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adenosine 5'-diphospho-5'-adenosine + H2O
AMP
-
-
45% of the activity with ADP-ribose
-
?
ADP + H2O
?
27% activity at 0.5 mM substrate compared to ADP-ribose
-
-
?
ADP + H2O
AMP + phosphate
ADP-ribose + H2O
AMP + D-ribose 5-phosphate
CDP-choline + H2O
CMP + phosphocholine
CDP-ethanolamine + H2O
?
89% activity at 0.5 mM substrate compared to ADP-ribose
-
-
?
CDP-ethanolamine + H2O
CMP + phosphoethanolamine
CDP-glycerol + H2O
?
89% activity at 0.5 mM substrate compared to ADP-ribose
-
-
?
CDP-glycerol + H2O
CMP + phosphoglycerol
cyclic ADP-ribose + H2O
N1-(5-phosphoribosyl)-AMP
FAD + H2O
?
-
-
39% of the activity with ADP-ribose
-
?
IDP-ribose + H2O
IMP + D-ribose 5-phosphate
-
-
105% of the activity with ADP-ribose
-
?
NAD+ + H2O
?
-
-
23% of the activity with ADP-ribose
-
?
NADH + H+ + H2O
?
-
-
25% of the activity with ADP-ribose
-
?
additional information
?
-
2',3'-cAMP + H2O

?
-
-
-
?
2',3'-cAMP + H2O
?
-
-
-
?
ADP + H2O

AMP + phosphate
-
-
-
?
ADP + H2O
AMP + phosphate
26% of the activity with ADP-ribose
-
-
?
ADP + H2O
AMP + phosphate
-
27% of the activity with ADP-ribose
-
-
?
ADP-ribose + H2O

AMP + D-ribose 5-phosphate
-
-
-
?
ADP-ribose + H2O
AMP + D-ribose 5-phosphate
-
-
-
?
ADP-ribose + H2O
AMP + D-ribose 5-phosphate
-
-
-
-
?
ADP-ribose + H2O
AMP + D-ribose 5-phosphate
-
-
-
?
ADP-ribose + H2O
AMP + D-ribose 5-phosphate
-
best substrate
-
-
?
ADP-ribose + H2O
AMP + D-ribose 5-phosphate
100% activity at 0.5 mM substrate
-
-
?
CDP-choline + H2O

CMP + phosphocholine
-
-
-
?
CDP-choline + H2O
CMP + phosphocholine
-
-
-
?
CDP-choline + H2O
CMP + phosphocholine
-
140% of the activity with ADP-ribose
-
-
?
CDP-choline + H2O
CMP + phosphocholine
156% of the activity with ADP-ribose
-
-
?
CDP-choline + H2O
CMP + phosphocholine
140% activity at 0.5 mM substrate compared to ADP-ribose
-
-
?
CDP-ethanolamine + H2O

CMP + phosphoethanolamine
-
-
-
?
CDP-ethanolamine + H2O
CMP + phosphoethanolamine
84% of the activity with ADP-ribose
-
-
?
CDP-ethanolamine + H2O
CMP + phosphoethanolamine
-
89% of the activity with ADP-ribose
-
-
?
CDP-glycerol + H2O

CMP + phosphoglycerol
-
-
-
?
CDP-glycerol + H2O
CMP + phosphoglycerol
103% of the activity with ADP-ribose
-
-
?
CDP-glycerol + H2O
CMP + phosphoglycerol
-
89% of the activity with ADP-ribose
-
-
?
cyclic ADP-ribose + H2O

