Information on EC 3.5.4.46 - cAMP deaminase

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The expected taxonomic range for this enzyme is: Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130

EC NUMBER
COMMENTARY hide
3.5.4.46
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RECOMMENDED NAME
GeneOntology No.
cAMP deaminase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
3',5'-cyclic AMP + H2O = 3',5'-cyclic IMP + NH3
show the reaction diagram
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SYSTEMATIC NAME
IUBMB Comments
3',5'-cyclic AMP aminohydrolase
Requires Zn2+. The enzyme, isolated from the bacterium Leptospira interrogans, is specific for cAMP.
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
expression of CadD in Escherichia coli mimics the loss of adenylate cyclase in that it blocks growth on carbon sources that require the cAMP-CRP transcriptional activator complex for expression of the cognate genes. CadD expression represses expression of several cAMP-CRP dependent genes
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
3',5'-cyclic AMP + H2O
3',5'-cyclic IMP + NH3
show the reaction diagram
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?
additional information
?
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the enzyme specifically deaminates cAMP to cyclic-3',5'-inosine monophosphate and has no activity on adenosine, adenine, or 5'-adenosine monophosphate
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
kcat/KM VALUE [1/mMs-1]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE