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The enzyme, characterized from the bacterium Escherichia coli, is specific for the pyrimidine nucleotides CTP and dCTP. It also acts on 5-methyl-dCTP, 5-hydroxy-dCTP and 8-hydroxy-dGTP.
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The enzyme appears in viruses and cellular organisms
(d)CTP diphosphohydrolase, (d)CTP pyrophosphohydrolase, MazG, nudG
, Orf135, more
CTP + H2O = CMP + diphosphate
dCTP + H2O = dCMP + diphosphate
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