial heat shock protein-65 and its human homologue in Takayasu's arteritis.
Raised agalactosyl IgG and antimycobacterial humoral immunity in Takayasu's arteritis.
Reactivity of gamma/delta T cells to human 60-kd heat-shock protein and their cytotoxicity to aortic endothelial cells in Takayasu arteritis.
Takayasu's arteritis: role of Mycobacterium tuberculosis and its 65 kDa heat shock protein.
Tauopathies
Accelerated neurodegeneration through chaperone-mediated oligomerization of tau.
Decrease of neuronal FKBP4/FKBP52 modulates perinuclear lysosomal positioning and MAPT/Tau behavior during MAPT/Tau-induced proteotoxic stress.
Imbalance of Hsp70 family variants fosters tau accumulation.
Imbalances in the Hsp90 Chaperone Machinery: Implications for Tauopathies.
Intraneuronal accumulation of misfolded tau protein induces overexpression of Hsp27 in activated astrocytes.
Isoform-selective Genetic Inhibition of Constitutive Cytosolic Hsp70 Activity Promotes Client Tau Degradation Using an Altered Co-chaperone Complement.
Low endogenous and chemical induced heat shock protein induction in a 0N3Rtau-expressing Drosophila larval model of Alzheimer's disease.
Management of Hsp90-Dependent Protein Folding by Small Molecules Targeting the Aha1 Co-Chaperone.
Roles of heat-shock protein 90 in maintaining and facilitating the neurodegenerative phenotype in tauopathies.
Synthesis and Initial Evaluation of YM-08, a Blood-Brain Barrier Permeable Derivative of the Heat Shock Protein 70 (Hsp70) Inhibitor MKT-077, Which Reduces Tau Levels.
Tau phosphorylation, molecular chaperones, and ubiquitin E3 ligase: clinical relevance in Alzheimer's disease.
Tau Triage Decisions Mediated by the Chaperone Network.
The active Hsc70/tau complex can be exploited to enhance tau turnover without damaging microtubule dynamics.
The high-affinity HSP90-CHIP complex recognizes and selectively degrades phosphorylated tau client proteins.
The Hsp90 kinase co-chaperone Cdc37 regulates tau stability and phosphorylation dynamics.
TDP-43 Proteinopathies
Biology and Pathobiology of TDP-43 and Emergent Therapeutic Strategies.
Tendinopathy
Heat shock protein and apoptosis in supraspinatus tendinopathy.
Photobiomodulation therapy on expression of HSP70 protein and tissue repair in experimental acute Achilles tendinitis.
Teratocarcinoma
A binding site for the cyclic adenosine 3',5'-monophosphate-response element-binding protein as a regulatory element in the grp78 promoter.
ER Stress-Mediated Apoptotic Pathway Induced by Amyloid-beta.
Testicular Neoplasms
Stability of the Peutz-Jeghers syndrome kinase LKB1 requires its binding to the molecular chaperones Hsp90/Cdc37.
Testicular superoxide dismutase activity, heat shock protein 70 concentration and blood plasma inhibin-alpha concentration of dogs with a Sertoli cell tumor in a unilateral cryptorchid testis.
Tetanus
1alpha,25-dihydroxyvitamin D3 induces an autoantigen-specific T-helper 1/T-helper 2 immune shift in NOD mice immunized with GAD65 (p524-543).
Absence of peripheral blood T cell responses to "shared epitope' containing peptides in recent onset rheumatoid arthritis.
Comparison of cytokine ELISpot assay formats for the detection of islet antigen autoreactive T cells. Report of the third immunology of diabetes society T-cell workshop.
Depressed proliferative responses by peripheral blood mononuclear cells from early arthritis patients to mycobacterial heat shock protein 60.
Humoral response against heat shock proteins and other mycobacterial antigens after intravesical treatment with bacille Calmette-Guérin (BCG) in patients with superficial bladder cancer.
Immunological efficacy of heat shock protein 60 peptide DiaPep277 therapy in clinical type I diabetes.
Immunomodulatory effects of radiofrequency ablation in a breast cancer model.
Spinal fluid lymphocytes from a subgroup of multiple sclerosis patients respond to mycobacterial antigens.
Th1 and Th2 cell responses of type 1 diabetes patients and healthy controls to human heat-shock protein 60 peptides AA437-460 and AA394-408.
Tetralogy of Fallot
Expression of proto-oncogenes, genes for muscle specific isoforms and heat shock protein (HSP) -70 gene in hypertrophied cardiac muscles from patients with atrial septal defect or tetralogy of Fallot.
Heat shock protein 27 is increased in cyanotic tetralogy of Fallot myocardium and is associated with improved cardiac output and contraction.
Myocardial expression of heat shock protein 70i protects early postoperative right ventricular function in cyanotic tetralogy of Fallot.
Thalassemia
Increased Serum Heat Shock Protein 27 Antibody Titers and Prooxidant-Antioxidant Balance in Patients with Beta-Thalassemia Major.
Thrombocythemia, Essential
Mutant calreticulin knockin mice develop thrombocytosis and myelofibrosis without a stem cell self-renewal advantage.
The role of calreticulin mutations in myeloproliferative neoplasms.
Thrombocytopenia
Heat-shock protein gp96/grp94 is an essential chaperone for the platelet glycoprotein Ib-IX-V complex.
Platelet count correlates with stage and predicts survival in melanoma.
Thrombocytosis
Germ-line JAK2 mutations in the kinase domain are responsible for hereditary thrombocytosis and are resistant to JAK2 and HSP90 inhibitors.
HSP90 is a therapeutic target in JAK2-dependent myeloproliferative neoplasms in mice and humans.
Molecular pathogenesis of myelodysplastic syndromes with deletion 5q.
Thrombosis
Autoantibodies to heat shock protein 60 promote thrombus formation in a murine model of arterial thrombosis.
HSP90 promotes cell glycolysis, proliferation and inhibits apoptosis by regulating PKM2 abundance via Thr-328 phosphorylation in hepatocellular carcinoma.
Mechanism of collagen-induced release of 5-HT, PDGF-AB and sCD40L from human platelets: role of HSP27 phosphorylation via p44/p42 MAPK.
Regulation of tissue factor--mediated initiation of the coagulation cascade by cell surface grp78.
[Research Progress on Inflammasome and Cancer-associated Thrombosis-Review].
Thymoma
Heat shock protein 90-sheltered overexpression of insulin-like growth factor 1 receptor contributes to malignancy of thymic epithelial tumors.
LOXL1?AS1 promotes thymoma and thymic carcinoma progression by regulating miR?525?5p?HSPA9.
Matrin 3 co-immunoprecipitates with the heat shock proteins glucose-regulated protein 78 (GRP78), GRP75 and glutathione S-transferase ? isoform 2 (GST?2) in thymoma cells.
Thymus Neoplasms
Involvement of nonclassical MHC class Ib molecules in heat shock protein-mediated anti-tumor responses.
Thyroid Cancer, Papillary
Concomitant high expression of ER?36, GRP78 and GRP94 is associated with aggressive papillary thyroid cancer behavior.
Destabilizing RET in targeted treatment of thyroid cancers.
HIF-1? and HSP90: Target molecules selected from a tumorigenic papillary thyroid carcinoma cell line.
HSP90 inhibitor NVP-AUY922 induces cell apoptosis by disruption of the survivin in papillary thyroid carcinoma cells.
Mortalin (GRP75/HSPA9) Promotes Survival and Proliferation of Thyroid Carcinoma Cells.
The Relationship of Immunoexpression of Ki-67 and Hsp70 with Clinical and Morphological Parameters and Prognosis of Papillary Thyroid Cancer.
Thyroid Carcinoma, Anaplastic
17-Allylamino-17-demethoxygeldanamycin and Herbimycin A Induce Cell Death by Modulating ?-Catenin and PI3K/AKT Signaling in FRO Anaplastic Thyroid Carcinoma Cells.
Effect of mesoporous silica nanoparticles co?loading with 17?AAG and Torin2 on anaplastic thyroid carcinoma by targeting VEGFR2.
Herbimycin A inhibits cell growth with reversal of epithelial-mesenchymal transition in anaplastic thyroid carcinoma cells.
Hsp70 inhibition potentiates radicicol-induced cell death in anaplastic thyroid carcinoma cells.
Mortalin (GRP75/HSPA9) Promotes Survival and Proliferation of Thyroid Carcinoma Cells.
Novel Heat Shock Protein 90 Inhibitor NVP-AUY922 Synergizes With the Histone Deacetylase Inhibitor PXD101 in Induction of Death of Anaplastic Thyroid Carcinoma Cells.
Novel HSP90 inhibitors effectively target functions of thyroid cancer stem cell preventing migration and invasion.
The effect of 17-allylamino-17-demethoxygeldanamycin alone or in combination with paclitaxel on anaplastic thyroid carcinoma cells.
The heat shock protein 90 inhibitor SNX5422 has a synergistic activity with histone deacetylase inhibitors in induction of death of anaplastic thyroid carcinoma cells.
Thyroid Diseases
Analysis of heat shock protein polymorphisms in a large family with autoimmune thyroid diseases.
Anti 70 kDa heat shock protein antibodies in sera of patients affected by autoimmune and non-autoimmune thyroid diseases.
Detection of autoantibodies to the pancreatic islet heat shock protein 60 in insulin-dependent diabetes mellitus.
Immunohistochemical detection and localization of a 72-kilodalton heat shock protein in autoimmune thyroid disease.
Methimazole and propylthiouracil inhibit the oxygen free radical-induced expression of a 72 kilodalton heat shock protein in Graves' retroocular fibroblasts.
Thyroid Neoplasms
17-Allylamino-17-demethoxygeldanamycin activity against thyroid cancer cell lines correlates with heat shock protein 90 levels.
A novel heat shock protein inhibitor KU757 with efficacy in lenvatinib-resistant follicular thyroid cancer cells overcomes up-regulated glycolysis in drug-resistant cells in vitro.
A novel HSP90 modulator with selective activity against thyroid cancers in vitro.
Destabilizing RET in targeted treatment of thyroid cancers.
Different induction of GRP78 and CHOP as a predictor of sensitivity to proteasome inhibitors in thyroid cancer cells.
Efficacy of an HSP90 inhibitor, ganetespib, in preclinical thyroid cancer models.
Function of HSP90 and p23 in the telomerase complex of thyroid tumors.
Heat Shock Protein 90 Inhibitors AUY922, BIIB021 and SNX5422 Induce Bim-mediated Death of Thyroid Carcinoma Cells.
Heat shock proteins HSP90, HSP70 and GRP78 expression in medullary thyroid carcinoma.
IKK{gamma} protein is a target of BAG3 regulatory activity in human tumor growth.
Mortalin (GRP75/HSPA9) Promotes Survival and Proliferation of Thyroid Carcinoma Cells.
Mortalin (GRP75/HSPA9) upregulation promotes survival and proliferation of medullary thyroid carcinoma cells.
Novel HSP90 inhibitors effectively target functions of thyroid cancer stem cell preventing migration and invasion.
Nucleotide receptors stimulation by extracellular ATP controls Hsp90 expression through APE1/Ref-1 in thyroid cancer cells: a novel tumorigenic pathway.
Quercetin-Induced Cell Death in Human Papillary Thyroid Cancer (B-CPAP) Cells.
