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Information on EC 3.6.1.45 - UDP-sugar diphosphatase

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EC Tree
     3 Hydrolases
         3.6 Acting on acid anhydrides
             3.6.1 In phosphorus-containing anhydrides
                3.6.1.45 UDP-sugar diphosphatase
IUBMB Comments
A divalent cation is required for activity. UDP-sugar is the best substrate, although other nucleoside-sugar diphosphates are used as substrates with similar Km values but much lower maximum velocities. Thus, this enzyme has a specificity distinct from that of ADP-sugar diphosphatase (EC 3.6.1.21). Some but not all enzymes of this class also appear to have 5'-nucleotidase (see EC 3.1.3.5) activity.
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Word Map
  • 3.6.1.45
  • cholera
  • clostridium
  • difficile
  • mucosal
  • retrograde
  • diarrhea
  • gm1
  • stool
  • afferent
  • tracer
  • ganglioside
  • innervation
  • anterograde
  • toxigenic
  • intranasal
  • colitis
  • enterotoxin
  • nosocomial
  • antibiotic-associated
  • difficile-associated
  • rostral
  • pseudomembranous
  • tracing
  • botulinum
  • cytotoxin
  • parvicellular
  • transganglionic
  • preganglionic
  • parabrachial
  • enterotoxigenic
  • intermediolateral
  • ambiguus
  • non-toxigenic
  • antitoxin
  • fluoro-gold
  • gm1-ganglioside
  • toxoid
  • antibody-secreting
  • ribotype
  • sordellii
  • ventrolateral
  • vglut2
  • shiga
  • tract-tracing
  • pentameric
  • holotoxin
  • leucoagglutinin
  • exotoxin
  • cdta
  • adjuvanticity
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Synonyms
toxin b, udp-sugar hydrolase, ugppase, udp-glucose pyrophosphatase, udp-sugar pyrophosphatase, ushb protein, udpg pyrophosphatase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
UDP-sugar + H2O = UMP + alpha-D-aldose 1-phosphate
show the reaction diagram
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