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Information on EC 3.5.4.39 - GTP cyclohydrolase IV

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IUBMB Comments
Requires Fe2+. A zinc protein. The enzyme is involved in methanopterin biosynthesis in methanogenic archaea. cf. GTP cyclohydrolase I (EC 3.5.4.16), GTP cyclohydrolase II (EC 3.5.4.25) and GTP cyclohydrolase IIa (EC 3.5.4.29).
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The expected taxonomic range for this enzyme is: Archaea, Bacteria
Synonyms
GTP cyclohydrolase MptA, MptA, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
GTP + H2O = 7,8-dihydroneopterin 2',3'-cyclic phosphate + formate + diphosphate
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