Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
2-hydroxy-ATP + H2O
2-hydroxy-AMP + diphosphate
-
-
-
?
2-hydroxy-dATP + H2O
2-hydroxy-dAMP + diphosphate
-
-
-
?
8-oxo-dATP + H2O
8-oxo-dAMP + diphosphate
-
-
-
?
8-oxo-dGTP + H2O
8-oxo-dGMP + diphosphate
dGTP + H2O
dGMP + diphosphate
-
-
-
?
2-hydroxy-ATP + H2O
2-hydroxy-AMP + diphosphate
-
-
-
-
?
2-hydroxy-dATP + 2 H2O
2-hydroxy-dAMP + 2 phosphate
2-hydroxy-dATP + H2O
2-hydroxy-dAMP + diphosphate
-
-
-
-
?
8-oxo-ATP + H2O
8-oxo-AMP + diphosphate
-
-
-
-
?
8-oxo-dATP + H2O
8-oxo-dAMP + diphosphate
-
-
-
-
?
8-oxo-dGTP + H2O
8-oxo-dGMP + diphosphate
8-oxo-GTP + H2O
8-oxo-GMP + diphosphate
-
8-oxo-dGTP i.e. 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate
-
-
?
8-oxo-dGTP + H2O
8-oxo-dGMP + diphosphate
-
-
-
?
8-oxo-dGTP + H2O
8-oxo-dGMP + diphosphate
8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate (8-oxo-dGTP) is formed in the nucleotide pool of a cell during normal cellular metabolism, and when it is incorporated into DNA causes mutation. Organisms possess 8-oxo-dGTPase, an enzyme that specifically degrades 8-oxo-dGTP to 8-oxo-dGMP. This enzyme is a 2-hydroxy-dATP diphosphatase that also exhibits activity with 8-oxo-dGTP
-
-
?
8-oxo-dGTP + H2O
8-oxo-dGMP + diphosphate
8-oxo-dGTP i.e. 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate. This enzyme is a 2-hydroxy-dATP diphosphatase that also exhibits activity with 8-oxo-dGTP
-
-
?
2-hydroxy-dATP + 2 H2O
2-hydroxy-dAMP + 2 phosphate
-
-
-
-
?
2-hydroxy-dATP + 2 H2O
2-hydroxy-dAMP + 2 phosphate
-
8-oxo-dGTP i.e. 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate. MTH1 protein is an antimutagenic (2'-deoxy) ribonucleoside 5'-triphosphate pyrophosphohydrolase that prevents the incorporation of oxidatively modified nucleotides into nucleic acids. It decomposes most specifically the miscoding products of oxidative damage to purine nucleic acid precursors (e.g. 8-oxo-dGTP, 2-hydroxy-dATP, 2-hydroxy-ATP, 8-oxo-GTP) that may cause point mutations or transcription errors when incorporated into DNA and RNA, respectively
-
-
?
8-oxo-dGTP + H2O
8-oxo-dGMP + diphosphate
-
8-oxo-dGTP i.e. 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate
-
-
?
8-oxo-dGTP + H2O
8-oxo-dGMP + diphosphate
-
8-oxo-dGTP i.e. 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate. MTH1 protein is an antimutagenic (2'-deoxy) ribonucleoside 5'-triphosphate pyrophosphohydrolase that prevents the incorporation of oxidatively modified nucleotides into nucleic acids. It decomposes most specifically the miscoding products of oxidative damage to purine nucleic acid precursors (e.g. 8-oxo-dGTP, 2-hydroxy-dATP, 2-hydroxy-ATP, 8-oxo-GTP) that may cause point mutations or transcription errors when incorporated into DNA and RNA, respectively. This enzyme is a 2-hydroxy-dATP diphosphatase that also exhibits activity with 8-oxo-dGTP
-
-
?
8-oxo-dGTP + H2O
8-oxo-dGMP + diphosphate
-
8-oxo-dGTP i.e. 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate. This enzyme is a 2-hydroxy-dATP diphosphatase that also exhibits activity with 8-oxo-dGTP
-
-
?
8-oxo-dGTP + H2O
8-oxo-dGMP + diphosphate
8-oxo-dGTP i.e. 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate. This enzyme is a 2-hydroxy-dATP diphosphatase that also exhibits activity with 8-oxo-dGTP
-
-
?