N1-(5-phosphoribosyl)-AMP
-
-
-
?
cyclic ADP-ribose + H2O
N1-(5-phosphoribosyl)-AMP
-
-
-
?
cyclic ADP-ribose + H2O
N1-(5-phosphoribosyl)-AMP
-
cADPR is an ADPRibase-Mn ligand and substrate
-
-
?
cyclic ADP-ribose + H2O
N1-(5-phosphoribosyl)-AMP
-
ADPRibase-Mn activity on cyclic ADP-ribose is 65fold less efficient than on ADP-ribose
-
-
?
cyclic ADP-ribose + H2O
N1-(5-phosphoribosyl)-AMP
-
product determination and analysis, cADPR is an ADPRibase-Mn ligand and substrate. ADPRibase-Mn activity on cADPR is 65fold less efficient than on ADP-ribose, the best substrate. Phosphohydrolytic pattern of the reaction, overview
-
-
?
additional information

?
-
-
very poor substrate: cyclic ADP-ribose. No substrate: ADP-glucose, UDP-glucose, CDP-glucose, CDP, CMP, AMP or 3',5'-cAMP
-
-
-
additional information
?
-
very poor substrate: cyclic ADP-ribose. No substrate: ADP-glucose, UDP-glucose, CDP-glucose, CDP, CMP, AMP or 3',5'-cAMP
-
-
-
additional information
?
-
-
ADPRibase-Mn hydrolyzes the phosphoanhydride linkages of ADP-ribose, CDP-choline, CDP-glycerol, CDP-ethanolamine, and ADP with decreasing efficiencies, requiring low micromolar Mn2+ concentrations not substituted by Mg2+. ADPRibase-Mn hydrolyzes ADP-ribose, CDP-choline, CDP-glycerol and CDP-ethanolamine with decreasing catalytic efficiencies
-
-
-
additional information
?
-
ADP-glucose, UDP-glucose, CDP-glucose, CDP, CMP, and AMP are not hydrolysed
-
-
-
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1.422 - 31
CDP-ethanolamine
0.17 - 0.78
cyclic ADP-ribose
0.76
2',3'-cAMP

wild-type, pH 7.5, temperature not specified in the publication
1.05
2',3'-cAMP
mutant N110A, pH 7.5, 37°C
1.25
2',3'-cAMP
mutant H111A, pH 7.5, 37°C
1.7
2',3'-cAMP
mutant H97A, pH 7.5, temperature not specified in the publication
1.8
2',3'-cAMP
mutant H111N, pH 7.5, 37°C
2.3
2',3'-cAMP
mutant Q27H, pH 7.5, 37°C
2.4
2',3'-cAMP
wild-type, pH 7.5, 37°C
2.5
2',3'-cAMP
mutant F37Y, pH 7.5, 37°C
2.6
2',3'-cAMP
mutant C253A, pH 7.5, 37°C
3.4
2',3'-cAMP
mutant L196A, pH 7.5, 37°C
4.8
2',3'-cAMP
mutant F37A/L196A, pH 7.5, 37°C
5.1
2',3'-cAMP
mutant F37A, pH 7.5, 37°C
5.2
2',3'-cAMP
mutant F37A/L196F/C253A, pH 7.5, 37°C
7.1
2',3'-cAMP
mutant F37A/L196F, pH 7.5, 37°C
7.6
2',3'-cAMP
mutant F210A, pH 7.5, 37°C; mutant R43A, pH 7.5, 37°C
0.201
ADP

pH 7.5, 37°C; recombinant enzyme, in 50 mM Tris-HCl (pH 7.5), 0.1 mM MnCl2, at 37°C
2.65
ADP
wild-type, pH 7.5, temperature not specified in the publication
19
ADP
mutant H97A, pH 7.5, temperature not specified in the publication
0.015
ADP-ribose

