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Information on EC 3.6.1.21 - ADP-sugar diphosphatase for references in articles please use BRENDA:EC3.6.1.21
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EC Tree
IUBMB Comments Has a specificity that is distinct from that of UDP-sugar diphosphatase (EC 3.6.1.45).
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
adenosine 5'-diphosphosugar pyrophosphatase, adenosine diphosphate sugar pyrophosphatase, adenosine diphosphate-glucose pyrophosphatase, adenosine diphosphosugar pyrophosphatase, ADP sugar pyrophosphatase, ADP-ribose pyrophosphatase, ADPsugar pyrophosphatase, AspP, ASPPase,
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adenosine 5'-diphosphosugar pyrophosphatase
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adenosine diphosphate sugar pyrophosphatase
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adenosine diphosphate-glucose pyrophosphatase
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adenosine diphosphosugar pyrophosphatase
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ADP sugar pyrophosphatase
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ADP-ribose pyrophosphatase
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ADPsugar pyrophosphatase
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ADP-sugar + H2O = AMP + alpha-D-aldose 1-phosphate
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phosphorous acid anhydride hydrolysis
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ADP-sugar sugarphosphohydrolase
Has a specificity that is distinct from that of UDP-sugar diphosphatase (EC 3.6.1.45).
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ADP-alpha-D-glucose + H2O
AMP + alpha-D-glucose 1-phosphate
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?
ADP-Glc + H2O
AMP + Glc-1-phosphate
ADP-glucose + H2O
AMP + alpha-D-glucose 1-phosphate
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?
ADP-Man + H2O
AMP + Man-1-phosphate
ADP-mannose + H2O
AMP + alpha-D-mannose 1-phosphate
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?
ADP-Rib + H2O
AMP + Rib-5-phosphate
ADP-ribose + H2O
AMP + alpha-D-ribose 1-phosphate
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?
ADP-sugar + H2O
AMP + sugar phosphate
GDP-Glc + H2O
GMP + Glc-1-phosphate
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very poor substrate
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?
GDP-Man + H2O
GMP + Man-1-phosphate
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very poor substrate
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?
additional information
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ADP-Glc + H2O
AMP + Glc-1-phosphate
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?
ADP-Glc + H2O
AMP + Glc-1-phosphate
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?
ADP-Glc + H2O
AMP + Glc-1-phosphate
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?
ADP-Man + H2O
AMP + Man-1-phosphate
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?
ADP-Man + H2O
AMP + Man-1-phosphate
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?
ADP-Man + H2O
AMP + Man-1-phosphate
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?
ADP-Rib + H2O
AMP + Rib-5-phosphate
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?
ADP-Rib + H2O
AMP + Rib-5-phosphate
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?
ADP-Rib + H2O
AMP + Rib-5-phosphate
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?
ADP-sugar + H2O
AMP + sugar phosphate
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?
ADP-sugar + H2O
AMP + sugar phosphate
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?
ADP-sugar + H2O
AMP + sugar phosphate
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?
ADP-sugar + H2O
AMP + sugar phosphate
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?
ADP-sugar + H2O
AMP + sugar phosphate
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?
ADP-sugar + H2O
AMP + sugar phosphate
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?
ADP-sugar + H2O
AMP + sugar phosphate
Salmonella weslaco
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?
FAD + H2O
AMP + FMN
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very poor substrate
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?
FAD + H2O
AMP + FMN
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very poor substrate
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?
FAD + H2O
AMP + FMN
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very poor substrate
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?
NAD+ + H2O
AMP + NMN
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very poor substrate
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?
NAD+ + H2O
AMP + NMN
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very poor substrate
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?
NAD+ + H2O
AMP + NMN
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very poor substrate
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additional information
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the enzyme may play a pivotal role in controlling the gluconeogenic process and in interconnecting gluconeogenesis with other metabolic pathways
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additional information
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no activity with UDPglucose, CDPglucose, GDPmannose, adenosine 5'-phosphosulfate, diphosphate, synthetic phosphodiester bonds containing compounds such as p-nitrophenylphosphate, sugar phosphates and nucleoside mono-, di- and triphosphates
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ADP-sugar + H2O
AMP + sugar phosphate
additional information
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the enzyme may play a pivotal role in controlling the gluconeogenic process and in interconnecting gluconeogenesis with other metabolic pathways
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ADP-sugar + H2O
AMP + sugar phosphate
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?
ADP-sugar + H2O
AMP + sugar phosphate
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?
ADP-sugar + H2O
AMP + sugar phosphate
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?
ADP-sugar + H2O
AMP + sugar phosphate
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?
ADP-sugar + H2O
AMP + sugar phosphate
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?
ADP-sugar + H2O
AMP + sugar phosphate
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?
ADP-sugar + H2O
AMP + sugar phosphate
Salmonella weslaco
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?