8-oxo-dGTP + H2O
8-oxo-dGMP + diphosphate
8-oxo-dGTP i.e. 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate. The MTH2 protein prevents mutations caused by 8-oxoguanine nucleotides. This enzyme is a 2-hydroxy-dATP diphosphatase that also exhibits activity with 8-oxo-dGTP
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
8-oxo-dGTP + H2O
8-oxo-dGMP + diphosphate
8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate (8-oxo-dGTP) is formed in the nucleotide pool of a cell during normal cellular metabolism, and when it is incorporated into DNA causes mutation. Organisms possess 8-oxo-dGTPase, an enzyme that specifically degrades 8-oxo-dGTP to 8-oxo-dGMP. This enzyme is a 2-hydroxy-dATP diphosphatase that also exhibits activity with 8-oxo-dGTP
-
-
?
2-hydroxy-dATP + 2 H2O
2-hydroxy-dAMP + 2 phosphate
-
8-oxo-dGTP i.e. 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate. MTH1 protein is an antimutagenic (2'-deoxy) ribonucleoside 5'-triphosphate pyrophosphohydrolase that prevents the incorporation of oxidatively modified nucleotides into nucleic acids. It decomposes most specifically the miscoding products of oxidative damage to purine nucleic acid precursors (e.g. 8-oxo-dGTP, 2-hydroxy-dATP, 2-hydroxy-ATP, 8-oxo-GTP) that may cause point mutations or transcription errors when incorporated into DNA and RNA, respectively
-
-
?
8-oxo-dGTP + H2O
8-oxo-dGMP + diphosphate
8-oxo-dGTP + H2O
8-oxo-dGMP + diphosphate
-
8-oxo-dGTP i.e. 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate
-
-
?
8-oxo-dGTP + H2O
8-oxo-dGMP + diphosphate
-
8-oxo-dGTP i.e. 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate. MTH1 protein is an antimutagenic (2'-deoxy) ribonucleoside 5'-triphosphate pyrophosphohydrolase that prevents the incorporation of oxidatively modified nucleotides into nucleic acids. It decomposes most specifically the miscoding products of oxidative damage to purine nucleic acid precursors (e.g. 8-oxo-dGTP, 2-hydroxy-dATP, 2-hydroxy-ATP, 8-oxo-GTP) that may cause point mutations or transcription errors when incorporated into DNA and RNA, respectively. This enzyme is a 2-hydroxy-dATP diphosphatase that also exhibits activity with 8-oxo-dGTP
-
-
?
8-oxo-dGTP + H2O
8-oxo-dGMP + diphosphate
8-oxo-dGTP i.e. 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate. This enzyme is a 2-hydroxy-dATP diphosphatase that also exhibits activity with 8-oxo-dGTP
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
high level of activity
brenda
high level of activity
brenda
high level of activity
brenda
high level of activity
brenda
-
-
brenda
-
a statistically significant induction of 8-oxo-dGTPase by 137Cs gamma radiation (given as a single whole-body dose (1 Gy/min)) is found in brains, testes and kidneys but not in lungs, hearts or livers
brenda
-
normal mouse livers and hepatectomized regenerating livers. MTH1 expression is not associated with proliferation rate
brenda
-
a statistically significant induction of 8-oxo-dGTPase by 137Cs gamma radiation (given as a single whole-body dose (1 Gy/min)) is found in brains, testes and kidneys but not in lungs, hearts or livers
brenda
-
a statistically significant induction of 8-oxo-dGTPase by 137Cs gamma radiation (given as a single whole-body dose (1 Gy/min)) is found in brains, testes and kidneys but not in lungs, hearts or livers
brenda
-
oxidative stress in brain induces expression of MTH1 especially in microglia, thus avoiding cellular dysfunction
brenda
-
age-related accumulation of 8-oxoguanine in RNA is correlated with decreased expression of MTH1
brenda
-
excitotoxicity initiated by kainate administration results in an increase ofMTH1protein expression in the mouse hippocampus
brenda
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
physiological function
MTH1 protects the dopamine neurons from oxidative damage in the nucleic acids, especially in the mitochondrial DNA of striatal nerve terminals of dopamine neurons
malfunction
-
MTH1-null mouse embryo fibroblasts are highly susceptible to cell dysfunction and death caused by exposure to H2O2, with condensed nuclei and degenerated mitochondria in which electron dense deposits are seen in place of intact cristae. The cell death observed is not dependent on either poly(ADP-ribose) polymerase or caspases. A continuous accumulation of 8-oxoG, both in the nuclear and mitochondrial DNA, is observed after exposure to H2O2. All of the H2O2-induced alterations observed in MTH1-null MEFs are effectively suppressed by the expression of wild-type human MTH1
physiological function
-
MTH1 efficiently suppresses the accumulation of 8-oxoguanine in both cellular DNA and RNA in the hippocampus, especially in microglia, caused by excitotoxicity (caused by the systemic administration of kainate)
physiological function
-
MTH1, a major sanitizing enzyme for oxidized nucleotide pools plays a crucial role by suppressing their accumulation in cellular DNA. In addition to oxidized purine deoxyribonucleoside triphosphates, MTH1 efficiently hydrolyzes oxidized purine ribonucleoside triphosphates such as 2-hydroxy-ATP, 8-oxo-ATP and, to a lesser extent, 8-oxo-GTP
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Yamaguchi, H.; Kajitani, K.; Dan, Y.; Furuichi, M.; Ohno, M.; Sakumi, K.; Kang, D.; Nakabeppu, Y.
