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1,Nepsilon-etheno-ADP-ribose + H2O
1,Nepsilon-etheno-AMP-ribose + phosphate
-
fluorogenic substrate
the product is converted to fluorescent 1,Nepsilon-etheno-adenosine by alkaline phosphatase for detection
-
?
2''-O-acetyl-ADP-ribose + H2O
AMP + 2-O-acetyl-D-ribose 5-phosphate
-
-
-
-
?
8-oxo-dADP + H2O
?
-
-
-
?
8-oxo-dGDP + H2O
8-oxo-dGMP + phosphate
-
-
-
?
8-oxo-dGDP + H2O
?
-
-
-
?
8-oxo-dGTP + H2O
?
the enzyme hardly acts on 8-oxo-dGTP
-
-
?
ADP + H2O
AMP + phosphate
-
-
-
?
ADP-alpha-D-ribose + H2O
AMP + D-ribose 5-phosphate
ADP-D-ribose + H2O
AMP + D-ribose 5-phosphate
ADP-glucose + H2O
AMP + alpha-D-glucose 1-phosphate
ADP-mannose + H2O
AMP + D-mannose 1-phosphate
ADP-ribose + H2O
AMP + D-ribose 5-phosphate
ADP-ribose + H2O
AMP + ribose 5-phosphate
ADPribose + H2O
AMP + D-ribose 5-phosphate
ADPribose 2'-phosphate + H2O
adenosine 2',5'-diphosphate + D-ribose 5-phosphate
-
-
-
-
?
cADP-ribose + H2O
N1-(5-phosphoribosyl)-AMP + phosphate
CDP-choline + H2O
CMP + choline phosphate
CDP-choline + H2O
CMP + phosphocholine
reaction of EC 3.6.1.53
-
-
?
CDP-ethanolamine + H2O
CMP + ethanolamine phosphate
-
-
-
?
CDP-glucose + H2O
CMP + glucose 5-phosphate
-
at 5% of the activity with ADPribose
-
-
?
CDP-glycerol + H2O
CMP + glycerol phosphate
-
-
-
?
CDP-ribose + H2O
CMP + D-ribose 5-phosphate
-
kcat/Km is 2.5% of the kcat/Km for ADP-ribose
-
-
?
cyclic ADP-ribose + H2O
N1-(5-phosphoribosyl)-AMP
-
-
-
?
diadenosine 5',5''-diphosphate + H2O
?
20% the activity with ADP-ribose
-
-
?
GDP-glucose + H2O
GMP + glucose 5-phosphate
GDP-mannose + H2O
GMP + D-mannose 1-phosphate
GDP-ribose + H2O
GMP + D-ribose 5-phosphate
-
kcat/Km is 3% of the kcat/Km for ADP-ribose
-
-
?
IDP-ribose + H2O
IMP + D-ribose 5-phosphate
-
138% of the activity with ADPribose
-
-
?
IDP-ribose + H2O
IMP + ribose 5-phosphate
IDPribose + H2O
IMP + D-ribose 5-phosphate
77% of the activity with ADPribose
-
-
?
NAD+ + H2O
?
-
ADPRibase-Mn in presence of Mn2+, no activity with ADPRibase I and ADPRibase II
-
-
?
NAD+ + H2O
AMP + NMN
7% of the activity with ADP-ribose
-
-
?
NADP+ + H2O
nicotinic acid mononucleotide + phosphate
-
-
-
?
NADPH + H2O
AMP + ?
12% of the activity with ADP-ribose
-
-
?
UDP-galactose + H2O
UDP + galactose
7% of the activity with ADP-ribose
-
-
?
UDP-glucose + H2O
UMP + glucose 5-phosphate
UDP-mannose + H2O
UMP + D-mannose 1-phosphate
additional information
?
-
2',3'-cAMP + H2O

3'AMP
-
95% of products
-
?
2',3'-cAMP + H2O
3'AMP
-
-
-
?
ADP-alpha-D-ribose + H2O

AMP + D-ribose 5-phosphate
-
-
-
?
ADP-alpha-D-ribose + H2O
AMP + D-ribose 5-phosphate
-
-
-
?
ADP-D-ribose + H2O

AMP + D-ribose 5-phosphate
-
-
-
?
ADP-D-ribose + H2O
AMP + D-ribose 5-phosphate
-
-
-
-
?
ADP-D-ribose + H2O
AMP + D-ribose 5-phosphate
-
-
-
?
ADP-D-ribose + H2O
AMP + D-ribose 5-phosphate
-
-
-
?
ADP-D-ribose + H2O
AMP + D-ribose 5-phosphate
-
-
-
-
?
ADP-glucose + H2O