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Mg2+
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divalent cation required for full activity, Mg2+ at concentration of 0.4 mM most effective
Mg2+
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divalent cation required for full activity, Mg2+ at concentration of 0.4 mM most effective
Mg2+
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divalent cation required for full activity, Mg2+ at concentration of 0.4 mM most effective
Mg2+
Salmonella weslaco
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3-Phosphoglyceric acid
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intracellular inhibitor
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additional information
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no substantial inhibition by orthophosphate
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ADP
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Ki: 0.075 mM
ATP
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Ki: 0.165 mM
intracellular inhibitor
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can be destroyed by heating up to 58°C for a few min, inhibitor is resistant towards RNAse and DNAse and detectable at 280 nm
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intracellular inhibitor
Salmonella weslaco
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can be destroyed by heating up to 58°C for a few min, inhibitor is resistant towards RNAse and DNAse and detectable at 280 nm
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D-glucose-1,6-bisphosphate
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AspP activity is strongly enhanced by D-glucose-1,6-bisphosphate
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0.167
ADP-glucose
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pH 7.5
0.183
ADP-mannose
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pH 7.5
0.125
ADP-ribose
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pH 7.5
40
GDP-Glc
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same Km for GDP-Glc and GDP-Man
40
GDP-Man
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same Km for GDP-Glc and GDP-Man
0.29
ADP-Glc
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1.3
ADP-Rib
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0.7
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ADP-Glc with partially purified enzyme
6.6 - 7.2
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ADP-Glc as substrate
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7 - 8
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7 - 8
Salmonella weslaco
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7.8 - 8.4
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with ADP-Glc as substrate
7.8 - 8.4
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with ADP-Glc as substrate
7.8 - 8.4
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with ADP-Glc as substrate
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5
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no activity even in presence of Mg2+ or Co2+
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58
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activation of the enzyme by inactivating an intracellular inhibitor
58
Salmonella weslaco
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activation of the enzyme by inactivating an intracellular inhibitor
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brenda
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brenda
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brenda
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brenda
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Salmonella weslaco
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brenda
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brenda
strain ATCC 12793
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brenda
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brenda
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brenda
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AspP binds to cell membranes as the bacterial population density increases, 30% of the total enzyme remaining membrane associated as glycogen depletes during the stationary phase, binding of AspP to the cell membrane is not dependent on quorum-sensing autoinducer 2 or glucose availability
brenda
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brenda
Salmonella weslaco
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brenda
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brenda
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brenda
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NUD14_ARATH
309
0
34254
Swiss-Prot
G7JK61_MEDTR
307
0
33572
TrEMBL
A0A2P6PPB8_ROSCH
294
0
32235
TrEMBL
A0A2P6QTV1_ROSCH
225
0
24499
TrEMBL
A0A2P6P7K9_ROSCH
298
0
33015
TrEMBL
Q88DA8_PSEPK
Pseudomonas putida (strain ATCC 47054 / DSM 6125 / NCIMB 11950 / KT2440)
209
0
23607
TrEMBL
A0A2P6PPD5_ROSCH
294
0
32278
TrEMBL
Q0VZ62_SOLTU
307
0
33577
TrEMBL
A0A2P6SQA5_ROSCH
241
0
26254
TrEMBL
E3TG37_ICTPU
216
0
24050
TrEMBL
A0A2P6QZ36_ROSCH
219
0
24384
TrEMBL
A0A2G9GZM3_9LAMI
333
0
36655
TrEMBL
A0A1D7ZYF3_LACFE
184
0
20334
TrEMBL
Q88R74_PSEPK
Pseudomonas putida (strain ATCC 47054 / DSM 6125 / NCIMB 11950 / KT2440)
188
0
20947
TrEMBL
A0A2G9HX05_9LAMI
333
0
36642
TrEMBL
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26000
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2 * 26000, SDS-PAGE
40000 - 50000
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gel filtration
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dimer
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2 * 26000, SDS-PAGE
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partial purification together with UDP-sugar pyrophosphatase
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partial
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Providenzia, R.; Bass, S.T.; Hansen, R.G.
A pyrophosphatase from mammalian tissues specific for derivatives of ADP
Biochim. Biophys. Acta
167
199-201
1968
Bos taurus, Oryctolagus cuniculus, Rattus norvegicus
brenda
Glaser, L.; Melo, A.; Paul, R.
Uridine diphosphate sugar hydrolase. Purification of enzyme and protein inhibitor
J. Biol. Chem.
242
1944-1954
1967
Escherichia coli, Salmonella enterica subsp. enterica serovar Typhimurium
brenda
Melo, A.; Glaser, L.
Nucleotide diphosphate hexose pyrophosphatases
Biochem. Biophys. Res. Commun.
22
524-531
1966
Escherichia coli, Salmonella weslaco
brenda
Moreno-Bruna, B.; Baroja-Fernandez, E.; Munoz, F.J.; Bastarrica-Berasategui, A.; Zandueta-Criado, A.; Rodriguez-Lopez, M.; Lasa, I.; Akazawa, T.; Pozueta-Romero, J.
Adenosine diphosphate sugar pyrophosphatase prevents glycogen biosynthesis in Escherichia coli
Proc. Natl. Acad. Sci. USA
98
8128-8132
2001
Escherichia coli
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Moran-Zorzano, M.T.; Montero, M.; Munoz, F.J.; Alonso-Casajus, N.; Viale, A.M.; Eydallin, G.; Sesma, M.T.; Baroja-Fernandez, E.; Pozueta-Romero, J.
Cytoplasmic Escherichia coli ADP sugar pyrophosphatase binds to cell membranes in response to extracellular signals as the cell population density increases
FEMS Microbiol. Lett.
288
25-32
2008
Escherichia coli BL21(DE3)
brenda
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3.6.1.21 ADP-sugar diphosphatase
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