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Adenocarcinoma of Lung
Proteomic analysis of lung adenocarcinoma: identification of a highly expressed set of proteins in tumors.
Adenoma, Pleomorphic
Ultrastructural cytochemistry of phosphatases in the ductal component of pleomorphic adenoma of human parotid and submandibular salivary glands.
Amyotrophic Lateral Sclerosis
Thiamin mono- and pyrophosphatase activities from brain homogenate of Guamanian amyotrophic lateral sclerosis and parkinsonism-dementia patients.
Anemia
[Biological dynamics of inorganic pyrophosphatase (PP-ase) hemorrhagic anemia.]
Anemia, Hemolytic
Behavior of the erythrocyte pyrophosphatase activity in the enzyme-deficiency haemolytic anaemias. II. A new test for the detection of the enzyme defect.
Anemia, Hemolytic
Behaviour of the erythrocyte pyrophosphatase activity in the enzyme-deficiency haemolytic anaemias. I. Quantitative modifications of the enzyme.
Ankylosis
Central role of pyrophosphate in acellular cementum formation.
Arthritis
In situ formation of fluorescent polydopamine catalyzed by peroxidase-mimicking FeCo-LDH for pyrophosphate ion and pyrophosphatase activity detection.
Avitaminosis
[Enzyme activity of thiamine diphosphate biosynthesis and degradation in the mouse liver in the dynamics of B1 avitaminosis development]
Bartter Syndrome
[A fortultousness association: Bartter's syndrome and chondrocalcinosis (author's transl)]
Bone Diseases
[Bone diseases and serum enzymes, with special reference to pyrophosphatase]
Bone Resorption
Influence of dichloromethylene diphosphonate (Cl2MDP) and calcitonin on bone resorption, lactate production and phosphatase and pyrophosphatase content of mouse calvaria treated with parathyroid hormone in vitro.
Breast Neoplasms
Identification of Critical Elements for Regulation of Inorganic Pyrophosphatase (PPA1) in MCF7 Breast Cancer Cells.
Carcinogenesis
Clinical significance and functional validation of inorganic pyrophosphatase in diffuse large B cell lymphoma in humans.
Carcinogenesis
Human dCTP pyrophosphatase 1 promotes breast cancer cell growth and stemness through the modulation on 5-methyl-dCTP metabolism and global hypomethylation.
Carcinogenesis
Vinyl sulfone analogs of lysophosphatidylcholine irreversibly inhibit autotaxin and prevent angiogenesis in melanoma.
Carcinoma
Discovery of the First Potent and Selective Inhibitors of Human dCTP Pyrophosphatase 1.
Carcinoma
Proteomic profiling identifies the inorganic pyrophosphatase (PPA1) protein as a potential biomarker of metastasis in laryngeal squamous cell carcinoma.
Carcinoma
Thiamine metabolism in the liver of mice with Ehrlich ascites carcinoma.
Carcinoma, Hepatocellular
A cytochemical study of acid phosphatase, thiamine pyrophosphatase and horseradish peroxidase in the Golgi-GERL complex of hepatoma ascites cells.
Carcinoma, Hepatocellular
Downregulation of LHPP Expression Associated with AFP Acts as a Good Prognostic Factor in Human Hepatocellular Carcinoma.
Carcinoma, Hepatocellular
Dynamic distribution of the Golgi marker thiamine pyrophosphatase is modulated by brefeldin A in rat hepatoma cells.
Carcinoma, Hepatocellular
LHPP suppresses bladder cancer cell proliferation and growth via inactivating AKT/p65 signaling pathway.
Carcinoma, Hepatocellular
Purification and properties of inorganic pyrophosphatase of rat liver and hepatoma 3924A.
Carcinoma, Hepatocellular
Subcellular distribution of inorganic pyrophosphatase activity in various normal and neoplastic cell types.
Carcinoma, Hepatocellular
Tumor suppressor LHPP regulates the proliferation of colorectal cancer cells via the PI3K/AKT pathway.