-
pH 7.5, 37°C
0.039
ADP-ribose
pH 7.5, 37°C; recombinant enzyme, in 50 mM Tris-HCl (pH 7.5), 0.1 mM MnCl2, at 37°C
0.053
ADP-ribose
wild-type, pH 7.5, temperature not specified in the publication
0.06
ADP-ribose
wild-type, pH 7.5, 37°C
0.071
ADP-ribose
mutant H97A, pH 7.5, temperature not specified in the publication
0.077
ADP-ribose
mutant F37Y, pH 7.5, 37°C
0.078
ADP-ribose
mutant H111N, pH 7.5, 37°C
0.094
ADP-ribose
mutant C253A, pH 7.5, 37°C
0.115
ADP-ribose
mutant R43A, pH 7.5, 37°C
0.13
ADP-ribose
mutant L196A, pH 7.5, 37°C
0.14
ADP-ribose
mutant H111A, pH 7.5, 37°C
0.2
ADP-ribose
mutant Q27H, pH 7.5, 37°C
0.29
ADP-ribose
mutant N110A, pH 7.5, 37°C
1.15
ADP-ribose
mutant F37A/L196A, pH 7.5, 37°C; mutant F37A, pH 7.5, 37°C
1.2
ADP-ribose
mutant F37A/L196F/C253A, pH 7.5, 37°C
1.6
ADP-ribose
mutant F37A/L196F, pH 7.5, 37°C
2.1
ADP-ribose
mutant F210A, pH 7.5, 37°C
0.3
CDP-choline

pH 7.5, 37°C; recombinant, in 50 mM Tris-HCl (pH 7.5), 0.1 mM MnCl2, at 37°C
0.35
CDP-choline
wild-type, pH 7.5, 37°C
0.43
CDP-choline
mutant F37Y, pH 7.5, 37°C
0.47
CDP-choline
mutant L196A, pH 7.5, 37°C
0.5
CDP-choline
mutant C253A, pH 7.5, 37°C
0.97
CDP-choline
mutant F37A, pH 7.5, 37°C
1.25
CDP-choline
mutant F37A/L196A, pH 7.5, 37°C
1.5
CDP-choline
mutant F37A/L196F, pH 7.5, 37°C
1.7
CDP-choline
mutant F37A/L196F/C253A, pH 7.5, 37°C
2.7
CDP-choline
mutant H111N, pH 7.5, 37°C; mutant Q27H, pH 7.5, 37°C
4
CDP-choline
mutant N110A, pH 7.5, 37°C
7.5
CDP-choline
mutant H111A, pH 7.5, 37°C
9
CDP-choline
mutant R43A, pH 7.5, 37°C
11
CDP-choline
mutant F210A, pH 7.5, 37°C
12
CDP-choline
wild-type, pH 7.5, temperature not specified in the publication
43
CDP-choline
mutant H97A, pH 7.5, temperature not specified in the publication
1.422
CDP-ethanolamine

pH 7.5, 37°C; recombinant enzyme, in 50 mM Tris-HCl (pH 7.5), 0.1 mM MnCl2, at 37°C
3.9
CDP-ethanolamine
wild-type, pH 7.5, temperature not specified in the publication
31
CDP-ethanolamine
mutant H97A, pH 7.5, temperature not specified in the publication
0.304
CDP-glycerol

pH 7.5, 37°C; recombinant enzyme, in 50 mM Tris-HCl (pH 7.5), 0.1 mM MnCl2, at 37°C
2
CDP-glycerol
wild-type, pH 7.5, temperature not specified in the publication
6.3
CDP-glycerol
mutant H97A, pH 7.5, temperature not specified in the publication
0.17
cyclic ADP-ribose

-
pH 8.5, 25°C
0.19
cyclic ADP-ribose
wild-type, pH 7.5, temperature not specified in the publication
0.2
cyclic ADP-ribose
mutant C253A, pH 7.5, 37°C
0.46
cyclic ADP-ribose
mutant F37A/L196F/C253A, pH 7.5, 37°C
0.78
cyclic ADP-ribose
wild-type, pH 7.5, 37°C
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2.1 - 125.2
CDP-ethanolamine
0.005 - 16
cyclic ADP-ribose
0.11
2',3'-cAMP