Synergistic cytotoxicity of BIIB021 with triptolide through suppression of PI3K/Akt/mTOR and NF-?B signal pathways in thyroid carcinoma cells.
The dipeptidyl peptidase-IV inhibitor gemigliptin alone or in combination with NVP-AUY922 has a cytotoxic activity in thyroid carcinoma cells.
The heat shock protein 90-binding geldanamycin inhibits cancer cell proliferation, down-regulates oncoproteins, and inhibits epidermal growth factor-induced invasion in thyroid cancer cell lines.
Tunicamycin promotes metastasis through upregulating endoplasmic reticulum stress induced GRP78 expression in thyroid carcinoma.
Thyroiditis
Data mining-based statistical analysis of biological data uncovers hidden significance: clustering Hashimoto's thyroiditis patients based on the response of their PBMC with IL-2 and IFN-? secretion to stimulation with Hsp60.
Elevated blood Hsp60, its structural similarities and cross-reactivity with thyroid molecules, and its presence on the plasma membrane of oncocytes point to the chaperonin as an immunopathogenic factor in Hashimoto's thyroiditis.
Induction in vitro of 72-kD heat shock protein in a continuous culture of rat thyroid cells, FRTL5.
Sequence homologies between hsp60 and autoantigens.
Tics
Cell surface GRP78 promotes stemness in normal and neoplastic cells.
Novel C-terminal heat shock protein 90 inhibitors target breast cancer stem cells and block migration, self-renewal, and epithelial-mesenchymal transition.
Suppression of Esophageal Cancer Stem-like Cells by SNX-2112 Is Enhanced by STAT3 Silencing.
Tinea
Heat Shock Protein 90 (Hsp90) as a Molecular Target for the Development of Novel Drugs Against the Dermatophyte Trichophyton rubrum.
Isolation and characterization of an immunogenic fragment of heat shock protein 60 from Trichophyton mentagrophytes.
Recombinant protein and DNA vaccines derived from hsp60 Trichophyton mentagrophytes control the clinical course of trichophytosis in bovine species and guinea-pigs.
Tinnitus
Western blot immunoassay for HSP-70 antibodies in idiopathic tinnitus: a preliminary report.
Tongue Neoplasms
Prognostic evaluation of p53, heat shock protein 70, Ki67, and CD34 expression in cancer of the tongue in Tunisia.
Tonsillitis
Relationship of endoplasmic reticulum stress with the etiopathogenesis of chronic tonsillitis and tonsillar hypertrophy in pediatric patients: a prospective, parallel-group study.
Tooth Diseases
Mitochondrial deficits and abnormal mitochondrial retrograde axonal transport play a role in the pathogenesis of mutant Hsp27-induced Charcot Marie Tooth Disease.
Tooth Loss
Tooth Loss Induces Memory Impairment and Gliosis in App Knock-In Mouse Models of Alzheimer's Disease.
Toxic Optic Neuropathy
A rat retinal damage model predicts for potential clinical visual disturbances induced by Hsp90 inhibitors.
Novel Tetrahydropyrido[4,3-d]pyrimidines as Potent Inhibitors of Chaperone Heat Shock Protein 90.
TAS-116, a highly selective inhibitor of heat shock protein 90? and ?, demonstrates potent antitumor activity and minimal ocular toxicity in preclinical models.
TAS-116, a Well-Tolerated Hsp90 Inhibitor, Prevents the Activation of the NLRP3 Inflammasome in Human Retinal Pigment Epithelial Cells.
Toxoplasmosis
Contribution of 65-kDa heat shock protein induced by gamma and delta T cells to protection against Toxoplasma gondii infection.
Immune Responses Induced by HSP60 DNA Vaccine against Toxoplasma gondii Infection in Kunming Mice.
Immunization with plasmid DNA expressing Heat Shock Protein 40 confers prophylactic protection against chronic Toxoplasma gondii infection in Kunming mice.
Induction of heat shock protein closely correlates with protection against Toxoplasma gondii infection.
Induction of protective immunity by DNA vaccination with Toxoplasma gondii HSP70, HSP30 and SAG1 genes.
Roles of NKT cells in resistance against infection with Toxoplasma gondii and in expression of heat shock protein 65 in the host macrophages.
Use of immunological methods to the detection of toxoplasmosis and heat shock protein HSP70 in men.
Tracheal Stenosis
Preproenkephalin gene expression in the rat cerebral cortex during chronic tracheal stenosis.
Trachoma
Characterization of humoral immune responses to chlamydial HSP60, CPAF, and CT795 in inflammatory and severe trachoma.
Immune response to chlamydial 60-kilodalton heat shock protein in tears from Nepali trachoma patients.
Multiple Chlamydiaceae species in trachoma: implications for disease pathogenesis and control.
Persistent Chlamydia trachomatis infections resist apoptotic stimuli.
Trauma, Nervous System
Differential neuroprotection from human heat shock protein 70 overexpression in in vitro and in vivo models of ischemia and ischemia-like conditions.
Heat Shock Protein 70 (HSP70) Induction: Chaperonotherapy for Neuroprotection after Brain Injury.
Hyperthermia assists survival of astrocytes from oxidative-mediated necrotic cell death.
Interaction of ethanol with inducers of glucose-regulated stress proteins. Ethanol potentiates inducers of grp78 transcription.
Tremor
Loss of Hsp70 exacerbates pathogenesis but not levels of fibrillar aggregates in a mouse model of Huntington's disease.
Triple Negative Breast Neoplasms
?B-crystallin: a novel regulator of breast cancer metastasis to the brain.
A novel chalcone-based molecule, BDP inhibits MDA?MB?231 triple-negative breast cancer cell growth by suppressing Hsp90 function.
C-terminal HSP90 inhibitor L80 elicits anti-metastatic effects in triple-negative breast cancer via STAT3 inhibition.
Chemotherapy Controls Metastasis Through Stimulatory Effects on GRP78 and Its Transcription Factor CREB3L1.
Chemotherapy Sensitizes Therapy-Resistant Cells to Mild Hyperthermia by Suppressing Heat Shock Protein 27 Expression in Triple-Negative Breast Cancer.
Erratum: The stabilization of PD-L1 by the endoplasmic reticulum stress protein GRP78 in triple-negative breast cancer.
Expression of glucose-regulated protein 78 as prognostic biomarkers for triple-negative breast cancer.
FOXP2 promotes tumor proliferation and metastasis by targeting GRP78 in triple-negative breast cancer.
Heat shock protein 90? inhibitor, PU-H71 in combination with DHEA promoting apoptosis in triple-negative breast cancer cell line MDA-MB-231.
HEXIM1 controls P-TEFb processing and regulates drug sensitivity in triple-negative breast cancer.
Hsp90 Inhibition Results in Glucocorticoid Receptor Degradation in Association with Increased Sensitivity to Paclitaxel in Triple-Negative Breast Cancer.
Hsp90 inhibitor PU-H71, a multimodal inhibitor of malignancy, induces complete responses in triple-negative breast cancer models.
Inhibition of HSP90 sensitizes a novel Raf/ERK dual inhibitor CY-9d in triple-negative breast cancer cells.
Investigation of B,C-ring truncated deguelin derivatives as heat shock protein 90 (HSP90) inhibitors for use as anti-breast cancer agents.
MicroPET/CT Imaging of AXL Downregulation by HSP90 Inhibition in Triple-Negative Breast Cancer.
Overcoming acquired resistance to HSP90 inhibition by targeting JAK-STAT signalling in triple-negative breast cancer.
Pharmacological induction of cell surface GRP78 contributes to apoptosis in triple negative breast cancer cells.
Preclinical activity profile and therapeutic efficacy of the HSP90 inhibitor ganetespib in triple-negative breast cancer.
Radiosynthesis, biological evaluation and preliminary microPET study of 18F-labeled 5-resorcinolic triazolone derivative based on ganetespib targeting HSP90.
Repositioning of Verrucosidin, a purported inhibitor of chaperone protein GRP78, as an inhibitor of mitochondrial electron transport chain complex I.
Simvastatin functions as a heat shock protein 90 inhibitor against triple-negative breast cancer.
The stabilization of PD-L1 by the endoplasmic reticulum stress protein GRP78 in triple-negative breast cancer.
Visualising dual downregulation of insulin-like growth factor receptor-1 and vascular endothelial growth factor-A by heat shock protein 90 inhibition effect in triple negative breast cancer.
Truncus Arteriosus, Persistent
Type 2 diabetes mellitus induces congenital heart defects in murine embryos by increasing oxidative stress, endoplasmic reticulum stress and apoptosis.
Trypanosomiasis
Heat shock protein 90 as a potential drug target against surra.
Post-transcriptional repair of a split heat shock protein 90 gene by mRNA trans-splicing.
Trypanosomiasis, African
Model System Identifies Kinetic Driver of Hsp90 Inhibitor Activity against African Trypanosomes and Plasmodium falciparum.
Overproduction, purification and characterisation of Tbj1, a novel Type III Hsp40 from Trypanosoma brucei, the African sleeping sickness parasite.
Protein phosphatase 5 is required for Hsp90 function during proteotoxic stresses in Trypanosoma brucei.
Tuberculosis
16 kDa heat shock protein from heat-inactivated Mycobacterium tuberculosis is a homodimer - suitability for diagnostic applications with specific llama VHH monoclonals.
A 71-kD heat shock protein (hsp) from Mycobacterium tuberculosis has modulatory effects on experimental rat arthritis.
A broad set of different llama antibodies specific for a 16 kDa heat shock protein of Mycobacterium tuberculosis.
A conserved mycobacterial heat shock protein (hsp) 70 sequence prevents adjuvant arthritis upon nasal administration and induces IL-10-producing T cells that cross-react with the mammalian self-hsp70 homologue.
A DNA vaccine against tuberculosis based on the 65 kDa heat-shock protein differentially activates human macrophages and dendritic cells.
A dominant human leucocyte antigen DR4-Dw15 restricted mycobacterial 65 kDa antigen-specific T-cell immunity in Chinese patients with rheumatoid arthritis.
A gene from Mycobacterium tuberculosis which is homologous to the DnaJ heat shock protein of E. coli.
A Humanized Monoclonal Antibody against Heat Shock Protein 60 Suppresses Murine Arthritis and Colitis and Skews the Cytokine Balance toward an Anti-Inflammatory Response.
A large fraction of human peripheral blood gamma/delta + T cells is activated by Mycobacterium tuberculosis but not by its 65-kD heat shock protein.
A Mycobacterium tuberculosis mutant lacking the groEL homologue cpn60.1 is viable but fails to induce an inflammatory response in animal models of infection.
A novel antigen-carrier system: the Mycobacterium tuberculosis Acr protein carried by raw starch microparticles.
A novel atherogenic epitope from Mycobacterium tuberculosis heat shock protein 65 enhances atherosclerosis in rabbit and LDL receptor-deficient mice.
A novel MtHSP70-FPR1 fusion protein enhances cytotoxic T lymphocyte responses to cervical cancer cells by activating human monocyte-derived dendritic cells via the p38 MAPK signaling pathway.
A novel mycobacterial Hsp70-containing fusion protein targeting mesothelin augments antitumor immunity and prolongs survival in murine models of ovarian cancer and mesothelioma.
A novel nucleoid-associated protein of Mycobacterium tuberculosis is a sequence homolog of GroEL.
