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Disease on EC 3.6.1.15 - nucleoside-triphosphate phosphatase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Adenomyosis
Characterization of the Endometrial MSC Marker Ectonucleoside Triphosphate Diphosphohydrolase-2 (NTPDase2/CD39L1) in Low- and High-Grade Endometrial Carcinomas: Loss of Stromal Expression in the Invasive Phenotypes.
The ectonucleoside triphosphate diphosphohydrolase-2 (NTPDase2) in human endometrium: a novel marker of basal stroma and mesenchymal stem cells.
African Horse Sickness
Genome segment reassortment identifies non-structural protein NS3 as a key protein in African horsesickness virus release and alteration of membrane permeability.
[Use of the immunoenzyme test ELISA-NS3 to distinguish horses infected by African horsesickness virus from vaccinated horses]
African Swine Fever
Nucleoside triphosphate phosphohydrolase activities in African swine fever virus.
Nucleotide sequence of a nucleoside triphosphate phosphohydrolase gene from African swine fever virus.
Alzheimer Disease
Kidins220 accumulates with tau in human Alzheimer's disease and related models: modulation of its calpain-processing by GSK3?/PP1 imbalance.
Arthritis, Rheumatoid
Activities of enzymes that hydrolyze adenine nucleotides in platelets from patients with rheumatoid arthritis.
Synovial fluid pyrophosphate and nucleoside triphosphate pyrophosphatase: comparison between normal and diseased and between inflamed and non-inflamed joints.
Asthma
Blockade of ankyrin repeat-rich membrane spanning protein modulates extracellular signal-regulated kinase expression and inhibits allergic inflammation in ovalbumin-sensitized mice.
Astrocytoma
Isolation and characterization of plasma membranes from transplantable human astrocytoma, oat cell carcinoma, and melanomas.
Azoospermia
Mutations in the testis-specific NALP14 gene in men suffering from spermatogenic failure.
Bluetongue
Bluetongue virus core protein VP4 has nucleoside triphosphate phosphohydrolase activity.
Bluetongue virus VP6 acts early in the replication cycle and can form the basis of chimeric virus formation.
Defining the structure-function relationships of bluetongue virus helicase protein VP6.
High level expression of the major core protein VP7 and the non-structural protein NS3 of bluetongue virus in yeast: use of expressed VP7 as a diagnostic, group-reactive antigen in a blocking ELISA.
Localization of the non-structural protein NS3 in bluetongue virus-infected cells.
The membrane trafficking protein calpactin forms a complex with bluetongue virus protein NS3 and mediates virus release.
Brain Injuries
Biochemical brain markers and purinergic parameters in rat CSF after seizure induced by pentylenetetrazol.
Brain Ischemia
Nuclear-envelope nucleoside triphosphatase kinetics and mRNA transport following brain ischemia and reperfusion.
Breast Neoplasms
Enzymes that hydrolyze adenine nucleotides in platelets from breast cancer patients.
Carcinogenesis
Hepatitis C virus NS3 protein enhances hepatocellular carcinoma cell invasion by promoting PPM1A ubiquitination and degradation.
Kidins220 and tumour development: Insights into a complexity of cross-talk among signalling pathways (Review).
NMR structure and functional characterization of a human cancer-related nucleoside triphosphatase.
Reduced kinase D?interacting substrate of 220 kDa (Kidins220) in pancreatic cancer promotes EGFR/ERK signalling and disease progression.
Carcinoma
Arabinosyl-5-azacytosine: mechanisms of native and acquired resistance.
Isolation and characterization of plasma membranes from transplantable human astrocytoma, oat cell carcinoma, and melanomas.
Carcinoma, Hepatocellular
Cell-type specificity of ectonucleotidase expression and upregulation by 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Hepatitis C virus NS3 protein enhances hepatocellular carcinoma cell invasion by promoting PPM1A ubiquitination and degradation.
Carcinoma, Small Cell
Isolation and characterization of plasma membranes from transplantable human astrocytoma, oat cell carcinoma, and melanomas.
Cardiovascular Abnormalities
Kidins220 and tumour development: Insights into a complexity of cross-talk among signalling pathways (Review).
Kidins220/ARMS mediates the integration of the neurotrophin and VEGF pathways in the vascular and nervous systems.
Cardiovascular Diseases
Expression of NTPDase1 and caveolins in human cardiovascular disease.
Cholestasis
Portal fibroblasts regulate the proliferation of bile duct epithelia via expression of NTPDase2.
Classical Swine Fever
Characterization of classical swine fever virus (CSFV) nonstructural protein 3 (NS3) helicase activity and its modulation by CSFV RNA-dependent RNA polymerase.
Cytopathic effect of classical swine fever virus NS3 protein on PK-15 cells.
Identification and characterization of the NTPase activity of classical swine fever virus (CSFV) nonstructural protein 3 (NS3) expressed in bacteria.
Identification of an NTPase motif in classical swine fever virus NS4B protein.
Colitis
Expression of Ecto-nucleoside Triphosphate Diphosphohydrolases-2 and -3 in the Enteric Nervous System Affects Inflammation in Experimental Colitis and Crohn's Disease.
NTPDase1 and -2 are expressed by distinct cellular compartments in the mouse colon and differentially impact colonic physiology and function after DSS colitis.
Contracture
Homozygous KIDINS220 loss-of-function variants in fetuses with cerebral ventriculomegaly and limb contractures.
Prenatal delineation of a distinct lethal fetal syndrome caused by a homozygous truncating KIDINS220 variant.
TrkA mediates effect of novel KIDINS220 mutation in human brain ventriculomegaly.
Coronavirus Infections
Coronavirus infection induces DNA replication stress partly through interaction of its nonstructural protein 13 with the p125 subunit of DNA polymerase ?.
COVID-19
Analysis and comparison of genetic variants and mutations of the novel coronavirus SARS-CoV-2.
Discovering potential inhibitors against SARS-CoV-2 by targeting Nsp13 Helicase.
Discovery of COVID-19 Inhibitors Targeting the SARS-CoV-2 Nsp13 Helicase.
