Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
alpha-D-glucosamine 6-phosphate + H2O
D-fructose 6-phosphate + NH3
D-glucosamine 6-phosphate + H2O
D-fructose 6-phosphate + NH3
alpha-D-glucosamine 6-phosphate + H2O
D-fructose 6-phosphate + NH3
-
-
-
r
D-glucosamine 6-phosphate + H2O
D-fructose 6-phosphate + NH3
additional information
?
-
-
the activity of the enzyme in erythrocytes is low, indicating that hexosamine catabolism is not a major source of energy in the erythrocyte
-
-
?
alpha-D-glucosamine 6-phosphate + H2O
D-fructose 6-phosphate + NH3
-
-
-
r
alpha-D-glucosamine 6-phosphate + H2O
D-fructose 6-phosphate + NH3
in standard culture conditions keratinocyte GNPDAs mainly catalyze the reaction from GlcN6P back to Fru6P
-
-
r
D-glucosamine 6-phosphate + H2O
D-fructose 6-phosphate + NH3
-
-
-
?
D-glucosamine 6-phosphate + H2O
D-fructose 6-phosphate + NH3
-
-
r
D-glucosamine 6-phosphate + H2O
D-fructose 6-phosphate + NH3
-
-
-
?
D-glucosamine 6-phosphate + H2O
D-fructose 6-phosphate + NH3
-
-
-
r
D-glucosamine 6-phosphate + H2O
D-fructose 6-phosphate + NH3
-
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Asthma
Analyses of shared genetic factors between asthma and obesity in children.
Asthma
Obese individuals experience wheezing without asthma but not asthma without wheezing: a Mendelian randomisation study of 85?437 adults from the Copenhagen General Population Study.
Candidiasis
Attenuation of virulence and changes in morphology in Candida albicans by disruption of the N-acetylglucosamine catabolic pathway.
Carcinoma, Hepatocellular
Erratum: Glucosamine-6-Phosphate Isomerase 1 Promotes Tumor Progression and Indicates Poor Prognosis in Hepatocellular Carcinoma [Corrigendum].
Carcinoma, Hepatocellular
Glucosamine-6-Phosphate Isomerase 1 Promotes Tumor Progression and Indicates Poor Prognosis in Hepatocellular Carcinoma.
Colorectal Neoplasms
Identification of differential proteins in colorectal cancer cells treated with caffeic acid phenethyl ester.
Colorectal Neoplasms
Susceptibility variants for obesity and colorectal cancer risk: The multiethnic cohort and PAGE studies.
Cysts
Developmental gene regulation in Giardia lamblia: first evidence for an encystation-specific promoter and differential 5' mRNA processing.
Cysts
Proteomic Study of Entamoeba histolytica Trophozoites, Cysts, and Cyst-Like Structures.
Diabetes Mellitus, Type 2
A Perception on Genome-Wide Genetic Analysis of Metabolic Traits in Arab Populations.
Diabetes Mellitus, Type 2
Implication of genetic variants near NEGR1, SEC16B, TMEM18, ETV5/DGKG, GNPDA2, LIN7C/BDNF, MTCH2, BCDIN3D/FAIM2, SH2B1, FTO, MC4R, and KCTD15 with obesity and type 2 diabetes in 7705 Chinese.
Diabetes Mellitus, Type 2
Obesity-related genomic loci are associated with type 2 diabetes in a Han Chinese population.
Diabetes Mellitus, Type 2
Obesity-related loci in TMEM18, CDKAL1 and FAIM2 are associated with obesity and type 2 diabetes in Chinese Han patients.
Diabetes Mellitus, Type 2
Sexual Dimorphism of a Genetic Risk Score for Obesity and Related Traits among Chinese Patients with Type 2 Diabetes.
Fibrosarcoma
Association between obesity and polymorphisms in SEC16B, TMEM18, GNPDA2, BDNF, FAIM2 and MC4R in a Japanese population.
Insulin Resistance
Contribution of 24 obesity-associated genetic variants to insulin resistance, pancreatic beta-cell function and type 2 diabetes risk in the French population.
Neoplasm Metastasis
Glucosamine-6-Phosphate Isomerase 1 Promotes Tumor Progression and Indicates Poor Prognosis in Hepatocellular Carcinoma.
