ABC-type (ATP-binding cassette-type) ATPase, characterized by the presence of two similar ATP-binding domains. Does not undergo phosphorylation during the transport process. A bacterial enzyme that imports phosphorylated glycerol.
fosfomycin is widely used to treat urinary tract and pediatric gastrointestinal infections of bacteria. It is supposed that this antibiotic enters cells via two transport systems, including the bacterial glycerol-3-phosphate transporter, GlpT. Impaired function of GlpT is one mechanism for fosfomycin resistance. Interaction of fosfomycin with the recombinant and purified GlpT of Escherichia coli reconstituted in liposomes, overview
the enzymes are members of the G3Pp family, lack of functional redundancy in the gene family, and differential expression patterns of the promoter-GUS fusion transgenics for the G3Pp gene family during seedling growth, overview; the enzymes are members of the G3Pp family, lack of functional redundancy in the gene family, and differential expression patterns of the promoter-GUS fusion transgenics for the G3Pp gene family during seedling growth, overview; the enzymes are members of the G3Pp family, lack of functional redundancy in the gene family, and differential expression patterns of the promoter-GUS fusion transgenics for the G3Pp gene family during seedling growth, overview; the enzymes are members of the G3Pp family, lack of functional redundancy in the gene family, and differential expression patterns of the promoter-GUS fusion transgenics for the G3Pp gene family during seedling growth, overview; the enzymes are members of the G3Pp family, lack of functional redundancy in the gene family, and differential expression patterns of the promoter-GUS fusion transgenics for the G3Pp gene family during seedling growth, overview
the enzymes are members of the G3Pp family, lack of functional redundancy in the gene family, and differential expression patterns of the promoter-GUS fusion transgenics for the G3Pp gene family during seedling growth, overview; the enzymes are members of the G3Pp family, lack of functional redundancy in the gene family, and differential expression patterns of the promoter-GUS fusion transgenics for the G3Pp gene family during seedling growth, overview; the enzymes are members of the G3Pp family, lack of functional redundancy in the gene family, and differential expression patterns of the promoter-GUS fusion transgenics for the G3Pp gene family during seedling growth, overview; the enzymes are members of the G3Pp family, lack of functional redundancy in the gene family, and differential expression patterns of the promoter-GUS fusion transgenics for the G3Pp gene family during seedling growth, overview; the enzymes are members of the G3Pp family, lack of functional redundancy in the gene family, and differential expression patterns of the promoter-GUS fusion transgenics for the G3Pp gene family during seedling growth, overview
the glycerol-3-phosphate transporter is a sugar phosphate/anion antiporter also implicated in phosphate mobilization. G3Pps have a role during seedling growth in Arabidopsis thaliana; the glycerol-3-phosphate transporter is a sugar phosphate/anion antiporter also implicated in phosphate mobilization. G3Pps have a role during seedling growth in Arabidopsis thaliana; the glycerol-3-phosphate transporter is a sugar phosphate/anion antiporter also implicated in phosphate mobilization. G3Pps have a role during seedling growth in Arabidopsis thaliana; the glycerol-3-phosphate transporter is a sugar phosphate/anion antiporter also implicated in phosphate mobilization. G3Pps have a role during seedling growth in Arabidopsis thaliana; the glycerol-3-phosphate transporter is a sugar phosphate/anion antiporter also implicated in phosphate mobilization. G3Pps have a role during seedling growth in Arabidopsis thaliana
the glycerol-3-phosphate transporter is a sugar phosphate/anion antiporter also implicated in phosphate mobilization. G3Pps have a role during seedling growth in Arabidopsis thaliana; the glycerol-3-phosphate transporter is a sugar phosphate/anion antiporter also implicated in phosphate mobilization. G3Pps have a role during seedling growth in Arabidopsis thaliana; the glycerol-3-phosphate transporter is a sugar phosphate/anion antiporter also implicated in phosphate mobilization. G3Pps have a role during seedling growth in Arabidopsis thaliana; the glycerol-3-phosphate transporter is a sugar phosphate/anion antiporter also implicated in phosphate mobilization. G3Pps have a role during seedling growth in Arabidopsis thaliana; the glycerol-3-phosphate transporter is a sugar phosphate/anion antiporter also implicated in phosphate mobilization. G3Pps have a role during seedling growth in Arabidopsis thaliana