mutant N110A, pH 7.5, 37°C
0.95
2',3'-cAMP
mutant R43A, pH 7.5, 37°C
2 - 8
2',3'-cAMP
mutant F37A/L196F, pH 7.5, 37°C
2.7
2',3'-cAMP
mutant F210A, pH 7.5, 37°C
3 - 6
2',3'-cAMP
mutant F37A, pH 7.5, 37°C
4.3
2',3'-cAMP
mutant Q27H, pH 7.5, 37°C
7.4
2',3'-cAMP
mutant H111A, pH 7.5, 37°C
16.9
2',3'-cAMP
wild-type, pH 7.5, temperature not specified in the publication
19
2',3'-cAMP
mutant F37A/L196A, pH 7.5, 37°C
20
2',3'-cAMP
mutant F37A/L196F/C253A, pH 7.5, 37°C
29.7
2',3'-cAMP
mutant H97A, pH 7.5, temperature not specified in the publication
30
2',3'-cAMP
mutant L196A, pH 7.5, 37°C
34
2',3'-cAMP
mutant H111N, pH 7.5, 37°C
60
2',3'-cAMP
wild-type, pH 7.5, 37°C
70
2',3'-cAMP
mutant F37Y, pH 7.5, 37°C
83
2',3'-cAMP
mutant C253A, pH 7.5, 37°C
0.2
ADP

mutant H97A, pH 7.5, temperature not specified in the publication
1.8
ADP
wild-type, pH 7.5, temperature not specified in the publication
4.4
ADP
pH 7.5, 37°C; recombinant enzyme, in 50 mM Tris-HCl (pH 7.5), 0.1 mM MnCl2, at 37°C
0.003
ADP-ribose

mutant R43A, pH 7.5, 37°C
0.4
ADP-ribose
mutant H97A, pH 7.5, temperature not specified in the publication
0.47
ADP-ribose
mutant H111A, pH 7.5, 37°C
2.3
ADP-ribose
mutant H111N, pH 7.5, 37°C
4.3
ADP-ribose
mutant N110A, pH 7.5, 37°C
7
ADP-ribose
mutant F37A/L196A, pH 7.5, 37°C
8
ADP-ribose
mutant F37A/L196F, pH 7.5, 37°C
10
ADP-ribose
mutant Q27H, pH 7.5, 37°C
12.8
ADP-ribose
pH 7.5, 37°C; recombinant enzyme, in 50 mM Tris-HCl (pH 7.5), 01 mM MnCl2, at 37°C
13
ADP-ribose
mutant F37A/L196F/C253A, pH 7.5, 37°C
14
ADP-ribose
mutant F37A, pH 7.5, 37°C
16
ADP-ribose
mutant L196A, pH 7.5, 37°C
18
ADP-ribose
wild-type, pH 7.5, temperature not specified in the publication
19
ADP-ribose
mutant F210A, pH 7.5, 37°C
35
ADP-ribose
wild-type, pH 7.5, 37°C
50
ADP-ribose
mutant F37Y, pH 7.5, 37°C
97
ADP-ribose
mutant C253A, pH 7.5, 37°C
0.025
CDP-choline

mutant R43A, pH 7.5, 37°C
0.8
CDP-choline
mutant H97A, pH 7.5, temperature not specified in the publication
2.2
CDP-choline
mutant H111A, pH 7.5, 37°C
5.3
CDP-choline
mutant H111N, pH 7.5, 37°C
5.7
CDP-choline
mutant N110A, pH 7.5, 37°C
25
CDP-choline
mutant F37A/L196A, pH 7.5, 37°C
26
CDP-choline
mutant F37A/L196F, pH 7.5, 37°C
28.5
CDP-choline
pH 7.5, 37°C; recombinant enzyme, in 50 mM Tris-HCl (pH 7.5), 0.1 mM MnCl2, at 37°C
29
CDP-choline
mutant L196A, pH 7.5, 37°C
33
CDP-choline
mutant F37A, pH 7.5, 37°C
37
CDP-choline
mutant F37A/L196F/C253A, pH 7.5, 37°C
39
CDP-choline
mutant Q27H, pH 7.5, 37°C
50
CDP-choline
mutant F210A, pH 7.5, 37°C; wild-type, pH 7.5, 37°C
67.2
CDP-choline
wild-type, pH 7.5, temperature not specified in the publication
76
CDP-choline
mutant F37Y, pH 7.5, 37°C
79
CDP-choline
mutant C253A, pH 7.5, 37°C
2.1
CDP-ethanolamine