A Novel Therapeutic and Prophylactic Vaccine (HVJ-Envelope / Hsp65 DNA + IL-12 DNA) against Tuberculosis Using the Cynomolgus Monkey Model.
A Novel Therapeutic and Prophylactic Vaccine against Tuberculosis Using the Cynomolgus Monkey Model and Mouse Model.
A peptide binding motif for I-Eg7, the MHC class II molecule that protects E alpha-transgenic nonobese diabetic mice from autoimmune diabetes.
A synthetic 10-kD heat shock protein (hsp10) from Mycobacterium tuberculosis modulates adjuvant arthritis.
A synthetic dengue virus antigen elicits enhanced antibody titers when linked to, but not mixed with, Mycobacterium tuberculosis HSP70 domain II.
A truncated C-terminal fragment of Mycobacterium tuberculosis HSP70 enhances cell-mediated immune response and longevity of the total IgG to influenza A virus M2e protein in mice.
Activation of T cells recognizing an epitope of heat-shock protein 70 can protect against rat adjuvant arthritis.
Activation of T cells recognizing self 60-kD heat shock protein can protect against experimental arthritis.
Age-associated changes in the proliferative response of rat intestinal intraepithelial leukocytes to bacterial antigens.
Alpha-crystallin promotes assembly of a trimeric form of Mycobacterium tuberculosis Hsp16.3 in a cell free system.
Anti-Hsp65 antibodies recognize M proteins of group A streptococci.
Antibodies against C-reactive protein cross-react with 60-kilodalton heat shock proteins.
Antibodies to mycobacterial 65 kDa heat shock protein in systemic sclerosis (scleroderma).
Antibody levels to mycobacteria in relation to HLA type: evidence for non-HLA-linked high levels of antibody to the 65 kD heat shock protein of M. bovis in rheumatoid arthritis.
Antibody to Mycobacterium tuberculosis 65 kDa heat shock protein in patients with rheumatoid arthritis--a survey of antigen-specific antibody isotypes and subclasses in an endemic area of previous tuberculosis infection.
Assays for adjuvanticity of new formulations and of carrier proteins for inducing antibody responses to selected immunogens in the squirrel monkey Saimiri sciureus.
Association between the 65-kilodalton heat shock protein, Streptococcus sanguis, and the corresponding antibodies in Behçet's syndrome.
Association of strong immune responses to PPE protein Rv1168c with active tuberculosis.
Autoantibodies to human heat shock protein (hsp)60 may be induced by Escherichia coli groEL.
Bacterial heat shock proteins directly induce cytokine mRNA and interleukin-1 secretion in macrophage cultures.
Bacterial luciferase is naturally destabilized in Mycobacterium tuberculosis and can be used to monitor changes in gene expression.
Bacterial thymidine kinase as a non-invasive imaging reporter for Mycobacterium tuberculosis in live animals.
BAG2 ameliorates endoplasmic reticulum stress-induced cell apoptosis in Mycobacterium tuberculosis-infected macrophages through selective autophagy.
Bb65, a major immunoreactive protein of Bartonella bacilliformis.
BCG and BCG/DNAhsp65 vaccinations promote protective effects without deleterious consequences for experimental autoimmune encephalomyelitis.
Biochemical characterization of ClpB protein from Mycobacterium tuberculosis and identification of its small-molecule inhibitors.
Biotechnology in the development of new vaccines and diagnostic reagents against tuberculosis.
Boosting with recombinant vaccinia increases HPV-16 E7-Specific T cell precursor frequencies and antitumor effects of HPV-16 E7-expressing Sindbis virus replicon particles.
C-terminal heat shock protein 70 of Mycobacterium tuberculosis as a molecular adjuvant for DNA vaccination with the porcine circovirus type 2 ORF2 (capsid) gene in mice.
Cell-mediated immune responses and protective efficacy against infection with Mycobacterium tuberculosis induced by Hsp65 and hIL-2 fusion protein in mice.
Change in kinetic regime of protein aggregation with temperature increase. Thermal aggregation of rabbit muscle creatine kinase.
Characterization of a 54-kDa heat-shock-inducible protein of Pasteurella haemolytica.
Characterization of a novel heat shock protein (Hsp22.5) involved in the pathogenesis of Mycobacterium tuberculosis.
Characterization of HPV-16 E6 DNA vaccines employing intracellular targeting and intercellular spreading strategies.
Characterization of prominent protein antigens from mycobacteria.
Chlamydial disease pathogenesis. The 57-kD chlamydial hypersensitivity antigen is a stress response protein.
Cloning and expression of malaria and tuberculosis epitopes in mycobacterium bovis bacille calmette-guérin.
Common antigens prediction in bacterial bioweapons: a perspective for vaccine design.
Comparative analysis of effects of cytokine gene adjuvants on DNA vaccination against Mycobacterium tuberculosis heat shock protein 65.
Comparison of HPV DNA vaccines employing intracellular targeting strategies.
Comparison of polymerase chain reaction amplification of two mycobacterial DNA sequences, IS6110 and the 65kDa antigen gene, in the diagnosis of tuberculosis.
Comparison of the CD8+ T cell responses and antitumor effects generated by DNA vaccine administered through gene gun, biojector, and syringe.
Comparison of the mucosal adjuvanticities of two Toll-like receptor ligands for recombinant adenovirus-delivered African swine fever virus fusion antigens.
Comprehensive gene expression profiling in lungs of mice infected with Mycobacterium tuberculosis following DNAhsp65 immunotherapy.
Construction and evaluation of luciferase reporter phages for the detection of active and non-replicating tubercle bacilli.
Construction, expression and identification of a recombinant BCG vaccine encoding human mycobacterium tuberculosis heat shock protein 65.
Contrasting evolutionary rates in the duplicate chaperonin genes of Mycobacterium tuberculosis and M. leprae.
Critical role of TRIF and MyD88 in Mycobacterium tuberculosis Hsp70-mediated activation of dendritic cells.
Cross-reactive B-cell epitopes of microbial and human heat shock protein 60/65 in atherosclerosis.
Cross-reactivity of anti-10kD heat shock protein antibodies in leprosy and tuberculosis patients.
Crystallization and preliminary X-ray crystallographic analysis of 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase from Mycobacterium tuberculosis.
Cytokine production and cytotoxicity mediated by CD4+ T cells from healthy subjects vaccinated with Mycobacterium bovis BCG and from pulmonary tuberculosis patients.
Dehydroepiandrosterone sulphate enhances IgG and Interferon-gamma production during immunization to tuberculosis in young but not aged mice.
Design and Construction of a Cloning Vector Containing the hspX Gene of Mycobacterium tuberculosis.
Detection of 65 kD heat shock protein in cerebrospinal fluid of tuberculous meningitis patients.
Detection of mycobacterial DNA in sarcoidosis and tuberculosis with polymerase chain reaction.
Determination of the sensitivity and specificity of PCR assays using different target dnas for the detection of Mycobacterium tuberculosis.
Diagnostic markers for tuberculosis ascites: a preliminary study.
Dietary restriction abrogates antibody production induced by a DNA vaccine encoding the mycobacterial 65 kDa heat shock protein.
Differential mycobacterial 65-kDa heat shock protein T cell epitope recognition after adjuvant arthritis-inducing or protective immunization protocols.
Differential regulation of Th1 and Th2 cells by p91-110 and p21-40 peptides of the 16-kD alpha-crystallin antigen of Mycobacterium tuberculosis.
Differentiation between Mycobacterium tuberculosis and Mycobacterium bovis by a multiplex-polymerase chain reaction.
Distribution of non-tuberculosis mycobacteria strains from suspected tuberculosis patients by heat shock protein 65 PCR-RFLP.
DNA amplification and reverse dot blot hybridization for detection and identification of mycobacteria to the species level in the clinical laboratory.
DNA vaccine containing the mycobacterial hsp65 gene prevented insulitis in MLD-STZ diabetes.
DNA vaccine using hemagglutinating virus of Japan-liposome encapsulating combination encoding mycobacterial heat shock protein 65 and interleukin-12 confers protection against Mycobacterium tuberculosis by T cell activation.
Dodecameric structure of the small heat shock protein Acr1 from Mycobacterium tuberculosis.
DR alpha: E beta heterodimers in DRA transgenic mice hinder expression of E alpha: E beta molecules and are more efficient in antigen presentation.
Dual-targeting GroEL/ES chaperonin and protein tyrosine phosphatase B (PtpB) inhibitors: A polypharmacology strategy for treating Mycobacterium tuberculosis infections.
Early appearing gamma/delta-bearing T cells during infection with Calmétte Guérin bacillus.
Effects of Mycobacterium tuberculosis Mutant Strain Hsp16.3 Gene on Murine RAW 264.7 Macrophage Autophagy.
Electrostatic interactions play a critical role in Mycobacterium tuberculosis Hsp16.3 binding of substrate proteins.
Enhanced immunity against hepatoma induced by dendritic cells pulsed with Hsp70-H22 peptide complexes and CD40L.
Enhanced protective efficacy against tuberculosis provided by a recombinant urease deficient BCG expressing heat shock protein 70-major membrane protein-II having PEST sequence.
Enhancement of DNA vaccine potency by coadministration of a tumor antigen gene and DNA encoding serine protease inhibitor-6.
Enhancement of DNA vaccine potency by linkage of antigen gene to an HSP70 gene.
Enhancement of Sindbis virus self-replicating RNA vaccine potency by linkage of Mycobacterium tuberculosis heat shock protein 70 gene to an antigen gene.
Enhancement of suicidal DNA vaccine potency by linking Mycobacterium tuberculosis heat shock protein 70 to an antigen.
Enhancement of tumor-specific T cell-mediated immunity in dendritic cell-based vaccines by Mycobacterium tuberculosis heat shock protein X.
Enhancing DNA vaccine potency by combining a strategy to prolong dendritic cell life with intracellular targeting strategies.
Evaluation of a novel vaccine (HVJ-liposome/HSP65 DNA+IL-12 DNA) against tuberculosis using the cynomolgus monkey model of TB.
Evaluation of heat shock proteins for discriminating between latent tuberculosis infection and active tuberculosis: A preliminary report.
Evaluation of highly conserved hsp65-specific nested PCR primers for diagnosing Mycobacterium tuberculosis.
Evaluation of the LiPA MYCOBACTERIA assay for identification of mycobacterial species from BACTEC 12B bottles.
Expression of foreign gene in mycobacterium regulated by human Mycobacterium tuberculosis heat shock protein 70 promoter.
Facilitated oligomerization of mycobacterial GroEL: evidence for phosphorylation-mediated oligomerization.
Functional analysis of DR17(DR3)-restricted mycobacterial T cell epitopes reveals DR17-binding motif and enables the design of allele-specific competitor peptides.
Functional insights by comparison of modeled structures of 18kDa small heat shock protein and its mutant in Mycobacterium leprae.
Functional similarities between the small heat shock proteins Mycobacterium tuberculosis HSP 16.3 and human alphaB-crystallin.
Fused Mycobacterium tuberculosis multi-stage immunogens with an Fc-delivery system as a promising approach for the development of a tuberculosis vaccine.
Fusion Molecules of Heat Shock Protein HSPX with Other Antigens of Mycobacterium tuberculosis Show High Potential in Serodiagnosis of Tuberculosis.