GlpT is responsible for secondary active transport of substrate across the cell membrane, which is crucial to many cellular and physiological processes, overview
mechanism for substrate translocation across the membrane that involves a rocker-switch-type movement of the protein, transport assays at different conditions using whole cells or purified enzyme, overview
the enzyme performs G3P/G3P exchange, it shows virtually poor exchange activity using phosphoenolpyruvate, fosfomycin and sulphate, and no activity with glutamate, glutamine, aspartate and ATP. Highest activity in the presence of internal glycerol-3-phosphate and phosphate
GlpT is responsible for secondary active transport of substrate across the cell membrane, which is crucial to many cellular and physiological processes, overview
fosfomycin, externally added to the proteoliposomes, poorly inhibits the glycerol-3-phosphate/glycerol-3-phosphate antiport catalyzed by the reconstituted transporter, completely competitive, interaction of fosfomycin with the recombinant and purified GlpT of Escherichia coli reconstituted in liposomes, overview
differential expression patterns of the promoter-GUS fusion transgenics for the G3Pp gene family during seedling growth, overview; differential expression patterns of the promoter-GUS fusion transgenics for the G3Pp gene family during seedling growth, overview; differential expression patterns of the promoter-GUS fusion transgenics for the G3Pp gene family during seedling growth, overview; differential expression patterns of the promoter-GUS fusion transgenics for the G3Pp gene family during seedling growth, overview; differential expression patterns of the promoter-GUS fusion transgenics for the G3Pp gene family during seedling growth, overview
differential expression patterns of the promoter-GUS fusion transgenics for the G3Pp gene family during seedling growth, overview; differential expression patterns of the promoter-GUS fusion transgenics for the G3Pp gene family during seedling growth, overview; differential expression patterns of the promoter-GUS fusion transgenics for the G3Pp gene family during seedling growth, overview; differential expression patterns of the promoter-GUS fusion transgenics for the G3Pp gene family during seedling growth, overview; differential expression patterns of the promoter-GUS fusion transgenics for the G3Pp gene family during seedling growth, overview
differential expression patterns of the promoter-GUS fusion transgenics for the G3Pp gene family during seedling growth, overview; differential expression patterns of the promoter-GUS fusion transgenics for the G3Pp gene family during seedling growth, overview; differential expression patterns of the promoter-GUS fusion transgenics for the G3Pp gene family during seedling growth, overview; differential expression patterns of the promoter-GUS fusion transgenics for the G3Pp gene family during seedling growth, overview; differential expression patterns of the promoter-GUS fusion transgenics for the G3Pp gene family during seedling growth, overview
differential expression patterns of the promoter-GUS fusion transgenics for the G3Pp gene family during seedling growth, overview; differential expression patterns of the promoter-GUS fusion transgenics for the G3Pp gene family during seedling growth, overview; differential expression patterns of the promoter-GUS fusion transgenics for the G3Pp gene family during seedling growth, overview; differential expression patterns of the promoter-GUS fusion transgenics for the G3Pp gene family during seedling growth, overview; differential expression patterns of the promoter-GUS fusion transgenics for the G3Pp gene family during seedling growth, overview
differential expression patterns of the promoter-GUS fusion transgenics for the G3Pp gene family during seedling growth, overview; differential expression patterns of the promoter-GUS fusion transgenics for the G3Pp gene family during seedling growth, overview; differential expression patterns of the promoter-GUS fusion transgenics for the G3Pp gene family during seedling growth, overview; differential expression patterns of the promoter-GUS fusion transgenics for the G3Pp gene family during seedling growth, overview; differential expression patterns of the promoter-GUS fusion transgenics for the G3Pp gene family during seedling growth, overview
