Information on EC 3.6.2.1 - adenylylsulfatase

for references in articles please use BRENDA:EC3.6.2.1
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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria

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EC NUMBER
COMMENTARY hide
3.6.2.1
-
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RECOMMENDED NAME
GeneOntology No.
adenylylsulfatase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
adenylyl sulfate + H2O = AMP + sulfate
show the reaction diagram
-
-
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of sulfuric acid anhydride
-
-
-
-
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Sulfur metabolism
-
-
Metabolic pathways
-
-
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SYSTEMATIC NAME
IUBMB Comments
adenylyl-sulfate sulfohydrolase
-
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CAS REGISTRY NUMBER
COMMENTARY hide
37289-36-4
-
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
-
-
Manually annotated by BRENDA team
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
3'-phosphoadenosine 5'-phosphosulphate + H2O
adenosine 3',5'-diphosphate + SO42-
show the reaction diagram
-
-
-
?
adenosine 5'-phosphosulfate + H2O
AMP + SO42-
show the reaction diagram
ADP + H2O
?
show the reaction diagram
-
-
-
?
ATP + H2O
?
show the reaction diagram
-
-
-
?
bis(4-nitrophenyl)phosphate + H2O
?
show the reaction diagram
-
-
-
?
diphosphate + H2O
2 phosphate
show the reaction diagram
-
-
-
?
FAD + H2O
?
show the reaction diagram
-
-
-
?
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
adenosine 5'-phosphosulfate + H2O
AMP + SO42-
show the reaction diagram
ADP + H2O
?
show the reaction diagram
-
-
-
?
ATP + H2O
?
show the reaction diagram
-
-
-
?
diphosphate + H2O
2 phosphate
show the reaction diagram
-
-
-
?
FAD + H2O
?
show the reaction diagram
-
-
-
?
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INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
5,5'-dithiobis(2-nitrobenzoate)
-
-
adenosine
-
-
adenosine 2'-monophosphate
-
-
adenosine 3'-monophosphate
-
-
AMP
-
-
Ca2+
-
-
Cu2+
-
-
diphosphate
-
-
ethoxy-formic anhydride
-
-
Fe2+
-
-
Hg2+
-
-
Mg2+
-
-
Mn2+
-
-
Ni2+
-
-
p-mercuribenzoate
-
-
Pb2+
-
-
phosphate
-
-
Rose bengal
-
photo-oxidation
UTP
-
-
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.04 - 9
adenosine 5'-phosphosulfate
0.14
ATP
-
-
0.4
bis(4-nitrophenyl)phosphate
-
-
0.14
phosphate
-
-
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.014 - 0.049
-
different substrates and concentrations
42.2
-
-
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
5 - 6
-
ATP or phosphate as substrate
5.4
-
-
6
-
adenosine 5'-phosphosulfate as substrate
7
-
bis(4-nitrophenyl)phosphate as substrate
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TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
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LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
53000
-
SDS-PAGE
56000
-
gel filtration
68000
-
SDS-PAGE
69000
-
gel filtration
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pH STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
8.5
-
10-15% loss of activity above
289086
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TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0
-
stable for 30 h
additional information
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Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
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APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
pharmacology
-
biological sulfation process
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LINKS TO OTHER DATABASES (specific for EC-Number 3.6.2.1)
ExplorEnz
ExPASy
KEGG
MetaCyc
SABIO-RK
NCBI: PubMed, Protein, Nucleotide, Structure, Genome, OMIM
IUBMB Enzyme Nomenclature
PROSITE Database of protein families and domains
InterPro (database of protein families, domains and functional sites)