?
low activity
-
-
?
ADP-glucose + H2O
?
low activity
-
-
?
ADP-glucose + H2O

AMP + alpha-D-glucose 1-phosphate
-
at 21% of the activity with ADPribose
-
-
?
ADP-glucose + H2O
AMP + alpha-D-glucose 1-phosphate
56% of the activity with ADP-ribose
-
-
?
ADP-glucose + H2O
AMP + alpha-D-glucose 1-phosphate
about 70% of the activity with ADP-mannose
-
-
?
ADP-glucose + H2O
AMP + alpha-D-glucose 1-phosphate
-
about 70% of the activity with ADP-ribose
-
-
?
ADP-glucose + H2O
AMP + alpha-D-glucose 1-phosphate
-
ADPRibase II, very low activity with ADPRibase I
-
-
?
ADP-glucose + H2O
AMP + alpha-D-glucose 1-phosphate
9% of the activity with ADPribose
-
-
?
ADP-glucose + H2O
AMP + alpha-D-glucose 1-phosphate
-
kcat/Km is 3% of the kcat/Km for ADP-ribose
-
-
?
ADP-mannose + H2O

AMP + D-mannose 1-phosphate
-
-
-
?
ADP-mannose + H2O
AMP + D-mannose 1-phosphate
-
at 70% of the activity with ADPribose
-
-
?
ADP-mannose + H2O
AMP + D-mannose 1-phosphate
103% of the activity with ADP-ribose
-
-
?
ADP-mannose + H2O
AMP + D-mannose 1-phosphate
-
about 80% of the activity with ADP-ribose
-
-
?
ADP-mannose + H2O
AMP + D-mannose 1-phosphate
-
ADPRibase II, low activity with ADPRibase I
-
-
?
ADP-ribose + H2O

AMP + D-ribose 5-phosphate
-
Growth Factor Gene 1 (GFG1, At4g12720) encodes a nudix hydrolase, that is an NADH pyrophosphatase and ADP-ribose pyrophosphatase
-
-
?
ADP-ribose + H2O
AMP + D-ribose 5-phosphate
-
-
-
?
ADP-ribose + H2O
AMP + D-ribose 5-phosphate
-
-
-
?
ADP-ribose + H2O
AMP + D-ribose 5-phosphate
-
AtNUDT10 shows both ADP-ribose and NADH pyrophosphatase activity
-
-
?
ADP-ribose + H2O
AMP + D-ribose 5-phosphate
-
AtNUDT2 shows both ADP-ribose and NADH pyrophosphatase activity
-
-
?
ADP-ribose + H2O
AMP + D-ribose 5-phosphate
-
AtNUDT6 shows both ADP-ribose and NADH pyrophosphatase activity
-
-
?
ADP-ribose + H2O
AMP + D-ribose 5-phosphate
-
AtNUDT7 shows both ADP-ribose and NADH pyrophosphatase activity
-
-
?
ADP-ribose + H2O
AMP + D-ribose 5-phosphate
-
-
-
-
?
ADP-ribose + H2O
AMP + D-ribose 5-phosphate
-
-
-
?
ADP-ribose + H2O
AMP + D-ribose 5-phosphate
-
-
-
?
ADP-ribose + H2O
AMP + D-ribose 5-phosphate
substrate binding structure, overview
-
-
?
ADP-ribose + H2O
AMP + D-ribose 5-phosphate
-
-
-
-
?
ADP-ribose + H2O
AMP + D-ribose 5-phosphate
-
-
-
?
ADP-ribose + H2O
AMP + D-ribose 5-phosphate
preferred substrate
-
-
?
ADP-ribose + H2O
AMP + D-ribose 5-phosphate
-
the enzyme may have a predominant role in free ADP-ribose turnover and as a protective agent preventing the accumulation of this potential dangerous metabolite
-
-
?
ADP-ribose + H2O
AMP + D-ribose 5-phosphate
-
protective enzyme whose function is to limit the intracellular accumulation of ADP-ribose
-
-
?
ADP-ribose + H2O
AMP + D-ribose 5-phosphate
the enzyme plays important roles in controlling the intracellular levels of ADPR and preventing non-enzymatic ADP-ribosylation of proteins by hydrolyzing ADPR to AMP and ribose 5?-phosphate
-
-
?
ADP-ribose + H2O
AMP + D-ribose 5-phosphate
-
-
-
-
?
ADP-ribose + H2O
AMP + D-ribose 5-phosphate
-
-
-
?
ADP-ribose + H2O
AMP + D-ribose 5-phosphate
-
ADP-ribose pyrophosphatase Sll1054 hydrolyzes ADP-ribose specifically
-
-
?
ADP-ribose + H2O
AMP + D-ribose 5-phosphate
-
ADP-ribose pyrophosphatase Slr0920 hydrolyzes ADP-ribose specifically
-
-
?
ADP-ribose + H2O
AMP + D-ribose 5-phosphate
-
ADP-ribose pyrophosphatase Slr1134 hydrolyzes ADP-ribose, NADH and flavin adenine dinucleotide
-
-
?
ADP-ribose + H2O
AMP + D-ribose 5-phosphate
substrate binding structure, overview
-
-
?
ADP-ribose + H2O
AMP + D-ribose 5-phosphate
-
-
-
-
?
ADP-ribose + H2O
AMP + D-ribose 5-phosphate
-
-
-
?
ADP-ribose + H2O
AMP + D-ribose 5-phosphate
-
the enzyme plays a key role in regulating the intracellular ADPribose levels, and prevents nonenzymatic ADP-ribosylation
-
-
?
ADP-ribose + H2O
AMP + D-ribose 5-phosphate
highly specific substrate
-
-
?
ADP-ribose + H2O
AMP + D-ribose 5-phosphate
-
interactions responsible for the substrate recognition are located at the terminal moieties of the substrate. The adenine moiety is recognized by Ile-19 and the main chain carbonyl group of Glu-29 and/or Gly-104. The terminal ribose moiety is recognized by the sum of some weak interactions with multiple residues that are close in space. Glu-82 and Glu-86 are essential for catalysis but unlikely to act as a catalytic base. Two-metal ion mechanism for the catalysis of ADPRase in which a water molecule is activated to act as a nucleophile by the cations coordinated by Glu-82 and Glu-86. Arg-54, Glu-70, Arg-81, and Glu-85 are predicted to support this nucleophilic attack on the R-phosphate of the substrate
-
-
?
ADP-ribose + H2O
AMP + D-ribose 5-phosphate
preferred substrate, substrate recognition and binding structure, overview
-
-
?
ADP-ribose + H2O
AMP + D-ribose 5-phosphate
-
-
-
-
?
ADP-ribose + H2O
AMP + D-ribose 5-phosphate
-
the enzyme plays a key role in regulating the intracellular ADPribose levels, and prevents nonenzymatic ADP-ribosylation
-
-
?
ADP-ribose + H2O
AMP + D-ribose 5-phosphate
highly specific substrate
-
-
?
ADP-ribose + H2O
AMP + D-ribose 5-phosphate
-
-
-
?
ADP-ribose + H2O
AMP + D-ribose 5-phosphate
preferred substrate, substrate recognition and binding structure, overview
-
-
?
ADP-ribose + H2O