Discovery of COVID-19 Inhibitors Targeting the SARS-CoV2 Nsp13 Helicase.
Genomic discovery of an evolutionarily programmed modality for small-molecule targeting of an intractable protein surface.
SARS-CoV-2-specific T cell immunity in cases of COVID-19 and SARS, and uninfected controls.
Should We Try SARS-CoV-2 Helicase Inhibitors for COVID-19 Therapy?
Structural basis for helicase-polymerase coupling in the SARS-CoV-2 replication-transcription complex.
Structural Basis for Helicase-Polymerase Coupling in the SARS-CoV-2 Replication-Transcription Complex.
Crohn Disease
Expression of Ecto-nucleoside Triphosphate Diphosphohydrolases-2 and -3 in the Enteric Nervous System Affects Inflammation in Experimental Colitis and Crohn's Disease.
Cystic Fibrosis
CYSTIC FIBROSIS REMODELS THE REGULATION OF PURINERGIC SIGNALING BY NTPDASE1 (CD39) AND NTPDASE3.
Cysts
Detection of nucleoside triphosphate hydrolase as a circulating antigen in sera of mice infected with Toxoplasma gondii.
Kinetics of the nucleoside triphosphate hydrolase of Toxoplasma gondii in mice with acute and chronic toxoplasmosis.
Dementia
Kidins220 accumulates with tau in human Alzheimer's disease and related models: modulation of its calpain-processing by GSK3?/PP1 imbalance.
Demyelinating Diseases
Activities of enzymes that hydrolyze adenine nucleotides in platelets from rats experimentally demyelinated with ethidium bromide and treated with interferon-beta.
Effect of vitamin E on ectonucleotidase activities in synaptosomes and platelets and parameters of oxidative stress in rats experimentally demyelinated.
Dengue
Allostery in the dengue virus NS3 helicase: Insights into the NTPase cycle from molecular simulations.
Analysis of the nucleoside triphosphatase, RNA triphosphatase, and unwinding activities of the helicase domain of dengue virus NS3 protein.
Differential humoral and cellular immunity induced by vaccination using plasmid DNA and protein recombinant expressing the NS3 protein of dengue virus type 3.
Induction of a protective response in mice by the dengue virus NS3 protein using DNA vaccines.
Modulation of enzymatic activity of dengue virus nonstructural protein NS3 nucleoside triphosphatase/helicase by poly(U).
Mutagenesis of the Dengue virus type 2 NS3 protein within and outside helicase motifs: effects on enzyme activity and virus replication.
Passive protection studies in mice with monoclonal antibodies directed against the non-structural protein NS3 of dengue 1 virus.
Recombinant dengue virus type 1 NS3 protein exhibits specific viral RNA binding and NTPase activity regulated by the NS5 protein.
Steady-State NTPase Activity of Dengue Virus NS3: Number of Catalytic Sites, Nucleotide Specificity and Activation by ssRNA.
Structural proteomics of dengue virus.
Structure of the Dengue virus helicase/nucleoside triphosphatase catalytic domain at a resolution of 2.4 A.
Synthesis and evaluation of ATP-binding site directed potential inhibitors of nucleoside triphosphatases/helicases and polymerases of hepatitis C and other selected Flaviviridae viruses.
The RNA helicase, nucleotide 5'-triphosphatase, and RNA 5'-triphosphatase activities of Dengue virus protein NS3 are Mg2+-dependent and require a functional Walker B motif in the helicase catalytic core.
The serine protease and RNA-stimulated nucleoside triphosphatase and RNA helicase functional domains of dengue virus type 2 NS3 converge within a region of 20 amino acids.
The two-component NS2B-NS3 proteinase represses DNA unwinding activity of the West Nile virus NS3 helicase.
Dermatitis, Contact
Enhancement of Anti-Dermatitis Potential of Clobetasol Propionate by DHA [Docosahexaenoic Acid] Rich Algal Oil Nanoemulsion Gel.
Improved efficacy in the treatment of contact dermatitis in rats by a dermatological nanomedicine containing clobetasol propionate.
Nanoencapsulation of Clobetasol Propionate Decreases Its Penetration to Skin Layers Without Changing Its Relative Skin Distribution.
Diabetes Mellitus
Enhanced NTPDase and 5'-nucleotidase activities in diabetes mellitus and iron-overload model.
Diabetes Mellitus, Type 2
Enzymes that hydrolyze adenine nucleotides in diabetes and associated pathologies.
Encephalitis, Japanese
Characterization of the NTPase activity of Japanese encephalitis virus NS3 protein.
Halogenated benzimidazoles and benzotriazoles as inhibitors of the NTPase/helicase activities of hepatitis C and related viruses.
Inhibitors of the NTPase/helicases of hepatitis C and related Flaviviridae viruses.
Japanese encephalitis virus nonstructural protein NS3 has RNA binding and ATPase activities.
Synthesis and evaluation of ATP-binding site directed potential inhibitors of nucleoside triphosphatases/helicases and polymerases of hepatitis C and other selected Flaviviridae viruses.
Viral NS3 helicase activity is inhibited by peptides reproducing the Arg-rich conserved motif of the enzyme (motif VI).
Encephalomyelitis
Down-regulation of NTPDase2 and ADP-sensitive P2 Purinoceptors Correlate with Severity of Symptoms during Experimental Autoimmune Encephalomyelitis.
Encephalomyelitis, Autoimmune, Experimental
Down-regulation of NTPDase2 and ADP-sensitive P2 Purinoceptors Correlate with Severity of Symptoms during Experimental Autoimmune Encephalomyelitis.
Encephalomyelitis, Western Equine
Nucleoside triphosphate phosphohydrolase produced in BHK cells infected with western equine encephalitis virus is probably associated with the 82K dalton nonstructural polypeptide.
Endometrial Neoplasms
Characterization of the Endometrial MSC Marker Ectonucleoside Triphosphate Diphosphohydrolase-2 (NTPDase2/CD39L1) in Low- and High-Grade Endometrial Carcinomas: Loss of Stromal Expression in the Invasive Phenotypes.