mutant H97A, pH 7.5, temperature not specified in the publication
41.3
CDP-ethanolamine
pH 7.5, 37°C; recombinant enzyme, in 50 mM Tris-HCl (pH 7.5), 0.1 mM MnCl2, at 37°C
125.2
CDP-ethanolamine
wild-type, pH 7.5, temperature not specified in the publication
0.8
CDP-glycerol

mutant H97A, pH 7.5, temperature not specified in the publication
28.1
CDP-glycerol
pH 7.5, 37°C; recombinant enzyme, in 50 mM Tris-HCl (pH 7.5), 0.1 mM MnCl2, at 37°C
95.6
CDP-glycerol
wild-type, pH 7.5, temperature not specified in the publication
0.005
cyclic ADP-ribose

wild-type, pH 7.5, temperature not specified in the publication
0.87
cyclic ADP-ribose
-
pH 8.5, 25°C
3.2
cyclic ADP-ribose
wild-type, pH 7.5, 37°C
8.9
cyclic ADP-ribose
mutant C253A, pH 7.5, 37°C
16
cyclic ADP-ribose
mutant F37A/L196F/C253A, pH 7.5, 37°C
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
0.07 - 32
CDP-ethanolamine
0.0001 - 44
cyclic ADP-ribose
0.1
2',3'-cAMP

mutant N110A, pH 7.5, 37°C
0.13
2',3'-cAMP
mutant R43A, pH 7.5, 37°C
0.4
2',3'-cAMP
mutant F210A, pH 7.5, 37°C
1.9
2',3'-cAMP
mutant Q27H, pH 7.5, 37°C
3.9
2',3'-cAMP
mutant F37A/L196F, pH 7.5, 37°C
4
2',3'-cAMP
mutant F37A/L196A, pH 7.5, 37°C; mutant F37A/L196F/C253A, pH 7.5, 37°C
6
2',3'-cAMP
mutant H111A, pH 7.5, 37°C
7
2',3'-cAMP
mutant F37A, pH 7.5, 37°C
9
2',3'-cAMP
mutant L196A, pH 7.5, 37°C
18
2',3'-cAMP
mutant H97A, pH 7.5, temperature not specified in the publication
19
2',3'-cAMP
mutant H111N, pH 7.5, 37°C
22
2',3'-cAMP
wild-type, pH 7.5, temperature not specified in the publication
25
2',3'-cAMP
wild-type, pH 7.5, 37°C
28
2',3'-cAMP
mutant F37Y, pH 7.5, 37°C
32
2',3'-cAMP
mutant C253A, pH 7.5, 37°C
0.011
ADP

mutant H97A, pH 7.5, temperature not specified in the publication
0.66
ADP
wild-type, pH 7.5, temperature not specified in the publication
0.03
ADP-ribose