AMP + ribose 5-phosphate
-
-
-
?
ADP-ribose + H2O
AMP + ribose 5-phosphate
the function of the enzyme might be to remove free ADP-ribose arising from NAD+ and protein-bound poly- and non-enzymic protein glycation
-
-
?
ADP-ribose + H2O
AMP + ribose 5-phosphate
about 65% of the activity with ADP-mannose
-
-
?
ADP-ribose + H2O
AMP + ribose 5-phosphate
ADP-ribose is a better substrate compared with 8-oxo-dGDP
-
-
?
ADP-ribose + H2O
AMP + ribose 5-phosphate
-
-
-
-
?
ADPribose + H2O

AMP + D-ribose 5-phosphate
-
-
-
-
?
ADPribose + H2O
AMP + D-ribose 5-phosphate
-
-
-
?
ADPribose + H2O
AMP + D-ribose 5-phosphate
the enzyme may play a role in tellurite resistance
-
-
?
ADPribose + H2O
AMP + D-ribose 5-phosphate
-
-
-
-
?
ADPribose + H2O
AMP + D-ribose 5-phosphate
-
the enzyme may play a role in tellurite resistance
-
-
?
ADPribose + H2O
AMP + D-ribose 5-phosphate
-
-
-
-
?
ADPribose + H2O
AMP + D-ribose 5-phosphate
-
-
-
?
ADPribose + H2O
AMP + D-ribose 5-phosphate
-
the enzyme may play a role in tellurite resistance
-
-
?
ADPribose + H2O
AMP + D-ribose 5-phosphate
nucleophilic attack at the adenosyl phosphate. The enzyme cycles between an open free enzyme and a closed substrate-metal complex conformation. This cycling may be important in preventing nonspecific hydrolysis of other nucleotides
-
-
?
ADPribose + H2O
AMP + D-ribose 5-phosphate
-
-
-
?
ADPribose + H2O
AMP + D-ribose 5-phosphate
the enzyme may play a role in tellurite resistance
-
-
?
ADPribose + H2O
AMP + D-ribose 5-phosphate
-
-
-
?
ADPribose + H2O
AMP + D-ribose 5-phosphate
-
-
-
-
?
ADPribose + H2O
AMP + D-ribose 5-phosphate
-
-
-
?
ADPribose + H2O
AMP + D-ribose 5-phosphate
-
the enzyme may play an important role in the regulation of intracellular steady-state of free ADPribose
-
-
?
ADPribose + H2O
AMP + D-ribose 5-phosphate
-
-
-
?
ADPribose + H2O
AMP + D-ribose 5-phosphate
-
-
-
-
?
ADPribose + H2O
AMP + D-ribose 5-phosphate
-
the enzyme may play a role in tellurite resistance
-
-
?
ADPribose + H2O
AMP + D-ribose 5-phosphate
-
-
-
?
ADPribose + H2O
AMP + D-ribose 5-phosphate
-
-
-
?
ADPribose + H2O
AMP + D-ribose 5-phosphate
-
-
-
?
ADPribose + H2O
AMP + D-ribose 5-phosphate
-
-
-
-
?
ADPribose + H2O
AMP + D-ribose 5-phosphate
-
-
-
-
?
ADPribose + H2O
AMP + D-ribose 5-phosphate
-
the enzyme may play a role in tellurite resistance
-
-
?
ADPribose + H2O
AMP + D-ribose 5-phosphate
-
-
-
?
cADP-ribose + H2O