Carcinoma, Hepatocellular
[Investigation of the lipid dependence of pyrophosphatase activity from rat liver microsomes and hepatoma by phospholipase C]
Carcinoma, Hepatocellular
[Lipid dependence of the pyrophosphatase activity of microsomes from rat liver and hepatoma]
Carcinoma, Ovarian Epithelial
Expression of Inorganic Pyrophosphatase (PPA1) Correlates with Poor Prognosis of Epithelial Ovarian Cancer.
Cardiomyopathies
Sudden unexpected death in asymptomatic infants due to PPA2 variants.
Cholangiocarcinoma
Pyrophosphatase 1 expression is associated with future recurrence and overall survival in Chinese patients with intrahepatic cholangiocarcinoma.
Cholera
Structural and kinetic features of family I inorganic pyrophosphatase from Vibrio cholerae.
Chondrocalcinosis
Erythrocyte neutral inorganic pyrophosphatase in pseudogout.
Chondrocalcinosis
Inorganic pyrophosphatase activity of the synovial fluid. Kinetic and clinical study.
Chondrocalcinosis
[A fortultousness association: Bartter's syndrome and chondrocalcinosis (author's transl)]
Chondrocalcinosis
[Plasmatic neutral inorganic pyrophosphatase and alkaline phosphatase activities in patients with chondrocalcinosis and controls (author's transl)]
Colitis
RNF186 regulates EFNB1 (ephrin B1)-EPHB2-induced autophagy in the colonic epithelial cells for the maintenance of intestinal homeostasis.
Colitis, Ulcerative
RNF186 regulates EFNB1 (ephrin B1)-EPHB2-induced autophagy in the colonic epithelial cells for the maintenance of intestinal homeostasis.
Colorectal Neoplasms
The 1,2-Diaminocyclohexane Carrier Ligand in Oxaliplatin Induces p53-Dependent Transcriptional Repression of Factors Involved in Thymidylate Biosynthesis.
Crohn Disease
RNF186 regulates EFNB1 (ephrin B1)-EPHB2-induced autophagy in the colonic epithelial cells for the maintenance of intestinal homeostasis.
Death, Sudden, Cardiac
PPA2-associated sudden cardiac death: extending the clinical and allelic spectrum in 20 new families.
Death, Sudden, Cardiac
Sudden Cardiac Death Due to Deficiency of the Mitochondrial Inorganic Pyrophosphatase PPA2.
Dehydration
Expression and responses to dehydration and salinity stresses of V-PPase gene members in wheat.
Dental Calculus
Inorganic pyrophosphatase activity in a plaque calcifying microorganism: Bacterionema matruchotii.
Dental Plaque
[Ultrastructural cytochemistry of acid phosphatase and pyrophosphatase in human dental plaque]
Diabetes Mellitus
Osteoblast-specific deficiency of ectonucleotide pyrophosphatase or phosphodiesterase-1 engenders insulin resistance in high-fat diet fed mice.
Diabetes Mellitus, Type 2
Osteoblast-specific deficiency of ectonucleotide pyrophosphatase or phosphodiesterase-1 engenders insulin resistance in high-fat diet fed mice.
Diphtheria
[Thiamine pyrophosphatase in experimental diphtheria intoxication]
Dwarfism
Vacuolar H+-Pyrophosphatase and Cytosolic Soluble Pyrophosphatases Cooperatively Regulate Pyrophosphate Levels in Arabidopsis thaliana.
Encephalitis, Tick-Borne
[A comparison of pyrophosphatase and peroxidase as markers in the immunoenzyme analysis of the tick-borne encephalitis virus and antibodies to it]
Fibromyalgia
CSF levels of apolipoprotein C1 and autotaxin found to associate with neuropathic pain and fibromyalgia.
Gastrointestinal Neoplasms
Inorganic pyrophosphatase (PPA1) is a negative prognostic marker for human gastric cancer.
Glioblastoma
LHPP exerts a tumor-inhibiting role in glioblastoma via the downregulation of Akt and Wnt/?-catenin signaling.
Glycogen Storage Disease
Genetic evidence for the common identity of glucose-6-phosphatase, pyrophosphate-glucose phosphotransferase, carbamyl phosphate-glucose phosphotransferase and inorganic pyrophosphatase.
Graves Disease
Expression of new human inorganic pyrophosphatase in thyroid diseases: Its intimate association with hyperthyroidism.
h+-transporting two-sector atpase deficiency
A plant proton-pumping inorganic pyrophosphatase functionally complements the vacuolar ATPase transport activity and confers bafilomycin resistance in yeast.
Heart Arrest
Ultrastructural localization of thiamine pyrophosphatase in plasma membranes of brain phagocytes long time after cardiac arrest.
Heart Failure
Postmortem diagnosis of PPA2-associated sudden cardiac death from dried blood spot in a neonate presenting with vocal cord paralysis.
Hyperthyroidism
Expression of new human inorganic pyrophosphatase in thyroid diseases: Its intimate association with hyperthyroidism.
Hyperthyroidism
[Action of detergents on G-6-P phosphohydrolase, pyrophosphatase and PPi-glucose phosphotransferase in the liver of hyperthyroid rats]
Hypophosphatasia
Normal activity of nucleoside triphosphate pyrophosphatase in alkaline phosphatase-deficient fibroblasts from patients with infantile hypophosphatasia.
Hypophosphatasia
Serum alkaline phosphatase, serum pyrophosphatase, phosphorylethanolamine and inorganic pyrophosphate in plasma and urine. A genetic and clinical study of hypophosphatasia.
Infections
Analysis of stress- and host cell-induced expression of the Mycobacterium tuberculosis inorganic pyrophosphatase.
Infections
Flavin metabolism during respiratory infection in mice.
Infections
Induced expression of the Legionella pneumophila gene encoding a 20-kilodalton protein during intracellular infection.
Infections
Molecular characterization and transcriptional regulation of two types of H+-pyrophosphatases in the scuticociliate parasite Philasterides dicentrarchi.
Infections
Mycobacterium tuberculosis Rv3628 drives Th1-type T cell immunity via TLR2-mediated activation of dendritic cells and displays vaccine potential against the hyper-virulent Beijing K strain.
Infections
Subcellular localization of rickettsial invasion protein, InvA.
Inflammatory Bowel Diseases
RNF186 regulates EFNB1 (ephrin B1)-EPHB2-induced autophagy in the colonic epithelial cells for the maintenance of intestinal homeostasis.
Influenza, Human
[Studies on pyrophosphatase activity in the blood in influenza patients.]
inorganic diphosphatase deficiency
Inorganic pyrophosphatase defects lead to cell cycle arrest and autophagic cell death through NAD+-depletion in fermenting yeast.
Insulin Resistance
Osteoblast-specific deficiency of ectonucleotide pyrophosphatase or phosphodiesterase-1 engenders insulin resistance in high-fat diet fed mice.
Insulin Resistance
The role of membrane glycoprotein plasma cell antigen 1/ectonucleotide pyrophosphatase phosphodiesterase 1 in the pathogenesis of insulin resistance and related abnormalities.
Iron Deficiencies
The H+-pyrophosphatase IbVP1 regulates carbon flux to influence the starch metabolism and yield of sweet potato.
Joint Diseases
Adenosine triphosphate pyrophosphohydrolase and neutral inorganic pyrophosphatase in pathologic joint fluids. Elevated pyrophosphohydrolase in calcium pyrophosphate dihydrate crystal deposition disease.
Leukemia
[Activity of inorganic pyrophosphatase of erythrocytes in children with acute leukemia]
Leukemia, Hairy Cell
Biochemical characterization of the tartrate-resistant acid phosphatase of human spleen with leukemic reticuloendotheliosis as a pyrophosphatase.
Liver Neoplasms, Experimental
Subcellular distribution of inorganic pyrophosphatase activity in various normal and neoplastic cell types.
Lymphoma
Clinical significance and functional validation of inorganic pyrophosphatase in diffuse large B cell lymphoma in humans.
Lymphoma, B-Cell
Clinical significance and functional validation of inorganic pyrophosphatase in diffuse large B cell lymphoma in humans.
Lymphoma, Large B-Cell, Diffuse
Clinical significance and functional validation of inorganic pyrophosphatase in diffuse large B cell lymphoma in humans.
