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Information on EC 3.6.1.69 - 8-oxo-(d)GTP phosphatase

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EC Tree
     3 Hydrolases
         3.6 Acting on acid anhydrides
             3.6.1 In phosphorus-containing anhydrides
                3.6.1.69 8-oxo-(d)GTP phosphatase
IUBMB Comments
The enzyme, characterized from the bacterium Mycobacterium tuberculosis, catalyses the hydrolysis of both 8-oxo-GTP and 8-oxo-dGTP, thereby preventing transcriptional and translational errors caused by oxidative damage. The enzyme is highly specific. Unlike EC 3.6.1.55, 8-oxo-dGTP diphosphatase, it removes only a single phosphate group. The nucleoside diphosphate products are hydrolysed further by EC 3.6.1.58, 8-oxo-dGDP phosphatase.
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Word Map
The expected taxonomic range for this enzyme is: Mycobacteriaceae
Synonyms
MSMEG_2390, mutT1, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
8-oxo-dGTP + H2O = 8-oxo-dGDP + phosphate
show the reaction diagram
(2)
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8-oxo-GTP + H2O = 8-oxo-GDP + phosphate
show the reaction diagram
(1)
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PATHWAY SOURCE
PATHWAYS
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