Epilepsy
A ketogenic diet did not prevent effects on the ectonucleotidases pathway promoted by lithium-pilocarpine-induced status epilepticus in rat hippocampus.
Foot-and-Mouth Disease
Expression of tuberculosis antigen ESAT-6 in Nicotiana tabacum using a potato virus X-based vector.
Genetic engineering and chemical conjugation of potato virus X.
Fowlpox
Nucleotide sequence of a nucleoside triphosphate phosphohydrolase gene from African swine fever virus.
Glioma
In vivo glioblastoma growth is reduced by apyrase activity in a rat glioma model.
Overexpression of NTPDase2 in gliomas promotes systemic inflammation and pulmonary injury.
Selective NTPDase2 expression modulates in vivo rat glioma growth.
Hepatitis
Murine coronaviruses encoding nsp2 at different genomic loci have altered replication, protein expression, and localization.
Hepatitis A
Membrane association and RNA binding of recombinant hepatitis A virus protein 2C.
Hepatitis C
5'-O-fluorosulfonylbenzoyl esters of purine nucleosides as potential inhibitors of NTPase/helicase and polymerase of Flaviviridae viruses.
A point mutation abolishes the helicase but not the nucleoside triphosphatase activity of hepatitis C virus NS3 protein.
A steady-state and pre-steady-state kinetic analysis of the NTPase activity associated with the hepatitis C virus NS3 helicase domain.
Activity of purified hepatitis C virus protease NS3 on peptide substrates.
ATP-binding domain of NTPase/helicase as a target for hepatitis C antiviral therapy.
Backbone 1H, 15N and 13C resonance assignments of the NTPase subdomain of the hepatitis C virus NS3 RNA helicase.
Biochemical properties of a minimal functional domain with ATP-binding activity of the NTPase/helicase of hepatitis C virus.
BIOFILTER AS A FUNCTIONAL ANNOTATION PIPELINE FOR COMMON AND RARE COPY NUMBER BURDEN.
Characterization and mutational analysis of the helicase and NTPase activities of hepatitis C virus full-length NS3 protein.
Characterization of a monoclonal antibody and its single-chain antibody fragment recognizing the nucleoside Triphosphatase/Helicase domain of the hepatitis C virus nonstructural 3 protein.
Characterization of imidazo[4,5-d]pyridazine nucleosides as modulators of unwinding reaction mediated by West Nile virus nucleoside triphosphatase/helicase: evidence for activity on the level of substrate and/or enzyme.
Characterization of RNA binding activity and RNA helicase activity of the hepatitis C virus NS3 protein.
Crystal structure of the ATPase domain of translation initiation factor 4A from Saccharomyces cerevisiae--the prototype of the DEAD box protein family.
Design, high-level expression, purification and characterization of soluble fragments of the hepatitis C virus NS3 RNA helicase suitable for NMR-based drug discovery methods and mechanistic studies.
Direct fluorometric measurement of hepatitis C virus helicase activity.
Ectonucleotidase NTPDase2 is selectively down-regulated in biliary cirrhosis.
Enzymatic characterization of hepatitis C virus NS3/4A complexes expressed in mammalian cells by using the herpes simplex virus amplicon system.
Enzymatic properties of hepatitis C virus NS3-associated helicase.
Functional interactions between conserved motifs of the hepatitis C virus RNA helicase protein NS3.
Halogenated benzimidazoles and benzotriazoles as inhibitors of the NTPase/helicase activities of hepatitis C and related viruses.
Hepatitis C viral NS3-4A protease activity is enhanced by the NS3 helicase.
Hepatitis C virus helicase/NTPase: an efficient expression system and new inhibitors.
Hepatitis C virus non-structural protein NS3 interacts with LMP7, a component of the immunoproteasome, and affects its proteasome activity.
Hepatitis C virus NS3 NTPase/helicase: different stereoselectivity in nucleoside triphosphate utilisation suggests that NTPase and helicase activities are coupled by a nucleotide-dependent rate limiting step.
Hepatitis C virus NS3 protein polynucleotide-stimulated nucleoside triphosphatase and comparison with the related pestivirus and flavivirus enzymes.
Humoral and CD4(+) T helper (Th) cell responses to the hepatitis C virus non-structural 3 (NS3) protein: NS3 primes Th1-like responses more effectively as a DNA-based immunogen than as a recombinant protein.
Identification and characterization of the NTPase activity of classical swine fever virus (CSFV) nonstructural protein 3 (NS3) expressed in bacteria.
Identification of myricetin and scutellarein as novel chemical inhibitors of the SARS coronavirus helicase, nsP13.
In vitro cleavage of hepatitis C virus polyprotein substrates by purified recombinant NS3 protease.
In vivo attenuation of recombinant murine gammaherpesvirus 68 (MHV-68) is due to the expression and immunogenicity but not to the insertion of foreign sequences.
Inhibition of hepatitis C virus nonstructural protein, helicase activity, and viral replication by a recombinant human antibody clone.
Inhibition of the helicase activity of HCV NTPase/helicase by 1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide-5 '-triphosphate (ribavirin-TP).
Inhibitors of the NTPase/helicases of hepatitis C and related Flaviviridae viruses.
Internal cleavage of hepatitis C virus NS3 protein is dependent on the activity of NS34A protease.
Isolation of specific and high-affinity RNA aptamers against NS3 helicase domain of hepatitis C virus.
Modulation of hepatitis C virus NS3 protease and helicase activities through the interaction with NS4A.
Multiple enzymatic activities associated with recombinant NS3 protein of hepatitis C virus.
Non-structural protein 3 of hepatitis C virus inhibits phosphorylation mediated by cAMP-dependent protein kinase.
Nucleotide triphosphatase/helicase of hepatitis C virus as a target for antiviral therapy.
Of minibody, camel and bacteriophage.
Polynucleotide modulation of the protease, nucleoside triphosphatase, and helicase activities of a hepatitis C virus NS3-NS4A complex isolated from transfected COS cells.
