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IUBMB Comments Requires Fe2+. This enzyme forms part of the xanthine-degradation pathway in some bacteria. The product of the reaction, imidazol-4-one, can be converted non-enzymically into formiminoglycine. An enzyme has been identified in Clostridium cylindrosporum that can perform this hydrolysis reaction [2,3].
The expected taxonomic range for this enzyme is: Clostridium cylindrosporum
Synonyms
4-aminoimidazole hydrolase,
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4-aminoimidazole hydrolase
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4-aminoimidazole + H2O = imidazol-4-one + NH3
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amidine hydrolysis
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4-aminoimidazole aminohydrolase
Requires Fe2+. This enzyme forms part of the xanthine-degradation pathway in some bacteria. The product of the reaction, imidazol-4-one, can be converted non-enzymically into formiminoglycine. An enzyme has been identified in Clostridium cylindrosporum that can perform this hydrolysis reaction [2,3].
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4-aminoimidazole + H2O
formiminoglycine + NH3 + unidentified product
4-aminoimidazole + H2O
formiminoglycine + NH3 + unidentified product
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4-aminoimidazole + H2O
formiminoglycine + NH3 + unidentified product
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alkali-labile derivative of glycine, can be hydrolyzed to yield glycine
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4-aminoimidazole + H2O
formiminoglycine + NH3 + unidentified product
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4-aminoimidazole + H2O
formiminoglycine + NH3 + unidentified product
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alkali-labile derivative of glycine, can be hydrolyzed to yield glycine
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4-aminoimidazole + H2O
formiminoglycine + NH3 + unidentified product
4-aminoimidazole + H2O
formiminoglycine + NH3 + unidentified product
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alkali-labile derivative of glycine, can be hydrolyzed to yield glycine
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4-aminoimidazole + H2O
formiminoglycine + NH3 + unidentified product
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alkali-labile derivative of glycine, can be hydrolyzed to yield glycine
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Co2+
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restores activity of EDTA treated enzyme to 83% of the original activity
Fe2+
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divalent cation required for activity
Mn2+
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restores activity of EDTA treated enzyme to 60% of the original activity
Ni2+
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restores activity of EDTA treated enzyme to 23% of the original activity
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3-Amino-1,2,4-triazole
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4-Hydroxy-1,2,3-triazole
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less effective inhibitor
Co2+
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addition of 0.002 M reduces activity by 50% or more
histamine
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less effective inhibitor
Mg2+
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addition of 0.002 M reduces activity by 50% or more
Mn2+
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addition of 0.002 M reduces activity by 50% or more
Zn2+
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addition of 0.002 M reduces activity by 50% or more
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7
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in triethanolamine hydrochloride
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brenda
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brenda
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unstable in absence of reducing agents, completely inactive without cysteine, cysteine, sodium hydrosulfite, glutathione, sodium thioglycolate and ascorbic acid stabilizes enzyme activity
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Rabinowitz, J.C.; Pricer, W.E.
Purine fermentation by Clostridium cylindrosporum. V. Formiminoglycine
J. Biol. Chem.
222
537-554
1956
Clostridium cylindrosporum, Clostridium cylindrosporum HC1
brenda
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