Information on EC 3.6.3.44 - xenobiotic-transporting ATPase and Organism(s) Homo sapiens and UniProt Accession P08183

ABC-type (ATP-binding cassette-type) ATPase, characterized by the presence of two similar ATP-binding domains. Does not undergo phosphorylation during the transport process. The enzyme from Gram-positive bacteria and eukaryotic cells export a number of drugs, with unusual specificity, covering various groups of unrelated substances, while ignoring some that are closely related structurally. Several distinct enzymes may be present in a single eukaryotic cell. Many of them transport glutathione—drug conjugates. Some also show some ’flippase’ (phospholipid-translocating ATPase; EC 3.6.3.1) activity.