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Information on EC 3.5.4.43 - hydroxydechloroatrazine ethylaminohydrolase

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IUBMB Comments
Contains Zn2+. This bacterial enzyme is involved in degradation of the herbicide atrazine. The enzyme has a broad substrate range, and requires a monohydroxylated s-triazine ring with a minimum of one primary or secondary amine substituent and either a chloride or amine leaving group. It catalyses both deamination and dechlorination reactions.
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The enzyme appears in viruses and cellular organisms
Synonyms
adenosine aminohydrolase 3, hydroxyatrazine ethylaminohydrolase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
hydroxyatrazine + H2O = N-isopropylammelide + ethylamine
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Involved in a pathway by which the herbicide atrazine, 2-chloro-4-(ethylamino)-6-(isopropylamino)-1,3,5-triazine, is degraded in bacteria via N-isopropylammelide, 2,4-dihydroxy-6-(isopropylamino)-1,3,5-triazine
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