mutant R43A, pH 7.5, 37°C
3
ADP-ribose
mutant H111A, pH 7.5, 37°C
4.8
ADP-ribose
mutant F37A/L196F, pH 7.5, 37°C
5.9
ADP-ribose
mutant H97A, pH 7.5, temperature not specified in the publication
6
ADP-ribose
mutant F37A/L196A, pH 7.5, 37°C
9
ADP-ribose
mutant F210A, pH 7.5, 37°C
11
ADP-ribose
mutant F37A/L196F/C253A, pH 7.5, 37°C
12
ADP-ribose
mutant F37A, pH 7.5, 37°C
15
ADP-ribose
mutant N110A, pH 7.5, 37°C
29
ADP-ribose
mutant H111N, pH 7.5, 37°C
52
ADP-ribose
mutant Q27H, pH 7.5, 37°C
120
ADP-ribose
mutant L196A, pH 7.5, 37°C
340
ADP-ribose
wild-type, pH 7.5, temperature not specified in the publication
590
ADP-ribose
wild-type, pH 7.5, 37°C
650
ADP-ribose
mutant F37Y, pH 7.5, 37°C
1000
ADP-ribose
mutant C253A, pH 7.5, 37°C
0.006
CDP-choline

mutant R43A, pH 7.5, 37°C
0.02
CDP-choline
mutant H97A, pH 7.5, temperature not specified in the publication
0.3
CDP-choline
mutant H111A, pH 7.5, 37°C
1.5
CDP-choline
mutant N110A, pH 7.5, 37°C
2
CDP-choline
mutant H111N, pH 7.5, 37°C
4
CDP-choline
mutant F210A, pH 7.5, 37°C
5.6
CDP-choline
wild-type, pH 7.5, temperature not specified in the publication
14
CDP-choline
mutant Q27H, pH 7.5, 37°C
17
CDP-choline
mutant F37A/L196F, pH 7.5, 37°C
21
CDP-choline
mutant F37A/L196A, pH 7.5, 37°C
22
CDP-choline
mutant F37A/L196F/C253A, pH 7.5, 37°C
34
CDP-choline
mutant F37A, pH 7.5, 37°C
62
CDP-choline
mutant L196A, pH 7.5, 37°C
150
CDP-choline
wild-type, pH 7.5, 37°C
160
CDP-choline
mutant C253A, pH 7.5, 37°C
180
CDP-choline
mutant F37Y, pH 7.5, 37°C
0.07
CDP-ethanolamine

mutant H97A, pH 7.5, temperature not specified in the publication
32
CDP-ethanolamine
wild-type, pH 7.5, temperature not specified in the publication
0.12
CDP-glycerol

mutant H97A, pH 7.5, temperature not specified in the publication
48
CDP-glycerol
wild-type, pH 7.5, temperature not specified in the publication
0.0001
cyclic ADP-ribose

