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Information on EC 3.5.4.43 - hydroxydechloroatrazine ethylaminohydrolase

for references in articles please use BRENDA:EC3.5.4.43

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IUBMB Comments

Contains Zn2+. This bacterial enzyme is involved indegradation of the herbicide atrazine. The enzyme has a broad substrate range, and requires a monohydroxylated s-triazine ring with a minimum of one primary or secondary amine substituent and either a chloride or amine leaving group. It catalyses both deamination and dechlorination reactions.

The expected taxonomic range for this enzyme is: Bacteria, Archaea, Eukaryota

Synonyms
adenosine aminohydrolase 3, hydroxyatrazine ethylaminohydrolase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
hydroxyatrazine + H2O = N-isopropylammelide + ethylamine
show the reaction diagram
Involved in a pathway by which the herbicide atrazine, 2-chloro-4-(ethylamino)-6-(isopropylamino)-1,3,5-triazine, is degraded in bacteria via N-isopropylammelide, 2,4-dihydroxy-6-(isopropylamino)-1,3,5-triazine
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