Neoplasms
Erratum: Glucosamine-6-Phosphate Isomerase 1 Promotes Tumor Progression and Indicates Poor Prognosis in Hepatocellular Carcinoma [Corrigendum].
Neoplasms
Glucosamine-6-Phosphate Isomerase 1 Promotes Tumor Progression and Indicates Poor Prognosis in Hepatocellular Carcinoma.
Neoplasms
Prognostic value of a novel glycolysis-related gene expression signature for gastrointestinal cancer in the Asian population.
Niemann-Pick Diseases
Association between obesity and polymorphisms in SEC16B, TMEM18, GNPDA2, BDNF, FAIM2 and MC4R in a Japanese population.
Obesity
Analysis of the contribution of FTO, NPC1, ENPP1, NEGR1, GNPDA2 and MC4R genes to obesity in Mexican children.
Obesity
Association between obesity and polymorphisms in SEC16B, TMEM18, GNPDA2, BDNF, FAIM2 and MC4R in a Japanese population.
Obesity
Association of genetic variants for susceptibility to obesity with type 2 diabetes in Japanese individuals.
Obesity
Association of variations in the FTO, SCG3 and MTMR9 genes with metabolic syndrome in a Japanese population.
Obesity
Associations of six single nucleotide polymorphisms in obesity-related genes with body mass index and risk of obesity in the Chinese children.
Obesity
Characterizing gene-gene interactions in a statistical epistasis network of twelve candidate genes for obesity.
Obesity
Effect of 15 BMI-Associated Polymorphisms, Reported for Europeans, across Ethnicities and Degrees of Amerindian Ancestry in Mexican Children.
Obesity
Environment and Gene Association With Obesity and Their Impact on Neurodegenerative and Neurodevelopmental Diseases.
Obesity
Exome sequencing in Thai patients with familial obesity.
Obesity
Genetic susceptibility, birth weight and obesity risk in young Chinese.
Obesity
GNPDA2 Gene Affects Adipogenesis and Alters the Transcriptome Profile of Human Adipose-Derived Mesenchymal Stem Cells.
Obesity
Identification, expression and variation of the GNPDA2 gene, and its association with body weight and fatness traits in chicken.
Obesity
Implication of genetic variants near NEGR1, SEC16B, TMEM18, ETV5/DGKG, GNPDA2, LIN7C/BDNF, MTCH2, BCDIN3D/FAIM2, SH2B1, FTO, MC4R, and KCTD15 with obesity and type 2 diabetes in 7705 Chinese.
Obesity
Obesity susceptibility loci in Qataris, a highly consanguineous Arabian population.
Obesity
Obesity-related genes are expressed in human Sertoli cells and modulated by energy homeostasis regulating hormones.
Obesity
Obesity-related genomic loci are associated with type 2 diabetes in a Han Chinese population.
Obesity
Obesity-related loci in TMEM18, CDKAL1 and FAIM2 are associated with obesity and type 2 diabetes in Chinese Han patients.
Obesity
Protective Association of Single Nucleotide Polymorphisms rs1861868-FTO and rs7975232-VDR and Obesity in Saudi Females.
Obesity
Replication and extension of genome-wide association study results for obesity in 4923 adults from northern Sweden.
Obesity
Replication of 13 obesity loci among Singaporean Chinese, Malay and Asian-Indian populations.
Obesity
Sexual Dimorphism of a Genetic Risk Score for Obesity and Related Traits among Chinese Patients with Type 2 Diabetes.
Obesity
Study of eight GWAS-identified common variants for association with obesity-related indices in Chinese children at puberty.
Obesity
The current review of adolescent obesity: the role of genetic factors.
Obesity
The Influence of Obesity-Related Single Nucleotide Polymorphisms on BMI Across the Life Course: The PAGE Study.
Obesity
The Relationships of Obesity-Related Genetic Variants With Metabolic Profiles and Response to Metformin in Clozapine-Treated Patients With Schizophrenia.
Obesity
Validation of BMI genetic risk score and DNA methylation in a Korean population.
Obesity
What model organisms and interactomics can reveal about the genetics of human obesity.
Pediatric Obesity
Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index.
Pediatric Obesity
Role of BMI-Associated Loci Identified in GWAS Meta-Analyses in the Context of Common Childhood Obesity in European Americans.