Magnesium Deficiency
Changes in the alkaline phosphatase (EC 3.1.3.1) and inorganic pyrophosphatase (EC 3.6.1.1) activities of rat tissues during magnesium deficiency. The importance of controlling feeding pattern.
Malaria
Acidification of the malaria parasite's digestive vacuole by a H+-ATPase and a H+-pyrophosphatase.
Malaria
Acidocalcisomes and a vacuolar H+-pyrophosphatase in malaria parasites.
Malaria
Piperaquine and Lumefantrine resistance in Plasmodium berghei ANKA associated with increased expression of Ca2+/H+ antiporter and glutathione associated enzymes.
Malaria
Vacuolar type H+ pumping pyrophosphatases of parasitic protozoa.
Manganese Poisoning
Dihydronicotinamide-adenine dinucleotide (NADH2) diaphorase, thiamine pyrophosphatase and acid phosphatase in the spinal cords of rabbits with chronic manganese poisoning.
Mitochondrial Diseases
Sudden Cardiac Death Due to Deficiency of the Mitochondrial Inorganic Pyrophosphatase PPA2.
Myocarditis
[Thiamine diphosphate level and metabolism in allergic myocarditis and treatment with peloid]
Neoplasm Metastasis
LHPP inhibits hepatocellular carcinoma cell growth and metastasis.
Neoplasm Metastasis
LHPP suppresses tumorigenesis of intrahepatic cholangiocarcinoma by inhibiting the TGF?/smad signaling pathway.
Neoplasm Metastasis
Proteomic profiling identifies the inorganic pyrophosphatase (PPA1) protein as a potential biomarker of metastasis in laryngeal squamous cell carcinoma.
Neoplasms
A Highly Sensitive Electrochemiluminescence Biosensor for Pyrophosphatase Detection Based on Click Chemistry-Triggered Hybridization Chain Reaction in Homogeneous Solution.
Neoplasms
Autotaxin (ATX), a potent tumor motogen, augments invasive and metastatic potential of ras-transformed cells.
Neoplasms
Autotaxin promotes motility via G protein-coupled phosphoinositide 3-kinase gamma in human melanoma cells.
Neoplasms
Clinical significance and functional validation of inorganic pyrophosphatase in diffuse large B cell lymphoma in humans.
Neoplasms
Discovery of the First Potent and Selective Inhibitors of Human dCTP Pyrophosphatase 1.
Neoplasms
Downregulation of LHPP Expression Associated with AFP Acts as a Good Prognostic Factor in Human Hepatocellular Carcinoma.
Neoplasms
Effect of colchicine on tumor growth and tumor pyrophosphatase.
Neoplasms
Galactosyltransferase activity in metastasizing and nonmetastasizing rat mammary carcinomas and its possible relationship with tumor cell surface antigen shedding.
Neoplasms
Identification of altered protein expression and post-translational modifications in primary colorectal cancer by using agarose two-dimensional gel electrophoresis.
Neoplasms
Identification of Critical Elements for Regulation of Inorganic Pyrophosphatase (PPA1) in MCF7 Breast Cancer Cells.
Neoplasms
Inorganic pyrophosphatase (PPA1) is a negative prognostic marker for human gastric cancer.
Neoplasms
LHPP exerts a tumor-inhibiting role in glioblastoma via the downregulation of Akt and Wnt/?-catenin signaling.
Neoplasms
LHPP impedes energy metabolism by inducing ubiquitin-mediated degradation of PKM2 in glioblastoma.
Neoplasms
LHPP inhibits cell growth and migration and triggers autophagy in papillary thyroid cancer by regulating the AKT/AMPK/mTOR signaling pathway.
Neoplasms
LHPP suppresses bladder cancer cell proliferation and growth via inactivating AKT/p65 signaling pathway.
Neoplasms
LHPP suppresses tumorigenesis of intrahepatic cholangiocarcinoma by inhibiting the TGF?/smad signaling pathway.
Neoplasms
Mechanisms of MTH1 inhibition-induced DNA strand breaks: The slippery slope from the oxidized nucleotide pool to genotoxic damage.
Neoplasms
MTH1 as a Chemotherapeutic Target: The Elephant in the Room.
Neoplasms
Nuclear translocation of ?-catenin during mesenchymal stem cells differentiation into hepatocytes is associated with a tumoral phenotype.
Neoplasms
Overexpression of autotaxin is associated with human renal cell carcinoma and bladder carcinoma and their progression.
Neoplasms
PPA1 promotes NSCLC progression via a JNK- and TP53-dependent manner.
Neoplasms
Prognostic impact of MutT homolog-1 expression on esophageal squamous cell carcinoma.
Neoplasms
Proteomic differences between hepatocellular carcinoma and non-tumorous liver tissue investigated by a combined 2D-DIGE and label-free quantitative proteomics study.
Neoplasms
Pyrophosphatase 1 expression is associated with future recurrence and overall survival in Chinese patients with intrahepatic cholangiocarcinoma.
Neoplasms
Pyrophosphate phosphohydrolase in C3HBA mammary tumors of mice.
Neoplasms
RNF186 regulates EFNB1 (ephrin B1)-EPHB2-induced autophagy in the colonic epithelial cells for the maintenance of intestinal homeostasis.
Neoplasms
Silencing PPA1 inhibits human epithelial ovarian cancer metastasis by suppressing the Wnt/?-catenin signaling pathway.
Neoplasms
Subcellular distribution of inorganic pyrophosphatase activity in various normal and neoplastic cell types.
Neoplasms
Targeted nanoparticle-mediated LHPP for melanoma treatment.
Neoplasms
The fine structural localisation of thiamine pyrophosphatase and adenosine triphosphatase in neural tumours induced by N-ethyl-N-nitrosourea in rats.
Neoplasms
Thiamine metabolism in the liver of mice with Ehrlich ascites carcinoma.
Neoplasms
Tumor suppressor LHPP regulates the proliferation of colorectal cancer cells via the PI3K/AKT pathway.
Neuralgia
CSF levels of apolipoprotein C1 and autotaxin found to associate with neuropathic pain and fibromyalgia.
Obesity
Association of genetic variation in ENPP1 with obesity-related phenotypes.
Osteomalacia
Sustained osteomalacia of long bones despite major improvement in other hypophosphatasia-related mineral deficits in tissue nonspecific alkaline phosphatase/nucleotide pyrophosphatase phosphodiesterase 1 double-deficient mice.
Ovarian Neoplasms
Identification of Critical Elements for Regulation of Inorganic Pyrophosphatase (PPA1) in MCF7 Breast Cancer Cells.
Ovarian Neoplasms
Uridine 5'-diphosphate-galactose:glycoprotein galactosyltransferase activity in the ovarian cancer patient.
Peptic Ulcer
[Ultrastructural localization of thiamine pyrophosphatase activity in the epitheliocytes of duodenal biopsies in peptic ulcer]
Pneumonia
Mycobacterium tuberculosis Rv3628 drives Th1-type T cell immunity via TLR2-mediated activation of dendritic cells and displays vaccine potential against the hyper-virulent Beijing K strain.
Relative Energy Deficiency in Sport
Encapsulation and differentiation of adipose-derived mesenchymal stem cells in a biomimetic purine cross-linked chitosan sponge.
Riboflavin Deficiency
Phenobarbital induced variations in hepatic ethyl-morphine n-demethylase and inorganic pyrophosphatase during riboflavin deficiency.
Rinderpest
The RNA triphosphatase domain of L protein of Rinderpest virus exhibits pyrophosphatase and tripolyphosphatase activities.
Sarcoma 37
Subcellular distribution of inorganic pyrophosphatase activity in various normal and neoplastic cell types.
Scabies
Identification of a novel PYP-1 gene in Sarcoptes scabiei and its potential as a serodiagnostic candidate by indirect-ELISA.
Scrapie
Ultrastructural cytochemical studies of cerebral microvasculature in scrapie infected mice.
Squamous Cell Carcinoma of Head and Neck
Proteomic profiling identifies the inorganic pyrophosphatase (PPA1) protein as a potential biomarker of metastasis in laryngeal squamous cell carcinoma.