Gamma delta T cell receptor analysis supports a role for HSP 70 selection of lymphocytes in multiple sclerosis lesions.
Generation of a T cell receptor (TCR)-like single domain antibody (sDAb) against a Mycobacterium Tuberculosis (Mtb) heat shock protein (HSP) 16kDa antigen presented by Human Leukocyte Antigen (HLA)-A*02.
Genetic vaccine for tuberculosis (pVAXhsp65) primes neonate mice for a strong immune response at the adult stage.
Green fluorescent protein as a marker for gene expression and cell biology of mycobacterial interactions with macrophages.
GroEL2 of Mycobacterium tuberculosis Reveals the Importance of Structural Pliability in Chaperonin Function.
Heat shock protein X purified from Mycobacterium tuberculosis enhances the efficacy of dendritic cells-based immunotherapy for the treatment of allergic asthma.
Heat shock protein-induced T-lymphocyte propagation from endomyocardial biopsies in heart transplantation.
Heat shock proteins and antigens of Mycobacterium tuberculosis.
Helminth coinfection does not affect therapeutic effect of a DNA vaccine in mice harboring tuberculosis.
High-resolution melting curve analysis of heat shock protein 65 for identification of mycobacterial isolates.
Highly persistent and effective prime/boost regimens against tuberculosis that use a multivalent modified vaccine virus Ankara-based tuberculosis vaccine with interleukin-15 as a molecular adjuvant.
HLA-DR3 molecules can bind peptides carrying two alternative specific submotifs.
Homology of the 70-kilodalton antigens from Mycobacterium leprae and Mycobacterium bovis with the Mycobacterium tuberculosis 71-kilodalton antigen and with the conserved heat shock protein 70 of eucaryotes.
Hsp16.3 of mycobacterium tuberculosis in exosomes as a biomarker of tuberculosis.
HSP60, HSP70 in the pathogenesis of Kawasaki disease: implication and action.
Human immune response to Mycobacterium tuberculosis antigens.
Identification and characterization of protective T cells in hsp65 DNA-vaccinated and Mycobacterium tuberculosis-infected mice.
Identification of bis-ANS binding sites in Mycobacterium tuberculosis small heat shock protein Hsp16.3: Evidences for a two-step substrate-binding mechanism.
Identification of HLA class II-restricted determinants of Mycobacterium tuberculosis-derived proteins by using HLA-transgenic, class II-deficient mice.
Identification of nontuberculous mycobacterial infection by IS6110 and hsp65 gene analysis on lung tissues.
Identification of the monocyte activating motif in Mycobacterium tuberculosis chaperonin 60.1.
Immune modulation induced by tuberculosis DNA vaccine protects non-obese diabetic mice from diabetes progression.
Immune response induced by recombinant BCG expressing merozoite surface antigen 2 from Plasmodium falciparum.
Immunogenicity and protective efficacy of a DNA vaccine encoding the fusion protein of mycobacterium heat shock protein 65 (Hsp65) with human interleukin-2 against Mycobacterium tuberculosis in BALB/c mice.
Immunogenicity of a mycobacterial T-cell epitope expressed in outer membrane protein PhoE of Escherichia coli.
Immunological evaluation of a 12-kilodalton protein of Mycobacterium tuberculosis by enzyme-linked immunosorbent assay.
Immunomodulation and protection induced by DNA-hsp65 vaccination in an animal model of arthritis.
Immunotherapy of tuberculosis with Mycobacterium leprae Hsp65 as a DNA vaccine triggers cross-reactive antibodies against mammalian Hsp60 but not pathological autoimmunity.
Improved diagnosis of mycobacterial infections in formalin-fixed and paraffin-embedded sections with nested polymerase chain reaction.
Induction and therapy of autoimmune diabetes in the non-obese diabetic (NOD/Lt) mouse by a 65-kDa heat shock protein.
Induction of adjuvant arthritis in mice.
Induction of cellular immune reactions by A36, an antigen complex of Mycobacterium paratuberculosis: comparison of A36 and johnin components.
Influence of amino acids of a carrier protein flanking an inserted T cell determinant on T cell stimulation.
Introduction of 65 kDa antigen of Mycobacterium tuberculosis to cancer cells enhances anti-tumor effect of BCG therapy.
Is mycobacterial heat shock protein 16 kDa, a marker of the dormant stage of Mycobacterium tuberculosis, a sarcoid antigen?
Isolation and characterization of the groES and groEL genes of Bacillus subtilis Marburg.
Isolation, purification and preliminary X-ray characterization of Cpn60-2 (65 kDa heat-shock protein) from Mycobacterium tuberculosis.
Lack of protection in mice and necrotizing bronchointerstitial pneumonia with bronchiolitis in guinea pigs immunized with vaccines directed against the hsp60 molecule of Mycobacterium tuberculosis.
Legionella pneumophila htpAB heat shock operon: nucleotide sequence and expression of the 60-kilodalton antigen in L. pneumophila-infected HeLa cells.
Localisation of linear epitopes at the carboxy-terminal end of the mycobacterial 71 kDa heat shock protein.
Long-lasting specific antibodies against CETP induced by subcutaneous and mucosal administration of a 26-amino acid CETP epitope carried by heat shock protein 65 kDa in the absence of adjuvants.
Mannose-capped lipoarabinomannan- and prostaglandin E2-dependent expansion of regulatory T cells in human Mycobacterium tuberculosis infection.
Marked conservation of complementarity-determining region 3 of the beta-chain of TCRs recognizing a mycobacterial heat shock protein 60-derived peptide with strong sequence similarity to human heat shock protein 60.
Menstrual Blood versus Endometrial Biopsy in Detection of Genital Tuberculosis by Using Nested Polymerase Chain Reaction in an Endemic Region.
Modulation of adjuvant arthritis in Lewis rats by recombinant vaccinia virus expressing the human 60-kilodalton heat shock protein.
Modulatory effects of mycobacterial heat-shock protein 70 in DNA vaccination against lymphoma.
Molecular cloning and nucleotide sequence analysis of the gene encoding the immunoreactive Brucella abortus Hsp60 protein, BA60K.
Molecular cloning and sequencing of the circumsporozoite protein gene from Plasmodium falciparum strain FCC-1/HN and expression of the gene in Mycobacteria.
Molecular cloning and sequencing of the merozoite surface antigen 2 gene from Plasmodium falciparum strain FCC-1/HN and expression of the gene in mycobacteria.
MTBHsp70-exFPR1-pulsed Dendritic Cells Enhance the Immune Response against Cervical Cancer.
MtHsp70-CLIC1-pulsed dendritic cells enhance the immune response against ovarian cancer.
Multiple gene duplication and rapid evolution in the groEL gene: functional implications.
Murine and human B cell epitope mapping of the Mycobacterium tuberculosis 10-kD heat shock protein using overlapping peptides.
Mutational analysis of the mycobacteriophage BPs promoter PR reveals context-dependent sequences for mycobacterial gene expression.
Mycobacteria and human autoimmune disease: direct evidence of cross-reactivity between human lactoferrin and the 65-kilodalton protein of tubercle and leprosy bacilli.
Mycobacterial heat shock protein 65 mediated metabolic shift in decidualization of human endometrial stromal cells.
Mycobacterial Hsp65 antigen upregulates the cellular immune response of healthy individuals compared with tuberculosis patients.
Mycobacterium leprae-specific T cells from a tuberculoid leprosy patient suppress HLA-DR3-restricted T cell responses to an immunodominant epitope on 65-kDa hsp of mycobacteria.
Mycobacterium tuberculosis chaperonin 60.1 is a more potent cytokine stimulator than chaperonin 60.2 (Hsp 65) and contains a CD14-binding domain.
Mycobacterium tuberculosis ClpC1: characterization and role of the N-terminal domain in its function.
Mycobacterium tuberculosis complex in atherosclerosis.
Mycobacterium tuberculosis Cpn60.2 (GroEL2) blocks macrophage apoptosis via interaction with mitochondrial mortalin.
Mycobacterium tuberculosis employs Cpn60.2 as an adhesin that binds CD43 on the macrophage surface.
Mycobacterium tuberculosis GroEL homologues unusually exist as lower oligomers and retain the ability to suppress aggregation of substrate proteins.
Mycobacterium tuberculosis heat-shock protein 70 impairs maturation of dendritic cells from bone marrow precursors, induces interleukin-10 production and inhibits T-cell proliferation in vitro.
Mycobacterium tuberculosis Hsp16.3 nonamers are assembled and re-assembled via trimer and hexamer intermediates.
Mycobacterium tuberculosis Rv0991c Is a Redox-Regulated Molecular Chaperone.
Natural antibodies to 65 kD mycobacterial heat shock protein in rats do not correlate with susceptibility for Mycobacterium tuberculosis induced adjuvant arthritis.
New alternative vaccine component against mycobacterium tuberculosis--heat shock protein 16.3 or its T-cell epitope.
No evidence for serological autoimmunity to islet cell heat shock proteins in insulin dependent diabetes.
Novel prophylactic and therapeutic vaccine against tuberculosis.
Novel recombinant BCG and DNA-vaccination against tuberculosis in a cynomolgus monkey model.
Novel selection for isoniazid (INH) resistance genes supports a role for NAD+-binding proteins in mycobacterial INH resistance.
Novel vaccines for the treatment of chronic HBV infection based on mycobacterial heat shock protein 70.
Optimisation of human VH domain antibodies specific to Mycobacterium tuberculosis heat shock protein (HSP16.3).
Outer membrane protein PhoE as a carrier for the exposure of foreign antigenic determinants at the bacterial cell surface.
Over-expression of gene encoding heat shock protein 70 from Mycobacterium tuberculosis and its evaluation as vaccine adjuvant.
Overexpression of DosR in Mycobacterium tuberculosis does not affect aerobic replication in vitro or in murine macrophages
Overexpression of the celA1 gene in BCG modifies surface pellicle, glucosamine content in biofilms, and affects in vivo replication.
Peptide 19 of Porphyromonas gingivalis Heat Shock Protein Is a Potent Inducer of Low-Density Lipoprotein Oxidation.
Peptide-induced nasal tolerance for a mycobacterial heat shock protein 60 T cell epitope in rats suppresses both adjuvant arthritis and nonmicrobially induced experimental arthritis.
Physiological consequences associated with overproduction of Mycobacterium tuberculosis FtsZ in mycobacterial hosts.
Porphyromonas gingivalis lipopolysaccharide antagonizes Escherichia coli lipopolysaccharide at toll-like receptor 4 in human endothelial cells.
Predominant immunoreactivity of Porphyromonas gingivalis heat shock protein in autoimmune diseases.
Preferential binding with Escherichia coli hsp60 of antibodies prevalent in sera from patients with rheumatoid arthritis.
Preheat treatment for Mycobacterium tuberculosis Hsp16.3: correlation between a structural phase change at 60 degrees C and a dramatic increase in chaperone-like activity.
Preventive administration of Mycobacterium tuberculosis 10-kDa heat shock protein (hsp10) suppresses adjuvant arthritis in Lewis rats.
Probing the roles of the only universally conserved leucine residue (Leu122) in the oligomerization and chaperone-like activity of Mycobacterium tuberculosis small heat shock protein Hsp16.3.
Prophylactic, therapeutic and anti-metastatic effects of an HPV-16mE6Delta/mE7/TBhsp70Delta fusion protein vaccine in an animal model.