Proteolytic activity of NS3 serine proteinase of hepatitis C virus efficiently expressed in Escherichia coli.
Roles of the AX(4)GKS and arginine-rich motifs of hepatitis C virus RNA helicase in ATP- and viral RNA-binding activity.
Significance of monoclonal antibodies against the conserved epitopes within non-structural protein 3 helicase of hepatitis C virus.
Structure of the hepatitis C virus RNA helicase domain.
Synthesis and evaluation of ATP-binding site directed potential inhibitors of nucleoside triphosphatases/helicases and polymerases of hepatitis C and other selected Flaviviridae viruses.
The hepatitis C virus protein NS3 suppresses TNF-?-stimulated activation of NF-?B by targeting LUBAC.
The NTPase/helicase domain of hepatitis C virus nonstructural protein 3 inhibits protein kinase C independently of its NTPase activity.
Towards defining a minimal functional domain for NTPase and RNA helicase activities of the hepatitis C virus NS3 protein.
Viral NS3 helicase activity is inhibited by peptides reproducing the Arg-rich conserved motif of the enzyme (motif VI).
Zika virus NS4A N-Terminal region (1-48) acts as a cofactor for inducing NTPase activity of NS3 helicase but not NS3 protease.
[Impact of the heterogenicity of amino acid sequence on the immunoreactivity of an antigenic epitopic complex localized within amino acids 1192-1456 of protein NS3 protein of hepatitis C virus]
[The combined application of nucleotide and amino acid sequences of NS3 hepatitis C virus protein, DNA encoding granulocyte macrophage colony-stimulating factor and inhibitor of regulatory T cells induces effective immune response against hepatitis C virus].
Hepatitis E
NTPase and 5' to 3' RNA duplex-unwinding activities of the hepatitis E virus helicase domain.
Herpes Simplex
Interactions of a subassembly of the herpes simplex virus type 1 helicase-primase with DNA.
The herpes simplex virus type 1 origin-binding protein carries out origin specific DNA unwinding and forms stem-loop structures.
The herpes simplex virus type I origin binding protein. DNA-dependent nucleoside triphosphatase activity.
HIV Infections
HIV infection is associated with increased NTPDase activity that correlates with CD39-positive lymphocytes.
Huntington Disease
Differential regulation of Kidins220 isoforms in Huntington's disease.
Hydrocephalus
Homozygous KIDINS220 loss-of-function variants in fetuses with cerebral ventriculomegaly and limb contractures.
Kidins220 deficiency causes ventriculomegaly via SNX27-retromer-dependent AQP4 degradation.
Hydrocephalus, Normal Pressure
Kidins220 deficiency causes ventriculomegaly via SNX27-retromer-dependent AQP4 degradation.
Hyperargininemia
NTPDase and 5'-nucleotidase activities of synaptosomes from hippocampus of rats subjected to hyperargininemia.
Hypercholesterolemia
Enzymes that hydrolyze adenine nucleotides in a model of hypercholesterolemia induced by Triton WR-1339: protective effects of ?-caryophyllene.
Nuclear cholesterol content and nucleoside triphosphatase activity are altered in the JCR:LA-cp corpulent rat.
Hyperlipidemias
Nuclear cholesterol content and nucleoside triphosphatase activity are altered in the JCR:LA-cp corpulent rat.
Hypertension
Enzymes that hydrolyze adenine nucleotides in diabetes and associated pathologies.
Hyperthyroidism
Hypo-and hyperthyroidism affect the ATP, ADP and AMP hydrolysis in rat hippocampal and cortical slices.
Hypertriglyceridemia
Nuclear cholesterol content and nucleoside triphosphatase activity are altered in the JCR:LA-cp corpulent rat.
Hypothyroidism
Genomic-independent action of thyroid hormones on NTPDase activities in Sertoli cell cultures from congenital hypothyroid rats.
Hypo-and hyperthyroidism affect the ATP, ADP and AMP hydrolysis in rat hippocampal and cortical slices.
Hypothyroidism Enhanced Ectonucleotidases and Acetylcholinesterase Activities in Rat Synaptosomes can be Prevented by the Naturally Occurring Polyphenol Quercetin.
Quercetin changes purinergic enzyme activities and oxidative profile in platelets of rats with hypothyroidism.
hypoxanthine phosphoribosyltransferase deficiency
Altered membrane NTPase activity in Lesch-Nyhan disease fibroblasts: comparison with HPRT knockout mice and HPRT-deficient cell lines.
Complex changes in ecto-nucleoside 5'-triphosphate diphosphohydrolase expression in hypoxanthine phosphoribosyl transferase deficiency.
Infections
Analysis of the mechanism of protection in transgenic plants expressing the potato virus X coat protein or its antisense RNA.
CD39 modulates IL-1 release from activated endothelial cells.
Cell-to-cell and phloem-mediated transport of potato virus X. The role of virions
Curcumin pre-treatment modulate the activities of adenine nucleotide and nucleoside degradation enzymes in lymphocyte of rats infected with Trypanosoma evansi.
Ectonucleotidases and adenosine deaminase activity in laying hens naturally infected by Salmonella Gallinarum and their effects on the pathogenesis of the disease.
Enzymatic properties of an ecto-nucleoside triphosphate diphosphohydrolase from Legionella pneumophila: substrate specificity and requirement for virulence.
Expression of Amino-Terminal Portions or Full-Length Viral Replicase Genes in Transgenic Plants Confers Resistance to Potato Virus X Infection.
Expression of the PVY(O) coat protein (CP) under the control of the PVX CP gene leader sequence: protection under greenhouse and field conditions against PVT(O) and PVY(N) infection in three potato cultivars.
Functional cross-talk between distant domains of chikungunya virus non-structural protein 2 is decisive for its RNA-modulating activity.
Generation and Characterization of Monoclonal Antibody Against Porcine Epidemic Diarrhea Virus Nonstructural Protein 13.
Genome segment reassortment identifies non-structural protein NS3 as a key protein in African horsesickness virus release and alteration of membrane permeability.
Identification of new potent inhibitors of dengue virus NS3 protease from traditional Chinese medicine database.
