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Information on EC 3.6.1.45 - UDP-sugar diphosphatase

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EC Tree
     3 Hydrolases
         3.6 Acting on acid anhydrides
             3.6.1 In phosphorus-containing anhydrides
                3.6.1.45 UDP-sugar diphosphatase
IUBMB Comments
A divalent cation is required for activity. UDP-sugar is the best substrate, although other nucleoside-sugar diphosphates are used as substrates with similar Km values but much lower maximum velocities. Thus, this enzyme has a specificity distinct from that of ADP-sugar diphosphatase (EC 3.6.1.21). Some but not all enzymes of this class also appear to have 5'-nucleotidase (see EC 3.1.3.5) activity.
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Word Map
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Synonyms
5'-nucleotidase/UDP-sugar hydrolase, hydrolase, uridine diphosphoglucose (Escherichia coli precursor reduced), hydrolase, uridine diphosphoglucose (Escherichia coli reduced), hydrolase, uridine diphosphoglucose (Salmonella typhimurium clone pAGS5 gene ushB isoenzyme reduced), hydrolase, uridine diphosphoglucose (Salmonella typhimurium gene ushA0 isoenzyme precursor reduced), hydrolase, uridine diphosphoglucose (Salmonella typhimurium gene ushA0 isoenzyme reduced), nucleosidediphosphate-sugar diphosphatase, nucleosidediphosphate-sugar pyrophosphatase, Nudix hydrolase-like nucleotide hydrolase, toxin A, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
UDP-sugar + H2O = UMP + alpha-D-aldose 1-phosphate
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