Synucleinopathies
Deployment of Label-Free Quantitative Olfactory Proteomics to Detect Cerebrospinal Fluid Biomarker Candidates in Synucleinopathies.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
0.27 - 16.5
D-glucosamine 6-phosphate
3.5 - 22.5
D-fructose 6-phosphate
0.041 - 2.37
D-glucosamine 6-phosphate
additional information
additional information
-
0.27
D-glucosamine 6-phosphate
recombinant wild-type isozyme GNPDA1, pH 8.0, 30°C, kinetic method 1, in absence of N-acetylglucosamine 6-phosphate
2
D-glucosamine 6-phosphate
recombinant isozyme GNPDA1 275 truncation mutant, pH 8.0, 30°C, kinetic method 1
16.5
D-glucosamine 6-phosphate
recombinant wild-type isozyme GNPDA1, pH 8.0, 30°C, kinetic method 1, in presence of saturating concentration of N-acetylglucosamine 6-phosphate
3.5
D-fructose 6-phosphate
-
pH 8.5, 37°C, in presence of N-acetylglucosamine 6-phosphate and Mn2+
22.5
D-fructose 6-phosphate
-
pH 8.5, 37°C, in absence of activators
0.041
D-glucosamine 6-phosphate
-
pH 9, 37°C
0.25
D-glucosamine 6-phosphate
-
pH 8.5, 37°C, in presence of N-acetylglucosamine 6-phosphate and Mn2+
2.37
D-glucosamine 6-phosphate
-
pH 8.5, 37°C, without activator
16
NH4+
-
pH 8.5, 37°C, in presence of N-acetylglucosamine 6-phosphate and Mn2+
25
NH4+
-
in absence of activators
additional information
additional information
allosteric enzyme, hGNPDA1 enzyme displays hyperbolic kinetics but very low-activity in the absence of GlcNAc6P, kinetic analysis and modelling of both reaction directions, detailed overview
-
additional information
additional information
allosteric enzyme, hGNPDA1 enzyme displays hyperbolic kinetics but very low-activity in the absence of GlcNAc6P, kinetic analysis and modelling of both reaction directions, detailed overview
-
additional information
additional information
-
allosteric enzyme, hGNPDA1 enzyme displays hyperbolic kinetics but very low-activity in the absence of GlcNAc6P, kinetic analysis and modelling of both reaction directions, detailed overview
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
malfunction
depletion of GFAT1 reduces the cellular pool of UDP-GlcNAc and hyaluronan synthesis, while simultaneous blocking of both isozymes GNPDA1 and GDPDA2 exerts opposite effects, indicating that in standard culture conditions keratinocyte GNPDAs mainly catalyze the reaction from GlcN6P back to Fru6P. When hexosamine biosynthesis is blocked by GFAT1 siRNA, the effect by GNPDAs is reversed, now catalyzing Fru6P towards GlcN6P, likely in an attempt to maintain UDPGlcNAc content. Silencing of these enzymes also changes the gene expression of related enzymes: GNPDA1 siRNA induces GFAT2 which is hardly measurable in these cells under standard culture conditions, GNPDA2 siRNA increases GFAT1, and GFAT1 siRNA increases the expression of hyaluronan synthase 2 (HAS2). Silencing of GFAT1 stimulates GNPDA1 and GDPDA2, and inhibites cell migration. The multiple delicate adjustments of these reactions demonstrate the importance of hexosamine biosynthesis in cellular homeostasis, known to be deranged in diseases like diabetes and cancer. GNPDA1 siRNA, while ineffective by itself, could largely prevent the influence of mannose on UDP-GlcNAc and hyaluronan synthesis, thus raising GNPDA1 as a specific candidate for the target of mannose. The finding that GNPDA1 siRNA does not counteract the mannose-induced depletion of cell surface hyaluronan suggests that in addition to GNPDA1 mannose may target cell surface receptor activity
metabolism
distinct contributions of glucosamine-6-phosphate (GlcN6P):glutamine-fructose-6-phosphate aminotransferases (GFAT1 and 2) and glucosamine-6-phosphate deaminases (GNPDA1 and 2)isozymes to the UDP-GlcNAc pool of cultured keratinocytes, and their consequences to the hyaluronan synthesis, one of the cellular processes most dependent on cytosolic UDP-GlcNAc supply, and to cell proliferation and migration, overview
physiological function