Immobilization of NTPDase-1 from Trypanosoma cruzi and Development of an Online Label-Free Assay.
Impacts of Escherichia coli infection in young breeder chicks on the animal behavior and cerebral activity of purinergic and cholinergic enzymes involved in the regulation of molecules with neurotransmitter and neuromodulator function.
Influence of experimental Anaplasma marginale infection and splenectomy on NTPDase and 5'nucleotidase activities in platelets of cattle.
Koala and wombat gammaherpesviruses encode the first known viral nucleoside triphosphate diphosphohydrolase (NTPDase) homologs and are phylogenetically divergent from all known gammaherpesviruses.
Melaleuca alternifolia essential oil prevents alterations to purinergic enzymes and ameliorates the innate immune response in silver catfish infected with Aeromonas hydrophila.
N-Naphthoyl-substituted indole thio-barbituric acid analogs inhibit the helicase activity of the hepatitis C virus NS3.
Neuroprotective role of resveratrol mediated by purinergic signalling in cerebral cortex of mice infected by Toxoplasma gondii.
NTPDase activity in lymphocytes of rats infected by Trypanosoma evansi.
NTPDase Specific Inhibitors Suppress Rice Infection by Magnaporthe oryzae
Seric and hepatic NTPDase and 5' nucleotidase activities of rats experimentally infected by Fasciola hepatica.
The hepatitis C virus protein NS3 suppresses TNF-?-stimulated activation of NF-?B by targeting LUBAC.
The reovirus ?2 C-terminal loop inversely regulates NTPase and transcription functions versus binding to factory-forming ?NS and promotes replication in tumorigenic cells.
Tobacco mosaic virus (TMV) and potato virus X (PVX) coat proteins confer heterologous interference to PVX and TMV infection, respectively.
Toxoplasmosis treatment with diphenyl diselenide in infected mice modulates the activity of purinergic enzymes and reduces inflammation in spleen.
Influenza, Human
Adaptive mutation in influenza A virus non-structural gene is linked to host switching and induces a novel protein by alternative splicing.
Immunogenic compositions assembled from tobacco mosaic virus-generated spherical particle platforms and foreign antigens.
Intellectual Disability
Atypical, milder presentation in a child with CC2D2A and KIDINS220 variants.
Genetic and Clinical Profile of Chinese Patients with Autosomal Dominant Spastic Paraplegia.
Homozygous KIDINS220 loss-of-function variants in fetuses with cerebral ventriculomegaly and limb contractures.
Prenatal delineation of a distinct lethal fetal syndrome caused by a homozygous truncating KIDINS220 variant.
Joint Diseases
Synovial fluid pyrophosphate and nucleoside triphosphate pyrophosphatase: comparison between normal and diseased and between inflamed and non-inflamed joints.
Kidney Failure, Chronic
Enzymes that hydrolyze adenine nucleotides in chronic renal failure: relationship between hemostatic defects and renal failure severity.
Leishmaniasis
Label-free assay based on immobilized capillary enzyme reactor of Leishmania infantum nucleoside triphosphate diphosphohydrolase (LicNTPDase-2-ICER-LC/UV).
NTPDase activities: possible roles on Leishmania spp infectivity and virulence.
Leishmaniasis, Visceral
An antigenic domain within a catalytically active Leishmania infantum nucleoside triphosphate diphosphohydrolase (NTPDase 1) is a target of inhibitory antibodies.
Leishmania infantum nucleoside triphosphate diphosphohydrolase 1 (NTPDase 1) B-domain: Antibody antiproliferative effect on the promastigotes and IgG subclass responses in canine visceral leishmaniasis.
Lesch-Nyhan Syndrome
Altered membrane NTPase activity in Lesch-Nyhan disease fibroblasts: comparison with HPRT knockout mice and HPRT-deficient cell lines.
Liver Cirrhosis
Ecto-Nucleotide Triphosphate Diphosphohydrolase-2 (NTPDase2) Deletion Increases Acetaminophen-Induced Hepatotoxicity.
Liver Cirrhosis, Biliary
Ectonucleotidase NTPDase2 is selectively down-regulated in biliary cirrhosis.
IL-6 downregulates transcription of NTPDase2 via specific promoter elements.
Liver Diseases
Ectonucleotidase NTPDase2 is selectively down-regulated in biliary cirrhosis.
Lung Injury
Overexpression of NTPDase2 in gliomas promotes systemic inflammation and pulmonary injury.
Lung Neoplasms
Lung cancer alters the hydrolysis of nucleotides and nucleosides in platelets.
Lupus Erythematosus, Systemic
ATP signaling and NTPDase in Systemic Lupus Erythematosus (SLE).
Lymphoma
Energy requirement and kinetics of transport of poly(A)-free histone mRNA compared to poly(A)-rich mRNA from isolated L-cell nuclei.
Malaria
Functional genetic evaluation of DNA house-cleaning enzymes in the malaria parasite: dUTPase and Ap4AH are essential in Plasmodium berghei but ITPase and NDH are dispensable.
Melanoma
1?, 25-Dihydroxyvitamin D3 alters ectonucleotidase expression and activity in human cutaneous melanoma cells.
Effect of dexamethasone on nuclear envelope nucleoside triphosphatase in fibroblasts 3T3 and melanoma cells MMLI.
Isolation and characterization of plasma membranes from transplantable human astrocytoma, oat cell carcinoma, and melanomas.
Purification and properties of a nucleoside triphosphatase from Sinclair swine.
Upregulated ankyrin repeat-rich membrane spanning protein contributes to tumour progression in cutaneous melanoma.
Memory Disorders
Memory deficit, toxic effects and activity of Na(+), K(+)-ATPase and NTPDase in brain of Wistar rats submitted to orally treatment with alpha-terpinene.
Mouth Diseases
Expression of tuberculosis antigen ESAT-6 in Nicotiana tabacum using a potato virus X-based vector.
Genetic engineering and chemical conjugation of potato virus X.
Multiple Sclerosis
The activity and expression of NTPDase is altered in lymphocytes of multiple sclerosis patients.