MTH1, an oxidized purine nucleoside triphosphatase, protects the dopamine neurons from oxidative damage in nucleic acids caused by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Cell Death Differ.
13
551-563
2006
Homo sapiens (P36639), Mus musculus (P53368)
brenda
Kajitani, K.; Yamaguchi, H.; Dan, Y.; Furuichi, M.; Kang, D.; Nakabeppu, Y.
MTH1, an oxidized purine nucleoside triphosphatase, suppresses the accumulation of oxidative damage of nucleic acids in the hippocampal microglia during kainate-induced excitotoxicity
J. Neurosci.
26
1688-1698
2006
Mus musculus
brenda
Cai, J.P.; Ishibashi, T.; Takagi, Y.; Hayakawa, H.; Sekiguchi, M.
Mouse MTH2 protein which prevents mutations caused by 8-oxoguanine nucleotides
Biochem. Biophys. Res. Commun.
305
1073-1077
2003
Mus musculus (Q8BG93)
brenda
Bialkowski, K.; Kasprzak, K.S.
Cellular 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate pyrophosphohydrolase activity of human and mouse MTH1 proteins does not depend on the proliferation rate
Free Radic. Biol. Med.
37
1534-1541
2004
Homo sapiens, Mus musculus
brenda
Kakuma, T.; Nishida, J.; Tsuzuki, T.;, Sekiguchi, M.
Mouse MTH1 protein with 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphatase activity that prevents transversion mutation. cDNA cloning and tissue distribution
J. Biol. Chem.
270
25942-25948
1995
Mus musculus (P53368)
brenda
Nakabeppu, Y.; Oka, S.; Sheng, Z.; Tsuchimoto, D.; Sakumi, K.
Programmed cell death triggered by nucleotide pool damage and its prevention by MutT homolog-1 (MTH1) with oxidized purine nucleoside triphosphatase
Mutat. Res.
703
51-58
2010
Homo sapiens, Mus musculus
brenda
Song, X.N.; Zhang, L.Q.; Liu, D.G.; Lin, J.; Zheng, J.D.; Dai, D.P.; Hei, A.L.; Hayakawa, H.; Sekiguchi, M.; Cai, J.P.
Oxidative damage to RNA and expression patterns of MTH1 in the hippocampi of senescence-accelerated SAMP8 mice and Alzheimer's disease patients
Neurochem. Res.
36
1558-1565
2011
Homo sapiens, Mus musculus, Mus musculus SAMP8
brenda
Bialkowski, K.; Szpila, A.; Kasprzak, K.S.
Up-regulation of 8-oxo-dGTPase activity of MTH1 protein in the brain, testes and kidneys of mice exposed to (137)Cs gamma radiation
Radiat. Res.
172
187-197
2009
Mus musculus
brenda
Narwal, M.; Jemth, A.S.; Gustafsson, R.; Almloef, I.; Warpman Berglund, U.; Helleday, T.; Stenmark, P.
Crystal structures and inhibitor interactions of mouse and dog MTH1 reveal species-specific differences in affinity
Biochemistry
57
593-603
2018
Canis lupus familiaris (F1P963), Homo sapiens (P36639), Mus musculus (P53368)
brenda