Protective efficacy of a DNA vaccine construct encoding the VP2 gene of infectious bursal disease and a truncated HSP70 of Mycobacterium tuberculosis in chickens.
Pulmonary necrosis resulting from DNA vaccination against tuberculosis.
Raised agalactosyl IgG and antimycobacterial humoral immunity in Takayasu's arteritis.
Raw starch microparticles have immunostimulant activity in mice vaccinated with BCG and challenged with Mycobacterium tuberculosis.
Reconstituted complexes of mycobacterial HSP70 and EBV LMP2A-derived peptides elicit peptide-specific cytotoxic T lymphocyte responses and anti-tumor immunity.
Regulation of the alpha-crystallin gene acr2 by the MprAB two-component system of Mycobacterium tuberculosis.
Requisite role for interleukin-4 in the acceleration of fatty streaks induced by heat shock protein 65 or Mycobacterium tuberculosis.
Reversible methionine sulfoxidation of Mycobacterium tuberculosis small heat shock protein Hsp16.3 and its possible role in scavenging oxidants.
Robust immunoreactivity of teenager sera against peptide 19 from Porphyromonas gingivalis HSP60.
Serodiagnosis of tuberculosis based on the analysis of the 65 kD heat shock protein of Mycobacterium tuberculosis.
Serum antibodies from patients with ankylosing spondylitis and Reiter's syndrome are reactive with HLA-B27 cells transfected with the Mycobacterium tuberculosis hsp60 gene.
Site-directed mutation on the only universally conserved residue Leu122 of small heat shock protein Hsp16.3.
Spinal fluid lymphocytes from a subgroup of multiple sclerosis patients respond to mycobacterial antigens.
Structural and functional conservation of Mycobacterium tuberculosis GroEL paralogs suggests that GroEL1 Is a chaperonin.
Superior adjuvanticity of the genetically fused D1 domain of Neisseria meningitides Ag473 lipoprotein among three Toll-like receptor ligands.
Suppression of adjuvant arthritis in rats by induction of oral tolerance to mycobacterial 65-kDa heat shock protein.
Synergistic effect of muramyl dipeptide with heat shock protein 70 from Mycobacterium tuberculosis on immune activation.
Synthesis of heat shock proteins in Thermoanaerobacterium thermosulfurigenes EM1 (Clostridium thermosulfurogenes EM1).
Synthetic peptides non-covalently bound to bacterial hsp 70 elicit peptide-specific T-cell responses in vivo.
T cell epitope expression of mycobacterial and homologous human 65-kilodalton heat shock protein peptides in short term cell lines from patients with Behçet's disease.
T cells in the lesion of experimental autoimmune encephalomyelitis. Enrichment for reactivities to myelin basic protein and to heat shock proteins.
T-cell recognition of mycobacterial GroES peptides in Thai leprosy patients and contacts.
TAC from Mycobacterium tuberculosis: a paradigm for stress-responsive toxin-antitoxin systems controlled by SecB-like chaperones.
Takayasu's arteritis: role of Mycobacterium tuberculosis and its 65 kDa heat shock protein.
Targeted detection of 65 kDa heat shock protein gene in endometrial biopsies for reliable diagnosis of genital tuberculosis.
Targeted induction of antigen expression within dendritic cells modulates antigen-specific immunity afforded by recombinant BCG.
TCR-like domain antibody against Mycobacterium tuberculosis (Mtb) heat shock protein antigen presented by HLA-A*11 and HLA-A*24.
Temperature-dependent subunit exchange and chaperone-like activities of Hsp16.3, a small heat shock protein from Mycobacterium tuberculosis.
Th1 polarized response induced by intramuscular DNA-HSP65 immunization is preserved in experimental atherosclerosis.
The 'tubulin-like' S1 protein of Spirochaeta is a member of the hsp65 stress protein family.
The adjuvant effects of Mycobacterium tuberculosis heat shock protein 70 result from the rapid and prolonged activation of antigen-specific CD8+ T cells in vivo.
The association of small heat shock protein Hsp16.3 with the plasma membrane of Mycobacterium tuberculosis: dissociation of oligomers is a prerequisite.
The construction of Schistosoma japonicum vaccine BCG-Sj26GST and its identification.
The heat shock response of mycobacterium tuberculosis: linking gene expression, immunology and pathogenesis.
The humoral response in TCR alpha-/- mice. Can gammadelta-T cells support the humoral immune response?
The immune response to mycobacterial 70-kDa heat shock proteins frequently involves autoreactive T cells and is quantitatively disregulated in multiple sclerosis.
The impact of different mutations at arginine141 on the structure, subunit exchange dynamics and chaperone activity of Hsp16.3.
The impact of DR3 microvariation on peptide binding: the combinations of specific DR beta residues critical to binding differ for different peptides.
The mycobacterial GroEL stress protein: a common target of T-cell recognition in infection and autoimmunity.
The Mycobacterium tuberculosis 65-kilodalton antigen is a heat shock protein which corresponds to common antigen and to the Escherichia coli GroEL protein.
The Mycobacterium tuberculosis small heat shock protein Hsp16.3 exposes hydrophobic surfaces at mild conditions: conformational flexibility and molecular chaperone activity.
The potent bone-resorbing mediator of Actinobacillus actinomycetemcomitans is homologous to the molecular chaperone GroEL.
The recombinant 65-kD heat shock protein of Mycobacterium bovis Bacillus Calmette-Guerin/M. tuberculosis is a target molecule for CD4+ cytotoxic T lymphocytes that lyse human monocytes.
Therapeutic efficacy of a tuberculosis DNA vaccine encoding heat shock protein 65 of Mycobacterium tuberculosis and the human interleukin 2 fusion gene.
Treatment of adjuvant arthritis with granulocyte-colony stimulating factor and peptide derived from heat shock protein 65.
Use of restriction enzyme analysis of amplified DNA coding for the hsp65 gene and polymerase chain reaction with universal primer for rapid differentiation of mycobacterium species in the clinical laboratory.
Vaccination against tuberculosis by DNA injection.
Vaccine adjuvant: it makes the difference.
VaxCelerate II: rapid development of a self-assembling vaccine for Lassa fever.
Virulence, immunogenicity, and protective efficacy of two recombinant Mycobacterium bovis bacillus Calmette-Guérin strains expressing the antigen ESAT-6 from Mycobacterium tuberculosis.
[Amplification of 2 different gene segments of Mycobacterium tuberculosis and its usefulness in the diagnosis of tuberculosis]
[Anti-tuberculosis immunity by cytotoxic T cells * granulysin and the development of novel vaccines (HSP-65 DNA+IL-12 DNA)]
[Cloning and prokaryotic expression of heat shock protein 70 gene of Mycobacterium tuberculosis]
[Construction of a secreting prokaryotic shuttle expressing plasmid pBCG-sP-HSP65 and its expression in Mycobacterial smegmatis]
[Construction of fusion gene vaccine of WT1 multi-epitope fused with stimulating epitope of mycobacterium tuberculosis heat shock protein 70 and its expression and immunogenicity].
[Construction of recombinant Mycobacterium smegmatis expressing ESAT-6 and its effects on macrophages]
[Construction of replication-deficient recombinant adenoviral vector carrying HBsAg and HSP70 chimeric gene and its expression in vitro]
[Construction of the eukaryotic coexpression vector containing Mycobacterium tuberculosis heat shock protein 70 and green fluorescent protein.]
[Heat-shock protein enhances immunogenicity of E7 oncoprotein of human papillomavirus included in chimeric construction (E7 HPV-HSP70)].
[Histological and immunohistochemical structure of pulmonary tuberculotic granulomas in untreated cases and cases treated with antitubercular drugs]
[Immune adjuvant effect of TB.HSP70 to its accompanying cytotoxic T lymphocytes epitope elicits HBV specific immune response]
[Immunocontraceptive effect of DNA vaccines of Lagurus lagurus zona pellucida 3 fusioned with C-terminal of HSP70.]
[Immunogenic Mycobacterium tuberculosis heat shock protein in tuberculosis]
[Improved efficacy of P277 fused to heat shock protein 65 of Mycobacterium tuberculosis against diabetes in nonobese diabetic mice]
[Intranasal vaccination with mycobacterial 65-kD heat-shock protein can prevent insulitis and diabetes in non-obese diabetic mice].
[Intratumor injection of recombinant attenuated salmonella carrying Mycobacterium tuberculosis heat shock protein 70 and herpes simplex virus thymidine kinase genes to suppress murine melanoma growth].
[Novel vaccines against M. tuberculosis]
[Participation of gamma/delta-T cells in the protection against mycobacterial infection]
[Participation of heat shock proteins in modulation of NF-?B transcription factor activation during bacterial infections].
[Prokaryotic expression and function detection of Mycobacterium tuberculosis Hsp16.3].
[Proteomic analysis of U937 cells expressing Mycobacterium tuberculosis heat shock protein 16.3].
[Rapid detection and identification of mycobacteria by the PCR assay based on the co-amplification of the gene IS6110 and groEL]
[Role of molecular adjuvants TBhsp and MT in the preparation of monoclonal antibody against phosphatase of regenerating liver-3].
[Secretion expression of Mt. heat shock protein 70 in Pichia pastoris and identification of the protein]
[Study of HSP70 gene upstream regulation element on expression efficiency of GST gene in M. smegmatis]
[The development of novel vaccines against tuberculosis]
[The immunological responses induced by Mycobacterium tuberculosis heat shock protein 16.3 and its synthetic peptide in mice]
Tuberculosis, Bovine
Heat shock protein 70 subunit vaccination against bovine paratuberculosis does not interfere with current immunodiagnostic assays for bovine tuberculosis.
Tuberculosis, Meningeal
Detection of 65 kD heat shock protein in cerebrospinal fluid of tuberculous meningitis patients.
Polymerase chain reaction, with sequencing, as a diagnostic tool in culture---negative bacterial meningitis.
Tuberculosis, Pulmonary
Polymorphism in heat-shock protein 70-1 (HSP70-1) gene promoter region and susceptibility to tuberculoid leprosy and pulmonary tuberculosis in Asian Indians.
Tuberous Sclerosis
MTORC1 coordinates the autophagy and apoptosis signaling in articular chondrocytes in osteoarthritic temporomandibular joint.
Mutation of the co-chaperone Tsc1 in bladder cancer diminishes Hsp90 acetylation and reduces drug sensitivity and selectivity.
The Role of Heat Shock Protein-90 in the Pathogenesis of Birt-Hogg-Dubé and Tuberous Sclerosis Complex Syndromes.
Tuberous sclerosis complex protein 1 expression is affected by VHL Gene alterations and HIF-1? production in sporadic clear-cell renal cell carcinoma.
Tularemia
B-cell epitopes in GroEL of Francisella tularensis.
type i protein arginine methyltransferase deficiency
PRMT6 deficiency induces autophagy in hostile microenvironments of hepatocellular carcinoma tumors by regulating BAG5-associated HSC70 stability.
Typhoid Fever
Effect of adjuvants on immune response and protective immunity elicited by recombinant Hsp60 (GroEL) of Salmonella typhi against S. typhi infection.
Immunogenic epitopes of Salmonella typhi GroEL heat shock protein reactive with both monoclonal antibody and patients sera.
Typhus, Endemic Flea-Borne
Molecular epidemic survey on co-prevalence of scrub typhus and marine typhus in Yuxi city, Yunnan province of China.
