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The enzyme, which appears to be limited to metazoa, acts on multiple nucleoside diphosphates as well as on D-ribose 5-diphosphate. Specificity depends on species and isoform.
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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
adenosine diphosphatase, adenosinepyrophosphatase, ADPase, At3g04080, At5g18280, AtAPY1, AtAPY2, calcium activated nucleotidase 1, Cant1, CD39, more
a nucleoside diphosphate + H2O = a nucleoside phosphate + phosphate