Starvation
Immunoproteomic identification of antigenic candidate Campylobacter jejuni and human peripheral nerve proteins involved in Guillain-Barré syndrome.
Starvation
Studies on the activities of an acid phosphomonoesterase and an alkaline pyrophosphatase during the growth of Physarum polycephalum.
Starvation
The Arabidopsis thaliana phosphate starvation responsive gene AtPPsPase1 encodes a novel type of inorganic pyrophosphatase.
Starvation
Upregulation of vacuolar H(+)-translocating pyrophosphatase by phosphate starvation of Brassica napus (rapeseed) suspension cell cultures.
Starvation
[Study of inorganic pyrophosphatase activity in rabbit brain in the normal state and in starvation]
Stomach Neoplasms
Identification of Critical Elements for Regulation of Inorganic Pyrophosphatase (PPA1) in MCF7 Breast Cancer Cells.
Stomach Neoplasms
Inorganic pyrophosphatase (PPA1) is a negative prognostic marker for human gastric cancer.
Stomach Neoplasms
Pyrophosphatase overexpression is associated with cell migration, invasion, and poor prognosis in gastric cancer.
Teratocarcinoma
Cloning, chromosomal localization, and tissue expression of autotaxin from human teratocarcinoma cells.
Thyroid Diseases
Expression of new human inorganic pyrophosphatase in thyroid diseases: Its intimate association with hyperthyroidism.
Thyroid Nodule
Expression of new human inorganic pyrophosphatase in thyroid diseases: Its intimate association with hyperthyroidism.
Trypanosomiasis, African
Bisphosphonate inhibition of the exopolyphosphatase activity of the Trypanosoma brucei soluble vacuolar pyrophosphatase.
Tuberculosis
A novel non-radioactive primase-pyrophosphatase activity assay and its application to the discovery of inhibitors of Mycobacterium tuberculosis primase DnaG.
Tuberculosis
An unusual, His-dependent family I pyrophosphatase from Mycobacterium tuberculosis.
Tuberculosis
Analysis of stress- and host cell-induced expression of the Mycobacterium tuberculosis inorganic pyrophosphatase.
Tuberculosis
Backbone resonance assignment and dynamics of 110 kDa hexameric inorganic pyrophosphatase from Mycobacterium tuberculosis.
Tuberculosis
Discovery of allosteric and selective inhibitors of inorganic pyrophosphatase from Mycobacterium tuberculosis.
Tuberculosis
Effect of Structure Variations in the Inter-subunit Contact Zone on the Activity and Allosteric Regulation of Inorganic Pyrophosphatase from Mycobacterium tuberculosis.
Tuberculosis
Metal cofactors play a dual role in Mycobacterium tuberculosis inorganic pyrophosphatase.
Tuberculosis
Mycobacterium tuberculosis Rv3628 drives Th1-type T cell immunity via TLR2-mediated activation of dendritic cells and displays vaccine potential against the hyper-virulent Beijing K strain.
Tuberculosis
Structural and computational dissection of the catalytic mechanism of the inorganic pyrophosphatase from Mycobacterium tuberculosis.
Tuberculosis
Structural genomics of Mycobacterium tuberculosis: a preliminary report of progress at UCLA.
Tuberculosis
Structure of the Mycobacterium tuberculosis soluble inorganic pyrophosphatase Rv3628 at pH 7.0.
Urinary Calculi
Proceedings: Acid and alkaline urinary inorganic pyrophosphatase in the formation of calcium-containing urinary calculi.
Uterine Cervical Neoplasms
LHPP suppresses bladder cancer cell proliferation and growth via inactivating AKT/p65 signaling pathway.
Uterine Cervical Neoplasms
Tumor suppressor LHPP regulates the proliferation of colorectal cancer cells via the PI3K/AKT pathway.
Vascular Calcification
Extracellular pyrophosphate metabolism and calcification in vascular smooth muscle.
Vascular Calcification
Novel inhibitors of alkaline phosphatase suppress vascular smooth muscle cell calcification.
Virus Diseases
PPA2-associated sudden cardiac death: extending the clinical and allelic spectrum in 20 new families.
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3.6.1.1 inorganic diphosphatase
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The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). 