Typhus, Epidemic Louse-Borne
Molecular cloning and sequence analysis of the Sta58 major antigen gene of Rickettsia tsutsugamushi: sequence homology and antigenic comparison of Sta58 to the 60-kilodalton family of stress proteins.
Molecular detection and groEL typing of Rickettsia aeschlimannii in Sardinian ticks.
Molecular epidemic survey on co-prevalence of scrub typhus and marine typhus in Yuxi city, Yunnan province of China.
Uremia
Obstruction of proximal tubules initiates cytoresistance against hypoxic damage.
Resveratrol Reduces Kidney Injury in a Rat Model of Uremia and is Associated with Increased Expression of Heat Shock Protein 70 (Hsp70).
Ureteral Obstruction
Activation of AMP-activated protein kinase inhibits ER stress and renal fibrosis.
Effect of laminarin on the expression of GRP78 and GRP94 in rat after unilateral ureteral obstruction.
Heat shock protein 90 inhibitor attenuates renal fibrosis through degradation of transforming growth factor-? type II receptor.
Increased heat shock protein-70 in unilateral ureteral obstruction in rats.
The Nrf2-Keap1 cellular defense pathway and heat shock protein 70 (Hsp70) response. Role in protection against oxidative stress in early neonatal unilateral ureteral obstruction (UUO).
Wt-1 Expression Linked to Nitric Oxide Availability during Neonatal Obstructive Nephropathy.
Urethral Obstruction
Increased expression of heat shock protein 20 and decreased contractile stress in obstructed rat bladder.
Urethritis
Antibodies to Chlamydia trachomatis heat-shock protein 60 kDa and detection of Mycoplasma genitalium and ureaplasma urealyticum are associated independently with chronic nongonococcal urethritis.
Association of antibodies to Chlamydia trachomatis heat-shock protein 60 kD with chronic nongonococcal urethritis.
Urinary Bladder Neck Obstruction
Increased expression of heat shock protein 20 and decreased contractile stress in obstructed rat bladder.
Urinary Bladder Neoplasms
17-Allylamino-17-demethoxygeldanamycin induces downregulation of critical Hsp90 protein clients and results in cell cycle arrest and apoptosis of human urinary bladder cancer cells.
17-DMAG induces heat shock protein 90 functional impairment in human bladder cancer cells: knocking down the hallmark traits of malignancy.
Clinical significance of heat shock protein-70 expression in bladder cancer.
Clinical, prognostic, and therapeutic significance of heat shock protein 27 in bladder cancer.
Combined inhibition of heat shock proteins 90 and 70 leads to simultaneous degradation of the oncogenic signaling proteins involved in muscle invasive bladder cancer.
Discovering Therapeutic Protein Targets for Bladder Cancer Using Proteomic Data Analysis
Dual targeting of heat shock proteins 90 and 70 promotes cell death and enhances the anticancer effect of chemotherapeutic agents in bladder cancer.
Dysregulated genes targeted by microRNAs and metabolic pathways in bladder cancer revealed by bioinformatics methods.
Enhanced sensitivity to mitomycin C by abating heat shock protein 70 expression in human bladder cancer cell line of BIU-87.
FGFR3 translocations in bladder cancer: differential sensitivity to HSP90 inhibition based on drug metabolism.
Fucoxanthin induces growth arrest and apoptosis in human bladder cancer T24 cells by up-regulation of p21 and down-regulation of mortalin.
Heat shock protein expression in testis and bladder cancer cell lines exhibiting differential sensitivity to heat.
Heat shock protein expression independently predicts survival outcome in schistosomiasis-associated urinary bladder cancer.
Heat shock protein-90, IL-6 and IL-10 in bladder cancer.
Heat shock proteins 60 and 70 are associated with long-term outcome of T1-stage high-grade urothelial tumors of the bladder treated with intravesical Bacillus Calmette-Guérin immunotherapy.
Heat-shock protein 70-2 (HSP70-2) expression in bladder urothelial carcinoma is associated with tumour progression and promotes migration and invasion.
High expression of heat shock protein 105 predicts a favorable prognosis for patients with urinary bladder cancer treated with radical cystectomy.
HSP60 may predict good pathological response to neoadjuvant chemoradiotherapy in bladder cancer.
HSP90 expression: a new predictive factor for BCG response in stage Ta-T1 grade 3 bladder tumours.
Humoral response against heat shock proteins and other mycobacterial antigens after intravesical treatment with bacille Calmette-Guérin (BCG) in patients with superficial bladder cancer.
Image-guided photo-therapeutic nanoporphyrin synergized HSP90 inhibitor in patient-derived xenograft bladder cancer model.
Immunohistochemical detection of the 150-kDa oxygen-regulated protein in bladder cancer.
Inhibition of inducible heat shock protein-70 (hsp72) enhances bortezomib-induced cell death in human bladder cancer cells.
Lens epithelium-derived growth factor is an Hsp70-2 regulated guardian of lysosomal stability in human cancer.
Low dose geldanamycin inhibits hepatocyte growth factor and hypoxia-stimulated invasion of cancer cells.
Low-dose Hsp90 inhibitors tumor-selectively sensitize bladder cancer cells to chemoradiotherapy.
miR-30d, miR-181a and miR-199a-5p cooperatively suppress the endoplasmic reticulum chaperone and signaling regulator GRP78 in cancer.
Mutation of the co-chaperone Tsc1 in bladder cancer diminishes Hsp90 acetylation and reduces drug sensitivity and selectivity.
p63? protein up-regulates heat shock protein 70 expression via E2F1 transcription factor 1, promoting Wasf3/Wave3/MMP9 signaling and bladder cancer invasion.
Potential role of Hsp90 inhibitors in overcoming cisplatin resistance of bladder cancer-initiating cells.
Proteomic analysis of proteome and histone post-translational modifications in heat shock protein 90 inhibition-mediated bladder cancer therapeutics.
Small interfering RNA targeting heat shock protein 70 enhances chemosensitivity in human bladder cancer cells.
Synergistic Antitumor Effects of Combined Treatment with HSP90 Inhibitor and PI3K/mTOR Dual Inhibitor in Cisplatin-Resistant Human Bladder Cancer Cells.
Targeted inhibition of heat shock protein 90 disrupts multiple oncogenic signaling pathways, thus inducing cell cycle arrest and programmed cell death in human urinary bladder cancer cell lines.
Targeting Hsp90 in urothelial carcinoma.
The effect of heat shock protein 90 inhibitors on histone 4 lysine 20 methylation in bladder cancer.
[The heat shock protein 70 antisense oligomers enhance the sensitivity of bladder cancer cell EJ to mitomycin C]
Urinary Tract Infections
Heat shock protein 72 (HSPA1B) gene polymorphism and Toll-like receptor (TLR) 4 mutation are associated with increased risk of urinary tract infection in children.
The curli biogenesis genes expression level is unassociated with Enterobacter cloacae hsp60 clusters and PFGE genotypes.
Urine heat shock protein 70 levels as a marker of urinary tract infection in children.
Urologic Neoplasms
Heat shock proteins: their role in urological tumors.
Mechanisms of disease: the role of heat-shock protein 90 in genitourinary malignancy.
Urticaria
Elevated circulating heat shock protein 70 and its antibody concentrations in chronic spontaneous urticaria.
Uterine Cervical Neoplasms
A novel MtHSP70-FPR1 fusion protein enhances cytotoxic T lymphocyte responses to cervical cancer cells by activating human monocyte-derived dendritic cells via the p38 MAPK signaling pathway.
Are IgG antibodies to heat shock proteins HSP27 and HSP60 useful markers in endometrial cancer and cervical cancer?
Assessment of hypoxia inducible factor levels in cancer cell lines upon hypoxic induction using a novel reporter construct.
Boosting the effects of hyperthermia-based anticancer treatments by HSP90 inhibition.
Bortezomib Targets the Caspase-Like Proteasome Activity in Cervical Cancer Cells, Triggering Apoptosis That Can be Enhanced by Nelfinavir.
CD4+ T cell-mediated antigen-specific immunotherapy in a mouse model of cervical cancer.
Correction: Soluble B and T Lymphocyte Attenuator Possesses Antitumor Effects and Facilitates Heat Shock Protein 70 Vaccine-Triggered Antitumor Immunity against a Murine TC-1 Cervical Cancer Model In Vivo.
Diagnostic value of heat shock protein 90? and squamous cell carcinoma antigen in detection of cervical cancer.
E6^E7, a novel splice isoform protein of human papillomavirus 16, stabilizes viral E6 and E7 oncoproteins via HSP90 and GRP78.
Effect of a heat shock protein 90-specific inhibitor on the proliferation and apoptosis induced by VEGF-C in cervical cancer cells.
Effects of retinoic acid on the expression of a tumor rejection antigen (heat shock protein gp96) in human cervical cancer.
Endoplasmic reticulum stress as a correlate of cytotoxicity in human tumor cells exposed to diindolylmethane in vitro.
Enhancement of Radiation Effectiveness in Cervical Cancer Cells by Combining Ionizing Radiation with Hyperthermia and Molecular Targeting Agents.
Evaluation of short- and long-term efficacy of chemoradiotherapy for advanced cervical cancer using HSP70 protein combined with multimodal MRI.
Expression of heat shock protein 60 kDa is upregulated in cervical cancer.
Germ cell-specific heat shock protein 70-2 is expressed in cervical carcinoma and is involved in the growth, migration, and invasion of cervical cells.
Glucose-Related Protein 78 Expression and Its Effects on Cisplatin-Resistance in Cervical Cancer.
Heat shock protein 90 inhibitor mycoepoxydiene modulates kinase signaling in cervical cancer cells and inhibits in-vivo tumor growth.
Hsp90 Inhibitor SNX-2112 Enhances TRAIL-Induced Apoptosis of Human Cervical Cancer Cells via the ROS-Mediated JNK-p53-Autophagy-DR5 Pathway.
Human papillomavirus E6: Host cell receptor, GRP78, binding site prediction.
LINC00294 induced by GRP78 promotes cervical cancer development by promoting cell cycle transition.
MicroRNA-361-Mediated Inhibition of HSP90 Expression and EMT in Cervical Cancer Is Counteracted by Oncogenic lncRNA NEAT1.
MicroRNA216b mediated downregulation of HSP27/STAT3/AKT signaling is critically involved in lambertianic acid induced apoptosis in human cervical cancers.
MiR-181a Inhibits Cervical Cancer Development Via Downregulating GRP78.
MTBHsp70-exFPR1-pulsed Dendritic Cells Enhance the Immune Response against Cervical Cancer.
Novel immunohistochemical monoclonal antibody against human glucose-regulated protein 78.
Proteomic analysis of cancer tissues: shedding light on carcinogenesis and possible biomarkers.
Recombinant adeno-associated virus expressing human papillomavirus type 16 E7 peptide DNA fused with heat shock protein DNA as a potential vaccine for cervical cancer.
Recombinant heat shock protein 27 (HSP27/HSPB1) protects against cadmium-induced oxidative stress and toxicity in human cervical cancer cells.
Repercussion of Mitochondria Deformity Induced by Anti-Hsp90 Drug 17AAG in Human Tumor Cells.
Serum antibody response to the heat shock protein 60 of Chlamydia trachomatis in women with developing cervical cancer.
