Reference on EC 3.6.1.71 - adenosine-5'-diphospho-5'-[DNA] diphosphatase
Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Harris, J.L.; Jakob, B.; Taucher-Scholz, G.; Dianov, G.L.; Becherel, O.J.; Lavin, M.F.
Aprataxin, poly-ADP ribose polymerase 1 (PARP-1) and apurinic endonuclease 1 (APE1) function together to protect the genome against oxidative damage
Hum. Mol. Genet.
18
4102-4117
2009
Homo sapiens (Q7Z2E3)
Sano, Y.; Date, H.; Igarashi, S.; Onodera, O.; Oyake, M.; Takahashi, T.; Hayashi, S.; Morimatsu, M.; Takahashi, H.; Makifuchi, T.; Fukuhara, N.; Tsuji, S.
Aprataxin, the causative protein for EAOH is a nuclear protein with a potential role as a DNA repair protein
Ann. Neurol.
55
241-249
2004
Homo sapiens (Q7Z2E3)
Date, H.; Igarashi, S.; Sano, Y.; Takahashi, T.; Takahashi, T.; Takano, H.; Tsuji, S.; Nishizawa, M.; Onodera, O.
The FHA domain of aprataxin interacts with the C-terminal region of XRCC1
Biochem. Biophys. Res. Commun.
325
1279-1285
2004
Homo sapiens (Q7Z2E3)
Mosesso, P.; Piane, M.; Palitti, F.; Pepe, G.; Penna, S.; Chessa, L.
The novel human gene aprataxin is directly involved in DNA single-strand-break repair
Cell. Mol. Life Sci.
62
485-491
2005
Homo sapiens (FLJ20157), Homo sapiens
Daley, J.M.; Wilson, T.E.; Ramotar, D.
Genetic interactions between HNT3/aprataxin and RAD27/FEN1 suggest parallel pathways for 5' end processing during base excision repair
DNA Repair
9
690-699
2010
Saccharomyces cerevisiae
Gueven, N.; Becherel, O.J.; Kijas, A.W.; Chen, P.; Howe, O.; Rudolph, J.H.; Gatti, R.; Date, H.; Onodera, O.; Taucher-Scholz, G.; Lavin, M.F.
Aprataxin, a novel protein that protects against genotoxic stress
Hum. Mol. Genet.
13
1081-1093
2004
Homo sapiens (Q7Z2E3), Homo sapiens
Becherel, O.J.; Gueven, N.; Birrell, G.W.; Schreiber, V.; Suraweera, A.; Jakob, B.; Taucher-Scholz, G.; Lavin, M.F.
Nucleolar localization of aprataxin is dependent on interaction with nucleolin and on active ribosomal DNA transcription
Hum. Mol. Genet.
15
2239-2249
2006
Homo sapiens (Q7Z2E3), Homo sapiens
Seidle, H.F.; Bieganowski, P.; Brenner, C.
Disease-associated mutations inactivate AMP-lysine hydrolase activity of aprataxin
J. Biol. Chem.
280
20927-20931
2005
Homo sapiens (Q7Z2E3)
Kijas, A.W.; Harris, J.L.; Harris, J.M.; Lavin, M.F.
Aprataxin forms a discrete branch in the HIT (histidine triad) superfamily of proteins with both DNA/RNA binding and nucleotide hydrolase activities
J. Biol. Chem.
281
13939-13948
2006
Homo sapiens (Q7Z2E3)
Moreira, M.C.; Barbot, C.; Tachi, N.; Kozuka, N.; Uchida, E.; Gibson, T.; Mendonca, P.; Costa, M.; Barros, J.; Yanagisawa, T.; Watanabe, M.; Ikeda, Y.; Aoki, M.; Nagata, T.; Coutinho, P.; Sequeiros, J.; Koenig, M.
The gene mutated in ataxia-ocular apraxia 1 encodes the new HIT/Zn-finger protein aprataxin
Nat. Genet.
29
189-193
2001
Homo sapiens (Q7Z2E3)
Tumbale, P.; Appel, C.D.; Kraehenbuehl, R.; Robertson, P.D.; Williams, J.S.; Krahn, J.; Ahel, I.; Williams, R.S.
Structure of an aprataxin-DNA complex with insights into AOA1 neurodegenerative disease
Nat. Struct. Mol. Biol.
18
1189-1195
2011
Schizosaccharomyces pombe (O74859), Schizosaccharomyces pombe, Schizosaccharomyces pombe ATCC 24843 (O74859)
Gong, Y.; Zhu, D.; Ding, J.; Dou, C.N.; Ren, X.; Gu, L.; Jiang, T.; Wang, D.C.
Crystal structures of aprataxin ortholog Hnt3 reveal the mechanism for reversal of 5-adenylated DNA
Nat. Struct. Mol. Biol.
18
1297-1299
2011
Schizosaccharomyces pombe (O74859), Schizosaccharomyces pombe, Schizosaccharomyces pombe ATCC 24843 (O74859)
Ahel, I.; Rass, U.; El-Khamisy, S.F.; Katyal, S.; Clements, P.M.; McKinnon, P.J.; Caldecott, K.W.; West, S.C.
The neurodegenerative disease protein aprataxin resolves abortive DNA ligation intermediates
Nature
443
713-716
2006
Gallus gallus (P61798), Gallus gallus, Mus musculus (Q7TQC5), Mus musculus
Tumbale, P.; Williams, J.S.; Schellenberg, M.J.; Kunkel, T.A.; Williams, R.S.
