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Information on EC 3.6.1.5 - apyrase

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EC Tree
     3 Hydrolases
         3.6 Acting on acid anhydrides
             3.6.1 In phosphorus-containing anhydrides
                3.6.1.5 apyrase
IUBMB Comments
Apyrases are active against both di- and triphosphate nucleotides (NDPs and NTPs) and hydrolyse NTPs to nucleotide monophosphates (NMPs) in two distinct successive phosphate-releasing steps, with NDPs as intermediates. They differ from ATPases, which specifically hydrolyse ATP, by hydrolysing both ATP and ADP. The eukaryotic enzymes requires Ca2+, but Mg2+ can substitute. Most of the ecto-ATPases that occur on the cell surface and hydrolyse extracellular nucleotides belong to this enzyme family.
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Word Map
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Reaction Schemes
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Synonyms
ecto-atpase, adpase, ntpdase2, ntpdase1, atp diphosphohydrolase, e-ntpdase, ecto-apyrase, atpdase, ectonucleoside triphosphate diphosphohydrolase, adenosine diphosphatase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
a nucleoside 5'-diphosphate + H2O = a nucleoside 5'-phosphate + phosphate
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(1b)
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a nucleoside 5'-triphosphate + 2 H2O = a nucleoside 5'-phosphate + 2 phosphate
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overall reaction
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a nucleoside 5'-triphosphate + H2O = a nucleoside 5'-diphosphate + phosphate
show the reaction diagram
(1a)
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