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Information on EC 3.6.1.66 - XTP/dITP diphosphatase and Organism(s) Homo sapiens and UniProt Accession Q9BY32

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EC Tree
     3 Hydrolases
         3.6 Acting on acid anhydrides
             3.6.1 In phosphorus-containing anhydrides
                3.6.1.66 XTP/dITP diphosphatase
IUBMB Comments
The enzymes from the bacterium Escherichia coli and the archaea Methanococcus jannaschii and Archaeoglobus fulgidus are highly specific for XTP, dITP and ITP. The activity is dependent on divalent cations, Mg2+ is preferred.
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This record set is specific for:
Homo sapiens
UNIPROT: Q9BY32
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Word Map
The taxonomic range for the selected organisms is: Homo sapiens
The expected taxonomic range for this enzyme is: Bacteria, Archaea, Eukaryota
Reaction Schemes
Synonyms
mj0226, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
inosine triphosphate pyrophosphatase
-
inosine triphosphatase
-
-
ITPA
-
-
PATHWAY SOURCE
PATHWAYS
SYSTEMATIC NAME
IUBMB Comments
XTP/dITP diphosphohydrolase (diphosphate-forming)
The enzymes from the bacterium Escherichia coli and the archaea Methanococcus jannaschii and Archaeoglobus fulgidus are highly specific for XTP, dITP and ITP. The activity is dependent on divalent cations, Mg2+ is preferred.
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
dITP + H2O
dIMP + diphosphate
show the reaction diagram
-
-
-
?
dXTP + H2O
dXMP + diphosphate
show the reaction diagram
-
-
-
?
ITP + H2O
IMP + diphosphate
show the reaction diagram
-
-
-
?
XTP + H2O
XMP + diphosphate
show the reaction diagram
-
-
-
?
dITP + H2O
dIMP + diphosphate
show the reaction diagram
-
-
-
-
?
ITP + H2O
IMP + diphosphate
show the reaction diagram
-
-
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
dITP + H2O
dIMP + diphosphate
show the reaction diagram
-
-
-
?
dXTP + H2O
dXMP + diphosphate
show the reaction diagram
-
-
-
?
ITP + H2O
IMP + diphosphate
show the reaction diagram
-
-
-
?
XTP + H2O
XMP + diphosphate
show the reaction diagram
-
-
-
?
dITP + H2O
dIMP + diphosphate
show the reaction diagram
-
-
-
-
?
ITP + H2O
IMP + diphosphate
show the reaction diagram
-
-
-
-
?
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Mg2+
contains Mg2+
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
Uniprot
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
-
enzyme deficiency results in cell growth suppression and DNA instability. Both growth suppression and accumulation of single-strand breaks in nuclear DNA of enzyme-deficient cells depended on MLH1/PMS2
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
ITPA_HUMAN
194
0
21446
Swiss-Prot
-
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
homodimer
-
?
-
x * 20000, SDS-PAGE
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
P32T
inactive
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Dushanov, E.; Koltovaya, N.
Effect of substitution pro32Thr on the interaction between dimer subunits of human phosphatase ITPA
Curr. Enzyme Inhib.
15
46-54
2019
Homo sapiens (Q9BY32)
-
Manually annotated by BRENDA team
Yoneshima, Y.; Abolhassani, N.; Iyama, T.; Sakumi, K.; Shiomi, N.; Mori, M.; Shiomi, T.; Noda, T.; Tsuchimoto, D.; Nakabeppu, Y.
Deoxyinosine triphosphate induces MLH1/PMS2- and p53-dependent cell growth arrest and DNA instability in mammalian cells
Sci. Rep.
6
32849
2016
Homo sapiens, Mus musculus
Manually annotated by BRENDA team