hGNPDA1 can be important for the maintenance of an adequate level of the pool of the UDP-GlcNAc6P, the N-acetylglucosylaminyl donor for many reactions in the cell
malfunction
depletion of GFAT1 reduces the cellular pool of UDP-GlcNAc and hyaluronan synthesis, while simultaneous blocking of both isozymes GNPDA1 and GDPDA2 exerts opposite effects, indicating that in standard culture conditions keratinocyte GNPDAs mainly catalyze the reaction from GlcN6P back to Fru6P. When hexosamine biosynthesis is blocked by GFAT1 siRNA, the effect by GNPDAs is reversed, now catalyzing Fru6P towards GlcN6P, likely in an attempt to maintain UDPGlcNAc content. Silencing of these enzymes also changes the gene expression of related enzymes:GNPDA1 siRNA induces GFAT2 which is hardly measurable in these cells under standard culture conditions, GNPDA2 siRNA increases GFAT1, and GFAT1 siRNA increases the expression of hyaluronan synthase 2 (HAS2). Silencing of GFAT1 stimulates GNPDA1 and GDPDA2, and inhibites cell migration. The multiple delicate adjustments of these reactions demonstrate the importance of hexosamine biosynthesis in cellular homeostasis, known to be deranged in diseases like diabetes and cancer
metabolism
distinct contributions of glucosamine-6-phosphate (GlcN6P):glutamine-fructose-6-phosphate aminotransferases (GFAT1 and 2) and glucosamine-6-phosphate deaminases (GNPDA1 and 2) isozymes to the UDP-GlcNAc pool of cultured keratinocytes, and their consequences to the hyaluronan synthesis, one of the cellular processes most dependent on cytosolic UDP-GlcNAc supply, and to cell proliferation and migration, overview
additional information
possible functional significance of the C-terminal extension of hGNPDA1 isozyme, which is not present in isoform 2
additional information
possible functional significance of the C-terminal extension of hGNPDA1 isozyme, which is not present in isoform 2
additional information
-
possible functional significance of the C-terminal extension of hGNPDA1 isozyme, which is not present in isoform 2
additional information
possible functional significance of the C-terminal extension of hGNPDA1 isozyme, which is not present in isoform 2
additional information
possible functional significance of the C-terminal extension of hGNPDA1 isozyme, which is not present in isoform 2
additional information
-
possible functional significance of the C-terminal extension of hGNPDA1 isozyme, which is not present in isoform 2
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
additional information
generation of mutants truncated at positions 260 and 275
additional information
generation of mutants truncated at positions 260 and 275
additional information
-
generation of mutants truncated at positions 260 and 275
additional information
siRNA silencing of isozymes GNPDA1 and GDPDA2 with or without simultanious silencing of glucosamine-6-phosphate (GlcN6P):glutamine-fructose-6-phosphate aminotransferases (GFAT1 and 2) isozymes, phenotypes, overview. Analysis of influences of the siRNAs against genes regulating hexosamine biosynthesis on mRNA levels of GFAT1, GNPDA1, and GNPDA2 by quantitative RT-PCR expression analysis. Cell proliferation and migration following GFAT and GNPDA depletion. GNPDA1 siRNA, while ineffective by itself, can largely prevent the influence of mannose on UDP-GlcNAc and hyaluronan synthesis, thus raising GNPDA1 as a specific candidate for the target of mannose. The finding that GNPDA1 siRNA does not counteract the mannose-induced depletion of cell surface hyaluronan suggests that in addition to GNPDA1 mannose may target cell surface receptor activity
additional information
siRNA silencing of isozymes GNPDA1 and GDPDA2 with or without simultanious silencing of glucosamine-6-phosphate (GlcN6P):glutamine-fructose-6-phosphate aminotransferases (GFAT1 and 2) isozymes, phenotypes, overview. Analysis of influences of the siRNAs against genes regulating hexosamine biosynthesis on mRNA levels of GFAT1, GNPDA1, and GNPDA2 by quantitative RT-PCR expression analysis. Cell proliferation and migration following GFAT and GNPDA depletion. GNPDA1 siRNA, while ineffective by itself, can largely prevent the influence of mannose on UDP-GlcNAc and hyaluronan synthesis, thus raising GNPDA1 as a specific candidate for the target of mannose. The finding that GNPDA1 siRNA does not counteract the mannose-induced depletion of cell surface hyaluronan suggests that in addition to GNPDA1 mannose may target cell surface receptor activity
