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Information on EC 3.5.99.10 - 2-iminobutanoate/2-iminopropanoate deaminase

for references in articles please use BRENDA:EC3.5.99.10

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IUBMB Comments

This enzyme, which has been found in all species and tissues examined, catalyses the hydrolytic deamination of imine intermediates formed by several types of pyridoxal-5′-phosphate-dependent dehydratases, such as EC 4.3.1.19, threonine ammonia-lyase and EC 4.3.1.17, L-serine ammonia-lyase. The reactions, which can occur spontaneously, are accelerated to minimize the cellular damage that could be caused by these reactive intermediates.

The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea

Synonyms
reactive intermediate deaminase, enamine/imine deaminase, atrida, imine deaminase, st0811, 2-iminobutanoate/2-iminopropanoate deaminase, reactive intermediate deaminase a, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2-iminobutanoate + H2O = 2-oxobutanoate + NH3
show the reaction diagram
2-iminopropanoate + H2O = pyruvate + NH3
show the reaction diagram
PATHWAY SOURCE
PATHWAYS
MetaCyc
D-serine degradation, felinine and 3-methyl-3-sulfanylbutan-1-ol biosynthesis, glutathione-mediated detoxification I, glycine betaine degradation I, glycine betaine degradation III, hypoglycin biosynthesis, L-cysteine degradation II, L-isoleucine biosynthesis I (from threonine), L-methionine biosynthesis II, L-methionine degradation II, L-serine degradation, L-threonine degradation I, L-tryptophan degradation II (via pyruvate), purine nucleobases degradation II (anaerobic)
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