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Information on EC 3.6.1.59 - 5'-(N7-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase and Organism(s) Mus musculus and UniProt Accession Q9DAR7

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IUBMB Comments
The enzyme removes (decaps) the N7-methylguanosine 5-phosphate cap from an mRNA degraded to a maximal length of 10 nucleotides [3,6]. Decapping is an important process in the control of eukaryotic mRNA degradation. The enzyme functions to clear the cell of cap structure following decay of the RNA body . The nematode enzyme can also decap triply methylated substrates, 5'-(N2,N2,N7-trimethyl 5'-triphosphoguanosine)-[mRNA] .
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This record set is specific for:
Mus musculus
UNIPROT: Q9DAR7
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The taxonomic range for the selected organisms is: Mus musculus
The enzyme appears in selected viruses and cellular organisms
Synonyms
scavenger mrna decapping enzyme, ylr270w, ydcps, m7gpppx pyrophosphatase, more
SYSTEMATIC NAME
IUBMB Comments
5'-(N7-methyl 5'-triphosphoguanosine)-[mRNA] N7-methylguanosine 5'-phosphate phosphohydrolase
The enzyme removes (decaps) the N7-methylguanosine 5-phosphate cap from an mRNA degraded to a maximal length of 10 nucleotides [3,6]. Decapping is an important process in the control of eukaryotic mRNA degradation. The enzyme functions to clear the cell of cap structure following decay of the RNA body [2]. The nematode enzyme can also decap triply methylated substrates, 5'-(N2,N2,N7-trimethyl 5'-triphosphoguanosine)-[mRNA] [4].
pI VALUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
5.4
calculated from sequence
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
SwissProt
Manually annotated by BRENDA team
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
DCPS_MOUSE
338
0
38988
Swiss-Prot
other Location (Reliability: 1)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
37921
x * 37921, calculated from sequence
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
x * 37921, calculated from sequence
CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Han, G.W.; Schwarzenbacher, R.; McMullan, D.; Abdubek, P.; Ambing, E.; Axelrod, H.; Biorac, T.; Canaves, J.M.; Chiu, H.J.; Dai, X.; Deacon, A.M.; DiDonato, M.; Elsliger, M.A.; Godzik, A.; Grittini, C.; Grzechnik, S.K.; Hale, J.; Hampton, E.; Haugen, J.; Hornsby, M.; Jaroszewski, L.; Klock, H.E.; Koesema, E.; Kreusch, A.; Kuhn, P.; Lesley, S.A.; McPhillips, T.M.; Miller, M.D.; Moy, K.; Nigoghossian, E.; Paulsen, J.; Quijano, K.; Reyes, R.; Spraggon, G.; Stevens R.C.; van den Bedem, H.; Velasquez, J.; Vincent, J.; White, A.; Wolf, G.; Xu, Q.; Hodgson, K.O.; Wooley, J.; Wilson, I.A.
Crystal structure of an Apo mRNA decapping enzyme (DcpS) from Mouse at 1.83 A resolution
Proteins
60
797-802
2005
Mus musculus (Q9DAR7)
Manually annotated by BRENDA team