additional information
-
siRNA silencing of isozymes GNPDA1 and GDPDA2 with or without simultanious silencing of glucosamine-6-phosphate (GlcN6P):glutamine-fructose-6-phosphate aminotransferases (GFAT1 and 2) isozymes, phenotypes, overview. Analysis of influences of the siRNAs against genes regulating hexosamine biosynthesis on mRNA levels of GFAT1, GNPDA1, and GNPDA2 by quantitative RT-PCR expression analysis. Cell proliferation and migration following GFAT and GNPDA depletion. GNPDA1 siRNA, while ineffective by itself, can largely prevent the influence of mannose on UDP-GlcNAc and hyaluronan synthesis, thus raising GNPDA1 as a specific candidate for the target of mannose. The finding that GNPDA1 siRNA does not counteract the mannose-induced depletion of cell surface hyaluronan suggests that in addition to GNPDA1 mannose may target cell surface receptor activity
additional information
siRNA silencing of isozymes GNPDA1 and GDPDA2 with or withour simultanious silencing of glucosamine-6-phosphate (GlcN6P): glutamine-fructose-6-phosphate aminotransferases (GFAT1 and 2) isozymes, phenotypes, overview. Analysis of influences of the siRNAs against genes regulating hexosamine biosynthesis on mRNA levels of GFAT1, GNPDA1, and GNPDA2 by quantitative RT-PCR expression analysis. Cell proliferation and migration following GFAT and GNPDA depletion
additional information
siRNA silencing of isozymes GNPDA1 and GDPDA2 with or withour simultanious silencing of glucosamine-6-phosphate (GlcN6P): glutamine-fructose-6-phosphate aminotransferases (GFAT1 and 2) isozymes, phenotypes, overview. Analysis of influences of the siRNAs against genes regulating hexosamine biosynthesis on mRNA levels of GFAT1, GNPDA1, and GNPDA2 by quantitative RT-PCR expression analysis. Cell proliferation and migration following GFAT and GNPDA depletion
additional information
-
siRNA silencing of isozymes GNPDA1 and GDPDA2 with or withour simultanious silencing of glucosamine-6-phosphate (GlcN6P): glutamine-fructose-6-phosphate aminotransferases (GFAT1 and 2) isozymes, phenotypes, overview. Analysis of influences of the siRNAs against genes regulating hexosamine biosynthesis on mRNA levels of GFAT1, GNPDA1, and GNPDA2 by quantitative RT-PCR expression analysis. Cell proliferation and migration following GFAT and GNPDA depletion
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Pattabiraman, T.N.; Bachhawat, B.K.
Purification of glucosamine 6-phosphate deaminase from human brain
Biochim. Biophys. Acta
54
273-283
1961
Homo sapiens
brenda
Weidanz, J.A.; Campbell, P.; DeLucas, L.J.; Jin, J.; Moore, D.; Roden, L.; Yu, H.; Heilmann, E.; Vezza, A.C.
Glucosamine 6-phosphate deaminase in normal human erythrocytes
Br. J. Haematol.
91
72-79
1995
Homo sapiens
brenda
Arreola, R.; Valderrama, B.; Morante, M.L.; Horjales, E.
Two mammalian glucosamine-6-phosphate deaminases: a structural and genetic study
FEBS Lett.
551
63-70
2003
Mus musculus, Homo sapiens (P46926), Homo sapiens
brenda
Alvarez-Anorve, L.I.; Alonzo, D.A.; Mora-Lugo, R.; Lara-Gonzalez, S.; Bustos-Jaimes, I.; Plumbridge, J.; Calcagno, M.L.
Allosteric kinetics of the isoform 1 of human glucosamine-6-phosphate deaminase
Biochim. Biophys. Acta
1814
1846-1853
2011
Homo sapiens (P46926), Homo sapiens (Q8TDQ7), Homo sapiens
brenda
Oikari, S.; Makkonen, K.; Deen, A.J.; Tyni, I.; Kaernae, R.; Tammi, R.H.; Tammi, M.I.
Hexosamine biosynthesis in keratinocytes roles of GFAT and GNPDA enzymes in the maintenance of UDP-GlcNAc content and hyaluronan synthesis
Glycobiology
26
710-722
2016
Homo sapiens (P46926), Homo sapiens (Q8TDQ7), Homo sapiens
brenda