Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

BRENDA Home
show all | hide all No of entries

Information on EC 3.6.1.19 - nucleoside-triphosphate diphosphatase and Organism(s) Homo sapiens and UniProt Accession Q9BY32

for references in articles please use BRENDA:EC3.6.1.19
deleted, now included with EC 3.6.1.9
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
kcat/KM VALUE [1/mMs-1]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
94
5-methyl-CTP
-
wild type enzyme, at 37°C, pH not specified in the publication
93
5-methyl-UTP
-
wild type enzyme, at 37°C, pH not specified in the publication
19
8-oxo-GTP
-
wild type enzyme, at 37°C, pH not specified in the publication
46
CTP
-
wild type enzyme, at 37°C, pH not specified in the publication
13
dCTP
-
wild type enzyme, at 37°C, pH not specified in the publication
21 - 58
dTTP
130
pseudo-UTP
-
wild type enzyme, at 37°C, pH not specified in the publication
17
UTP
-
wild type enzyme, at 37°C, pH not specified in the publication
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
-
enzyme knockdown sensitizes HeLa cells to 6-N-hydroxylaminopurine-induced DNA breaks and apoptosis, and results in elevated mutagenesis in response to 6-N-hydroxylaminopurine treatment. Individuals with defective ITPase are predisposed to genome damage by impurities in nucleotide pools. They are also at an elevated risk for degenerative diseases and cancer
physiological function
-
the enzyme prevents 6-N hydroxylaminopurine-induced apoptosis, DNA damage and mutagenesis in human cells
physiological function
-
upon combined expression of human ecto-5'-nucleotidase and ecto-nucleoside triphosphate diphosphohydrolase 1 in pig endothelial cells using F2A sequence bearing construct, addition of AMP increases production of adenosine in the medium to 14.2 microM while it remains below 1 microM in controls. A marked increase of adenosine formation from ADP or ATP is observed only in cells transfected with both enzymes