mutant R43A, pH 7.5, 37°C
0.028
cyclic ADP-ribose
wild-type, pH 7.5, temperature not specified in the publication
0.07
cyclic ADP-ribose
mutant H111A, pH 7.5, 37°C
0.08
cyclic ADP-ribose
mutant F210A, pH 7.5, 37°C
0.13
cyclic ADP-ribose
mutant N110A, pH 7.5, 37°C
0.15
cyclic ADP-ribose
mutant Q27H, pH 7.5, 37°C
0.29
cyclic ADP-ribose
mutant H111N, pH 7.5, 37°C
0.9
cyclic ADP-ribose
mutant F37A/L196A, pH 7.5, 37°C; mutant L196A, pH 7.5, 37°C
1.3
cyclic ADP-ribose
mutant F37A, pH 7.5, 37°C
1.6
cyclic ADP-ribose
mutant F37A/L196F, pH 7.5, 37°C
4
cyclic ADP-ribose
wild-type, pH 7.5, 37°C
4.1
cyclic ADP-ribose
mutant F37Y, pH 7.5, 37°C
35.5
cyclic ADP-ribose
mutant F37A/L196F/C253A, pH 7.5, 37°C
44
cyclic ADP-ribose
mutant C253A, pH 7.5, 37°C
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
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H97A
severe reduction of activtiy
C253A
10fold increase of the catalytic efficiency for cyclic ADP-ribose; Cys253 is hindering for cADPR phosphohydrolase activity, specific tenfold gain of efficiency with cyclic ADP-ribose
F210A
mutation lowers 40-70fold the catalytic efficiency for ADP-ribose, CDP-choline and 2',3'-cAMP hydrolysis, and 500fold for cyclic ADP-ribose
F37A
Phe37 is needed for ADP-ribose preference without catalytic effect
F37A/L196A
modest enhancement of the inhibitory effect over that of the F37A point mutation
F37A/L196F
modest enhancement of the inhibitory effect over that of the F37A point mutation
F37A/L196F/C253A
cyclic ADP-ribose is the best substrate, with a 8fold increase in catalytic efficiency compared to wild-type
F37Y
kinetic parameters similar to wild-type
H111A
marked decrease in efficiency with all substrates except 2',3'-cAMP
H111N
marked decrease in efficiency with all substrates except 2',3'-cAMP
L196A
modest 2-5fold decrease of catalytic efficiency with the substrates tested
N110A
reduction of catalytic efficiency is stronger for the hydrolysis of CDP-choline or 2',3'-cAMP than for the hydrolysis of ADP-ribose or cADPR. The decrease of kcat value is stronger for the hydrolysis of 2',3'-cAMP
Q27H
for ADP-ribose, modest negative effects of similar magnitude in catalysis and in substrate binding. For CDP-choline, the substitution affects only binding. For 2',3'-cAMP, the substitution affects catalysis, not binding
R43A
Arg43 is essential for catalysis, drastic efficiency loss of the mutant
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Canales, J.; Pinto, R.M.; Costas, M.J.; Hernandez, M.T.; Miro, A.; Bernet, D.; Fernandez, A.; Cameselle, J.C.
Rat liver nucleoside diphosphosugar or diphosphoalcohol pyrophosphatase different from nucleotide pyrophosphatase or phosphodiesterase I: substrate specificities of Mg2+- and/or Mn2+-depeneent hydrolases acting on ADP-ribose
Biochim. Biophys. Acta
1246
167-177
1995
Rattus norvegicus
brenda
Canales, J.; Fernandez, A.; Ribeiro, J.M.; Cabezas, A.; Rodrigues, J.R.; Cameselle, J.C.; Costas, M.J.
Mn2+-dependent ADP-ribose/CDP-alcohol pyrophosphatase: a novel metallophosphoesterase family preferentially expressed in rodent immune cells
Biochem. J.
413
103-113
2008
Mus musculus, Mus musculus (Q99KS6), Rattus norvegicus (Q5M886)
brenda
Canales, J.; Fernandez, A.; Rodrigues, J.R.; Ferreira, R.; Ribeiro, J.M.; Cabezas, A.; Costas, M.J.; Cameselle, J.C.
Hydrolysis of the phosphoanhydride linkage of cyclic ADP-ribose by the Mn(2+)-dependent ADP-ribose/CDP-alcohol pyrophosphatase
FEBS Lett.
583
1593-1598
2009
Rattus norvegicus
brenda
Cabezas, A.; Ribeiro, J.; Rodrigues, J.; Lopez-Villamizar, I.; Fernandez, A.; Canales, J.; Pinto, R.; Costas, M.; Cameselle, J.
Molecular bases of catalysis and ADP-ribose preference of human Mn2+-dependent adpribose/CDP-alcohol diphosphatase and conversion by mutagenesis to a preferential cyclic ADP-ribose phosphohydrolase
PLoS ONE
10
e0118680
2015
Homo sapiens, Homo sapiens (W0NWJ0)
brenda
Rodrigues, J.; Fernandez, A.; Canales, J.; Cabezas, A.; Ribeiro, J.; Costas, M.; Cameselle, J.
Characterization of Danio rerio Mn2+-dependent ADP-ribose/CDP-alcohol diphosphatase, the structural prototype of the ADPRibase-Mn-like protein family
PLoS ONE
7
e42249
2012
Danio rerio, Danio rerio (Q7T291)
brenda