Myocardial Ischemia
Metabolic control of excessive extracellular nucleotide accumulation by CD39/ecto-nucleotidase-1: implications for ischemic vascular diseases.
Neoplasm Metastasis
Reduced kinase D?interacting substrate of 220 kDa (Kidins220) in pancreatic cancer promotes EGFR/ERK signalling and disease progression.
The role of NK cells and CD39 in the immunological control of tumor metastases.
Neoplasms
2-hexylthio-?,?-CH2-ATP is an effective and selective NTPDase2 inhibitor.
8-BuS-ATP derivatives as specific NTPDase1 inhibitors.
An RNA-dependent nucleoside triphosphate hydrolase from Krebs-II ascites tumor cells. Detection and preliminary characterization.
CD39/ENTPD1 expression by CD4+Foxp3+ regulatory T cells promotes hepatic metastatic tumor growth in mice.
Characterization of the Endometrial MSC Marker Ectonucleoside Triphosphate Diphosphohydrolase-2 (NTPDase2/CD39L1) in Low- and High-Grade Endometrial Carcinomas: Loss of Stromal Expression in the Invasive Phenotypes.
Co-delivery of miR-4638-5p and docetaxel based on redox-sensitive polypeptide micelles as an improved strategy for the treatment of castration-resistant prostate cancer.
Development of Anthraquinone Derivatives as Ectonucleoside Triphosphate Diphosphohydrolase (NTPDase) Inhibitors With Selectivity for NTPDase2 and NTPDase3.
Functional dissection of nuclear envelope mRNA translocation system: effects of phorbol ester and a monoclonal antibody recognizing cytoskeletal structures.
Functions of the multi-interacting protein KIDINS220/ARMS in cancer and other pathologies.
Hydrolysis of nucleoside triphosphate in plasma membranes of the hepatocytes of normal, regenerating and foetal livers and in cancer cells of hepatomas.
Imatinib mesylate affects extracellular ATP catabolism and expression of NTPDases in a chronic myeloid leukemia cell line.
Increased expression of peripheral benzodiazepine receptor (PBR) in dimethylbenz[a]anthracene-induced mammary tumors in rats.
Kidins220 and tumour development: Insights into a complexity of cross-talk among signalling pathways (Review).
Kidins220/ARMS depletion is associated with the neural-to Schwann-like transition in a human neuroblastoma cell line model.
Localization of NTPDase1/CD39 in normal and transformed human pancreas.
NTPDase and 5' ecto-nucleotidase expression profiles and the pattern of extracellular ATP metabolism in the Walker 256 tumor.
Nucleocytoplasmic RNA transport.
Nucleoside triphosphatase activity in induced mammary tumours in rats.
Nucleotide degrading enzymes in platelets from uterine cervical neoplasia patients treated with conization or radiotherapy.
On the cytotoxicity of HCR-NTPase in the neuroblastoma cell line SH-SY5Y.
Overexpression of NTPDase2 in gliomas promotes systemic inflammation and pulmonary injury.
Purification and properties of a nucleoside triphosphatase from Sinclair swine.
Radiolabeled 6-(2, 3-Dichlorophenyl)-N4-methylpyrimidine-2, 4-diamine (TH287): A Potential Radiotracer for Measuring and Imaging MTH1.
Reduced kinase D?interacting substrate of 220 kDa (Kidins220) in pancreatic cancer promotes EGFR/ERK signalling and disease progression.
Selective NTPDase2 expression modulates in vivo rat glioma growth.
Selective nucleoside triphosphate diphosphohydrolase-2 (NTPDase2) inhibitors: nucleotide mimetics derived from uridine-5'-carboxamide.
The Epstein-Barr virus nuclear antigen-1 upregulates the cellular antioxidant defense to enable B-cell growth transformation and immortalization.
The hepatitis C virus protein NS3 suppresses TNF-?-stimulated activation of NF-?B by targeting LUBAC.
The reovirus ?2 C-terminal loop inversely regulates NTPase and transcription functions versus binding to factory-forming ?NS and promotes replication in tumorigenic cells.
The role of NK cells and CD39 in the immunological control of tumor metastases.
Upregulated ankyrin repeat-rich membrane spanning protein contributes to tumour progression in cutaneous melanoma.
Vascular CD39/ENTPD1 Directly Promotes Tumor Cell Growth by Scavenging Extracellular Adenosine Triphosphate.
[Effect of antiestrogen and antiandrogen derivatives of acylhydrazines on properties of nucleoside triphosphatases and adenyl nucleotide content of nuclei of normal and tumor cells]
Neuroblastoma
Complex changes in ecto-nucleoside 5'-triphosphate diphosphohydrolase expression in hypoxanthine phosphoribosyl transferase deficiency.
Nucleoside triphosphatase activity at the external surface of neuroblastoma cells.
On the cytotoxicity of HCR-NTPase in the neuroblastoma cell line SH-SY5Y.
Neurodegenerative Diseases
Development of Anthraquinone Derivatives as Ectonucleoside Triphosphate Diphosphohydrolase (NTPDase) Inhibitors With Selectivity for NTPDase2 and NTPDase3.
Kidins220 accumulates with tau in human Alzheimer's disease and related models: modulation of its calpain-processing by GSK3?/PP1 imbalance.
Stepping Out of the Shade: Control of Neuronal Activity by the Scaffold Protein Kidins220/ARMS.
Neurofibroma
The neurofibromatosis 1 gene transcripts expressed in peripheral nerve and neurofibromas bear the additional exon located in the GAP domain.
Neuroinflammatory Diseases
Expression of Ecto-Nucleoside Triphosphate Diphosphohydrolase1-3 (NTPDase1-3) by Cortical Astrocytes After Exposure to Pro-inflammatory Factors In Vitro.
nucleoside-triphosphate phosphatase deficiency
Kidins220 deficiency causes ventriculomegaly via SNX27-retromer-dependent AQP4 degradation.
Obesity
Atypical, milder presentation in a child with CC2D2A and KIDINS220 variants.