Aprataxin resolves adenylated RNA-DNA junctions to maintain genome integrity
Nature
506
111-115
2014
Saccharomyces cerevisiae (Q08702), Saccharomyces cerevisiae, Homo sapiens (Q7Z2E3), Homo sapiens, Saccharomyces cerevisiae ATCC 204508 (Q08702)
Becherel, O.J.; Jakob, B.; Cherry, A.L.; Gueven, N.; Fusser, M.; Kijas, A.W.; Peng, C.; Katyal, S.; McKinnon, P.J.; Chen, J.; Epe, B.; Smerdon, S.J.; Taucher-Scholz, G.; Lavin, M.F.
CK2 phosphorylation-dependent interaction between aprataxin and MDC1 in the DNA damage response
Nucleic Acids Res.
38
1489-1503
2010
Homo sapiens (Q7Z2E3)
Chauleau, M.; Jacewicz, A.; Shuman, S.
DNA3pp5G de-capping activity of aprataxin: effect of cap nucleoside analogs and structural basis for guanosine recognition
Nucleic Acids Res.
43
6075-6083
2015
Schizosaccharomyces pombe (O74859), Schizosaccharomyces pombe ATCC 24843 (O74859)
Hanaoka, K.; Tanaka, W.; Kayanuma, M.; Shoji, M.
A QM/MM study of the 5'-AMP DNA hydrolysis of aprataxin
Chem. Phys. Lett.
631-632
16-20
2015
Homo sapiens (Q7Z2E3)
-
Horton, J.K.; Stefanick, D.F.; Caglayan, M.; Zhao, M.L.; Janoshazi, A.K.; Prasad, R.; Gassman, N.R.; Wilson, S.H.
XRCC1 phosphorylation affects aprataxin recruitment and DNA deadenylation activity
DNA Repair
64
26-33
2018
Saccharomyces cerevisiae (Q08702), Homo sapiens (Q7Z2E3)
Tumbale, P.; Schellenberg, M.; Mueller, G.; Fairweather, E.; Watson, M.; Little, J.; Krahn, J.; Waddell, I.; London, R.; Williams, R.
Mechanism of APTX nicked DNA sensing and pleiotropic inactivation in neurodegenerative disease
EMBO J.
37
e98875
2018
Homo sapiens (Q7Z2E3), Homo sapiens
Garcia-Diaz, B.; Barca, E.; Balreira, A.; Lopez, L.C.; Tadesse, S.; Krishna, S.; Naini, A.; Mariotti, C.; Castellotti, B.; Quinzii, C.M.
Lack of aprataxin impairs mitochondrial functions via downregulation of the APE1/NRF1/NRF2 pathway
Hum. Mol. Genet.
24
4516-4529
2015
Homo sapiens (Q7Z2E3), Homo sapiens
Schellenberg, M.J.; Tumbale, P.P.; Williams, R.S.
Molecular underpinnings of Aprataxin RNA/DNA deadenylase function and dysfunction in neurological disease
Prog. Biophys. Mol. Biol.
117
157-165
2015
Homo sapiens (Q7Z2E3)
Raponi, M.; Lancet, J.E.; Fan, H.; Dossey, L.; Lee, G.; Gojo, I.; Feldman, E.J.; Gotlib, J.; Morris, L.E.; Greenberg, P.L.; Wright, J.J.; Harousseau, J.L.; Loewenberg, B.; Stone, R.M.; De Porre, P.; Wang, Y.; Karp, J.E.
A 2-gene classifier for predicting response to the farnesyltransferase inhibitor tipifarnib in acute myeloid leukemia
Blood
111
2589-2596
2008
Homo sapiens (Q7Z2E3)
Marriott, A.S.; Copeland, N.A.; Cunningham, R.; Wilkinson, M.C.; McLennan, A.G.; Jones, N.J.
Diadenosine 5', 5'''-P(1),P(4)-tetraphosphate (Ap4A) is synthesized in response to DNA damage and inhibits the initiation of DNA replication
DNA Repair
33
90-100
2015
Cricetulus griseus (G3I8V7), Homo sapiens (Q7Z2E3)
Rass, U.; Ahel, I.; West, S.C.
Actions of aprataxin in multiple DNA repair pathways
J. Biol. Chem.
282
9469-9474
2007
Homo sapiens (Q7Z2E3)
Rass, U.; Ahel, I.; West, S.C.
Molecular mechanism of DNA deadenylation by the neurological disease protein aprataxin
J. Biol. Chem.
283
33994-34001
2008
Homo sapiens (Q7Z2E3), Homo sapiens
Tumbale, P.; Jurkiw, T.; Schellenberg, M.; Riccio, A.; O'Brien, P.; Williams, R.
Two-tiered enforcement of high-fidelity DNA ligation
Nat. Commun.
10
5431
2019
Homo sapiens
Gong, Y.; Zhu, D.; Ding, J.; Dou, C.N.; Ren, X.; Gu, L.; Jiang, T.; Wang, D.C.
Crystal structures of aprataxin ortholog Hnt3 reveal the mechanism for reversal of 5-adenylated DNA
Nat. Struct. Mol. Biol.
18
1297-1299
2011
Schizosaccharomyces pombe (O74859), Schizosaccharomyces pombe, Schizosaccharomyces pombe 972 (O74859)
Guranowski, A.; Wojdyla, A.; Zimny, J.; Wypijewska, A.; Kowalska, J.; Lukaszewicz, M.; Jemielity, J.; Darzynkiewicz, E.; Jagiello, A.; Bieganowski, P.
Recognition of different nucleotidyl-derivatives as substrates of reactions catalyzed by various HIT-proteins
New J. Chem.
34
888-893
2010
Arabidopsis thaliana (A0A2H1ZE58)
-
html completed