Soluble B and T lymphocyte attenuator possesses antitumor effects and facilitates heat shock protein 70 vaccine-triggered antitumor immunity against a murine TC-1 cervical cancer model in vivo.
Stressing the ubiquitin-proteasome system without 20S proteolytic inhibition selectively kills cervical cancer cells.
Synergistic activity of Hsp90 inhibitors and anticancer agents in pancreatic cancer cell cultures.
Targeting focal adhesion kinase with dominant-negative FRNK or Hsp90 inhibitor 17-DMAG suppresses tumor growth and metastasis of SiHa cervical xenografts.
The effects of irradiation on the expression of a tumour rejection antigen (heat shock protein gp96) in human cervical cancer.
Ubiquitin ligase CHIP regulates OTUD3 stability and suppresses tumour metastasis in lung cancer.
Ultrasound irradiation inhibits proliferation of cervical cancer cells by initiating endoplasmic reticulum stress-mediated apoptosis and triggering phosphorylation of JNK.
[Expressions of heat shock protein in cervical cancer and precancerosis].
[Therapeutic effects of B and T lymphocyte attenuator extracellular domain and heat shock protein 70 antigen peptide on cervical cancer in mouse model.]
Uterine Neoplasms
Paclitaxel inhibits expression of heat shock protein 27 in ovarian and uterine cancer cells.
Uveitis
Administration of Mycobacterium leprae rHsp65 aggravates experimental autoimmune uveitis in mice.
Association between heat shock protein 70/Hom genetic polymorphisms and uveitis in patients with sarcoidosis.
Circulating antibodies to inducible heat shock protein 70 in patients with uveitis.
Common antigenicity between Yersinia enterocolitica-derived heat-shock protein and the retina, and its role in uveitis.
Cytokine, C-Reactive Protein, and Heat Shock Protein mRNA Expression Levels in Patients with Active Behçet's Uveitis.
Diagnostic yield of heat shock protein 70 (HSP-70) and anti-HSP-70 in Behcet-induced uveitis.
Elevated retina-specific expression of the small heat shock protein, alphaA-crystallin, is associated with photoreceptor protection in experimental uveitis.
Experimental mucosal induction of uveitis with the 60-kDa heat shock protein-derived peptide 336-351.
High levels of IgG class antibodies to recombinant HSP60 kDa of Yersinia enterocolitica in sera of patients with uveitis.
HSP-derived peptides inducing uveitis and IgG and IgA antibodies.
Inhibition of Hsp90 attenuates inflammation in endotoxin-induced uveitis.
Inhibition of RPE cell sterile inflammatory responses and endotoxin-induced uveitis by a cell-impermeable HSP90 inhibitor.
Prevention of mucosally induced uveitis with a HSP60-derived peptide linked to cholera toxin B subunit.
Small heat shock protein ?A-crystallin prevents photoreceptor degeneration in experimental autoimmune uveitis.
Uveitis, Anterior
Chlamydial antibodies in patients with previous acute anterior uveitis.
Vaccinia
CD8+ T cells, NK cells and IFN-gamma are important for control of tumor with downregulated MHC class I expression by DNA vaccination.
Heat shock protein and heat shock factor 1 expression and localization in vaccinia virus infected human monocyte derived macrophages.
Highly persistent and effective prime/boost regimens against tuberculosis that use a multivalent modified vaccine virus Ankara-based tuberculosis vaccine with interleukin-15 as a molecular adjuvant.
Human Hsp60: bacterial expression, purification, development of monoclonal antibodies and a sandwich ELISA for quantitation.
Humoral immune response of BALB/c mice to a vaccinia virus recombinant expressing Brucella abortus GroEL does not correlate with protection against a B. abortus challenge.
Modulation of adjuvant arthritis in Lewis rats by recombinant vaccinia virus expressing the human 60-kilodalton heat shock protein.
Modulation of experimental autoimmunity: treatment of adjuvant arthritis by immunization with a recombinant vaccinia virus.
Molecular chaperone Hsp90 is important for vaccinia virus growth in cells.
siRNA screen of early poxvirus genes identifies the AAA+ ATPase D5 as the virus genome-uncoating factor.
Therapeutic effect of recombinant vaccinia virus expressing the 60-kd heat-shock protein on adjuvant arthritis.
VRK3-mediated nuclear localization of HSP70 prevents glutamate excitotoxicity-induced apoptosis and A? accumulation via enhancement of ERK phosphatase VHR activity.
Vagus Nerve Injuries
Induction of the 27-kDa heat shock protein (Hsp27) in the rat medulla oblongata after vagus nerve injury.
Varicocele
Effect of varicocelectomy treatment on spermatogenesis and apoptosis via the induction of heat shock protein 70 in varicocele?induced rats.
Heat shock protein and heat shock factor expression in sperm: relation to oligozoospermia and varicocele.
Is thioredoxin reductase involved in the defense against DNA fragmentation in varicocele?
Single nucleotide polymorphisms of the heat shock protein 90 gene in varicocele-associated infertility.
Testosterone amplifies HSP70-2a, HSP90 and PCNA expression in experimental varicocele condition: Implication for DNA fragmentation.
Testosterone and vitamin E administration up-regulated varicocele-reduced Hsp70-2 protein expression and ameliorated biochemical alterations.
Vascular Calcification
Effect of endoplasmic reticulum stress-induced apoptosis in the role of periodontitis on vascular calcification in a rat model.
Vascular Diseases
Effect of combined heat, ozonation and ultraviolet irradiation (VasoCare) on heat shock protein expression by peripheral blood leukocyte populations.
Elevated levels of circulating heat shock protein 70 (Hsp70) in peripheral and renal vascular disease.
GRP78 signaling hub a receptor for targeted tumor therapy.
Heat shock protein 27: its potential role in vascular disease.
Heat shock protein 70 is secreted from endothelial cells by a non-classical pathway involving exosomes.
Heat shock protein antibody titers are reduced by statin therapy in dyslipidemic subjects: a pilot study.
Heat shock proteins in vascular disease--a review.
HSP47 in lung fibroblasts is a predictor of survival in fibrotic nonspecific interstitial pneumonia.
HSP60 and anti-HSP60 antibodies in vasculitis: they are two of a kind.
Human heat shock protein 60 stimulates vascular smooth muscle cell proliferation through Toll-like receptors 2 and 4.
Improved Metabolic Control in Diabetes, HSP60, and Proinflammatory Mediators.
Modulation of endothelial cell damages by anti-Hsp60 autoantibodies in systemic autoimmune diseases.
Small molecular weight heat shock-related protein, HSP20, exhibits an anti-platelet activity by inhibiting receptor-mediated calcium influx.
Vascular System Injuries
Attenuation of ischemic brain edema and cerebrovascular injury after ischemic preconditioning in the rat.
Mitochondrial Heat Shock Protein-90 Modulates Vascular Smooth Muscle Cell Survival and the Vascular Injury Response in Vivo.
Vasculitis
HSP60 and anti-HSP60 antibodies in vasculitis: they are two of a kind.
Mitochondrial heat shock protein (HSP) 70 synergizes with HSP60 in transducing endothelial cell apoptosis induced by anti-HSP60 autoantibody.
Vasospasm, Intracranial
Potential role for heat shock protein 72 in antagonizing cerebral vasospasm after rat subarachnoid hemorrhage.
Treatment of experimental cerebral vasospasm by protein transduction of heme oxygenase 1 (HO-1) conjugated to a residue of 11 arginines.
Vector Borne Diseases
GRP78 Is an Important Host Factor for Japanese Encephalitis Virus Entry and Replication in Mammalian Cells.
Venous Thromboembolism
Binding of anti-GRP78 autoantibodies to cell surface GRP78 increases tissue factor procoagulant activity via the release of calcium from endoplasmic reticulum stores.
Ventricular Dysfunction
Regulation of A-Kinase-Anchoring Protein 12 by Heat Shock Protein A12B to Prevent Ventricular Dysfunction Following Acute Myocardial Infarction in Diabetic Rats.
Vertigo
HSP70 antibodies in 80 patients with "clinically certain" Meniere's disease.
Vesicular Stomatitis
Antiviral activity and RNA polymerase degradation following Hsp90 inhibition in a range of negative strand viruses.
Antiviral effect of short hyperthermic treatment at specific stages of vesicular stomatitis virus replication cycle.
Effect of combined alpha IFN and prostaglandin A1 treatment on vesicular stomatitis virus replication and heat shock protein synthesis in epithelial cells.
Endoplasmic reticulum chaperone gp96 is essential for infection with vesicular stomatitis virus.
Heat Shock Protein 70 Enhances Mucosal Immunity against Human Norovirus When Coexpressed from a Vesicular Stomatitis Virus Vector.
HSP90 Chaperoning in Addition to Phosphoprotein Required for Folding but Not for Supporting Enzymatic Activities of Measles and Nipah Virus L Polymerases.
Inhibition of poliovirus replication by prostaglandins A and J in human cells.
Vibrio Infections
Evidence for disruption of Na(+)-K(+)-ATPase and hsp70 during vibriosis of sea bream, Sparus (=Rhabdosargus) sarba Forsskål.
Reactive oxygen species generated by a heat shock protein (Hsp) inducing product contributes to Hsp70 production and Hsp70-mediated protective immunity in Artemia franciscana against pathogenic vibrios.
Viremia
Inhibition of Heat Shock Protein 90 Prevents HIV Rebound.
Virus Diseases
A cellular protein related to heat-shock protein 90 accumulates during herpes simplex virus infection and is overexpressed in transformed cells.
A molecular chaperone glucose-regulated protein 94 blocks apoptosis induced by virus infection.
A plant reovirus hijacks endoplasmic reticulum-associated degradation machinery to promote efficient viral transmission by its planthopper vector under high temperature conditions.
Association of heat-shock protein 70 with lipid rafts is required for Japanese encephalitis virus infection in Huh7 cells.
Atherosclerosis and connective tissue diseases.
Cellular chaperones and folding enzymes are vital contributors to membrane bound replication and movement complexes during plant RNA virus infection.
Cellular DNAJA3, a Novel VP1-Interacting Protein, Inhibits Foot-and-Mouth Disease Virus Replication by Inducing Lysosomal Degradation of VP1 and Attenuating Its Antagonistic Role in the Beta Interferon Signaling Pathway.
Chaperone-mediated in vitro assembly of Polyomavirus capsids.
Chicken Heat Shock Protein 70 Is an Essential Host Protein for Infectious Bursal Disease Virus Infection In Vitro.
Cloning and expression analysis of heat shock cognate 70 gene promoter in tiger shrimp (Penaeus monodon).
COVID-19 and Cell Stress.
Cytoskeletal proteins bound to heat-shock protein 70 may elicit resistance to simian immunodeficiency virus infection of CD4(+) T cells.
Dengue virus infection induces GRP78 which acts to chaperone viral antigen production.
Development and application of Hsp90 inhibitors.
Differential expression of three Paralichthys olivaceus Hsp40 genes in responses to virus infection and heat shock.
Diversity in heat shock protein families: functional implications in virus infection with a comprehensive insight of their role in the HIV-1 life cycle.
Effects of heat treatment on metabolism of tobacco plants infected with Potato virus Y.
Endogenous activated siRNAs in virus-infected Brassicaceae crops show a common host gene silencing pattern affecting photosynthesis and stress-response.