Genetic and Clinical Profile of Chinese Patients with Autosomal Dominant Spastic Paraplegia.
Heterozygous KIDINS220 mutation leads to spastic paraplegia and obesity in an Asian girl.
Homozygous KIDINS220 loss-of-function variants in fetuses with cerebral ventriculomegaly and limb contractures.
Prenatal delineation of a distinct lethal fetal syndrome caused by a homozygous truncating KIDINS220 variant.
Oligospermia
Mutations in the testis-specific NALP14 gene in men suffering from spermatogenic failure.
Osteoarthritis
Synovial fluid pyrophosphate and nucleoside triphosphate pyrophosphatase: comparison between normal and diseased and between inflamed and non-inflamed joints.
Pancreatic Neoplasms
Reduced kinase D?interacting substrate of 220 kDa (Kidins220) in pancreatic cancer promotes EGFR/ERK signalling and disease progression.
Paraplegia
Atypical, milder presentation in a child with CC2D2A and KIDINS220 variants.
Genetic and Clinical Profile of Chinese Patients with Autosomal Dominant Spastic Paraplegia.
Heterozygous KIDINS220 mutation leads to spastic paraplegia and obesity in an Asian girl.
Homozygous KIDINS220 loss-of-function variants in fetuses with cerebral ventriculomegaly and limb contractures.
Prenatal delineation of a distinct lethal fetal syndrome caused by a homozygous truncating KIDINS220 variant.
Parasitemia
Trypanosoma evansi: Activities of adenine nucleotide degradation enzymes in cerebral cortex of infected rats.
Parkinson Disease
MTH1, an oxidized purine nucleoside triphosphatase, protects the dopamine neurons from oxidative damage in nucleic acids caused by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
Periodontal Diseases
Periodontal disease and high doses of inhaled corticosteroids alter NTPDase activity in the blood serum of rats.
Polycystic Kidney Diseases
STAND, a class of P-loop NTPases including animal and plant regulators of programmed cell death: multiple, complex domain architectures, unusual phyletic patterns, and evolution by horizontal gene transfer.
Prostatic Neoplasms
MiR-4638-5p inhibits castration resistance of prostate cancer through repressing Kidins220 expression and PI3K/AKT pathway activity.
Pythiosis
Immunotherapy for pythiosis: Effect on NTPDase activity in lymphocytes of an experimental model.
Reperfusion Injury
Liver damage and systemic inflammatory responses are exacerbated by the genetic deletion of CD39 in total hepatic ischemia.
Recombinant adenoviral mediated CD39 gene transfer prolongs cardiac xenograft survival.
Retinal Degeneration
Lysosomal alkalinization, lipid oxidation, and reduced phagosome clearance triggered by activation of the P2X7 receptor.
Rubella
Identification of an RNA-stimulated NTPase in the predicted helicase sequence of the Rubella virus nonstructural polyprotein.
Immunogenic compositions assembled from tobacco mosaic virus-generated spherical particle platforms and foreign antigens.
Salmonella Infections
Ectonucleotidases and adenosine deaminase activity in laying hens naturally infected by Salmonella Gallinarum and their effects on the pathogenesis of the disease.
Schistosomiasis
Anti-schistosome antibodies change NTPDase 1 activity from macrophages.
Seizures
A genetic context for the study of audiogenic seizures.
Biochemical brain markers and purinergic parameters in rat CSF after seizure induced by pentylenetetrazol.
Sepsis
Increased NTPDase activity in lymphocytes during experimental sepsis.
Targeting CD39 Toward Activated Platelets Reduces Systemic Inflammation and Improves Survival in Sepsis: A Preclinical Pilot Study.
Severe Acute Respiratory Syndrome
A high ATP concentration enhances the cooperative translocation of the SARS coronavirus helicase nsP13 in the unwinding of duplex RNA.
Biochemical Characterization of Middle East Respiratory Syndrome Coronavirus Helicase.
Chemical constituents from coconut waste and their in silico evaluation as potential antiviral agents against SARS-CoV-2.
Deducing the Crystal Structure of MERS-CoV Helicase.
Delicate structural coordination of the Severe Acute Respiratory Syndrome coronavirus Nsp13 upon ATP hydrolysis.
Differential inhibitory activities and stabilisation of DNA aptamers against the SARS coronavirus helicase.
Investigation of the pharmacophore space of Severe Acute Respiratory Syndrome coronavirus (SARS-CoV) NTPase/helicase by dihydroxychromone derivatives.
Isolation of inhibitory RNA aptamers against severe acute respiratory syndrome (SARS) coronavirus NTPase/Helicase.
Plant-derived exosomal microRNAs inhibit lung inflammation induced by exosomes SARS-CoV-2 Nsp12.
The severe acute respiratory syndrome (SARS) coronavirus NTPase/helicase belongs to a distinct class of 5' to 3' viral helicases.
Spasm
Heterozygous KIDINS220/ARMS nonsense variants cause spastic paraplegia, intellectual disability, nystagmus, and obesity.
Starvation
Crystal structure of Escherichia coli MazG, the regulator of nutritional stress response.
Stroke
Selective nucleoside triphosphate diphosphohydrolase-2 (NTPDase2) inhibitors: nucleotide mimetics derived from uridine-5'-carboxamide.
Subacute Sclerosing Panencephalitis
SspABCD-SspE is a phosphorothioation-sensing bacterial defence system with broad anti-phage activities.
SspABCD-SspFGH Constitutes a New Type of DNA Phosphorothioate-Based Bacterial Defense System.
Thrombocytopenia
Activities of adenine nucleotide and nucleoside degradation enzymes in platelets of rats infected by Trypanosoma evansi.
Thrombosis
2-hexylthio-?,?-CH2-ATP is an effective and selective NTPDase2 inhibitor.
8-BuS-ATP derivatives as specific NTPDase1 inhibitors.
Ectonucleotidases as regulators of purinergic signaling in thrombosis, inflammation, and immunity.
NTPDase and 5'-nucleotidase activities in platelets of human pregnants with a normal or high risk for thrombosis.