differential expression patterns of the promoter-GUS fusion transgenics for the G3Pp gene family during seedling growth, overview; differential expression patterns of the promoter-GUS fusion transgenics for the G3Pp gene family during seedling growth, overview; differential expression patterns of the promoter-GUS fusion transgenics for the G3Pp gene family during seedling growth, overview; differential expression patterns of the promoter-GUS fusion transgenics for the G3Pp gene family during seedling growth, overview; differential expression patterns of the promoter-GUS fusion transgenics for the G3Pp gene family during seedling growth, overview
the enzyme contains 12-transmembrane alpha-helices which form two domains, each of six transmembrane helices, surrounding a central lingand-binding cavity
the enzyme contains 12 highly flexible transmembrane alpha-helices, H1-H12, which form two domains, each of six transmembrane helices, surrounding a central lingand-binding cavity, molecular dynamic simulations and modelling, comparison of conformational properties with other MFS family members, overview
in complex with glycerol-3-phosphate, sitting drop vapor diffusion method, using 5 mM CoCl3, 5 mM NiCl2, 5 mM CdCl2, 5 mM MgCl2, 0.1 M HEPES, pH 7.5, 12% (w/v) polyethylene glycol 3350, and 0.3% octyl-beta-D-glucopyranoside
X-ray structure, GlpT consists of 12 transmembrane helices, which form a N- and C-terminal domain, the structure reveals a large internal cavity, open toward the cytoplasm but completely closed to the periplasm, the substrate-binding site, formed by two arginine residues, is accessible from only one side of the membrane at a time
gene ArG3Pp3, cloning of 5 genes encoding G3Pps, DNA and amino acid sequence determination and analysis, sequence comparison and phylogenetic analysis. Differential expression patterns of the promoter-GUS fusion transgenics for the G3Pp gene family during seedling growth, overview; gene AtG3Pp1, cloning of 5 genes encoding G3Pps, DNA and amino acid sequence determination and analysis, sequence comparison and phylogenetic analysis. Differential expression patterns of the promoter-GUS fusion transgenics for the G3Pp gene family during seedling growth, overview; gene AtG3Pp2, cloning of 5 genes encoding G3Pps, DNA and amino acid sequence determination and analysis, sequence comparison and phylogenetic analysis. Differential expression patterns of the promoter-GUS fusion transgenics for the G3Pp gene family during seedling growth, overview; gene AtG3Pp4, cloning of 5 genes encoding G3Pps, DNA and amino acid sequence determination and analysis, sequence comparison and phylogenetic analysis. Differential expression patterns of the promoter-GUS fusion transgenics for the G3Pp gene family during seedling growth, overview; gene AtG3Pp5, cloning of 5 genes encoding G3Pps, DNA and amino acid sequence determination and analysis, sequence comparison and phylogenetic analysis. Differential expression patterns of the promoter-GUS fusion transgenics for the G3Pp gene family during seedling growth, overview
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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
gene AtG3Pp1 is induced 24fold in the roots of phosphate-deprived seedlings; gene AtG3Pp2 is induced 3fold in the roots of phosphate-deprived seedlings; phosphate deficiency-mediated induction of AtG3Pp4 is evident in both roots and shoots; phosphate deficiency-mediated induction of gene AtG3Pp3 is evident in both roots and shoots
gene AtG3Pp1 is induced 24fold in the roots of phosphate-deprived seedlings; gene AtG3Pp2 is induced 3fold in the roots of phosphate-deprived seedlings; phosphate deficiency-mediated induction of AtG3Pp4 is evident in both roots and shoots; phosphate deficiency-mediated induction of gene AtG3Pp3 is evident in both roots and shoots
gene AtG3Pp1 is induced 24fold in the roots of phosphate-deprived seedlings; gene AtG3Pp2 is induced 3fold in the roots of phosphate-deprived seedlings; phosphate deficiency-mediated induction of AtG3Pp4 is evident in both roots and shoots; phosphate deficiency-mediated induction of gene AtG3Pp3 is evident in both roots and shoots
Nucleotide sequence of two Clostridium thermosulfurogenes EM1 genes homologous to Escherichia coli genes encoding integral membrane components of binding-protein-dependent transport systems
Wuttge, S.; Bommer, M.; Jaeger, F.; Martins, B.M.; Jacob, S.; Licht, A.; Scheffel, F.; Dobbek, H.; Schneider, E.
Determinants of substrate specificity and biochemical properties of the sn-glycerol-3-phosphate ATP binding cassette transporter (UgpB-AEC2) of Escherichia coli