Evidence for an association between heat shock protein 70 and the respiratory syncytial virus polymerase complex within lipid-raft membranes during virus infection.
Functional role of Hsp60 as a positive regulator of human viral infection progression.
GRP78 / BiP / HSPA5 / Dna K is a universal therapeutic target for human disease.
Harnessing an RNA-mediated chaperone for the assembly of influenza hemagglutinin in an immunologically relevant conformation.
HBx protein of hepatitis B virus (HBV) can form complex with mitochondrial HSP60 and HSP70.
Heat shock protein 19.9 (Hsp19.9) from Bombyx mori is involved in host protection against viral infection.
Heat Shock Protein 27 Mediated Signaling in Viral Infection.
Heat shock protein 70 as a supplementary receptor facilitates enterovirus 71 infections in vitro.
Heat shock protein 70 is necessary for Rice stripe virus infection in plants.
Heat shock protein 90 and heat shock protein 70 are components of dengue virus receptor complex in human cells.
Heat Shock Protein 90 Inhibitors: An Update on Achievements, Challenges, and Future Directions.
Heat shock proteins stimulate APOBEC-3-mediated cytidine deamination in the hepatitis B virus.
Heat-shock protein 90? is involved in maintaining the stability of VP16 and VP16-mediated transactivation of ? genes from herpes simplex virus-1.
Hepatitis B virus enhances cisplatin-induced hepatotoxicity via a mechanism involving suppression of glucose-regulated protein of 78 Kda.
Hsc70 regulates the IRES activity and serves as an antiviral target of enterovirus A71 infection.
Hsp70 negatively controls rotavirus protein bioavailability in caco-2 cells infected by the rotavirus RF strain.
Hsp90 inhibitor AT-533 blocks HSV-1 nuclear egress and assembly.
HSP90: a promising broad-spectrum antiviral drug target.
Human Hsp60: bacterial expression, purification, development of monoclonal antibodies and a sandwich ELISA for quantitation.
Identification of Hsp90 as a stimulatory host factor involved in influenza virus RNA synthesis.
In vivo and in vitro association of hsc70 with polyomavirus capsid proteins.
Increased expression of Hsp70 and co-localization with nuclear protein in cells infected with the Hantaan virus.
Inducible transgenic tobacco system to study the mechanisms underlying chlorosis mediated by the silencing of chloroplast heat shock protein 90.
Induction of pro-viral grass carp Ctenopharyngodon idella Hsp70 instead of Hsc70 during infection of grass carp reovirus.
Influence of cytoplasmic heat shock protein 70 on viral infection of Nicotiana benthamiana.
Influenza Virus Infection Induces the Nuclear Relocalization of the Hsp90 Co-Chaperone p23 and Inhibits the Glucocorticoid Receptor Response.
Influenza virus inhibits cleavage of the HSP70 pre-mRNAs at the polyadenylation site.
Inhibition of heat shock protein 90 suppresses Bombyx mori nucleopolyhedrovirus replication in B. mori.
Inhibition of infectious bursal disease virus infection by artificial miRNAs targeting the chicken heat shock protein 90.
Involvement of Hsp90 in assembly and nuclear import of influenza virus RNA polymerase subunits.
Mechanism and Complex Roles of HSC70 in Viral Infections.
Molecular chaperone Hsp90 is important for vaccinia virus growth in cells.
Mortalin restricts porcine epidemic diarrhea virus entry by downregulating clathrin-mediated endocytosis.
Mutagenesis of a functional chimeric gene in yeast identifies mutations in the simian virus 40 large T antigen J domain.
Non-lethal heat shock increased hsp70 and immune protein transcripts but not Vibrio tolerance in the white-leg shrimp.
Oncolytic Newcastle disease virus induces autophagy-dependent immunogenic cell death in lung cancer cells.
Pepino mosaic virus capsid protein interacts with a tomato heat shock protein cognate 70.
Pesticide and pathogen: heat shock protein expression and acetylcholinesterase inhibition in juvenile Chinook salmon in response to multiple stressors.
Protein analysis of purified respiratory syncytial virus particles reveals an important role for heat shock protein 90 in virus particle assembly.
Recombinant heat shock protein 78 enhances enterovirus 71 propagation in Vero cells and is induced in SK-N-SH cells during the infection.
Recruitment of the host plant heat shock protein 70 by Tomato yellow leaf curl virus coat protein is required for virus infection.
RNA interference mediated silencing of Hsp60 gene in human monocytic myeloma cell line U937 revealed decreased dengue virus multiplication.
Role of Heat Shock Proteins (HSP70 and HSP90) in Viral Infection.
Severity of viral infection is promoted by hyperthermic pretreatment.
T cells against a bacterial heat shock protein recognize stressed macrophages.
The 90-kDa heat shock protein protects mammalian cells from thermal stress but not from viral infection.
The antiviral role of heat shock protein 27 against red spotted grouper nervous necrosis virus infection in sea perch.
The Host Heat Shock Protein MRJ/DNAJB6 Modulates Virus Infection.
The interaction of white spot syndrome virus envelope protein VP28 with shrimp Hsc70 is specific and ATP-dependent.
The outcome of poliovirus infections in K562 cells is cytolytic rather than persistent after hemin-induced differentiation.
The Peptide-Binding and ATPase Domains of Recombinant hsc70 Are Required To Interact with Rotavirus and Reduce Its Infectivity.
Tomato plant cell death induced by inhibition of HSP90 is alleviated by Tomato yellow leaf curl virus infection.
Transcriptional activation of endoplasmic reticulum chaperone GRP78 by HCMV IE1-72 protein.
Translation by ribosome shunting on adenovirus and hsp70 mRNAs facilitated by complementarity to 18S rRNA.
Viral infection and serum antibodies to heat shock protein 70 in the acute phase of Ménière's disease.
Virus-heat shock protein interaction and a novel axis for innate antiviral immunity.
Virus-induced gene silencing reveals signal transduction components required for the Pvr9-mediated hypersensitive response in Nicotiana benthamiana.
[Complex of recombinant heat shock protein with lipopolysaccharide induces rapid protection of mice against Salmonella typhimurium and avirulent for humans avian influenza virus H5N2]
Vision Disorders
A rat retinal damage model predicts for potential clinical visual disturbances induced by Hsp90 inhibitors.
Retinal toxicity induced by small-molecule Hsp90 inhibitors in beagle dogs.
Vitamin B 6 Deficiency
Effects of Pyridoxine Deficiency on Hippocampal Function and Its Possible Association with V-Type Proton ATPase Subunit B2 and Heat Shock Cognate Protein 70.
Vitamin D Deficiency
Effects of exogenous vitamin D on endoplasmic reticulum stress-related factors in the vitamin D deficiency rats with cerebral ischemia.
Vitiligo
A central role for inducible heat-shock protein 70 in autoimmune vitiligo.
Autoantigens in Vitiligo Identified by the Serological Selection of a Phage-Displayed Melanocyte cDNA Expression Library.
Enhanced bleaching treatment: opportunities for immune-assisted melanocyte suicide in vitiligo.
Heat Shock Protein-70 Expression in Vitiligo and its Relation to the Disease Activity.
Immunohistochemical expression of heat shock protein 70 in vitiligo.
The multi-target mechanism of Cyclosporin A in the treatment of vitiligo based on network pharmacology.
Treatment with Modified Heat Shock Protein Repigments Vitiligo Lesions in Sinclair Swine.
Vitiligo: How do oxidative stress-induced autoantigens trigger autoimmunity?
Vitreoretinopathy, Proliferative
HBP21: A Novel Member of TPR Motif Family, as a Potential Chaperone of Heat Shock Protein 70 in Proliferative Vitreoretinopathy (PVR) and Breast Cancer.
The anti-proliferative effect of inhibitor of telomerase on cultured retinal pigment epithelial cells.
Vulvar Vestibulitis
Defective regulation of the proinflammatory immune response in women with vulvar vestibulitis syndrome.
Vulvovaginitis
Vaginal heat shock protein expression in symptom-free women with a history of recurrent vulvovaginitis.
Waldenstrom Macroglobulinemia
Expression of heat-shock protein-90 in non-Hodgkin's lymphomas.
Warts
Comparative proteomic analysis of resistant and susceptible potato cultivars during Synchytrium endobioticum infestation.
Whipple Disease
Antibodies against recombinant heat shock protein 65 of Tropheryma whipplei in patients with and without Whipple's disease.
Peripheral T-Cell Reactivity to Heat Shock Protein 70 and Its Cofactor GrpE from Tropheryma whipplei Is Reduced in Patients with Classical Whipple's Disease.
Whooping Cough
Association of the beta gamma subunits of trimeric GTP-binding proteins with 90-kDa heat shock protein, hsp90.
groEL encodes a highly antigenic protein in Burkholderia pseudomallei.
Heterotrimeric Galphaq11 co-immunoprecipitates with surface-anchored GRP78 from plasma membranes of alpha2M*-stimulated macrophages.
Induction of humoral immunity in response to immunization with recombinant Mycobacterium bovis BCG expressing the S1 subunit of Bordetella pertussis toxin.
Priming to heat shock proteins in infants vaccinated against pertussis.
[Effect of heat shock protein 70 on nuclear factor-KappaB/inhibitor protein-alpha of nuclear factor-KappaB in brain edema induced by infection in rat]
Williams Syndrome
Heat shock protein 27 gene: chromosomal and molecular location and relationship to Williams syndrome.
Wilms Tumor
A carcinogenic trigger to study the function of tumor suppressor genes in Schmidtea mediterranea.
Aldosterone signaling regulates the over-expression of claudin-4 and -8 at the distal nephron from type 1 diabetic rats.
Differential expression of the heat shock protein 70 in the histological compartments of nephroblastomas.
Heat shock protein 70/nitric oxide effect on stretched tubular epithelial cells linked to WT-1 cytoprotection during neonatal obstructive nephropathy.
Heat shock protein 90 regulates the expression of Wilms' tumor 1 protein in myeloid leukemias.
Micro RNAs are involved in activation of epicardium during zebrafish heart regeneration.
STA-9090, a small-molecule Hsp90 inhibitor for the potential treatment of cancer.
The expression of HSP70 and HSP90alpha in children with Wilms tumor.
Wilms' tumor 1-associating protein plays an aggressive role in diffuse large B-cell lymphoma and forms a complex with BCL6 via Hsp90.
Wiskott-Aldrich Syndrome
IL-17A regulates Eimeria tenella schizont maturation and migration in avian coccidiosis.
Xeroderma Pigmentosum
Induction of the 72-kD heat shock protein in xeroderma pigmentosum complementation group A fibroblasts.
Involvement of human heat shock protein 90 alpha in nicotine-induced apoptosis.
Yellow Fever
Drinking a hot blood meal elicits a protective heat shock response in mosquitoes.
Identification and characterization of the host protein DNAJC14 as a broadly active flavivirus replication modulator.
Zika Virus Infection
A functional interaction between GRP78 and Zika virus E protein.
Glucose-Regulated Protein 78 Interacts with Zika Virus Envelope Protein and Contributes to a Productive Infection.
Heat shock protein 70 (Hsp70) mediates Zika virus entry, replication, and egress from host cells.
Zoonoses
Hsp100 Molecular Chaperone ClpB and Its Role in Virulence of Bacterial Pathogens.