Toxoplasmosis
Evaluation of serodiagnosis of toxoplasmosis by using the recombinant nucleoside triphosphate hydrolase isoforms expressed in Escherichia coli.
Kinetics of the nucleoside triphosphate hydrolase of Toxoplasma gondii in mice with acute and chronic toxoplasmosis.
The relationship between nucleoside triphosphate hydrolase (NTPase) isoform and Toxoplasma strain virulence in rat and human toxoplasmosis.
Trichomonas Infections
Iron from haemoglobin and haemin modulates nucleotide hydrolysis in Trichomonas vaginalis.
Tuberculosis
Mycobacterium tuberculosis Rho is an NTPase with distinct kinetic properties and a novel RNA-binding subdomain.
Vaccinia
A carboxy terminal domain of the L protein of rinderpest virus possesses RNA triphosphatase activity - The first enzyme in the viral mRNA capping pathway.
A mutation of the nucleoside triphosphate phosphohydrolase I (NPH-I) gene confers sensitivity of vaccinia virus to interferon.
Determinants of vaccinia virus early gene transcription termination.
DNA sequence of the nucleoside triphosphate phosphohydrolase I (NPH I) of the Choristoneura biennis entomopoxvirus.
Domain structure of the vaccinia virus mRNA capping enzyme. Expression in Escherichia coli of a subdomain possessing the RNA 5'-triphosphatase and guanylyltransferase activities and a kinetic comparison to the full-size enzyme.
Effect of selected mutations in the C-terminal region of the vaccinia virus nucleoside triphosphate phosphohydrolase I on binding to the H4L subunit of the viral RNA polymerase and early gene transcription termination in vitro.
Histidine codons appended to the gene encoding the RPO22 subunit of vaccinia virus RNA polymerase facilitate the isolation and purification of functional enzyme and associated proteins from virus-infected cells.
Identification of the point mutations in two vaccinia virus nucleoside triphosphate phosphohydrolase I temperature-sensitive mutants and role of this DNA-dependent ATPase enzyme in virus gene expression.
Identification of the vaccinia virus gene encoding nucleoside triphosphate phosphohydrolase I, a DNA-dependent ATPase.
Interaction between nucleoside triphosphate phosphohydrolase I and the H4L subunit of the viral RNA polymerase is required for vaccinia virus early gene transcript release.
Interaction of the vaccinia virus nucleoside triphosphate phosphohydrolase I with linear oligonucleotides.
Molecular cloning, encoding sequence, and expression of vaccinia virus nucleic acid-dependent nucleoside triphosphatase gene.
Mutational analysis of vaccinia virus nucleoside triphosphate phosphohydrolase I, a DNA-dependent ATPase of the DExH box family.
Mutational analysis of vaccinia virus nucleoside triphosphate phosphohydrolase II, a DExH box RNA helicase.
Nucleoside Triphosphate Phosphohydrolase I (NPH I) Functions as a 5' to 3' Translocase in Transcription Termination of Vaccinia Early Genes.
Nucleotide sequence of a nucleoside triphosphate phosphohydrolase gene from African swine fever virus.
Products and substrate/template usage of vaccinia virus DNA primase.
Protection of mice against yellow fever virus encephalitis by immunization with a vaccinia virus recombinant encoding the yellow fever virus non-structural proteins, NS1, NS2a and NS2b.
RNA 5'-triphosphatase, nucleoside triphosphatase, and guanylyltransferase activities of baculovirus LEF-4 protein.
Role of forward translocation in nucleoside triphosphate phosphohydrolase I (NPH I)-mediated transcription termination of vaccinia virus early genes.
Sedimentation of an RNA polymerase complex from vaccinia virus that specifically initiates and terminates transcription.
The nucleoside triphosphatase and helicase activities of vaccinia virus NPH-II are essential for virus replication.
The role of vaccinia termination factor and cis-acting elements in vaccinia virus early gene transcription termination.
The vaccinia virus D5 protein, which is required for DNA replication, is a nucleic acid-independent nucleoside triphosphatase.
The viral RNA polymerase H4L subunit is required for Vaccinia virus early gene transcription termination.
UUUUUNU oligonucleotide stimulation of vaccinia virus early gene transcription termination, in trans.
Vaccinia virions lacking the RNA helicase nucleoside triphosphate phosphohydrolase II are defective in early transcription.
Vaccinia virus early gene transcription termination factors VTF and Rap94 interact with the U9 termination motif in the nascent RNA in a transcription ternary complex.
Vaccinia virus encodes four putative DNA and/or RNA helicases distantly related to each other.
Vaccinia virus nucleoside triphosphate phosphohydrolase I controls early and late gene expression by regulating the rate of transcription.
Vaccinia virus nucleoside triphosphate phosphohydrolase I is an essential viral early gene transcription termination factor.
Yeast and viral RNA 5' triphosphatases comprise a new nucleoside triphosphatase family.
Virus Diseases
Development of an infectious clone and replicon system of norovirus GII.4.
Emetine, a potent alkaloid for the treatment of SARS-CoV-2 targeting papain-like protease and non-structural proteins: pharmacokinetics, molecular docking and dynamic studies.
Heterogeneity in extracellular nucleotide hydrolysis among clinical isolates of Trichomonas vaginalis.
Inhibition of RNA Helicases of ssRNA(+) Virus Belonging to Flaviviridae, Coronaviridae and Picornaviridae Families.
Koala and wombat gammaherpesviruses encode the first known viral nucleoside triphosphate diphosphohydrolase (NTPDase) homologs and are phylogenetically divergent from all known gammaherpesviruses.
Phosphorylation of the potyvirus capsid protein by protein kinase CK2 and its relevance for virus infection.
Yellow Fever
Protection of mice against yellow fever virus encephalitis by immunization with a vaccinia virus recombinant encoding the yellow fever virus non-structural proteins, NS1, NS2a and NS2b.
RNA-stimulated NTPase activity associated with yellow fever virus NS3 protein expressed in bacteria.
The two-component NS2B-NS3 proteinase represses DNA unwinding activity of the West Nile virus NS3 helicase.