Information on EC 3.6.1.1 - inorganic diphosphatase

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The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea

EC NUMBER
COMMENTARY hide
3.6.1.1
-
RECOMMENDED NAME
GeneOntology No.
inorganic diphosphatase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
diphosphate + H2O = 2 phosphate
show the reaction diagram
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phosphorous acid anhydride hydrolysis
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-
-
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
(aminomethyl)phosphonate degradation
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glyphosate degradation III
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non-pathway related
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Oxidative phosphorylation
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SYSTEMATIC NAME
IUBMB Comments
diphosphate phosphohydrolase
Specificity varies with the source and with the activating metal ion. The enzyme from some sources may be identical with EC 3.1.3.1 (alkaline phosphatase) or EC 3.1.3.9 (glucose-6-phosphatase). A form of this enzyme with a molecular mass of about 90 kDa is found in tonoplasts of plants and fungi, where it imports protons from the cytosol into the vacuolar lumen.
CAS REGISTRY NUMBER
COMMENTARY hide
9024-82-2
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
strain PCC 7120, gene ppa
SwissProt
Manually annotated by BRENDA team
hyperthermophilic bacterium
SwissProt
Manually annotated by BRENDA team
Aranda Christine
orchid
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
gene ppa
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-
Manually annotated by BRENDA team
Bristol strain N2, gene C47E12.4 or pyp-1
SwissProt
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
strain ATCC 8043
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-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
Helicobacter pylori ATCC 700392 / 26695
-
Uniprot
Manually annotated by BRENDA team
MdVHP1; genes MdVHP1 and MdVHP2
UniProt
Manually annotated by BRENDA team
MdVHP1; genes MdVHP1 and MdVHP2
UniProt
Manually annotated by BRENDA team
strain ATCC 35608
-
-
Manually annotated by BRENDA team
-
UniProt
Manually annotated by BRENDA team
mouse
-
-
Manually annotated by BRENDA team
-
UniProt
Manually annotated by BRENDA team
gene OVP1
O80384
UniProt
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
strain PCC 6903, gene ppa
SwissProt
Manually annotated by BRENDA team
-
UniProt
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
UniProt
Manually annotated by BRENDA team
strain PCC 6803, gene ppa
SwissProt
Manually annotated by BRENDA team
Thermus thermophilus HB8 / ATCC 27634 / DSM 579
-
Uniprot
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
evolution
malfunction
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knockdown of pyrophosphatase 1 decreases colony formation and viability of MCF-7 cells
metabolism
physiological function
additional information
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2-phosphorylethanolamine + H2O
ethanolamine + phosphate
show the reaction diagram
low activity
-
-
?
3'-AMP + H2O
adenosine + phosphate
show the reaction diagram
-
4% activity compared to diphosphate
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-
?
4-nitrophenyl phosphate + H2O
4-nitrophenol + phosphate
show the reaction diagram
ADP + H2O
?
show the reaction diagram
ADP + H2O
? + phosphate
show the reaction diagram
-
3-6% of the activity with diphosphate
-
-
?
ADP + H2O
AMP + phosphate
show the reaction diagram
-
5% activity compared to diphosphate
-
-
?
AMP + H2O
?
show the reaction diagram
-
3.6% relative activity compared to diphosphate
-
-
?
ATP + H2O
?
show the reaction diagram
ATP + H2O
? + phosphate
show the reaction diagram
-
3-6% of the activity with diphosphate
-
-
?
ATP + H2O
ADP + phosphate
show the reaction diagram
c-Jun N-terminale kinase + H2O
?
show the reaction diagram
-
-
-
-
?
CDP + H2O
?
show the reaction diagram
CTP + H2O
?
show the reaction diagram
cyclic tripolyphosphate + H2O
?
show the reaction diagram
D-fructose-6-phosphate + H2O
D-fructose + phosphate
show the reaction diagram
-
13% relative activity compared to diphosphate
-
-
?
D-glucose-1-phosphate + H2O
D-glucose + phosphate
show the reaction diagram
D-glucose-6-phosphate + H2O
D-glucose + phosphate
show the reaction diagram
low activity
-
-
?
dATP + H2O
dADP + phosphate
show the reaction diagram
7% activity compared to diphosphate
-
-
?
diphosphate + H2O
2 phosphate
show the reaction diagram
diphosphate + H2O
phosphate + phosphate
show the reaction diagram
diphosphates + H2O
?
show the reaction diagram
-
hydrolysis of organic diphosphates in the presence of Zn2+
-
-
?
GDP + H2O
?
show the reaction diagram
GMP + H2O
?
show the reaction diagram
-
18% relative activity compared to diphosphate
-
-
?
GTP + H2O
?
show the reaction diagram
guanosine 5'-tetraphosphate + H2O
?
show the reaction diagram
-
-
-
-
?
IDP + H2O
?
show the reaction diagram
-
-
-
?
imidodiphosphate + H2O
phosphate + NH3
show the reaction diagram
-
hydrolysis even in the absence of divalent cations
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ir
imidodiphosphate + H2O
phosphate + phosphoramidic acid
show the reaction diagram
active site and substrate binding structure determination and analysis, overview
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-
?
ITP + H2O
?
show the reaction diagram
-
-
-
?
ITP + H2O
? + phosphate
show the reaction diagram
-
10% of the activity with diphosphate
-
-
?
phosphoenolpyruvate + H2O
pyruvate + phosphate
show the reaction diagram
polyphosphate + H2O
?
show the reaction diagram
-
less than 1% activity compared to diphosphate
-
-
?
polyphosphate 75 + H2O
?
show the reaction diagram
-
-
-
-
?
tetrapolyphosphate + H2O
?
show the reaction diagram
thiamine diphosphate + H2O
?
show the reaction diagram
triphosphate + H2O
3 phosphate
show the reaction diagram
-
-
-
-
?
triphosphate + H2O
?
show the reaction diagram
triphosphate + H2O
? + phosphate
show the reaction diagram
-
3-6% of the activity with diphosphate
-
-
?
tripolyphosphate + H2O
?
show the reaction diagram
TTP + H2O
? + phosphate
show the reaction diagram
-
10% of the activity with diphosphate
-
-
?
UDP + H2O
?
show the reaction diagram
-
-
-
?
UDP-glucose + H2O
?
show the reaction diagram
-
-
-
?
UTP + H2O
?
show the reaction diagram
additional information
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
c-Jun N-terminale kinase + H2O
?
show the reaction diagram
-
-
-
-
?
diphosphate + H2O
2 phosphate
show the reaction diagram
additional information
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-
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Cd2+
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4 Cd2+ sites per subunit, enzyme activity lower compared to Mg2+
CdCl2
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20 mM, 155% stimulation
lanthanum
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results in a slow substrate binding to diphosphate
MgCl2
-
20 mM, 163% stimulation
NiCl2
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20 mM, 156% stimulation
additional information