N1-(5-phosphoribosyl)-AMP + phosphate
-
-
-
?
cADP-ribose + H2O
N1-(5-phosphoribosyl)-AMP + phosphate
-
-
-
?
CDP-choline + H2O

CMP + choline phosphate
-
-
-
?
CDP-choline + H2O
CMP + choline phosphate
-
-
-
?
FAD + H2O

?
-
ADPRibase-Mn and ADPRibase II, very low activity with ADPRibase I in presence of Mn2+
-
-
?
FAD + H2O
?
preferred substrate
-
-
?
FAD + H2O
?
preferred substrate
-
-
?
GDP-glucose + H2O

GMP + glucose 5-phosphate
7% of the activity with ADP-ribose
-
-
?
GDP-glucose + H2O
GMP + glucose 5-phosphate
about 15% of the activity with ADP-mannose
-
-
?
GDP-glucose + H2O
GMP + glucose 5-phosphate
-
about 15% of the activity with ADP-ribose
-
-
?
GDP-mannose + H2O

GMP + D-mannose 1-phosphate
-
-
-
-
?
GDP-mannose + H2O
GMP + D-mannose 1-phosphate
at 59% of the activity with ADPribose
-
-
?
GDP-mannose + H2O
GMP + D-mannose 1-phosphate
-
at 40% of the activity with ADPribose
-
-
?
GDP-mannose + H2O
GMP + D-mannose 1-phosphate
about 15% of the activity with ADP-mannose
-
-
?
GDP-mannose + H2O
GMP + D-mannose 1-phosphate
-
about 20% of the activity with ADP-ribose
-
-
?
GDP-mannose + H2O
GMP + D-mannose 1-phosphate
-
at 9% of the activity with ADPribose
-
-
?
GDP-mannose + H2O
GMP + D-mannose 1-phosphate
-
at 1% of the activity with ADPribose
-
-
?
IDP-ribose + H2O

IMP + ribose 5-phosphate
-
77% of the activity with ADPribose
-
-
?
IDP-ribose + H2O
IMP + ribose 5-phosphate
-
at 59% of the activity with ADPribose
-
-
?
IDP-ribose + H2O
IMP + ribose 5-phosphate
9% of the activity with ADP-ribose
-
-
?
IDP-ribose + H2O
IMP + ribose 5-phosphate
-
-
-
-
?
NADH + H2O

?
-
-
-
?
NADH + H2O
?
at 2% of the activity with ADPribose
-
-
?
NADH + H2O
?
-
at 9% of the activity with ADPribose
-
-
?
NADH + H2O
?
at 15% of the activity with ADPribose
-
-
?
NADH + H2O
?
-
ADPRibase I, ADPribase II and ADPRibase-Mn in presence of Mn2+
-
-
?
NADH + H2O
?
-
at 12% of the activity with ADPribose
-
-
?
NADH + H2O

AMP + NMNH
-
-
-
?
NADH + H2O
AMP + NMNH
-
-
-
?
NADH + H2O
AMP + NMNH
7% of the activity with ADP-ribose
-
-
?
NADH + H2O
AMP + NMNH
about 12% of the activity with ADP-mannose
-
-
?
NADH + H2O
AMP + NMNH
-
about 15% of the activity with ADP-ribose
-
-
?
UDP-glucose + H2O

UMP + glucose 5-phosphate
-
at 5% of the activity with ADPribose
-
-
?
UDP-glucose + H2O
UMP + glucose 5-phosphate
about 12% of the activity with ADP-mannose
-
-
?
UDP-glucose + H2O
UMP + glucose 5-phosphate
-
about 5% of the activity with ADP-ribose
-
-
?
UDP-mannose + H2O

UMP + D-mannose 1-phosphate
-
at 20% of the activity with ADPribose
-
-
?
UDP-mannose + H2O
UMP + D-mannose 1-phosphate
about 15% of the activity with ADP-mannose